`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 1 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`U. S. PATENTS
`
`
`
`EXAMINER
`INITIALS
`
`PATENT
`NUMBER
`
`ISSUE DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 2 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`U. S. PATENTS
`
`
`
`EXAMINER
`INITIALS
`
`PATENT
`NUMBER
`
`ISSUE DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 3 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`U. S. PATENTS
`
`
`
`EXAMINER
`INITIALS
`
`PATENT
`NUMBER
`
`ISSUE DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 4 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`U. S. PATENTS
`
`
`
`EXAMINER
`INITIALS
`
`PATENT
`NUMBER
`
`ISSUE DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 5 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`U. S. PATENTS
`
`
`
`EXAMINER
`INITIALS
`
`PATENT
`NUMBER
`
`ISSUE DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-—— Wm
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`-_ 2009-09-29
`EXAMINER
`SIGNATURE:
`
`Lee et a1.
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 6 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`U. S. PATENTS
`
`
`
`EXAMINER
`INITIALS
`
`PATENT
`NUMBER
`
`ISSUE DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-———
`
`-———
`-———
`-———
`-———
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`20020151040
`2002-10-17
`O’Keefe et a1.
`
`20020164820
`
`2002-11-07
`
`Brown
`
`20020195586
`
`2002-12-26
`
`Auslander et a1.
`
`20030001121
`
`2003-01-02
`
`Hochstein
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 7 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`US. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-_— Enzelberger et a1.
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`-_ 2005-02-24
`
`Knapp et a1.
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 8 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`US. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 9 OF 33
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`US. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 10 OF
`
`3
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`US. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`-_ 2009-02-05
`
`Mathies et a1.
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 11 OF
`
`3
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`US. PATENT APPLICATION PUBLICATIONS
`
`
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-———
`-———
`-———
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 12 OF
`
`3
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-_— Colston, Jr. et a1.
`-_— Colston, Jr. et a1.
`-_ 2011-05-19
`Eshoo et a1.
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET 13 OF
`
`3
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`US. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET A OF
`
`3
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`US. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-———
`-———
`-———
`-———
`-———
`-———
`-———
`-———
`-———
`
`
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`1522582A2
`
`EP
`
`2005-04-13
`
`1522582B1
`
`EP
`
`2007-04-07
`
`Medical
`Research
`Council
`
`Medical
`Research
`Council
`
`-
`
`2097692
`
`1982-11-10
`
`--
`
`0295433
`
`JP
`
`1990-04-06
`
`Miyazaki Pref
`Gov
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`
`SHEET A OF
`
`3
`
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`2011041925
`
`JP
`
`2011-03-03
`
`Hitachi Plant
`
`Technologies
`Ltd.
`
`
`
`94/05414
`
`W0
`
`1994-03-17
`
`98/ 1 63 13
`
`W0
`
`1998-04-23
`
`98/44152
`
`W0
`
`1998-10-08
`
`98/44151
`
`W0
`
`1998-10-08
`
`0 1/ 12327
`
`W0
`
`2001-02-22
`
`02/23163
`
`W0
`
`2002-03 -21
`
`The Regents of
`the University of
`California
`
`Central Research
`Laboratories Ltd.
`
`Glaxo Group
`Limited
`
`Glaxo Group
`Limited
`
`Ut-Bat-Telle,
`LLC
`
`California
`Institute of
`
`Technology
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET 16 OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
` 2004/040001
`
`02/068104
`
`W0
`
`2002-09-06
`
`02/081729
`
`W0
`
`2002-10-17
`
`02/081490
`
`W0
`
`2002-10-17
`
`Japanese Science
`and Technology
`Corporation
`
`California
`Institute of
`
`Technology
`
`Egea
`Biosciences, Inc.
`
`03/016558
`
`W0
`
`2003-02-27
`
`Corbett Research
`
`03/042410
`
`2003-05-22
`
`Pty. Ltd.
`
`Samsung
`Electronics Co.,
`Ltd.
`
`03/072258
`
`2003-09-04
`
`Cartesian
`
`W0
`
`2004-05 -13
`
`2005/007812
`
`2005-01-27
`
`Technologies,
`Inc .
`
`California
`Institute of
`
`Technology
`
`University of
`Medicine and
`
`Dentistry of New
`Jersey et al.
`
`2005/010145
`
`2005-02-03
`
`The Johns
`
`2005/021151
`
`2005-03-10
`
`Hopkins
`University
`
`President and
`Fellows of
`
`EXAMINER
`SIGNATURE:
`
`Harvard College
`
`DATE
`CONSIDERED:
`
`
`
`FORMPTO-1449
`
`Application Number: 15/707,908
`
`SHEET 1 OF A
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`
`
`2005/023091
`
`W0
`
`2005-03-17
`
`2005/055807
`
`W0
`
`2005-06-23
`
`2005/075683
`
`W0
`
`2005-08-18
`
`2006/023719
`
`W0
`
`2006-03-02
`
`2006/027757
`
`W0
`
`2006-03-16
`
`2006/038035
`
`W0
`
`2006-04-13
`
`The Trustees of
`Boston
`
`University et al.
`
`Beatrice and
`Samuel A.
`Seaver
`Foundation
`
`Postech
`Foundation
`
`ENH Research
`Institute
`
`Institut Curie et
`al.
`
`Medical
`Research
`Council et al.
`
`2006/086777
`
`W0
`
`2006-08-17
`
`Memorial Sloan
`
`2007/092473
`
`W0
`
`2007-08-16
`
`Kettering Cancer
`Center
`
`The Board of
`Trustees of the
`Leland Stanford
`Junior Univ.
`
`2007/091230
`2007/091228
`
`2007-08-16
`2007-08-16
`
`Stokes Bio Ltd. --
`Stokes Bio Ltd. --
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET A OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`2007/133710
`
`W0
`
`2007-11-22
`
`Rain-Dance
`
`2008/021123
`
`W0
`
`2008-02-21
`
`Technologies,
`Inc.
`
`President and
`Fellows of
`
`Harvard College
`
`2008/024114
`
`W0
`
`2008-02-28
`
`Genizon
`
`Biosciences, Inc.
`
`2008/063227
`
`W0
`
`2008-05-29
`
`Rain-Dance
`
`2008/070074
`
`W0
`
`2008-06-12
`
`2008/109878
`
`W0
`
`2008-09-12
`
`2008/109176
`
`W0
`
`2008-09-12
`
`Technologies,
`Inc.
`
`PGX-Health
`LLC
`
`California
`Institute of
`
`Technology
`
`President and
`Fellows of
`
`Harvard College
`
`
`
`2008/112177
`
`W0
`
`2008-09-18
`
`Genizon
`
`2009/002920
`
`W0
`
`2008-12-31
`
`2009/015863
`
`W0
`
`2009-02-05
`
`Biosciences, Inc.
`
`Advanced Liquid
`Logic Inc.
`
`F. Hoff-Man-La
`Roche AG
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET i OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`2009/049889
`
`W0
`
`2009-04-23
`
`Roche
`
`2009/085246
`
`W0
`
`2009-07-09
`
`Diagnostics
`GmbH
`
`University of
`Massachusetts
`
`EHF
`
`2010/018465
`2011/034621
`
`2010-02-18
`2011-03-24
`
`Stokes Bio Ltd. --
`Akonni
`
`2011/079176
`
`W0
`
`2011-06-30
`
`Rain-Dance
`
`Biosystems
`
`Technologies,
`Inc.
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`3M SPECIALTY MATERIALS, “3M Fluorinert Electronic Liquid FC-3283,”
`product information guide, issued August 2001
`
`ABATE, ADAM R. et a1., “Functionalized glass coating for PDMS
`microfluidic devices,” Lab on a Chip Technology: Fabrication and
`Microfluidics, 11 pgs., (2009)
`
`ABDELGAWAD, MOHAMED etal., “All-terrain dropletactuation,” Lab on a -
`
`Chip, Vol. 8, pgs. 672-677, April 2, 2008
`
`ALEXANDRIDIS, PASCHALIS, “Structural Polymorphism of Poly(ethylene
`oxide)-Poly(propylene oxide) Block Copolymers in Nonaqueous Polar
`Solvents, Macromolecules, Vol. 31, No. 20, pgs. 6935-6942, September 12,
`1998
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET 20 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`T
`
`5%
`
`
`
`ANNA, SHELLEY L. et al., “Formation of dispersions using “flow focusing”
`in microchannels,” Applied Physics Letters, Vol. 82, No. 3, January 20, 2003
`
`APPLIED BIOSYSTEMS, "Operator's Manual Tempo Nano LC Tempo
`NanaTano MDLC Systems", January 1, 2005, 74 pages
`
`AVILION, ARIEL A. et al., “Human Telomerase RNA and Telomerase
`
`Activity in Immortal Cell Lines and Tumor Tissues,” Cancer Research 56, pgs.
`645-650, February 1, 1996
`
`BAROUD, CHARLES N. et al., “Thermocapillary valve for droplet production
`and sorting,” Physical Review E 75, 046302, pgs. 046302-1 — 046302-5, April
`5, 2007
`
`BEER, N. REGINALD et al., “On-Chip Single-Copy Real-Time Reverse-
`Transcription PCR in Isolated Picoliter Droplets,” Analytical Chemistry, Vol.
`80, No.6, pgs. 1854-1858, March 15, 2008
`
`BEER, N. REGINALD et al., “On-Chip, Real-Time, Single-Copy Polymerase
`Chain Reaction in Picoliter Droplets,” Analytical Chemistry, Vol. 79, No. 22,
`pgs. 8471-8475, November 15, 2007
`
`BEER, NEIL REGINALD et al., “Monodisperse droplet generation and rapid
`trapping for single molecule detection and reaction kinetics measurement,” Lab
`on a Chip, Vol. 9, pgs. 841-844, December 5, 2008
`
`BHAT, SOMANATH et al., “Effect of sustained elevated temperature prior to
`amplification on template copy number estimation using digital polymerase
`chain reaction,” Analyst, Vol. 136, pgs. 724-732, (2011)
`
`BLOW, NATHAN, “PCR’s next frontier,” Nature Methods, Vol. 4, No. 10,
`
`pgs. 869-875, October 2007
`
`BRANSKY, AVISHAY et al., “A microfluidic droplet generator based on a
`piezoelectric actuator,” Lab on a Chip, Vol. 9, pgs. 516-520,
`November 20, 2008
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET A OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`CARROLL, NICK J. et al., “Droplet-Based Microfluidics for Emulsion and
`Solvent Evaporation Synthesis of Monodisperse Mesoporous Silica
`Microspheres,” Langmuir, Vol. 24, No. 3, pgs. 658-661, January 3, 2008
`
`CAWTHON, RICHARD M., “Telomere length measurement by a novel
`monochrome multipleX quantitative PCR method,” Nucleic Acids Research,
`Vol. 37, No. 3, pgs. 1-7, (2009)
`
`CAWTHON, RICHARD M., “Telomere measurement by quantitative PCR,”
`Nucleic Acids Research, Vol. 30, No. 10, pgs. 1-6, (2002)
`
`CHABERT, MAX et al., “Droplet fusion by alternating current (AC) field
`electrocoalescence in microchannels,” Electrophoresis, Vol. 26, pgs. 3706-
`3715, (2005)
`
`CHEN, CHIA-HUNG et al., “Janus Particles Templated from Double Emulsion
`Droplets Generated Using Microfluidics,” Langmuir, Vol. 29, No. 8, pgs. 4320-
`4323, March 18, 2009
`
`CHEN, DELAI L. et al., “Using Three-Phase Flow of Immiscible Liquids to
`Prevent Coalescence of Droplets in Microfluidic Channels: Criteria to Identify
`the Third Liquid and Validation with Protein Crystallization,” Langmuir, Vol.
`23, No. 4, pgs. 2255-2260, (2007)
`
`CHITTOFRATI, A. et al., “Perfluoropolyether microemulsions,” Progress in
`Colloid & Polymer Science 79, pgs. 218-225, (1989)
`
`Chloroform (Phenomenex), Solvent Miscibility Table, Internet Archive
`WayBackMachine, 3 pgs., February 1, 2008
`
`CLAUSELL-TORMOS, JENIFER et al., “Droplet-Based Microfluidic
`Platforms for the Encapsulation and Screening of Mammalian Cells and
`Multicellular Organisms,” Chemistry & Biology, Vol. 15, pgs. 427-437, May
`2008
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET 22 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`DA ROCHA, SANDRO R. P. et al., “Effect of Surfactants on the Interfacial
`Tension and Emulsion Formation between Water and Carbon Dioxide,”
`
`Langmuir, Vol. 15, No. 2, pgs. 419-428, (1999), published on web
`December 29, 1998
`
`DASGUPTA, PURNENDU K. et al., “Light emitting diode-based detectors
`Absorbance, fluorescence and spectroelectrochemical measurements in a planar
`flow-through cell,” Analytica Chimica Acta 500, pgs. 337-364, (2003)
`
`DIEHL, FRANK et al., “Digital quantification of mutant DNA in cancer
`patients,” Current Opinion in Oncology, Vol. 19, pgs. 36-42, (2007)
`
`DIEKEMA, DANIEL J. et al., “Look before You Leap: Active Surveillance for
`Multidrug-Resistant Organisms,” Healthcare Epidemiology ~ CID 2007:44, pgs.
`1101-1107 (15 April), electronically published March 2, 2007
`
`DING, CHUNMING et al., “Direct molecular haplotyping of long-range
`genomic DNA with Ml-PCR,” PNAS, Vol. 100, No. 13, pgs. 7449-7453, June
`24, 2003
`
`DORFMAN, KEVIN D. et al., “Contamination-Free Continuous Flow
`
`Microfluidic Polymerase Chain Reaction for Quantitative and Clinical
`Applications,” Analytical Chemistry Vol. 77, No. 11, pgs. 3700-3704, June 1,
`2005
`
`DRESSMAN, DEVIN et al., “Transforming single DNA molecules into
`fluorescent magnetic particles for detection and enumeration of genetic
`variations,” PNAS, Vol. 100, No. 15, July 22, 2003
`
`DUBE, SIMANT et al., “Mathematical Analysis of Copy Number Variation in
`a DNA Sample Using Digital PCR on a Nanofluidic Device,” PLoS ONE, Vol.
`3, Issue 8, pgs. 1-9, August 6, 2008
`
`EKSIGENT, "Product Note Eksigent: NanoFlow Metering System", January 1,
`2010, 4 pages
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET 23 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`EMERSON, DAVID et al., “Microfluidic Modelling Activities at C3M,” Centre
`for Microfluidics & Microsystems Modelling, Daresbury Laboratory, pgs. 1-26,
`May 15, 2006
`
`ESCHENBACK OPTIK GMBH, “Optics for Concentrated Photovoltaics
`(CPV), 1 pg., date unknown
`
`FAN, JIAN-BING et al., “Highly parallel genomic assays,” Nature
`Reviews/Genetics, Vol. 7, pgs. 632-644, August 2006
`
`FIDALGO, LUIS M. et al., “Coupling Microdroplet Microreactors with Mass
`Spectrometry: Reading the Contents of Single Droplets Online,” Angewandte
`Chemie, Vol. 48, pgs. 3665-3668, April 7, 2009
`
`FIELDEN, PETER et al., “Micro-Droplet Technology for High Throughout
`Systems and Methods,” 1 pg., March 8, 2006
`
`GARSTECKI, PIOTR et al., “Formation of droplets and bubbles in a
`microfluidic T-j unction — scaling and mechanism of break-up,” Lab on a Chip,
`Vol. 6, pgs. 437-446, (2006)
`
`GARSTECKI, PIOTR et al., “Mechanism for Flow-Rate Controlled Breakup in
`Confined Geometries: A Route to Monodisperse Emulsions,” Physical Review
`Letters, 164501, pgs. 164501-1 — 164501-4, April 29, 2005
`
`GARTI, N. et al., “Water Solubilization in Nonionic Microemulsions Stabilized
`
`by Grafted Siliconic Emulsifiers,” Journal of Colloid and Interface Science Vol.
`233, pgs. 286-294, (2001)
`
`GASPERLIN, M. et al., “The structure elucidation of semisolid w/o emulsion
`
`systems containing silicone surfactant,” International Journal of Pharmaceutics
`107, pgs. 51-56, (1994)
`
`GE, QINYU et al., “Emulsion PCR—based method to detect Y chromosome
`microdeletions,” Analytical Biochemistry, Vol. 367, pgs. 173-178,
`May 10, 2007
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET A OF A
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`NON-PATENT LITERATURE DOCUMENTS
`
`I
`
`GHENCIU, E. G. et al., “Affinity Extraction into Carbon Dioxide. 1. Extraction
`of AVidin Using a Biotin-Functional Fluoroether Surfactant,” Ind. Eng. Chem.
`Res. Vol. 36, No. 12, pgs. 5366-5370, December 1, 1997
`
`GLOTSOS, DIMITRIS et al., “Robust Estimation of Bioaffinity Assay
`Fluorescence Signals,” IEEE Transactions on Information Technology in
`Biomedicine, Vol. 10, No. 4, pgs. 733-739, October 2006
`
`GOLDSCHMIDT GMBH, “Abil® EM 90 Emulsifier for the formulation of
`
`cosmetic W/O creams m lotions,” degussa. creating essentials brochure, pgs.
`1-7, May 2003
`
`GRIFFITHS, ANDREW D. et al., “Miniaturising the laboratory in emulsion
`droplets,” TRENDS in Biotechnology, Vol. 24, No. 9, pgs. 395-402, July 14,
`2006
`
`GULLBERG, MATS et al., “Cytokine detection by antibody-based proximity
`ligation,” PNAS, Vol. 101, No. 22, pgs. 8420-8424, June 1, 2004
`
`GUO, ZHEN et al., “Enhanced discrimination of single nucleotide
`polymorphisms by artificial mismatch hybridization,” Nature Biotechnology
`Vol. 15, pgs. 331-335, April 1997
`
`GUSTAFSDOTTIR, SIGRUN M. et al., “In Vitro analysis of DNA-protein
`interactions by proximity ligation,” PNAS, Vol. 104, No. 9, pgs. 3067-3072,
`February 27, 2007
`
`HIGUCHI, RUSSELL et al., “Kinetic PCR Analysis: Real-time Monitoring of
`DNA Amplification Reactions,” Bio/Technology Vol. II, pgs. 1026-1030,
`September 11, 1993
`
`HILL, RANDLA M., “Silicone surfactants — new developments,” Current
`Opinion in Colloid & Interface Science 7, pgs. 255-261, (2002)
`
`HOBBS, HELEN R. et al., “Homogeneous Biocatalysis in both Fluorous
`Biphasic and Supercritical Carbon Dioxide Systems,” Angewandte Chemie,
`Vol. 119, pgs. 8006-8009, September 6, 2007
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET A OF A
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`NON-PATENT LITERATURE DOCUMENTS
`
`I
`
`HOLTZE, C. et al., “Biocompatible surfactants for water-in-fluorocarbon
`emulsions,” Lab on a Chip, Vol. 8, pgs. 1632-1639, September 2, 2008
`
`HORI, MACHIKO et al., “Uniform amplification of multiple DNAs by
`emulsion PCR,” Biochemical and Biophysical Research Communications, Vol.
`352, pgs. 323-328, (2007)
`
`HUANG, JIAQI et al., “Rapid Screening of Complex DNA Samples by Single-
`Molecule Amplification and Sequencing,” PLoS ONE, Vol. 6, Issue 5, pgs. 1-4,
`May 201 1
`
`HUNG, LUNG-HSIN et al., “Rapid microfabrication of solvent-resistant
`biocompatible microfluidic devices,” Lab on a Chip, Vol. 8, pgs. 983-987, April
`8, 2008
`
`JARVIUS, JONAS et al., “Digital quantification using amplified single-
`molecule detection,” Nature Methods, Vol. 3, No. 9, pgs. 15 pgs, September
`2006
`
`JIN, DAYONG et al., “Practical Time-Gated Luminescence Flow Cytometry.
`11: Experimental Evaluation Using UV LED Excitation,” Cytometry Part A ~
`71A, pgs. 797-808, August 24, 2007
`
`KALININA, OLGA et al., “Nanoliter scale PCR with TaqMan Detection,”
`Nucleic Acids Research, Vol. 25, No. 10 pgs. 1999-2004, (1997)
`
`KATSURA, SHINJI et al., “Indirect micromanipulation of single molecules in
`water-in-oil emulsion,” Electrophoresis, Vol. 22, pgs. 289-293, (2001)
`
`KEKEVI, BURCU et al., “Synthesis and Characterization of Silicone-Based
`Surfactants as Anti-Foaming Agents, J. Surfact Deterg (2012), Vol. 15, pgs. 73-
`81, published online July 7, 2011
`
`KISS, MARGARET MACRIS et al., “High-Throughput Quantitative
`Polymerase Chain Reaction in Picoliter Droplets,” Analytical Chemistry, 8 pgs.,
`downloaded November 17, 2008
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET A OF A
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`KUMARESAN, PALANI et al., “High-Throughput Single Copy DNA
`Amplification and Cell Analysis in Engineered Nanoliter Droplets,” Analytical
`Chemistry, 17 pgs., April 15, 2008
`
`KUNIEDA, HIRONOBU et al., “Effect of Hydrophilic- and Hydrophobic-
`Chain Lengths on the Phase Behavior of A-B-type Silicone Surfactants in
`Water,” J. Phys. Chem. B, Vol. 105, No. 23, pgs. 5419-5426, (2001)
`
`LABSMITH, “CapTiteTM Microfluidic Interconnects” webpage, downloaded
`July 11, 2012
`
`LABSMITH, “Microfluid Components” webpage, downloaded July 11, 2012
`
`LANDEGREN, ULF et al., “Padlock and proximity probes for in situ and array-
`based analyses: tools for the post-genomic era,” Comp. Funct. Genom, Vol. 4,
`pgs. 525-530, (2003)
`
`LEAMON, JOHN H. et al., “Overview: methods and applications for droplet
`compartmentalization of biology,” Nature Methods, Vol. 3, No. 7, pgs. 541-
`543, July 2006
`
`LIN, YEN-HENG et al., “Droplet Formation Utilizing Controllable Moving-
`Wall Structures for Double-Emulsion Applications,” Journal of
`Microelectromechanical Systems, Vol. 17, No. 3, pgs. 573-581, June 2008
`
`LINK, DARREN R. et al., “Electric Control of Droplets in Microfluidic
`Devices,” Angewandte Chemie Int. Ed., Vol. 45, pgs. 2556-2560, (2006)
`
`LIU, KAN et al., “Droplet-based synthetic method using microflow focusing
`and droplet fiJsion,” Microfluid Nanfluid, Vol. 3, pgs. 239-243, (2007),
`published online September 22, 2006
`
`L0, Y. M. DENNIS et al., “Digital PCR for the molecular detection of fetal
`chromosomal aneuploidy,” PNAS, Vol. 104, No. 32, pgs. 13116-13121, August
`7, 2007
`
`LUK, VIVIENNE N. et al., “Pluronic Additives: A Solution to Sticky Problems
`in Digital Microfluidics,” Langmuir, Vol. 24, No. 12, pgs. 6382-6289, May 16,
`2008
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET L OF A
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`NON-PATENT LITERATURE DOCUMENTS
`
`I
`
`MARGULIES, MARCEL et al., “Genome sequencing in microfabricated high-
`density picolitre reactors,” NATURE, Vol. 437, 51 pgs., September 15, 2005
`
`MARKEY, AMELIA L. et al., “High-throughput droplet PCR,” Methods, Vol.
`50, pgs. 277-281, February 2, 2010
`
`MAZUTIS, LINAS et al., “A fast and efficient microfluidic system for highly
`selective one-to-one droplet fiJsion,” Lab on a Chip, Vol. 9, pgs. 2665-2672,
`June 12, 2009
`
`MAZUTIS, LINAS et al., “Droplet-Based Microfluidic Systems for High-
`Throughput Single DNA Molecule Isothermal Amplification and Analysis,”
`Analytical Chemistry, Vol. 81, No. 12, pgs. 4813-4821, June 15, 2009
`
`MCCAUGHAN, FRANK et al., “Single-molecule genomics,” Journal of
`Pathology, Vol. 220, pgs. 297-306, November 19, 2009
`
`MEHTA, SOMIL C. et a., “Mechanism of Stabilization of Silicone Oil — Water
`
`Emulsions Using Hybrid Siloxane Polymers,” Langmuir, Vol. 24, No. 9, pgs.
`4558-4563, March 26, 2008
`
`MOHR, S. et al., “Numerical and experimental study of a droplet-based PCR
`chip,” Microfluid Nanofluid, Vol. 3, pgs. 611-621, (2007)
`
`MUSYANOVYCH, ANNA et al., “Miniemulsion Droplets as Single Molecule
`Nanoreactors for Polymerase Chain Reaction,” Biomacromolecules, Vol. 6, No.
`4, pgs. 1824-1828, (2005)
`
`NAGAI, HIDENORI et al., “Development of A Microchamber Array for
`Picoliter PCR,” Analytical Chemistry, Vol. 73, No. 5, pgs. 1043-1047, March 1,
`2001
`
`NAM, YOON SUNG et al., “Nanosized Emulsions Stabilized by Semisolid
`Polymer Interphase,” Langmuir, ACS Publications, July 23, 2010
`
`NEWMAN, D.A. et al., “Phase Behavior of Fluoroether-Functional
`
`Amphiphiles in Supercritical Carbon Dioxide,” The Journal of Supercritical
`Fluids, Vol. 6, No. 4, pgs. 205-210, (1993)
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET 28 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`NIE, SHUMING et al., “Optical Detection of Single Molecules,” Annu. Rev.
`Biophys. BiomoL Struct. Vol. 26, pages 567-596, (1997)
`
`O’LENICK, ANTHONY J. JR., “Silicone Emulsions and Surfactants,” Journal
`
`of Surfactants and Detergents, Vol. 3, No. 3, July 2000
`
`O’LENICK, ANTHONY J ., JR., “Silicone Emulsions and Surfactants — A
`
`Review,” Silicone Spectator, Silitech LLC, May, 2009 (original published May
`2000)
`
`PAMME, NICOLE, “continuous flow separations in microfluidic devices,” Lab
`on a Chip, Vol. 7, pgs. 1644-1659, November 2, 2007
`
`PIATYSZEK, MIECZYSLAW A. et al., “Detection of telomerase activity in
`human cells and tumors by a telomeric repeat amplification protocol (TRAP),”
`Methods in Cell Science 17, pgs. 1-15, (1995)
`
`PINHEIRO, LEONARDO B. et al., “Evaluation of a Droplet Digital
`Polymerase Chain Reaction Format for DNA Copy Number Quantification,”
`Analytical Chemistry, Vol. 84, pgs. 1003-1011, November 28, 2011
`
`POHL, GUDRUN et al., “Principle and applications of digital PCR” review,
`www.future-drugs.com, Expert Rev. Mol. Diagn. 4(1), pgs. 41-47, (2004)
`
`Polydimethylsiloxane, 5 pgs., published in FNP 52 (1992)
`
`PRICE, CHRISTOPHER B., “Regular Review Point of Care Testing,” BMJ,
`Vol. 322, May 26, 2001
`
`QIN, JIAN et al., “Studying copy number variations using a nanofluidic
`platform,” Nucleic Acids Research, Vol. 36, No. 18, pgs. 1-8, August 18, 2008
`
`ROACH, L. SPENCER et al., “Controlling Nonspecific Protein Absorption in a
`Plug-Based Microfluidic System by Controlling Interfacial Chemistry Using
`Fluorous-Phase Surfactants,” Analytical Chemistry Vol. 77, No. 3, pgs. 785-
`796, February 1, 2005
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`
`
`FORM PTO-1449
`
`Application Number: 15/707,908
`
`SHEET 29 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: September 18, 2017
`.
`First Named Inventor: Amy L. HIDDES SEN
`
`Art Unit: 1797
`
`Examiner: Jennifer WECKER
`
`Atty. Docket No. QLI3A05
`
`NON-PATENT LITERATURE DOCIHVIENTS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`RUTLEDGE, R. G. et al., “Mathematics of quantitative kinetic PCR and the
`application of standard curves,” Nucleic Acids Research, Vol. 31, No. 16, pgs.
`1-6, (2003)
`
`RUTLEDGE, R. G., “Sigmoidal curve-fitting redefines quantitative real-time
`PCR with the prospective of developing automated high-throughput
`applications,” Nucleic Acids Research. Vol. 32, No. 22, pgs. 1-8, (2004)
`
`SCHERER, A., California Institute of Technology, “Polymerase Chain
`Reactors” PowerPoint presentation, 24 pgs., date unknown
`
`SCHNEEGAB, IVONNE et al., “Miniaturized flow-through PCR with different
`template types in a silicon chip thermocycler,” Lab on a Chip, Vol. 1, pgs. 42-
`49, (2001)
`
`SCHROEDER, GROFF M. et al., “Introduction to Flow Cytometry” version
`5.1, 182 pgs. (2004)
`
`SCHUTZE, TATJANA et al., “A streamlined protocol for emulsion polymerase
`chain reaction and subsequent purification,” Analytical Biochemistry, Vol. 410,
`pgs. 155-157, November 25, 2010
`
`SELA, Y. et al., “Newly designed polysiloxane-graft-poly (oxyethylene)
`copolymeric surfactants: preparation, surface activity and emulsification
`properties,” Colloid & Polymer Science 272, pgs. 684-691, (1994)
`
`SHAH, RHUTESH K. et al., “Polymers fit for function Making emulsions drop
`by drop,” Materials Today, Vol. 11, No. 4, pgs. 18-27, April 2008
`
`SHENDURE, JAY et al., “Next-generation DNA sequencing,” Nature
`Biotechnology, Vol. 26, No. 10, pgs. 1135-1145, October 2008
`
`SHUBER, ANTHONY P. et al., “A Simplified Procedure for Developing
`Multiplex PCRs,” Genome Research, published by Cold Spring Harbor
`Laboratory Press, pgs. 488-493, (1995)
`
`SIGMA-ALDRICH, “Synthesis of Mesoporous Materials