(12) INTERNATIQNAL APPLICATIQN FUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
`
`(19) W'nrid Inteiiectuai Propert‘y Organizatinn 4
`Intemational Bureau
`
`2?. January 20100110120153)
`
`(43) Inflternafinnai Publicafinn E31111:
`
`(10) International Pubiicatinn Number
`
`WI} 20101907614 A3
`
`('74) Aug:ent DR 1] ’AL BRESSI ER 1”,”); 11 TuV'a! St.
`52 522 Ra1n111 (32111 (H).
`
`(51) Internatinnall’atem Classificatinn:
`361W 2/130 (2006.00
`ANN 1/40 (2006.01)
`AMN 2/32 (2006.01 )
`
`(21)
`
`Internatinnal Appiicafiun Number:
`
`PCT/"ILZOO‘I/IIOOGKt-‘I
`
`(22)
`
`Internatiemal Fifling Date:
`
`29 June 2009 (29.06.2009)
`
`English
`.
`English
`
`171)
`
`I73)
`(75)
`
`(81) Designated} States (unless otherwise indicated, for may
`kind of national protection mnilable): AI}, AG, AL. AM.
`AG, AT, AU, AZ, BA, 1313,8134. BU, BR, BVV BY, BZ4
`131731.811. C1 (21', CO, CR. 3U, CZ. DE, DK, UM. DO.
`DZ, EC. EF EC}, ES, F1, (38, (3B, OF. L3H. GM. GT4.
`ILJ. HR. IIU, ID, IL, IN, IS. JP. KE, KG. KM. KN, KP.
`KR, K31 LA, LC. LK, LR, LS, LT, LU, LY. MA, MD,»
`(25} Filing Language:
`ME, MG, MK, I» N. MW. MX. MY. MZ, NA, NG, NI.
`44 4
`4’
`4
`7
`NO, NZ, ONE, p11” PG, PH. PL, PT, RO, RS. RI}, SC. 804
`:6) Pubheatlon Language:
`SI SG SK, SL, SM, ST, SV, SY, TJ, TM, TN. TR. TT.
`(30) Pl'inritV' Data:
`TZ, UA, DU, US, UZ, VC, VN, ZA, ZM, ZW.
`US
`240 June 1003 (79063008)
`61/076,652
`US (84) Designates} States (unless otherwise indicated, for eve/(1'
`If) NOVCMb‘X 2003 I G 12008)
`51/1 121783
`
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`TM). European (AT, 111:1. 1111, (311,1?1',1:z, 111;, UK, 1114:.
`Inventers; and
`ES. FI, FR GB, GR, HR, HU, IE, IS, 1"“ IT, 1U, L".
`Inventersx‘Applicants for LS only): RON EDOUTE.
`MC, MR, MT. NI.., N0. 1114 PT, 12.0
`,SK "[1234
`Dried [IL/IL]; MA Josef Milo 81., 69643 Tel Aviv (IL),
`OAPI (BF. BI. CF. CG, CI. CM,11A,GN,GQ,GW MI
`RnN ETQOUTE, 0m {112/111L,] 14A .10 sef Milo 51 (19643
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`
`13‘c‘3m‘1'3I‘5 111111221 ”we 417
`— as: to applicants emit/(2.1mm 10 (1271111412 4151' and he grained
`a patent (Rule 4.1' 7(’ii))
`
`(54) Title: AN ESTHETIC APPARATUS USFFUL FOR INCREASING SKIN REJUVENATION AND METHODS THEREOF
`
`Continued 0n nextpage]
`
`/\
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`(57) Abstract: The present luvei1111111 provides a xvstem f011 11Jereasing skin rerVenation of a region Ufa patient' 3 811211101111{Mung
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`W0 2019/0976E4 A3 I'EEIEEIIIEIEIIIE'EHEIIEIIiElEIIIEJEEHll|.|EE|'[EE[.IIEEIEEI[E[J'El'
`
`.EIEIE. JIEE?.IEEE'
`
`Published;
`,
`,,
`,
`,
`.
`.. .
`wzm zmernatzmval search raga/1m? (An. 21(3)}
`befbre mg expirmian Qf‘lirc {We limit/fl)? amending the
`claims and :0 be republished in the even! ofreceipz of
`amendments (Rule 48. 202)}
`
`(88) Date 01' pubiicatim} ufl'the imematimml search report:
`61VI’m2010
`03'
`
`

`

`ENTERNAHQNALSEARCHREPGRT
`
`~
`
`H
`~~~~~~
`international appEicafinn No
`
`.......
`
`951/1L2009/090544
`
`A. CLASfiEFECATECN/()F' $128.”? 5 MATTER
`ENV.
`A61NZ/DG
`A61N1/32
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`Afilfil/éfl
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`Awarding E0 Enierna‘xionai PaEarn Classir'icarron'EPC) crEIII both natmnaE cEasciJcaEEcn and EPC
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`ReEevant 1-:- cEaEm Ne.
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`Y
`
`‘A
`
`CiEaEEa-n of dummem, I
`
`.EE1EndEcafian, where appropriate, of the relevant pagsages
`
`E
`
`BE 33 4% 974 A1 EKRAUS MERNER DEPL PHVS
`KRAUS WERNER QIPL PHYS {DEE}
`23 May 1985 (1985m65~23}
`abstraci
`
`page 4, EEne 4 w page 10, Eine 16
`
`GB 2 188 238 A (VMEI EENIN N33 EMEI LENEN
`813 [381} 39 September 1987 (1987mflgw30)
`abstract
`
`page a, paragraph 25 n paragraph 53
`
`US 2606/293719 fil {NAGHAVI MQRTEZA {333)
`28 December 2086 {2&06~12m28)
`paragraph [06483
`paragraph {@068}
`
`E,4~18
`24~28
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`2,3.
`19~23
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`
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`“T" EaEer ducumem pubEEshed afte. the E..Iemationa
`or pEEorEtjy date and n0?En conflict with Ehe app
`an but
`
`Lfled to understand {he prim;'pie or theory undériy:mg the
`Envemion
`
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`“X" documem u? p
`cannot be cc 3106er DOVE} or camot be Considered to
`
`involve an Emu-En1ve- step when'...e document is xaken alone
`document of particular relevance; the claimed invention
`rannut be ccnsEdared to Web(a an EnvenEEE/e slep- WhEm the
`documentES cuenbanad with. one m mo:6 other such men
`merits, such commnatE-ars being obvious to a person skiEEIed
`"‘me Em
`.
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`,
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`8. document .rzemb'er or the same pateni famrly
`Date of mailing of the imemafinnal search report
`
`mm
`1
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`other means
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`EaEe: than me priorEEy' date cEaimacE
`Date ofthe aciuaE compEeE'Eon of ihe internationaE search
`
`5 Navember 2009
`Name and maiEmg address D? the {SN
`EIIampaan Patent 0815:9993 5818 Pateniiaan 2
`NE. _ 228-9 HV FEE
`_E<
`TeL(+SE»70)340—EO4G,
`%x9€%flflmm€MG
`
`Form PCTI‘ Six/21o {sestand shflet) (AprII 2.785)
`
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`
`33/03/2010
`AuEhm’Ezed officer
`
`n n
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`

`

`l Reievant to ciaim No.
`
`19m22
`
`23
`
`19,21g22
`
`19~21
`
`:Y
`
`ENTERNAHQNALfiEARCHHEPQRT
`
`AL) 25 August 2005 (zasswoamza)
`abstract
`
`paragraph [9059} “ paragraph [@068]
`
`N0 93/12835 A (FREE NDRLD TRUST {US};
`DROLET ROLAND A [CA])
`8 Juiy 1993 (19§3_07“08)
`abstract; figure 2k
`
`US 2034/034346 A1 (STERN ROGER A {US} ET
`AL) 19 February 2684 (2G04uflZw19)
`abstract
`
`paragraph {$075} w paragraph [03783
`paragraph EGQBQE w paragraph [$093]
`
`INC {US}; STERN
`M0 60/53313 A (THERMAG'
`ROGER {USE} 14 September 2008 (Zflfiflmflgwld)
`abstract
`
`line 31
`page 8, Effie 29 ~ page 9,
`page 28, 1ine 26 w page 30, Eine 3
`
`9E 38 25 155 A1 (KASTL ELECTRONIC GMBH &
`CO KG [953) 25 January 1990 {1990'01-25)
`ciaim 1
`
`EB 3Q4 587 A (ABRAHAM ESAU)
`13 March 1930 (193Gw03*13}
`claim 1
`page 2,
`
`iine 37 w line 45
`
`MO 2009/047628 A (ENDYMIGN MEDECAL LTD
`{EL}; LISCHINSKY QANIEL [IL]; HARTH YGRAM
`{EL} EN) 16 Apri? 20G? (2909—94~16>
`the wh01e document
`
`Faun PCT/:3N21D (continuation of seems Sheet} (Apr)! 20%)
`
`

`

`ENTERNATEQNAL SEARCH REPORT
`
`lniemaiianai application No.
`PCT/ELZGQQ/OQQSM
`
`
`Bax Na. in Uhservations where certain ciaims were found unsaarchabie (Cflfifinuafion cf item 2 m‘ firsi sheet)
`WW
`
`This iniemaiicnai search report has mi been established in respect of ceriain claims unriar Ariicie ‘i‘i(2l(a) for ihe iollowing reasons:
`
`”a.
`
`29-55 774”
`[X 3 Claims Nos;
`“" becausa they reiate to subject malfex‘ mi. required in be searched by this Au‘l'mriiy, nameiy:
`
`Rule 39.1(ivi
`S urg any
`
`FCT m Meihod for treatment 0f the human or animai body by
`
`ya
`
`__J. Claims Nos;
`because trig-y relate to pads (21 lire iniernaiional applinalion ihai do not comply with ihe prescribed requiremem‘s to such
`an extenl lhai no meaningfui iniemationai search can be carried gut, specificaliy:
`
`3.
`
`Claims Nos;
`i
`“““ because they am dependent Ciaims and are not drafted in accarrlance with the second and third sameness of Rule 6.4(al.
`
`East No. Eli Observations where unity cf invention is lacking (Cnntinuatinn (if item 3 (3‘? first sheet)
`
`This internaticnai Searching Authority fauna! multipie inveniirariS in ihi$ iniernatianai appiicaiian, as follsws:
`
`see additionai sheet
`
`1-..."3 As ail required additimnai search fess ware timely paid by the applicantx this lntemaiienai $851th rE—pm covers all searchabie
`' claims,
`
`As all searchabie claims coul-zi be searched without effortiustiiying an additicnai fees ihls Authority did not invite fiaymem oi
`addiiirmai fees.
`
`(£1
`
`5 As only some a? the? required additional watch fees were timeiy paid by the applicant this interriaii‘cnai search report covers
`------4 aniy muse ciaima it): which fees were? paid, specifically claims. N05;
`
`4.
`
`X Na required addiiimal search fees were timely paid by the: applicant. Consequaniiy, this lnleruaiianai search report is:
`restricted to the invamimn first mentioned in the claims; it is covered by claims Nos:
`5846‘ annex
`
`Remark cm Hates:
`
`;
`
`{The addiilunai search fees were acmmparsiea' by ihe appiicam’s protest and, where applicabla, 13m
`payment 91' a pmlesi: fee.
`
`r. The addiiicnai search fees were accampaniec‘ by the applicant’s protest but the appiicabie protest
`--'-- fee was net paid within the iime iimit specified in the invitation.
`
`
`
`{No protest accompanied the paymém 01 additional search ices.
`
`
`
`

`

`This Internatiana? Searching Authority found muitipie (graups 9f)
`inventiens in this internationa] eppiicatian, as feéiows:
`
`1. ciaime: 1~28
`
`
`
`A system adapted in increase skin rejuvenatien Of a region
`of a patient’s skin,
`the system camprising a puised
`eieciramagnetic fieid (PEN?) frequency generaior and a deep
`tissue diathermy device,
`the eystem being adapted fer
`simultaneuusiy appiying heat and FEM? t0 the region of
`patient skin. The system additienaliy comprises a centre}
`system adapted ta manitor physicai
`tissue paramefierg and
`change the appfiied heefi and eiectromagnetic puises
`accerdingEy.
`
`2. ciaims: 56w76
`
`An integrated system adapted to increase Skin rejuvenation
`a? a region of a patient’s skin,
`the system camprising at
`feast two eiectrodes adapted to be p1aeed an the region 0F
`patient’s skin; each 9f the e1ectrades being at fieast
`partiaifiy ceiied via a co??; wherein each of the electrades
`is adapted for bath providing eiectromegnetic pulses to the
`region of patient’s skin and appiying heat up to temperature
`T t0 the regien 0f patient’s skin.
`
`

`

`iquERNATiGNAL SEARCH REPGRT
`inim‘matian 051 patent famiiy members
`
`..........................
`.
`international! applicafiion Nu
`
`2617112009/000644
`
`Paiefit [imminent
`Ciied in search repon‘
`
`Pubiicafi-Qn
`dale
`
`1
`:
`
`Patent iamiiy
`memherfig
`
`Publicafian
`date
`
`0E 3340974
`
`11
`
`23—051985
`
`08 2188238
`
`A
`
`30~09w1987
`
`3005148 A1
`
`20-~08~1987
`
`US 2006293719
`03 2008187599
`
`A1 28 122006 US
`A1 2808;2005 NGNE
`
`80 9312835
`
`A
`
`08~07~1993
`
`AU
`
`WU 0083113
`
`A
`
`14w09-2000
`
`.
`
`DE 3825168
`
`A1 2501~1990
`
`08 304887
`WO 2009047628
`
`A
`
`1303*1930
`1604~2009
`
`JP
`
`03
`
`Fo.'n FGT/{SA/210 (8.1m: fam1yannex) (AM 2N5)
`
`2008004679 A1
`
`03~01~2008
`
`3183493 A
`2058179 A1
`2277270
`8620463
`
`298536
`"
`779100
`2364008 A1
`60021063 01
`60021063 T2
`1158919 A1
`2240078 13
`4102031 82
`2002537939 T
`5A1J¢55 B1
`
`2807:1993
`21m06 1993
`26~10~1994
`15m04~1997
`
`18~07m2008
`06~01~2005
`1415912935
`04m08u2005
`11"08~2006
`08m12~2001
`16*10w2008
`18w06—2008
`12n1lw2002
`02~07m2002
`
`1918386 A
`
`18:071933
`
`NONE
`
`

`

`(12) INTERNATIQNAL APPLICATIQN FUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
`
`(19) W'eriti Inteliectuai Property Organizatinn .
`International Bureau
`
`(43) International Puliticafien Bate
`
`2i January 291% (21.91.2(5153) (10) international Publication Number
`
`Wt} Zilltl/tlthiIst A2
`
`Intet‘ttafitm :11 Patent Classifiealetm:
`.4 612V 7409006131)
`
`‘ AMN 2/90 (2006.00
`A MN 2/32 (2006.0l )
`
`Intet‘ttafitm al Applicatiun Number:
`
`PCL’ILEOO9/000644
`
`(22}
`
`Interna‘cianal Filing Date:
`
`29 June 2009 (29.06.2009)
`
`(25}
`
`’26“)
`
`(30)
`
`(71)
`
`(73)
`(75)
`
`Filing Language:
`
`Publicatimt Language:
`
`Priority Data:
`61/076,652
`51/1l2,783
`
`2,0 June 2008 (29.06.2008)
`lt') November EGGS (10.11.2068)
`
`English
`
`En glish
`
`US
`US
`
`(84)
`
`Applicant (for a]! designated States except US): VENUS
`TECHNOLQGIES LTD [TL/IL];
`38 Ha'Bat‘Zel St,
`6C 710 Tel Aviv (IL).
`
`lnveiitars; and
`Inveiitars/Appltcants g’or US only): RON EDOUTE,
`()de [lL/IL]; 14A Josef Milo St, 69643 Tel Ayiv (IL),
`RUN EBOUTE, Grit {BL/IL]; 14A Josef Milo St, 69643
`Tel Aviy (EL). KREMIN, Rahal; [IL/EL]; 7 Remez St,
`5324: (j'ivatayim (1L), I’ULYAKOV, Vttdim [EL/1L]; 38
`Henrietta, Sold St, 49532 Petaeh Tikva (EL),
`
`(74)
`
`Agent: DR. E ’AL BRESSLER L111;
`52522 Ramat Gan (IL).
`
`11 Tuval St.
`
`Designated} States (unless cit/zemise indicated, for may
`kind of national protection excitable): AE, AG, AL, AM.
`AG, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ,
`CA, CH. CL. CN, CO, CR. 2U, CZ. DE. DK, DM. DO.
`DZ, EC, EE EG, ES, FI, GB, GD, GE, GH, GM, GT,
`EIN, HR. HU, II), IL, IN, IS. JP, KE, KG, KM, KN, KP.
`KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD,
`ME, MG, MK, I» N, MW. MX. MY, MZ, NA, NG, NI,
`NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD.
`SF SG SK, SL SM, ST, SV, SY, TJ, TM, TN. TR, TT.
`TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
`
`Designated States (unless otherwise indicated, for every
`
`kind (JJfi‘egiana/ pram, for; available): ARIPO (BW, (3H.
`GM, KE, LS, MW, M23, NA, Si), SL, SZ, TZ, UG, 21M,
`ZW), Eurasian (AM, AZ, BY, KG, KZ, MD. RU, TJ,
`TM), European (AT, BE, BG, CH, CY, CZ, DE, UK, Eli.
`ES. FI, IR GB, GR, HR, HU, EE, ES, IT, LT, LU, LV.
`MC, MK, MT, NL, NO, PL, PT, RO, S}, SI, SK, TR),
`OAPI (BF, BL CF. CG, CE, CM, GA. GN, GQ, GW. ML,
`MR, NL, SN, TI), TG).
`
`”gelamfilms “Elder Rule 4‘17:
`(15: m applicant’s emiflemem m applyflor and he grained
`a patent (Rule 4.1' 761))
`
`[Continued 0:7 nextpage]
`
`(54) Title: AN ESTHHFlC APPARATUS USEFUL FOR {NCREASING SKIN REJUVENATION AND METHODS THEREOF
`
`(57) Abstract: The present invention provides a sys—
`tent for increasnig skin rejuvenation of a region of a
`patients skin comprising a pulsed electromagnetic
`field (PEME) frequency generator for constantly pm-
`Viding electromagnetic pulses to said region of a pa—
`tients skin and a deep tissue diathermy device for
`constantly applying heat to said region of a patient's
`skin up to temperature T. The system is adapted fer
`sirnulta tentisly applying heat and PEMF to theregion
`of a patients skin; wherein application of the system
`increases skin rejuvenation such that meant rejuve—
`nation increase (SR1) is greater than the sum of the
`SR1 pr‘ttvided by electromagnetic pulses increase and
`
`the SR1 provided by the deep tissue diathermy deyiee
`increase.
`
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`
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`frequency generator
`5\\____________________________________
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`

`

`W8 2019/0976E4 A2; lEEEIEEIIIEIEIIIEEEHEIIEIIiElEIIIEEIEElilllIEIEE|§[E§[EIIEEIEEI[E[EEIEEEEIEIEEEEHEEEIEIEEEE
`
`Publish-ed;
`
`-----
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`wirizauz internmimal search repafi and m be republished
`upon receipz offlmr minor; (Ride 482(ng
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`

`

`W'O 2618/0976”
`
`PCT/1L2009/Gfli'3644
`
`AN ESTHETEC APPARATUS USEFUL FUR INCREASING SKIN REJLWENATEON
`
`AND METHODS THEREQF
`
`FEELD 0}? THE ENVEN’I‘IQN
`
`This invention generally relates tc an esthetic device used to improve skin viability and skin
`
`rejuvenation, and a method at using the device“ ‘
`
`BACKGRGUND 0F THE IRWENTIGN '
`
`imprcving the appearance cf the skin has been the gcal, of many esthetic prcducts and
`
`precedures fer many years, since a tight skin, withcu’t wrinkles ct: cellulite, has a younger and
`
`more appeaiing appearance, Apart item age related changes, the skin alsc suffers from
`
`expcsure ’tc chemical and physical
`
`injuries, such as tobacco, ccsrnetics9 esthetics and
`
`radiation from the sun and other sources. These factors ccnttibnte to the decrease in collagen
`
`production, to reduced elasticity, and the appearance cf wrinkles.
`
`A few main approaches to tightening of the skin are common practice today. The surgical
`
`apprcach cairies disadvantages related in the anesthesia the stagicai ccmpiicaticns, and the
`
`healing precessawbicii may cause scars, The chemicai peel approach usually involves injury
`
`tc tlte catermnst layer of the skin m the epidermis m which may cause disccicraticn. Since
`
`ccllagen fibers are fauna in the dermis 7n the subcutaneens layer at the sitting and since heat
`
`was strewn tc ccnttact these fibers and generate their production {Zelickscn Bi), Kist if);
`
`Bernstein E, Brown DB, Ksenzenkc 8, Burns L Kihner SS, Mehregan 33, Pope K Histological
`
`and ultrastrncturai evaluation. cf the effects of a radici’reque,ncy~besed ncnablative dcmnal
`
`remedeiing device: a pilct shitty” Arch. Demiatcli 2304 Febfiéltlfljz'ZM—Q], nrethcds of
`
`differentially heating the demtis (deep tissue diathenny} have recentiy arisen
`
`A unique method of treating the dermis is called Pulsed Electrcmagnetic Fields (FEM?)
`
`therapy. This methcd asuaiiy emplcys electromagnetic radiaticn of different frequencies ~
`
`ranging item static magnetic tieldsa thtcagh extremely low frequencies (ELF) tc higher
`
`radicfrequencies (RF) -- administered in puises.
`
`FEM}? wants in few ways. Due to the radiation absorbed in the tissue, it can be heated tc
`
`various temperatures, depending on the newer applied, the frequency transmitted, and mate
`
`importantly the tissue characteristics Eventually, the tissue can be warmed to denaturaticn
`
`temperatures, which cause ccagutaticn necrcsis and tissue damage. It can aisc be heated to
`
`

`

`W'O Zillll/{lil’iélél
`
`PCT/letlllfi/llillltlaléi
`
`lower temperatures which proved to result in the alorewineritioned contraction of collagen
`
`fibers.
`
`Another monies operandi
`
`involves non thean effects. These rely on specific tissue
`
`components and their reaction to the applied isolation characteristics. These effects might be
`
`clue to large charged molecules and their reaction to various frequencies and frequency
`
`harmonies charged small
`
`ions in the cell membranes effecting the cells function and
`
`reactions to hormones and chemical signals, charged smell ions in the extracellular space and
`
`other poorly turtlerstoocl mechanisms.
`
`Furtliennoreg applying the radiation in. pulses was also found to have non thermal effects. Yet
`
`more, only a specific combination ofliceCeleney> duty cycle and transmitted power achieve e
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`specific tissue response. Recent scientific research has confronted these challenges and found
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`the PEMF characteristics needed for the desired biophysical response.
`
`it is now commonly accepted that weak electromagnetic iielcis (EMF) sciministereci in pulses
`
`are capable of initiating various healing processes in fractures, multiple sclerosis and
`
`Parkinson’s disease, and even delivering pain relief; however it seems that most of the
`
`allowed the use of pulsed reclioirequency electromagnetic field for treatment of pain and
`
`edema,
`
`in superficial soft
`
`tissues tWo decades ago.
`
`[Roscl’e Pl, Markov, M.S., eds.
`
`Bioelectromegnetic Medicine, Marcel Dekkerg NY, 25% 264—]:
`
`The use of PEMF can also be recruited for cosmetic purposes as described. above” Several
`
`studies have addressed the etlect of PER/ll? on clerrnel components. For example, in rive trials
`
`showed that pulsed electromagnetic field of certain field intensities and frequencies increased
`
`epidermal collagen synthesis [Arlinedian S, Zerc‘ni SR, Bolouri B. Effects of extremelych
`
`v frequency pulsed; electromagnetic fields on collagen synthesis in rat skin. Bioteclinol Appl
`
`Biochem. 2006 Feb;43(l3t 2):7l~5}. This new formed collagen increases sliin elasticity and.
`
`rejuvenates its appearance.
`
`in azure trials showed that PER/ll?” increased the clegree of endothelial cell tubulizetioo and
`prolileratiom and augmented engiogenesis primarily by stimulating enclotheliel release of
`
`PEP—2, inducing peraorine and eutocrine changes in the smrounding tissue l’l‘epper QM et cl.
`
`Electromagnetic fields increase in vitro and in Vivo engiogenesis through endotlielial release
`
`of FGF—2, FASEB 3. 2.004 Augglgfl l):l23lu3. Epuls 20% Jun l8}. Angiogenesis,
`
`the
`
`sprouting of new blood; vessels, increases blood flow to the tissues which. in turn increases
`
`oxygen and nutritional substances delivery to the tissue. This effect is most beneficial for an
`
`{X}
`
`

`

`‘WO 2i” 6/0876”
`
`FCTI'IIJZOGQ/fliiQe‘i-i
`
`injured tissue? promoting rapid and improved heating. The. growth factor released tanner
`
`enhances the heating process? both in qnaiity and time of improvement,
`
`The scientific evidence of the effect of FEM? on tissues was utilized in various applications,
`
`For example, USZO€350182462A1
`
`discloses. healthy deep tissue heating using FEM? for the
`
`purpose of causing contraction and tightening ot'the skirt
`
`FEMF has also been used to improve skin wound heaiing. For example, “7008964272
`
`discloses a method of treating a severe diabetic nicer using PEME The patent also discloses
`
`the addition of intermittent compression therapy (iCT) and the use of tow intensity ultrasound
`
`{up to 50 W/thz), the latter aimed at inhibiting microbiai growth.
`
`Other methods of heating the dermis used non pulsating RF radiation applied by antenna or
`
`electrodes. For example, W093005380 discloses a method of tightenhig skin using an. R}?
`
`electromagnetic energy delivery device.
`
`‘
`
`improving the results of skin tightening based on dermis diathermy is siiii a iong felt need,
`
`both for est‘netic and therapeutic purposes.
`
`SUMMARY 0F THE {NVENTEON
`
`‘t is one object ot’ti‘le present invention to provide a system (i0) adapted to increase skin
`
`reinvenation of a region of a patients skin, said system comprising
`
`a.
`
`b.
`
`a poised eiectromagnetic field (PEMF) trequency generator (2) tier constantly
`
`providing electromagnetic pulses. to said region of a patients skin; and,
`
`a deep tissue diathermy device (4) for constantly applying heat to said region
`
`of a patients skin up to temperature T;
`
`said system {i0} is adapted for simuiteneonsly appiying teat and PEMF to said region of a
`
`patients skin; wherein appiication of said system increases said skin rej ovenation such that”
`
`said skin rejuvenation increase (SR1) is greater than the sun: of said Silii provided by
`
`electromagnetic noises increase and said SR1 provided by said deep tissue diathermy device
`
`increase.
`
`pt is another object Ofthti present invention to provide the system as defined above: wherein
`
`said eieetromagnetic pulse is a triangular shaped at frequency of 25 Hz and intensity of 20
`
`Gauss.
`
`it is another object of the present invention to provide the system as defined abovea wherein
`
`said electromagnetic pnise is square shaped at a ireqnency of 16 Hz, duration of about 5
`
`miiiiseconds and intensity of 12 Gauss.
`
`Lax!
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`

`

`W’O Zfiifi/Gfl’féiéi
`
`.
`
`PC'i‘liLZfifiii/iifliiddd
`
`it is another object of the present invention to provide the system as defined aboveB wherein
`
`said deep tissue diathermy device (4) is selected from any device emitting RF radiation or
`
`any means adapted for producing electrical current absorbed by subcutaneous tissue.
`
`it is another object oi‘tiie present invention to provide the system as defined above, wherein
`
`said deep tissue diathermy device (4) sdditionaiiy comprises:
`
`a.
`
`be
`
`‘
`
`t
`
`st ieest one electrical output device adapted to generate RF electromagnetic
`
`energy;
`
`at ieest two electrodes eieeuieaiiy eoupied to said electrical output device and
`
`pieced on said skin region; wherein aii said eieetrodes are adapted,
`
`to
`
`simultaneously appiy said RF energy to said skin region“
`
`it is another obj ect ofthe present invention to provide the system as defined above, wherein
`
`said deep tissue diathermy device (4) edditioneiiy comprises:
`
`a
`
`h.
`
`at least one eieetrieai output device adapted to generate electrical current;
`
`at ieest two eieetrodes eiee’rriesiiy coupled to said eieetrieai output device and
`
`pissed on said skin region, wherein aii said electrodes are adapted to
`
`siinuitaneousiy appiy said electrical current to said skin region.
`
`it is another objeet of the present invention to provide the system as defined above, wherein
`
`said systemreduees side effects end/or harmful eiiieets of said electromagnetic pulses and/or
`
`said deep tissue diathermy such that said reduction of said side effects and/or said harmfui
`
`effects is greater than the sum of said reduction of said eiee’rromagnetie puises end/or said
`
`reduction of said deep tissue diathermy.
`
`it is another obj eot ofthe present invention to provide the system as defined above“. wherein
`
`said system additionally comprising a eontrei
`
`system (6) adapted to regulate said
`
`eieetromsgnetie pulses end/or said eieetromagnetio ou‘ises.
`
`it is another object of the present invention to provide the system as defined above, wherein.
`
`said puised eiectromagnetie frequency generator is adapted to previde a dynamic magnetic
`
`field such that said eieetromagnetie pulses vary with time.
`
`it is another object or" the present invention to provide the system as defined above, wherein
`
`the shape of said eieetroniagnetie poise is seieeted in a nondimiting manner from a group
`
`eonsisthig or” square wave, a sine were, a trienguier were, sawtooth wave, ramp were;
`
`spiked wave or any other mathematics} combination
`
`it. is another object oftiie present invention to provide the system as defined above, wherein
`
`the magnetic fieid intensity B of each praise applied by said pulsed electromagnetic frequency
`
`generator (2) ranges between about 0 and about 3 Tesla
`
`

`

`W'O ENG/007614
`
`PCT/lethfi/thtitidét
`
`it is another o‘oj eat of the present invention to provide the system as defined above, wherein
`
`the situation of each pulse appiied by said pulsed el otrornagnerie frequency generator (2)
`
`ranges between about 3 and about ithO milliseconds.
`
`it is another obj eat of the present invention to provide the system as defined above, Wherein
`
`the frequency i7 applied by the pulses of said pulsed eieetromagnetio frequency generator (2}
`
`ranges between. about 1 Hz and about iMiiz.’
`
`it is another object of the present invention to provide the system as defined above, wherein
`
`the energy E applied by the pulses of said pulsed electromagnetic frequency generator (:2)
`
`ranges between about 1 and about 150 watts per pulse,
`
`it is another object of the present invention to provide the system as defined. above, wherein
`
`said deep tissue diathermy device {4) is selected in. a nonulirniting manner from a group
`
`consisting of an ultrasonic diathermy, an optieai device, electromagnetic induction, sound
`
`Waves emitting instrument, direct heat applying instrtnnent, or from any other means of
`
`heating subcutaneous tissue to temperature T.
`
`it is another object of the present invention to provide the system as defined above, wherein
`
`said optieai device is adapted to emit light in wavelengths absorbed by subcutaneous tissue
`
`such that said suheutaneous tissue is heated.
`
`it is another object of the present invention to provide the system as defined above, wherein
`
`said sound Waves emitting instrument is adapted to emit sound waves absorbed by the
`
`subcutaneous tissue such. that said subcutaneous tissue is heated.
`
`it is another object of the present invention to provide the syste r as defined above, wherein
`
`said temperature T is higher than stout 30 and lower than about 80 degrees.
`
`it is another object of the present invention to provide tire system as defined above, wherein
`
`said power supply and eontroi system (6) monitors physical tissue parameters and changes
`
`applied heat and eieetroniagnetie puises accordingly.
`
`it is another object of the present invention. to provide the system as defined. above, wherein
`
`said power supply and eontroi system (6) additionaliy comprising: ’
`
`a,
`
`processing means, adapted to store in a ooninurnioabie database predetermined 1
`
`parameters defining (i) safe treatment parameters and (ii) unsafe treatment
`
`. parameters; said parameters are selected from a group consisting of tirne t of
`
`said treatment, temperature T of said tissue, ratio t’Tl‘, Frequency F, power P,
`
`V energy E" applied by the pulses of said pulsed electromagnetic frequency
`
`generator, depth D of said treated tissue, magnetic: field inteisity B, tissue
`
`

`

`W'O ENG/007614
`
`PCT/letiOfi/Giititiatéi
`
`impedance, Specific absorption rate (EAR), treatment depthg soperfieiai muscle
`
`contractions or a combination thereof;
`
`b.
`
`sensing means; adapted to sense electromagnetic radiation and heat radiation
`
`parameters seieeted from a group consisting of time t of time t of said
`
`treatment temperature T of said tissue~ ratio t/T, Frequency i7> power P,
`
`Intensity i of said nitrasonnd irradiation energy E applied by the pulses of said
`
`poised electromagnetic frequency generator, depth if) of said treated tissue,
`
`magnetic field intensity B: tissue impedance, specific absorption rate {EAR};
`
`treatment depth? superiieiai muscle contractions or a combination thereof;
`
`or
`
`regulating means, adapted to aiiow said electromagnetic radiation and heat
`
`ratiiation if said parameters are within said safe treatment parameters and to
`
`stop the electromagnetic radiation ii’t‘oe radiation parameters are in said unsafe
`
`treatment parameters.
`
`it is another object of the present invention to provide the system as defined above, wherein
`
`said power supply and. oontroi system (6) inoiodes a mechanism for skin cooiing,
`
`it is another object of the present invention to provide the system as defined above, wherein
`
`said system (it?) is encased in at ieast one platform.
`
`it is another obj act of the present invention to provide the system as defined above, wherein
`
`said poised electromagnetic frequency generator {2} and said deep tissue diathermy device (4)
`
`have more than one applicator to treat more than one body part simuitaneonsiy.
`
`it is another obj eot of the present invention to provide the system as defined abovea wherein
`
`said poised eieotromagnetic frequency generator {2) has eieetrostatio shieiding.
`
`it is another obj ee‘t ofthe present invention to provide the system as defined above: especiaiiy
`adapted to increase skin rejuvenation in. the immediate (short) range.
`I
`
`it is another object of the present invention to provide the system as defined above, especiaiiy
`
`adapted to increase skin rejuvenation in the intermediate range,
`
`it is another object of the present invention to provide the system as defined above, especiaiiy
`
`adapted to increase skin rej nvenation in the longrange;
`
`it is another object of the present invention to provide the system as defined above; wherein
`
`said system is especiaiiy adapted to operate according to [EC seieeteci from a group
`
`consisting of EC 60601—235, EEC 6069iu2~33,
`
`iEC 606014149, EEC 60601~2~9,
`
`i‘EC
`
`60601—25, EEC 60601~2~3, iii-EC 60607343: iEC 60601443, iEC 6060144, IEC 6060144,
`
`iEiC 606014—23 EEC 6.306014% or any combination thereof:
`
`

`

`W'O ENG/007614
`
`PCT/lefiflfi/GMBGM
`
`it is another object of the present invention to provide e method {4-00) of increasing skin
`
`rejuvenation of a region of a patients skin. The method comprises steps seieeied inter aiie
`
`from:
`
`in
`
`i3.
`
`e.
`
`obtaining {it} puiseci electromagnetic frequency generator; and, (ii) a deep
`
`tissue diaiherniy deviee;
`
`appiying heat io a subcutaneous "tissue within said region up to temperature T;
`
`and,
`
`applying puises of electromagnetic fieiri to said region;
`
`wherein said increasing of said skin rejuvenation is greater than the sum of said applying heat
`
`‘
`
`to a subcutaneous tissue Wiiiiiu said region increase and said eppiying penises eieetromagneiie
`
`therapy to said region inerease.
`
`it is another object of the present invention to provide a method (410) of increasing skin
`
`' iejuveneiion of a region of e paiient’s skin. The method comprises steps seieeted inter aiia
`
`from:
`
`at
`
`b.
`
`e.
`
`obtaining (i) pulsed eieetromegnetie frequency generator; and, (ii) a deep
`
`tissue diathermy device;
`
`applying pulses oi‘eieeuornngneiie iieid to said region; and,
`
`applying heat to a subcutaneous tissue within said region up