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`PCT/EP2003/007690
`
`-25...
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`population of cells containing the same recombinant
`
`nucleic acid sequences.
`
`It will be understood that the different heavy
`
`chains according to the invention can be encoded on
`
`separate nucleic acid molecules, but may also be present
`
`on one nucleic acid molecule comprising different regions
`
`encoding said at least three heavy chains. The nucleic
`
`acid molecules usually encode precursors of the light
`
`and/or heavy chains, which when expressed are secreted
`
`from the host cells,
`
`thereby becoming processed to yield
`
`the mature form. These and other aspects of expressing
`
`antibodies in a host cell are well known to those having
`
`ordinary skill in the art.
`
`A “recombinant host cell” as used herein is a cell
`
`comprising one or more so—called transgenes, i.e.
`
`recombinant nucleic acid sequences not naturally present
`
`in said cell. These transgenes are expressed in said host
`
`cell to produce recombinant antibodies encoded by these
`
`nucleic acid sequences, when these cells are cultured
`
`under conditions conducive to expression of said nucleic
`
`acid sequences. The host cell according to the invention
`
`can be present in the form of a culture from a clone that
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`is derived from a single host cell wherein the transgenes
`
`have been introduced. To obtain expression of nucleic
`
`acid sequences encoding antibodies, it is well knOWn to
`
`those skilled in the art that sequences capable of
`
`driving such expression can be functionally linked to the
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`nucleic acid sequences encoding the antibodies.
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`Functionally linked is meant to describe that the nucleic
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`acid sequences encoding the antibody fragments or
`
`precursors thereof is linked to the sequences capable of
`
`driving expression such that these sequences can drive
`
`10
`
`15
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`2.0
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`25
`
`30
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`
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