PATENT COGPERATEGN TREATY
`
`EST
`
`ENTERNATEONAL SEARGH REPGRT
`
`(PCT Article 18 and flutes 43 and 44)
`
`.W
`.t' tii-rt
`r
`.t'
`i'
`l‘
`‘ppmaq 8° age" 3
`° 9 mm“
`961950
`
`FQR FURTHER
`ASTEQN
`.ga;
`
`see Form PCT/ESAJ’EQO
`as well as, where applicable, item 5' below,
`
`PCTIIB20i 6/053930
`
`30 June 2016 (30—06—2916)
`
`1 July 2015 (01-07—2015)
`
`Appiicant
`
`BTL HOLDiNGS l_,ii‘\/liTED
`
`This international search report has been prepared by this international Searching Authority and is transmitted to the appiisant
`according to Articie 18‘ A copy is being transmitted to the international Bureau,
`
`This international search report consists of a total of
`
`m it is aiso accompanied by a copy of each prior art document cited in this report.
`
`i. Basis of the report
`a. With regard to the ianguage, the international search was carried out on the basis of:
`the internatienai abpiioation in the language in which it was tiled
`
`, which is the ianguage
`E a transiatioh of the international application into
`of a transiation furnished tor the purposes of international search (Ruies 12.363} anti 23.1(b))
`
`into account the rectification of an obvious mistake
`This internationai search report has been estabiishedt
`authorized by or notitied to this Authority under Rule 91 (Ruie 43.r’3!:vis(a))v
`
`With regard to any nucieotide and/or amino acid sequence disciosed in the internatiorrai appiication, see Box No. i,
`
`
`
`Certain aiaime were tcund unsearehabie {See Box No. l!)
`
`Unity of invention is tacking (see Box No iii}
`
`With regard to the titie,
`
`the text is approved as submitted by the appiicant
`
`D the text has been estabiished by this Authority to read as foliows:
`
`With regard to the abstract,
`the text is approved as submitted by the appiioant
`
`[:1
`
`h
`the text has been estebiished, according to Rule 38.2, by this Authority as it appears in Box No. iV.
`may, within one month from the ciate oi maiiihg tthis internationai search report, submit comments to
`
`e appiicant
`this Authority
`
`With regard to the drawings,
`a.
`the figure of the drawings to be pubiished with the abstract is Figure No,
`
`4A 48
`
`as suggested by the abbiicant
`as setected by this Authority, because the appiicant failed to suggest a figure
`
`as seiected by this Authority, because this figure better characterizes the invention
`none of the figures is to be pubiished with the abstract
`
`Form PC 'li-SAI210 (first sheet) (January 2015)
`
`

`

`iNTERNAfiQNALSEARCHREPQRT
`
`chat application No.
`renewals/953930
`
`Box No. it
`
`Glaservations where certain claims were found unsaarchabie (Ccntinua’ticn of item 2 of first sheet)
`
`This iriternatiohai search report has not been established in respect of certain oiaims under Article 17(2)(a) torthe following reasons:
`
`1. CE Ciairns Nos 1
`because they relate to subject rriatter not required to be searched by this Authority, namely:
`
`Claims Nos:
`because they relate to parts of the international application that do not cpmpiy with the prescribed requirements to such
`an extent that no meaningtul internationai search can he carried out, specifically:
`
`Claims Nose:
`because they are dependent ciairns and are not drafted in accordance with the second and third sentences of Ruie 6.4(a).
`
`This international Searching Authority found multiple inventions in this international application, as fciiews:
`
`see additionai
`
`sheet:
`
`As aii required additional search tees were timely paid by the applicant; this international search report covers all searchabie
`claims.
`
`As a i searchabie ciainis could be searched \ itthit eit niListitying an additional fees, this Authority did not invite payment oi
`additionai lees.
`
`As only some of the required additicriai search tees were timely paid icy the applicant, this international search report covers
`only these clairns for which tees were paid, speciiicaiiy clairns Nos:
`
`
`
`No required additional search fees were timely paid by the applicant. Consequentiy, this international search report is
`restricted to the invention first mentioned in the claims; it is covered by claims Nos:
`
`1—23
`
`Remark on Protest
`
`The additional search fees were accompanied by the appiicant‘s pretest and, where appiicahie, the
`payment of a protest fee.
`The additional search fees were accompanied by the applicant’s pretest but the applicable protest
`fee was not paid within the time iirnit specified in the invitation.
`
`IIIIIi......
`
`No protest accompanied the payment of additional search fees.
`
`Form PCTIESA1210 (continuation cl first sheet (2)) (Aprii 2005)
`
`

`

`ENTERNAHGNALSEARCHREPQRT
`
`A. CLASSEFECATECN DF SUBJECT MATTER
`
`international application his:
`
`PCTfii52f116/053939
`
`iiiv. AfitilZ/GZ
`ADD.
`
`A61N2/00
`
`According to international Patent Ciaesification (lF’C) crtc both national c'assification and lPC
`l3. FEELDS SEARCHED
`Minimum documentation searched (classification system followed by classification symbols)
`Aélh
`
`Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched
`
`Electronic data base ocnsuited during the internaticnal search (name of data base and, where practicable, search terms used)
`
`EPOelnternai, hPt Data
`
`()ategcry’
`
`Citation of document, With indication, where appropriate, of the relevant passages
`
`Relevant to claim No.
`
`3
`
`
`
`1*8,
`12—23
`
`(M0 SEUNGekEE [KR])
`NO ESSA/881255 A1
`14 October 2004 (29941191143
`abstract
`
`lines pull
`page 1,
`page 139 lines 12—14
`page 165 line 16 w page 179 line 18
`page 19;
`line 13 a page 26,
`line 16
`page 285 line 15 ~ page 30% tine 13
`page 45,
`lines 2~16; claim 24; figures
`
`NU 2815/012672 A1
`COMPANV LTD {K21}
`22 January 2915 (2815mfil—29)
`abstract
`
`(RGMAT PHARMACEUTICAL
`
`page 3,
`page 11,
`
`line 16
`line 5 w page 7,
`lines 1_3; figures
`
`Further documents are listed in the continuation of Box i3
`
` o dooL
`I
`r” g I
`"A" document defining the general state of the art which is not considered
`to be of particular relevance
`m—r,
`: earlier application or patent 'cut published on or after the international
`“ling date
`"l." document which may throw doubts on priority clairn(c‘, or which is
`cited'to establish the Wilma“ date ”l another ”Emil” or other
`special reason (as Simellied)
`”0” document referring to an oral disclosure, use, exhibition or other
`means
`"P" document published prior to the international fiiing date but later than
`the
`ionly date claimed
`Date of the actual compietion of the international search
`
`28 September 2916
`Name and maili g address of the lSA/
`European Patent Cifiice, PB 5318 Patentiaan 2
`hit. - 2280 HV Rijswijk
`l:if2’fs%“3é‘l°f§é§2
`Form PCT/ISAI210 (second sheet) (April 2005)
`
`../'....
`
`See patent family annex,
`
`
`ling date ci' priority
`"T" later (lcoument published atter the internaticna
`date and not in conflict with the application bu. .ited to understand
`the principle or theory underlying the invention
`
`considered novel or cannot be considered to involve an inventive
`"X" document of particular reievanoe; the ciaimed invention cannot be
`step when the document is taken alone
`"Y" document at particular relevance; the claimed invention cannot be
`cansidered tc invctve an inventive step when the document is
`combined With one or more other such documents. such combination
`being obVicus to a person skilted in the art
`
`"8i" document member of the same patent family
`Date of mailing of the international search report
`
`12/12/2016
`Authorized officer
`
`Rakotondraj aona,
`
`i:
`
`page 1 of 2
`
`

`

`(UNIV COLUMBEA [US];
`ND 2010/135425 A1
`PETERCHEV ANGEL VLADIMIROV {USE}
`25 November 2010 {2010wllw253
`abstract
`
`paragraaha [0007},
`[0107],
`{0121],
`
`[0065},
`[00603 _
`[0147]; figures
`
`(FINSTERWALD P MICHAEL
`NO 2008f109058 Al
`[US}) 12 September 2008 (zaaamagmlz)
`abstract
`
`[0027},
`~
`paragraphs [0025]
`[0042],
`{0044}; figures
`
`[0036} ~
`
`03 a 117 066 A (ABRAMS RICHARB STEPHEN
`[03} ET AL) 12 Septembar 2003 (2099*99u12)
`
`iine 44
`iine 55 _ ceiumn 5,
`calumn 4,
`co1umn 8, Iine 14 — coiumn 9, 1ine 15;
`figures
`
`ENTERNAHGNALSEARCHREPQRT
`
`internaiionai appiication No
`
`PCT[102016/053930
`
`C(Cominuatien). DOCUMENTS CONSIDERED TO BE RELEVANT
`
`Citatiun of daeument, with indication, where appropriate, 0f the feievant passages
`
`Reievani to claim No,
`
`
`
`Farm PCT/ISAI21CI (continuatxon of second sheet) (Aprii 2005)
`
`page 2 of 2
`
`

`

`ENTERNAHGNALSEARCHREPQRT
` internaiionai appiication No
`
`imcrmation an paiem iamiiy members
`
`Patent dacument
`cited in search report
`
`Pubiication
`date
`
`PCT/IBEGlfi/GEEQSG
`Pubiicatian
`date
`
`Patent famiiy
`mem ber{5)
`
`2993235315
`29949985412
`2996187697
`2994987255
`
`2432547
`2997549
`2912198883
`2919135425
`
`25—lfiw2994
`98—19m2994
`24*98~2996
`14wl9—2994
`
`28~93~2912
`19—98~2915
`@3_g5_2912
`
`25n11~2919
`
`99 299499?255
`
`A1
`
`14—19u2994
`
`Farm PCT/ISAI21CI (patent falmiy annex) (Apri? 2905)
`
`

`

`international Appiication No. PCT/l 132916! 953939
`
`FURTHER ENFORMATEGN CONTENUEE} Ffim’v’i
`
`PCTIESA/
`
`21(3)
`
`This internationai Searching Authority found muitipie (groups of)
`inventions in this internationai aooiication, as ioiiows:
`
`l. ciaims: 1_23
`
`A magnetic stimuiation device which produces a timewvarying
`magnetic fieid for treatment, wherein the device comprises:
`a connection to an energy source, a Switching device, a
`magnetic tieid generating device, an energy storage device;
`wherein the magnetic iieid generating device comprises
`insuiated wires; and a voitage drop in the energy storage
`device between successive ampiitndes output from the energy
`storage device is not higher than 21 h.
`
`2, ciaims: 24—33
`
`A magnetic stimuiation device producing a time—varying
`magnetic tieid for treatment, wherein the device comprisesza
`connection to an energy source, a switching device, a
`magnetic tieid generating device producing time—varying
`magnetic fieid, and an energy storage device; wherein the
`switching device is connected in oaraiiei
`to the energy
`source.
`
`
`
`3. ciaims: 34, 35
`
`A magnetic stimniation device producing a time—varying
`magnetic fieid for treatment, wherein the device enahies
`moduiation of the time—varying magnetic fieid in magnetic
`tiux density domain, repetition rate domain and/or impuise
`duration domain.
`
`4. ciaims: 35_43
`
`A magnetic stimuiation device producing a time~varying
`magnetic tieid for treatment, wherein the device comprises:a
`connection to an energy source, a switching device, a
`magnetic tieid generating device, an energy storage device;
`wherein the magnetic stimuiation device enahies treatment
`with peak to peak magnetic fidx density of at ieast 1.5 T
`and with singie magnetic guises repeated at a repetition
`rate above 50 H2,
`
`5. ciaims: 44—45
`
`A magnetic stimuiation device producing a timemvarying
`magnetic tieid for treatment, wherein the device comprisesza
`connection to an energy source, a switching device, a
`magnetic tieid generating device, an energy storage device;
`wherein the device enahies repetition rates above 109 Hz
`with a magnetic iiux density ensuring at ieast partiai
`
`

`

`FURTHER ENFORMATEGN CONTENUEE} Ffifli’v’i
`
`PCTIESA/
`
`21(3)
`
`muscie contraction.
`
`international Appiication No. PCT/l 132916! 953939
`
`6. ciaims: 47m58
`
`A magnetic stimuiation device generating time—varying
`magnetic fieid for treatment of a patientB wherein device
`comprises:an HF frequency generator, a switching deviceg a
`magnetic iieid generating device, an energy storage device;
`wherein the magnetic iieid generating device providing
`magnet treatment and radioiregnency treatment.
`
`7, ciaims: 59—74, 85, 86
`
`A magnetic stimoiation device inciuding:
`at ieast one aoniicator, at ieast one energy source, a
`pinraiity of Switching devicee, at ieast one energy storage
`device and a pioraiity of magnetic tieid generating devices,
`wherein the at ieast one switching device is eiectricaiiy
`connected in naraiiei
`to the energy source,
`
`8‘ ciaims: 75n84
`
`the same characteristic quantity.
`
`A magnetic stimoiation device incinding at ieast one
`appiicator, at ieast one energy source, a ninraiity of
`switching devicess a oioraiity of energy storage devices and
`first and Second magnetic iieid generating devices
`enehiing:generating imooises via the first magnetic fieid
`generating device; and generating impnises via the second
`magnetic fieid generating device independentiy oi the
`imnnises generated by the first magnetic fieid generating
`device.
`
`9, ciaims: 87m116
`
`A magnetic stimuiation device for treating a hioiogicai
`structure by timemvarying magnetic fieid enahiing:
`determining at ieast one vaiue of operation parameter in at
`ieast one vaine of a characteristic quantity, wherein the
`vaine of operation parameter i5 reiated with at ieast one
`oi: a) a caiihration curve, h) a caiihration vaioeg c) at
`ieest one vaine of the same operation parameter in the
`differentvaiue of the same characteristic quantity? wherein
`the caiihration curve and/or the caiihration vaiue may be
`determined in the same vaine or in the different vaine of
`
`

`

`PATENT CQQPEfiATiQN TREATY
`
`From the
`INTERNATIONAL SEARCHiNG AUTHORITY
`
`nor
`
`
`
`..
`.
`n
`Ste “3”” PC"iSA’QQO
`
`WRETTEN oernron or: THE
`ENTERNATEQNAL SEARCHENG AUTHoerTv
`
`(PCT Ruiz-’3 43bis.i)
`r7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777
`
`Date of mailing
`(day’month/yeant
`
`see form PCT/18,4210 (second sheet)
`
`FCR FURTHER ACTEGN
`Applicant's or agent's tile reference
`See paragraph 2 heiow
`SEES form PG ASA/220
`i,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,i,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
`internationat appiication No.
`internationai tiiing date (day/I'nom‘h/j/ear)
`Priority date (days/rnonth/j/eant
`30.06.2016
`01.07.2015
`
`internati
`tat Patent Cias
`:oation (i C) or both national classification and IF’C
`
`iNV. A61 NEIGQ A61 N200
`
`Aoplioant
`BTL HQLDENGS LIMITED
`
`
`
`t.
`
`This opinion contains indications rotating to the tottowing items:
`
`.. Box No.
`
`Basis otthe opinion
`
`_.i Box No.
`
`tI
`
`Priority
`
`iii
`ii Box No.
`tV
`A: Box No.
`.-.i Box No. V
`
`8 Box No. Vi
`
`Non-estabiishment of opinion with regard to noveity, inventive step and industrial appiioabiiity
`Lack of unity of invention
`Reasoned statement under Rule 48bis.t (atti) with regard to noveity, inventive step and industriai
`appiicabiiity; citations and expianations supporting such statement
`Certain documents cited
`
`Certain defects in the internationai application
`E Box No. Vii
`i3 Box No. Viii Certain observations on the internationai aoptisation
`FURTHER ACTEON
`
`2.
`
`if a demand for international preiirrrinary examination is made, this opinion wiii usuaily be considered to be a
`written opinion of the international Preiin'iinary Examining Authority i”iPEA"} except that this does not apply where
`the appiioant chooses an Authority other than this one to he the iPEA and the chosen iPEA has notited the
`International Bureau under Ruie 5-5.1bi'sib) that written opinions ,t this international Searching Authority
`wiii not he so considered.
`
`if this opinion is, as provided above, considered to be a written opinion of the ii’EA, the appiioant is invited to
`submit to the iPEA a written repiy together, where appropriate, with amendments, before the expiration of 3 months
`train the date of rnaiiing of Form PCT/ESA/QZO or before the expiration of 22 months from the priority date,
`whichever expires tater,
`
`For further options, see Form PCTASAQQO.
`
`
`
`Name and mailing address of the iSA:
`
`Date of compietion of
`this opinion
`
`i
`
`Authorized Officer
`
`@3
`
`__________________
`
`European Patent Office
`
`PB. 5818 Patenttaan 2
`NL-zzs'o HV Rijswijk - Pays Bas
`Tel, +31 76 340 - 2040
`Fax: +31 .70 340 — 3015
`
`I
`
`39f term
`PVTASAQW
`
`i Rakgtgncfiraaagna C,
`i
`I
`I
`Teiephone No. +31 70 340-0
`
`
`
`Form PC't‘rtSAQS?’ (Cover Sheet) (January 2015)
`
`

`

`WRETTEN GPENEQN QF THE
`ENTERNATEQNAL SEARCHENG AUTHQRETY
`
`internatiohei eopiioetion No.
`PCT/18291 61053930
`
`Box No. i Basis ot the opinion
`
`1. With regard to the ianguege, this opinion has been established on the basis: oi:
`
`the internetionet eopiioetion in the ianguege in which it was tied.
`
`a trensietioh oi the internetionei aopiicetion into , which is the ianguege of e transietion furnished for the
`purposes ot internetionei search (Rules 12.3(e) and 23.1 (b)).
`
`This opinion has been estebiished taking into account the rectification oi an obvious mistake authorized
`by or notified to this Authority under Ruie 91 (Ruie 43bi3.‘i (8.))
`
`With regard to any nuoieotide end/or amino acid sequence diseioeed in the internetionai apeiioation, this
`opinion has been estebiished on the beeis of a sequence iistingz
`
`E E
`
`}
`
`2.
`
`if]
`
`[3
`
`a. E iorrning part of the internetionei eopiioetion as tiieo:
`
`[I]
`
`in the form oi an Annex (3/3125 text tiie.
`
`E] on paper or in the term of an image fiie.
`
`h. E turniehed together with the internetionai epoiioatioh under PCT Ruie iBterJte) for the purposes of
`internationei search oniy in the form of an Anne): ESTES text iiie
`
`o. D furnished subsequent to the internetionei iiiing date for the purposes oi internatiohei search oniy:
`
`U in the form of en Annex 0131125 text tiie (Ruie t3ter.i(a)).
`
`[I] on paper or in the term ot an image tiie (Ruie tSter.t(b) and Administrative instructions, Section
`713).
`
`4.
`
`ii]
`
`in addition, in the case that more than one version or oooy oi a sequence iisting has been tiied or furnished.
`the required statements that the information in the subsequent or additiehai copies is identioei to that
`forming part ot the eppiioetion as tiied or doee not go beyond the epoiioation as tiieo, as appropriate, were
`furnished.
`
`5. Additionet comments:
`
`Form PC'i‘riSA/‘EB‘I (January 201 5}
`
`

`

`WRETTEN GPENEQN QF THE
`ENTERNATEQNAL SEARCHENG AUTHQRETY
`
`internationei eppiioetion No.
`PCT/@291 61053930
`
`Box No. iii Non-estehiishment oi opinion with regard in novelty, inventive step and industriei
`eppiioebiiity
`
`The questions whether the eiairned invention appears to be novel, to invoive an inventive step (to be non
`obvious), or to be industriaiiy eppiioehie have not been examined in respect oi
`
`if]
`
`Ed
`
`the entire internetionei appiicetion
`
`oieinis Nos. 24-1 i6
`
`because:
`
`if]
`
`E}
`
`Ci
`
`Xi
`
`Ci
`
`the said internetionai appiieation, or the said eiaints Nos.
`not require an internetinnei search (specify):
`
`reiete to the toiiowing subject matter which does
`
`the description, ciaims or drawings (indicate particular eiements below) or said oiaims Nos.
`that no meaningqu opinion oouid he termed (specie/i:
`
`are so unetear
`
`the eieirns, or said oiairns Nos. are so ii’iedeoneteiy supported by the description that no meaningqu opinion
`oouid he formed (specnjy):
`
`no internationei search report has been estehiiehed tor the whoie appiication or tor said cieirns Nos. 24416
`
`3 ntenningini opinion couid not he termed without the sequence iisting; the appiicnnt did not, within the
`prescribed time iimit:
`
`a furnish a sequence iisting in the form of an Annex C/STQS text iiie, and such listing was not avaiiahie
`to the internetionei Searching Authority in the form and manner eoneptebie to it; or the sequence iistihg
`furnished did not cempiy with the standard provided tor in Annex C of the Administrative instructions.
`
`5 furnish a sequence iisting on paper or in the form of an image iiie oompiying with the standard provided
`tor in Annex {3 ot the Administrative instructions. and such iisting was not avaiiehie to the internetionei
`Searching Authority in the term and manner eeeeptehie to it; or the Sequence iisting turniehed did not
`coinpiy with the standard provided tor in Annex C of the Administrative instructions,
`
`iii pay the required iate furnishing tee tor the furnishing of a sequence iisting in response to an
`invitation under Ruie tSter.t(e) or (b).
`
`Ci See Supplementei Box tor turther deteiis
`
`Form PC'i'riSA/‘EB‘I (January 201 5}
`
`

`

`WRETTEN GPENEQN QF THE
`ENTERNATEQNAL SEARCHENG AUTHQRETY
`
`internatienei appiicaiien Ne.
`PCT/1829161053930
`
`Bex Ne. EV Leek et unity of inventien
`
`1.
`
`i223
`
`in respense to the invitation (Perm PCT/ESAQOG) to pay additienei tees, the appiieant has, within the
`eppiicahte time iirnit:
`
`Ci
`
`IL]
`
`[1
`
`[Xi
`
`paid additipnei tees
`
`paid additipnai fees under protest and, where appiicebie, the pretest fee
`
`paid additipnei fees under protest but the eppiicabie pretest fee was net paid
`
`not paid additionat fees
`
`2 E] This Authority found that the requirement (if unity of invention is not eempiied with and chase not to invite
`the appiieent to pay additionai fees.
`
`3. This Authority considers that the requirement of unity of inventinn in accordance with Ruie i3.‘i, 13.2 and 13.3 :s
`
`E] compiied with
`
`ix} not compiied with for the teiiowing reesens:
`
`see segerete sheet
`
`4. Consequentiy, this report has been estabiished in respect of the iniinwing parts of the internatienai application:
`
`i] at! parts.
`
`
`the parts reiating to cieiins Nos. 1—23
`
`iXi
`
`80): Ne. V Reesened statement under Ruie 43bis.1(a}(i) with regard te nevetty, inventive step or
`industriei eppiieehitity; citations and expienetiens supperting such statement
`
`Yes: Cieims
`N0:
`Ciaims
`
`Yes: Ciaims
`Ne:
`Cieims
`
`Yes: Ciaims
`N0:
`Ciaime
`
`
`1-23
`
`
`1—23
`
`_t__2;3__
`
`1. Statement
`
`Neveity (N)
`
`inventive step (ES)
`
`industrieiappiicebiiitytiA)
`
`2. Citations and expianatiens
`
`see separate sheet
`
`Form PC'i‘xiSA/‘EB‘I (January 20'] 5}
`
`

`

`WRETTEN GPENEQN QF THE
`ENTERNATEQNAL SEARCHENG AUTHQRETY
`
`internatichai applicahhh N0.
`PCT/1332C)? 61053930
`
`Box N9. VEEE Certain observations on the Enigmatianal appiicaiion
`
`The maiowing abservations on the ciarity of the ciaims, descripticn, and drawings or on the question whether the
`ciaims are My supported by the descripiiah‘ are made:
`
`398 Segarate aheet
`
`Form PC'E/ISA/‘EB‘I (January 20'] 5}
`
`

`

`WRETTEN QPiNiflN QB: THE
`
`ENTERNATEQNAL SEARCHENG
`
`internationai appiication No.
`
`AUTHGRETY (SEPARATE SHEET)
`
`PCT/@201 6/053930
`
`i-te item it!
`
`Lack ct unity of invention
`
`Ncnuunity a posteriori
`
`The appiication ciaims 9 inventions which for reasons indicated beiovv are not so
`
`iinited as to term a singie generai inventive concept (Rate 131 PCT).
`
`The separate inventions/groups of inventions are:
`
`Subject ‘3
`
`: ciaime t—23
`
`A magnetic stimtiiation device which produces a time~varying magnetic iieid for
`
`treatment, wherein the device comprises: a connection to an energy source, a
`
`switching device, a magnetic iieid generating device, an energy storage device;
`
`wherein the magnetic tieid generating device comprises insuiated wires; and a
`
`voitage drop in the energy storage device between successive ampiitcdes output from
`
`the energy storage device is not higher than 21 %,
`
`Subject 2: ciaims 24—33
`
`A magnetic stimuiation device producing a time~varying magnetic tieid for treatment,
`
`wherein the device ccmprises:a connection to an energy source, a switching device, a
`
`magnetic tieid generating device producing time—varying magnetic tieid, and an
`
`energy storage device; wherein the switching device is connected in paraiiei to the
`
`energy source,
`
`Subject 3: ciaims 34, 35
`
`A magnetic stimniation device producing a time-varying magnetic iieid for treatment,
`
`wherein the device enaoies moduiaticn oi the time—varying magnetic tieid in magnetic
`
`tiux density domain, repetition rate domain and/or impuise duration domain.
`
`Subject 4: ciaime 36—43
`
`A magnetic stirnoiation device producing a time—varying magnetic iieid for treatment,
`
`wherein the device compriseea connection to an energy source, a switching device, a
`
`magnetic iieid generating device, an energy storage device; wherein the magnetic
`
`stimuiation device enables treatment with peak to peak magnetic iiux density of at
`
`ieast 15 T and with single magnetic pniees repeated at a repetition rate above 50 Hz,
`
`Subject 5: ciaims 44—46
`
`Form PCT/i53A/237 (Separate Sheet) (Sheet i) (EPO-Aprii 2005)
`
`

`

`WRETTEN QPiNiflN QB: THE
`
`ENTERNATEQNAL SEARCHENG
`
`internationai appiication No.
`
`AUTHGRETY (SEPARATE SHEET)
`
`PCT/38201 6/053930
`
`A magnetic stimuiation device producing a time-varying magnetic tieid for treatment,
`
`wherein the device comprisesza connection to an energy source, a switching device, a
`
`magnetic tieid generating device, an energy storage device; wherein the device
`
`enabies repetition rates above “EGG Hz with a magnetic iiux density ensuring at ieast
`
`partiai inuscie contraction.
`
`Subject 6: ciaims 4768
`
`A magnetic stimuiation device generating timenvarying magnetic tieid for treatment of
`
`a patient, wherein device compriseszan HF frequency generator, a switching device, a
`
`magnetic iieid generating device, an energy storage device; wherein the magnetic
`
`iieid generating device providing magnet treatment and radioireguency treatment.
`
`Subject ‘7: ciaims 59-74, 85, 86
`
`A magnetic stimuiation device inciuding:
`
`at ieast one appiicator, at ieast one energy source, a piuraiity of switching devices, at
`
`ieast one energy storage device and a piuraiity oi magnetic tieid generating devices,
`
`wherein the at ieast one switching device is eiectricaiiy connected in paraiiei to the
`
`energy source.
`
`Subject 8: oiaims 75—84
`
`A magnetic stimuiation device inciuding at ieast one appiicatcr, at ieast one energy
`
`source, a oiuraiity oi switching devices, a piuraiity of energy storage devices and first
`
`and second magnetic tieid generating devices enabiingzgenerating impuises via the
`
`first magnetic tieid generating device; and generating impuises via the second
`
`magnetic tieid generating device independentiy of the imouises generated by the first
`
`magnetic iieid generating device.
`
`Subject 9: ciaims 87—116
`
`A magnetic stimuiation device for treating a oioiogicai structure by time—varying
`
`magnetic iieid enacting:
`
`determining at ieast one vaiue of operation parameter in at ieast one vaiue of a
`
`characteristic quantity, wherein the vaiue ct operation parameter is reiated with at
`
`ieast one of: a) a caiibration curve, b) a caiibration vaiue, c) at ieast one vaiue oi the
`
`same operation parameter in the ditterentvaiue of the same characteristic quantity,
`
`wherein the caiibration curve and/or the caiibration vaiue may be determined in the
`
`same vaiue or in the different vaiue oi the same characteristic quantity.
`
`Form PCT/ESA/237 (Separate Sheet) (Sheet 2) (EPO—Aprii 2005)
`
`

`

`WRETTEN QPtNEQN QB: THE
`
`ENTERNATEQNAL SEARCHENG
`
`internationai appiication No.
`
`AUTHGRETY (SEPARATE SHEET)
`
`PCT/38201 6/053930
`
`According to Ruie 18.2 PCT, unity of invention is oniy provided if there is a technicai
`
`reiationship invoiving common or corresponding speciai technicai features amongst
`
`different groups of inventions.
`
`This is not the case, however, in the appiication.
`
`‘i
`
`The oniy common feature between independent ciaims ‘i, 24, 36, 44, 47, 59
`and 75 is:
`
`A magnetic stimuiation device which produces a time—varying magnetic tieid
`
`for treatment, wherein the device comprises:
`
`a connection to an energy source, a switching device, a magnetic fieid
`
`generating device, an energy storage device.
`
`This feature, however is not a speciai technicai feature in the sense of Ruie
`
`iii—2 PCT, since it is wet! known in the art, see : patent document/appiication
`
`WORM Qt 35425, paragraph 7 and figure 2A.
`
`The further features of ciaims t, 24, 36, 44, 47’, 5e and 75 are aii different and
`
`aiso cieariy not corresponding because they soive different objective
`
`probiems.
`
`- ciairn t : to achieve higher repetition rates of magnetic puises and higher
`
`magnetic fiux density for treatment of the patient.
`
`-- oiairn 24: to reduce eiectric energy tosses and improve efficiency white
`
`generating time—varying magnetic fieid,
`
`— ciaim 36: to stimuiate bioiogicai tissue nonuinvasiveiv (to cause at ieast
`
`partiai muscie contraction repetitiveiy).
`
`- ciaim 44: to stimuia‘te bioiogicai structure for diagnosis, prognosis or for
`
`improving the patients weii~being
`
`- ciaim 47: to provide various treatments at the same time eg. treatment for
`
`ceiiuiite, adipose tissue and biood fiow improvement.
`
`— ciaims 59, 69, 85: to provide faster treatment and to treat different reas in
`
`shorter time and to stimuiate different areas and/or target bioiogicai structures
`at the same time.
`
`— ciaim 3’5: to muitipiy the repetition rate oi impuises perceived by the patient
`
`aiiowing treatments with ”high repetition rates" with sufficient cooiihg and/or to
`
`provide various treatments by different magnetic fieid generating devices. the
`
`various treatments providing various etfects for the patient, eg. stimuiation,
`
`pain aiieviation or myoreiaxation.
`
`Form PCT/ESSA/EB? (Separate Sheet) (Sheet 3) (EPO-April 2005)
`
`

`

`WRETTEN QPtNEQN QB: THE
`
`ENTERNATEQNAL SEARCHENG
`
`internationai appiieaticn Ne.
`
`AUTHGRETY (SEPARATE SHEET)
`
`PCT/38201 6/053930
`
`2
`
`Furthermcre, the eniy common feature between independent cieime 34, 87
`
`and ciaime 1,24,36,44,47,59,end 75 is:
`
`A magnetic etimuiaticn device which predecee a time-varying magnetic fieid
`fer treatment.
`
`This feature, however is net a speciai technicei feature in the eenee ei Ruie
`
`tit—2 PCT, since it is weii kncwn in the art, eee : patent docurnent/eppiicatien
`
`W02010135425, paragraph 7 and figure 2A.
`
`The further features cf eiaime t, 24, 36, 44, 47, 59, 75 and cieims 34 and 87
`
`are eii different and etec ctearty net cerreepcnciing because they ecive
`
`different Objective prehiems as ‘ieiiews.
`
`— Ciairn fzte achieve higher repetitien rates of magnetic puiees and higher
`
`magnetic ‘iiux density for treatment of the patient.
`
`— Ciaim 34: te previcie an aneigesic effect for alievia‘iing pain.
`
`— Cieim 87: to prctect the patient and/or the magnetic etimuietien device from
`
`heat damage.
`
`Fer the prehieme eeived by cieirne 24, 36, 44, 47, 59, and 75, refer to peint 1
`above.
`
`Hence, there are he cemmcn er cerreepending eeeciei technicet feature in the sense
`
`of Ruie 13-2 PCT in independent ciairne ’i, 24, 34, 35,44,417, 59, 75 end 87 and
`
`therefore, the eppiicatien techs unity in the sense of Ftuie ts—t PCT.
`
`Re item V
`
`Reeeeneci etetement with regard te neveity, inventive step er indeetriet
`
`eppiicehiiity; citetiene and expienetiene Supperting ench statement
`
`3
`
`Reference is made to the feiiewing documents:
`
`[if WC) 2004/G87255 At (MO SELENG—KEE [KRD t4 October 2004 (290440—14)
`
`i232 WC) 2015/6125??? At (ROMAT PHARMACEUTiCAL CQMPANY LTD [K29 29
`
`January 2015 (201501—29)
`
`D3 WO 2010/135425 A‘i (UNiV COLUMBEA {US}; PETERCHEV ANGEL
`
`VLADEMEROV {USE} 25 Nevember 2010 (2010—1 i~25)
`
`e5 us 6 H7 cee A (neenrrrs HECHARD ereenen {US} ET AL) r2 September
`
`20cc (essence-12)
`
`Farm PCT/ESA/EB'i (Separate Sheet) (Sheet 4) (EPO-April 2005)
`
`

`

`WRETTEN QPtNiflN QB: THE
`
`ENTERNATEQNAL SEARCHENG
`
`international eppiicaticn Ne.
`
`AUTHGRETY (SEPARATE SHEET)
`
`PCT/38201 6/053930
`
`4
`
`Furthermcre, the tack pf ciarity mentioned in item Viii netwithstanding, the
`
`subject—matter cf eiaim “i does net inveive an inventive step in the sense of
`
`Articie 33(3) PCT. and the criteria of Articie 33(1) PCT are therefore net met.
`
`4.1
`
`[231 may be regarded as being the prier art cicsest tn the subject—matter of
`
`claim 1, and discicses:
`
`A magnetic stimuiaticn device (abstract; p. t, i. 5—‘i ii which prcdnces a time-
`
`varying magnetic tieid tcr treatment, wherein the device cemprises:
`
`a ccnnectien to an energy scurce (p. t7, i. ts-ts; fig. 2A), a switching device
`
`{145, i525), a magnetic tieid generating device (p. 23, i. 8-—t 6), an energy
`
`storage device (p. 19, i. 13 -- p. 20, i. 4; fig. 2A); wherein the magnetic fieid
`
`generating device comprises insuiated wires (impiicitiy discicsed in Di ).
`
`The subject-matter cf ciairn 1 therefore differs from this kncwn device ct Di
`that:
`
`in
`
`A): a vcitege drcp in the energy storage device between successive
`
`ampiitudes output frem the energy storage device is net higher than :2? %.
`
`The prchiem tc he scived hy the present inventicn may therefcre be regarded
`
`as to achieve higher repetition rates ct magnetic puises and higher magnetic
`
`tiux density tcr treatment of the patient.
`
`The scinticn proposed in ciaim ‘i of the present appiicaticn cahnct he
`
`ccnsidered as invciving an inventive step (Artiste 33(3) PCT) fer the teiicwing
`reascns:
`
`The feature A is merely cne of several straightforward pcssihiiities item which
`
`the shilied perscn weuid seiect, in accerdance with circumstances, witheut the
`
`exercise ct inventive skiii, in crder tc scive the prchiem posed. Mcrecver, a
`
`slight difference in amplitude between successive piiises output from a
`
`storage capicitcr is very ccmmen, in generat the difference in ampiitude
`
`shcuid be much fewer than 21 percent in a nerrnai circuit. Another pcssihle
`
`scinticn te the abcve prehiem ccuid he meduiaticn cf the signat, fer exampie,
`
`ampiitdde meduietien.
`
`4.2
`
`02 step discicses the main features ct ciairn i, incinding the essentiat tetures
`
`mentioned in item Viii Le. a magnetic flux density of atieast 1.5 Tara
`
`repetiiicn rate abet/e 50 Hz; see page 3, fine 5 in page 7, iine 16 and page
`
`it, tines t~3.
`
`Th