(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
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`(19) World Intellectual Property Organization
`International Bureau
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`(43) International Publication Date
`6 March 2008 (06.03.2008)
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`
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`(10) International Publication Number
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`WO 2008/025791 A1
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`[US/US]; 25 Windrose Way, Greenwich, CT 06830 (US).
`WALDEN, Malcolm [GB/GB]; c/o Mundipharma Re—
`search Limited, Cambridge Science Park, Milton Road,
`Cambridge CB4 OGW (GB).
`
`Agent: BUEHLER, Dirk; Elisenhof, Elisenstrasse 3,
`80335 Miinehen (DE).
`
`Designated States (unless otherwise indicated, for ever
`kind of national protection available): AE, AG, AL, AM,
`AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH,
`CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG,
`ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL,
`IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK,
`LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW,
`MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL,
`PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY,
`TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA,
`ZM, ZW.
`
`Designated States (unless otherwise indicated, for ever
`kind of regional protection available): ARIPO (BW, GH,
`GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM,
`ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM),
`European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI,
`FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL,
`PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM,
`GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
`
`(74)
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`(81)
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`(84)
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`Published:
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`with international search report
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`(51) International Patent Classification:
`A61K 31/485 (2006.01)
`A61K 9/20 (2006.01)
`A61P 25/04 (2006.01)
`A61K 9/70 (2006.01)
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`(21) International Application Number:
`PCT/EP2007/058978
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`(22) International Filing Date: 29 August 2007 (29.08.2007)
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`(25) Filing Language:
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`(26) Publication Language:
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`English
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`English
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`(30) Priority Data:
`061198396
`
`30 August 2006 (30.08.2006)
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`EP
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`(71) Applicant (for all designated States except US): EURO-
`CELTIQUE S.A. [LU/LU]; 122, Boulevard de la Pétrusse,
`L—2330 Luxembourg (LU).
`
`(72) Inventors; and
`(75) Inventors/Applicants (for US only): OKSCHE, Alexan-
`der [DE/DE]; Birkenstr.
`22, 65550 Limburg (DE).
`HEATH, William [GB/GB]; c/o Napp Pharmaceuticals
`Limited, Cambridge Science Park, Milton Road, Cam—
`bridge, CB4 OGW (GB). HOLDEN, Timothy [GB/GB];
`c/o Napp Pharmaceuticals Limited, Cambridge Sci—
`ence Park, Milton Road, Cambridge, CB4 OGW (GB).
`PRATER, Derek A. [GB/GB]; c/o Mundipharma Re
`search Limited, Cambridge Science Park, Milton Road,
`Cambridge, CB4 OGW (GB). SACKLER, Richard S.
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`
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`(54) Title: BUPRENOPHlNE—WAFER FOR DRUG SUBSTITUTION THERAPY
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`(57) Abstract: The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form
`releasing buprenorphine instantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates
`to the use of such dosage forms for treating pain in a human or animal or for drug substitution therapy in drug dependent human
`subjects.
`
`