`' ”At'tettnev DOCKET he,
`
`TNANSMETTAL LETTER TC) THE UNETED STATES
`QESEGNATEDIELEQTEN QFFECE (DQIEQIUS)
`CQNCENNENG A SUBMESSEQN UNDER 35 USS 37'1
`
`28Q363
`CLiENT REFFRENCE NO
`P? 1 :1 1&433359
`u“3“nnptiemien‘ho {iiiEEiBwn see 37 we???“
`
`NTERNATIONALAW ““““ ihTERNAWTE
`
`PCT}N{1.2% 71’953???
`
`W! Nevemhetzewt7
`
`PREORH‘Y DATEGLAiMED
`
`Nevemhet25 23‘?6
`
`TiiLE OF‘NW'NWEN
`QUANTETATEVE RETENAt: EMAGENG
`APPLECANTQ“)FOR DOZEO'US
`NEQERLANQSE QRGANESA‘E‘EE VQQR TGEGENASTNATUURWETENSCHAPPELNK
`QNQERZQEK TNQ
`“‘Apniieent herewith submitstothe United States DeSignetediEiected CNee (DOIEQiUS) the feiiewmg items andether
`tntermetien:
`
`
`
`?
`
`E
`
`_
`1
`
`:
`
`i.
`
`2,
`
`3.
`
`4.
`
`5.
`
`S.
`
`"a
`
`This is a HRS? submission of items neneerning e tiiing under 35 USS 3'31 and 3? (it—"R 1.493.
`
`E} This is e SECGNQ or $UBSEQ£§ENT submission of items cementing e tiiing under 35 USS 37’1 end 37 CFR 1.491
`
`[:1 This is an express request to begin netienei exeminetien procedures (35 USC 371th).
`
`[3 The US has been eteeted (PCT Artiste St) in e Chapter it Etemenct tiied during the intetnetienei phase.
`
`$14 A copy et the internetienei Aneiicetien es tiiect (35 USS 371(c)(2))
`a.
`E} is attached herete (required enty it net cemmuniceted hy the tnternetienei Bureau)
`h.
`514% has been communicated by the tnternetienei Bureeu
`c.
`{:3
`is net required as the eppiicetien was tiied in the United States Receiving Ottiee {ROMS}
`
`E} An Engtish iengnege trensietien of the tntetnetienei Appiieetien es tiied (35 USS 371(c)(2};
`e.
`C}
`is attechee herete.
`h,
`if] hes previousiy been submitted under 35 U.S.C. t54td)t4).
`
`[:3 Amendments tn the eieime et the internetienei Appiieetien under PCT Artieie 19 (35 USC 371(c)(3))
`e.
`E} are attached herete (required eniy it net eemmuniceted hy the tntetnetienei Bureau).
`h
`[3 have been communicated by the tnternetienei Bureau
`:2.
`[:i have not been made; hewever the time iimit ter making such amendments hee N0"? expired
`d
`[3 have net been matte end wiii net he matte.
`
`8. C] An Engiish ienguege trenstetion of the amendments to the eieims tinder PCT Artiste 19 (35 USC 3?‘i(c)(3))
`
`9.
`
`iii
`
`tnventer deeieretion(s) (35 USS 371(c)(4))
`
`it): E} An Engiieh tanguage trensietien of the annexes to the internetienei Pretiminaty Examination Renen under PCT
`Artiste 35 (35 USC 371(c)(5))
`
`’i‘i. Nucieetide end/er Amine Acid Sequence Suhmissien
`e. E] Cementer Reedehie Fenn (SR?)
`
`12. X An information Diseiesure Statement under 3? CFR 1.9? end 138
`Form PTOn‘iztxtt)
`>14 Ceeies of References (except for ties. eetents end apeiieetiens)
`
`13
`
`A FiRST eteiiminety amendment
`
`ti A SEGONQ erSUb‘xKQUENTpttiiii‘ninxsyementtment“
`
`US Natienei Phase Trensmittai
`
`Page 1 its? 3
`
`

`

`U.S APPLICATEON NO (1,1kz1cw11 see 37' CFR.1 5)
`______________________
`
`ATTORNEY DOCKET Ne
`
`E ENTERNATIONAL APPUCATEON NO.
`
`28%53
`‘EQTINLZG’EWQESGWZ
`1
`P1 111041231110
`
`
`13115111 REFERENCE NO,
`
`15. 1:1 Subsfitute Speeifieetien
`
`‘16.
`
`1?.
`
`Power 01151111311111);
`
`Appticetien Data Sheet Under 37’ CFR 1.176
`
`‘18.
`[:1 cher items or infermetien:
`
`
`5;;_::.::.:.:_::
`
`
`
`CALCULATmm
`
`1111.1.-w."""" 3.51) 1311
`
`
`PTO USE QNLY
`
`=
`
`52
`
`$763 {)9 1
`'
`,,,,,,
`
`it
`3
`'1
`
`$52G QC?
`
`1“,...
`
`1
`5 i
`$
`$2559
`
`~
`
`i
`
`:
`
`The foiiewing fees are submitted:
`.§1_e_.___ E 1311.111:11811031111331?CPR 1 492(3))
`
`""""
`213. l fixéifiinaflon Fee (3? CFR 14112111))
`if Entemaflenei preiimmery exeminetien 119131.111 prepared by USPTO and 3111 ciaims satisfy
`12110111510115 of PCT ArticEe 33(1)(4) .......................................................................
`\WEOHS“.31._.5.1!).__"1_._.1f.LAAfA‘.'.Z3.3.23.1";
`'
`‘
`'
`‘
`
`'
`21 I Search Fee
`if the written 0111111111 13111111 ESAIUS or the 1n1err1et1ene1 11111111111531}; ex1111111‘1efie11 11111-1111 11111111111111
`by BPENUS 1111111331515 2111 111811115 satisfy provisions (21‘ 1‘18? 1511118311 3'10)(432
`$
`£1
`11311101131151:
`811211
`
`Search seaport provided 11:1 USPTQ by 11111111-81111131
`.
`.
`.
`.
`.
`.
`..
`“111111911161 situafions .....::::::.:::.:::::.:. . . .
`. . . . . . . . . . .. .:_._.1:33;.
`
`
`1:} Addétionat fee 191‘ epptirzation and 1:11311111’111511‘1~ ted111 paper over 155 sheets (exciuding
`3' sequence tistttng or computer pregrem iisting flied111 an etectremc medium) The fee13 $4211 1111
`:‘eg‘chm3111111101131 55 eheetggofpaper9111111811011 thereof
`Totat Sheets
`1W:Extra Sheets;
`1 Number 51' each 3111111110531501211 11111211011
`1
`“100:1
`1511m 1
`
`1111110110111191212111.111111911111111112.11sz
`
`:
`
`\\\
`
`,,
`
`“am
`
`
`
`
`$1 581:1{)Q
`13111101111110 be:
`refuegiegzfi
`V ..11111131111110 be
`
`$
`
`$
`
`"
`
`
`
`
`----------
`
`SLAMS
`
`Tote! 1231111111
`
`
`
`\\\wm\\\\\\\
`. “g.
`1
`
`Processmg fee (1121411 for furnishing 13111111111 Transiatien 1318111111111 30 menthsfrom the
`3
`
`u‘eerimedenemydate
`.........
`
`‘TWALsee:
`\\\
`
`3 13 Qne~menth extensien of tfime tee 013112.05
`«\WWWWW3»M““ :
`113:1 Petitiee fer e111 11111111111111 1:11 time (11112111111119 the period meted ebeve if checked) es '
`weit es for any 35111111311111 peried necessary 11) render the present 31151111331011 t1me1y.
`Pteeee eheggge136mm1611112011111 No :12121531191111g39111}.111111111:eet1tie1jtee _____
`11112111. 1:251:E111 Lessee-
`
`
`
`euemmm
`
`US 11111101181 Phase Trensmfitet
`
`Page 2 C11c 3
`
`

`

`US. APPUCATEON NO‘ (if known. 553-3 37 CFR 15)
`
`ENTERNATEONAL AE’PLECATECEN NO.
`: PCTINLZG‘EYIGEG7YE
`
`ATF‘ORNEY DQCKET NO.
`283383
`
`V
`
`CLEENT REF NO.
`
`a.
`
`b.
`
`: c.
`
`{:1 N0 fee iS beiieved is be due.
`
`Piease charge BepmitAccauni Na. 124215 the £01135er inaicated abeve.
`
`The Ccmmissioner is hereby autharized ta charge any additianai €933 which may be required 0r credit any
`overpayment ta Depfisit Amount Ne. 124215.
`
`NGTE: Where an appmmiate time Eémit under 3? CFR “3.494 m" 1.4% has net been mm, a gamma tea revive (3'?
`5 CFR 1.13fla) 0;“ (hi) misfit ha flied anti granted ta resmre {ha aypiiaaticn m pemfing statam.
`
`i May 22,2919
`
`CORRESPONDENCE ADDRESS
`
`Custemer N0. 23483
`
`Name
`
`Mark Jay, Reg. No. 35,562
`
`Signature
`
`Centact.
`inffifmaiififi
`
`‘
`
`.
`
`‘_
`
`1,
`
`..
`
`I
`
`35
`
`Teaephanez
`Facsimiie:
`
`3’52—516—56GQ
`312v518~5m£§
`
`US Naiianai Phase Transmitiai
`
`Rage 3 Q? 3
`
`