EP 2 604 625 A1
`
`I. RUBIO ; M. MULLER. DNA-vac-
`POKORNA, D. ;
`cination via tattooing induces stronger humaral and
`cellular immune responses than intramuscular deliv-
`ery supparted by molecular adjuvants. Genet Vac-
`cines Ther., 2008, vol. 6, 4 [0122]
`LADETZ-
`PONSEL D; NEUGEBAUER J ;
`Kl-BAEHS K ; TISSOT K. High affinity, developability
`and functional size: the holy grail of combinatorial an—
`tibody library generation. Molecules, 2011, vol. 18,
`3675-700 [0122]
`QUAAK, 5.G. et al. GMP production of prRMA lT
`for vaccination against melanoma in a phase l clinical
`trial. Eur J Pharm Biopharm, 2008, vol. 70, 429-38
`[0122]
`RAVN U ; GUENEAU F ; BAERLOCHER L ;OSTE-
`RAS M ;DESMURS M ;MALINGE P ;MAGISTREL-
`Ll G ; FARINELLI L ; KOSCO-VILBOIS MH ;
`FISCHER N. By-passing in vitro screening-next gen-
`eration sequencing technologies applied to antibody
`display and in silico candidate selection. Nucleic Ac-
`ids Res, 2010, vol. 38, e193 [0122]
`REDDY ST; GE X; MIKLOS AE; HUGHES RA;
`KANG SH; HOI KH ; CHRYSOSTOMOU C; HU-
`NICKE-SMITH SP; IVERSON BL; TUCKER PW.
`Monoclonal antibodies isolated without screening by
`analyzing the variable-gene repertoire of plasma
`cells. Nat Biotechnol, 2010, vol. 28, 965—9 [0122]
`REDDY ST; GEORGIOU G. Systems analysis of
`adaptive immunity by utilization of high-throughput
`technologies. Curr Opin Biotechnol, 2011, vol. 4,
`584—9 [0122]
`RUULS SR ; LAMMERTS VAN BUEREN JJ ; VAN
`DE WINKEL JG ; PARREN PW. Novel human anti-
`body therapeutics: the age of the Umabs. Biotechnol
`J., 2008, vol. 3, 1157—71 [0122]
`;
`SCHAFFITZEL, C. ; HANES, J. ; JERMUTUS, L.
`PLUCKTHUN, A. Ribosome display: an in vitro meth-
`od for selection and evolution of antibodies from li-
`braries.
`J.
`lmmunol. Methods, 1999, vol. 231,
`119-135 [0122]
`SCHMIDLIN H; DIEHL SA ; BLOM B. New insights
`into the regulation of human B—cell differentiation.
`Trends lmmunol., 2009, vol. 30, 277-85 [0122]
`SHAPIRO-SHELEF, M. ;CALAME, K. Regulation of
`plasma-cell development. Nat. Rev. lmmunol., 2005,
`vol. 5, 230-242 [0122]
`SMITH K ; GARMAN L; WRAMMERT J ; ZHENG
`N-Y ; CAPRA JD ; AHMED R ; WILSON PC. Rapid
`generation offully human monoclonal antibodiesspe—
`cific to a vaccinating antigen. Nat Protoc, 2009, vol.
`4, 372-384 [0122]
`STEVENSON, F.K. DNA vaccines to attack cancer.
`Proc Natl Acad Sci, 2004, vol. 101 (2), 14646-52
`[0122]
`
`50
`
`STORY CM; PAPA E; HU c-CA; RONAN JL;
`HERLIHY K; PLOEGH HL ; LOVE JC. Profiling an-
`tibody responses by multiparametric analysis of pri-
`mary B cells. Proc Natl Acad Sci U S A, 2008, vol.
`105, 17902—17907 [0122]
`TAJIRI K; KISHI H; TOKIMITSU Y; KONDO S;
`OZAWAT ; KINOSHITA K ;JIN A ; KADOWAKI S;
`SUGIYAMA T; MURAGUCHI A. Cell—microarray
`analysis of antigen-specific B-cells: single cell anal-
`ysis of antigen receptor expression and specificity.
`Cytometry. 2007, vol. 71, 961-967 [0122]
`TILLER T; MEFFRE E; YURASOV S ; TSUIJI M;
`NUSSENZWEIG MC; WARDEMANN H. Efficient
`generation of monoclonal antibodies from single hu-
`man B cells by single cell RT-PCR and expression
`vector cloning. J Immunol Methods, 2008, vol. 329,
`112-124 [0122]
`TOKIMITSU Y; KISHI H; KONDO S; HONDA R;
`TAJIRI K ; MOTOKI K ; OZAWAT ; KADOWAKI S ;
`OBATA T; FUJIKI S et al. Single lymphocyte anal—
`ysis with a microwell array chip. Cytometry, 2007, vol.
`71, 1003-1010 [0122]
`THROSBY, M.
`; GEUIJEN, C.; GOUDSMIT, J. ;
`BAKKER, A. Q. ; KORIMBOCUS, J. ; KRAMER, R.
`A. et al. Isolation and characterization ofhuman mon-
`oclonal antibodiesfrom individuals infected with West
`
`Nile virus. J. Virol., 2006, vol. 80, 6982—6992 [0122]
`TRAGGIAI, E.; BECKER, S.; SUBBARAO, K.;
`KOLESNIKOVA, L.
`; UEMATSU, Y. ; GISMONDO,
`M.R.; MURPHY, B.R.; RAPPUOLI, R.; LANZA-
`VECCHIA, A. An efficient method to make human
`monoclonal antibodies from memory B cells: potent
`neutralization of SARS coronavirus. Nat. Med, 2004,
`vol. 10, 871 [0122]
`; DAVIS, H.L.
`WEERATNA, R. ; COMANITA, L.
`CPG ODN allows lower dose of antigen against hep-
`atitis B surface antigen in BALB/c mice. Immunol. Cell
`Biol., 2003, vol. 81, 59 [0122]
`WHITTINGTON, P.J. DNA vaccination controls
`Her-2+ tumors that are refractory to targeted thera-
`pies. Cancer Res, 2008, vol. 68, 7502-11 [0122]
`WRAMMERT, J. et al. Rapid cloning of high—affinity
`human monoclonal antibodies against influenza vi-
`rus. Nature, 2008, vol. 453, 667-671 [0122]
`WU, C. ;HUAYING ;GRINNELL, C. ;BRYANT, S. ;
`MILLER, R. Simultaneous targeting of multiple dis-
`ease mediators by a dual-variable-domain immu-
`noglobulin. Nature Biotechnology, 2007, vol. 25,
`1290—1297 [0122]
`YU, X. ; MCGRAW, P.A. ; HOUSE, F.S. ; CROWE
`JR., J.E. An optimized electrofusion-based protocol
`for generating virus-specific human monoclonal an-
`tibodies. J. Immunol. Methods, 2008, vol. 336, 142
`[0122]
`ZUBLER RH ;WERNER-FAVRE C ;WEN L ;SEKI-
`TA K ; STRAUB C. Theoretical and practical aspects
`of B—cell activation: murine and human systems. lm—
`munol Rev., 1987, vol. 99, 281-99 [0122]
`
`