AVN—OOQDVCNb
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`embodiments, conjugation of the peptide to the oiigomer may be at the 5’ end of
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`the oiigomer,
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`in yet other embodiments, the peptide may be conjugated to the
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`oiigomer through any of the intersubunit iinkages.
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`in some embodiments, the peptide is conjugated to the oiigomer at
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`the 5’ end of the oiigomer.
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`in embodiments comprising phosphorus—containing
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`intersubunit iinkages, the peptide may be conjugated to the oiigomer via a covaient
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`bond to the phosphorous of the terminai iinkage group, Conjugation in this manner
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`may be with or without the tinker moiety described above.
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`in yet other embodiments,
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`the peptide may be conjugated to the
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`oiigomer at the 3’ end of the oiigomer.
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`in some further embodiments, the peptide
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`may be conjugated to the nitrogen atom of the 3’ terminai morpoiino group of the
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`oiigomer.
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`in this respect, the peptide may be conjugated to the oiigomer directiy or
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`via the tinker moiety described above.
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`in some embodiments, the oiigomer may be conjugated to a moiety
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`that enhances the soiubiiity ot the oiigomer
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`in aqueous medium.
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`in some
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`embodiments,
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`the moiety that enhances soiubiiity of the oiigomer in aqueous
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`medium is a poiyethyienegiycoi,
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`in yet further embodiments,
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`the moiety that
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`enhances soiubiiity of the oiigomer in aqueous medium is triethyiene giycoi. For
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`exampie,
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`in some embodiments the moiety that enhances soiubiiity in aqueous
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`medium may be conjugated to the oiigomer at
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`the 5’ end of the oiigomer.
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`Conjugation of the moiety that enhances soiubiiity of the oiigomer in aqueous
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`medium to the oiigomer may be either directiy or through the tinker moiety
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`described above.
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`Certain embodiments of the present
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`invention provide antisense
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`moiecuies seiected and or adapted to aid in the prophyiactic or therapeutic
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`treatment of a genetic disorder comprising at ieast an antisense moiecuie in a form
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`suitabie for deiiyery to a patient,
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`Certain embodiments of the invention provide methods for treating a
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`patient suffering from a genetic disease wherein there is a mutation in a gene
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`it)
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`15
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`20
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`25
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`10
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`