`
`Sequence Listing was accepted.
`
`
`
`
`If you need help call the Patent ?1ectronic Qusiness Center at
`
`217—9197 (toll free).
`
`(866)
`
`Reviewer: Anjum, Durreshwar
`
`sec=28; ms=364;
`[year=2018; month=7; day=12; hr=8; min=12;
`Timestamp:
`
`
`]
`
`

`

`Validated By CRFValidator v 1,0,5
`
`Application No:
`
`16068830
`
`Version No:
`
`1.0
`
`Input Set:
`
`Output Set:
`
`Started:
`
`2018-07-09 16:24:56.404
`
`Finished:
`
`2018-07-09 16:24:56.880
`
`0 min(s)
`
`0 sec(s)
`
`476 ms
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`fld
`
`fld
`
`fld
`
`fld
`
`fld
`
`0 hr(s)
`12
`
`0 4
`
`5
`
`45
`
`flown
`
`50L
`
`flown
`
`50L
`
`Elapsed:
`
`Total Warnings:
`
`Total Errors:
`
`No. of SquDs Defined:
`
`Actual SquD Count:
`
`Error Description
`II
`
`
`II
`
`Ar
`
`II
`
`II
`
`'C'a
`
`II
`
`'C'a
`
`II
`
`'C'a
`
`II
`
`'C'a
`
`II
`
`II
`
`II
`
`II
`
`II
`
`Ar
`
`Ar
`
`Ar
`
`Ar
`
`Ar
`
`or on
`
`flown
`
`50L
`
`or on
`
`flown
`
`50L
`
`or on
`
`flown
`
`50L
`
`or on
`
`flown
`
`50L
`
`Error code
`
`W
`
`W
`
`W
`
`W
`
`W
`
`2u3
`
`2u3
`
`2H3
`
`2u3
`
`2u3
`
`
`
`2H3
`
`2u3
`
`2u3
`
`2H3
`
`2u3
`
`2u3
`
`2H3
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`II
`
`II
`
`II
`
`II
`
`II
`
`II
`
`Ar
`
`Ar
`
`Ar
`
`Ar
`
`Ar
`
`Ar
`
`II
`
`'C'a
`
`II
`
`'C'a
`
`II
`
`'C'a
`
`II
`
`'C'a
`
`II
`
`
`
`
`
`II
`
`
`
`
`or on
`
`or on
`
`or on
`
`or on
`
`
`
`
`
`flown
`
`flown
`
`flown
`
`flown
`
`flown
`
`flown
`
`
`
`
`
`50L
`
`50L
`
`50L
`
`50L
`
`50L
`
`50L
`
`
`
`fld
`
`fld
`
`fld
`
`fld
`
`fld
`
`fld
`
`fld
`
`
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`
`<7n3>
`?Q
`
`
`
`
`
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`
`<7n3>
`
`?Q
`
`?Q
`
`
`
`(41)
`
`(42)
`
`(43)
`
`(44)
`
`(45)
`
`

`

`
`
`
`S~QUPNC~ LISLING
`
`<"10> Replimune Limited
`
`<i20>
`
`<"30>
`
`
`
`<NGIN4<RED VIRUS
`
`406716WO
`
`
`
`JS 16/068,830
`< 40>
`<"4l> 2018—07—09
`
`
`
`<"50> GB1600380.8
`<"51>
`2016—01—08
`
`<"50> GBl600381.6
`<"51>
`2016—01—08
`
`<"50> GB1600382.4
`<"51>
`2016—01—08
`
`<"60>
`
`45
`
`<i70> PatentIn version 3.5
`
`l
`<210>
`426
`<211>
`DNA
`<212>
`<213> Mus musculus
`
`<400>
`
`l
`
`atgtggctgc agaatttact tttcctgggc attgtggtct acagcctctc agcacccacc
`
`cgctcaccca tcactgtcac ccggccttgg aagcatgtag aggccatcaa agaagccctg
`
`aacctcctgg atgacatgcc tgtcacattg aatgaagagg tagaagtcgt
`
`thtaacgag
`
`ttctccttca agaagctaac atgtgtgcag acccgcctga agatattcga gcagggtcta
`
`cggggcaatt tcaccaaact caagggcgcc ttgaacatga cagccagcta ctaccagaca
`
`tactgccccc caactccgga aacggactgt gaaacacaag ttaccaccta tgcggatttc
`
`atagacagcc ttaaaacctt tctgactgat atcccctttg aatgcaaaaa accagtccaa
`
`aaatga
`
`2
`<210>
`426
`<211>
`DNA
`<212>
`<213> Mus musculus
`
`<400>
`
`2
`
`atgtggctcc agaacctcct cttcctcggt atcgtcgtgt attcactctc cgcacctact
`
`cgctcaccta tcactgtcac cagaccctgg aagcacgtgg aggccatcaa ggaggctctg
`
`60
`
`120
`
`180
`
`240
`
`300
`
`360
`
`420
`
`426
`
`60
`
`120
`
`

`

`aacctgctgg
`
`acgatatgcc
`
`agtgaccctg
`
`aacgaggagg
`
`tggaggtggt
`
`gagcaacgag
`
`ttctccttta
`
`agaagctgac
`
`ctgcgtgcag
`
`acaaggctga
`
`agatcttcga
`
`gcagggcctg
`
`agaggaaact
`
`ttaccaagct
`
`gaagggcgcc
`
`ctgaacatga
`
`ccgcttctta
`
`ctaccagaca
`
`tactgccccc
`
`ctacccccga
`
`gacagactgt
`
`gagacacagg
`
`tgaccacata
`
`cgccgacttc
`
`attgatagcc
`
`tgaaaacatt
`
`cctgaccgac
`
`attccatttg
`
`agtgtaagaa
`
`gcccgtccag
`
`aagtaa
`
`<210>
`<211>
`<212>
`<213>
`
`3
`435
`DNA
`
`Homo sapiens
`
`<400>
`
`3
`
`atgtggctgc
`
`agagcctgct
`
`gotcttgggo
`
`actgtggoct
`
`goagcatctc
`
`tgcaoccgcc
`
`cgctcgccca
`
`gccccagcac
`
`gcagccctgg
`
`gagcatgtga
`
`atgccatcca
`
`ggaggcccgg
`
`cgtctcctga
`
`acctgagtag
`
`agacactgct
`
`gctgagatga
`
`atgaaacagt
`
`agaagtcatc
`
`tcagaaatgt
`
`ttgacctcca
`
`ggagccgaco
`
`tgcctacaga
`
`cccgcctgga
`
`gctgtacaag
`
`cagggcctgc
`
`ggggcagcct
`
`caccaagctc
`
`aagggcccct
`
`tgaccatgat
`
`ggccagccac
`
`180
`
`240
`
`300
`
`420
`
`426
`
`60
`
`120
`
`180
`
`240
`
`tacaagcagc
`
`actgccctcc
`
`aaccccggaa
`
`acttcctgtg
`
`caacccagat
`
`tatcaccttt
`
`gaaagtttca
`
`aagagaacct
`
`gaaggacttt
`
`ctgcttgtca
`
`tcccctttga
`
`ctgctgggag
`
`ccagtccagg
`
`agtga
`
`<210>
`<211>
`<212>
`<213>
`
`4
`435
`DNA
`
`Homo sapiens
`
`<400>
`
`4
`
`atgtggctgc
`
`agtccctgct
`
`gctgctgggc
`
`accgtcgcct
`
`gttctatttc
`
`cgcacccgca
`
`aggtcaccaa
`
`gtccatctac
`
`tcagccttgg
`
`gagcacgtga
`
`acgcaatcca
`
`ggaggcacgg
`
`ngctgctga
`
`aoctgagccg
`
`ggacaccgco
`
`gccgagatga
`
`aogagacagt
`
`ggaagtgatc
`
`agcgagatgt
`
`tcgatctgca
`
`ggagcccacc
`
`tgcctgcaga
`
`caaggctgga
`
`gctgtacaag
`
`cagggcctgc
`
`gcggctctct
`
`gaccaagctg
`
`aagggcccac
`
`tgacaatgat
`
`ggccagccac
`
`tataagcagc
`
`actgcccccc
`
`tacccccgag
`
`acaagctgtg
`
`ccacccagat
`
`catcacattc
`
`gagtccttta
`
`aggagaacct
`
`gaaggatttt
`
`ctgctggtca
`
`ttccatttga
`
`ttgttgggag
`
`cccgtccagg
`
`agtaa
`
`360
`
`420
`
`435
`
`60
`
`120
`
`180
`
`240
`
`300
`
`360
`
`420
`
`435
`
`

`

`5 1
`
`41
`PRT
`
`Mus musculus
`
`<210>
`<21l>
`<212>
`<213>
`
`<400>
`
`Met
`
`Trp
`
`Leu Gln Asn
`
`Leu
`
`Leu
`
`Phe
`
`Ile
`
`Val
`
`Val
`
`Leu
`
`Leu Gly
`10
`
`Ser
`
`Ala
`
`Pro Thr Arg
`20
`
`Ser
`
`Pro
`
`Ile
`
`Thr Val
`25
`
`Thr
`
`Arg
`
`Pro
`
`Lys
`
`His
`
`Trp
`30
`
`Val
`
`Glu
`
`Ala Ile Lys
`35
`
`Glu
`
`Ala
`
`Leu
`40
`
`Asn Leu
`
`Leu
`
`Met
`
`Pro
`
`Val
`
`45
`
`Thr
`
`Leu
`50
`
`Asn Glu Glu
`
`Val
`
`Val
`
`Val Ser
`
`Asn
`
`Glu
`55
`
`Phe
`
`Phe
`
`Glu
`60
`
`Leu
`
`Phe
`
`Glu
`
`Gln
`
`Leu
`
`Lys
`65
`
`Thr Cys Val
`
`Gln
`7O
`
`Thr
`
`Arg
`
`Leu Lys
`
`Ile
`75
`
`Gly
`
`80
`
`Arg
`
`Gly
`
`Asn Phe Thr
`85
`
`Leu
`
`Gly Ala
`90
`
`Leu
`
`Met
`
`Thr
`
`Ser
`
`Ala
`95
`
`Gln Thr Tyr
`100
`
`Pro
`
`Pro
`
`Thr Pro
`105
`
`Glu
`
`Thr
`
`Asp
`
`Glu
`
`Thr
`
`Cys
`110
`
`Gln
`
`Val
`
`Thr Thr Tyr
`115
`
`Ala
`
`Phe
`120
`
`Ile Asp
`
`Ser
`
`Leu
`
`Lys
`125
`
`Thr
`
`Phe
`
`Leu
`
`Thr
`
`Asp
`130
`
`Ile Pro Phe
`
`Glu
`
`Cys
`135
`
`Lys
`
`Lys Pro
`
`Val
`
`Gln
`140
`
`6 1
`
`44
`PRT
`
`Homo sapiens
`
`<210>
`<211>
`<212>
`<213>
`
`<400>
`
`Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
`1
`5
`10
`15
`
`Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His
`
`

`

`20
`
`25
`
`3O
`
`Val
`
`Asn
`
`Ala
`35
`
`Ile Gln
`
`Glu
`
`Ala Arg
`40
`
`Arg Leu Leu
`
`Asn
`
`Leu Ser
`45
`
`Arg Asp
`
`Thr Ala
`50
`
`Ala
`
`Glu Met
`
`Asn
`
`Thr
`
`Val Glu Val
`
`Glu
`55
`
`Ile
`6O
`
`Ser Glu
`
`Met Phe
`
`Leu Gln
`
`Glu Pro
`
`Thr
`70
`
`Leu
`
`Gln Thr Arg
`75
`
`Leu Glu Leu
`
`Lys
`80
`
`Gln Gly Leu
`
`Arg
`
`Leu Thr
`
`85
`
`Leu
`90
`
`Gly Pro Leu
`
`Met
`
`Thr
`95
`
`Met Ala Ser
`
`His
`100
`
`Gln His
`
`Cys Pro Pro
`105
`
`Thr
`
`Pro
`
`Thr Ser
`
`Glu
`110
`
`Ala "hr
`
`Gln Ile
`
`Ile
`
`Thr Phe
`120
`
`Glu Ser Phe
`
`Glu
`125
`
`Leu
`
`"15
`
`.4611
`
`Phe
`130
`
`Leu Val
`
`Ile
`
`Pro Phe
`135
`
`Trp
`
`Glu
`140
`
`Pro Val
`
`Gln Glu
`
`<210>
`<211>
`<212>
`<213>
`
`7
`2010
`DNA
`Gibbon leukemia virus
`
`<400>
`
`7
`
`acctcaaacc
`
`atggtattgc
`
`tgcctgggtc
`
`catgcttctc
`
`tgcaccacct
`
`toggcaccag
`
`atgagtcctg
`
`ggagctggaa
`
`aagactgatc
`
`atcctcttaa
`
`gctgcgtatt
`
`ngngngC
`
`gggacgagtc
`
`tgcaaaataa
`
`gaacccccac
`
`cagcccatga
`
`ccctcacttg
`
`gcaggtactg
`
`tcccaaactg
`
`gagacgttgt
`
`ctgggataca
`
`aaggcagtcc
`
`agcccccttg
`
`gacttggtgg
`
`cccacactta
`
`aacctgatgt
`
`atgtgccttg
`
`goggctagtc
`
`ttgagtcctg
`
`ggatatcccg
`
`ggaaccgatg
`
`tctcgtcctc
`
`taaacgagtc
`
`agacctccgg
`
`actcagacta
`
`tactgccgct
`
`tataagcaaa
`
`tcacctgggg
`
`agccataggg
`
`tgcagctacc
`
`ctcgggctag
`
`gactagaatg
`
`gcaagctcta
`
`ccttctacgt
`
`atgtccccgg
`
`gatggccgga
`
`ccctttcaga
`
`agctagaagg
`
`tgcggggggc
`
`tagaatccct
`
`atactgtaaa
`
`gaatgggatt
`
`gtgagaccac
`
`ggggaccggt
`
`tattggctat
`
`ctaaatcctc
`
`aaaagacctc
`
`ataactgtaa
`
`aatgggacca
`
`aaatagcgaa
`
`60
`
`120
`
`180
`
`240
`
`360
`
`420
`
`480
`
`540
`
`600
`
`

`

`tggactcaaa
`
`aatttcaaca
`
`gtgtcaccag
`
`accggctggt
`
`gtaaccccct
`
`taaaatagat
`
`ttcacagaca
`
`aaggaaaatt
`
`atccaaggac
`
`tggataacgg
`
`gaaaaacctg
`
`gggattaaga
`
`ttctatgtgt
`
`ctggacatcc
`
`aggcgtacag
`
`ttcaccattc
`
`gcttaaaaat
`
`caccaacatg
`
`ccagctgtgg
`
`cagtaggtcc
`
`tgacctcgtc
`
`cttgtggaac
`
`aaggacctcc
`
`tagaacgtcc
`
`ctcgctctcc
`
`cacctcctct
`
`tcccccaagg
`
`gaagcgccac
`
`cgccatctct
`
`ccccgactct
`
`aactccacag
`
`ccctggcgac
`
`tagtgcacaa
`
`actcccacgg
`
`tgagaaaaac
`
`aattgttacc
`
`ctaaacactc
`
`cgcctcccac
`
`cacaggcgac
`
`agactttttg
`
`atcttgtgca
`
`gggggccttc
`
`ctaaccttaa
`
`atgctaccaa
`
`cccaggggcc
`
`actgagtctt
`
`gctggctttg
`
`tttggccatg
`
`ggcccccctt
`
`attatgaagc
`
`aatagcctca
`
`tcaggagagg
`
`tcgcctactc
`
`caccgacctt
`
`gaccggtgcc
`
`gctgggggac
`
`ccaaggaaag
`
`ctcaccctca
`
`ctgaggtctc
`
`aggacacggg
`
`660
`
`720
`
`780
`
`840
`
`900
`
`960
`
`"020
`
`"080
`
`”140
`
`"200
`
`ttgtgcatag
`
`gaaaggtgcc
`
`ctttacccat
`
`cagcatctct
`
`gcaatcagac
`
`cctatccatc
`
`"260
`
`aattcctccg
`
`gagaccatca
`
`gtatctgctc
`
`acctccaacc
`
`atagctggtg
`
`ggcttgcagc
`
`ctccacctca
`
`”320
`
`"380
`
`actggcctca
`
`ccccttgcct
`
`gtttttaatc
`
`agactagaga
`
`tttctgtatc
`
`caggtccagc
`
`tgattcctcg
`
`catctattac
`
`tatcctgaag
`
`aagttttgtt
`
`acaggcctat
`
`gacaattctc
`
`accccaggac
`
`taaaagagag
`
`gctgtctcac
`
`ttaccctagc
`
`tgttttactg
`
`gggttgggaa
`
`tcacggcggg
`
`aataggtact
`
`ggttcaactg
`
`ccttaattaa
`
`aggacctata
`
`gacctccagc
`
`aaggcctgac
`
`aagcctccag
`
`atcgccatag
`
`atgctgacct
`
`ccgggccctc
`
`caagactcag
`
`tcagcaagtt
`
`agaggactca
`
`Ctgacttccc
`
`tgtccgaggt
`
`agtgctccaa
`
`aataggagag
`
`gccttgactt
`
`gctgtttcta
`
`aaagaaggtg
`
`gcctctgtgc
`
`ggccctaaag
`
`gaagagtgct
`
`gtttttacat
`
`agaccactca
`
`ggtgcagtac
`
`gggactccat
`
`gaaaaaactc
`
`aaagaaaaac
`
`tggataaaag
`
`acagttagag
`
`cgccagaaaa
`
`gccaaaactg
`
`gtatgaagga
`
`tggttcaata
`
`actccccttg
`
`gttcactacc
`
`ctgctatcaa
`
`ccatcgctgg
`
`gcccctatta
`
`
`
`"740
`
`"800
`
`"860
`
`"920
`
`"440
`
`”500
`
`"560
`
`"620
`
`”680
`
`ctcctccttc
`
`tgttgctcat
`
`cctcgggcca
`
`tgcatcatca
`
`ataagttagt
`
`tcaattcatc
`
`"980
`
`aatgatagga
`
`taagtgcagt
`
`taaaatttaa
`
`2010
`
`<2lO>
`<211>
`<212>
`<2l3>
`
`8
`2013
`DNA
`Gibbon leukemia virus
`
`<400>
`
`8
`
`accatggtcc tgctgcctgg gtctatgctg ctgacttcta acctgcacca cctgcgacac
`
`60
`
`

`

`cagatgtctc
`
`ccggctcatg
`
`gaaacggctg
`
`atcatcctgc
`
`tgagctgcgt
`
`gttcggagga
`
`ggaggcacct
`
`ccctgcagaa
`
`caagaatcct
`
`caccagccaa
`
`tgaccctgac
`
`atggcaggtg
`
`ctgtcccaga
`
`caggcgacgt
`
`ggtgtgggat
`
`accaaggcag
`
`tgcagccacc
`
`ttggacatgg
`
`tggcccaccc
`
`tgaagcctga
`
`cgtgtgcgcc
`
`ctggccgcct
`
`ccctggagtc
`
`ttgggacatc
`
`cccggcacag
`
`acgtgagcag
`
`cagcaagagg
`
`gtgagaccac
`
`ccgactctga
`
`ttatacagcc
`
`gcctacaagc
`
`agatcacctg
`
`gggcgccatc
`
`ggctgtagct
`
`atcctcgggc
`
`ccgcacaagg
`
`atggccagct
`
`ccacctttta
`
`cgtgtgccca
`
`cgcgacggaa
`
`ggaccctgtc
`
`tgaggcaagg
`
`attgtgagac
`
`cacaggcaca
`
`120
`
`180
`
`240
`
`360
`
`420
`
`480
`
`540
`
`agatgtggcg
`
`gcctggagag
`
`cctgtattgc
`
`aaggagtggg
`
`ggctactggc
`
`tgtctaagtc
`
`tagcaaggac
`
`Ctgatcaccg
`
`tgaagtggga
`
`tcagaacagc
`
`gagtggacac
`
`agaagttcca
`
`gcagtgccac
`
`cagaccggct
`
`ggtgtaatcc
`
`cctgaagatc
`
`gactttacag
`
`ataagggcaa
`
`gctgtccaag
`
`gactggatca
`
`ccggcaagac
`
`atggggcctg
`
`agattctacg
`
`tgtctggcca
`
`ccctggcgtg
`
`cagtttacaa
`
`tccggctgaa
`
`gatcaccaac
`
`atgccagcag
`
`tggcagtggg
`
`accagacctg
`
`gtgctggtgg
`
`agcagggacc
`
`tccacgcacc
`
`tccctggccc
`
`tgccccctcc
`
`actgccccct
`
`agggaggccc
`
`caccccctag
`
`cctgcccgat
`
`cagaccccta
`
`cagtgcgcaa
`
`gaccatcgtg
`
`600
`
`660
`
`720
`
`780
`
`840
`
`900
`
`960
`
`tctaacagca
`
`cagccctggc
`
`cacctccgcc
`
`acactgaata
`
`ccccaccccc
`
`taccacaggc
`
`gacaggctgt
`
`tcgatctggt
`
`gcagggcgcc
`
`tttctgacac
`
`tgaacgccac
`
`caatcctggc
`
`gcaaccgaga
`
`gctgctggct
`
`gtgcctggct
`
`atgggcccac
`
`CCtaCtatga
`
`ggcaatcgcc
`
`tcctctggag
`
`aggtggcata
`
`ttccacagac
`
`ctggatagat
`
`gcagatgggg
`
`cacccagggc
`
`aagctgaccc
`
`tgacagaggt
`
`gtctggccac
`
`ggcctgtgca
`
`tcggcaaggt
`
`gccattcaca
`
`caccagcacc
`
`tgtgcaacca
`
`gaccctgagc
`
`atcaatagct
`
`ccggcgacca
`
`ccagtacctg
`
`ctgccaagca
`
`accactcctg
`
`gtgggcatgc
`
`tgaccccatg
`
`tctgagcacc
`
`agcgtgttca
`
`accagaccag
`
`agacttttgt
`
`"020
`
`"080
`
`”140
`
`"200
`
`"260
`
`"320
`
`"380
`
`
`
`"440
`
`”500
`
`"620
`
`"680
`
`tccacaggac
`
`atccaggtgc
`
`agctgatccc
`
`tcggatctac
`
`tattacccag
`
`aggaggtgct
`
`gctgcaggcc
`
`tatgataatt
`
`cccacccaag
`
`aacaaagagg
`
`gaggccqtgt
`
`thtgaccct
`
`ggccgtgctg
`
`ctgggactgg
`
`gaatcacagc
`
`aggaatcggc
`
`acaggcagca
`
`ccgccctgat
`
`caagggacca
`
`atcgacctgc
`
`agcagggact
`
`gacctccctg
`
`cagatcgcca
`
`tcgacgccga
`
`tctgagagcc
`
`ctgcaggaca
`
`gcgtgtccaa
`
`gctggaggat
`
`tctctgacct
`
`ctctgagcga
`
`ggtggtgctg
`
`cagaacagga
`
`ggggcctgga
`
`cctgctgttc
`
`ctgaaggagg
`
`gaggactgtg
`
`cgccgccctg
`
`aaggaggagt
`
`gctgttttta
`
`tatcgaccac
`
`tctggcgccg
`
`tgcgggatag
`
`catgaagaag
`
`"800
`
`"740
`
`

`

`ctgaaggaga
`
`agctggataa
`
`gcgccagctg
`
`gagaggcaga agagccagaa ttggtacgag
`
`ggctggttca
`
`acaattcccc
`
`ctggtttacc
`
`acactgctgt ctaccatcgc aggacctctg
`
`ttattactgc
`
`tgctgctgct
`
`gatcctgggc
`
`ccatgtatca tcaacaagct ggtgcagttt
`
`atcaacgacc
`
`gaatctccgc
`
`agtgaaaatc
`
`taa
`
`1860
`
`1920
`
`1980
`
`2013
`
`<210>
`<211>
`<212>
`<213>
`
`9
`669
`PRT
`Gibbon leukemia virus
`
`<400>
`
`9
`
`Met Val Leu
`1
`
`Leu Pro
`
`Ser Met
`
`Leu
`
`.4911
`
`Thr Ser
`
`Asn
`
`Leu
`
`His
`
`His
`15
`
` "rp
`
`Leu Arg His
`
`Glu
`20
`
`Met Ser
`
`Pro Gly
`
`Lys Arg
`
`Leu
`
`Ile
`
`Leu
`
`Ile
`30
`
`Leu Ser Cys
`35
`
`Val Phe
`
`Gly
`40
`
`Thr
`
`Ser Leu
`
`Gln
`45
`
`Asn
`
`Asn
`
`Pro
`
`His Gln
`50
`
`Pro Met
`
`Thr
`
`Leu Thr
`55
`
`Trp
`
`Gln
`
`Val Leu
`60
`
`Ser
`
`Gln Thr
`
`Ala
`
`Val
`
`Gln
`
`Val Val
`
`Trp Asp
`
`Thr
`70
`
`65
`
`Pro Pro
`75
`
`Trp
`
`Thr Trp
`
`Trp
`80
`
`Pro Thr Leu
`
`Pro
`
`85
`
`Val
`
`Ala
`
`Leu
`
`Ala Ala
`
`Ser
`
`Leu
`
`90
`
`Ser
`
`Glu
`95
`
`Trp
`
`Ile
`
`Pro
`100
`
`Thr
`
`Val
`
`Ser
`105
`
`Ser
`
`Ser Lys
`
`Arg
`
`Arg
`
`Pro
`
`Val
`110
`
`Pro
`
`Ser
`115
`
`Asp
`
`Thr
`
`Ala Ala
`120
`
`Lys
`
`Gln Ile
`
`Trp Gly
`
`Ala
`
`Thr
`125
`
`Ile Gly
`130
`
`Ser
`
`Pro
`
`Arg Ala
`135
`
`Arg
`
`Thr
`
`Arg Met
`140
`
`Ala
`
`Ser
`
`Ser
`
`Thr
`
`Phe
`145
`
`Val
`
`Pro
`
`Arg
`150
`
`Gly
`
`Arg
`
`Thr
`
`Leu Ser
`155
`
`Glu
`
`Ala Arg
`
`Arg
`160
`
`

`

`Gly
`
`Gly
`
`Leu
`
`Glu
`165
`
`Leu
`
`Glu
`
`Trp
`
`Asp
`
`Lys
`170
`
`Thr
`
`Glu
`175
`
`Thr
`
`Thr
`
`Gly
`180
`
`Trp
`
`Leu
`
`Ser
`
`Val
`
`His
`
`Gln
`210
`
`rp
`
`"95
`
`Jys
`
`"85 rp
`
`Ser
`
`Ser
`
`Asp
`
`Leu
`
`190
`
`Ile
`
`Thr
`
`Thr
`
`Gln
`
`Gln
`
`Gln
`
`Phe
`205
`
`Gln
`
`Asn
`
`Ser
`
`Glu
`200
`
`Gly
`
`Trp
`
`Asn
`215
`
`Pro
`
`Leu
`
`Ile
`
`Phe
`
`Thr
`
`Asp
`
`Asp
`220
`
`Leu
`
`Gly
`225
`
`Leu
`
`Ser
`
`Trp
`
`Ile
`
`Thr
`
`Thr
`
`Lys
`235
`
`Gly
`
`Arg
`240
`
`Phe
`
`Val
`
`Ser
`
`Gly
`245
`
`Pro
`
`Gly
`
`Val
`
`Gln
`250
`
`Phe
`
`Thr
`
`Ile
`
`Arg
`
`Leu
`255
`
`Ile
`
`Thr
`
`Asn
`
`Met
`260
`
`Pro
`
`Ala
`
`Val
`
`Ala
`
`Val
`265
`
`Gly
`
`Pro
`
`Asp
`
`Leu
`
`Leu
`
`Val
`
`Val
`270
`
`Pro
`
`Pro
`
`Ser
`
`Leu
`
`Ala
`
`Leu
`
`Pro
`
`Pro
`
`Pro
`
`Leu
`
`Pro
`
`Glu
`
`Gln
`
`Gly
`275
`
`Arg
`
`Thr
`
`280
`
`285
`
`Pro
`
`Arg
`290
`
`Glu
`
`Ala
`
`Pro
`
`Pro
`
`Ser
`
`Leu
`
`Pro
`
`Pro
`295
`
`Ser
`300
`
`Ser
`
`Thr
`
`Ala
`
`Ala
`
`Thr
`
`Ser
`
`Ala
`
`Leu
`305
`
`Gln
`310
`
`Thr
`
`Pro
`
`Thr
`
`Val
`
`Arg
`315
`
`Thr
`
`Ile
`
`Val
`
`Thr
`320
`
`Leu
`
`Asn
`
`Thr
`
`Pro
`
`Pro
`
`Pro
`
`Thr
`
`Thr
`
`Arg
`
`Leu
`
`Phe
`
`325
`
`330
`
`Leu
`
`Val
`
`335
`
`Gln
`
`Ala
`
`Phe
`340
`
`Leu
`
`Thr
`
`Leu
`
`Thr
`
`Pro
`
`Thr
`
`Glu
`
`Ser
`
`Trp
`355
`
`Leu
`
`Leu
`
`Ala
`
`Gly
`
`Pro
`
`Pro
`
`Met
`360
`
`Tyr
`365
`
`Glu
`
`Ala
`
`Ile
`
`Ala
`
`Ser
`
`Ser
`
`Glu
`
`Val
`
`370
`
`Tyr
`
`Ser
`
`Thr
`
`Ala
`375
`
`Leu
`
`380
`
`Arg
`
`Arg
`
`Trp
`
`Thr
`
`Gln
`
`Leu
`
`Thr
`
`Leu
`
`Thr
`
`Glu
`
`Val
`
`Ser
`
`His
`
`

`

`385
`
`390
`
`395
`
`400
`
`Leu
`
`Ile
`
`Gly
`
`Lys
`405
`
`Val
`
`Pro
`
`Phe
`
`Thr
`
`Gln
`
`His
`
`Leu
`
`His
`410
`
`Gln
`
`Asn
`415
`
`Thr
`
`Leu
`
`Ser
`
`Ile
`420
`
`Asn
`
`Ser
`
`Ser
`
`Gly
`
`His
`
`Gln
`
`Leu
`
`Leu
`
`Pro
`
`Ser
`
`425
`
`430
`
`His
`
`Ser
`435
`
`Trp
`
`Trp
`
`Ala
`
`Ser
`440
`
`Thr
`
`Leu
`
`Thr
`
`Pro
`445
`
`Leu
`
`Ser
`
`Thr
`
`(1
`oer
`
`450
`
`Val
`
`Phe
`
`Asn
`
`Gln
`
`Arg
`
`Thr
`455
`
`Phe
`
`Ile
`460
`
`Gln
`
`Val
`
`Gln
`
`Leu
`
`Pro
`
`Arg
`
`Ile
`
`Ile
`465
`
`Tyr
`470
`
`Pro
`
`Glu
`
`Glu
`
`Val
`475
`
`Leu
`
`Leu
`
`Gln
`
`Ala
`
`480
`
`Ser
`
`Arg
`
`Thr
`
`Pro
`485
`
`Arg
`
`Glu
`490
`
`Ala
`
`Val
`
`Ser
`
`Leu
`
`Leu
`
`Thr
`495
`
`Ala
`
`Val
`
`Leu
`
`Leu
`
`Ile
`
`Ala
`
`Ile
`
`Ser
`
`Leu
`500
`
`Gly
`
`Gly
`
`Thr
`505
`
`Gly
`
`Gly
`
`Thr
`510
`
`Gly
`
`Thr
`
`Ala
`
`Ile
`
`Leu
`
`515
`
`Pro
`
`Ile
`520
`
`Leu
`
`Gln
`
`Gln
`
`Gly
`525
`
`Leu
`
`Thr
`
`Ser
`
`Leu
`
`O ,_. :5
`(fl U.) Q
`
`Ile
`
`Ala
`
`Ile
`
`{1) ,_. S1)
`(fl 6) (fl
`
`Leu
`
`Arg
`
`Ala
`
`Leu
`540
`
`Gln
`
`Ser
`
`Val
`
`Ser
`545
`
`Leu
`
`Glu
`
`Asp
`
`Ser
`550
`
`Leu
`
`Thr
`
`Ser
`
`Leu
`
`Glu
`
`Val
`
`Val
`
`Leu
`
`Ser
`555
`
`Glr1
`560
`
`Asn
`
`Arg
`
`Arg
`
`Leu
`
`565
`
`Leu
`
`Leu
`
`Phe
`
`Leu
`
`570
`
`Glu
`
`Leu
`
`575
`
`Ala
`
`Ala
`
`Leu
`
`Glu
`
`Glu
`
`Phe
`
`Ile
`
`Ser
`590
`
`Ala
`
`Val
`
`Arg
`
`Ser
`
`Met
`
`595
`
`Leu
`600
`
`Glu
`
`Leu
`
`Arg
`
`Glr1
`
`Leu
`
`Glu
`610
`
`Arg
`
`Gln
`
`Ser
`
`Asn
`
`Gln
`615
`
`Glu
`
`Gly
`620
`
`Phe
`
`Asn
`
`Asn
`
`

`

`Ser Pro Trp
`625
`
`Phe Thr Thr Leu Leu
`630
`
`Ser
`
`Thr Ile
`635
`
`Ala Gly Pro Leu Leu
`640
`
`
`L u L u L u
`L u L u L u Il
`L u
`645
`
`Gly Pro Cys
`650
`
`Ile Ile Asn Lys Leu
`655
`
`Val Gln Phe
`
`Ile Asn Asp Arg Ile
`660
`
`Ser Ala Val
`665
`
`Lys Ile
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`10
`759
`DNA
`
`Artificial Sequence
`
`Homo
`
`sapiens
`
`<400>
`
`10
`
`atgatcgaga
`
`cctacaatca
`
`gacaagccca
`
`cggtccgccg
`
`caaccggact
`
`gcctatcagc
`
`atgaagatct
`
`tcatgtacct
`
`gctgaccgtg
`
`tttctgatca
`
`cacagatgat
`
`ngctccgcc
`
`ctgttcgccg
`
`tgtatctgca
`
`caggagactg
`
`gacaagatcg
`
`aggatgagcg
`
`caatctgcac
`
`gaggacttcg
`
`tgtttatgaa
`
`gaccatccag
`
`cggtgcaaca
`
`caggcgagag
`
`gagcctgtct
`
`ctgctgaatt
`
`gtgaggagat
`
`caagtcccag
`
`ttcgagggct
`
`ttgtgaagga
`
`tatcatgctg
`
`aacaaggagg
`
`agacaaagaa
`
`ggacgaggat
`
`ccacagatcg
`
`cagcacacgt
`
`ggtgtccgag
`
`gcaaactcta
`
`atgccgccag
`
`cgtgctgcag
`
`tgggccaaga
`
`agggctacta
`
`taccatgaag
`
`totaacctgg
`
`tgacactgga
`
`gaatggcaag
`
`cagctgaccg
`
`tgaagaggca
`
`gggcctgtac
`
`tatatctatg
`
`cccaggtgac
`
`attctgctct
`
`aacagagagg
`
`caagctccca
`
`ggcacccttc
`
`atcgtgggac
`
`tgtggctgaa
`
`gccctctagc
`
`ggcag
`
`60
`
`120
`
`180
`
`240
`
`300
`
`360
`
`420
`
`480
`
`