Substitute for form 1449/PTO
`
`Complete ifKnown
`
`E uivalent of Form PTO/SB/OBa 07-09)
`
`2293.1220001/PAC/E-H/lVl-S
`
`INFORMATION DISCLOSURE
`
`STATEMENT BY APPLICANT
`(Use as many sheets as necessary)
`
`Attorney Docket Number
`
`1643
`T0 Be Assigned
`
`U.S. PATENT DOCUMENTS
`
`Cltel
`
`DocumentN—mber
`Number—Kind Code 2 (If
`
`Relevant Passages or Relevant Figures Appear known)
`
`Publication Date
`lVJM—DD—YYYY
`
`Name of Patentee or
`Applicant of Cited Document
`
`Pages, Columns, Lines, Where
`
`Examiner
`initials*
`
`MN
`
`W w m
`
`-———
`-———
`-———
`-———
`-———
`-———
`-———
`-———
`-———
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`
`
`_FOREIGN PATENT DOCUMENTS
`
`_oreignPatent Document
`~
`~
`1
`L'
`Name of Patentee or
`Cite
`Publication
`Pages, Co umns,
`Ines,
`.
`.
`Date
`Where Relevant Passages
`t c d 3 —N mb
`.
`No1C0un ry
`0 e
`u
`er4
`MM-DD—YYYY
`Appl1cant OfCItEd Document
`or Relevant Figures Appear
`Kind Code5 (If known)
`ONCOMED
`WO 2008/042236 A2
`04-10-2008
`PHARMACEUTICALS, INC. et a]. _
`WO 2015/175599 A2
`11-19-2015
`PHARMACEUTICALS INC. _
`
`Examiner
`.
`.
`.
`*
`1n1t1als
`m0
`mm
`
`ONCOMED
`
`
`
`50334l9il.d0CX
`
`Examiner Signature— Date Considered —
`
`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance
`and not considered. Include copy of this form with next communication to applicant.
`1 Applicant’s unique citation designation number (optional).
`2 See
`Kinds Codes of USPTO Patent Documents at www.uspto.gov or MPEP 901.04.
`3 Enter Office that issued the document, by the two-letter code (WIPO
`Standard ST.3). 4 For Japanese patent documents, the indication of the year of the reign of the Emperor must precede the serial number of the patent
`document. 5 Kind of document by the appropriate symbols as indicated on the document under WIPO Standard ST.l6 if possible. 6 Applicant is to place a
`check mark here if English language Translation is attached.
`
`

`

`Substitute for form 1449/PTO
`
`Complete ifKnown
`
`E uivalent of Form PTO/SB/08b
`
`-09)
`
`INFORMATION DISCLOSURE
`
`STATEMENT BY APPLICANT
`(Use as many sheets as necessary)
`
`Attorney Docket Number
`
`1643
`T0 Be Assigned
`2293.1220001/PAC/E-H/lVI-S
`
`NON PATENT LITERATURE DOCUMENTS
`
`Examiner
`Initials"<
`
`Include name of the author (in CAPITAL LETTERS), title of the article (when
`appropriate), title of the item (book, magazine, journal, serial, symposium, catalog, etc.),
`date, page(s), volume-issue number(s), publisher, city and/or country where published
`
`BARROW, AD. and TROWSDALE, J ., "You say ITAM and I say ITIM, let's call the
`whole thing off: the ambiguity of imrnunoreceptor signaling," European Journal of
`Immunology 36(7):1646-1653, Wiley-VCH, Germany (2006).
`
`ISHIWATA, K., et al., "Costimulator B7 -DC attenuates strong Th2 responses induced
`by Nippostrongylus brasiliensis," The Journal ofImmunology 184(4):2086-2094, The
`American Association of Immunologists, United States (2010).
`
`PARDOLL, D.M., "The blockade of immune checkpoints in cancer immunotherapy,"
`Nature Reviews Cancer 12:252-264, Macmillan Publishers Limited, England (2012).
`
`SHIN, T., et al., "Cooperative B7-l/2 (CD80/CD86) and B7-DC costimulation of CD4+
`T cells independent of the PD-l receptor," Journal ofExperimental Medicine 198(1) :3 l-
`38, The Rockefeller University Press, United States (2003).
`
`SHIN, T., et al., "In vivo costimulatory role of B7-DC in tuning T helper cell 1 and
`cytotoxic T lymphocyte responses," Journal ofExperimental Medicine 201 :1531-1541,
`The Rockefeller University Press, United States (2005).
`
`SICA, G.L., et al., "B7 -H4, a Molecule of the B7 Family, Negatively Regulates T Cell
`Immunity," Immunity 18:849-861, Cell Press, United States (2003).
`
`
`
`
`
`UniProtKB, "QSIWOO (VSTM4_HUMAN)," accessed at
`htm://www.uniprot.org/uniprot/§281W00, accessed on January 30, 2017, 10 pages.
`
`UniProtKB, "TlNXBS (VSTM4_MOUSE)," accessed at
`htm://www.uniprot.org/uniprot/T lNXBS, accessed on January 30, 2017 , 8 pages.
`
`UniProtKB, "Q727D3 (Q727D3_DESVH)," accessed at
`htm://www.unip_rot.org/unip_rot/§ 2727D3, accessed on January 30, 2017 , 6 pages.
`
`UniProtKB, "Q7TSP5 (VTCN1_MOUSE)," accessed at
`htm://www.unip_rot.org/unip_rot/§ 27TSP5, accessed on January 30, 2017 , 9 pages.
`
`Examiner
`
`Signature
`
`Date
`
`Considered
`
`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance
`and not considered. Include copy of this form with next communication to applicant.
`1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language Translation is attached.
`
`

`

`Substitute for form 1449/PTO
`
`Complete ifKnown
`
`E uivalent of Form PTO/SB/08b
`
`-09)
`
`INFORMATION DISCLOSURE
`
`STATEMENT BY APPLICANT
`(Use as many sheets as necessary)
`
`
`
`NON PATENT LITERATURE DOCUMENTS
`
`Examiner
`
`Include name of the author (in CAPITAL LETTERS), title of the article (when
`appropriate), title of the item (book, magazine, journal, serial, symposium, catalog, etc.),
`date, page(s), volume-issue number(s), publisher, city and/or country where published
`
`VOULGARAKI, D., et al., "Multivalent recombinant proteins for probing functions of
`leucocyte surface proteins such as the CD200 receptor," Immunology 115(3) :337-346,
`Blackwell Publishing Ltd., England (2005).
`
`WANG, S., et al., "Molecular modeling and functional mapping of B7-Hl and B7-DC
`uncouple costimulatory function from PD-l interaction," Journal ofExperimental
`Medicine 197(9): 1083-1091, The Rockefeller University Press, United States (2003).
`
`International Preliminary Report on Patentability and Written Opinion for International
`Application No. PCT/U 815/30472, The International Bureau of WIPO, Switzerland,
`issued on November 15, 2016, 8 pages.
`
`International Search Report for International Application No. PCT/U S15/30472, United
`States Patent and Trademark Office, United States, mailed on October 28, 2015, 5
`
` pages.
`
`503341 lil.d0CX
`
`Examiner
`
`[,1
`
`-
`Meera Natara an/
`
`Date
`
`*EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance
`and not considered. Include copy of this form with next communication to applicant.
`1 Applicant’s unique citation designation number (optional). 2 Applicant is to place a check mark here if English language Translation is attached.
`
`