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`A 7697-709201
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`INFORMATION DISCLOSURE
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`BALASUBRAMAN IAN Shankar et al
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`PINTER; Jonathon H. et al.
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`Approved for use through 11/30/2020. OMB 0651-0031
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`15/952,203 _. GAU: 1637
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`Substitute for form 1449/PTO
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`n1
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`~
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` OLIPHANT; Arnold et al.
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`INFORMATION DISCLOSURE —g:;3V2V‘§/3MP Tmoth A
`STATEMENT BY APPLICANT
`MU”,
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`US-20060024678
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`BUZBY Phlllp R
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`LAPIDUS Stanley N et al
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`04 13-2006
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`SRINIVASAN; Malthreyan et al
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`US-20100068711
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`03 18 2010
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`UMANSKY; Samuil R. et al
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`US-20120021412
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`01 26 2012
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`MELKONYAN; Hovsep et al.
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`03-29 2012
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`[TERESA E STRZELECKA/
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`11/15/2919
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`lnclude copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
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`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
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`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this
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`Approved for use through 11/30/2020. OMB 0651-0031
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`15/952,293 _. GAU: 1637
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`INFORMATION DISCLOSURE
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`Complete if Known
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`Substitute for form 1449/PTO
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`Attorney Docket Number
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`U. S. PATENT DOCUMENTS
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`US-20170166982
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`06-15-2017
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`THIERRY; Alain et al.
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`FOREIGN PATENT DOCUMENTS
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`Country Codea’NumberATKind Code5 (if known)
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`11'21'2007
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`02'13'2008
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`Name of Patentee or
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`Pages, Columns, Lines,
`Where Relevant Passages
`Or Relevant Figures Appear
`
`ISTITUTO NAZ PER
`LE MALATTIE I [IT]
`
`ISTITUTO NAZ PER
`LE MALATTIE I [IT]
`
`TROVAGENE INC
`
`[US]
`
`Examiner
`
`,I’TERESA E STRZELECKA/
`
`Date
`
`11/15/2019
`
`1
`2
`*EXAMINER: lnitial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
`4
`considered.
`lnclude copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
`5
`Documents at wwwusgtogov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). For Japanese patent documents, the
`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
`document under WlPO Standard ST.16 if possible. 6Applicant is to place a check mark here if English language Translation is attached. This collection of information is required by
`37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application. Confidentiality is
`governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the completed application
`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this
`burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED
`FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
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`/T . E ., S/
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`Approved for use through 11/30/2020. OMB 0651-0031
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`INFORMATION DISCLOSURE
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`03
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`FOREIGN PATENT DOCUMENTS
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`WO-2012159023-A2
`
`11-22-2012
`
`WO-2012168815-A2
`
`12-13-2012
`
`UNIV VIRGINIA
`COMMONWEALTH
`
`[US], et al.
`KONINKL PHILIPS
`ELECTRONICS NV
`
`[NL], et al.
`
`WO-2013052907-A2
`
`04-11-2013
`
`[SUESQ]UENOM'NC
`
`WO-2013132305-A1
`
`WO-2013156627-A1
`
`WO-2013159035-A2
`
`UMVHONGKONG
`09-12-2013 CHINESHCN]
`
`10-24-2013
`
`PASTEUR
`INSTITUUFR]
`
`WISCONSIN MED
`10-24-2013 COLLEGE NC [US]
`
`WO-2013188846-A1
`
`12-19-2013
`
`STYHJHARRY
`
`[US]
`
`GUARDANT
`
`WO-2014039556-A1
`
`03-13-2014 HEALTH INC [US],
`et al.
`
`WO-2014068075-A1
`
`05-08-2014
`
`WO-2014149134-A2
`
`09-25-2014
`
`GENESUPPORT
`
`SA [CH]
`
`GUARDANT
`
`
`
`HEALTH INC [US]
`
`Examiner
`
`Date
`
`[TERESA E STRZELECKA/
`
`11/15/2019
`
`1
`2
`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
`4
`considered. Include copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
`5
`Documents at wwwusgtogov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). For Japanese patent documents, the
`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
`document under WIPO Standard ST.16 if possible. 6Applicant is to place a check mark here if English language Translation is attached. This collection of information is required by
`37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application. Confidentiality is
`governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the completed application
`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this
`burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED
`FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
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`fT . E . S/
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`Approved for use through 11/30/2020. OMB 0651-0031
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`
`15/952,293 _. GAU: 1637
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`Substitute for form 1449/PTO
`_
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`Complete if Known
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`Application Number
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`15952203
`
`.
`
`—§:X3v2v?<1/3Mp Tmoth A
`MU,“
`1574
`y
`ot Yet Assigned
`Attorney Docket Number
`A 7697-709201
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`;
`
`I
`
`.N
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Use as many sheets as necessary)
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`NON-PATENT LITERATURE DOCUMENTS
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`Initials*
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`
`Include name ofthe author(in CAPITAL LETTERS),titIe of the article(when appropriate), title of
`the item (book,magazine,journal,serial,symposium,cata|og,etc.),date,page(s),vo|ume-issue
`number(s),publisher, city and/or country where published.
`
`N
`
`CONSTANS, A. Beyond Sanger: Toward the $1,000 Genome.The Scientist. 30 June 2003;
`17(13): 36.
`
`DRMANAC, R. et al. Human genome sequencing using unchained base reads on self-
`assembling DNA nanoarrays. Science 327, 78-81 (20 1 0).
`
`GANSAUGE, et al. Single-stranded DNA library preparation forthe sequencing of ancient or
`damaged DNA. Nat Protoc. 2013 Apr;8(4):737-48. doi: 10.1038/nprot.2013.038. Epub 2013 Mar
`14.
`
`GARAJ, et al. Graphene as a sub-nanometertrans-electrode membrane. Nature. 2010
`September 9, 467.7312: 190-193. doi: 10.1038/nature09379.
`
`HIGHLANDER, Sarah K., High throughput sequencing methods for microbiome profiling:
`application to food animal systems, Animal Health Research Reviews, June 2012, Volume
`13(1); pages 40-53.
`
`HUBER et al. High-resolution liquid chromatography of DNA fragments on non-porous
`poly(styrene-divinylbenzene) particles. Nucleic Acids Res. 1993 Mar 11;21(5):1061-6.
`
`KARLSSON et al. Amplification-free sequencing of cell-free DNA for prenatal non-invasive
`diagnosis of chromosomal aberrations. Genomics. 2015 Mar;105(3):150-8.
`
`KATO et al. A new packing for separation of DNA restriction fragments by high performance
`liquid chromatography. J Biochem. 1984 Jan;95(1):83-6.
`
`REUTER et al. Simul-seq: combined DNA and RNA sequencing for whole-genome and
`transcriptome profiling. Nat Methods. 2016 Nov; 13(11): 953—958. Manuscript; available 2017
`Dec 18.
`
`Examiner
`
`,I’TERESA E STRZELECKA/
`
`Date
`
`11115/2019
`
`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
`Translation is attached. This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
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`ALL REFERENCES CONSIDERED EXCEPT WERE LINED THROUGH .
`
`/T . E . S/
`
`

`

`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`15/952,293 _. GAU: 1637
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`
`Substitute for form 1449/PTO
`
`
`
`
`
`
`
`
`
`
`
`——'~ E
`
`Attorney Docket Number
`A 7697-709201
`
`
`INFORMATION DISCLOSURE
`
`STATEMENT BY APPLICANT
`(Use as many sheets as necessary)
`
`Complete if Known
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`
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`
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`NON-PATENT LITERATURE DOCUMENTS
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`Examiner
`Initials*
`
`.
`
`Include name ofthe author(in CAPITAL LETTERS),titIe of the article(when appropriate), title of
`the item (book,magazine,journal,serial,symposium,cata|og,etc.),date,page(s),vo|ume-issue
`number(s),publisher, city and/or country where published.
`
`
`
`
`SAUKKONEN, et al. Cell-free plasma DNA as a predictor of outcome in severe sepsis and
`septic shock. Clin Chem. 2008 Jun;54(6):1000-7. doi: 10.1373/clinchem.2007.101030. Epub
`2008 Apr 17.
`
`SONI, et al. Progress toward ultrafast DNA sequencing using solid-state nanopores. Clin Chem.
`2007 Nov;53(11):1996-2001. Epub 2007 Sep 21.
`
`Examiner
`
`Signature
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`/ TERE SA E STRZELE CKA/
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`Considered
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`1 l 5/ l 5 [’2 C) l 9
`
`Date
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`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
`Translation is attached. This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
`
`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH .,
`
`/T . E ., S/
`
`