_ 2 _
`
`CAI et a].
`
`Application No. T0 be Assigned
`
`Amendments to the Specification
`
`Please amend pages 15-28; paragraph [0068] of the English language translation as follows:
`
`In one or more of the foregoing embodiments, preferred compounds of Formula I include, without
`
`limitation:
`
`6-(2-Chlorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 1);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 2);
`
`4-(2-Chlorophenyl)-8-((4-(4-methylpiperazin-l-yl)phenyl)amino)-2;4-dihydroimidazo[1,2-
`
`a]pyrido[3,4-e]pyrimidin-5(1H)-one (Example 3);
`
`6-(2;6-Dichlorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 4);
`
`6-(2-Chloro-6-methylphenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 5);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 6);
`
`2-((4-(4-Acetylpiperazin-l-yl)phenyl)amino)-6-(2-chloro-6-fluorophenyl)—8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 7);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2-methyl-l,2;3,4-tetrahydroisoquinolin-7-yl)amino)-8,9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 8);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2;4,4-trimethyl-l,2;3,4-tetrahydroisoquinolin-7-yl)amino)-
`
`8,9-dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 9);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2'-methyl-2';3'-dihydro-1'H-spiro[cyclopropane-1,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`10);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2'-acetyl-2';3'-dihydro-l'H-spiro[cyclopropane-l,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`7
`1 1)
`
`Atty. Dkt. No. 3386.0100002
`
`
`
`CAI et a].
`
`Application No. T0 be Assigned
`
`Amendments to the Specification
`
`Please amend pages 15-28; paragraph [0068] of the English language translation as follows:
`
`In one or more of the foregoing embodiments, preferred compounds of Formula I include, without
`
`limitation:
`
`6-(2-Chlorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 1);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 2);
`
`4-(2-Chlorophenyl)-8-((4-(4-methylpiperazin-l-yl)phenyl)amino)-2;4-dihydroimidazo[1,2-
`
`a]pyrido[3,4-e]pyrimidin-5(1H)-one (Example 3);
`
`6-(2;6-Dichlorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 4);
`
`6-(2-Chloro-6-methylphenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 5);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 6);
`
`2-((4-(4-Acetylpiperazin-l-yl)phenyl)amino)-6-(2-chloro-6-fluorophenyl)—8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 7);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2-methyl-l,2;3,4-tetrahydroisoquinolin-7-yl)amino)-8,9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 8);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2;4,4-trimethyl-l,2;3,4-tetrahydroisoquinolin-7-yl)amino)-
`
`8,9-dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 9);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2'-methyl-2';3'-dihydro-1'H-spiro[cyclopropane-1,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`10);
`
`6-(2-Chloro-6-fluorophenyl)-2-((2'-acetyl-2';3'-dihydro-l'H-spiro[cyclopropane-l,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`7
`1 1)
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`Atty. Dkt. No. 3386.0100002
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`_ 3 _
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`CAI er a].
`
`Application No. T0 be Assigned
`
`6-(2;6-Dichlorophenyl)-2-((2-methyl-1;2;3 ,4-tetrahydroisoquinolin-7-yl)amino)—8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 12);
`
`6-(2;6-Dichlorophenyl)—2-((2;4,4-trimethyl-1,2;3 ,4-tetrahydroisoquinolin-7-yl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 13);
`
`6-(2;6-Dichlorophenyl)-2-((2'—methyl-2';3'-dihydro-1'H-spiro[cyclopropane-1,4'—isoquinolin]—
`
`7'-yl)amino)—8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 14);
`
`6-(2;6-Dimethylphenyl)-2-((2-methyl-1,2,3 ,4-tetrahydroisoquinolin-7-yl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 15);
`
`6-(2;6-Dimethylphenyl)-2-((2;4;4-trimethyl-1;2;3 ,4-tetrahydroisoquinolin-7-yl)amino)—8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 16);
`
`6-(2;6-Dimethylphenyl)—2-((2'-methyl-2';3'-dihydro-1'H-spiro[cyclopropane-1,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`17);
`
`6-Isopropyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-dihydroimidazo[1;2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 18);
`
`6-(Tert-butyl)—2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-dihydroimidazo[1;2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 19);
`
`6-Cyclopropyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 20);
`
`6-Cyclohexyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-dihydroimidazo[1;2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 21);
`
`6-Allyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-dihydroimidazo[1;2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 22);
`
`2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-6-(thiophen-2-yl)-8;9-dihydroimidazo[1;2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 23);
`
`6-(Furan-2-yl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 24);
`
`2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-6-(1H-pyrrol-2-yl)-8;9-dihydroimidazo[1;2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 25);
`
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`Application No. T0 be Assigned
`
`6-(1H-Imidazol-S-yl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 26);
`
`6-(2-Chloro—6-fluorophenyl)—8;8-dimethyl-2-((4-(4-methylpiperazin- l -yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 27);
`
`6-(2-Chloro—6-fluorophenyl)—8;8-dimethyl-2-((4-(4-methylpiperazin- l -yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 28);
`
`6-(2-Chloro—6-fluorophenyl)-2-((4-((2S;6R)-2;6-dimethylmorpholino)phenyl)amino)-8,9-
`
`dihydroimidazo[l;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 32);
`
`6-(2-Chloro—6-fluorophenyl)-2-((4-(morpholinomethyl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 3 3);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((3 S;5R)-3 ,4;5-trimethylpiperazin-1-yl)phenyl)amino)—
`
`8,9-dihydroimidazo[l;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 34);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((3 S; 5R)—4-isopropyl-3 ; 5-dimethylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 3 5);
`
`6-(2-Chloro—6-fluorophenyl)-2-((2-fluoro-4-(4-methylpiperazin- l -yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 36);
`
`6-(2-Chloro—6-fluorophenyl)-2-((2-fluoro—4-((3 S; 5R)-3 ,4;5-trimethylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 37);
`
`6-(2-Chloro—6-fluorophenyl)-2-((2-chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 38);
`
`6-(2-Chloro—6-fluorophenyl)-2-((2-chloro—4-((3 S;5R)-3 ,4;5-trimethylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 39);
`
`6-(2-Chloro—6-fluorophenyl)—2-((4-(4-methylpiperazin-1-yl)—2-
`
`(trifluoromethyl)phenyl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one
`
`(Example 40);
`
`6-(2-Chloro—6-fluorophenyl)-2-((2-trifluoromethyl-4-((3 S; 5R)-3 ,4; 5 -trimethylpiperazin- l -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 41);
`
`6-(2-Chloro—6-fluorophenyl)-2-((2-methyl-4-(4-methylpiperazin- l -yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 42);
`
`Atty. Dkt. No. 3386.0100002
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`Application No. T0 be Assigned
`
`6-(2-Chloro-6-fluorophenyl)-2-((2-methyl-4-((3 S;5R)-3 ;4;5-trimethylpiperazin-1-
`
`yl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 43);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -fluoro—4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 44);
`
`6-(2-Chloro—6-fluorophenyl)—2-((3 -fluoro-4-((3 S;5R)-3 ,4; 5-trimethylpiperazin-1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 45);
`
`6-(2-Chloro-6-fluorophenyl)-2-((3 -chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 46);
`
`2-((3 -Chloro—4-((3 S;5R)-3 ;4;5-trimethylpiperazin- l -yl)phenyl)amino)—6-(2-chloro-6-
`
`fluorophenyl)—8,9-dihydroimidazo[ l ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 47);
`
`6-(2-Chloro—6-fluorophenyl)—2-((4-(4-methylpiperazin- l -yl)—3 -
`
`(trifluoromethyl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one
`
`(Example 48);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -trifluoromethyl-4-((3 S; 5R)-3 ,4; 5 -trimethylpiperazin- l -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 49);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 50);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -methyl-4-((3 S;5R)-3 ;4;5-trimethylpiperazin-1-
`
`yl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 51);
`
`6-(2-Chloro—6-fluorophenyl)—2-((4-(4-isopropylpiperazin- l -yl)—3 -methylphenyl)amino)—8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 52);
`
`6-(2-Chloro-6-fluorophenyl)—2-((4-((3 S; 5R)-4-isopropyl-3 ,5-dimethylpiperazin-1-yl)—3 -
`
`methylphenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example
`
`53);
`
`6-(2-Chloro-6-fluorophenyl)-2-((3 -methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 54);
`
`6-(2-Chloro—6-fluorophenyl)-2-((4-(4-methylpiperazin- l -yl)—3 -nitrophenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 55);
`
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`6-(2-Chloro—6-fluorophenyl)-2-((3 ; 5-dimethyl-4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 56);
`
`6-(2-Chloro—6-fluorophenyl)-2-((6-(4-methylpiperazin- l -yl)pyridin-3 -yl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 57);
`
`6-(2-Chloro—6-fluorophenyl)-2-((2'-isopropyl-Z';3 '-dihydro- l 'H-spiro[cyclopropane- l ,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`5 8);
`
`6-(2-Chloro—6-fluorophenyl)-2-((5-methyl-4; 5,6;7-tetrahydropyrazolo[1,5-a]pyrazin-2-
`
`yl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 59);
`
`6-(2; 6-Difluorophenyl)-2-((3 -methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8; 9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 60);
`
`6-(2 -Fluoro-6-(trifluoromethyl)phenyl)-2-((3 -methyl-4-(4-methylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 61);
`
`6-(2-Fluoro-6-methylphenyl)-2-((3 -methyl-4-(4-methylpiperazin- l -yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 62);
`
`6-(2;6-Dichlorophenyl)—2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 63);
`
`6-(2;6-Dichlorophenyl)-2-((4-((3 S; 5R)-3 ,4;5-trimethylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 64);
`
`6-(2;6-Dichlorophenyl)—2-((4-((3 S;5R)-4-isopropyl-3 ,5-dimethylpiperazin-1-
`
`yl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 65);
`
`6-(2;6-Dichlorophenyl)-2-((2-fluoro-4-((3 S; 5R)-3 ,4;5-trimethylpiperazin-1-yl)phenyl)amino)—
`
`8,9-dihydroimidazo[1 ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 66);
`
`6-(2;6-Dichlorophenyl)-2-((2-chloro—4-((3 S; 5R)-3 ,4;5-trimethylpiperazin-1-yl)phenyl)amino)-
`
`8,9-dihydroimidazo[1 ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 67);
`
`6-(2;6-Dichlorophenyl)—2-((2-trifluoromethyl-4-((3 S; 5R)-3 ,4;5-trimethylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 68);
`
`6-(2;6-Dichlorophenyl)—2-((3 -fluoro—4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 69);
`
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`6-(2,6-Dichlorophenyl)-2-((3 -fluoro-4-((3 S, 5R)-3 ,4,5-trimethylpiperazin-1-yl)phenyl)amino)—
`
`8,9-dihydroimidazo[1 ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 70),
`
`6-(2, 6-Dichlorophenyl)—2-((3 -chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8,9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 71),
`
`6-(2, 6-Dichlorophenyl)—2-((3 -chloro—4-((3 S, 5R)-3 ,4, 5 -trimethylpiperazin- l -yl)phenyl)amino)-
`
`8,9-dihydroimidazo[1 ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 72),
`
`6-(2, 6-Dichlorophenyl)—2-((4-(4-methylpiperazin-1-yl)—3 -(trifluoromethyl)phenyl)amino)-8, 9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 73),
`
`6-(2, 6-Dichlorophenyl)—2-((3 -trifluoromethyl-4-((3 S, 5R)-3 ,4, 5 -trimethylpiperazin- l -
`
`yl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 74),
`
`6-(2,6-Dichlorophenyl)-2-((3 -methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)—8,9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 75),
`
`6-(2,6-Dichlorophenyl)—2-((4-(4-isopropylpiperazin- l -yl)—3 -methylphenyl)amino)-8,9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 76),
`
`6-(2,6-Dichlorophenyl)—2-((3 -methyl-4-((3 S,5R)-3 ,4, 5-trimethylpiperazin-1 -
`
`yl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 77),
`
`6-(2,6-Dichlorophenyl)—2-((4-((3 S,5R)-4-isopropyl-3 ,5-dimethylpiperazin-1-yl)-3 -
`
`methylphenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`78),
`
`6-(2,6-Dichlorophenyl)—2-((5-methyl-4,5,6,7-tetrahydropyrazolo[ l , 5-a]pyrazin-2-yl)amino)-
`
`8,9-dihydroimidazo[1 ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 79),
`
`6-(2-Chloro-6-(trifluoromethyl)phenyl)-2-((3 -methyl-4-(4-methylpiperazin-1-
`
`yl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 80),
`
`6-(2-Chloro—6-methylphenyl)—2-((3 -methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8,9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 81),
`
`6-(2-Chloro—6-methoxyphenyl)-2-((3 -methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)—8, 9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 82),
`
`6-(2,6-Dimethylphenyl)—2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8,9-
`
`dihydroimidazo[l,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 83),
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`6-(2;6-Dimethylphenyl)-2-((4-((3 S; 5R)-3 ,4;5-trimethylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 84);
`
`6-(4-Chlorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 85);
`
`6-(3 -Chlorophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 86);
`
`6-(2;4-Dichlorophenyl)—2-((4-(4-methylpiperazin- l -yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 87);
`
`6-(2-Chloro—4-fluorophenyl)-2-((4-(4-methylpiperazin- l -yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 88);
`
`6-(2-Chloro—3 -fluorophenyl)-2-((4-(4-methylpiperazin- l -yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 89);
`
`6-(2; 5 -Dichlorophenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8; 9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 90);
`
`6-(2; 3 -Dichlorophenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8; 9-
`
`dihydroimidazo[ l ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 91);
`
`6-(Pyrimidin-2-yl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 92);
`
`2-((4-(4-Methylpiperazin- l -yl)phenyl)amino)-8;9-dihydroimidazo[ l ,2-a]pyrimido[5;4-
`
`e]pyrimidin-5(6H)-one (Example 93);
`
`6-Cyclobutyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)—8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 94);
`
`6-Cyclopentyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 95);
`
`6-Phenyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 96);
`
`6-(Pyridin-2-yl)—2-((4-(4-methylpiperazin-l-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 97);
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`6-(Pyridin-3 -yl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 98);
`
`6-(Pyridin-4-yl)—2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 99);
`
`6-(2;6-Difluorophenyl)-2-((3-chloro—4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 100);
`
`6-(2;6-Difluorophenyl)-2-((3 ;5-dimethyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 101);
`
`6-(2-Chloro—6-fluorophenyl)-2-((4-(1H-imidazol-1-yl)phenyl)amino)-8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 102);
`
`6-(2-Chloro—6-fluorophenyl)-2-((4-(4-methyl-1,4-diazepan-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ 1 ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 103);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 104);
`
`6-(2-Chloro—6-fluorophenyl)-2-((4-(2-(dimethylamino)ethoxy)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 105);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(3-(dimethylamino)propoxy)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 106);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 107);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((2-(dimethylamino)ethyl)amino)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 108);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)amino)-
`
`8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 109);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((3 -(dimethylamino)propyl)amino)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 1 10);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-((3 -(dimethylamino)propyl)(methyl)amino)phenyl)amino)—
`
`8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 111);
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`6-(2-Chloro-6-fluorophenyl)-2-((4-((1-methylpiperidin-4-yl)amino)phenyl)amino)—8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 1 12);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(methyl(1-methylpiperidin-4-yl)amino)phenyl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 1 13);
`
`6-(2-Chloro—6-fluorophenyl)-2-((4-(1-methylpiperidin-4-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 1 14);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 1 15);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)-3 -fluorophenyl)amino)-
`
`8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 116);
`
`6-(2-Chloro—6-fluorophenyl)—2-((3 -chloro-4-(4-(dimethylamino)piperidin-1-yl)phenyl)amino)-
`
`8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 117);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -bromo-4-(4-(dimethylamino)piperidin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 1 18);
`
`6-(2-Chloro-6-fluorophenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)-3 -
`
`methylphenyl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`1 19);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -fluoro-5-methyl-4-(4-(dimethylamino)piperidin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 120);
`
`6-(2-Chloro-6-fluorophenyl)-2-((5 -(4-methylpiperazin-1-yl)pyrazin-2-yl)amino)-8; 9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 121);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 ; 5 -dichloro—4-(4-methylpiperazin-1-yl)phenyl)amino)—8; 9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 122);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -fluoro-5-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)—
`
`8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 123);
`
`6-(2-Chloro—6-fluorophenyl)—2-((3 -fluoro-5-methoxy-4-(4-methylpiperazin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 124);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -chloro—5-methyl-4-(4-methylpiperazin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 125);
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`6-(2-Chloro—6-fluorophenyl)-2-((3 -chloro—5-methoxy-4-(4-methylpiperazin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 126);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -bromo-5-methoxy-4-(4-methylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 127);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -methyl-4-(4-methylpiperazin-1-yl)-5-
`
`(trifluoromethyl)phenyl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one
`
`(Example 128);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -methoxy-5-methyl-4-(4-methylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 129);
`
`6-(2;6-Dichlorophenyl)—2-((5-chloro—2-methyl- 1 23 ,4-tetrahydroisoquinolin-7-yl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 13 O);
`
`7
`7
`7
`6-(2;6-Dichlorophenyl)—2-((2;5-dimethyl- 1 2 3 4-tetrahydroisoquinolin-7-yl)amino)-8,9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 131);
`
`
`
`6-(2;6-Dichlorophenyl)-2-((2;4;4;5-tetramethyl-1;2;3 ,4-tetrahydroisoquinolin-7-yl)amino)-
`
`8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 13 3);
`
`6-(2;6-Dichlorophenyl)—2-((5'-chloro—2'-methyl-2';3'-dihydro-1'H-spiro[cyclopropane-1,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`134);
`
`6-(2;6-Dichlorophenyl)-2-((2';5'—dimethyl-2';3'-dihydro—1'H-spiro[cyclopropane-1,4'-
`
`isoquinolin]-7'—yl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`13 5);
`
`6-(2;6-Dichlorophenyl)—2-((3 ,5-dichloro-4-((3 S;5R)-3 ,4; 5-trimethylpiperazin-1-
`
`yl)phenyl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 13 6);
`
`6-(2;6-Dichlorophenyl)—2-((3 -chloro—5-methyl-4-((3 S;5R)-3 ,4; 5-trimethylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 13 7);
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`6-(2;6-Dichlorophenyl)—2-((4-(4-(dimethylamino)piperidin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 13 8);
`
`6-(2; 6-Dichlorophenyl)-2-((3 -chloro—4-(4-(dimethylamino)piperidin-1-yl)phenyl)amino)—8; 9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 13 9);
`
`6-(2; 6-Dichlorophenyl)-2-((3 -bromo—4-(4-(dimethylamino)piperidin-1-yl)phenyl)amino)—8; 9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 140);
`
`6-(2;6-Dichlorophenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)-3 -methylphenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 141);
`
`6-(2; 6-Dichlorophenyl)-2-((3 ; 5 -dichloro—4-(4-(dimethylamino)piperidin-1-yl)phenyl)amino)—
`
`8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 142);
`
`6-(2;6-Dichlorophenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)—3 -fluoro-5-
`
`methylphenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example
`
`143);
`
`6-(2;6-Dichlorophenyl)-2-((3 -chloro-4-(4-(dimethylamino)piperidin-1-yl)-5-
`
`methoxyphenyl)amino)—8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example
`
`144);
`
`6-(2; 6-Dichlorophenyl)-2-((3 -bromo—4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 145);
`
`6-(2; 6-Dichlorophenyl)-2-((3 -methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-8; 9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 146);
`
`6-(2;6-Dichlorophenyl)—2-((3 -chloro-5-fluoro—4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 147);
`
`6-(2;6-Dichlorophenyl)—2-((3 -fluoro—5-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 148);
`
`6-(2;6-Dichlorophenyl)-2-((3 -fluoro-5-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-
`
`8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 149);
`
`6-(2;6-Dichlorophenyl)—2-((3 ,5-dichloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 150);
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`6-(2;6-Dichlorophenyl)—2-((3 -chloro—5-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 151);
`
`6-(2;6-Dichlorophenyl)-2-((3 -chloro—4-(4-methylpiperazin-1-yl)—5-
`
`(trifluoromethyl)phenyl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one
`
`(Example 152);
`
`6-(2;6-Dichlorophenyl)—2-((3 -chloro-5-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)—
`
`8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 153);
`
`6-(2;6-Dichlorophenyl)—2-((3 -bromo—5-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 154);
`
`6-(2;6-Dichlorophenyl)—2-((3 -bromo-5-chloro—4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 155);
`
`6-(2;6-Dichlorophenyl)—2-((3 -bromo—5-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 156);
`
`6-(2;6-Dichlorophenyl)—2-((3 -bromo-5-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)—
`
`8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 157);
`
`6-(2;6-Dichlorophenyl)-2-((3 ; 5-dimethyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 158);
`
`6-(2;6-Dichlorophenyl)—2-((3 -methoxy-5-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-
`
`8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 159);
`
`6-(2-Bromo-6-chlorophenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)-3-fluoro—5-
`
`methylphenyl)amino)-8,9-dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example
`
`160);
`
`6-(2-B romo—6-chlorophenyl)-2-((3 -chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ 1 ;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 161);
`
`6-(2-B romo—6-chlorophenyl)-2-((3 -bromo-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 162);
`
`6-(2-B romo—6-chlorophenyl)-2-((3 -methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1;2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 163);
`
`Atty. Dkt. No. 33860100002
`
`
`
`- 14 -
`
`CAI el al.
`
`Application No. T0 be Assigned
`
`6-(2-Bromo—6-chlorophenyl)-2-((3 ,5-dichloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 164);
`
`6-(2-Bromo—6-chlorophenyl)-2-((3 -fluoro-5-methyl-4-(4-methylpiperazin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 165);
`
`6-(2-Bromo—6-chlorophenyl)-2-((3 -chloro-5-methyl-4-(4-methylpiperazin-1-
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 166);
`
`6-(2-Bromo—6-chlorophenyl)-2-((3 -bromo-5-methyl-4-(4-methylpiperazin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 167);
`
`6-(2-Fluoro-6-methylphenyl)-2-((3 -chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 168);
`
`6-(2-Fluoro-6-methylphenyl)—2-((3 ; 5 -dimethyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-8; 9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 169);
`
`6-(2-Chloro-6-methylphenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)-3-fluoro—5-
`
`methylphenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example
`
`170);
`
`6-(2-Chloro—6-methylphenyl)—2-((3 -chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[ 1 ,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 171);
`
`6-(2-Chloro-6-methylphenyl)-2-((3 ; 5-dichloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[l,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 172);
`
`6-(2-Chloro—6-methylphenyl)—2-((3 -chloro—5-methyl-4-(4-methylpiperazin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)—one (Example 173);
`
`6-(2-Chloro—6-methylphenyl)-2-((3 ;5-dimethyl-4-(4-methylpiperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 174);
`
`6-(2;6-Dichlorophenyl)—2-((4-(piperazin-1-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-
`
`a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 175);
`
`6-(2; 6-Dichlorophenyl)—2-((3 -chloro—4-(piperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 176);
`
`6-(2; 6-Dichlorophenyl)—2-((3 -methyl-4-(piperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5;4-e]pyrimidin-5(6H)-one (Example 177);
`
`Atty. Dkt. No. 33860100002
`
`
`
`- 15 -
`
`CAI el al.
`
`Application No. T0 be Assigned
`
`6-(2; 6-Dichlorophenyl)—2-((3 -methoxy-4-(piperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 178);
`
`6-(2-Chloro—6-fluorophenyl)-2-((3 -(hydroxymethyl)-4-(piperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 179);
`
`6-(2; 6-Dichlorophenyl)—2-((3 -(hydroxymethyl)-4-(piperazin-1-yl)phenyl)amino)—8; 9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 180);
`
`
`
`6-(2;6-Dichlorophenyl)—2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)—8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 182);
`
`6-(2;6-Dichlorophenyl)-2-((4-morpholinophenyl)amino)-8;9-dihydroimidazo[1,2-
`
`a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 183);
`
`6-(2;6-Dichlorophenyl)—2-((3 -((methylamino)methyl)-4-morpholinophenyl)amino)-8;9-
`
`dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one (Example 184);
`
`6-(2-B romo—6-chlorophenyl)-2-((3 -chloro—4-(4-(dimethylamino)piperidin- 1 -
`
`yl)phenyl)amino)-8;9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one (Example 185);
`
`6-(2; 6-Dichlorophenyl)—2-((3 -chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-8;9-
`
`dihydroimidazo[ 1 ,2-a]pyrimido[5,4-e]pyrimidin-5(6H)—one dihydrochloride (Example 186);
`
`and pharmaceutically acceptable salts or prodrugs thereof.
`
`Atty. Dkt. No. 3386.0100002
`
`
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