PTO/AiA/14 (12-13)
`Approved for use through 01/31/2014. OMB Mitt-00152
`US, Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act M1995, no persons are required to respond to a coiieciion of information uniess it contains a veiid OMB wniroi number.
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`Appirca’nen Sate Sheet 37 CFR 1.576 ~
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`.
`_
`Appiiceticn Number
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`14/861989
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`ddeument may be printed and inciuded in a paper flied ramification.
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`Tiiie 0i: inventien
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`METHODS AND SYSTEMS FOR DETECTING GENETiC VARIANTS
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`The appiicaiion data sheet is part oftite provisionat or ridnprovisicnai eppiicatidn for which it is being submitted The foiicwirig term centeins the
`ethnographic data arranged in a format specified by the United States Patent and Trademark Offce es cuiiined in 37 CPR 1.76
`This document may be compieted eiectroniceiiy and submitted to the Office in eiectrcnie format using the Eiectrdnic Fiiirig System (EFS) or the
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`Secrecy (Enter 3? CFR 52
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`: Pcrtiens or aii cfthe appiiceticrr associated with this Appiicetidn Data Sheet may teii under a Secrecy Greer pursuant to
`' 37 CFR 52 (Paper fliers cniy. Appiicaticns that fail under Secrecy Order may not be tried eiectrcniceiiy.)
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`inventer intermetien:
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`inventer
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`t
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`Legei Name
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`-———-
`Residence information (Seieot Gite)
`fie) US Residency 0 Non US Residency 0 Active US Miiitery Service
`
`Maiiing Address of inventer:—
`
`——
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`inventor
`. Legei Name
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`2
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`.
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`Residence intermatien (Seiect One)
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`(a?) US Residency
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`(:9 Non US Residency 0 Active US Vite“; Service
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`
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`Matting Address at inventor:
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`Address 1
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`2181 Gemini) 3 Les Germs
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`Legei Name
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`Residence information (Seieot Gite) Q US Residency 0 Non US Residency 0 Active US Miiitery Service
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`EFS Web 2.2.10
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`

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`PTO/AiA/14 (12-13)
`Approved for use through 01/31/2014. OMB {Jodi-00152
`U.S, Patent and Trademark Office; U55. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act ot1995, no persons are required to respond to a ooiieotion of information uniess it contains a vaiid OMB controi nurnher
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`Apntree‘tren Beta Sheet 3'? CFR 1."?6
`
`_
`_
`Anniioation Number
`
`~
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`14/861 989
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`~
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`Tithe Of invention
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`METHODS AND SYSTEMS FOR DETECTING GENETiC VARlANTS
`
`Statelerovinee
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`Country of Residence
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`generated within this term by seiecting the Add button.
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`Matting Address of inventor:
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`Address 1
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`2000 Willow Sggrings Road
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`City
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`More” i-tili
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`State/Province
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`Ait
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`inventors Must Be Listed — Additionat
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`inventor information hieeks may be
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`dorresnendenee information:
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`Enter either Customer Number or eomniete the Correspondence information section betow.
`For further information see 3? GFR 1.153(at.
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`{3 An Address is being provided for the correspondence information of this appiieation,
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`Customer Number
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`115823
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`Emaii Address
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`patentdocket@wsgr.oom
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`Anntieetten intermation:
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`Titie 0f the invention
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`METHODS AND SYSTEMS FOR DETECTENG GENETIC VAREANTS
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`Attorney Becket Number— Smait Entity Status Ctaimed
`Application Type
`Nonprovisionat
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`{3
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`Subject Matter
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`Tote! Number of {Brewing Sheets {it any)
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`11
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`Suggested Figure for Puntieation {it any)
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`flied appiication
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`Fiiing By Reference :
`
`Oniy compete this section when fiiing an aopiication by reference under 35 ti.S.C. i 1 He) and 37 CFR i .S7iai. Do not compiete this. section if
`zippiication papers; inciuding a specification and anydrawings are being fiied. Any domestic benefit or foreign priority information must be
`provided in the appropriate section(s) beiow (Le, "Domestic Benefit/’i‘iationai Stage information" and ”Foreign Priority information").
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`For the purposes; ofa fiiing date under 3.7 CFR i.53(b,‘-, the description and any drawings ofthe present appiication are replaced by this.
`reference to the nreviousiy fiieci application, subject to conditions and requirements; of 37 CFR i.57(zt).
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`Application nurnherof the nreviousiy
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`Puhiieetien tnterrnation:
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`{3 Request Earty Puhiioation (Fee required at time of Request 37 CFR t.219)
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`pubiieation at eighteen months after tiiing.
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`Request NOT if.) Puhiieh. i hereby request that the attached appiioatiori not be pubtished under
`35 USED. 1226;») and certify that the invention diseiosed in the attached anniioation has not and wit! not be the
`subject of an appiication tiied in another country, or under a muitiiaterai internationai agreement, that requires
`
`

`

`PTO/AiA/t 4 (12-13)
`Approved for use through 01/31/2014. OMB Mitt-00152
`U.S, Patent and Trademark Ottioa; U55. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of1995, no persons are required to respond to a ooilectiori of information unless it contains a valid OMB control number
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`Appiiea‘tion Bate Sheet 3'? CFR 1."?6
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`_
`_
`Appiioation Number
`
`~
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`~
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`14/861 989 Titian of invention
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`METHODS AND SYSTEMS FOR DETECTING GENETiC VARlANTS
`
`Representative information:
`
`Representative information snouid he provided for aii practitioner‘s having a power of attorney in the appiication. Providing
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`Either enter Customer Number or compiete the Representative Name section below.
`if both sections are oompieted the customer
`Numberwiii he used forthe Representative information during processing,
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`Customer Number
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`Piease Seieot One:
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`'
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`Ci .
`
`'
`
`~
`
`'
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`‘ "i
`
`i
`
`‘
`
`titeci Recs it"iiO’i (37 CFR 11,9)
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`flomestio Benetttihiationai Stage information:
`This section aiiows for the appiicant to either ciaim benefit under 135 USE; i 19(e), 120, 121, or 3650:) or indicate Nationai Stage
`entry from a PCTappiication. Providing this information in the appiication data sheet constitutes the specific reference required
`by 35 U,S.C. i 1%?) or 120, and 37 CFR 178“
`When referring to the current appiication, piease leave the appiication number biank.
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`PriorAppiioation Status
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`Pending
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`Appiioation Number
`Continuity Type
`Prior Appiioation Number
`Filing Date (YWY—MMDD)
`————
`Prior Appiioation Status
`Expired
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`Access (Bodei (if appiicahie)
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`Appiioation Number
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`Continuity Type
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`Prior Appiioation Number
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`Fiiing Date (YYYY—MM—DD)
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`PCT/U320“: iii/072383
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`Claims benefit of provisionai
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`61948569
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`2014vG3—05
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`PriorAppiioation Status
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`Expired
`
`Appiication Number
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`Continuity Type
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`Prior Appiication Number
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`Fiiing Dateft’Y‘r’YHit/EM DD)
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`PCT/U820“: 4/672383
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`Claims oenetit of proviSionai
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`51921456
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`2019" H1228
`
`Additionai Domestic Benefit/Nationai Stage Data may be generated within this form
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`Foreign Priority information:
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`This section aiiows fortne applicant to ciaim priority to a foreign appiication. Providing this information in the appiication data sheet
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`constitutes the oiaim for priority as required by 35 USC, 11%)) and 37 CFR 1.5503) When priority is ciaimed to a foreign appiioation
`that is eiigibie for retrievai under the priority document exchange program (P’DX)i the information wiii he used by the Office to
`automaticaiiy attempt retrievai pursuant to 37 CPR t.55(n)(1) and (2). Underthe PBX program, appiieant hears the uitimate
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`responsibiiity for ensuring that a copy ofthe foreign appiication is received by the Office from the participating foreign inteiiectuai
`
`property office, or a certified copy otthe foreign priority appiication is tiied, within the time period specified in 37 CPR i.55(g)(i).
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`Appiication Number
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`Countryi
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`Fiiing Date (WW-MMMDD)
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`

`

`PTO/AiA/14 (12-13)
`Approved for use through 01/31/2014. OMB Mitt-00152
`U.S, Patent and Trademark Office; U55. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995. no persons are required to respond to a coiiection of information uniess it contains a vaiid OMB coritroi riurnher.
`
`Appiica‘tion Bate Sheet 3'? CFR 1."?6
`
`_
`_
`Appiication Number
`
`~
`
`14/861989
`
`~
`
`Tithe Of invention
`
`METHODS AND SYSTEMS FOR DETECTING GENETiC VARiANTS
`
`Add button.
`
`. Additionai Foreign Priority Data may he generated within this form by seiecting the
`
`Statement under 3"? (FR L55 or 1.?8 for are {First inventor to Fife} Transition
`notifications
`
`This appiication (1) oiaims priority to orthe heneiit ofan appiioatioh tiied before March 16, 2013 and (2) aiso
`contains, or contained at anytime, a ciairn to a ctaimed invention that has an effective fiiing date on or after March
`to, 2913.
`NOTE: By providing this statement under 3? CFR 1.55 cr1.78, this appiication, with a fiiing date on or after March
`
`16, 20i3, wiii he examined under the first inventor to fiie provisions of the AiA.
`
`E]
`
`Authorization to Permit Access:
`
`Authorization to Permit Access to the instant Appiication by the Participating Offices
`
`if checked, the undersigned hereby grants the USPTO authority to provide the European Patent Office (EPO),
`the Japan Patent Office (JPO), the Korean inieiieciuai Property Gftice (KiPO), the World inteiiectuai Property Office (WiPO),
`and any other inteiiectuai property offices in which a foreign appiication claiming priority to the instant patent appiication
`is filed access to the instant patent appiication. See 37 CPR 114(0) and (h). This box should not he checked if the appiicant
`does not wish the EPO, JPO, KiPO. WiPO. or other inteiiectuai property office in which a foreign appiication ciairning priority
`to the instant patent appiioation is fiied to have access to the instant patent appiication.
`
`in accordance with 37 CFR t.t4(c), access may be provided to information concerning the date 0 f fiiing this Authorization.
`
`in accordance with 3? CFR 1.1400(3), access wiii he provided to a copy ofthe instant patent appiication with respect
`to: i) the instant patent appiication~as~fiied; 2) any foreign appiicaiion to which the instant patent appiication
`ciaims priority under 35 USC. 119(a)—(d) it a copy of the foreign appiicaiion that satisfies the certified copy requirement of
`37 CFR 1.55 has been fiied in the instant patent appiication; and 3) any US. appiication—as—fiied from which benefit is
`sought in the instant patent appiication.
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`Appiicant information:
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`Providing assignment information in this section does not substitute for compiiance with any requirement of part 3 of Titie 37 of CPR
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`to have an assignment recorded py the Office.
`
`EL. Tito Web 2.2.10
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`

`PTO/AiA/t 4 (12-13)
`Approved for use through 01/31/2014. OMB ossi-oosz
`U.S. Patent and Trademark Cities; U55. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act oi1995, no persons are required to respond to a ooileotion or" information nniess it contains a valid OMB controi nurnher
`
`Apniioa‘hon Beta Sheet 3'? CFR 1."?6
`
`_
`_
`Apniioation Number
`
`~
`
`14/861 989
`
`~
`
`
`
`Titte of invention
`
`METHODS AND SYSTEMS FOR DETECTING GENETiC VARlANTS
`
`Apoiieant
`
`’i
`
`ifthe applicant is the inventor (or the remaining joint inventor or inventors under 37 CPR 1.45), this section shouid not be oornpieted.
`The information to be provided in this section is the name and address otthe iegai representative who is the aopiioant under 37 CFR
`1.43; or the name and address of the assignee, person to whom the inventor is under an obligation to assign the invention, or person
`who otherwise shows sufficient proprietary interest in the matter who is the appiicant under 37 CFR 1.46. it the aopiioant is an
`appiioant under 37 CPR 1.46 (assigns-e, person to whom the inventor is obligated to assign, or person who otherwise shows sufficient
`proprietary interest) together with one or morejoint inventors, then thejoint inventor or inventors who are aiso the aopiieant should be
`identified in this section.
`
`C) Legai Representative under 35 USS. it?
`
`C)
`
`Joint inventor
`
`C) Person to whom the inventor is obiigated to assign.
`
`C)
`
`Person who shows sufficient proprietary interest
`
`it appiioant is the iegai representative, indicate the authority to hie the patent appiioation, the inventor is:
`
`a
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`
`
`Name oithe Deceased or Legaiiy inoapaoitated inventor
`tithe Appiioant is an Gr’ganization check here.
`13}
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`Organization Name
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`Guardant i—ieaith. ino.
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`Matting Address information For Appiicant:
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`2686 iViiddiefieid Rd, Suite D
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`Address 1
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`Address :2
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`mi
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`Assignee information inoinding itionifiipniioant Assignee information:
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`Providing assignment information in this section does not subsitute tor oompiianoe with any requirement of part 3 of Titie 37 of CFR to
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`patent application puhiioation. tithe Assignee or NonuAppiicant Assignee is an Organization check here.
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`pupiication as an appiioaht. For an assignee-appiioant. oompiete this section oniy it identification as an assignee is also desired on the
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`

`

`PTO/AiA/14 (12-13)
`Approved for use through 01/31/2014. OMB Mitt-00152
`U.S, Patent and Trademark Office; U55. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a ooileetion of information unless it contains a valid OMB control number
`
`A E"
`t'
`ion E051
`m}
`
`B t Sh
`a e
`
`ee
`
`t 3? CFR 1 T6 Attorney Docket Number
`.
`Apniioetion Number
`
`~
`
`42534—708301
`14/861 989
`
`~
`
`Tithe Of invention
`
`METHODS AND SYSTEMS FOR DETECTING GENETiC VARlANTS
`
`seieoting the Add button.
`
`Maiiing Address information For Assignee ineiuding Nen—Anniieant Assignee:
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`Emaii Address
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