U.S. Serial No. 15/603,013
`Response to Non-Final Office Action dated July 10, 2018
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`Attorney Docket No. 44854-701.402
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`AMENDMENTSTO THE CLAIMS
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`This listing of claims will replace all prior versions, and listings, of claims in this
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`application. The following amendments do not constitute an admission regarding the
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`patentability of the amended subject matter and should not be so construed. Applicant reserves
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`the right to pursue the subject matter of the canceled claims in this or any other appropriate
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`patent application.
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`Claims:
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`1.
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`(Currently Amended) A nucleic acid cDNAlibrary comprising nucleic acids
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`synthesized based on instructions provided in a computer readable non-transient medium for
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`synthesis—wherein-the+nstructions-comprisea-tstof preselected cDNA sequences eerrespendine
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`te encoding for at least 1000 genes, wherein the nucleic acids encode cDNA sequences with an
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`aggregate error rate of less than 1 in 800 bases withoutcorrecting errors in the nucleic acids
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`compared to the preselected cDNA sequencesreceived in the instructions providedin the
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`computer readable non-transient medium, wherein each of the nucleic acids comprises at least
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`one barcode sequencefor identification of each of said nucleic acids, and wherein each of the
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`nucleic acidsis at least 0.5 kb in length.
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`2.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 1, wherein the
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`nucleic acids encode cDNA sequenceswith an aggregate error rate of less than 1 in 1000 bases
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`without correcting errors in the nucleic acids comparedto the preselected cDNA sequences
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`received in the instructions provided in the computer readable non-transient medium.
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`3.
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`(Original) The nucleic acid cDNA library of claim 1, wherein each ofthe nucleic
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`acids is isolated.
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`4.
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`(Original) The nucleic acid cDNA library of claim 1, wherein each ofthe nucleic
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`acidsis purified.
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`5.
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`(Original) The nucleic acid cDNA library of claim 1, wherein the nucleic acids
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`encode cDNA sequencesfor at least 10,000 genes.
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`6.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 1, wherein the
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`nucleic acids encode cDNA sequencesforat least 100,000 genes.
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`7.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 1, wherein the
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`nucleic acids encode cDNA sequencesforat least 1,000,000 genes.
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`-2-
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`

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`U.S. Serial No. 15/603,013
`Response to Non-Final Office Action dated July 10, 2018
`
`Attorney Docket No. 44854-701.402
`
`8.
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`9.
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`Cancelled.
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`(Original) The nucleic acid cDNA library of claim 1, wherein each nucleic acid is
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`at least 1 kb in length.
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`10.
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`(Original) The nucleic acid cDNA library of claim 1, wherein each nucleic acid is
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`at least 3 kb in length.
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`11.
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`12.
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`Cancelled.
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`(Original) The nucleic acid cDNA library of claim 1, wherein the plurality of
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`nucleic acids are attached to a structure.
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`13.
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`(Original) The nucleic acid cDNA library of claim 12, wherein the structure is a
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`solid support.
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`14.
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`17.
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`-16. Cancelled.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 1, wherein the
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`nucleic acids are synthesized by a process comprising chemical synthesis on a solid support.
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`18.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 17, wherein the
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`solid support comprises a plurality of molecules bound to the solid support at loci, and wherein
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`the plurality of molecules comprise a reactive group capable of coupling to a nucleoside.
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`19.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 17, wherein the
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`solid support is a plate.
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`20.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 17, wherein the
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`solid support comprises silicon, polypropylene, or polydimethylsiloxane (PDMS).
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`21.
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`(Previously Presented) The nucleic acid cDNAlibrary of claim 1, wherein each of
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`the at least 1000 genes comprisesat least one intron.
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`22.
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`(New) The nucleic acid cDNAlibrary of claim 1, wherein the at least one barcode
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`sequence comprises up to 50 basesin length.
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`23.
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`(New) The nucleic acid cDNA library of claim 1, wherein each ofthe nucleic
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`acids comprises more than one barcode sequence.
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`-3-
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