U.S. Serial No. 15/603,013
`Response to Final Office Action dated November7, 2018
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`Attorney Docket No. 44854-701.402
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`AMENDMENTSTO THE CLAIMS
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`This listing of claims will replace all prior versions, and listings, of claims in this
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`application. The following amendments do not constitute an admission regarding the
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`patentability of the amended subject matter and should not be so construed. Applicant reserves
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`the right to pursue the subject matter of the canceled claims in this or any other appropriate
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`patent application.
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`Claims:
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`wherein a variation in amount between each type of nucleic acid in the plurality of nucleic acids
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`is less than 50%, wherein each of the nucleic acids comprises at least one barcode sequencefor
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`identification of each of said nucleic acids, wherein each of the at least 1000 genes comprisesat
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`least one intron, and wherein each ofthe nucleic acids is at least 0.5 kb in length.
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`2.
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`3.
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`Cancelled.
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`(Original) The nucleic acid cDNA library of claim 1, wherein each ofthe nucleic
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`acids is isolated.
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`4.
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`(Original) The nucleic acid cDNA library of claim 1, wherein each ofthe nucleic
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`acidsis purified.
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`5.
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`(Currently Amended) The nucleic acid cDNAlibrary of claim 1, wherein the
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`plurality of nucleic acids encode cDNA sequencesforat least 10,000 genes.
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`6.
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`(Currently Amended) The nucleic acid cDNA library of claim 1, wherein the
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`plurality of nucleic acids encode cDNA sequencesforat least 100,000 genes.
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`7.
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`(Currently Amended) The nucleic acid cDNAlibrary of claim 1, wherein the
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`plurality of nucleic acids encode cDNA sequencesforat least 1,000,000 genes.
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`8.
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`9.
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`Cancelled.
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`(Currently Amended) The nucleic acid cDNAlibrary of claim 1, wherein each of
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`-2-
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`U.S. Serial No. 15/603,013
`Response to Final Office Action dated November7, 2018
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`the nucleic acidsis at least 1 kb in length.
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`Attorney Docket No. 44854-701.402
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`10.
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`(Currently Amended) The nucleic acid cDNAlibrary of claim 1, wherein each of
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`the nucleic acidsis at least 3 kb in length.
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`11.
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`12.
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`Cancelled.
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`(Original) The nucleic acid cDNAlibrary of claim 1, wherein the plurality of
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`nucleic acids are attached to a structure.
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`13.
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`(Original) The nucleic acid cDNA library of claim 12, wherein the structure is a
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`solid support.
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`14.
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`22.
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`-21. Cancelled.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 1, wherein the at
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`least one barcode sequence comprises up to 50 basesin length.
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`23.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 1, wherein each of
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`the nucleic acids comprises more than one barcode sequence.
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`24.
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`(New) The nucleic acid cDNAlibrary of claim 1, wherein each of the nucleic
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`acids encodes cDNA sequencecorrespondingto one ofthe at least 1000 genes.
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`25.
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`(New) The nucleic acid cDNA library of claim 1, wherein the variation in
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`amount between each type of nucleic acid in the plurality of nucleic acids is less than 40%.
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`26.
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`(New) The nucleic acid cDNAlibrary of claim 1, wherein the variation in
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`amount between each type of nucleic acid in the plurality of nucleic acids is less than 20%.
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`27.
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`(New) The nucleic acid cDNAlibrary of claim 1, wherein the variation in
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`amount between each type of nucleic acid in the plurality of nucleic acids is less than 10%.
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`28.
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`(New) A nucleic acid cDNAlibrary comprising: at least 10,000 nucleic acids
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`encoding cDNA sequencesfor a plurality of genes, wherein a variation in an amount between
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`each type of nucleic acid in the at least 10,000 nucleic acids is less than 50%, wherein each gene
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`of the plurality of genes comprises at least one intron, and wherein each ofthe at least 10,000
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`nucleic acids comprises up to 200 nucleotides in length.
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`29.—(New) The nucleic acid cDNA library of claim 28, wherein the at least 10,000
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`nucleic acids encode cDNA sequencesforat least 50 genes.
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`30.
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`(New) The nucleic acid cDNAlibrary of claim 28, wherein the nucleic acid
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`cDNAlibrary comprisesat least 100,000 of the nucleic acids.
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`31.
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`(New) The nucleic acid cDNAlibrary of claim 28, wherein each of theat least
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`10,000 nucleic acids is 80 to 200 nucleotides in length.
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`-3-
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`U.S. Serial No. 15/603,013
`Response to Final Office Action dated November7, 2018
`
`Attorney Docket No. 44854-701.402
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`32.
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`(New) The nucleic acid cDNAlibrary of claim 28, wherein a subsetofthe at least
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`10,000 nucleic acids when assembled encodesfor one of the genes.
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`33.|(New) The nucleic acid cDNAlibrary of claim 28, wherein the variation in an
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`amount between each type of nucleic acid in the at least 10,000 nucleic acidsis less than 40%.
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`34.
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`(New) The nucleic acid cDNAlibrary of claim 28, wherein the variation in an
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`amount between each type of nucleic acid in the at least 10,000 nucleic acidsis less than 20%.
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`35.
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`(New) The nucleic acid cDNAlibrary of claim 28, wherein the variation in an
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`amount between each type of nucleic acid in the at least 10,000 nucleic acidsis less than 10%.
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`-A.
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