`
`Sequence Listing was accepted.
`
`See attached Vaiidation Report.
`
`
`
`If you need help call the ?atent :1ectronic Rusiness Center at
`
`(866)
`
`
`
`
`217—9197 (toll free).
`
`Reviewer: Wheat Jr, Scott
`
`(ASRC)
`
`sec=46; ms=368;
`[year=2018; month=5; day=30; hr=l4; min=39;
`Timestamp:
`
`
`]
`
`
`
`Validated By CRFValidator v 1,0,5
`
`Application No:
`
`15988944
`
`Version No:
`
`LO
`
`Input Set:
`
`Output Set:
`
`Started:
`
`2018-05-24 18:17:42.734
`
`Finished:
`
`2018—05—24 18:17:48,220
`
`Elapsed:
`
`0 hr(s)
`
`0 min(s)
`
`5 sec(s)
`
`486 ms
`
`Total Warnings:
`
`Total Errors:
`
`No. of SquDs Defined:
`
`Actual SquD Count:
`
`97
`
`2
`
`70
`
`70
`
`Error code
`
`Error Description
`
`33
`
`33
`
`
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`201
`
`201
`
`2u3
`
`2H3
`
`2H3
`
`2u3
`
`2H3
`
`2H3
`
`2u3
`
`
`
`Mandatory f'e d data m'ss'ng
`in <l40>
`
`
`
`
`
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`Mandatory f'e d data m'ss'ng in <"4l>
`
`
`Ar: E'c a
`or on nown EOLnd 'n <7u3>
`fiQ
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`fiQ
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`fiQ
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`fiQ
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`fiQ
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`fiQ
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`
`E c'a or on nown EOLnd 'n <7u3>
`T-Q
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`Ar:
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`2H3
`
`2H3
`
`2u3
`
`2H3
`
`2H3
`
`2u3
`
`2H3
`
`2H3
`
`2u3
`
`2H3
`
`2H3
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`W
`
`
`
`Input Set:
`
`Output Set:
`
`Started:
`
`2018—05—24 18:17:42,734
`
`Finished:
`
`2018—05—24 18:17:48,220
`
`Elapsed:
`
`0 hr(s)
`
`0 min(s)
`
`5 sec(s)
`
`486
`
`ms
`
`Total Warnings:
`
`Total Errors:
`
`No. of SquDs Defined:
`
`Actual SquD Count:
`
`97
`
`2
`
`70
`
`70
`
`Errorcode
`
`Error Description
`
`W
`
`W
`
`213
`
`213
`
`W M7
`
`W M7
`
`
`
`Art f c'a or Unknown found 'n <2l3>
`S?
`
`
`
`
`
`
`
`
`
`
`'n S?
`
`Art f c'a or Unknown found 'n <2l3>
`
`Thls error has occured more than 20 :lmes,
`
`'1e 1Ln
`
`1 or Xaa Lsed,
`
`for:
`
`SEQID(24)
`
`0
`
`Q ID
`
`(19)
`
`Q ID
`wil.
`
`(20)
`_ not be displayed
`
`ber
`
`"234
`
`1 or Xaa Lsed,
`
`for:
`
`SEQID(24)
`
`0
`
`
`'1e 1Ln
`
`ber
`
`"238
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(24)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(25)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(25)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(25)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(26)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(26)
`
`SEQID(26)
`
`
`'1e 1Ln
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`ber
`
`"242
`
`ber
`
`"328
`
`ber
`
`"332
`
`ber
`
`"336
`
`ber
`
`"407
`
`ber
`
`"411
`
`ber
`
`"415
`
`0
`
`0
`
`0
`
`0
`
`0
`
`0
`
`0
`
`
`
`W M7
`
`W M7
`
`W M7
`
`
`
`
`
`
`
`for
`
`for
`
`for
`
`for
`
`
`
`SEQID(28)
`
`SEQID(28)
`
`SEQID(28)
`
`SEQID(28)
`
`
`
`0
`
`0
`
`0
`
`0
`
`0
`
`
`
`1 or Xaa Lsed,
`
`1 or Xaa Lsed,
`
`1 or Xaa Lsed,
`
`1 or Xaa Lsed,
`
`W M7
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(28)
`
`
`'1e 1Ln
`
`ber
`
`"711
`
`
`
`
`
`
`
`
`
`
`
`
`"695
`
`"699
`
`"707
`
`
`
`ber
`
`ber
`
`ber
`
`
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`W M7
`
`1 or Xaa Lsed,
`
`for
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(27)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(27)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(27)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(28)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(28)
`
`1 or Xaa Lsed,
`
`for
`
`SEQID(28)
`
`0
`
`0
`
`0
`
`0
`
`0
`
`0
`
`
`'1e 1Ln
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`'1e 1Ln
`
`
`'1e 1Ln
`
`ber
`
`"476
`
`ber
`
`"480
`
`ber
`
`"484
`
`ber
`
`"675
`
`ber
`
`"679
`
`ber
`
`"683
`
`ber
`
`"691
`
`
`
`Input Set:
`
`Output Set:
`
`Started:
`
`2018—05—24 18:17:42,734
`
`Finished:
`
`2018—05—24 18:17:48,220
`
`Elapsed:
`
`0 hr(s)
`
`0 min(s)
`
`5 sec(s) 486 ms
`
`Total Warnings:
`
`Total Errors:
`
`No. of SquDs Defined:
`
`Actual SquD Count:
`
`97
`
`2
`
`70
`
`70
`
`Error code
`
`Error Description
`
`W
`
`402
`
`Undefined organism found in <213>
`
`
`in SEQ ID (62)
`
`
`
`
`
`
`"10> JANUX 1H4RAP4UTICS,
`
`A
`
`INC.
`
`
`
`
`
` O]
`QU‘NC* LISLING
`
`
`.l
`
`
`<120> MODIEILD ANiIBODIsS
`
` <170> PatentIn version 3.5
`
`<"30> 52426—701.201
`
`A a O V
`<"41>
`
`US 15/988,944
`2018—05—24
`
`/\
`
`"50> 62/511,771
`<"51> 2017—05—26
`
`A "60> 7O
`
`<210> 1
`<211> 40
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`<220>
`
`
`
`
`<221> MIsc_r«AiUR«
`<222> (l)..(40)
`
`'GS' repeating units
`<223> This sequence may encompass 6—20
`wherein some positions may be absent
`
`<400> 1
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`1
`5
`10
`15
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`20
`25
`30
`
`Gly Ser Gly Ser Gly Ser Gly Ser
`35
`40
`
`<210> 2
`<211> 39
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`<220>
`
`
`
`
`<221> MISC_t*AlUR*
`<222> (1)..(39)
`
`'GGS' repeating
`<223> This sequence may encompass 4—13
`units wherein some positions may be absent
`
`<400> 2
`
`Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
`l
`5
`10
`15
`
`Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
`20
`25
`30
`
`Ser Gly Gly Ser Gly Gly Ser
`35
`
`<210> 3
`<211> 4O
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`<220>
`
`
`
`
`<221> MISCit*AiUR~
`<222> (1)_.(40)
`
`'GGGS' repeating
`<223> This sequence may encompass 3—10
`units wherein some positions may be absent
`
`<400> 3
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
`1
`5
`10
`15
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
`20
`25
`30
`
`Gly Gly Gly Ser Gly Gly Gly Ser
`35
`40
`
`<210> 4
`<211> 40
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`<220>
`
`
`
`
`<221> MISC_h«AlUR«
`<222> (l)..(40)
`
`'GGGGS'
`<223> This sequence may encompass 2—8
`repeating units wherein some positions may be absent
`
`<400> 4
`
`Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
`l
`5
`10
`15
`
`Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
`20
`25
`30
`
`Gly Gly Ser Gly Gly Gly Gly Ser
`35
`40
`
`<210> 5
`<211> 4O
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`<220>
`
`
`
`
`<221> MISC_t*AJ.UR*
`<222> (l)..(40)
`'G' repeating
`<223> This sequence may encompass 12—40
`units wherein some positions may be absent
`
`<400> 5
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`l
`5
`10
`15
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`20
`25
`30
`
`Gly Gly Gly Gly Gly Gly Gly Gly
`35
`40
`
`<210> 6
`<le> 33
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`<220>
`
`
`
`
`<221> MISCit*AlUR‘
`<222> (1)..(33)
`
`'GGGSGSGGGGS' repeating
`<223> This sequence may encompass 1—3
`units wherein some positions may be absent
`
`<400> 6
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly
`1
`5
`10
`15
`
`Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly
`20
`25
`30
`
`Ser
`
`<210> 7
`<211> 33
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`<220>
`
`
`
`
`<221> MISC_h<AlUR«
`<222> (1)..(33)
`
`'GGGGGPGGGGP' repeating
`<223> This sequence may encompass 1—3
`units wherein some positions may be absent
`
`<400> 7
`
`Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly
`1
`5
`10
`15
`
`Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly
`20
`25
`30
`
`Pro
`
`<210> 8
`<211> 36
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`
`
`
`polypeptide
`
`<220>
`
`
`
`
`<221> MISC_t*AlUR*
`<222> (l)..(36)
`'GGSGGD' repeating
`<223> This sequence may encompass 2—6
`units wherein some positions may be absent
`
`<400> 8
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly
`l
`5
`10
`15
`
`Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`20
`25
`30
`
`Ser Gly Gly Asp
`35
`
`<210> 9
`<le> 36
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`<220>
`
`
`
`
`<221> MISCit*AlUR~
`<222> (1)_.(36)
`
`
`'GGSGGE' repeating
`<223> This sequence may encompass 2—6
`units wherein some positions may be absent
`
`<400> 9
`
`Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly
`l
`5
`10
`15
`
`Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly
`20
`25
`30
`
`Ser Gly Gly Glu
`35
`
`<210> 10
`<211> 116
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`
`
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_h*A1UR*
`(1)..(40)
`
`'GS' repeating
`This region may encompass 0—20
`units wherein some positions may be absent
`
`
`
`
`MISC_h*A1UR*
`(41)..(76)
`
`'GGSGGD' repeating
`This region may encompass 2—6
`units wherein some positions may be absent
`
`
`
`
`MISC_b*A1UR*
`(77)..(116)
`
`'GS' repeating
`This region may encompass 0—20
`units wherein some positions may be absent
`
`<400>
`
`10
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`1
`
`Gly
`15
`
`Ser
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`20
`25
`30
`
`Gly
`
`Ser
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Gly Asp
`35
`40
`45
`
`Gly
`
`Ser Gly Gly Asp Gly Gly
`
`m (D H O H ‘< O H k<1 W m 6 O H k<1 Gly Ser Gly
`(II (II
`60
`
`Gly
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Ser
`65
`70
`75
`
`Gly
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`85
`9O
`
`Gly
`95
`
`Ser
`80
`
`Ser
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`100
`105
`110
`
`Ser
`
`Gly
`
`Gly Ser Gly Ser
`115
`
`<2lO>
`<211>
`
`11
`114
`
`
`
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISCit~AiUR*
`(1)—-(39)
`
`'GGS' repeating
`This region may encompass 0—13
`units wherein some positions may be absent
`
`
`
`
`MISCit~AiUR*
`(40).-(75)
`
`'GGSGGD' repeating
`This region may encompass 2—6
`units wherein some positions may be absent
`
`
`
`
`MISCit*AiUR~
`(76)..(114)
`
`'GGS' repeating
`This region may encompass 0—13
`units wherein some positions may be absent
`
`<400>
`
`ll
`
`Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
`1
`
`Ser
`15
`
`Gly
`
`Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser
`20
`25
`30
`
`Gly
`
`Ser Gly
`
`O H K Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Gly
`U.) (fl
`40
`45
`
`Ser
`
`Gly
`
`Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly
`50
`55
`6O
`
`Asp
`
`Gly
`
`Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser
`65
`7O
`75
`
`Gly
`
`Gly
`80
`
`Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
`
`Ser
`
`Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
`100
`105
`110
`
`Ser
`
`Gly
`
`Gly Ser
`
`
`
`<210>
`<21l>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`12
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_t*AlUR*
`
`(1)..(40)
`
`'GGGS' repeating
`This region may encompass 0—10
`units wherein some positions may be absent
`
`
`
`
`MISC_t*AlUR*
`
`(41)..(76)
`'GGSGGD' repeating
`This region may encompass 2—6
`units wherein some positions may be absent
`
`
`
`
`MISC_t*AlUR*
`
`(77)..(116)
`
`'GGGS' repeating
`This region may encompass 0—10
`units wherein some positions may be absent
`
`<400>
`
`12
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`1
`
`Gly
`15
`
`Ser
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`20
`25
`3O
`
`Ser
`
`Gly
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Asp
`35
`40
`45
`
`Gly
`
`Gly
`
`Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly
`50
`55
`6O
`
`Gly
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`
`Gly
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`85
`9O
`
`Gly
`95
`
`Ser
`80
`
`Ser
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`100
`105
`110
`
`Ser
`
`Gly
`
`
`
`Gly Gly Gly Ser
`115
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`13
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_h*A1UR*
`(1)..(40)
`
`'GGGGS' repeating
`This region may encompass 0—8
`units wherein some positions may be absent
`
`
`
`
`MISC_h*A1UR*
`(41)..(76)
`
`'GGSGGD' repeating
`This region may encompass 2—6
`units wherein some positions may be absent
`
`
`
`
`MISC_b*A1UR*
`(77)..(116)
`
`'GGGGS' repeating
`This region may encompass 0—8
`units wherein some positions may be absent
`
`<400>
`
`13
`
`Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
`1
`(fl
`10
`
`Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
`20
`25
`3O
`
`Gly
`
`Gly
`
`Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Asp
`35
`40
`45
`
`Gly
`
`Ser Gly Gly Asp Gly Gly
`
`m (D H O H ‘< O H k<1 W m 6 Gly Gly Ser Gly
`(II (II
`60
`
`Gly
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`65
`70
`75
`
`Gly
`
`Gly
`80
`
`Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
`85
`9O
`
`Gly
`95
`
`Ser
`
`
`
`Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
`100
`105
`110
`
`Gly Gly Gly Ser
`115
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`14
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC7t*AiUR~
`(1).. (40)
`
`'G' repeating
`This region may encompass 0—40
`units wherein some positions may be absent
`
`
`
`
`MISCit*A1UR‘
`- (76)
`(41) -
`
`'GGSGGD' repeating
`This region may encompass 2—6
`units wherein some positions may be absent
`
`
`
`
`MISCiJrAiUR~
`(77) .
`. (116)
`
`'G' repeating
`This region may encompass 0—40
`units wherein some positions may be absent
`
`<400>
`
`14
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`1
`
`Gly
`15
`
`Gly
`
`20
`
`25
`
`Gly
`
`3O
`
`O H K O H K O H K O H K O H K O H K O H K
`U.) (fl
`
`Gly Gly Gly Ser Gly Gly Asp
`40
`45
`
`Gly
`
`Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly
`50
`55
`6O
`
`Gly
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`65
`7O
`75
`
`Gly
`
`Gly
`80
`
`
`
`Gly Gly Gly
`
`Gly
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`85
`9O
`95
`
`Gly Gly Gly
`
`Gly
`100
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`105
`110
`
`Gly Gly Gly
`115
`
`<210> 15
`<211> 102
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence:
`polypeptide
`
`Synthetic
`
` <220>
`
`
`<221> MISC_t*AlUR*
`<222> (1)..(33)
`
`<223> This region may encompass 0—3
`units wherein some positions may be absent
`
`'GGGSGSGGGGS'
`
`repeating
`
`<220>
` ‘AlUR‘
`<221> MISC_t
`<222> (34)..(69)
`<223> This region may encompass 2—6
`repeating
`units wherein some positions may be absent
`
`'GGSGGD'
`
`<220>
`<221> MISC_t ‘AlUR‘
`<222> (70)..(102)
`
`<223> This region may encompass 0—3
`units wherein some positions may be absent
`
`'GGGSGSGGGGS'
`
`repeating
`
`<400> 15
`
`Gly Gly Gly
`1
`
`Ser
`
`Gly
`
`Ser
`
`Gly
`
`Gly
`
`Ser
`
`Gly
`10
`
`Ser Gly Gly
`
`Gly
`20
`
`Ser
`
`Gly
`
`Ser
`
`Ser
`
`Ser
`
`15
`
`Gly
`
`Ser Gly Gly
`35
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`40
`
`Gly
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`
`Gly Ser
`
`Gly Gly Asp
`50
`
`Ser Gly
`55
`
`Gly
`
`Ser
`
`60
`
`
`
`Gly Ser Gly
`65
`
`Gly
`
`Asp
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser
`70
`75
`80
`
`Gly Gly Gly
`
`Ser
`
`Gly
`85
`
`Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly
`90
`95
`
`Ser Gly Gly
`
`Gly
`100
`
`Ser
`
`<210> l6
`<211> 102
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence:
`polypeptide
`
`Synthetic
`
` <220>
`
`
`<221> MISC_t*AlUR*
`<222> (l)..(33)
`
`<223> This region may encompass 0—3
`units wherein some positions may be absent
`
`'GGGSGSGGGGP'
`
`repeating
`
`<220>
`
`
`
`
`<221> MISC_t*AlUR*
`<222> (34)..(69)
`<223> This region may encompass 2—6
`repeating
`units wherein some positions may be absent
`
`'GGSGGD'
`
`<220>
`
`
`
`
`<221> MISC_t*AlUR*
`<222> (70)..(102)
`
`<223> This region may encompass 0—3
`units wherein some positions may be absent
`
`'GGGSGSGGGGP'
`
`repeating
`
`<400> 16
`
`Gly Gly Gly
`1
`
`Ser
`
`Gly
`
`Ser
`
`Gly
`
`Gly
`
`Pro
`
`Gly
`10
`
`Ser Gly Gly
`
`Gly
`20
`
`Pro
`
`Gly
`
`Ser
`
`Ser
`
`Ser
`
`15
`
`Gly
`
`Pro Gly Gly
`35
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`40
`
`Gly
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`
`Gly Ser
`
`Gly Gly Asp
`50
`
`Ser Gly
`55
`
`Gly
`
`Ser
`
`60
`
`
`
`Gly Ser Gly Gly Asp Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Pro
`65
`7O
`75
`80
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Pro Gly Gly Gly Ser Gly
`85
`9O
`95
`
`Ser Gly Gly Gly Gly Pro
`100
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`17
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_t*AlUR*
`
`(l)..(40)
`
`'GS' repeating
`This region may encompass 0—20
`units wherein some positions may be absent
`
`
`
`
`MISC_t*AlUR*
`
`(41)..(76)
`'GGSGGE' repeating
`This region may encompass 2—6
`units wherein some positions may be absent
`
`
`
`
`MISC_t*AlUR*
`
`(77)..(ll6)
`
`'GS' repeating
`This region may encompass 0—20
`units wherein some positions may be absent
`
`<400>
`
`17
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`1
`5
`
`
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