WHAT IS CLAIMED IS:
`
`1.
`
`A method comprising,
`
`providing target DNA molecules within a plurality of reaction volumes; and
`
`fragmenting the target DNA molecules within the reaction volumes.
`
`2.
`
`The method of claim 1, wherein the provided target DNA molecules are
`
`target DNA fragments.
`
`3.
`
`The method of claim 2, wherein the target DNA fragments are
`
`chromosomal fragments.
`
`4.
`
`The method of claim 2, wherein the providing comprises fragmenting a
`
`DNA sample to generate the target DNA fragments.
`
`5.
`
`The method of claim 1, wherein said fragmenting comprising contacting
`
`the provided target DNA molecules in the reaction volumes with an enzyme that cleaves DNA.
`
`6.
`
`7.
`
`8.
`
`emulsion.
`
`The method of claim 5, wherein the enzyme is a restriction enzyme.
`
`The method of claim 1, wherein the reaction volumes are droplets.
`
`The method of claim 7, wherein the droplets are contained within an
`
`9.
`
`The method of claim 1, wherein the reaction volumes are microcapsules.
`
`10.
`
`The method of claim 2, wherein the target DNA fragments are less than 10
`
`kilobases (kb) in length.
`
`11.
`
`The method of claim 2, wherein the providing comprises fragmenting the
`
`target DNA molecules outside the reaction volumes to form the target DNA fragments.
`
`12.
`
`The method of claim 1, wherein the reaction volumes are less than 1 uL,
`
`or less than 100 nL in volume.
`
`13.
`
`The method of claim 1, wherein the m plurality of reaction volumes
`
`comprise at least 1,000 or at least 10,000 reaction volumes.
`
`73
`
`

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