Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.U800
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`Amendments to the Specification:
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`Please amend the Specification as follows:
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`Please amend [0016] as follows:
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`[0016]
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`Figures 4a and 4b illustrate a combined treatment with optical waves
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`generating device powered by magnetic field generated by magnetic field generating
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`device.
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`LIST OF REFERENCE NUMBERS
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`1
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`2
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`3
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`4
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`5
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`6
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`7
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`8
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`9
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`10
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`11
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`12
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`13
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`14
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`15
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`16
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`optical treatment device
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`energy source
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`hardware panel for optical treatment
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`optical waves generating device
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`optical treatment applicator
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`magnetic treatment device
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`energy source
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`hardware panel for magnetic treatment
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`magnetic field generating device
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`magnetic treatment applicator
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`combined treatment device
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`energy source
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`hardware panel for optical treatment
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`optical waves generating device
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`optical treatment applicator
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`hardware panel for magnetic treatment
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`66964-8034.US00/134971137.1
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`

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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
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`Attorney Dkt. N0. 066964-8034.USOO
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`17
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`18
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`magnetic field generating device
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`magnetic treatment applicator
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`19
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`combined treatment device
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`2O
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`21
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`22
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`23
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`24
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`25
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`energy source
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`hardware panel
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`optical waves generating device
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`optical treatment applicator
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`magnetic field generating device
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`magnetic treatment applicator
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`26
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`combined treatment device
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`27
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`28
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`29
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`3O
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`31
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`32
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`energy source
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`hardware panel for optical treatment
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`optical waves generating device
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`applicator
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`hardware panel for magnetic treatment
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`magnetic field generating device
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`33
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`combined treatment device
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`34
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`35
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`36
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`37
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`38
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`39
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`energy source
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`hardware panel
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`optical waves generating device
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`magnetic field generating device
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`applicator
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`magnetic field generating device
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`66964-8034.US00/134971137.1
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.USOO
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`40
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`conductor loop
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`41
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`42
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`light source
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`coil
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`43
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`circuit wires
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`44
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`45
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`46
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`47
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`48
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`49
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`50
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`51
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`fastening point
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`blower
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`applicator
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`arrows
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`casing
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`outlet
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`connecting tube
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`conduit
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`52
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`switch
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`53
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`coil
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`54
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`55
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`56
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`57
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`58
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`59
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`energy storage device
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`ener
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`source
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`protecting circuitry
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`coil
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`energy storage device
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`switch
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`60
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`ener
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`source
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`66964-8034.US00/134971137.1
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`

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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.U800
`
`At page 5, after paragraph 0016 (as amended above) and before “LIST OF
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`REFERENCE NUMBERS”, please add new paragraphs 0016.1- 0016.5 as follows:
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`[0016.1]
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`Figure 5 is a cross section of view of a coil winding.
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`[0016.2]
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`Figure 6 is an illustrative embodiment of cross-section of the magnetic
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`applicator.
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`[0016.3]
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`Figure 7 is an illustrative embodiment of a casing of
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`the magnetic
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`applicator.
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`[0016.4]
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`Figure 8A and 8B illustrate circuit for providing high power impulses to a
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`stimulating coil.
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`[0016.5]
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`Figure 9 is a graph showing voltage drop in the energy storage device.
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`Please add new paragraphs 0037.1 to 0037. 21 as follows:
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`[0037.1]
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`The methods recites above may be enabled by a device described in
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`Figures 5 to 9.
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`[0037.2]
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`Fig. 5 illustrates a cross section of winding of a coil for a magnetic
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`stimulation device. The coil may be constructed from litz-wire, wherein each wire is
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`insulated separately. Each individual conductor is coated with non-conductive material
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`so the coil constitutes multiple insulated wires. Unlike existing magnetic coil conductors,
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`the present coil
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`is not made of bare wire e.g.
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`litz-wire without insulation, or conductive
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`tapes, conductive strips, or copper pipe with hollow inductors. The insulation of wires
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`separately is a substantial improvement, since this leads to a significant reduction of the
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`induced eddy currents. Power loss due to eddy currents, per single wire, is described by
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`Equation 1 below. The small diameter wires of the present coil significantly reduce self-
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`66964-8034.US00/134971137.1
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.USOO
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`heating of the coil and therefore increases efficiency of the present magnetic stimulation
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`device.
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`72-2 'B2 'd2 “f2
`P =P—,
`6"“ka
`EDDY
`
`E . 1
`q
`
`[0037.3]
`
`where:
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`PEDDy is power loss per unit mass (W-kg'1); Bp is the peak of
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`magnetic field (T); f is frequency (Hz); d is the thickness of the sheet or diameter of the
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`wire (m); k is constant equal to 1 for a thin sheet and 2 for a thin wire; p is the resistivity
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`of material (Q-m); D is the density of material (kg-m3).
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`[0037.4]
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`The individual
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`insulation of each wire reduces eddy currents. The
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`individually insulated wires may be wound either one by one or
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`in a bundle of
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`individually insulated wires so as to form a coil, which will serve as a magnetic field
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`generator. The coil provides an improvement in the efficiency of energy transfer in the
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`LC resonant circuit and also reduces or eliminates unwanted thermal effects.
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`[0037.5]
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`The coil may have a planar coil shape where the individually insulated
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`wires may have cross-section wires with conductor diameter less than 3 mm even more
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`preferably less than 0.5 mm and most preferably less than 0.05 mm. The wires are
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`preferably made of materials with higher density and higher resistivity e.g. gold,
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`platinum or copper. The diameters of the single wires should be minimal. On the other
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`hand the total diameter should be maximal because of inverse proportion between the
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`cross-section of all wires forming the coil and the electrical resistance. Therefore the
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`ohmic part of the heat is then lower. Eq. 2 describes power loss of the coil:
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`66964-8034.US00/134971137.1
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.USOO
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`[0037.6]
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`Where:
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`PR is the power loss heat dissipation (W);,o is the resistance
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`(Q-m); /is the length of wire (m); S is the surface area (m2);
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`/ is the current (A) and m is
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`1 kg of wire material.
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`[0037.7]
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`Total power loss is (Eq.3):
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`[0037.8]
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`Where: PTOT is
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`the total power
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`losses (W-kg'1); PEDDy is
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`the power
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`PTOTZPEDDY+PR’
`
`Eq'3
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`dissipation of eddy currents (W-kg'1); PR is the power loss heat dissipation (W-kg'1).
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`[0037.9]
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`Dynamic forces produced by current pulses passing through the wires of
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`the coil cause vibrations and unwanted noise. The individual insulated wires of the coil
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`may be impregnated under pressure so as to eliminate air bubbles between the
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`individual insulated wires. The space between wires can be filled with suitable material
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`which causes unification, preservation and electric insulation of the system. Suitable
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`rigid impregnation materials like resin, and elastic materials like PTE can be also used.
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`With the coil provided as a solid mass,
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`the vibrations and resonance caused by
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`movements of
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`the individual
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`insulated wires are suppressed. Therefore noise is
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`reduced.
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`[0037.10]
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`The coil may be attached to the case of the applicator, such as a hand
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`held applicator of the magnetic stimulation device; build-in applicator in e.g. chair, bed;
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`or stand-alone applicator e.g. on mechanical fixture. The attachment may be provided
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`by an elastic material e.g., silicone, gum; or other flexible manner. Connection with the
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`coil of the applicator’s case can be ensured by several points. The several fastening
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`points ensure the connection of the coil to the casing by flexible material so that the
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`main part of the coil and the main part of the casing of applicator are spaced apart. The
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.U800
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`spacing should be at least 0.1 mm so that air can easily flow. The gap between the coil
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`and the casing can be used either for spontaneous or controlled cooling. The coil may
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`optionally be connected to the case of the applicator by only one fastening point. The
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`fastening points eliminate vibrations of wires which could be transferred to housing of
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`the applicator and therefore reduce noise of the magnetic stimulation device.
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`[0037.11]
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`Fig. 6 is a cross-section of the magnetic applicator which allows better
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`flow on the lower and upper sides of the coil and thus more efficient heat dissipation.
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`The magnetic stimulation device includes a coil 42,
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`the circuit wires 43 and the
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`fastening points 44 for connection of the coil to the casing of the applicator (not shown).
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`The fastening points 44 are preferably made of flexible material however the rigid
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`material may be used as well. The fastening points 44 may be located on the outer
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`circumferential side of the coil. However, alternatively it
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`is possible to put
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`these
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`fastening points to a lower or upper side of the coil.
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`[0037.12]
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`The fastening points 44 connect the coil to the case of the applicator in at
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`least one point. The fastening points 44 maintain the coil and the main part of the case
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`of the applicator spaced apart so that fluid (which may be air or any liquid) can flow
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`between them. At least one blower 45 can be placed around the circumference of the
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`coil, or perpendicular to the coil. The blower can be any known kind of device for
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`directing the fluid e.g. outer air directed into the case of
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`the applicator. This
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`arrangement of the blower allows air to bypass the coil from upper and lower (patient’s)
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`sides.
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`In still another embodiment the outer air can be cooled before directing into the
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`case. The blower can have an inlet placed around the circumference of the coil for
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`injecting air, to remove heat from the coil. A connecting tube (not shown) can ensure
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`66964-8034.US00/134971137.1
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.U800
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`connection of the applicator 46 with the energy source and/or control unit of magnetic
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`stimulation device. The connecting tube may also contain a conduit of the fluid.
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`[0037.13]
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`The arrows 47 indicate the air flow through the applicator 46. This
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`arrangement of the blower allows the air to bypass the coil from upper and lower
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`(patient’s) side. Outlet may be preferably placed on upper side of the casing. By placing
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`the blower around the circumference of the coil instead of on the top/below the coil, the
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`blower 45 does not interfere with the magnetic flux peak and therefore its lifespan and
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`reliability is increased.
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`[0037.14]
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`Fig. 7 is an illustrative embodiment of a casing of the magnetic applicator.
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`The overview drawing contains casing itself 48, which might contain an outlet 49
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`preferably placed on upper side of the casing 48. A connecting tube 50 may not only
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`ensure connection of the applicator with the energy source and/or control unit of
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`magnetic stimulation device, but also connection to a source of the fluid; however the
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`conduit of the fluid 51 may also be connected separately.
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`[0037.15]
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`Fig. 8A and Fig. 8B illustrate circuits for providing high power pulses to the
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`stimulating coil. Fig. 8A shows a circuit for providing high power magnetic pulses. Fig.
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`8B shows a circuit for providing high power pulses.
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`[0037.16]
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`The state of art magnetic stimulation device achieves magnetic flux
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`density of a few tenths to several ones of Tesla. To achieve this level of magnetic flux
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`density, the energy source used generates sufficient voltage. This voltage can reach
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`thousands of volts.
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`In Fig. 8A the circuits for providing high power pulses to the
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`stimulating coil contain a series connection to the switch 52 and the coil 53. The switch
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`52 and the coil 53 together are connected in parallel with an energy storage device 54.
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`66964-8034.US00/134971137.1
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.U800
`
`The energy storage device 54 is charged by the energy source 55 and the energy
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`storage device 54 then discharges through the switching device 52 to the coil 53.
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`[0037.17]
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`During second half-period of LC resonance,
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`the polarity on the energy
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`storage device 54 is reversed in comparison with the energy source 55.
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`In this second
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`half-period, there is a conflict between energy source 55, where voltage on positive and
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`negative terminals is typically thousands of Volts. The energy storage device 54 is also
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`charged to the positive and negative voltage generally to thousands of Volts. As a
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`result, there is in the circuit, consequently, twice the voltage of the energy source 55.
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`Hence the energy source 55 and all parts connected in the circuit are designed for a
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`high voltage load. Therefore, the protective resistors and/or protection circuitry 56 must
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`be placed between energy source 55 and energy storage device 54. Disadvantage of
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`state of art solution is
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`large amount of energy transformed to undesired heat
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`in
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`protective resistors and/or protection circuitry 56.
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`[0037.18]
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`Fig. 8B shows a circuit for providing high power pulses for improved
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`function of the magnet stimulation device. The coil 57 and an energy storage device 58
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`are connected in series and disposed in parallel to the switch 59. The energy storage
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`device 58 is charged through the coil 57. To provide an energy pulse, controlled
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`shorting of energy source 60 takes place through the switch 46.
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`In this way the high
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`voltage load at the terminals of the energy source 60 during the second half-period of
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`LC resonance associated with known devices is avoided. The voltage on the terminals
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`of energy source 60 during second half-period of LC resonance is a voltage equal to the
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`voltage drop on the switch 59.
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`66964-8034.US00/134971137.1
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.U800
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`[0037.19]
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`The switch 59 can be any kind of switch such as diode, MOSFET, JFET,
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`IGBT, BJT, thyristor or their combination. Depending on the type of component the load
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`of energy source 60 is reduced to a few Volts, e.g., 1-10 volts. Consequently, it is not
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`necessary to protect the energy source 60 from a high voltage load, e.g., thousands of
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`Volts. The use of protective resistors and/or protection circuits is reduced or eliminated.
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`The present designs simplify the circuits used, increase efficiency of energy usage and
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`provide higher safety.
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`[0037.20]
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`Fig. 9 shows an exponential voltage drop in the energy storage device.
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`Energy savings during time-varying magnetic therapy may be characterized by reduced
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`voltage drop in the energy storage device between the first, second and subsequent
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`maximums of
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`the resonant oscillation. The magnitude of
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`the individual voltage
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`oscillations is exponentially dampened up to establishing the energy balance. This
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`allows increasing the maximum possible frequency/repetition rate of magnetic pulses,
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`since the frequency/repetition rate is dependent on the speed with which it is possible to
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`recharge the energy storage device. Since the energy storage device is recharged by
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`the amount of energy loss during the previous pulse,
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`it
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`is possible to increase the
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`frequency/repetition rate of the device up to hundreds of magnetic pulses per second
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`without the need to increase the input power. The voltage drop between any of the
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`successive amplitudes is not higher than 21 %, even more preferably not higher than
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`14 % and most preferably not higher than 7 %.
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`[0037.21]
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`The device can be used for treatment/successive treatments in continual,
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`interrupted or various duty cycle regime. The duty cycle may be higher than 10 %,
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`which means interrupted regime with the ratio up to 1 active to 9 passive time units. The
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`66964-8034.US00/134971137.1
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`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.USOO
`
`ratio may possibly change during the therapy. The device enables operation defined by
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`the peak to peak magnetic flux density on the coil surface at least 3 T, more preferably
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`at least 2.25 T, most preferably at least 1.5 T at repetition rates above 50 Hz, more
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`preferably at repetition rates above 60 Hz, even more preferably at repetition rates
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`above 70, most preferably at repetition rates above 80 Hz with treatment/successive
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`treatments lasting several seconds or longer, for example, for at least 5, 10, 30, 60, 120
`
`or 240 seconds, or longer. The total power consumption is below 1.3 kW and the width
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`of pulses is in the range of hundreds of us.
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`66964-8034.USOO/134971137.1
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`17
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`

`

`Application No. 15/396,073
`Reply to Office Action dated 03/24/2017
`
`Attorney Dkt. No. 066964-8034.U800
`
`Please amend paragraph 0038 as follows:
`
`[0038]
`
`A magnetic treatment device may include at
`
`least one energy source
`
`and/or connection to the energy source, at least one switching device, at least one
`
`energy storage device, e.g. a capacitor, and at least one magnetic field generating
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`device, e.g. a coil. The generated magnetic field may be time varying, preferably pulsed.
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`The magnetic treatment is provided by a peak to peak magnetic flux density on the coil
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`surface of at least 0.1, 0.5, 0.8, 1, 1.5, 2, 2.4 or up to 7 Tesla at repetition rate of at least
`
`0.1, 0.5, 1, 10, 30, 50, 55, 60, 80 or up to 700 Hertz with treatment/successive
`
`treatments lasting several seconds or longer, e.g. at least 5, 10, 30, 60, 120 or 240
`
`seconds, or longer. The pulse width is in the range of tens to hundreds of us, preferably
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`in the range of 100 to 600 us, most preferably in the range of 250 to 350 us. Based on
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`achievement of repetition rates in order of few hundreds the device also enables
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`assemblin the ma netic ulses into the various sha es e.
`
`.
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`trian ular
`
`rectan ular
`
`exponential), with the shape widths from 6 ms to several seconds or longer. The
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`magnetic treatment may vary the amplitude,
`
`repetition rate and/or impulse duration
`
`during the treatment,
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`i.e.
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`the magnetic treatment may be modulated in amplitude
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`domain, repetition rate domain and/or in impulse duration domain. The shape of the
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`magnetic treatment may be adjusted following the patient’s needs.
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`Please delete paragraphs 0040 and 0041 entirely.
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