`
`PCT/U82012/056446
`
`use in inhibiting or attenuating tumor growth in a sub3'eot, wherein the antibody or antigen-
`
`hin-ding fragment thereof is administered in combination with a second therapeutic agent,
`
`wherein the second therapeutic agent is an antibody or antigen-binding fragment thereof that
`
`specifically binds EGFR or HERE.
`
`25. The antibody or antigen-binding fragment of claim 24, wherein the antibody or
`
`antigen-binding fragment comprises the heavy and tight chain CDRs of a HCVRZLCVR amino
`
`acid sequence pair selected from the group consisting of: SEQ ED N05: 2MB, 3826, 34.142,
`
`5058, 66/74, 822’90‘ 981’106, 114.5122, 130/138, 14614 54, 462/170, 1781186, 494/202, 210,1218,
`
`2261234, 2421250, 2581266, 2741282, 2901298, 306/314: 322830, 3381346, 3541362, 370/378‘
`
`3861394, 4021'410, 418K426, 434/442, 450/458, 466K474 and 482490.
`
`25. The antibody or antigen-binding fragment of ctaim 24, wherein the second
`
`therapeutic agent is an antibody or antigen—binding fragment thereof that specifically binds
`
`EGFR.
`
`27. The antibody or antigen-binding fragment of claim 24. wherein the second
`
`therapeutic agent is an antibody or antigen—binding fragment thereof that specifically binds
`
`HERE.
`
`28. The antibody or antigen-binding fragment of ctaim 24, wherein the antibody or
`
`antigen—binding fragment comprises an HCVRILCVR sequence pair having SEQ lD NO:
`306/314 or 3221330.
`
`_.§7_
`
`

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