PATENT COOPERATION TREATY
`
`NPLZ
`
`PCT
`
`INTERNATIONAL PRELINIINARY REPORT ON PATENTABILITY
`(Chapter I of the Patent Cooperation Treaty)
`
`(PCT Rule 44bis)
`
`
`
`FOR FURTHER ACTION
`
`See item 4 below
`
`
`
`Applicant’s or agent’s file reference
`P16-1552WOOO
`
`
`International filing date (day/month/year)
`International application No.
`29 January 2018 (29.01.2018)
`PCT/JP2018/002797
`
`
`International Patent Classification (8th edition unless older edition indicated)
`See relevant information in Form PCT/ISA/237
`
`
`Applicant
`
`KAO CORPORATION
`
`Priority date (day/month/year)
`08 February 2017 (08.02.2017)
`
`This international preliminary report on patentability (Chapter I) is issued by the International Bureau on behalf of the
`International Searching Authority under Rule 44 bis.1(a).
`
`This REPORT consists of a total of 6 sheets, including this cover sheet.
`
`In the attached sheets, any reference to the written opinion of the International Searching Authority should be read as a
`reference to the international preliminary report on patentability (Chapter 1) instead.
`
`This report contains indications relating to the following items:
`
`the priority date (Rule 44bis .2).
`
`EDDEDDflg
`
`Box NO. I
`
`Box No. II
`
`Box No.
`
`Box NO.
`
`Box No.
`
`Box No.
`
`Box No.
`
`Box No
`
`Basis of the report
`
`Priority
`
`Non-establishment of Opinion with regard to novelty, inventive step and industrial
`applicability
`
`Lack of unity of invention
`
`invenLive step or
`Reasoned statement under Article 35(2) with regard to novelty,
`industrial applicability; citations and explanations supporting such statement
`
`Certain documents cited
`
`Certain defects in the international application
`
`Certain observations on the international application
`
`The International Bureau will communicate this report to designated Offices in accordance with Rules 44bis.3(c) and 93bis.1
`but not, except where the applicant makes an express request under Article 23(2), before the expiration of 30 months from
`
`
`Date of issuance of this report
`
`
`13 August 2019 (13.08.2019)
`
`Authorized Officer
`
`
`
`The International Bureau of WIPO
`34, chemin des Colombettes
`
` Mineko Mohri
`
`1211 Geneva 20, Switzerland
`Facsimile No. +41 22 338 82 7O
` e—mail: pct,tean18@wipo.int
`
`Form PCT/IB/373 (January 2004)
`
`

`

`WHENTCOOPERKHONTREATY
`
`INTERNATIONAL SEARCHING AUTHORITY
`
`From the
`T‘”
`
`2‘
`
`qus
`(4
`PCT
`
`7‘’0
`
`WRITTEN OPINION OF THE
`INTERNATIONAL SEARCHING AUTHORITY
`
`(PCT Rule 43bisi I)
`
`Applicant’s or agent's file reference
`P16—‘1552W000
`
`Date of mailing
`24.04.2018
`(@wmmem)
`FOR FURTHER ACTION
`See paragrapthelow
`
`International application No.
`
`International filing date (day/manth/year)
`
`Priority date (day/month/year)
`
`29.01.2018
`PCT/JP2018/002797
`International Patent Classification (IPC) or both national classification and IPC
`
`08.02.2017
`
`012N15/09(2006.01)i, C12N1/13(2006.01)i, C12N1/21(2006.01)i,
`C12N9/10(2006.01)i, C12P7/04(2006.01)i
`Applicant
`KAO CORPORATION
`
`
`
`This opinion contains indications relating to the following items:
`
`Box No. I
`
`Basis of the opinion
`
`Box No. II
`
`Priority
`
`Box No. III
`
`Non-establishment of opinion with regard to novelty, inventive step and industrial applicability
`
`Box No. IV
`
`Lack of unity of invention
`
`Box No. V
`
`Box No. VI
`
`Reasoned statement under Rule 43bir.l(a)(i) with regard to novelty, inventive step or industrial
`applicability; citations and explanations supporting such statement
`Certain documents cited
`
`Box No. VII
`
`Certain defects in the international application
`
`Box No. VIII
`
`Certain observations on the international application
`
`& D D D K
`
`4
`
`El
`
`D E
`
`]
`
`FURTHER ACTION
`
`this opinion will be considered to be a written opinion of the
`If a demand for international preliminary examination is made,
`International Preliminary Examining Authority (“IPEA”) except that this does not apply where the applicant chooses an Authority other
`than this one to be the IPEA and the chosen IPEA has notified the International Bureau under Rule 66.1bis(b) that written opinions of
`this International Searching Authority will not be so considered
`If this opinion is. as provided above, considered to be a written opinion of the IPEA, the applicant is invited to submit to the IPEA a
`written reply together, where appropriate, with amendments, before the expiration of 3 months from the date of mailing of Form
`PCT/ISA/ZZO or before the expiration of 22 months from the priority date, whichever expires later.
`For further options, see Form PCT/ISA/ZZO.
`
`Name and mailing address of the ISA/JP
`
`Date of completion of this opinion Authorized officer
`
`Facsimile No.
`
`Form PCT/ISA/237 (cover sheet) (January 2015)
`
`Telephone No.
`
`

`

`WRITTEN OPINION OF THE
`INTERNATIONAL SEARCHING AUTHORITY
`
`‘
`
`International application No.
`P CT / JP 2 O l 8 / O O 2 7 9 7
`
`
`
`
`Box No. I
`
`Basis of this opinion
`
`1. With regard to the language, this opinion has been established on the basis of:
`
`the international application in the language in which it was filed
`
`
`a translation of the international application into
`, which is the language of a
`
`
`translation furnished for the purposes of international search (Rules 12.3(a) and 23103)).
`
`
`
`forming part of the international application as filed:
`D in the form of an Annex C/ST.25 text file.
`[:1 on paper or in the form of an image file.
`
`
`This opinion has been established taking into account the rectification of an obvious mistake authorized by or notified to this
`Authority under Rule 91 (Rule 43bis.1(a))
`
`With regard to any nucleotide and/or amino acid sequence disclosed in the international application.
`this opinion has been
`
`
`
`established on the basis of a sequence listing:
`
`
`
`
`a I:
`
`
`
`
`
`In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements
`
`that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go
`beyond Lhe application as filed, as appropriate, were furnished.
`Additional comments:
`
`b D fumished together with the international application under PCT Rule lSter11(a) for the purposes of international search only in
`'
`the form of an Annex C/ST.25 text file.
`
`c. [:I
`
`furnished subsequent to the international filing date for the purposes of international search only:
`D in the form of an Annex C/ST.25 text file (Rule lBter.l(a)).
`D on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
`
`
`
`Form PCT/ISA/237 (Box No. 1) (January 2015)
`
`

`

`
`
`t‘ N.
`tt‘.l( 1‘
`hemamm‘mpwamn °
`WRHTENOPmHONOFTHE
`
`P CT / JP 2 O 1 8 / O 0 2 7 9 7
`INTERNATIONAL SEARCHING AUTHORITY
`
`Reasoned statement under Rule 43bis.1(a)(i) with regard to novelty, inventive step or industrial applicability;
`
`citations and e - lnnntions su v
`- ortin such statement
`
`1.
`Statement
`
`
`Novelty (N)
`Claims
`
`
`Claims
`
`
`Inventive step (IS)
`Claims
`1 — l 2
`YES
`
`
`Claims
`
`
`Industrial applicability (IA)
`Claims
`
`
`Claims
`
`2.
`
`
`
`Citations and explanations:
`
`
`
`
`Document 1:
`WO 2015/133305 A1
`(KAO CORP.)
`11 September
`
`
`
`2015,
`[0003],
`[0015],
`[0042],
`paragraphs
`
`
`[0052],
`comparative example 2
`& US
` [0035],
`
`
`
`
`2017/0044580 A1,
`paragraphs [0004],
`
`
`
`
`
`
`[0109],
`[0110],
`[0084],
`[0085],
`comparative
`
`example 2
`
`Document 2: DOMERGUE F. et al., "Three Arabidopsis
`
`
`fatty acyll—coenzyme A reductases, FARl,
`
`
`FAR4, and PARS, generate primary fatty
` Plant Physiol.,
`
`table 11
`
`alcohols associated with suberin
`
`
`
`2010, vol.
`deposition",
`
`153, pages 1539—1554,
`
`Document 3: DOAN T.T. et al., Functional expression of
`
` genes in Escherichia coli, J. Plant
`
`
`
`
`Physiol., 2009, vol. 166, pages 787—796,
`
`4
`fig.
`
`Document 4:
`conversion of carbon dioxide to fatty
`
`five Arabidopsis fatty acyl—COA reductase
`
`TAN X. et al., Photosynthesis driven
`
`alcohols and hydrocarbons in cyanobacteria,
`
`
`Metab. Eng., 2011, vol. 13, pages 169-176,
`
`Form PCT/ISA/237 (Box No. V) (January 2015)
`
`

`

`Intemauonal application No.
`WRITTEN OPINION OF THE
`PCT/JP2018/002797
`mnmmxnomusuumeGAUnmRHY
`Reasnned statement under Rule 43bis.1(a)(i) with regard to novelty, inventive step or industrial applicability;
`
`
`
`citations and ex lunatiuns su nortin such statement
`
`Claims 13—19
`
`The invention as in claims 13-19 of the present
`
`application does not
`
`involve an inventive step in the
`
`light of documents 1—4 cited in the ISR.
`
`Document
`
`1 describes a strain of E. coli that was
`
`transfected with a gene coding for NoKAS I or NoKAS II
`
`(SEQ ID NO: 60) originating Nannochloropsis oculata, and
`
`a method for producing a lipid using said E. coli.
`
`Document
`
`1 further states the following:
`
`that the term
`
`lipids includes fatty acids and alcohols that are derived
`
`from lipids;
`
`that higher alcohol derivatives that are
`
`obtained by reducing higher fatty acids can be utilized
`
`as surfactants;
`
`that KAS I is mainly involved in
`
`elongation to Cm palmitoyl~ACP, and KAS II is mainly
`
`involved in elongation to Cm stearoyl—ACP; and that
`
`microalgae can be utilized as a host
`
`(paragraphs [0003],
`
`[0015],
`
`[0042],
`
`[0052]; comparative example 2).
`
`Furthermore,
`
`the amino acid sequence of SEQ ID NO:
`
`60
`
`described in document
`
`I has 89% identity with the amino
`
`acid sequence of SEQ ID NO:
`
`1 of the present application,
`
`and 97% identity with the amino acid sequence of SEQ ID
`
`NO:
`
`96 of the present application.
`
`In this case, document
`
`1 does not describe the use
`
`of the fatty acid acyl—CoA reductases specified in (G)
`
`to
`
`(R) of claim 13 of the present application.
`
`However, document
`
`1 states that higher alcohols
`
`obtained by reducing higher fatty acids are useful as
`
`surfactants, etc. Furthermore, as described in documents
`
`2—4
`
`(document 2:
`
`table II, etc., document 3: figure 4,
`
`etc., document 4: figure 4, etc.), it is known that
`
`Form PCT/ISA/237 (Box No. V) (January 2015)
`
`

`

`‘ N OPINION OF THE
`WRI
`INTERNATIONAL SEARCHING AUTHORITY
`
`Internanona] application No.
`P CT / JP 2 O 1 8 / O O 2 7 9 7
`
`Reasoned statement under Rule 43bis.1(a)(i) with regard to novelty, inventive step or industrial applicability; citations and
`
`I lunntions su I Iortin such statement
`
`alcohols can be produced by reducing fatty acids with a
`
`reductase such as FARl
`
`from Arabidopsis thaliana.
`
`Therefore,
`
`a person skilled in the art could have easily
`
`conceived of using a known reductase such as FAR1 from
`
`Arabidopsis thaliana to obtain a useful higher alcohol
`
`in
`
`the invention described in document 1.
`
`Furthermore,
`
`the invention of claims 13-19 of the
`
`present application cannot be considered to exhibit a
`
`particularly prominent advantageous effect that could not
`
`be predicted when compared with the inventions as
`
`understood from the descriptions in documents 1—4.
`
`As a result, a person skilled in the art could have
`
`easily accomplished the invention of claims 13-19 of the
`
`present application based on the invention described in
`
`document
`
`1 and the technical matters described in
`
`documents 2—4.
`
`Claims 1—12
`
`The invention as in claims 1-12 is novel and
`
`involves an inventive step in relation to documents 1—4
`
`cited in the ISR.
`
`Documents 1—4 describe the subject matter discussed
`
`above.
`
`However, none of documents 1~4 indicates that a
`
`long—chain fatty acid alcohol comprising a fatty acid
`
`alcohol of at least 20 carbon atoms can be produced using
`
`a microorganism transfected with a gene that codes for
`
`the B—keto acyl~ACP synthases identified in (A)
`
`to (F) of
`
`claim 1 of the present application, and such a matter
`
`cannot be considered obvious to a person skilled in the
`
`art.
`
`Form PCT/ISA/237 (Box No. V) (January 2015)
`
`

`

`PATENT COOPERATION TREATY
`
`PCT
`
`INTERNATIONAL PRELIIVIINARY REPORT ON PATENTABILITY
`(Chapter I of the Patent Cooperation Treaty)
`
`Applicant’s or agent’s file reference
`P16-1552WOOO
`
`(PCT Rule 44bis)
`
`
`
`FOR FURTHER ACTION
`
`See item 4 below
`
`International filing date (day/motitli/year)
`International application No
`29 January 2018 (29.01.2018)
`PCT/JP2018/002797
`International Patent Classification (8th edition unless older edition indicated)
`See relevant informationIn Form PCT/iSA/237
`
`Priority date (day/month/year)
`08 February 2017 (08. 02.2017)
`
`Applicant
`KAO CORPORATION
`
`
`
`
`
`
`
`
`
`
`
`This international preliminary report on patentability (Chapter I) is issued by the International Bureau on behalf of the
`International Searching Authority under Rule 44 bis.1(a).
`
`This REPORT consists of a total of 5 sheets, including this cover sheet.
`
`In the attached sheets, any reference to the written opinion of the International Searching Authority should be read as a
`reference to the international preliminary report on patentability (Chapter 1) instead.
`
`This report contains indications relating to the following items:
`
`EDI]EC!Dljfi
`
`Box No. I
`
`Box No. 11
`
`Box No.
`
`Box No.
`
`Box No.
`
`Box No.
`
`Box No.
`
`Box No.
`
`Basis of the report
`
`Priority
`
`Non-establishment of opinion with regard to novelty, inventive step and industrial
`applicability
`
`Lack of unity of invention
`
`Reasoned statement under Article 35(2) with regard to novelty, inventive step or
`industrial, applicability; citations and explanations supporting such statement
`
`Certain documents cited
`
`Certain defects in the international application
`
`Certain observations on the international application
`
`
`
`The International Bureau will communicate this report to designated Offices in accordance with Rules 44bis.3(c) and 93bis.1
`but not, except where the applicant makes an express request under Article 23(2), before the expiration of 30 months from
`the priority date (Rule 44bis .2).
`
`The International Bureau of WIPO
`34, chemin des Colombettes
`1211 Geneva 20, Switzerland
`Facsimile No. +41 22 338 82 70
`
`Form PCT/IB/373 (January 2004)
`
`Date of issuance of this report
`13 August 2019 (13.08.2019)
`
`Authorized officer
`
`-
`.
`M I neko MOh Fl
`e-mail: pct.team8@wipo.int
`
`

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`
`[00151
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`FARl, PAR4, and PARS, generate primary fatty alcohols associated with
`suberin deposition, Plant Physiol., 2010, Vol.153, pp. 1539-1554,
`i?
`11
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`
`acyl—CoA reductase genes in Escherichia coli, J. Plant Physiol. , 2009,
`Vol. 166, pp. 787*796,
`[>2] 4
`
`: TAN X. et al., Photosynthesis driven conversion of carbon dioxide to
`
`fatty alcohols and hydrocarbons in cyanobacteria, Metab. Eng., 2011,
`Vol.13, pp. 169-176,
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