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`US-20040106110
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`06 03-2004
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`BALASUBRAMAN IAN Shankar et al
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`US-20040209299
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`10-21-2004
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`PINTER; Jonathon H. et al.
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`1
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`4
`considered.
`lnclude copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
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`Documents at wwwusgtogov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). For Japanese patent documents, the
`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
`document under WlPO Standard ST.16 if possible. 6Applicant is to place a check mark here if English language Translation is attached. This collection of information is required by
`37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application. Confidentiality is
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`INFORMATION DISCLOSURE —g:;3V2V‘§/3MP Tmoth A
`STATEMENT BY APPLICANT —1674
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`US-20040106110
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`06 03-2004
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`BALASUBRAMAN IAN Shankar et al
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`US-20040209299
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`10-21-2004
`
`PINTER; Jonathon H. et al.
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`Examiner
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`Date
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`1
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`lnclude copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
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`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
`document under WlPO Standard ST.16 if possible. 6Applicant is to place a check mark here if English language Translation is attached. This collection of information is required by
`37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application. Confidentiality is
`governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the completed application
`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this
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`INFORMATION DISCLOSURE —g:;3V2V‘§/3MP Tmoth A
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`US-20060024678
`
`02 02-2006
`
`BUZBY Phlllp R
`
`US-20060024711
`
`02 02 2006
`
`LAPIDUS Stanley N et al
`
`US-20060078909
`
`04 13-2006
`
`SRINIVASAN; Malthreyan et al
`
`US-20100068711
`
`03 18 2010
`
`UMANSKY; Samuil R. et al
`
`US-20120021412
`
`01 26 2012
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`MELKONYAN; Hovsep et al.
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`US-20120077185
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`03-29 2012
`
`Examiner
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`Date
`Considered
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`1
`2
`*EXAMINER: lnitial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
`4
`considered.
`lnclude copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
`5
`Documents at wwwusgtogov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). For Japanese patent documents, the
`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
`document under WlPO Standard ST.16 if possible. 6Applicant is to place a check mark here if English language Translation is attached. This collection of information is required by
`37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application. Confidentiality is
`governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the completed application
`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this
`burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED
`FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
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`INFORMATION DISCLOSURE —g:;3V2V‘§/3MP Tmoth A
`STATEMENT BY APPLICANT —1674
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`(Use as many sheets as necessary)
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` OLIPHANT; Arnold et al.
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`INFORMATION DISCLOSURE —g:;3V2V‘§/3MP Tmoth A
`STATEMENT BY APPLICANT —1674
`y
`Not Yet Assigned
`Attorney Docket Number
`A 7697-709201
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`Ocume”
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`b
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`Number-Kind Code2 (”km")
`
`
`
`FOREIGN PATENT DOCUMENTS
`
`
`
`
`
`
`Examiner
`lnitials*
`
`.
`
`Foreign Patent Document
`
`Country Codea’NumberA’Kind Code5 (if known)
`
`EP—1856295-A2
`
`EP—1885877-A2
`
`EP-2351857-A1
`
`Publication
`Date
`MM-DD-YYYY
`
`08-03-2011
`
`11'21'2007
`
`02'13'2008
`
`Name of Patentee or
`Applicant of Cited Document
`
`Pages, Columns, Lines,
`Where Relevant Passages
`Or Relevant Figures Appear
`
`ISTITUTO NAZ PER
`LE MALATTIE I [IT]
`
`ISTITUTO NAZ PER
`LE MALATTIE I [IT]
`
`TROVAGENE INC
`
`[US]
`
`Examiner
`Signature
`
`Date
`Considered
`
`1
`2
`*EXAMINER: lnitial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
`4
`considered.
`lnclude copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
`5
`Documents at wwwusgtogov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). For Japanese patent documents, the
`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
`document under WlPO Standard ST.16 if possible. 6Applicant is to place a check mark here if English language Translation is attached. This collection of information is required by
`37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application. Confidentiality is
`governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the completed application
`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this
`burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED
`FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
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`—15952203
`_D t
`INFORMATION DISCLOSURE —g‘t/]3V2V‘Qfmp Tmoth A
`STATEMENT BY APPLICANT —1674
`y
`Not Yet Assigned
`Attorney Docket Number
`A 7697-709201
`
`.—
`
`(Use as many sheets as necessary)
`
`;
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`Examiner
`lnitials*
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`
`Foreign Patent Document
`
`Publication
`Date
`MM-DD-YYYY
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`Name of Patentee or
`Applicant of Cited Document
`
`Pages, Columns, Lines,
`Where Relevant Passages
`Or Relevant Figures Appear
`
`03
`
`FOREIGN PATENT DOCUMENTS
`
`Country Codea’Number’I’Kind Code5 (if known)
`
`WO-2012159023-A2
`
`11-22-2012
`
`WO-2012168815-A2
`
`12-13-2012
`
`UNIV VIRGINIA
`COMMONWEALTH
`
`[US], et al.
`KONINKL PHILIPS
`ELECTRONICS NV
`
`[NL], et al.
`
`WO-2013052907-A2
`
`04-11-2013
`
`[SUESQ]UENOM'NC
`
`WO-2013132305-A1
`
`WO-2013156627-A1
`
`WO-2013159035-A2
`
`UMVHONGKONG
`09-12-2013 CHINESHCN]
`
`10-24-2013
`
`PASTEUR
`INSTITUUFR]
`
`WISCONSIN MED
`10-24-2013 COLLEGE NC [US]
`
`WO-2013188846-A1
`
`12-19-2013
`
`STYHJHARRY
`
`[US]
`
`GUARDANT
`
`WO-2014039556-A1
`
`03-13-2014 HEALTH INC [US],
`et al.
`
`WO-2014068075-A1
`
`05-08-2014
`
`WO-2014149134-A2
`
`09-25-2014
`
`GENESUPPORT
`
`SA [CH]
`
`GUARDANT
`
`
`
`Examiner
`Signature
`
`HEALTH INC [US]
`
`Date
`Considered
`
`1
`2
`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
`4
`considered. Include copy of this form with next communication to applicant. Applicant’s unique citation designation number (optional). See Kinds Codes of USPTO Patent
`5
`Documents at wwwusgtogov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). For Japanese patent documents, the
`indication of the year of the reign of the Emperor must precede the serial number of the patent document. Kind of document by the appropriate symbols as indicated on the
`document under WIPO Standard ST.16 if possible. 6Applicant is to place a check mark here if English language Translation is attached. This collection of information is required by
`37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application. Confidentiality is
`governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the completed application
`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this
`burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED
`FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
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`
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`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
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`
`Substitute for form 1449/PTO
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`Complete if Known
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`NON-PATENT LITERATURE DOCUMENTS
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`Examiner
`Initials*
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`.
`
`Include name ofthe author(in CAPITAL LETTERS),titIe of the article(when appropriate), title of
`the item (book,magazine,journal,serial,symposium,cata|og,etc.),date,page(s),vo|ume-issue
`number(s),publisher, city and/or country where published.
`
`N
`
`CONSTANS, A. Beyond Sanger: Toward the $1,000 Genome.The Scientist. 30 June 2003;
`17(13): 36.
`
`DRMANAC, R. et al. Human genome sequencing using unchained base reads on self-
`assembling DNA nanoarrays. Science 327, 78-81 (20 1 0).
`
`GANSAUGE, et al. Single-stranded DNA library preparation forthe sequencing of ancient or
`damaged DNA. Nat Protoc. 2013 Apr;8(4):737-48. doi: 10.1038/nprot.2013.038. Epub 2013 Mar
`14.
`
`GARAJ, et al. Graphene as a sub-nanometertrans-electrode membrane. Nature. 2010
`September 9, 467.7312: 190-193. doi: 10.1038/nature09379.
`
`HIGHLANDER, Sarah K., High throughput sequencing methods for microbiome profiling:
`application to food animal systems, Animal Health Research Reviews, June 2012, Volume
`13(1); pages 40-53.
`
`HUBER et al. High-resolution liquid chromatography of DNA fragments on non-porous
`poly(styrene-divinylbenzene) particles. Nucleic Acids Res. 1993 Mar 11;21(5):1061-6.
`
`KARLSSON et al. Amplification-free sequencing of cell-free DNA for prenatal non-invasive
`diagnosis of chromosomal aberrations. Genomics. 2015 Mar;105(3):150-8.
`
`KATO et al. A new packing for separation of DNA restriction fragments by high performance
`liquid chromatography. J Biochem. 1984 Jan;95(1):83-6.
`
`REUTER et al. Simul-seq: combined DNA and RNA sequencing for whole-genome and
`transcriptome profiling. Nat Methods. 2016 Nov; 13(11): 953—958. Manuscript; available 2017
`Dec 18.
`
`Examiner
`Signature
`
`Date
`Considered
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`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
`Translation is attached. This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
`
`—15952203
`_D t
`—§:X3v2v?<1/3Mp Tmoth A
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT —1674
`y
`Not Yet Assigned
`Attorney Docket Number
`A 7697-709201
`
`.—
`
`(Use as many sheets as necessary)
`
`
`
`
`
`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`Substitute for form 1449/PTO
`_
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`Complete if Known
`
`;
`
`|
`
`.
`
`NON-PATENT LITERATURE DOCUMENTS
`
`.
`
`Include name ofthe author(in CAPITAL LETTERS),titIe of the article(when appropriate), title of
`the item (book,magazine,journal,serial,symposium,cata|og,etc.),date,page(s),vo|ume-issue
`number(s),publisher, city and/or country where published.
`
`SAUKKONEN, et al. Cell-free plasma DNA as a predictor of outcome in severe sepsis and
`septic shock. Clin Chem. 2008 Jun;54(6):1000-7. doi: 10.1373/clinchem.2007.101030. Epub
`2008 Apr 17.
`
`SONI, et al. Progress toward ultrafast DNA sequencing using solid-state nanopores. Clin Chem.
`2007 Nov;53(11):1996-2001. Epub 2007 Sep 21.
`
`Examiner
`Initials*
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`
`
`Examiner
`Signature
`
`Date
`Considered
`
`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include
`copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language
`Translation is attached. This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering,
`preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to
`complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, US. Patent and Trademark Office, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, P.0. Box 1450, Alexandria, VA 22313-1450.
`If you need assistance in completing the form, call 1-800—PTO-9199 (1 -800-786-91 99} and select option 2.
`
`
`
`—15952203
`_D t
`INFORMATION DISCLOSURE —g:;3V2V‘§/3MP Tmoth A
`STATEMENT BY APPLICANT —1674
`y
`Not Yet Assigned
`Attorney Docket Number
`A 7697-709201
`
`.—
`
`(Use as many sheets as necessary)
`
`
`
`Approved for use through 11/30/2020. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
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`Substitute for form 1449/PTO
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`—15952203
`_D t
`INFORMATION DISCLOSURE —g:;3V2V‘§/3MP Tmoth A
`STATEMENT BY APPLICANT —1674
`y
`Not Yet Assigned
`Attorney Docket Number
`A 7697-709201
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`(Use as many sheets as necessary)
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`Please see 37 CFR 1.97 and 1.98 to make the appropriate selection(s):
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`CERTIFICATION STATEMENT
`
`I:I
`
`That each item of information contained in the information disclosure statement was first cited in any
`communication from a foreign patent office in a counterpart foreign application not more than three months priorto
`the filing of the information disclosure statement. See 37 CFR 1.97(e)(1).
`
`That no item of information contained in the information disclosure statement was cited in a communication from a
`
`to the knowledge of the person signing the
`foreign patent office in a counterpart foreign application, and,
`certification after making reasonable inquiry, no item of information contained in the information disclosure
`statement was known to any individual designated in 37 CFR 1.56(c) more than three months prior to the filing of
`the information disclosure statement. See 37 CFR 1.97(e)(2).
`
`I:I
`
`See attached certification statement.
`
`I:I
`
`Fee set forth in 37 CFR 1.17 (p) has been submitted herewith.
`
`XI A certification statement is not submitted herewith.
`
`A signature of the applicant or representative is required in accordance with CFR 1.33, 10.18. Please see CFR 1.4(d) for
`the form ofthe signature.
`
`SIGNATURE
`
`Name/Print
`
`Derrick D. Rowe
`
`Registration Number
`
`73,674
`
`/Derrick D. Rowe/
`
`Date (YYYY-MM-DD)
`
`2018-04-17
`
`This collection of information is required by 37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit
`by the public which is to file (and by the USPTO to process) an application. Confidentiality is governed by 35 U.S.C. 122
`and 37 CFR1.14. This collection is estimated to take 1 hour to complete, including gathering, preparing and submitting the
`completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the
`amount of time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief
`Information Officer, US. Patent and Trademark Office, US. Department of Commerce, PO. Box 1450, Alexandria, VA
`22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissioner for
`
`Patents, P.O. Box 1450, Alexandria, VA 22313-1450.
`
`
`
`Privacy Act Statement
`
`The Privacy Act of 1974 (P.L. 93-579) requiresthat you be given certain information in connection with yoursubmission of
`the attached form related to a patent application or patent. Accordingly, pursuantto the requirements of the Act, please be
`advised that: (1) the general authority forthe collection ofthis information is 35 U.S.C. 2(b)(2); (2) furnishing ofthe information
`solicited is voluntary; and (3) the principal purpose for which the information is used bythe US. Patent and Trademark Office
`is to process and/or examine your submission related to a patent application or patent. If you do not furnish the requested
`information, the US. Patent and Trademark Office may not be able to process and/or examine your submission, which may
`result in termination of proceedings or abandonment of the application or expiration ofthe patent.
`
`The information provided by you in this form will be subject to the following routine uses:
`
`
`
`A record from this system of records may be disclosed, as a routine use, in the course of presenting evidence to a
`court, magistrate, or administrative tribunal, including disclosures to opposing counsel in the course of settlement
`negotiations.
`A record in this system of records may be disclosed, as a routine use, to a Member of Congress submitting a request
`involving an individual, to whom the record pertains, when the individual has requested assistance from the Member
`with respect to the subject matter of the record.
`A record in this system of records may be disclosed, as a routine use, to a contractor ofthe Agency having need
`forthe information in orderto perform a contract. Recipients of information shall be required to comply with the
`requirements ofthe Privacy Act of 1974, as amended, pursuant to 5 U.S.C. 552a(m).
`A record related to an International Application filed underthe Patent Cooperation Treaty in this system of records
`may be disclosed, as a routine use, to the International Bureau of the World Intellectual Property Organization,
`pursuant to the Patent Cooperation Treaty.
`A record in this system of records may be disclosed, as a routine use, to anotherfederal agency for purposes of
`National Security review (35 U.S.C. 181) and for review pursuant to the Atomic Energy Act (42 U.S.C. 218(c)).
`. A record from this system of records may be disclosed, as a routine use, to the Administrator, General Services, or
`his/her designee, during an inspection of records conducted by GSA as part ofthat agency's responsibility to
`recommend improvements in records management practices and programs, under authority of 44 U.S.C. 2904
`and 2906. Such disclosure shall be made in accordance with the GSA regulations governing inspection of records
`for this purpose, and any other relevant (i.e., GSA or Commerce) directive. Such disclosure shall not be used to
`make determinations about individuals.
`
`1. The information on this form will be treated confidentially to the extent allowed underthe Freedom of Information Act
`(5 U.S.C. 552) and the Privacy Act (5 U.S.C 552a). Records from this system of records may be disclosed to the
`Department ofJustice to determine whether disclosure ofthese records is required by the Freedom of Information
`Act.
`
`. A record from this system of records may be disclosed, as a routine use, to the public after either publication of
`the application pursuant to 35 U.S.C. 122(b) or issuance ofa patent pursuantto 35 U.S.C. 151. Further, a record
`may be disclosed, subject to the limitations of37 CFR 1.14, as a routine use, to the public ifthe record was filed
`in an application which became abandoned or in which the proceedings were terminated and which application is
`referenced by eithera published application, an application opento public inspection or an issued patent.
`A record from this system of records may be disclosed, as a routine use, to a Federal, State, or local law
`enforcement agency, ifthe USPTO becomes aware of a violation or potential violation of law or regulation.
`
`
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