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`_-001—US-20150073258 03-12-2015
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`Receipt: date: 06/05/2018
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`15/987,7R4 .. GAE}: 3737
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`N
`
`2016 Alzheimer's disease facts and figures. Alzheimers Dement 12(4):459-509 (2016).
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`BAKKER et al. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance
`for Neurodegenerative Diseases. Cell Mol Neurobiol 36(2):181-194 (2016).
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`BARNETT et al. Early intervention in Alzheimer's disease: a health economic study ofthe
`effects ofdiagnostic timing. BMC Neurology 14:101 (2014).
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`CASH et al. The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from
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`CAVEDO et al. The Road Ahead to Cure Alzheimer's Disease: Development of Biological
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`GAUTHIER et al. Mild cognitive impairment. Lancet 367(9518):1262-70 (2006).
`
`E
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`'
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`[DON N HC/
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`Dt
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`08/08/2018
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`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
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`Receipt: date: 06/05/2018
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`152/987,?94 w GM}: 3737
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`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`Substitute for form 1449/PTO
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`Complete if Known
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`—15987794
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`STATEMENT BY APPL'CANT
`(Use as many sheets as necessary)
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`INFORMATION DISCLOSURE —Eifflj\ff;iRE PADIDEH
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`Include name ofthe author(in CAPITAL LETTERS),titIe of the article(when appropriate), title of
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`number(s),publisher, city and/or country where published.
`
`GREENE et al. Subregions of the inferior parietal lobule are affected in the progression to
`Alzheimer's disease. Neurobiol Aging 31(8):1304-1311 (2010).
`
`HAMPEL et al. Core candidate neurochemical and imaging biomarkers of Alzheimer's disease.
`Alzheimers Dement 2008. 4(1):38-48.
`
`HEBERT et al. Alzheimer disease in the United States (2010-2050) estimated using the 2010
`census. Neurology 80(19):1778-1783 (2013).
`
`HEBERT et al. Annual incidence of Alzheimer disease in the United States projected to the
`years 2000 through 2050. Alzheimer Dis Assoc Disord 15:169-173 (2001).
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`HRABETOVA et al. Dead-space microdomains hinder extracellular diffusion in rat neocortex
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`HUANG et al. Longitudinal measurement and hierarchical classification framework forthe
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`JENKINS et al. Developmental and age-related changes in rat brain glycosaminoglycans. J
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`E
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`'
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`Dt
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`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
`Translation is attached. This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
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`/D..NH[
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`

`

`Receipt: date: 06/05/2018
`
`15/987,7R4 .. GAE}: 3737
`
`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`Substitute for form 1449/PTO
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`Complete if Known
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`—15987794
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`INFORMATION DISCLOSURE
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`STATEMENT By APPLICANT
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`Include name ofthe author(in CAPITAL LETTERS),titIe of the article(when appropriate), title of
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`number(s),publisher, city and/or country where published.
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`N
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`
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`Initials*
`
`LIEBMANN et al. Three-Dimensional Study of Alzheimer‘s Disease Hallmarks Using the iDlSCO
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`MAYO et al. Longitudinal changes in microstructural white matter metrics in Alzheimer's
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`Impairment and Alzheimer's disease: a systematic review. BMC Geriatr16:104 (2016).
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`E
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`'
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`Dt
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`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
`Translation is attached. This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1-800-786-9199} and select option 2.
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`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH.
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`/D..NH[
`
`

`

`Receipt: date: 06/05/2018
`
`15/987,7R4 .. GAE}: 3737
`
`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`Substitute for form 1449/PTO
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`Complete if Known
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`—15987794
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`INFORMATION DISCLOSURE
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`STATEMENT By APPLICANT
`(Use as many sheets as necessary) —3737
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`NON-PATENT LITERATURE DOCUMENTS
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`Examiner
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`Include name ofthe author(in CAPITAL LETTERS),titIe of the artic|e(when appropriate), title of
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`number(s),publisher, city and/or country where published.
`
`N
`
`SCHMAND et al. Meta-analysis of CSF and MRI biomarkers for detecting preclinical
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`
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`WEINER et al. 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of
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`XIE et al. Sleep drives metabolite clearance from the adult brain. Science 342(6156):373-377
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`
`YOSHIYAMA et al. Synapse loss and microglial activation precede tangles in a P301S
`tauopathy mouse model. Neuron 53(3):337-351 (2007).
`
`E
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`mom N HO/
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`Dt
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`08/08/2018
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`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
`Translation is attached. This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1-800-786-9199} and select option 2.
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`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH.
`
`/D..NH[
`
`

`

`Receipt: date: 06/05/2018
`
`15/987,794 w GM}: 3737
`
`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`Substitute for form 1449/PTO
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`Complete if Known
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`—15987794
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`STATEMENT BY APPL'CANT
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`INFORMATION DISCLOSURE —Eifflj\ff;iRE PADIDEH
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`and osmosis with extracellular space geometry. Phys Rev E 94(3-1):032411 (2016).
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`Examiner
`|nitia|s*
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`.
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`NON-PATENT LITERATURE DOCUMENTS
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`Include name ofthe author(in CAPITAL LETTERS),titIe of the artic|e(when appropriate), title of
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`number(s),publisher, city and/or country where published.
`
`YOUSEFNEZHAD et al. Unified model of brain tissue microstructure dynamically binds diffusion
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`*EXAMINER: lnitial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. lnclude
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
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`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
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`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH.
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`/D..NH[
`
`