9/29/2018
`
`Espacenet - Bibliographic data
`
`
`
`A as.‘ti“Hw\\\smR\\\hHCc»HEW§USEmkw\\\\\
`
`
`
`
`
`v
`
`\k3
`35
`.5H.\suxxH
`
`‘\&s\Hwkwm
`
`\eUQm§‘\\\\H«SmV\\\h‘
`
`
`
` \\\\xUS&Hsmw
`
`K‘k
`
`an”N\
`
`it
`«¢\\m
`
`«\Nssm
`
`esxxH.#V”«is
`..t.Hax?m\\§~UAV\\H\\\\\‘
`
`x
`
`m
`
`\\Q“in
`
`at
`
`Eéxxkm&\\\kt
`
`a$5\\\
`
`At»m.“
`
`ttn“\»QR\\\a
`
`\\“
`
`..a.»
`
`xx4‘5.3“in
`
`\\h3xo.9\t..t3‘
`W3
`
`\x.
`fix3
`.‘4»
`
`wt.
`
`..
`RR§:5
`
`\\3
`
`\\3
`
`a»S.
`
`\\x«K.S‘
`
`.aQSin
`
`:_.my,
`
`it
`
`Vt.§:3m..f“N:
`..\\\
`
`itft
`
`lnventor(s)
`
`STEN LINNARSSON [SE] 5; (LINNARSSON STEN)
`
`Applicant(s)
`
`GENIZON SVENSKA AB {SE] +, (GENIZON SVENSKA AB)
`
`Classification
`
`:
`
`-In
`
`ternational
`
`Cigfii’iS/fi;
`G’SZQ’iifigfiQ
`
`Cifig’fifig; BGiJ’iQ/Gi}
`
`Application
`number
`
`- cooperative
`CN2004809714 20040209
`
`Pr
`
`IOI'I
`
`ty number(s)
`
`{33:20
`
`0300031
`
`91 200302
`
`2‘l
`
`Also publis
`
`had as
`
`GBE398301 {A}; 682308301 (§)_ {382398383 (AL
`(382398383 (EL
`
`
`
` «2..xxx.QP!igkm.a
`
`..\tt\tts
`r:.A
`
`
`\r,fix“..\v.2:
`
`..:~.huhHuh
`
`x3
`
`can
`
`M.“S
`. an
` 31?ix:rtm3.
`\«x
`R“.
`
`\3.ix
`
`
`T:
`
`\\\.e.4.
`
`a.9.
`
`misx
`t\{3w:
`
`$1“
`{xi
`
`.«u\
`
`3.:co
`
`https://worldwide.espacenet.com/publicationDetails/bibli07CC
`
`CN&NR=1771336A&KC=A&FT=D&ND=3&date=
`
`20060510&DB=
`
`&Iocale
`
`=en
`
`EP
`
`‘l/‘l
`
`
`
`
`
`
`
`
`
`
`Espacenet - Bibliographic data
`
`
`
`A as.‘ti“Hw\\\smR\\\hHCc»HEW§USEmkw\\\\\
`
`
`
`
`
`v
`
`\k3
`35
`.5H.\suxxH
`
`‘\&s\Hwkwm
`
`\eUQm§‘\\\\H«SmV\\\h‘
`
`
`
` \\\\xUS&Hsmw
`
`K‘k
`
`an”N\
`
`it
`«¢\\m
`
`«\Nssm
`
`esxxH.#V”«is
`..t.Hax?m\\§~UAV\\H\\\\\‘
`
`x
`
`m
`
`\\Q“in
`
`at
`
`Eéxxkm&\\\kt
`
`a$5\\\
`
`At»m.“
`
`ttn“\»QR\\\a
`
`\\“
`
`..a.»
`
`xx4‘5.3“in
`
`\\h3xo.9\t..t3‘
`W3
`
`\x.
`fix3
`.‘4»
`
`wt.
`
`..
`RR§:5
`
`\\3
`
`\\3
`
`a»S.
`
`\\x«K.S‘
`
`.aQSin
`
`:_.my,
`
`it
`
`Vt.§:3m..f“N:
`..\\\
`
`itft
`
`lnventor(s)
`
`STEN LINNARSSON [SE] 5; (LINNARSSON STEN)
`
`Applicant(s)
`
`GENIZON SVENSKA AB {SE] +, (GENIZON SVENSKA AB)
`
`Classification
`
`:
`
`-In
`
`ternational
`
`Cigfii’iS/fi;
`G’SZQ’iifigfiQ
`
`Cifig’fifig; BGiJ’iQ/Gi}
`
`Application
`number
`
`- cooperative
`CN2004809714 20040209
`
`Pr
`
`IOI'I
`
`ty number(s)
`
`{33:20
`
`0300031
`
`91 200302
`
`2‘l
`
`Also publis
`
`had as
`
`GBE398301 {A}; 682308301 (§)_ {382398383 (AL
`(382398383 (EL
`
`
`
` «2..xxx.QP!igkm.a
`
`..\tt\tts
`r:.A
`
`
`\r,fix“..\v.2:
`
`..:~.huhHuh
`
`x3
`
`can
`
`M.“S
`. an
` 31?ix:rtm3.
`\«x
`R“.
`
`\3.ix
`
`
`T:
`
`\\\.e.4.
`
`a.9.
`
`misx
`t\{3w:
`
`$1“
`{xi
`
`.«u\
`
`3.:co
`
`https://worldwide.espacenet.com/publicationDetails/bibli07CC
`
`CN&NR=1771336A&KC=A&FT=D&ND=3&date=
`
`20060510&DB=
`
`&Iocale
`
`=en
`
`EP
`
`‘l/‘l
`
`
`
`
`
`
`
`
`
`
`[19] Ellifikfia'i‘iflllfiifliflfh‘flfi
`
`[51] Int. C1.
`
`0120 1/68 2006. 01 )
`
`3
`
`mjfim§fl$fifi%fim¥
`
`[21] $1??? 200480009714. 3
`
`[43] QJFEI
`
`2006 £|35 E 10 El
`
`[11] QJT-E CN 1771336A
`
`
`[74] "Eifilfifimm CF lz’éflfifsfl @235) FEE/3%
`
`REA %Hfi
`
`ififl
`
`[22] Eli? El 2004. 2. 9
`
`[21] EFIiE-Fg 200480009714. 3
`
`[30] 111396711
`
`[32] 2003. 2.12 [33] GB [31] 0303191.1
`
`[32] 2003. 2.12 [33] US [31] 60/446,553
`
`[86] Emma; PCT/IB2004/000803 2004.2.9
`
`[s7] Ema/ME W02004/072294 3%“ 2004. 8. 26
`
`[85] EAElgfififiEfiElfifl 2005.10.11
`
`[711$ifijk fiflfififiifiiffl’iifi/Afi
`
`26th 2332226333ng
`
`[72] wax S ' M2012
`
`fliflfiflé—JFW fl 1313593433 36 E WEE! 3 E
`
`
`[54] 1x23543161
`
`m$$ifiiflflf¥tfih¥£$nifi
`[57] 3%;
`
`
`20352392222203. Efififififigfiéflmfilfi
`
`E¥FT+EW€fim$Z$fiBfiéEJZ ”E? fififlifiifl'fi
`
`
`#iEI‘EngEFfiIfiEfififififzfififfjéiufifiufl‘fikfl
`
`éfl‘zféfitlj, HE 53%Zflflfifzfiéfitfifilfllfilfiffié
`
`$Zfi‘fiz‘2fi?l~‘f$§$§éo
`
`flufifizfifiélfllfiflfiéfififiifi
`
`@Hfifififltwmiflk umu¢3A3u3&%$,
`
`fliifiiéfliflflflfifiéifilfllfiJi‘ZfiEl—iflfiiflo
`
`I?!
`
`FE, $%33fi%3$fl%:£fi§fiéflfiififi DNA fi¥fifl
`
`
`
`£91243, fififlfiéififlflfififififififi, EEF'FEiigfiifiEtlfi
`
`#%$D%:’fiiéfl)fi. $;¢%fi%#%$fl%:%fi)§
`
`$313} Eifl‘fliakfE EIEF'Ffiiifi Hgfifigfifi
`
`25% fit?) 3’
`in? fi'fiFEJZE
`
`
`E’i—EZEfi'ZBfiETJifi: fig]? Ifihifiififinifi fifl’]
`
`ifi'fififlZFfifiifi: %EI’J 5’
`
`5’ i”, Mfififli DNA fi?¥§ififlfi%fl’fl 5’ 323’
`
`
`
`%1/7,DLI
`at” g * :FE
`*R
`200480009714. 3
`
`
`1.mifififififlfi¢ifiifififi&%f%,%Kfi%@%:
`
`(i) fifiaéfi—fiéwflfi, Ffiflfififiaéfifififi, JAUPLa
`
`Ffiiifiv—ééiikéfizfifiéfififié 3’ififbifi‘iflffifi7fifiéfiflfifi
`
`5
`
`fiw,fiififififififififififiéfi,fifififififlfififl%%fi
`
`%&$Afliflffi§fifififififi+¥fl%;
`
`(ii) 92%—£H&Q*4\3L§4‘fifi, vXflEfiifififiifiéflfl/l‘
`
`i§¢&%,fififiwflwfififi§4&fifiéifi,afifiifif
`
`fififififi$&fiw&fih%fifii%mififiwfififlfiififlfl
`
`m fifl,
`
`fiq’“4\fififlfiz
`
`(a) EfifiTiifl‘f:
`
`@%%’%%fi&,fiifivfiaéfifififi,
`
`5m¢afififiwfiafi&xwfifififififiyfi.fi
`
`w
`
`fifififififififiéfi;
`
`fififia*fi\fifi.;fiamfifi%&iflfi%flwfi%fi,
`
`mifl “I" it: Ffiizliibififié‘fi%fiffifi%fifififiiififi%d§2\id £11}?
`flfififififififi?rfi+&*fimi&%&iififi%fiifi%m
`im%u®Mfl%fifi&fiWfi£T%&fififiéfifififififi%$
`
`m Aflfi&%+.flfié’fifl%fiiflfififlfl,mifi%&#fi%
`fifimewraflwifi-(AL Hamivim)‘ Mfififi(T)fiv%%%(G)z—i
`
`# w
`
`fl
`
`i};
`
`3
`
`)%%fii%ifikfifi%fi;
`
`fl¢fiwflfiaw
`fifififlmEWfifi%fiiflfiiflfifi%fin%fl%?flffi
`
`fifififidfi ti. #1 $2M
`fi£y#+fi%¢,fififiafifiafi.&fiflfi‘ifiimfi
`
`w fi%&i%fl%fl%fl%fi,fiflfififlffififififififl%$A,
`
`fii?’fifi%fiiflfl§fl¢%H%&m%%kfliflffifififi
`
`éfififiifi‘l’, fidfci’fiiflffifififiéfifl&fiifizfi+fififi,
`
`7T“
`
`
`
`13 %2/7Jfi;
`2%
`%E
`iFIJ
`fl
`200480009714.3
`
`
`Eiiflbfifiii"/l\fifi?$fififi?&iibfi§fl§ if"
`
`£4", %E*’I‘=‘/FK“F$E4%52§EJFfi'fi‘flfiifl‘fiéfléfifi-‘E‘fi,
`
`WJ—‘fi‘f‘ Wfiiififi%&ifif'fififl?éfifi%fi, fiifizddiibf
`
`fifififiéfifim%+, PM Viiififfififififififiéfifififiififll 641%
`
`fifiifi‘fi'fifi', fi£fi£§%m%%;
`
`(iii) $5€§£flfirifiyk
`
`fiififriiéfiiwfiiéflfiw/iiaififléfifi
`
`fiéflfié’é‘iflfifiififibflfifl;
`
`(iv) fii£9‘*£fl&%?3§)\éflEil‘ffifififiéflflfifiq’W
`
`fi$fifitfilfiéfflfii iiiaiizfiifi-‘fléfiéw’kfiawéi‘A
`
`10
`
`ifliibffifiififiéfiifififi?éfififiéfifiéfilwfifiv/iifiémfi, HF)?
`
`15
`
`20
`
`iiéfl—E—‘fiififiéi‘Aéfi’fZ—fifiéfi'kififiU/fihi.
`2.
`JFM%#X7F'J%5R 1 #:fisée, fiflpfifiéafiym, fififibflfi‘?
`$39M; aifia‘mmzigfimmawwwfifi, fififi-‘aI—fififil’fi
`
`mMfilééfi’fiifififi—fifiiihfififldaiifixwaaztfi.
`3. flififlflidk 2 66%;, afimzfiamfi’Mtfi-aw
`FfiééAfifi$fiii§fifi§fiwi fififiifi%éfl%ifiififi$2\éfifi%
`
`aiWaUfifia/éxi.
`4. *Réfififi'J—ESR 3 afiiysflz, flfifiiéfifi-fi’fififl’fiflé‘Aéfi
`
`arflfiéfii, fififiiiéfl&-%EFE$§AW#Z%&W§.
`5. #Rfifii'J—ESR 4 #1772245: fiW’E-“éfifififl: fififliflfi‘?
`fifiéf—fifiig-fi, fififil‘fififlafifi’fiaafifi.
`6.
`fifiifidvfi-a‘é 5 6417333; a%%i%*$%¢fifié§Aéfifl%
`
`fiéfid’ibfiifvi.
`7. ##Mxfidfi-sk 2 i 6 +&»Ifiéfi7‘y%,
`
`fiefiufifiv-fikfiafifi
`
`25
`
`fifiéfifififliéaifizmflfifififiia.
`8.
`#fist-ixfi'J—i—a‘a 2 i 7 fiafi-‘Jfiéfififir, fidflfifié—ifiaéfifi
`
`fifififi-‘E‘fiifififl.
`9. #E'cfiixfi'l%a‘i 1i 8 $E’Ifiéflf7‘z’e,
`
`fi-WPim‘H- A. C‘ T
`
`in G 6-6 mfififie‘ffié E1 132* flisbifififiia.
`10. #MMMQfi—i 7‘ *Xfi'l%a‘i 8 é‘dxi'mdi 9 was-~32, £+fi
`
`30
`
`%&fii£fimo
`11. #3fl-ixrf'1£‘sk 7‘ #xfli-di 8‘ bag»)? 9 imam-5K 10 64a
`
`
`
`13 %3/71fi;
`2%
`%E
`iFIJ
`fl
`200480009714.3
`
`
`in? iii-“Ffifi=§fiéAfliibffifififiéflfifi€é+w,
`
`Ffiiififi-
`
`fiwfimifi.
`
`12.
`
`JFME-ixfi'lvi-sk 7. #xfi'J§->fi 8. #Xfi'l£-21i 9 itfl£5ffi 10 #1
`
`7‘5"; £94”ifififiérfiééixédiz‘ebffifififiéfififififiiw. 23112121231;
`
`5
`
`fiéfifiialxfifriifi%&bv$léxfifii.
`
`13. #Réfiixfidi-a‘é 12 flail-5%, aiwfiilmg‘Aflifli—fifizfi
`
`fibfiflfié‘?641*4‘3‘1}+12%fib1éfilifiiiéfifiiufiiri/fifiw/fi
`
`i.
`
`14. #MDMfi-a‘i 5 E. 13 “Pfiv-Jfiéfimée, afigzev-1vm
`
`10 Wfifigfl, flfl’EiZififlifififi-éflfiflfifl, 3%”‘5‘fi‘i’fifiéififi?
`
`Di, fififi:+fi%¢fifi»fi+fi%§£.
`
`15. #Rfiixflg'tffi 14 fifiz‘ik azfimfisiawwmwaw
`
`fiaéfl, £+£&‘4\%%W, fifififififiéflfififififiififi+firfi
`
`4%éfi*fi#i¥r&£#fifil #1, %fl—Fv?fifi"‘4‘fifii+fifififi%gfififififi
`fi%;fi%+fififi%éfi-—fifi%&$flffifiwi/bfixfiéfififififi
`
`15
`
`fiéfiéfififiififi;fi¥z¢fifififiéfi*fifi%fi.
`16. gigging-1i 1 i 15 averafiéfiinfi, id’vgafiazwr
`
`a%&%—#&§fifima%y&. fifi‘ifiififfifififiéfifififi
`
`#éAfi%&.
`17.
`:rwmxfiug—sk 1 E. 16 fillfir—‘Jfiié‘lif‘iiw fl‘ilD-‘éfi‘l‘ffiififil‘
`
`20
`
`€3€$E4%*fié§.§#iFéAtfiéfiwfkdfidfi%fi,
`
`filwfik'lx’cfliflffifi
`
`25
`
`fifififififi+fifiéAfl%fi.
`18. fligixfill¥ai 1 i 17 “FEV-Ifiéfiirik, fiWfiéfififiinfi.
`ififizfifimm), fizfifiiéfii DNA fififidfiéfi DNA Rem}, fifi%
`fififlifififiaatfiiflififififiéfiaéwfiu
`19. #fizffiixfl—i—a‘i 1 i 17 “P'Hr’ifiéfifiiin fiWflfififiifli
`iflafififimM), fizfifiéérfii DNA Rifi-fifiafififimm) £124?
`ED, fififflifibfififiafifiiflfififiéfiémw.
`20. *Eéfiixi'li-SK 1 i 17 “Ffi—‘Ifiéfiifii, fii—‘i’fifififiifi
`
`30 %#Z&(RNA), fififiiééfiii—fiiifi,
`
`fizfi-‘Efij‘bfiiiifififi'iérfii
`
`ahaiiizfififiéfiaéwfiz.
`21. fifiixflfi-a‘é 1 i 20 “I’Hrv-Jfiiéfiiflk', firWfifiafifivx§
`
`
`
`fill/79L"
`13
`2%
`%%‘
`23!]
`151
`200480009714.3
`
`
`%m$%4%.
`
`22.
`
`fi%flfid%a‘i 21 967;:% afiflfifififfifififi4ané§$¥
`
`mwfifififi.
`
`23. fiégixfl£ai 22 éfiz'i% fidw‘za’yzfifiéfifi afifimvw.
`
`5
`
`24. #wang-a‘a 23 éh7‘y$%,
`
`fink-é:
`
`fi4%%§fi3&%*ivfilfi%fififlfiiéfi DNA 61‘3‘, Jifi’fifiizfiiéfixh
`fiafififiLfiflfi,fi?fifi%v%fifizfikfifi%.ififlfi
`XE-‘fi, %flaé%%%%§d%/%agzaw%a~w12a, £4”)?
`ii%*%%34€ffifriifil—fiéfi
`3’fifiiiffifiii%:.laééfi 5%,
`fifil'riifi
`10 L£F¥F4€FIT5£$L4E6§
`3’i‘éiiffl’riifi’fiié‘y 5%, Miami DNA
`fifi-fivfiififié‘: 55% 3%, J%4’*/r%%13@%filfi§fi<vfiééfialaw
`£%€~4i.§u?a-4\£r~%fi@%fi1fwlfiééglcmééfiés
`ifiifiifivfié, vxfifi§%méfiizfié¢ibfifiiiifl&fifi.
`25. #Rfiixvfll-i—a‘i 1 £— 24 *Ev-Ifififiiflh £¢fifi£1fifiw;§
`
`U £@¢%#%L.
`26. #MMMM—a‘i 25 Wfiii’: fl+§¢XEéfifi§fifiuFfirfl
`
`20
`
`25
`
`éfifléiwa‘iffilflfiiififivi.
`27. *fiififli'JE-ik 25 iflfidi—sfi 26 #17‘fl%, fiéfififififl‘m
`Jami—Elflfliiééawiéé€l%izxfiwafifim4%i#cwi.
`28. #Efiixfim-a‘i 1 i 27 ¢E*Jfiéfifi5£n amasiméuu
`iibffiéfififiéfififiié‘éqiéfifi—fifiéfififirfiv/iiififiifiiéfié}fi
`
`itifiiizfiffid.
`w.%$%fi%fi§%fifi%,fiflfifflflfififfifiAfi%
`#5., ¥é+*4‘fi%£i¥#§fi4fiififi%#§kfifi’fi$flWfi—‘Efi.
`3o. #Eifiikxfi'lofia‘i 29 2,5732%, J%+’4\9Ffifui+fififiifi¢iw
`$Aifi$flfifi%fi, Ffiiiiiafliiiaiflffi-‘ém. Hevfia'i
`(C). M%WE%(T)%E%%(G)%E%§£, fitfiffléfififihifl‘fififi
`fi'riitéé‘Aizéflfilfi-réfififiéfi.
`31. ééfiifiiii‘hxfiflfli‘Eflfl—E-a‘i 1 i 30 +Eanfig§jfigw
`
`30
`
`i+filibbkt££.
`32.
`325232121 fiME-ixflé—ai 31 éfififimfitfiéfiéfififiéfifififl
`
`T'Tiatiii.
`
`
`
`13 %5/7rfi;
`26
`5E
`iFIJ
`fl
`200480009714.3
`
`
`33. giifiikihxfliigwififififl—i—i 1 i 30 “FE—Jfiéfiir
`
`ii—dfilafiflfififitillfiv/ahfiikéfié‘gEEéfifi-fiMatgéé.
`
`34.
`
`fififilffiéfififlafi-a‘é 33 afiiJrfiiibwtfiafiéfififiéfififiém
`
`T’Tiyfifii.
`35. fiéfiz‘fifiéfiflflfi-a‘i 1 i 30 ¢&*Jfifififi%éfififidfi,
`
`5
`
`Ffiizfiifii’f'] fifi-—4\:&§ +fifid$2§+ aéa»2aéx§ £flfiibi£€éfifi
`
`5F],
`
`i?&—-éflfi£%€~éfiixfidflfi
`
`AmfiwfiififiéflWfimwfi%fi,
`£9"4\£a§é\7mkfiii——fi+\ HriiW-ivfiu ifiimfiifldfié
`flflifixwfi—fifi,flifi‘*fi2}2%&iil~fififl¢éfifi%&%é§2\
`iflifl‘ffiifififiéflfifi’éfla, fldiuifiriibffiéfififiéfiizfifiifi»
`
`fi£#,%fl
`£41, fififi/u‘fiai‘i’fifléiiaFfifiwfiiihfififléfifiafifi,
`fld*fi\ fififihifiiil‘fififl‘i’éfifi‘?fi, %#§A§U£a‘+ffi§£#fi
`fiéfififififi', fidfiiiibffizfififiéfifififififi’fifiw.
`36. mfgéiéjfiéfiixfil$di 1 i 30 “PH-’Ifiéfiir-HL—éfifléfi, a
`
`10
`
`15
`
`*3:
`
`fifi‘gfir‘ifldg‘kifi-‘ifiéfi #fiaéfi fiilfiz’ufi,
`Mffi%’+i§4\w%éfififiwafii, Afifiéflfiaiwfi
`
`20
`
`~—>}vé:4n fiafififiiiz‘ifirtfi,
`
`25
`
`Mffififiififififidéfififidh‘fitfiéfi.
`fin‘s‘ufiatfifia
`37. #EflixfiW-SK 36 #3413, fi-‘I’Jifii’fi4%,
`@fifi, fiiiéyjb 100/cm”, Hawaii 1000/cm2\ 59‘ 10 000/ch
`sigy 100 ooo/cmzéfimjfiséfififi.
`38. #Rfiixvf'J—i-ik 35 iflfi‘J—Ez‘f‘c 36 é‘J'b‘LES, fi‘i’flfiftfififil
`it)?! Téfiéfifi‘a‘téfifii: 35553433??? twill—1&5? FEi'sTfiéé‘Jii‘
`cmsfifififi\fi%afiiwfi‘fla%fiififi‘fifl%ififl
`
`Hflflfikéfifiwéflafifia‘ififii.
`39. #MMMM—a‘i 35 iflid£afi 36 954125, fiflafi‘ifiutfiifitm
`
`30
`
`ij‘bfiia.
`40. #Mfiikxvfd%>i 39 éfib‘té‘é, fiéfik‘nfiififiwfitfiifiiéflfi
`
`it.
`
`
`
`fiG/Ufi;
`13
`26
`4E
`iFIJ
`4X
`200480009714.3
`
`
`41. 4N4fififid£sk 35 i 40 444—4444545453, finiafifii‘fifim
`945443, 44454252331544 :3»me +4stlifii‘5ififiw}éafi%vfifiéfi
`
`£45m, £¢fififlififififlixfifififififii fifi4§~i4$fi€3§§ii
`iiwimfivfiifi».
`
`5
`
`42. W3¥FR$¢¥D£L$¥F£H$LD§ DNA £534, fifinfifiiizéflsxh
`
`%*%%%Lfififi.£¢fi£%*%%%;%k&fi%‘ififlfi
`
`Kfi—‘fiiJ‘lfi’Ffiiifi—“fi4‘li4c’rfifriifi—fiéfi Miz‘iffifrizfifi—ifiéfi
`
`552%,
`
`fiFfiiifif—EF-Swfi'flriifir—fiéfi B’N‘rziéffifiiifii—fiéfi 53%,
`
`Akfiv'vfifiii DNA 4}%55:7§‘$#% 44; 5’52 3’44.
`
`10
`
`43. #RéE-fibkfi'l%a‘é 42 4!; DNA 4H" ANN—434% @914] {-ififir‘
`
`#iééfié’lawééfiéu
`
`44. #Rfiixflvfi-fik 42 Shilxfl£2i 43 66 DNA h‘%, fil+*‘/I‘%+’13
`
`43%}? fmdfiéfiglaywéefiéw
`
`45. 144%4; Efiifi%ifi$fifififl%i 42‘ 412%IJ%£ 43 iii
`
`15
`
`filli-i 44 éfié/H'irs] DNA é}%éfil‘$§d, Eiiiw’u‘miafla‘é-fifilfiii
`
`14:14:46 6|%i&ki&fifi4%.
`
`46. fidéfifihfl£i 42‘ ixfl£vi 43 iiixid—i-Sii 44 #3 DNA
`
`arréfiiysab, Firiifififléé:
`
`fifiwfifi S’fi‘éifv 3’i‘r‘6fifi’fiéfififi S’i‘rfiv 3’fifiéfifi3—T—fiéfl
`
`20
`
`fi‘SLé‘JXX-fi. DNA é}%;
`
`.EL
`
`iifi-fi'éfijk, wréfgv—aééfi 3’fifiiéffiL4fiéfi 5%, 35434:?
`
`LARK Wfiffif—fi 3’Wi‘éiéffi—-%&éfi
`
`S’a‘a’é, £+Ffrii4£9<fibfii
`
`52445443.
`
`47. if§fim DNA fifiéfififi, fifiiifisiaééfifiiéixfl%i
`
`25
`
`43 iflfi'l—fi—a‘a 44 44: DNA D+9§ifififi~éffii mi}: @4244491 DNA
`
`fifiééléfivéé DNA 9%.
`
`48. ift§fim 463+ DNA fifiéfifiik, Ffrs‘iiffiifla‘fififiifiix
`
`4&4; 43 aflfi'J£—a‘é 34 #1} 4‘ DNA fiJ-Ez‘m‘fifiiffié, mi)“ 64?
`
`$4591 DNA fifiéfi§¢fi4fiwfi DNA Df.
`
`30
`
`49. 4R4E4xfid%dfi 47 SHXJF'J%-a‘i 48 #11524:- £¢i§lfia¢¥§§lefil
`
`at DNA 5}%N+%E@4$i#4w.t.
`
`50. 4R4Efifill£fii 47 Siixfl¥v§i 48 9371‘??? iiv-flf‘ébfi-ifla‘ifi’r
`
`
`
`13 %7/7Jfi;
`2%
`%E
`iFIJ
`fl
`200480009714.3
`
`
`mm DNA h“!— w §%D1 6"; DNA Riki) iiMé-‘zfil wiaxaiewyamsza
`
`£44966 DNA h\%.
`
`51. #Réfizfxfl%di 50 #374:— filfl’zéfiaé‘: DNA éw-wwzfim
`
`wifirdhi.
`
`5
`
`52. fifiixfd£i 47 E. 51 “Pfi’lfiéfiifir, ii’fiflfi‘fififi’ié
`
`449% DNA 5}“? 1*: § ##fl #1 DNA fifiéx§ 4* DNA fifififimfi» .
`
`
`
`%1/361fi;
`3F;
`HF]
`1%
`200480009714. 3
`
`
`mffifim5fif%filfl
`
`$iflfii§fimfi.$i%t%fi&“%méfifim§”
`
`5($9,%+%fi%%yfififififiQéfifi£fififlfigwfifiw
`
`fiéiiék, a‘f‘fil‘I—é’lifi—Zfiiéfi‘i, fi-‘i’fifiififiAé‘J/‘fiififi'ffi’
`
`50433. $iflfi%fié}%££ffififl4‘*fifiéfim£, afi/Lfi-fififiifiéfi
`
`“fig/£5916)? (chroma sequencing) ” +4ifi] fiFi‘IPflé‘Jfiifi—fi, Mr???
`
`ia%fim&&*m£fiw§fiflfid%m%&mfififim#fiéfi
`
`10
`
`i/PIJ’F El #fififlj’ykiéfifi-fl . 19:3in ififififuifitfififi fil‘é‘:
`
`fiat. $flififi&ifi&m ffiidéfii’réfifiifififiizfl, ukfilfifl‘lfiéfifit
`
`%%%%o$£mk%k§mfi1%wsam,aafim$afim$
`
`fiyififiéfifi‘lfié‘ififité.
`
`$5395fifififi‘iifi‘)fiRéfl‘l’iiFi—fififiiéfifif—éééfiglis?
`
`w finéflfi%@%fififififlfifi§fiflfiiwwffifififiwfi%
`
`20
`
`25
`
`fiiflfififl,mf$Afléfi%?,%fl&—fifififl%fi%mfi
`
`wfi?fi€éfi#fi%&iibifiifl, Efihifiw+ii§+iflfi+, fit-
`
`‘1’i?’Afifiafifim7téiivfizfz%fi&iilwfiéfl. fixihb 5:62.
`%fi£fi%wfifi%fifi%&iflflfifl*fiifiumf%Afléfi
`$5.4", fifi$fiflfldfififimfifl§fiiil~fié€fl.
`é‘éfiéfi'fi23-ié
`
`’4‘fiifiiéfififi-fifi‘Arfifiki, wfifi%%wfifi¥rfifli iiilflfib
`
`fifififiwfifi-fiifi. Ifii%izl‘fl&%&éfifikfifia€cifiwfifié,
`it.
`i+kiiwfifiaiifiéifififi£éflfifiwlififl#143?“ gifiwimi/u‘
`
`“%i@%&”w,flmwfixflfi%&*fifififififim%u%i
`
`£449, Wfifiéfi‘a‘fimfflfiobkiiflg-irflafiiéléfififififl004%.?“
`$€£§awmfi¢&m%§xm%fi%vafifimfi£fi¢i
`fimfiw.$ii,w%%%fifimfii@fifi,Miafifi+wfi
`753A;%fi%f517¥£ (Eflfl'lfii‘ )3Elfléa‘1fi5r‘wiilil iiiéflfr) it}?
`
`%%fi%7.Wfififi%fim5,?fifiéiflflmfifi+Wfifi£
`
`m Wflfifia#fl?fifi#%ficflARWfi#§flfifimmfiw(j
`
`fifi’éfifi’fi' mRNA #135”! ii) 6
`
`fiflflméfi&%fiiagiflfi%£%¥w3%imgam
`
`
`
`113 %2/36,DLI
`EH
`1%
`200480009714.3
`
`
`9% (epigenomics)
`
`(Eglfifl‘? Wii’f’oflfl‘fis‘fiéfiflffi - iiii’fi‘illi EVE
`
`mwmfififim&flfi%mfifififid%E%wfiWEfl5i%ww
`
`fifififlfifimfi)‘§h~§afiiwm(fififi£#&m%§%
`
`%?Wfifi%%?fifififiw5)V§flflmfiiwm(fifififi
`
`5 %颣&%%éfififiWDMfifififimfi)%%.Afi,$%%
`
`£7Fffi’céfifil f DNA fldfiéfifiiig
`
`a£meRfiwfi%wfififlfipmfifiafiufi§fl$fim
`
`§fi%.ww.%mfléfik%3mwm%flwfifimm,$wé—
`
`%mk%zmm¢fi§.aflfiTfiémEWK£$$wfl¢w
`
`10RM,£%fififl6m¢fi%fi.Emfi§$fl%wiflfifiwi%
`
`a%+,fi&%£fi%££ma$,afimfléfl%%fi%i%fifi
`
`*fififi.%%%&a+%fi§%fi§ufiififi%ioTiifi?
`
`fif&fi%%fi%fi§%—§fifi(k,$$£fifi$):
`
`
`
`
`£1|E£fi5§'1(10x1>k9<é‘3)
`
`
`
`
`fi§i%fla%(mo++¢)
`
`gag-53,
`7
`1600 Mbp
`ixfliagflfii’
`3 Gbp
`
`
`
`
`
`
`
`
`
`
`
`1+7f§é17rfliflzm
`
`400 Mbp
`
`awry” (fiEr-me J ~3oo pr
`
`15
`
`$iwfifiuié%&%%uéfifimfiim.
`
`Hfmmfléfii%
`
`fillms‘iitxxfliifiifiifiéfi Sanger all)?» (Sanger% PNAS 74 no. 12:
`
`5463-5467, 1977)ifi7‘bfsz4imafi7‘is%, amine/E 96 aka}; 384
`
`m %%%mfifl¢&%%afiw.fim,fifi%&fiffififfififi¢
`
`&§&£%k§H&W%£%E,aaxfi£fi§fifi§fiiwmfi
`
`(§flifififl$&ifi~2€fifi%fifififl).
`
`fifléfiufiflmMaafifi+fifiwfififimk§&%&fi
`
`mgfifi.
`
`10
`
`
`
`113 %3/36,DLI
`EH
`1%
`200480009714.3
`
`
`ééxhv’j‘éiéfiifl'lfifitfi] Rafa? Ffifi?$€fii-fifib—-iklfifififll
`
`(W’éfli‘frfififi I: am, in? k fiFfiffigéfiiédfikFi-idi‘fiiéfiéfié’r
`
`#Mw; 2%? 100 fiéfié’r, WM] k=10) W—éflififi, affliaarfifi
`
`$i.mfifififififififififlfii%a%flmf%ififl%mfifi
`
`5
`
`x'vffiéméwiifiyxxsmméikfifififififififiEl éfiéflé‘fikfié’, fit‘zi:
`
`fiifi 151$. HP4££X§M£E§E¢3££L flifl§%%fiéi&fi, Eli-E'-
`
`¢fififl§i¥fi¥§kfi7ffifiéfifiklfiim flfis’rdiflfi‘ififi‘ufi-fifi
`
`R].
`
`éfikéb (nanopore) ml? (US Genomics,
`
`iEJ‘ELVW 6, 355,420)
`
`10 $er Ti‘xfiéfiifii, E’Fgfiifi DNA é}%€§fi§iiéy\fi%fi)ifiiéfi%fi
`
`«TLW, fisé‘fifiéfifififiibfifiififlizrfl@%—éfi§t4bfimlfl:. iaiim
`
`Ffiifirfia k fi’éfiiéfiazfiié‘éfi DNA, fififiééfififdfil‘fiéé}? 5'1. 114%
`
`41;, fiaifithiififiéfifiwa, uifliiéfikifbififiéfifiékfifl, 5%”
`
`#Xiiffififiéfifi, fifldifié‘fiafififi/xéfiifii (30 fifi'f/wvfisla
`
`w flfiéfl).
`
`:11: aiii-l- T § fififiéfi] famemmm’» (SBS) .
`7'9 T fié'aml/itiai, wammawwm kififiifi/rfii
`é‘JéfiA,
`in, fiffifiizfiiémxfiiiéfi. iiiifiii SBS EU'J'WJ
`(gifi‘uiw Malamede% US4863849. Kumar USS908755). fi/Efivfi'ifli
`SBS #113455:
`ififimmfi/I‘ééAéfiii-‘Etfifififiikéfigdfaw,
`fixfi‘fit
`
`20
`
`mllyick'tiibl‘lfiééfii‘a‘tia.
`fifiéfimfi (DYIosequencing) (in W09323564)ifl5i#&31'1£if)h;
`EHUPPD93fiafifi+3§2x$wéfigulf-awawuzfiiafiid.
`fibTb‘Efi’
`Ffifififiéz‘%ifiéfifilfiw, fikfifimwfi'fifii, fliééAéfi$fii¢£
`% Txfimfifififl.%fi,mfifififl(&$%wfliw)fi&7m
`2E,
`lflfibXfiEfii§§3§A. WfiWfifila‘Mfix ( lflib'l‘jé‘l‘h‘fifiL
`fifiéAifififiAéfifiéfififikflfidTfi-Q‘Eéfifi-‘é‘) , flifififiifiéfi
`mm BfizfixxflJ 20—30 +65%, fiI-Eéerifli-kgwb 200,000 +L€c£§
`
`ML,
`
`30
`
`£25K Sanger m'lfififi‘4\fififi¥%%§iéfiflé§ (Wééfi'fi‘) .
`
`fifififimfififi%fifi$¢REi+fifi%fiw&£.manna
`
`fiiii' fiflvfiafilfikif‘ $K§iéfififi5¥% DNA fifi‘éfifil 5%, Ffis‘di
`
`11
`
`
`
`fill/36')?
`113
`EH
`1%
`200480009714.3
`
`
`DNA 5}%H&%fflt&%%$, Eflififimdfiafivhifififi, maxim
`
`fii‘fl‘i'f'ffi'itififi’r. REL]; fihfififiififiiiiflfl'i’l‘fifi‘fiffl (iii
`
`#u}%efi£ta )
`
`\ Rfifififivfififité MW???) o 25:76 19ml: PPi
`
`E#%%W&m%E%Z%M&m3#fi%$%%%fifi%%fii
`
`5 méfirafidficfifififififia . 1: US6274320 tin, Pselfitjififififab
`
`#9féfikifiéfifiiflifl534’ififi',Mafiffiidfifil PET-fi/ribifi-
`
`93—45-39].
`
`~Eii7‘b'fiFfié’JififififldéFfiiifléfifié‘lifiKfi/E( < 30
`
`bp). fi§fifi~§dfié£flfl£fifll§‘i’i‘f‘filififi‘fil’fil, E‘T‘fiififiéfii
`
`10 #:ikififififimit-‘fi'fifiififix-Kfiofifliififitfifi-flififfi'i
`
`éfififi,
`
`‘ig’éiéflifiiiifiy‘b 100 bp fifi‘iifixfili,
`
`US6255083 HesiTfimlfirz‘ifiiaéfifiwfifi. W001/23610 474%
`
`iiTfllfl/i’iififinfi%fi~ #Ffifl‘ll‘fifil'ibil‘tflfififfi‘mfl'flkéfifiiwfifi
`
`i.
`
`15
`
`fitfifldfiifiiéfifiifléfié‘lFfifiJéfilfiifiiéfififi‘Effifi/Efififik
`‘I’ifififsé‘fiifi.
`555v??? mfg-"iAkfififfifl‘fia FfivXWfififfivX/fi—
`lflfiifififiififlifi-fiwfimfiiffi.
`Rash-m'lfijkefiguflw, Ain‘fiT/E-fi-“iéfi‘lxéfifiia’ififiifimfl
`i‘li‘i’éfifi’é‘5WWBfi’fifll'lfifiiifilfiifio kiwi, fibfi’fi‘fi‘lfi‘fivfléfifi
`20 ml}? (fifiifihffi'fifi, mnfiszratmzmwm “ff-53:45“,
`fiiififie, «fifiifl i$iaéfifi%&%4fl%( BPfifih). 41579 $451}, Polony
`
`W11?”
`
`(Mitra RD, Church GM.
`
`, Nucleic Acids Res 1999 Dec 15; 27
`
`“In situ localized amplification and contact
`634
`(24):
`replication of many individual DNA molecules” )ifiififllfifi
`
`25
`
`30
`
`fiflufififitiiaéfiiz=§§£éfi£azfiiém
`fi—
`fiflflW%f-&*4‘Ffi3§2\éfifi%fiéfiifi=i€»fifli T fifi'l‘éfifilxfi,
`Ef%fifi%l‘%‘ itfibiki%fié$ifi*fifi¢fififiéfifi%a V139
`'F—bl‘fizfiié, thi—i—Féfil‘wfiuiiiifitigeélfififififiilz$§ifwfi=ia
`Zlfil4ifiliT*fl¥'Jii-%5Kipfifi§u Win, Polony mdffi’fifilfii‘é‘afi'fiikfiéfi
`ififi‘filfi, ££fi%&%iiififiifflfii¥;fififififi%o #RiE-{Ui
`immfisfifi, diff] Elfifi'lizu;zfi$fifi$fi7fifibJ-¥liifi%, 43511;.
`
`9‘ 99. 8%9téfifi3ewi.
`
`12
`
`
`
`113 %5/36,DLI
`EH
`1%
`200480009714.3
`
`
`awmmfifi%&fifi£i¥&fififfifififi+iififlfi
`
`Hfifii,fim%$2%@fimfififi+fimmfiwfifi%fi,fix
`
`figfifi‘&&§%Aim%ifififififl.%fi,fifiwfifl%&
`
`%%£Wflflfi(Mfifi%%fi%A$),fix%fifi%fifi&*+
`
`5 $Aag.
`
`fififlfifiafiiwfifiTfiwfififiagfimmfii%mmw
`
`%fl&£$.fififim3ufim%$¢,Wfiiififikfifififi¢
`
`¢&%.fififi%m%fii$%i%(fifififififiwimiWfifi
`
`W),A%W§$3ngm,mfiT*+éfififififié.
`
`10
`
`BASS €33:
`
`.fi%$fififififix%fl%;
`
`fimywwfimfiiifi%fi;
`
`fimfiéfi,fiki¢fi%fi;
`
`fimfifi;
`
`15
`
`. —i-F%§¢W§W, filfiuiéfiitékfififi;
`
`Cam-war—I0III
`
`iifiarm
`ifififiwfififimfixfiswmfim%fi%fi,fiflmfima
`
`&%%%(munmmwmwuwm.ifififififiiw3wmfim
`
`wa%&,£wmiww%fiwswngm(mmmw.
`
`20 W000/50642, W091/06678\ W093/05183).
`
`mfimesfiiflififiT%fiz
`.mmfimi%¢a%&,uwmfixéfififififia¢fia.
`-&d&R%Awa%&&fifim,fifiim§£%fio
`-E&#%%fi%%,%%%W%%(ifikififi%fi),u
`
`% fiT»¢%%Wfié.
`%£*,1&fiifi3ms+mmfififi$7$uim%%i:
`-€m%fi&%mwfi%Tfifl<fi+fififi%%$fifimfi
`
`%)flfii£finwfi%&.
`ofiM%fii%fifi%%Aflia%&,Mfi&&*¢%%+m
`
`w fifififlfiW@$$fi%*%fifififlfim.
`
`o?M%fi%%Ffl%#fl%%fi%&%fi§mfi.
`
`.
`
`€fn¢9fi$%fi¥%%%£lfl£afi%ifi¥rfi.
`
`13
`
`
`
`
`
`1% EH 113200480009714.3 fiS/BGJJLI
`
`
`
`
`
`
`
`fiéfi£A%%fifiBmsfififi$§fi%£&a$£$fiim
`
`#3. Nina, 1;. (Metzker 3;-
`
`“Termination of DNA synthesis by novel
`
`3’-modified-deoxyribonucleoside 5’-triphosphates” , Nucleic
`
`Adfikmlwk220m:nw%n+,mm%ws+fi+&fifi
`
`5
`
`figégmfi 3’—%a‘l‘7fléfi dUTP fin 3’-%a‘fi]&6 dCTP afifihéfi. Evfiiwfifiéa‘t
`
`#iiaffiififinéfii%“dt. Mfi%fifia%&& 3’—éa‘filéfi}lik§€itfiiaflé
`
`afiéfifififimfififiéfiefififififlimJI‘iififififiéfi.
`
`.‘é‘z, %fi€‘3§4i43~£é¢1#§~2\6fiw€~73‘5£534¢,
`
`fl'lA4nfiE‘$4‘/d%
`
`Hawfifisfifii‘fiiéfiékfifififififiéfifmfi. fimHéAéfifiaFfi
`
`m fififififii£fiflflfifififififiifiififi.Wfi,filw
`
`15
`
`m
`
`10 cm finial“ 1km“?éamés‘ééfifia‘fiwaifrlbfifkfifiugé 600
`
`000 bp/s fifimfin fir/Mfifit 60 5 (mix: 1 Nah/10 pm 965%}
`éHfi), Mrfifimsoeb/M dwa‘e fifldi, fistfifiwtifiifimm
`+¢Aéfi§lfléi i2fié9iéfifi$4v¥i5§btiafifl7er fifafifilivfi
`
`E] El iié‘J Sanger flQERQQKZF‘iE 3'3 .
`Z?— SBS “F'iifixk/i
`filfitéfigémfifiiififiéfii£4fifififz ’é‘i’t.
`tfi,m£f£kgaflwwfi¢xfim,uafizg,%i%i$
`
`vxiéfi%$&%fifié‘cfifiifiiéfifirfifiifi.
`$539312; kfi‘fiaififlufifik'rfllfifiiéfiflfi.
`
`Wfififi
`E 1 Efiiififi '3’ f'lfifi-‘fi’ifléfiififi ( fifi’fm ) Wibééklhiri
`ms, mafim‘léfiswééfififima fififlflfiéfi). firflfi'é/fifi
`fillifiv‘bafi‘ ill/551%"? (m'liééAfifiné‘Jfis’ca ) #3113: ( m'liiiéiéfi
`%i#fi%&&§§ia ) . daiififika fifiiiiiéfiliflfizék,
`’fl’daii-‘fifi
`
`25
`
`fifixfiiéfifd.
`
`a2
`EQ%MII%3%&%AMK+,fifiifi7fifi%imufi
`’é‘fi (iflifimlenow) ) ‘F’E’ifig‘k dTTP (VA C373 flit.) \ dATP 7?"
`dGTP ‘zééfisfia‘fi (HE—Win . fifiééa‘éifi/l‘a‘ézxéfi dTTP, #612
`m Efimfifim,mflfifiAgfifiT£%fifi%,m£ffifififl
`
`fiml%+%§t%%éfifi~2\.
`E 3 EflifitfiflTié/é‘fiflfldéfifikfifléafifl‘l’filflflfi filiifib]
`
`14
`
`
`
`113 %7/36,DLI
`EH
`1%
`200480009714.3
`
`
`lififififli‘éfiiviiifi iiafiifliflxtmflmm 25 x 75 mm fifivfi.
`
`xii (1)éfi1§.fii‘éfl#, Ffiififiiiw,§.#ifiimmififi. )iEz
`
`$113], fiflififl (2)4?rfi5fifiéifflfii‘. in mini: 0 (4) rhx‘iati
`
`5 (35$wa 4 ififiafiiififiéfiiiiilfimi%.
`
`5
`
`E4Efi$iiBHYiié>1£E 3%)ifii’ifilf9‘5iiéfimliéfiiifid
`
`h‘fitfiéfitéfiifiifi lo—fi‘éfiffi](1)4ififififlfifi‘35fiflzi(2)fwflifi
`
`r’é‘ (6) iiéflflfia, fli§ 2\4\ébiiid£2§ (3) figawuflrv—éeiéfi ii
`
`mIJ/ififififrfigééxrfliiiliwitiéimri. iiaa‘éii (4)7Tvl‘4il (1)"irx‘irfl
`
`macaw, Efi'ffisififiééfiifififlfi)”iéii$5nimfimtivi+fil
`
`10 mfi'id, yxm'I-fiéafiutfififiéi.
`211m iiifiififlmiiwgéfifl-iéfiimiéfi, Firiiiiwzxiix‘i
`TififiéiiiéfifiméiLWm'J/ifiii, flai4iéii§ikil$fiwii.
`
`Exiiiiif-éfififiwa», EPJ/illfi‘f'fi’ffix fifiimfiiifiéfifizx ( BMW?
`
`15
`
`kdwflufifi ) fififiTkiMXi/iéfifirfimi.
`iiiflflifiifiéfiiA-ix, EM; SBs-ii', iiifiiwimi, i
`xllEdA~5fi4¥fir4HiiL4ixt< bfififififimés‘g W01/23610 éfiifiitri
`fifitifim’fifii, i731“ BASS iflfiii‘f-Kfiléiméfiizafi-fi) .
`fix,m5fi$wfififi,Mfi+$%%#i“%i”fi%fifl
`fii‘Ffi/h 'vryxiiiaéizxfifiifii. firvxfiiwtxtfiifii. Kiwi?
`20 aixi ifirfiaiflfififiizrflfifiéfiéfrfi, F'P: 4ifi1-iir7'fliméfi7‘rfi
`(fit-“Ffi-flfi‘flfifiliiif'riéfi, fiifi$fiiflfill‘fl§£)ifwiflfimfifii
`$m-fimiimflimé§7‘rfi (Jar-“P, #62132} iiiiifii
`66‘ Jan/Ell? fili'riiil‘flfléfih‘uuiii’fiil‘ifim )
`. 131% 5: BASS
`W'Ffi‘vtifibb, 412i”)? 51%]??? iiiiiiifflfififiiifiififibiiméfifl
`
`25 Wi’i.
`ixfliafiéfinifixfififi?%ie~iéfiwii, iiifiEi-vxiii
`éfifié‘uéizdizfiétfii, fii—Aifiiifiiiiiiizxiyi’fifiifi.
`Iii/£552,643 fiifififi‘?’ *fififiiififiwiifléAmfi’iSfififii
`aiiefiafi, iifiififiifiéfiiifi/iido fiiifib xrfléfiifiiiflé‘
`w AfimfifiiwfiifiJwxmiifiiiiiigiiifiAii
`
`fiéfiafili‘éfiififi.
`fifi—flbiifiifiul’,
`
`iiifififiléfi‘x‘flfi, vxfbi’F/119’éfififi‘1’g‘A
`
`15
`
`
`
`fiS/BGDLI
`113
`EH
`1%
`200480009714.3
`
`
`Ffi’fimfifi%fi, fi-“l’iy’4‘1‘flfii/‘Lifiévxiflii—fi4flifi"T'Ffiih‘
`
`W%%&%&.ibTifi#&fiww%#.mfiafififi%fium
`
`fifiififlfifi$fifiwfifiw¢$flWiifiamfififiafiML
`
`fui$ii41$AWfifi=§fi¢éfi—-fi+(éAéfifijéfiéfig’kfiafkfiWfiif
`
`5
`
`fifiwfifififl),fi%flfiafimfimfifim%fi%fififi+ii
`
`fifi,fixwfiéflfifi+hfiaaéAmfifi%fi+fi‘fl,fim
`fififiufifiw‘m++4*%fi%.fiflih%%AmfiWfifi%
`fifii4‘fi—"fifi‘ffilfmfi,
`Ji—‘fil‘fiiéjb “4” #37713:-
`:‘zilfly‘biflfl
`fiwfi4§é§i HPEfifiifi-‘zfiéa $fliHH/EZU5] 6‘3 fifitfifi‘EP/Li‘r-QS
`m figméfimfififi%,%%fififfififl$flf“uézn%4—
`1”fi&%fi%+$Afi%fi.Mfi,EfifiW%%fi%¢,£fifl
`fld”%*fifi%+%A&%fi,w¥6fi&%%#.£%w%%
`fi$+,*flfififlfl“k¢w&naq",fififlxflmfifi,fl
`*fi’éflfififlfi%fififififii(fin “2—2—3” ). Kfii'é‘égfléaéégiifi
`w %%.%%,fifi£fi$flfiiWfi%fifififlé.
`*§%$iafléfi’/l‘7}'@, fififi’fiiifififiifiv/fifiiéflfifi
`
`20
`
`Eéfiffli— Ffiiififiieél.%:
`(i) fifi‘eaé‘firfiéfififi, Ffiiifiiééfléfifififi, £JF¢5
`Ffiiizfzfifififiv-fiifikéfififififififi S’i‘v'é/L‘ilfifl‘ffifi‘ififi
`éflfififiififi, fiimfififiifilfiéfifififiéfi, ifiiififififilmifi
`fi%%&%fi%Afliflffifififiw&fi%+iflw;
`(H)ififlflfi’¢i§¢fi%,mflifixfififififi*¢
`i§+fi%,i5%mfiw*+fi§+fififiéifi,uflfiiflf
`fifififiéfififié‘é Mfiifififiifififiififififiiéflfiiéfl #34?
`
`x &,
`
`%¢*+&%@%z
`
`(a)
`fifi-fi-‘Fiiflfi':
`fl’é‘fiflé‘ééfififi, fifififi’fifléfiéfififi,
`fififiififififiéfififififixéfigfifiéfififi 38.5%,
`
`it?
`
`30
`
`»
`fififiiififififiifi’a‘fi;
`fifififi’fi~fifi‘ififiWfifi%fiiflfl%flfifi%fi,
`VAR] '1’ tb Ffiiiizfifiéfiwfifififlflfie‘rfifififiififiwézxfl iii"?
`
`16
`
`
`
`fiQ/BGJJLI
`113
`EH
`1%
`200480009714.3
`
`
`fifififiéfififififi", fi+fi*fififififi%&£ififi%&flfl%§
`
`%m%uam%%fififififififiTfiéfififiéfififififififi$
`
`Aid DNA €624”, fififi’fififiéfiifl'fififlw, Ffriiiz=§fifivfizifi
`
`§£%m%5fi% (A) \ Hawgvim) ‘ fifififi%(T)fivfi%%¢(G)z—-i
`
`% W
`
`fl
`
`5
`
`3+;
`
`)%%ik%i$AWfi%fi;
`
`10
`
`£+£—fifi%fi
`115%in El Ffifiwfifi%fiiik'fi%fléfi&%&, a‘f-fl-fiéfifi] fifi
`
`fiifififiififiéfiéA,
`fiéw»¢fim¢,fi%fiafifi~fi\&fififi.ifiamfi
`a%&ififififlwfi%&,%flfiwmffifififimfififiéA,
`fl£9*fifi%&ififlfifl¢fifi%finfiéAfliflffifififi
`w %fi&%¢,Mh%iflffifififi%fifififi’fifiwafi
`fifififififi’¢fi%+$fififi%fiififiéfl,i%£afl
`fifim$flfi«+fifi+fi%&*fifi%&iflfiéfl;fi
`£+,%£¢¢fifi¢fi%fiamfimfiififlfiflwfi%&,
`M’fi~Wfiiififi%&iflfiéfi?fifi%fi,%$Afliflf
`m &&fififi&fifi+.Mfiiiflfgfififififififififi%fl%fi
`
`afieiiitJ—E'iéfla, fia%fifi§%méé%;
`an)fifi§£mfififi,fifififlfifififlkhfi?fifl%fi
`
`fiflfiéififiififififl;
`(u)fiiiy*flfi%+$Aflififfi&fifiwfifi%¢w
`x fi%&%flfifi¢i§.fiiflfi$ifi*flfi£¢’¢fifi¢$k
`fiiflffififififlfififi?%fi%&%fififi¢i§%flw,Mm
`fiéfl¥fifiififié§A%fi%§w'&/iivlii.
`lfififiififlfiw$i%h%fifimfifiifififik¢%fifi
`
`E.
`
`30
`
`EEfflfi (in DNA) fiat»: (if’faé‘JEidfiEfiu/fififisfléh
`fi§£m$§%)ywfiafifikfiafiflfifiy%,Wumafi’
`fifikfifl%(fi§fi%&fl%)fifi,fiu@5%*fifikfififi
`
`17
`
`
`
`filO/BGDLI
`113
`EH
`i531
`200480009714.3
`
`
`fifivéfi—fiwfifié (Ett'kfim‘F,
`
`fizzUiPJfll‘é-L %:—fiifl°§;z‘w52fz&fi
`
`fiifikéfi‘éfifi-fiifiil‘éfi?) , ifi‘fiuiaz‘iéfiéfiixfibé, EH51?
`
`Efifiliéflfiéfiififiéfifi—fiéfifihfi].
`
`fi=§fiififi¥~fi3€4wwfimfl-fiififiafi-fifiix. Alfiiz‘rH-i
`
`5
`
`fibi¥~fié§2xéfiFfififi%fifia%&%m%fiy+mfiffifiéfifi%fi
`
`iibfiéfl, iiifkfléfia%%%$Aéfi%§é+fiarfifiéfifi%&i
`
`#b'tififl, iibfkfiflmfi'fifififi‘AbfiflFfififfivi=§éfi2fz=waii+
`
`'Iiééfl fiiibfkfiflflfifiivfiéAéfiflFfi/gffiafi$éfifi¥~aifi
`
`Iriééfifl . Mifiii=fi$iibli9€fléfiiiivi5LT fi§fifiifi=fifiié4wfia
`
`10
`
`fififiéfi%~éfi§fi€~fi€éfii§fifi)fi.
`
`iaiifilifiv’l‘lfi *fififiaflfi, )fi uiaiififififii'fiéfifie‘fiéé
`
`A,fi%£%h%%%Afi%fi.
`
`fifiiififimifiiififififi (DNA), Azaifiéfliirui DNA 42:1
`
`fifiéfi DNA fi’éélfi, fiiz¥rfifivxifliiizfiiz%fififli§ifi$§fi¥r
`
`15 aim».
`
`fififififiuifliififififi (DNA) , fizfifiééfirWVX£ DNA 4R
`
`fifl$fififi§mwfiéfi,fifi%fifim£$fifi%&ifififi
`
`%&%M%.
`afifififiuifizfifiéfimm), fififiéfifiufififi-ifi,
`
`20 awatwmimiafifigfiaafiafiwéwww
`fififli'fié’l‘fi‘fiéfifififiifiiffi? £WifififléAflfl’7fi’
`
`$Ifiéfi$§§fiéfi+f¥wfimWfi%§iiiélfi>fifi%&.
`Eixfli'vélé/I‘fiifiéfi’JE—Efiiiifiififi’, fié¢fififl4xixéézx
`:5 flfiifiéfla W’fi'éfiiflfiifiifififi] 96#2%&£5i EJ #wmzratama
`
`25
`
`4.5952.
`
`E%%%%f%¢,Wfim%fififi%fififim%,fii+flk
`
`Ffiifi—fifiifififlfifi.
`$£%%%fl%fl%&?fifiw,flfimfiafiififin.$fl
`
`wig§§£ (in: A\ CA G 7%: T wiibfififl‘zl‘filflfifi) ‘I‘hxfléfifiia
`
`iTfiEi‘JZifél/ifiééfiziflfifitfiia.
`30 *fiia, Mia,
`lfiFfififlfi‘JfiFfi, $ififl$§4§é7£§m€~fiéfimfifiim imam
`
`g—waxraJ-T- 4 3L 1—1—1—1 Afififiéézdz—‘Héi.
`
`18
`
`
`
`13 Efill/BGJI
`W3
`HE
`200480009714.3
`
`
`Afi,fifiéAfifi?£hfi%fififiA2kfi3kfi%fi,x
`
`é,»&£%%%fifiu%%i$Awfi%fizé,Exmwfia
`
`é,fiéAffififififiwéAz+fi%fial+fi%fi.Wfififi
`
`fiéflé‘iéfl’é‘, uéflk‘ééfiifiifi.
`
`5
`
`fifi,£Kfi$fifififlmfifimfifii,fiflfi¢fi+fififi
`
`$Wéfi,WMffimMfiwyfiifififififi&%fi%fiéA.
`
`fifi+¥%$$?,$£flfi$7fi#%fi%,%afiw¢fi%
`
`fififiifiaflafifimmfifi,£¢5fifmufifiPW%—fifi
`
`Kéfizfifi (infikgltfia) ébfifig 3’§r%}L‘ilf-’$‘$LEZ‘+T DNA may;
`
`10Dmfi»fig“fi¢fifiéfifiéfiT~E%fi%&ékfliflffi
`
`fififlkfiifi§fiT, fifm»£flfi=iaéfifi%&( 733:7“: “fisAHZE-Efi),
`¥:$£%%S§:v1 Fa—i-z‘iéé‘AéfiiZ-B’lfifi, fifififizfi¢fifiéfiéfiéfi
`T‘ngfl%%%fi%fifiAflfifififiéfiTa$m%;fifi%
`%#Z%&(
`“£51k.” fig‘éfi) , %fi%%%V1%%*3§Aéfifi%fi,
`
`15
`
`fi-ifiig‘Afizsaifiéfifiia. iiéflfififiiififr'fi%éfifififi>k§ig
`&fififi“fi%?%i%Afi%fifififi(flfikfi).b%fi
`Xfl'FFflfi—Yrfiéfifiiaififlzfi-w, fl'lfi—W‘éé‘Aéfifiifiififi'éééfififil
`
`(flanfi) %%43v15fii.
`aifififi,Wifi$ifimmfifiwiféAfi%fiwfiEfi
`
`m flwé&.a£%%fifiwDMEw,fiiz
`0 'ET'fil‘Fl’f’Ffbfi-xg (signature) 55'], %5 EJfivélJ DNA Ei'lifl:
`
`fibbm‘;
`- flaw/r (ia'i’fl) iifififififdfifiéfiffifréfiifififibi'fi’éfi DNA
`
`%
`
`fim<wx+&»fimm&%%#>.
`fifiwfiifififi,u&é&wm%,fiflfi&flfimdec
`#VdG’f’FfibééAfiv‘ET-firfi’fifi] dTfifibfikia‘eré’rfizfifififiafi‘fikfiflfli
`
`$M%m.ww,mmsz
`
`dT [1A,2C,1G,1T3-[2A,2C,lG,3T]—[2A,2C,1G,1T]—[OA,1C,OG,1T}
`
`£+,%%¢%&$%$TfifixmmdriflflfiAfiAfi%&%
`w $i,w&fi£#m&£fim%%fi#,%mifififlfiwfi.
`
`£+¢DM§m%@Fififi%,mwz
`
`19
`
`
`
`
`
`HE W3200480009714.3 13 Efil2/36fii
`
`
`
`
`
`ACCGTGCACATTTACAGCTCT
`
`CAGCTCCAAGTTTCACGATCT
`
`%
`
`Tifi%7fi§§l)\ (base—calling) $38», fi’fiifi Ibwfiiifi
`
`éfiffilfia‘sfikfifififitfil mfifii§fi¢éfifififi4¢fib£§mfif23§§Mfifi
`
`fiéfifi.&fie&vxwzfi%$fii&&éfi§d.
`
`5
`
`xiv-Irfi‘fia, Ali/‘iwavcziéfiifiiyfififitfi'iifiéfizfii (ii
`
`I) ,
`
`fiéluié:
`
`1. %$%fififi%&fi wamzx DNA 4%, vX’f’EibfilfiWfl’f’Ffilo
`
`2. fifln’éfl”fifi§fi+fiiaéfifi%fi (#5:)? “fizvkz‘zfiétfi” )
`
`,
`
`fiakbizhéé'fam, MEifi’fiiiH—fifiéfifijéfi ($3299 “fikifi-‘Er
`
`10
`
`£5.” )flfilfi$¢£i§éfifiifi2%fimh 3%, fimfiafifigfifiziaéfi
`
`afiiz‘zfiéfifi (fimfikfiififiéfiy‘bfiliaigfi) .
`
`3. flaw, fifiu*fii§fifimfi¥rfifi($fflffiiafiifilfi).
`
`fi§££ “éauhfiziéfi” .
`
`921450 é’fi—S 3’—o—43~¢sz%§&, fiqufi
`
`‘FF‘Wibéififiiéfia‘sfil.
`
`éiflfiéa‘aa‘g‘F 3’—0H,
`
`ifiLfi-wfifi, EPICJF
`
`w fi%&%m%ifi%&.
`
`20
`
`25
`
`4. {flash iisrba‘fiéfiwfialiééAéfiwr’fidfidfi-fifi(Xflffiia
`
`12%fivaéa‘fi] wiggw,
`€1nfiryx£é$wmfififiiifiiwh£miz$
`fiéfl‘?fifi‘iil‘fiwéfifififiiiéfifi‘ffifiAéfififil . $450631? 5’-xx—
`xvi—magma 5’-(a—B-£W£):B$§&#z%&.
`5. 553%?fifiéfi£%fifi%&ififléflikfiééfi%fiTifif.
`
`6.
`
`7.
`
`fiE—z-ikéé‘AéMZfié-Eéi.
`
`PM
`imfi'ifi‘P/Fg’é 3 ‘l’izfiflaTEfiéa‘miZ—Efi,
`a.
`Fir>%-§H’fl—9MJ\
`fluifiiiz‘békfifig‘i‘ fifiéfibéukafilifi.
`b. 4mm, fifikafififikfiflfifiéé§AfiFfiméfifi§$
`
`SREXRéJ-‘Mz—‘Efiwufiugafiwouzww‘ w093/21340).
`8. Sismfiléé‘éfifi%fi£( “fikflzfi-‘Efi” )
`,
`'E’Mifififi‘kfifif
`fifi¢fiFfififi¥r&£§SK$/Jufiflwwfidbfrfiéfi, fiiififiéfi ( a‘HFo‘A‘
`afiiivfilfiz 5 43%;}3151 )E%fia%&ifim;flikfiéfi%fiflfifi. 1‘31
`%i#fi%&fi'fifi%fiiffi=i&,
`fiv/éki. yaw] Hm: BASS dualsfi) .
`
`20
`
`
`
`
`
`i531 EH 113200480009714.3 filB/BGDLI
`
`
`
`
`
`
`
`9.%%i$A%fi%&.
`
`m.&mfi*+fim&%&%#E%AWi
`
`u.Efifi,$£Mifimfiflirfimgmafigkfi,m
`
`#,i£fimfifi%%a.
`
`5
`
`H.E§$%%u,fi£mfififififififlfifi.
`
`fibfiifil‘lfiififfifii—ifi’é‘ffilflfiflifi-éflb, 53%il‘ilfibJI—fi—EfigJ
`
`fisX£E%€fi%7%fififlfififi%.fiffififlflfififilfi
`
`%#fl%§figfififiifix.
`
`Afifisfis+mfim%$%&fififi%ia%&Jafifimfi
`
`w fifisme(fifififimfiflfixfifi)%é%fiflfiiifi%.
`
`fifl%mfi%&£?fiim.M#,#%Rfiafi%1£fifimm,
`
`mafiififl%&+wfi*fififimfifi%ifi%&.
`
`fl%fififi§iflfi5fififik,%T%$%y%,£ififlfi
`
`fifimfiflwnmfiéfifififimmfi%fi.iwfifimfi%#.fl
`fiT%fifififimfimufi%w~éfifii&p,fi%fifitfigfi
`
`w
`
`Wfi$ B’ifiax’awéfififil '3'— EJ figlfifiirfii‘i.
`
`fig:“fi%%”%%fi§£fifiafi%fifimfi%aafimfi
`
`ifim%%%%%%.M#,fi%%dflPfiufififiifiififlfl
`dTTP, ii‘é‘éfib‘i‘fiifléfi dTTP arufiflakfiia dTTP Wifi5%#1. fiiaia
`
`m ifiwwifimfiiafi+aiwiwz
`- fifi£%fi%uiflfifié~%%éfi%%. Edits, fiPerkinElmer
`
`ScanArray J:., 2.5 éfifiitéféfi/iifii%ffié%fl<$éfifi%.
`ofl£§éifi%fi%%%%£,ufi£§%%%%§%fi
`(MM,£3fi’fifii%fifififi’fifl.FHTMfifiEWfiK
`
`E fifififi,fifikkfl%&fifififl%fifiuii%%.
`-E£§+%%%%%%wfi%,MEfiWHmémfiéfi%A
`
`fi?&(%fi%&kkfii%%fl§flfififififi>.
`'Wfififlfififi,AWWfifififififi%fififimf%iifi
`%,ww,fiflfiflfimwifiiaaia%&,fififi%fimif
`
`30
`
`3’—0H LESL—fiél‘h‘ii. R-fi—fiiaéfiizfiatwux$éfi3$§5§§£é§wb¥wa\,
`
`mm%¢m%fififi%%fikfifiii%%»fiflfiéffifi®fia
`
`%&£fi%%%flwfiwfl&fifi%kfifiéfli.
`
`21
`
`
`
`filli/BGDLI
`113
`EH
`i531
`200480009714.3
`
`
`ifiAiflifilfiiw~Lm&£&%fi%fi%&fiifiw
`
`fifim(£Tiififl).mfifififiumwéwwlwm+$K§
`
`5%m,wwffi¢%Awfi%fi,fifififififi£925+iik
`
`iFI-(EP, fiPerkinElmer ScanArrai, %—fi——~/l\fififlégifl, ml]
`
`5 %f%%$$1M%kfl.fifi£¢¢$fi%fi%¢éATW¢fi%
`
`&, E‘Hfitl‘flfifiv‘T‘fiJfib 1000 $153923, flfiTfiififiéfiflflfi-fifi.
`
`fififiwfififiififii+,fifil(#fl$%)h%7%fifi
`
`fiefi%#%%%%3wsfifi.wfifiAfl%&flfifififiififi
`
`W,flfi%ifi%fififlfififlfi%m,MWE¥+ifi+Wfifle
`
`10
`
`#fififlnfififimfi‘l’fiigrfi, figéfiiifififibiétfiwéafi. W‘Kmfii‘vfifi
`
`mfi¥rfififiwfififi%filfi£éfifiéfi,
`
`ifi‘fi‘ufltmififléfifié‘fi,
`
`fifi’fifi‘? fimifiaéfifizxfi%&, Ina/11%L—rj-gfiq: fifméj-pflgfigfi
`ifi%fim%fififififiiwéfii#fifflfi%fifi&fi%Afi%
`
`iififiiflfiikf
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ Charge
Still Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site
