`European
`Pate nt Office
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`Europfiiscms
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`Siii‘berfv‘é't‘ipée"
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`EP 2 749 259 A1
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`EUROPEAN PATENT APPLICATION
`published in accordance with Art. 153(4) EPC
`
`(43) Date of publication:
`02.07.2014 Bulletin 2014/27
`
`(51)
`
`Int Cl.:
`A61F 7I00 (200601)
`
`(21) Application number: 128249802
`
`(86) International application number:
`PCT/CN2012I080446
`
`(22) Date of filing: 22.08.2012
`
`International publication number:
`WO 2013/026393 (28.02.2013 Gazette 2013/09)
`
`
`(87)
`
`(84) Designated Contracting States:
`AL AT BE BG CH CY CZ DE DK EE ES FI FR GB
`GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO
`PL PT RO RS SE SI SK SM TR
`
`(72)
`
`Inventor: CHEN, Defeng
`Guangzhou
`Guangdong 510000 (CN)
`
`(30) Priority: 23.08.2011 CN 201110251389
`
`(74) Representative: Delorme, Nicolas et al
`Cabinet Germain & Maureau
`BP 6153
`
`(71) Applicant: Guangzhou Beco Electronic
`Technology Co., Ltd
`Guangzhou, Guangdong 510000 (CN)
`
`
`69466 Lyon Cedex 06 (FR)
`
`(54)
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`FAT-REDUCTION WEIGHT-LOSS METHOD AND WEIGHT-LOSS INSTRUMENT USING SAME
`
`Afat—reduction weight—loss method, comprising:
`(57)
`firstly, locally heating a site in need offat-reduction under
`37 to 60°C until the blood and muscles separate from the
`fat; then, locally freezing the site in need of fat-reduction
`under -10 to 5°C until the fat solidifies. Also disclosed is
`
`a weight-loss instrument using the fat-reduction weight-
`loss method, comprising: an input unit (A) for receiving
`a user operation and outputting a signal representing the
`user operation to a control unit (B); a control unit (B) for
`outputting a heating signal or a freezing signal to a heat-
`ing and freezing unit (C) according to the received signal
`representing the user operation; and a heating and freez—
`ing unit (C) for receiving the heating signal or freezing
`signal of the control unit (B) and conducting the heating
`or freezing operation. The fat-reduction weight-loss
`method at first locally heats the site in need of fat-reduc-
`tion to separate the blood and muscles from the fat at
`the site in need of fat-reduction, then instantaneously
`freezes the site in need of fat-reduction to solidify the fat,
`thus avoiding the harms such as tissue necrosis and the
`like caused bythe solidification of the blood and muscles
`together with the fat in thefreezing fat-reduction process.
`
`
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`Cl»
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`EP2749259A1
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`Printed by Jouve, 75001 PARIS (FR)
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`EP 2 749 259 A1
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`Description
`
`FIELD OF THE INVENTION
`
`[0001] The present invention relates to a fat-reduction
`method for removing body fat and a weight-loss appara-
`tus using the same.
`
`BACKGROUND OF THE INVENTION
`
`[0002] Chinese invention patent No. 2007800142034
`and No. 2007800000090 respectively discloses a cools—
`culpting device designed to effect a fat reduction. All of
`these devices take a merit from such a basic principle
`that the triglyceride in adipose will solidifies at 5°C. Thus,
`by sending cooling wave onto the site in need of fat-re-
`duction through a non-invasive therapeutic device, the
`triglyceride can be solidified through freezing. Because
`solidification of the triglyceride can result in it’s prema-
`turely aging, which cause the triglyceride be mildly
`cleansed and excreted through normal metabolism, the
`fat layer can be reduced and thereby a local fat reduction
`is effected. However, such a fat reduction method has
`some drawbacks which are mainly as follows: on one
`hand, the heavy—degree frostbite ofskin epidermal tissue
`will occur if the skin is under an environment of 5°C for
`
`a long time; on the other hand, because majority of the
`fat in the blood vessel is in fusion with the blood and even
`
`much of fat are surroundingly attached to the blood ves-
`sels, the blood vessels are prone to be simultaneously
`frozen to solidify during freezing of the fat, which will se-
`riously damage the human body.
`[0003]
`To overcome one of the above drawbacks of
`easily producing the frostbite of epidermal tissue in the
`current coolsculpting fat reduction technique, Chinese
`invention
`patent
`No.200780000012.2
`and
`No.200780001010.5 respectively discloses an antifreez—
`ing agent configured to be applied in coolsculpting fat
`reduction. The usage of such antifreezing agent can re-
`duce effectively the frostbite of skin epidermal tissue.
`However, it still can not solve the problem of simultane-
`ous solidification of the blood vessels and the fat.
`
`SUMMARY OF THE INVENTION
`
`[0004] An object of the invention is to provide a fat-
`reduction weight-loss method capable of avoiding frost-
`bite of tissues, such as vascular tissue and skin tissue.
`[0005] A further object of the invention is to provide a
`weight loss apparatus applying said fat-reduction weight-
`loss method.
`
`[0006] According to one aspect of the invention, it pro-
`vides a fat-reduction weight-loss method, comprising:
`firstly, locally heating a site in need offat—reduction under
`37 °C to 60 °C until the blood and muscles separate with
`the fat; then, locally freezing the site in need of fat-reduc-
`tion under -10°C to 5 °C until the fat solidifies.
`
`[0007] According to the fat-reduction weight-loss
`
`method of the invention, the local heating to the site in
`need of fat—reduction could accelerate blood circulation
`at the site in need of fat-reduction and induce the blood
`
`and the muscles to separate with thefat. Then, the instant
`freezing to the site in need of fat-reduction could induce
`solidification ofthe fat so as to avoid injure oftissue death
`damage caused by the simultaneous solidification of the
`blood and the muscles during the coolsculpting of the fat.
`The solidified fat will prematurely age and be absorbed
`or excreted through human metabolism. A microscope
`can be used for observing the separation of the blood
`and the muscles with the fat as well as solidification of
`the fat.
`
`In some embodiments, after locally heating a
`[0008]
`the site in need of fat-reduction under 37 °C to 60 °C, a
`pause may be taken for about 1 minute followed by locally
`freezing the site in need of fat-reduction under -10°C to
`5 °C . The pause results in slightly decreasing epidermal
`temperature of human body and performing buffer func-
`tion for the follow-up instant freezing.
`[0009]
`In some embodiments, a step of applying anti-
`freezing agent or laying an antifreezing film onto the site
`in need of fat-reduction may be perform ed prior to locally
`heating the site in need of fat—reduction under 37 °C to
`60 oC. The antifreezing agent could be classified into
`freezing point reduction type and surfactants type. The
`freezing point reduction type antifreezing agent includes
`low-carbon alcohols, diatomic alcohols (polypropylene
`glycol and polyethylene glycol) and amide, etc. The sur-
`factants type antifreezing agent, which brings the mate-
`rialforming a hydrophobic absorbing layer on the surface,
`generally includes acid amine salt of phosphate,
`alkylamine, fatty acid amide, organic acid ester, alkyl suc-
`cimide, etc. This results in protecting the epidermis of
`human body from heating or freezing damage.
`[0010]
`In some embodiments, sucking the site in need
`of fat—reduction to form wrinkles, or alternatively, firstly
`applying antifreezing agent or laying an antifreezing film
`onto the site in need of fat-reduction and then sucking
`the site in need of fat-reduction to form wrinkles are per-
`formed before locally heating the site in need of fat-re-
`duction. This results in blocking the blood circulation be-
`tween the site in need of fat-reduction and other regions
`of human body, which allows limiting the heating and the
`freezing only on the site in need offat-reduction. Thereby
`it decreases heating/freezing time and enhancing the fat-
`reducing effect.
`[0011]
`In some embodiments, the locally heating time
`may be 5 ~ 40 minutes and locally freezing time may be
`40 ~ 120 minutes. Generally, temperature and time of
`locally heating and locally freezing are set up according
`to the environment temperature and thickness of the fat
`layer.
`[0012] According to another aspect of the invention, it
`provides a weight-loss apparatus applying said fat-re-
`duction weight-loss method. The apparatus comprises
`an input unit, a control unit and a heating/freezing unit,
`in which,
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`the input unit is configured to receive the user’s op—
`eration and output a signal representing the user’s
`operation to the control unit;
`
`the control unit is configured to output a heating sig-
`nal or a freezing signal to the heating/freezing unit
`according to the received signal representing the us-
`er’s operation;
`
`the heating/freezing unit is configured to receive the
`heating signal ofthe control unit to conduct the heat-
`ing operation, or alternatively to receive the freezing
`signal to conduct the freezing operation.
`
`[0013] The weight-loss apparatus of the invention al-
`lows a complete separation of blood and fat by heating
`the skin and avoids injure oftissue death damage caused
`by the simultaneous solidification of the blood during the
`coolsculpting of the fat.
`[0014]
`In some embodiments, the weight-loss appara-
`tus further includes a mainframe and a working head.
`The input unit is disposed on the surface of the working
`head. The control unit is disposed inside the mainframe
`and the working head. The heating/freezing unit is dis—
`posed in the working head. The working head hasa cavity
`provided with an opening at the lower end thereof and
`an air tap at the upper end thereof. The air tap is con-
`nected to a negative pressure pump disposed in the
`mainframe through an air pipe. The opening of the cavity
`bears against the skin. A motor in the mainframe drives
`the negative pressure pump to suck the skin close to the
`cavity into the inner space of the cavity. This results in
`blocking the blood circulation between the site in need
`of fat-reduction and other regions of human body, which
`allows limiting the heating and the freezing only on the
`site in need of fat—reduction. Thereby it decreases heat—
`ing/freezing time and enhancing the fat—reducing effect.
`[0015]
`In some embodiments, the heating/freezing unit
`may be disposed at the left and right side of the cavity of
`the working head. This results in a uniform heating or
`freezing atthe site in need offat-reduction so as to protect
`the skin from damage caused by concentrated heating.
`[0016]
`In some embodiments, the working head may
`be provided with a handle. This results in facilitating of
`user operation.
`[0017]
`In some embodiments, the control unit may be
`a microcomputer and the heating/freezing unit may be a
`semiconductor cooler. The semiconductor cooler in—
`
`cludes a heat end designed to heat the skin and a cold
`end designed to cool the skin. The semiconductor cooler
`arranged in the cavity of the working head makes the
`weight-loss apparatus safe and environmental friendly
`because the cooler does not have a sliding part and any
`contamination freezing agents.
`[0018]
`In some embodiments, a radiator is provided at
`the back ofthe semiconductor cooler and the mainframe
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`is provided with therein a radiating water tank having a
`water inlet and a water outlet connected with a water
`
`pipe. The water pipe coils round atthe back ofthe radiator
`and the radiating water tank is provided with a water
`pump therein such that water in the radiating water tank
`and in the water pipe creates a circulation circuit. The
`water in the radiating water tank out of the water outlet
`flows through the water pipe and absorbs heat of the
`radiator. Then it transfers the heat to the air through the
`pipe at the water inlet and lastly flows into the radiating
`water tank. The radiator is mainly used for decreasing
`the heat of the heat end of the semiconductor cooler and
`
`thereby decreasing the cold end temperature to achieve
`the refrigeration. This results in accelerating of the cool—
`ing rate ofthe semiconductor cooler and allows it to reach
`a lower temperature.
`[0019]
`In some embodiments, the cavity may be made
`from silica gel or soft materials. As a result, the cavity
`can be tightly against the human skin without interspac-
`es, which favors the suction of the skin into the cavity.
`[0020]
`In some embodiments, the cavity may be trans-
`parent. As a result, the changes of the skin in the cavity
`can be observed through the cavity so as to turn off the
`weight-loss apparatus immediately in case of unexpect-
`ed circumstances.
`
`In some embodiments, a temperature sensor
`[0021]
`may be provided in the cavity. The temperature sensor
`can be used for measuring the temperature change of
`the working area (namely, the semiconductor cooler and
`the skin). And controlling ofthe fat-reduction process can
`be achieved according to the temperature change. This
`allows avoiding heating or cooling for too long or too
`short.
`
`In some embodiments, the cavity is provided
`[0022]
`with a LED lamp on the top thereof, which comprises red
`light, green light, blue light and other different colored
`lights. The red LED light is used to increase blood oxygen
`content for the skin in the cavity and promote blood cir—
`culation and metabolism ofthe skin in the cavity so as to
`enhance the effect of the weight-loss apparatus. The
`green LED light is turned on during freezing of the skin
`to effect anti-inflam matory so as to protect effectively the
`skin epidermis from freezing damage.
`
`BRIEF DESCRIPTION OF THE DRAWINGS
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`[0023]
`
`Fig.1 is a structural principle diagram of the weight-
`loss apparatus according to one embodiment of the
`invention.
`
`Fig.2 is a structural schematic view of the weight-
`loss apparatus according to one embodiment of the
`invention.
`
`Fig.3 is a partial cross-sectional View of the working
`head in Fig.2.
`
`Fig.4 is another partial cross-sectional View of the
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`EP 2 749 259 A1
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`working head in Fig.2.
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`22.
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`Fig.5 is an exploded structural view of the working
`head in Fig.2.
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`DETAILED DESCRIPTION OF PREFERRED EMBOD-
`IMENT
`
`[0024] The present invention can be further under-
`stood with reference to the related appended drawings
`and the following exemplary embodiments.
`[0025]
`Fig.1 schematically shows a structural principle
`diagram of the weight—loss apparatus according to one
`embodiment of the invention.
`
`[0026] As shown in Fig. 1, a weight-loss apparatus
`comprises an input unit A, a control unit B and a heat-
`ing/freezing unit C,
`in which
`the input unit A is configured to receive the user’s oper-
`ation and output a signal representing the user’s opera-
`tion to the control unit B;
`the control unit B is configured to output a heating signal
`or a freezing signal to a heating/freezing unit C according
`to the received signal representing the user’s operation;
`the heating/freezing unit C is configured to receive the
`heating signal of the control unit B to conduct the heating
`operation, or alternatively to receive the freezing signal
`to conduct the freezing operation.
`[0027]
`Fig.2 schematically shows the structure of the
`weight-loss apparatus including one embodiment of the
`functional unit shown in Fig.1.
`[0028] As shown in Fig.2, a weight-loss apparatus
`comprises a mainframe 1, a working head 2 and a bour-
`don tube 3. The input unit A is provided on the surface
`of the working head 2. The control unit B is a microcom-
`puter which may be provided in the mainframe 1 and the
`working head 2. The heating/freezing unit C is provided
`in the working head 2.
`[0029] The mainframe 1 comprises a body 11 and a
`support frame 12 mounted on the body 11 and arranged
`to place the working head 2. The body 11 has a display
`screen 13 on the surface thereof and four wheels 14
`
`thereunder. The body 11 also has set up therein a neg-
`ative pressure pump, a motor for driving the negative
`pressure pump and a radiating water tank. The radiating
`water tank has a water inlet and a water outlet connected
`
`with a water pipe 28. The radiating water tank is provided
`with a water pump such that water in the radiating water
`tank and the water pipe 28 creates a circulation circuit
`when the water pump is started.
`[0030] As shown in Fig.3, Fig.4 and Fig.5, the working
`head 2 is provided with a handle 21, a main body 22 and
`a cavity 23 arranged to suck the skin. The handle 21 is
`secured to the back end ofthe body 22. The cavity 23 is
`disposed beneath the main body 22.
`[0031] The input unit A is mounted on the surface of
`the working head 2 and it is particularly an operation key-
`board 221 disposed on the surface of the main body 22.
`Moreover, the control unit B is disposed in the main body
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`[0032] The cavity 23 is a transparentobject madefrom
`silica gel or soft materials. The bottom of the cavity 23
`opens wide to form an opening 231. On the top of the
`cavity 23 is provided with a LED lamp panel 232 on which
`mounted LED light beads with different colors such as
`red, green, and blue. Inside the cavity 23 is provided with
`a temperature sensor 24.
`[0033] On the top of the cavity 23 is further provided
`with an air tap 233. An air pipe 25 is communicated at
`one end thereofwith the air tap 233 to connect the cavity
`and the air pipe 25. The other end of the air pipe 25
`passes through the main body 22 of the working head 2
`and is connected with the negative pressure pump dis—
`posed in the mainframe 1.
`[0034] The heating/freezing unit C is a semiconductor
`cooler 26 which is disposed at the left and right side of
`the cavity 23. The semiconductor cooler 26 includes a
`heatend and a cold end in which the heat and is arranged
`to heat the skin and the cold end is arranged to cool the
`skin.
`
`[0035] The semiconductor cooler 26 is provided with
`a radiator 27 at the back side thereof and a water pipe
`coils round at the back side of the radiator 27. The water
`
`pipe 28 is communicated at one end thereof with the wa—
`ter inlet of the radiating water tank in the mainframe 1
`through the main body 22 of the working head 2 and at
`the other end thereofwith the water outletofthe radiating
`water tank in the mainframe 1 through the main body 22
`of the working head 2.
`[0036] The bourdon tube 3 is connected at one end
`thereofwith the mainframe 1 and at the other end thereof
`
`with the working head 2. The air pipe 25, the water pipe
`28 and other data wires connecting the mainframe 1 and
`the working head 2 are all packaged in the bourdon tube
`3.
`
`[0037] When in operation, one first applies antifreezing
`agent or lays an antifreezing film onto the site of skin in
`need of fat-reduction. Then allow the opening 231 of the
`cavity 23 of the working head 2 to bear against the skin
`so as to form a closure space with the skin. The anti-
`freezing agent is alkylamine in this embodiment. In other
`embodiments, however, the antifreezing agent may be
`low-carbon alcohols, diatomic alcohols (polypropylene
`glycol and polyethylene glycol), amide, acid amine salt
`of phosphate, alkylamine, fatty acid amide, organic acid
`ester or alkyl succimide.
`[0038] Next, turn on the mainframe 1 and allow the
`motor to drive the negative pressure pump. At this time,
`the circulation system ofthe radiator 27 and the radiating
`water tank is shutoff. The air in the closure space formed
`between the cavity 23 and the skin is sucked out through
`the air pipe 25 by the negative pressure pump. Under
`the negative pressure, the skin is sucked into the cavity
`23 and forms wrinkles. Thus, the blood circulation be-
`tween the sucked skin and the other region of skin is cut
`off.
`
`[0039]
`
`Pressing the heating button of the operation
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`claim 3, characterized in that it comprises: firstly
`applying antifreezing agent or laying an antifreezing
`film onto the site in need of fat-reduction; sucking
`the site in need of fat-reduction to wrinkle it; locally
`heating the site in need of fat-reduction under 37 °C
`to 60 °C; taking a pause for about 1 minute; and
`then locally freezing the site in need of fat-reduction
`under -10°C to 5°C.
`
`A weight-loss apparatus applying the fat-reduction
`weight-loss method according to any of claims 1 to
`4, characterized in that it comprises a mainframe
`and aworking head connected to the mainframe, the
`working head being provided with a cavityfor sucking
`the skin, the cavity being connected via a pipe to a
`negative pressure pump arranged in the mainframe,
`a working area of semiconductor cooler being pro-
`vided at least at one side of the cavity, the working
`area of semiconductor cooler being able to provide
`heating or freezing functions according to different
`signals received, the semiconductor cooler in the
`working area having a radiator arranged on the back
`side thereof and the radiator being connected to a
`radiating water tank arranged in the mainframe, the
`working area of semiconductor cooler being able to
`heat the skin based on a heating signal inputthrough
`a control unit and to instantly freeze the skin based
`on a freezing signal input through the control unit.
`
`The weight-loss apparatus according to claim 5,
`characterized in that the cavity has LED lamps ar-
`ranged on the top thereof.
`
`The weight-loss apparatus according to claim 6,
`characterized in that the working head is provided
`with a handle.
`
`The weight-loss apparatus according to claim 7,
`characterized in that the cavity is transparent and
`made of silica gel or soft materials.
`
`The weight-loss apparatus according to claim 8,
`characterized in that the cavity is provided with a
`temperature sensor therein.
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`10.
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`The weight-loss apparatus according to claim 9,
`characterized in that the LED lamps comprises
`LED lamps with red light, green light and blue light.
`
`keyboard 221 will make the control unit B send out a
`heating signal. Atthis time, the skin is heated by the sem—
`iconductor cooler 26 and the red LED light. The temper-
`ature data in the cavity 23 is transmitted to the control
`unit by the temperature sensor 24 and then displayed on
`the display screen 13. The temperature in the cavity 23
`is controlled as 37~60°C(for exam ple 45°C). Continuous-
`ly heating of the skin accelerates the blood circulation of
`the skin in the cavity 23. Heating of the skin continues
`for 5~4O minutes (for example 10 minutes) until the blood
`and the muscles separate with the fat. Such an internal
`change situation of the skin can be detected by a device
`like B mode ultrasound device mounted in the cavity 23.
`This device transmits a signal representing the internal
`change situation of the skin to the control unit and the
`signal is displayed on the display screen 13. Thus, the
`internal change situation of the skin can be observed by
`the display screen 13 so as to facilitate judging whether
`the blood and the muscles are separated completely with
`the fat.
`
`[0040] Upon the above heating step is finished, a
`pause for about 1 minute is taken. Then, the circulation
`system ofthe radiator 27 and the radiating water tank as
`well as the LED lamp are turn on to locally freeze the site
`in need offat—reduction under—10 °C to 5°C (e.g. at 5°C)
`for 40~120min (e.g.45min) until the fat solidifies. Finally,
`the mainframe 1 is turned off to let air enter the cavity 23
`such that the skin recoveries. The whole fat-reduction
`
`process is accomplished.
`
`Claims
`
`1. A fat-reduction weight-loss method, comprising:
`
`locally heating a the site in need of fat—
`firstly,
`reduction under 37°Cto 60°C until the blood and
`
`muscles separate with the fat;
`then, locally freezing the site in need of fat-re-
`duction under-1 0°C to 5°C until the fat solidifies.
`
`2. The fat-reduction weight-loss method according to
`claim 1, characterized in that it comprises: firstly
`locally heating the site in need offat-reduction under
`37°C to 60°C; taking a pause for about 1 minute; and
`then locally freezing the site in need of fat-reduction
`under -10°C to 5°C.
`
`3. The fat—reduction weight—loss method according to
`claim 2, characterized in that it comprises: firstly
`applying antifreezing agent or laying an antifreezing
`film ontothe site in need offat-reduction; locally heat-
`ing the site in need of fat-reduction under 37°C to
`60°C; taking a pause for about 1 minute; and then
`locally freezing the site in need offat—reduction under
`-10°C to 5°C .
`
`4. The fat-reduction weight-loss method according to
`
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`Input Unit
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` Control Unit
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`—% Heating/Freezing
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`Unit
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`Fig. 1
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`EP 2 749 259 A1
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`Fig. 3
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`EP 2 749 259 A1
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`INTERNATIONAL SEARCH REPORT
`
`
`
`International application No.
`PCT/CN2012/080446
`
`A. CLASSIFICATION OF SUBJECT MATTER
`
`A61F 7/00 (2006.01) i
`According to International Patent Classification (IPC) or to both national classification and IPC
`
`B. FIELDS SEARCHED
`
`Minimum documenlation searched (classification system followed by classification symbols)
`IPC: AGIF
`)ocumentation searched other than minimum documentation to the extent that such documents are included in the fields searched
`
` Electronic data base consulted during the international search (name of data base and, where practicable, search terms used)
`
`CNABS CNTXT VEN WPI: fat removal
`
`lose weight Lipid n'ch fat cold freez+ warm heat
`
`C. DOCUVIENTS CONSIDERED TO BE RELEVANT
`
`
`
`Category“
`
`Citation of document, with indication, Where appropriate, of the relevant passages
`
`CN 102319141 A (GUANGZHOU BECO ELECTRONIC TECHNOLOGY CO.. LTD), 18
`January 2012 (18.01.2012), claims 19, description, paragraphs [0006}[0030], and figures
`1—3
`
`
`CN 2629673 Y (TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY, CHINESE
`
`ACADEMY OF SCENCES), 04 August 2004 (04.08.2004), description, page 6, line 8 to
`page 8, line 13, and figures 1—4
`CN 1642489 A (SYNERON MEDICAL LTD), 20 July 2005 (20.07.2005),
`document
`
`CN 101340870 A (ZELTIQ AESTHETICS INC), 07 January 2009 (07.01.2009), the whole
`document
`
`
`
`US 2009018623 A1 (JLN ’F’R MEDICAL INC), 15 January 2009 (15.01.2009), the whole
`document
`
`
`
`the Whole
`
`Relevant to claim No.
`
`5— 0
`
`
`
`5— 0
`
`57 0
`
`5— 0
`
`5— 0
`
`5— 0
`
`
`
`
`WO 2011091293 A1 (ZELTIQ AESTHETICS INC. et 31.), 28 July 2011 (28.07.2011), the
`whole document
`
`I] Further documents are listed in the continuation of Box C.
`
`See patent family annex.
`
`l
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`i
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`“ M
`A
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`”
`“.2
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`“0”
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`“P”
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`Spccja] categories of cited dommcflts;
`'
`.
`_
`_
`_
`document dehnlng the general state 01 the art which is not
`considered to be of particular relevance
`1“ earlier application or patent but published on or after the
`international filing date
`.
`.
`.
`,
`document Wthl’l may throw doubts on prionty elaJm(s) or
`which is cited to establish the publication date of another
`citation or other special reason (as specified)
`document referring to an oral disclosure, use. exhibition or
`other means
`document published prior to the international filing date
`but later than the priority date claimed
`Date of the actual completion of the international search
`19 November 2012 (19.11.2012)
`
`Name and mailing address of the ISA/CN:
`State Intellectual Property Office of the P. R. China
`No. 6, Xitueheng Road. Jimenqiao
`Haidian District, Beijing 100088, China
`Facsimile No.: (86-10) 62019451
`
`“T”
`
`later document published after the international filing date
`or priority date and not in conflict with the application but
`cited to understand the principle or theory underlying the
`invention
`“”X document of particular relevance; the claimed invention
`cannot be considered novel or cannot be considered to involve
`an inventive step when the document is taken alone
`document of particular relevance; the claimed invention
`cannot be considered to involve an inventive step when the
`document is combined with one or more other such
`dOCUIIIClllS. SllCll combination being ObViUUS t0 21 [3613011
`skilled in the art
`
`“Y”
`
`“Sc”
`
`document member of the same patent family
`
`Date of mailing of the international search report
`06 December 2012 (06.12.2012)
`
`Authorized officer
`
`TAN, Quan
`
`Telephone No.: (86—10) 62085611
`
`10
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`15
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`20
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`25
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`30
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`35
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`40
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`45
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`50
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`55
`
`Form PCT/IS A/210 (second sheet) (July 2009)
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`10
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`
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`EP 2 749 259 A1
`
`INTERNATIONAL SEARCH REPORT
`
`
`
`International application No.
`
`‘
`
`PCT/CN2012/080446
`
`Box No. II
`
`Observations where certain claims were found unsearchable (Continuation of item 2 of first sheet)
`
`This intemational search report has not been established in respect of certain claims under Article l7(2)(a) for the following reasons:
`
`1. E Claims Nos.: 14
`because they relate to subject matter not required to be searched by this Authority, namely:
`methods for treatment of the human or animal body by surgery (PCT Rule 39.1 (iV)).
`
`2. El Claims Nos.:
`because they relate to p arts of the international application that do not comply with the prescribed requirements to such an
`extent that no meaningful international search can be carried out, specifically:
`
`3. I] Claims Nos.:
`because they are dependent Claims and are not drafted in accordance with the second and third sentences of Rule 6.4(a).
`
`BOX No. III Observations where unity of invention is lacking (Continuation of item 3 of first sheet)
`
`This International Searching Authority found multiple inventions in this international application, as follows:
`
`[I No protest accompanied the payment of additional search fees.
`
`As all required additional search fees were timely paid by the applicant, this international search report covers all searchable
`claims.
`
`As all scarchablc claims could bc searched without cffort justifying additional fees, this Authority did not invite payment
`of additional fees.
`
`As only some of the required additional search fees were timely paid by the applicant, this international search report covers
`only those Claims for which fees were paid. specifically claims Nos.:
`
`No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted
`to the invention first mentioned in the claims: it is covered by claims Nos.:
`
`Remark on protest
`
`El
`
`The additional search fees were accompanied by the applicant’s protest and, where applicable, the
`payment of a protest fee.
`
`[I The additional search fees were accompanied by the applicant’s protest but the applicable protest fee
`was not paid within the time limit specified in the invitation.
`
`Form PCT/ISA/ZlO (continuation of first sheet (2)) (July 2009)
`
`11
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`10
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`15
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`20
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`25
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`30
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`35
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`40
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`45
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`55
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`
`EP 2 749 259 A1
`
`INTERNATIONAL SEARCH REPORT
`International application No.
`.
`.
`.
`informatlon on patent tamlly members
`PCT/CN2012/080446
`
`Publication Date
`
`Patent Family
`
`Publication Date
`
`None
`None
`W0 03079916 A1
`US 6662054 B2
`US 2003187488 A1
`
`AU 2003212641 Al
`EP 1489984 A1
`JP 2005528935 A
`EP 2286751 A1
`CN 100400009 C
`JP4452511 B2
`US 2007270925 Al
`WO 2007133839 A1
`
`INDELNP 200702622 E
`AU 2007202443 A1
`BRP10701283 A
`KR 20070117529 A
`JP 2008522791 A
`ZA 200702640 A
`CA2585136A
`EP 2029071 Al
`MXPA 07003507 A
`JP 2010533054 A
`WO 2009011708 Al
`EP 2182872 A]
`US 2011300079 Al
`
`02.10.2003
`09.12.2003
`02.10.2003
`
`08.10.2003
`29.12.2004
`29.09.2005
`23.02.2011
`09.07.2008
`21.04.2010
`22.11.2007
`22.1 1.2007
`23.11.2007
`06.12.2007
`01.04.2008
`12.12.2007
`03.07.2008
`30.07.2008
`17.11.2007
`04.03.2009
`31.08.2008
`21.10.2010
`22.01.2009
`12.05.2010
`08.12.2011
`
`
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`10
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`15
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`20
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`25
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`30
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`35
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`40
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`45
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`50
`
`55
`
`Patent Documents referred
`
`in the Report
`CN 102319141 A
`CN 2629673 Y
`CN 1642489 A
`
`18.01.2012
`04.08.2004
`20.07.2005
`
`CN 101340870A
`
`07.01.2009
`
`US 2009018623 A1
`
`15.01.2009
`
`WO 2011091293 Al
`
`28.07.2011
`
`
`
`Form PCT/IS A/210 (patent family annex) (July 2009)
`
`12
`
`
`
`REFERENCES CITED IN THE DESCRIPTION
`
`EP 2 749 259 A1
`
`This list of references cited by the applicant is for the reader’s convenience only. It does not form part of the European
`patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be
`excluded and the EPO disclaims all liability in this regard.
`
`Patent documents cited in the description
`
`-
`~
`
`CN 200780014203 [0002]
`CN 200780000009 [0002]
`
`'
`‘
`
`CN 200780000012 [0003]
`CN 200780001010 [0003]
`
`13
`
`