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`PC'l‘lUSlelll/llfilfiéllll
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`SYSTEMS AND ME'l’flOD-S FUR lND‘UClNG ELECTRIC FIELD PULSES EN A
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`BQDY ORGAN
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`[iltltlll
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`This application claims prierity tn, and the benefit of, US. Pruvisional
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`Application No. 61l225,644,. tiled nn luly l5, 2009, and US Provisional Application No,
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`til/”9,590, filed en May 199 2009, the entireties of both at which applications are hereby
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`incorpnrated herein by reference.
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`Field
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`llltlllZl
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`The disclosed subject matter relates to systems and methods for providing
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`controllable pulse parameter magnetic stimulation that induces electric field pulses in a
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`hudy organ.
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`Backgruund
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`{$983} Magnetic stimulation is a neninvasive tocl for the study ni‘ the human brain
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`and peripheral nerves that is being investigated as a petential therapeutic agent in
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`psychiatry and neurology. When applied to the brain, this technique is commonly referred
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`to as 'l‘ranscranial Magnetic Stimulation (FMS). However, the term “Tit/i3" is Often used
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`to refer to magnetic stimulation of other body organs as well 'l'herefore, the term TMS
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`will be used hereinafter tn refer to magnetic stimulation of the brain or other body organs.
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`llltliltl}
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`in This, a pulsed current sent through a cell pruduces a magnetic'l’ield that
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`induces an electric field in the brain, which can affect neuronal activity. A single ”rs/rs
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`pulse can activate a targeted brain circuit. For example, a 'l'MS pulse delivered tn the
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`meter cortex can result in a twitch of the associated muscles in the hndy. Further; a single
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`TMS pulse can also disrupt neural activity. For example“ a 'l‘lviS pulse delivered to the
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`occipital cortex can mask the perception of a visual stimulus. This allows researchers to
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`probe brain circuits on a millisecond time scale.
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`A train at TMS pulses, referred tn as repetitive TMS (r’l‘MS), can preduce
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`excitatory or inhibitory effects which last heynntl the stimulation interval. Repetitive
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`TMS provides a means to study higher cognitive functions, and it could potentially be
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`used as a therapeutic intervention in psychiatry and neurnlogy.
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`[illliltfi
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`The neural respunse to 'l‘l‘vlS is sensitive tn the parameters of the stimulating
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`TMS pulse. The pulse width (PW), shape (rag, sinuseidal vs. rectangular), and the
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