_ 18 _
`
`CLAIMS
`
`What is claimed is:
`
`A cryovial storage system comprising:
`
`a hexagonal box configured for receiVing cryovials; the box comprising:
`
`an open top end;
`
`a bottom end;
`
`six intersecting sides positioned there between; and
`
`a frame with a central axis parallel to the sides; the frame comprising:
`
`a rod hole centered on the central axis and configured to receive a rod; and
`
`an array of Vial holes configured to hold cryovials arrayed around the central
`
`axis in one or more concentric rings; each concentric ring from innermost to outermost
`
`comprising increasing numbers of holes starting at six; and increasing by six in each
`
`concentric ring.
`
`A cryovial storage system comprising:
`
`a hexagonal box configured for receiVing cryovials; the box comprising:
`
`an open top end;
`
`a bottom end;
`
`six intersecting sides positioned there between; and
`
`a frame with a central axis parallel to the sides; the frame comprising:
`
`a rod hole centered on the central axis and configured to receive a rod; and
`
`an array of Vial holes configured to hold cryovials arrayed around the central
`
`axis in one or more concentric rings; each concentric ring from innermost to outermost
`
`comprising increasing numbers of holes wherein the frame comprises 11 concentric rings and
`
`3*n*(n+l) holes.
`
`The cryovial storage system of claim 1 or 2 wherein the frame comprises a first ring of six
`
`holes.
`
`Atty. Dkt. No. 2602.0190001
`
`

`

`The cryovial storage system of claim 3 wherein the frame comprises a second ring distal
`
`from the central axis; the second ring comprising 12 holes.
`
`-19-
`
`The cryovial storage system of claim 4 wherein the frame comprises a third ring distal from
`
`the central axis; the third ring comprising 18 holes.
`
`The cryovial storage system of claim 1 additionally comprising:
`
`a canister with an open top end;
`
`a bottom end;
`
`a sidewall positioned there between; and
`
`a central axis equidistant from the canister wall;
`
`wherein the canister wall has a circular or hexagonal cross section;
`
`wherein the canister is configured to contain the hexagonal box; the hexagonal box
`
`configured to removably fit within the canister; such that the sides of the hexagonal box are
`
`parallel to and in proximity to the sidewall of the canister.
`
`The cryovial storage system of claim 6 comprising a stacked multiplicity of hexagonal boxes.
`
`The cryovial storage system of claim 6 wherein the cross section of the canister is circular.
`
`The cryovial storage system of claim 6 wherein the cross section of the canister is hexagonal.
`
`10.
`
`The cryovial storage system of claim 7 additionally comprising:
`
`a canister insert; the insert comprising a base with a center;
`
`wherein the insert is configured to fit within the canister parallel to the bottom of the
`
`canister;
`
`wherein the center of the base is affixed to the rod; and
`
`wherein the rod extends perpendicularly upward from the base along the central axis
`
`of the canister.
`
`Atty. Dkt. No. 2602.0190001
`
`

`

`11.
`
`12.
`
`13.
`
`14.
`
`The cryovial storage system of claim 10 wherein the hexagonal boxes are configured to be
`
`stacked upon the base such that the rod passes through the rod holes of the hexagonal box.
`
`_ 20 _
`
`The cryovial storage system of claim 11 wherein the canister is hexagonal.
`
`The cryovial storage system of claim 12 wherein the open top end of the canister is
`
`castellated with six regularly spaced notches, each within a side of the canister, and each
`
`notch is configured to receive an intersecting corner of the hexagonal box when the
`
`hexagonal box is placed within the notches.
`
`A method of accessing vials from the hexagonal box of claim 12 comprising:
`
`a.
`
`raising the rod vertically thereby lifting the stack of hexagonal boxes such that
`
`the bottom of the topmost hexagonal box in the stack is above the open top end of the
`
`canister;
`
`b.
`
`rotating the topmost hexagonal box around the rod such that each pair of
`
`intersecting sides of the topmost box rests upon an edge of the canister;
`
`c.
`
`d.
`
`lowering the rod back into the canister; and
`
`removing cryovials from the topmost hexagonal box.
`
`15.
`
`The method of claim 13 comprising a castellated open top end of the canister; with six
`
`regularly spaced notches; each within a side of the canister; and each notch adapted to
`
`receive the comer of intersecting sides of the hexagonal box.
`
`16.
`
`A cryovial storage system comprising:
`
`a hexagonal box; the hexagonal box comprising:
`
`six sidewalls;
`
`a base coupled to the sidewalls; and
`
`a frame coupled to the base and sidewalls;
`
`wherein the frame defines a plurality of vial holes configured for holding
`
`cryovials; and wherein the frame further defines a central channel.
`
`Atty. Dkt. No. 2602.0190001
`
`

`

`-21-
`
`17.
`
`The cryovial storage system according to claim 16, further comprising:
`
`a canister, the canister comprising:
`
`a sidewall having an inner surface and an outer surface;
`
`a base coupled to the sidewall; and
`
`an interior void defined by the sidewall inner surface and the base,
`
`wherein the interior void is configured such that the hexagonal box can be
`
`placed within the interior void.
`
`18.
`
`19.
`
`20.
`
`21.
`
`22.
`
`The cryovial storage system according to claim 17, wherein the base further comprises an
`
`upwardly projecting rod extending vertically through the void, and wherein the central
`
`channels of the frames of the hexagonal boxes are configured for slideably receiving the rod
`
`when the hexagonal boxes are placed within the interior void.
`
`The cryovial storage system according to claim 18, wherein the canister comprises a
`
`hexagonal cross-sectional structure, and wherein the canister comprises six discrete
`
`sidewalls.
`
`The cryovial storage system according to claim 19, wherein the six sidewalls extend upward
`
`to form a topmost edge, and wherein the six sidewalls include a plurality of castellations, one
`
`per sidewall, among them projecting downward from the topmost edge of each sidewall.
`
`The cryovial storage system according to claim 20, wherein each of the six sidewalls
`
`includes a single one of the plurality of castellations.
`
`The cryovial storage system according to claim 21, wherein each one of the plurality of
`
`castellations is rectangular, centered in the sidewall of the canister and measuring 1/3 of the
`
`width of one side of the hexagonal box with a vertical dimension equivalent to the height of
`
`one hexagonal box or a portion of the height thereof.
`
`Atty. Dkt. No. 2602.0190001
`
`

`

`_ 22 _
`
`23.
`
`The cryovial storage system according to claim 22, wherein the hexagonal box is a first
`
`hexagonal box, the cryovial storage system further comprising:
`
`a second hexagon box configured similarly to the first hexagonal box,
`
`wherein the first and second hexagonal boxes are configured to be stacked on top of
`
`one another and for slideably receiving the rod through their central channels.
`
`24.
`
`25.
`
`26.
`
`27.
`
`28.
`
`The cryovial storage system according to claim 23, wherein the first hexagonal box is
`
`configured to be stacked on top of the second hexagonal box in a first configuration where
`
`faces of the six sidewalls of each of the first and second hexagonal boxes are aligned with
`
`one another.
`
`The cryovial storage system according to claim 24, wherein the first hexagonal box is
`
`configured to rest upon the castellations of the canister above the second hexagonal box in a
`
`second configuration where the faces of the six sidewalls of each of the first and second
`
`hexagonal boxes are offset from one another.
`
`The cryovial storage system according to claim 25, wherein the first hexagonal box is moved
`
`from the first configuration to the second configuration by elevating the rod and then rotating
`
`first hexagonal box about the rod before being placed to rest upon the castellations of the
`
`canister.
`
`The cryovial storage system according to claim 17, wherein the canister is substantially
`
`cylindrical having a circular cross-section, wherein the interior void comprises a substantially
`
`cylindrical volume, and wherein the plurality of vial holes are circles having a consistent
`
`diameter D.
`
`The cryovial storage system according to claim 27, wherein the number of vial holes having
`
`a diameter D that can be accommodated by the frame of the hexagonal box that can be placed
`
`into the void of the canister is greater than the number of vial holes having the same diameter
`
`Atty. Dkt. No. 2602.0190001
`
`

`

`D that could be accommodated by a frame of a rectangular box that could be placed into the
`
`void of the canister.
`
`_ 23 _
`
`29.
`
`The cryovial storage system according to claim 27, wherein the frames of the hexagonal
`
`boxes that can be placed into the void of the canisters in the payload compartment of the dry
`
`shipper or cryobank can accommodate a greater density of vial holes having diameter D than
`
`the density of vial holes having diameter D that could be accommodated by the frames of
`
`rectangular boxes that could be placed into the void of the dry shipper or cryobank.
`
`Atty. Dkt. No. 2602.0190001
`
`

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