(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY(PCT)
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`(19) World Intellectual Property Organization
`International Bureau
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`ANUAADALAN
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`(10) International Publication Number
`(43) International Publication Date
`WO 2008/025791 Al
`6 March 2008 (06.03.2008)
`international Patent Classification:
`A61K 31/485 (2006.01)
`A6ILK 9/20 (2006.01)
`A6IP 25/04 (2006.01)
`A61K 9/70 (2006.01)
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`(SD
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`[US/US]; 25 Windrose Way, Greenwich, CT 06830 (US).
`WALDEN, Malcolm (GB/GB], c/o Mundipharma Re-
`search Limited, Cambridge Science Park, Milton Road,
`Cambridge CB4 OGW (GB).
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`(21)
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`International Application Number:
`PCT/EP2007/058978
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`(22)
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`International Filing Date: 29 August 2007 (29.08.2007)
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`(25)
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`Filing Language:
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`(26)
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`Publication Language:
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`English
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`English
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`(30)
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`Priority Data:
`06119839.6
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`30 August 2006 (30.08.2006)
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`EP
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`(7)
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`(72)
`(75)
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`Applicant (for all designated States except US): EURO-
`CELTIQUES.A. (LU/LU}; 122, Boulevard de la Pétrusse,
`L-2330 Luxembourg (LU).
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`Inventors; and
`Inventors/Applicants (for US only): OKSCHE, Alexan-
`der [DE/DE]; Birkenstr.
`22, 65550 Limburg (DE).
`HEATH,William (GB/GB]; c/o Napp Pharmaceuticals
`Limited, Cambridge Science Park, Milton Road, Cam-
`bridge, CB4 OGW (GB). HOLDEN,‘Timothy |GB/GB],
`c/o Napp Pharmaceuticals Limited, Cambridge Sci-
`ence Park, Milton Road, Cambridge, CB4 OGW (GB).
`PRATER, Derek A. (GB/GB]; c/o Mundipharma Re-
`search Limited, Cambridge Science Park, Milton Road,
`Cambridge, CB4 OGW (GB). SACKLER,Richard S.
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`(74)
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`(81)
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`Agent: BUEHLER, Dirk; Elisenhof, Elisenstrasse 3,
`80335 Miinchen (DE).
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`Designated States (unless otherwise indicated, for every
`kind of national protection available): AE, AG, AL, AM,
`AT, AU, AZ, BA, BB, BG, BH,BR, BW, BY, BZ, CA, CH,
`CN, CO, CR, CU, CZ, DE, DK, DM,DO, DZ, EC, EE, EG,
`ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU,ID,IL,
`IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK,
`LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, Mw,
`MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH,PL,
`PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV,SY,
`TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA,
`ZM, ZW.
`
`(84)
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`Designated States (unless otherwise indicated, for every
`kind of regional protection available): ARIPO (BW, GH,
`GM,KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM,
`ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM),
`European(AT, BE, BG, CH, CY, CZ, DE, DK, EE,ES, FI,
`FR, GB, GR,HU,IE,IS, IT, LT, LU, LV, MC, MT, NL, PL,
`PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM,
`GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
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`Published:
`with international search report
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`ee
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`(54) Title: BUPRENOPHINE-WAFER FOR DRUG SUBSTITUTION THERAPY
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`N (57) Abstract: The present inventionrelates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form
`releasing buprenorphineinstantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates
`to the use of such dosage formsfor treating pain in a human or animal or for drug substitution therapy in drug- dependent human
`subjects.
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`008/025791Ax.MLNIINNINANITIAUITTROUTTACT
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