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`14/493,264
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`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`Pages, Columns, Lines, Where
`NameofPatenteeor
`Kind
`Cite
`Examiner
`Relevant Passages or Relevant
`A licantofcited Document
`Issue Date
`Code
`Patent Number
`No
`lnitial*
`Fi ures A oear
`pp
`I
`
`
`U.S. PATENTS
`
`05-06-1980
`08-11-1981
`
`
`A2
`
`4,201,691
`
`Asheretal.
`
`03-20-1984
`01-13-1987
`
`
`A5
`
`4,437,975
`
`Gillesie etal.
`
`11-28-1989
`08-14-1990
`
`
`A8
`
`4,883,750
`
`Whitele etal.
`
`10-08-1991
`01-05-1993
`
`
`A11
`
`5,055,390
`
`Weaver et al.
`
`09-07-1993
`1244-1993
`
`
`A14
`
`5,242,794
`
`Whitele etal.
`
`09-06-1994
`04-25-1995
`
`
`A17
`
`5,344,930
`
`Riess etal.
`
`A20
`
`5,422,277
`
`06-06-1995
`06-20-1995
`
`Connell etal.
`
`12-19-1995
`02-27-1996
`
`
`A23
`
`5,476,930
`
`Letsineretal.
`
`Dave etal.
`
`
`
`09-10-1996
`09-10-1996
`
`12-17-1996
`Zanzucchi et al.
`12-24-1996
`Wildinetal.
`01-14-1997
`
`
`A26
`
`5,554,517
`
`A29
`
`5,587,128
`
`02-24-1998
`04-07-1998
`
`
`A32
`
`5,720,923
`
`Haffetal.
`
`07-28-1998
`10-27-1998
`
`
`A35
`
`5,786,146
`
`Herman etal.
`
`A38
`
`5,861,245
`
`01-19-1999
`02-02-1999
`
`Mcclelland etal.
`
`02-16-1999
`06-15-1999
`07-27-1999
`
`08-31-1999
`A43
`5,945,334
`Besemer eta l.
`
`A41
`
`5,912,945
`
`Landegren et al.
`Da Silva etal.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
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`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
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`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`Pages, Columns, Lines, Where
`NameofPatenteeor
`Kind
`Cite
`Examiner
`Relevant Passages or Relevant
`A licantofcited Document
`Issue Date
`Code
`Patent Number
`No
`lnitial*
`Fi ures A oear
`pp
`I
`
`
`U.S. PATENTS
`
`11-09-1999
`11-30-1999
`
`
`A45
`
`5,980,936
`
`Krafftetal.
`
`03-28-2000
`05-02-2000
`
`05-16-2000
`Davey et al.
`10-03-2000
`Woudenberetal.
`10-10-2000
`
`
`A48
`
`6,042,709
`
`A51
`
`6,126,899
`
`Parce etal.
`
`
`
`11-07-2000
`11-14-2000
`
`
`A54
`
`6,143,504
`
`Das etal.
`
`01-16-2001
`01-23-2001
`
`
`A57
`
`6,175,669
`
`Colston etal.
`
`01-30-2001
`03-13-2001
`
`
`A60
`
`6,180,349
`
`Ginzineretal.
`
`A63
`
`6,210,879
`
`04-03-2001
`05-22-2001
`
`Melonietal.
`
`07-10-2001
`07-10-2001
`
`
`A66
`
`6,258,540
`
`Loetal.
`
`08-28-2001
`10-16-2001
`
`
`A69
`
`6,281,254
`
`Naka'imaetal.
`
`03-19-2002
`05-07-2002
`
`05-21-2002
`Brown et al.
`06-25-2002
`Bur etal.
`08-27-2002
`
`
`A72
`
`6,357,907
`
`A75
`
`6,410,276
`
`Cleveland etal.
`
`10-15-2002
`12-03-2002
`
`
`A78
`
`6,466,713
`
`Everettetal.
`
`A81
`
`6,494,104
`
`A83
`A84
`
`6,524,456
`
`12-17-2002
`01-21-2003
`02-18-2003
`02-25-2003
`04-01-2003
`
`A86
`6,551,841
`04-22-2003
`Wilding et al.
`
`Kawakita etal.
`
`Evans
`Ramse etal.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`Pages, Columns, Lines, Where
`NameofPatenteeor
`Kind
`Cite
`Examiner
`Relevant Passages or Relevant
`A licantofcited Document
`Issue Date
`Code
`Patent Number
`No
`lnitial*
`Fi ures A oear
`pp
`I
`
`
`U.S. PATENTS
`
`05-06-2003
`06-10-2003
`
`
`A88
`
`6,558,928
`
`Landeren
`
`07-22-2003
`08-05-2003
`
`
`A91
`
`6,596,493
`
`Reeves etal.
`
`10-28-2003
`10-28-2003
`
`
`A94
`
`6,637,463
`
`Lei etal.
`
`12-16-2003
`12-16-2003
`
`
`A97
`
`6,663,619
`
`Odrichetal.
`
`06-22-2004
`07-27-2004
`
`
`A100
`
`6,753,147
`
`Voelstein etal.
`
`09-14-2004
`10-26-2004
`
`
`A103
`
`6,790,328
`
`Jacobson etal.
`
`A106
`
`6,833,242
`
`12-21-2004
`02-22-2005
`
`Quakeetal.
`
`05-31-2005
`06-14-2005
`
`
`A109
`
`6,900,021
`
`Harrisonetal.
`
`09-27-2005
`10-11-2005
`
`11-01-2005
`Enzelberger et al.
`11-15-2005
`Shuber
`03-07-2006
`
`
`A112
`
`6,949,176
`
`A115
`
`6,964,846
`
`Vacca etal.
`
`
`
`05-09-2006
`05-30-2006
`
`
`A118
`
`7,041,481
`
`Anderson etal.
`
`07-25-2006
`08-15-2006
`
`
`A121
`
`7,081,336
`
`Baoetal.
`
`A124
`
`7,118,910
`
`A127
`
`7,141,537
`
`10-10-2006
`10-31-2006
`11-21-2006
`11-28-2006
`03-20-2007
`
`A129
`7,198,897
`04-03-2007
`Wangh et al.
`
`Uneretal.
`
`Griffiths et al.
`Audenaertetal.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`Pages, Columns, Lines, Where
`NameofPatenteeor
`Kind
`Cite
`Examiner
`Relevant Passages or Relevant
`A licantofcited Document
`Issue Date
`Code
`Patent Number
`No
`lnitial*
`Fi ures A oear
`pp
`I
`
`
`U.S. PATENTS
`
`07-17-2007
`08-07-2007
`
`
`A131
`
`7,244,567
`
`Chenetal.
`
`09-11-2007
`09-11-2007
`
`
`A134
`
`7,268,167
`
`Hi-uchietal.
`
`10-09-2007
`11-13-2007
`
`
`A137
`
`7,279,146
`
`Nassefetal.
`
`12-11-2007
`12-25-2007
`
`
`A140
`
`7,306,929
`
`l-natovetal.
`
`01-29-2008
`02-19-2008
`
`
`A143
`
`7,323,305
`
`Leamon etal.
`
`05-06-2008
`05-06-2008
`
`
`A146
`
`7,368,233
`
`Shuberetal.
`
`A149
`
`7,423,751
`
`09-09-2008
`09-09-2008
`
`Hairston etal.
`
`03-31-2009
`07-28-2009
`
`
`A152
`
`7,510,829
`
`Fahametal.
`
`09-29-2009
`11-17-2009
`
`
`A155
`
`7,595,195
`
`Lee etal.
`
`11-24-2009
`12-08-2009
`
`
`A158
`
`7,622,280
`
`Holli-eretal.
`
`04-20-2010
`05-18-2010
`
`
`A161
`
`7,700,323
`
`Willisetal.
`
`07-13-2010
`08-17-2010
`
`
`A164
`
`7,754,428
`
`Loetal.
`
`A167
`
`7,790,393
`
`A170
`
`7,807,920
`
`66582559V.1
`
`
`
`09-07-2010
`09-21-2010
`09-28-2010
`10-05-2010
`10-12-2010
`
`10-12-2010
`A172
`7,811,757
`Shuber
`
`Lamichevetal.
`
`Anderson et al.
`Linkeetal.
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`_—
`_—
`Attorney Docket Number
`94868-916163 (107220US)
`
`U.S. PATENTS
`
`Examiner
`Initial*
`
`Cite
`No
`
`Patent Number
`
`Kind
`Code
`I
`
`Issue Date
`
`Name of Patentee or
`A Iicant of cited Document
`pp
`
`Pages, Columns, Lines, Where
`Relevant Passages or Relevant
`Fi ures A oear
`
`Berka et al.
`11-30-2010
`7,842,457
`A174
`__———_—
`__——- Hiddessen et al. —
`
`
` .
`
`Examiner
`.
`.
`*
`Initial
`
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`.
`.
`.
`Kind
`Pages, Columns, Lines, Where
`Cite
`Publication
`Code
`Relevant Passages or Relevant
`No
`Number
`1
`.
`Figures Appear
`
`.
`.
`Publication Date
`
`Name of Patentee or
`.
`.
`Applicant of Cited Document
`
`Appln filed
`
`
`A1 0209/201213/385,277A177 Regan et al.
`
`
`--_———
`A179
`2002/0021866
`A1
`02-21-2002
`Everettetal.
`__———
`
`
`A182
`
`2002/0068357
`
`A1
`
`06-06-2002
`
`Mathies etal
`
`__———
`
`A184
`2002/0141903
`A1
`10-03-2002
`Parunak etal.
`A185
`2002/0142483
`A1
`10-03-2002
`Yao etal.
`
`__———
`
`
`A188
`
`2002/0195586
`
`A1
`
`12-26-2002
`
`Auslanderetal
`
`__———
`
`A190
`2003/0003054
`A1
`01-02-2003
`McDonald etal
`A191
`2003/0003441
`A1
`01-02-2003
`Colston etal.
`
`__——_—
`
`
`A194
`
`2003/0027244
`
`A1
`
`02-06—2003
`
`Colston etal
`
`__————
`
`A197
`
`2003/0049659
`
`A1
`
`03-13-2003
`
`Laoidusetal.
`
`__-_——
`_——__—
`_———
`_———
`_———
`_——__—
`_——_——
`_———
`_ A206
`2004/0068019
`A1
`04-08-2004
`Hiuchietal. —
`1
`_ A207
`2004/0074849
`A
`04-22-2004 _—
`
`A208
`2004/0101835
`A1
`05-27-2004
`Willis et al.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`_—
`_—
`Attorney Docket Number
`94868—916163 (107220US)
`
`
`
`_———
`_—————
`_———
`_———
`
`
`A214
`
`2005/0026180
`
`A1
`
`02-03-2005
`
`Willisetal.
`
`_———
`
`
`A217
`
`2005/0064460
`
`A1
`
`03-24-2005
`
`Hollioeretal.
`
`_—————
`
`
`A220
`
`2005/0112541
`
`A1
`
`05-26-2005
`
`Durack etal.
`
`_———
`
`
`A223
`
`2005/0158739
`
`A1
`
`07-21-2005
`
`Jeddeloh etal.
`
`_———
`
`
`A226
`
`2005/0221279
`
`A1
`
`10-06-2005
`
`Carter etal.
`
`_——_——
`
`
`A229
`
`2005/0239192
`
`A1
`
`10-27-2005
`
`Nasarabadietal.
`
`_———
`
`
`A232
`
`2005/0282206
`
`A1
`
`12-22-2005
`
`Michael Corbett etal.
`
`_———
`
`
`A235
`
`2006/0073511
`
`A1
`
`04-06-2006
`
`Keith etal.
`
`_——-——
`
`
`A238
`
`2006/0079583
`
`A1
`
`04-13-2006
`
`Hiouchietal.
`
`_——-——
`
`
`A241
`
`2006/0094108
`
`A1
`
`05-04-2006
`
`Yoder etal.
`
`_———
`
`
`A244
`
`2006/0188463
`
`A1
`
`08-24-2006
`
`Kim etal.
`
`_———
`
`
`A247
`
`2006/0292585
`
`A1
`
`12-28-2006
`
`Nauti aletal.
`
`_———
`
`
`A250
`
`2007/0048756
`
`A1
`
`03-01-2007
`
`Mei etal.
`
`_———
`
`
`A253
`
`2007/0172873
`
`A1
`
`07-26-2007
`
`Brenneretal.
`
`_———
`
`A255
`2007/0195127
`A1
`08-23-2007
`Ahn etal.
`A256
`2007/0196397
`A1
`08-23-2007
`Toriietal.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`_—
`_—
`Attorney Docket Number
`94868-916163 (107220US)
`
`
`
`_———
`_———
`_———
`_———
`
`
`A262
`
`2007/0258083
`
`A1
`
`11-08-2007
`
`Heuelletal.
`
`_———
`
`
`A265
`
`2008/0003142
`
`A1
`
`01-03-2008
`
`Linketal.
`
`_———
`
`
`A268
`
`2008/0090244
`
`A1
`
`04-17-2008
`
`Knauetal.
`
`_———
`
`
`A271
`
`2008/0138815
`
`A1
`
`06-12-2008
`
`Brown etal.
`
`_———
`
`
`A274
`
`2008/0160525
`
`A1
`
`07-03-2008
`
`Brown etal.
`
`_———
`
`
`A277
`
`2008/0169184
`
`A1
`
`07-17-2008
`
`Brown etal.
`
`_———
`
`
`A280
`
`2008/0171325
`
`A1
`
`07-17-2008
`
`Brown etal.
`
`_———
`
`
`A283
`
`2008/0171380
`
`A1
`
`07-17-2008
`
`Brown etal.
`
`_———
`
`
`A286
`
`2008/0214407
`
`A1
`
`09-04-2008
`
`Remacle etal.
`
`_———
`
`
`A289
`
`2008/0268436
`
`A1
`
`10-30-2008
`
`Duan etal.
`
`_———
`
`
`A292
`
`2008/0280865
`
`A1
`
`11-13-2008
`
`Tobita
`
`_———
`
`
`A295
`
`2009/0004646
`
`A1
`
`01-01-2009
`
`Schusteretal.
`
`_———
`
`
`A298
`
`2009/0026082
`
`A1
`
`01-29-2009
`
`Rothbero etal.
`
`_———
`
`
`A301
`
`2009/0035770
`
`A1
`
`02-05-2009
`
`Mathies etal.
`
`_———
`
`A303
`2009/0061428
`A1
`03-05-2009
`McBride etal.
`A304
`2009/0068170
`A1
`03-12-2009
`Weitz etal.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
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`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`_—
`_—
`Attorney Docket Number
`94868—916163 (107220US)
`
`
`
`_———
`_———
`_—————
`_———
`
`
`A310
`
`2009/0131543
`
`A1
`
`05-21-2009
`
`Weitz etal.
`
`_———
`
`
`A313
`
`2009/0176271
`
`A1
`
`07-09-2009
`
`Durack etal.
`
`_———
`
`
`A316
`
`2009/0217742
`
`A1
`
`09-03-2009
`
`Chiu etal.
`
`_———
`
`
`A319
`
`2009/0239308
`
`A1
`
`09-24-2009
`
`Dube etal.
`
`_——-——
`
`
`A322
`
`2009/0325184
`
`A1
`
`12-31-2009
`
`Woudenbero etal.
`
`_———_—
`
`
`A325
`
`2010/0009360
`
`A1
`
`01-14-2010
`
`Rosell Costa et al.
`
`_———
`
`
`A328
`
`2010/0041046
`
`A1
`
`02-18-2010
`
`Chiu etal.
`
`_———
`
`
`A331
`
`2010/0069263
`
`A1
`
`03-18-2010
`
`Shendureetal.
`
`_—————
`
`
`A334
`
`2010/0092981
`
`A1
`
`04-15-2010
`
`Shuber
`
`_———
`
`
`A337
`
`2010/0137163
`
`A1
`
`06-03-2010
`
`Link etal.
`
`_———
`
`
`A340
`
`2010/0248385
`
`A1
`
`09-30-2010
`
`Tan etal.
`
`_———
`
`
`A343
`
`2010/0256015
`
`A1
`
`10-07-2010
`
`Lim etal.
`
`_———
`
`
`A346
`
`2010/0304446
`
`A1
`
`12-02-2010
`
`Davies etal.
`
`_—————
`
`
`A349
`
`2010/0330619
`
`A1
`
`12-30-2010
`
`Willis etal.
`
`_———
`
`A351
`2011/0015084
`A1
`01-20-2011
`Christian etal.
`A352
`2011/0027394
`A1
`02-03-2011
`McClements etal.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
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`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`_—
`_—
`Attorney Docket Number
`94868-916163 (107220US)
`
`
`
`_—————
`_———
`_———
`_——-——
`
`
`Colston, Jr. etal.
`04-21-2011
`A1
`2011/0092373
`A358
`_———
`
`
`A361
`
`2011/0105353
`
`A1
`
`05-05-2011
`
`Loetal.
`
`_———
`
`
`A364
`
`2011/0160078
`
`A1
`
`06-30-2011
`
`Fodoretal.
`
`_———
`
`
`A367
`
`2011/0212516
`
`A1
`
`09-01-2011
`
`Nessetal.
`
`_———
`
`
`A370
`
`2011/0218123
`
`A1
`
`09-08-2011
`
`Weitzetal.
`
`_———
`
`
`Colston, Jr. etal.
`01-26-2012
`A1
`2012/0021423
`A373
`_———
`
`
`A376
`
`2012/0152369
`
`A1
`
`06-21-2012
`
`Hiddessen etal.
`
`_———
`
`
`A379
`
`2012/0190033
`
`A1
`
`07-26-2012
`
`Ness etal.
`
`_———
`
`
`A382
`
`2012/0219947
`
`A1
`
`08-30-2012
`
`Yurkovetsk etal.
`
`_———
`
`
`A385
`
`2012/0264646
`
`A1
`
`10-18-2012
`
`Linketal.
`
`_———
`
`
`A388
`
`2012/0322058
`
`A1
`
`12-20-2012
`
`Reoan etal.
`
`_———
`
`
`A391
`
`2013/0040841
`
`A1
`
`02-14-2013
`
`Saxonovetal.
`
`_———
`
`
`A394
`
`2013/0064776
`
`A1
`
`03-14-2013
`
`EIHarraketal.
`
`_———
`
`
`A397
`
`2013/0109575
`
`A1
`
`05-02-2013
`
`Kleinschmidtetal.
`
`_———
`
`A399 US 2014/0155295
`A1
`06-05-2014
`Hindson et al.
`A400 US 2014/0287963
`A1
`09-25-2014
`Hindson et al.
`
`66582559V.1
`
`
`
`Doc code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
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`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Application Number
`
`14/493,264
`
`Filing Date
`
`September 22, 2014
`
`First Named Inventor
`
`Hindson, Benjamin
`
`Art Unit
`
`Examiner Name
`
`Attorney Docket Number
`
`94868-916163 (107220US)
`
`FOREIGN PATENT DOCUMENTS
`
`Examiner
`
`Foreign Document
`Number3
`
`Cou ntry
`Code2
`
`Kind
`Code4
`
`Publication Date
`
`Name of Patentee or
`Applicant of cited
`Document
`
`—I
`
`Pages, Columns,
`Lines where
`Relevant Passages
`or Relevant Figures
`Appear
`
`Medical Research
`Council
`Todd et al.
`Landeren et al.
`Landeren
`Landeren
`Willis et al.
`Landeren
`FMC Cora.
`Shaw Stewart
`Mi azaki Pref Gov
`Weaver
`Shaw Stewart
`Gineras et al.
`Gineras et al.
`Uhlen
`
`A2
`B1
`B1
`B1
`B1
`B1
`B1
`B1
`
`04-13-2005
`04-07-2007
`12-31-2008
`1 1-08—2000
`03-05-2003
`02-20-2002
`12-12-2007
`06-10-2009
`03-08-1978
`1 1-10-1982
`04-06-1990
`08—05-1982
`05-24-1984
`12-29-1988
`06-28-1990
`02-06-1992
`
`03-17-1994
`
`04-23-1998
`
`The Regents of the
`University of
`California
`Holmbom
`04-25-1996
`
`97/09069
`Eo
`03-13-1997
`Landegren
`97/41254
`1 1 -06-1997
`Landeren
`01-08—1998
`Parce et al.
`Central Research
`Laboratories Ltd.
`Glaxo Grouo Limited
`10-08—1998
`
`98/441 52
`10-08—1998
`Glaxo Group Limited
`98/47003
`10-22-1998
`C tonix Cora.
`09-30-1999
`Landeren
`01/07159 Genset et al. 02-01-2001
`
`
`02-22-2001
`01/12327
`Ut-Bat-Telle, LLC
`10-1 8-2001
`01/77383 Nilsson et al.
`Q)N
`12-05-2002
`
`
`
`
`
` California Institute of
`
`E000000000000
`
`
`
`02/023163
`
`02/057491
`
`66582559V.1
`
`03-21-2002
`
`07-25-2002
`10-09-2003
`08—08—2002
`
`Technolo
`
`Willis etal.
`
`Genset et al.
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
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`Approved for use through 07/31/2012. OMB 0651-0031
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`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`A432
`
`02/068104
`
`wo
`
`09-06-2002
`
`Japanese Science
`and Technology
`Cor-oration
`
`
`02/081490
`wo
`10-17-2002
`E19533 B'osc'ences'
`02/081729
`WO
`10-17-2002
`California Institute of
`Technolo
`02-13-2003
`Landegren et al.
`11_13_2003
`03/012119
`
`03/016558
`wo
`02-27-2003
`Et‘t’jrbe“ Reseamh Pty'
`05-01-2003
`A2
`A3
`1 1_03_2003
`
`A435
`
`A2
`
`03/035671
`
`wo
`
`Puskas
`
`A438
`
`03/042410
`
`05-22-2003
`
`samsung E'eCtron'CS
`Co., Ltd.
`
`
`03/072258
`09-04-2003
`CarteSIa“
`Technologies, Inc.
`California Institute of
`Technolo
`
`2004/040001
`
`05-13-2004
`
`A441
`
`A442
`
`2004/044225
`
`2004/096825
`
`A443
`
`2005/007812
`
`05-27-2004
`04-06-2006
`11- 11 2—004
`
`01-27-2005
`
`Huang et al.
`Millar etal.
`
`University of Medicine
`and Dentistry of New
`Jerse et al.
`
`A444
`
`2005/010145
`
`02—03-2005
`
`
`
`
`
`The Johns Hopkins
`Universit
`President and Fellows
`2005/021 151 03-10-2005
`of Harvard College
`The Trustees of
`2005/023091
`Boston University et
`03-17-2005
`
`al.
`2005/038051
`Berlin et al.
`04-28-2005
`Beatrice and Samuel
`A448 2005/055807
`A. Seaver Foundation
`06-23-2005
`08- 11 -2005
`454 Cor.
`2005/073410
`2005/075683
`08- 18-2005
`Postech Foundation
`11 -24-2005
`.
`
`
`A452
`2006/023719
`03-02-2006
`EN'TI Researc“
`Institute
`A453
`2006/027757
`03-16-2006
`Institut Curie et al.
`
`
`2006/038035
`04-13-2006
`Med'ca' Reseamh
`Counc1l et al.
`Memorial Sloan
`2006/086777
`08-17-2006
`Kettering Cancer
`
`Center
`See-Gene, Inc.
`09-14-2006
`.
`04-19-2007
`
`11-15-2007
`Held et al.
`A457
`2007/044091
`
`2006/095981
`
`66582559V.1
`
` A449
`-II-I-II-I-I-fl
`
`
`
`
`A450
`
`A451
`
`2005/111242 W-:A 01262006
`
`MaceVIcz
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
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`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`A458
`A459
`A460
`
`2007/087312
`2007/091228
`2007/091230
`
`2007/092473
`
`0OOO
`
`08-02-2007
`08-16-2007
`08-16-2007
`
`N
`
`08-16-2007
`
`
`
`
`
`
`
`Brenner et al.
`Stokes Bio Ltd.
`Stokes Bio Ltd.
`The Board of
`Trustees of the
`Leland Stanford
`Junior Univ.
`A462 > 2007/100243 WO
`09-07-2007
`Van Eijk et al.
`A463
`2007/133710
`WO
`
`Rain'Danc9
`Technolo ies, Inc.
`
`Kapur et al.
`
`11-22-2007
`12-21-2007
`04-03-2008
`12-21-2007
`WO2007/147079 Shoemaker et al.
`03-20-2008
`President and Fellows
`of Harvard Collee
`Genizon Biosciences,
`Inc.
`Rain-Dance
`05-29-2008
`WO
`2008/063227
`
`Technologies, Inc.
`05-29-2008
`Link et al.
`WO
`2008/063227
`1 1-16-2008
`
`06-12-2008
`PGX-Health LLC
`2008/070074
`2008/070862
`06-12-2008
`Bioceot, Inc.
`President and Fellows
`2008/1091 76
`
`of Harvard College
`09-12-2008
`California Institute of
`09-12-2008
`Technolo
`Genizon Biosciences,
`Inc.
`
`
`
`
`
`
`
`
`
`
`A464
`
`200 7/ 1 470 76
`
`WO
`
`2008/021123
`
`A467
`
`2008/0241 14
`
`2008/109878
`
`A474
`
`2008/112177
`
`WO
`
`WO
`
`EEO0
`
`W
`
`0
`
`2009/014848
`
`A477
`
`A478
`
`2009/015863
`
`2009/033178
`
`EOOOO
`
`W
`
`coNcoNcoNA
`
`02-21-2008
`
`02-28-2008
`
`09-18-2008
`
`01-29-2009
`12-30-2009
`
`Advanced Liquid
`12-31-2008
`2009/002920
`
`Logic, Inc.
`True et al.
`
`02-05-2009
`
`03-12-2009
`
`F. Hoff-Man-La Roche
`AG
`Ramakrishnan
`
`A1
`
`A479
`
`2009/049889
`
`WO
`
`Roche Diagnostics
`GmbH
`04-23-2009
`University of
`E02009/085246 07-09-2009
`Massachusetts
`
`
`
`
`
`A482
`A483
`A484
`
`2010/001419
`2010/009365
`2010/018465
`2010/036352
`
`A1
`
`A1
`
`01072010
`01-21-2010
`02-18-2010
`04-01-2010
`
`Efigode Genetics
`Link et al.
`Stokes Bio Ltd.
`Colston et al.
`
`01'06'201 1
`201 1/000604
`A485
`Oberle et al.
`02232012
`Akonni Bios stems
`03-24-2011
`2011/034621
`A486
`
`A487
`2011/034631
`03-24-2011
`Ehrich et al.
`WO
`A1
`
`A2
`A3
`
`OOO
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`A488
`
`A489
`
`2011/066476
`
`201 1/079176
`
`wo
`
`06-03-2011
`
`Hindson et al. —-
`
`06-30-201 1
`
`Rain'Danc9
`Techno|01es, Inc.
`———-
`
`_
`
`Examiner
`Initials*
`
`NON-PATENT LITERATURE DOCUMENTS
`
`Include name of the author (in CAPITAL LETTERS), title of the article (when
`appropriate), title of the item (book, magazine, journal, serial, symposium, catalog,
`etc.), date, page(s), volume-issue number(s), publisher, city and/or country where
`published.
`
`European search report dated 05/08/2013 for EP Application No. 108339912.
`
`T5
`
`
`
`International preliminary Report on patentability chpt 1. PCT/NL2007/000055
`(W02007-100243) published on Sept 02, 2008.
`
`International preliminary Report on patentability chpt 1. PCT/US2007/001796
`(W02007-087312) published on July 29, 2008.
`
`International preliminary Report on patentability chpt 1. PCT/US2010/058124
`(W02011-066476) published on May 30, 2012.
`
`International search report and written opinion dated 04/07/2011 for
`PCT/U82010/058124.
`
`International search report and written opinion dated 08/03/2012 for
`PCT/U82012/024573.
`
`
`International search report and written opinion dated 08/03/2012 for
`PCT/U82012/025760.
`
`3M SPECIALTY MATERIALS, "3M Fluorinert Electronic Liquid FC-3283," product
`information guide, issued August 2001
`
`GOLDSCHMIDT GMBH, "Abil® EM 90 Emulsifier for the formulation of cosmetic
`W/0 creams fl lotions," degussa. creating essentials brochure, pgs.1-7, May
`2003
`
`66582559V.1
`
`
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`——
`Attorney Docket Number
`94868-916163 (107220US)
`
`LABSMITH, "CapTiteTM Microfluidic Interconnects" webpage, downloadedJuly 11,
`2012
`
`A503
`
`LABSMITH, "Microfluid Components" webpage, downloaded July 11, 2012
`
`
`
`A504 Polydimethylsiloxane, 5 pgs., published in FNP 52 (1992)
`
`A505
`
`THINXXS MICROTECHNOLOGY AG, "Emerald Biosystems:
`ProteinCrystallization," 1 pg., downloaded March 8, 2011
`
`ANNA et al., "Formation of dispersions using "flow focusing" in microchannels,"
`Applied Physics Letters, Vol. 82, No.3, January 20, 2003
`
`ABATE et al., "Functionalized glass coating for PDMS microfluidic devices," Lab on
`a Chip Technology: Fabrication and Microfluidics, 11 pgs., (2009)
`
`
`
`
`
`ABDELGAWAD et al., "All-terrain droplet actuation," Lab on aChip, Vol. 8, pgs.
`672-677, April2, 2008
`
`AITMAN, et al. Copy number polymorphism in chr3 predisposes to
`glomerulonephritis in rats and humans. Nature. 2006 Feb 16;439(7078):851-5.
`
`ALEXANDRIDIS, P., "Structural Polymorphism of Poly(ethylene oxide)-
`Poly(propylene oxide) Block Copolymers in Nonaqueous Polar Solvents,
`Macromolecules, Vol. 31, No. 20, pgs. 6935-6942, September 12,1998
`
`ALKAN, et al. Personalized copy number and segmental duplication maps using
`next-generation sequencing. Nat Genet. 2009 Oct;41(10):1061-7. Epub 2009 Aug
`30.
`
`
`AVILlON et al., "Human Telomerase RNA and Telomerase Activity in Immortal Cell
`Lines and Tumor Tissues," Cancer Research 56, pgs. 645-650, February 1, 1996
`
`BALIKOVA. Autosomal-dominant microtia linked to five tandem copies of a copy-
`number-variable region at chromosome 4p16. Am J Hum Genet. 2008
`Jan;82(1):181-7.
`
`BAROUD et al., "Thermocapillary valve for droplet production and sorting," Physical
`Review E 75, 046302, pgs. 046302-1-046302-5, April5,2007
`
`BARRINGER, et al. Blunt-end and single-strand ligations by Escherichia coli
`ligase:
`influence on an in vitro amplification scheme. Gene. 1990 Aug;37(4):565-
`76.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
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`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
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`Filing Date
`September 22, 2014
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`First Named Inventor
`Hindson, Benjamin
`——
`
`Attorney Docket Number
`
`94868-916163 (107220US)
`
`BEER et al., "Monodisperse droplet generation and rapid trapping for single
`molecule detection and reaction kinetics measurement," Lab on a Chip, Vol. 9, pgs.
`841-844, December 5, 2008
`
`BEER et al., "On-Chip Single-Copy Real-Time Reverse- Transcription PCR in
`Isolated Picoliter Droplets," Analytical Chemistry, Vol.80, No.6, pgs. 1854-1858,
`March 15, 2008
`
`BEER et al., "On-Chip, Real-Time, Single-Copy Polymerase Chain Reaction in
`Picoliter Droplets," Analytical Chemistry, Vol. 79, No. 22, pgs. 8471-8475,
`November 15, 2007
`
`BENNETZEN, et al. Active maize genes are unmodified and flanked by diverse
`classes or modified, highly repetitive DNA. Genome. 1994 Aug;37(4):565-76.
`
`BHAT et al., "Effect of sustained elevated temperature prior to amplification on
`template copy number estimation using digital polymerase chain reaction," Analyst,
`Vol. 136, pgs. 724-732, (2011)
`
`BHAT, et al. Single molecule detection in nanofluidic digital array enables accurate
`measurement of DNA copy number. Anal Bioanal Chem. 2009 May;394(2):457-67.
`
`
`
`
`
`Isolation of fetal DNA from nucleated erythrocytes in maternal
`BIANCHI, et al.
`blood. Proc Natl Acad Sci U S A. 1990 May;87(9):3279-83.
`
`BLOW, N., "PCR‘s next frontier," Nature Methods, Vol. 4, No. 10, pgs.869-875,
`October 2007
`
`BOETTGER, et al. Structural haplotypes and recent evolution of the human
`17q21.31 region. Nat Genet. 2012 Jul 1;44(8):881-5. doi: 10.1038/ng.2334.
`
`BOORSMAN, et al. Comparison of multiplex ligation-dependent probe
`amplification and karyotyping in prenatal diagnosis. Obstet Gynecol. 2010
`Feb;115(2 Pt 1):297-303.
`
`BRANSKY et al., "A microfluidic droplet generator based on a piezoelectric
`actuator," Lab on a Chip, Vol. 9, pgs. 516-520,November 20, 2008
`
`BRENNER et al., Gene expression analysis by massively parallel signature
`sequencing (MPSS) on microbead arrays. Nat. Biotechnol. 2000 Jun; 18(6)630-4.
`
`BROUZES, et al. Droplet microfluidic technology for single-cell high-throughput
`screening. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14195-200.
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
`
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`Approved for use through 07/31/2012. OMB 0651-0031
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`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
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`Application Number
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`14/493,264
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`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`
`Attorney Docket Number
`
`94868-916163 (107220US)
`
`BRUCH, et al. Trophoblast-Iike cells sorted from peripheral maternal blood using
`flow cytometry: a multiparametric study involving transmission electron microscopy
`and fetal DNA amplification. Prenat Diagn. 1991 Oct;11(10):787-98.
`
`Increased HER2 gene copy number is associated with
`CAPPUZZO, et al.
`response to gefitinib therapy in epidermal growth factor receptor-positive non-small-
`cell lung cancer patients. J Clin Oncol. 2005 Aug 1;23(22):5007-18.
`
`
`
`
`
`CARROLL et al., "Droplet-Based Microfluidics for Emulsion and Solvent
`Evaporation Synthesis of Monodisperse Mesoporous Silica Microspheres,"
`Langmuir, Vol. 24, No.3, pgs. 658-661, January 3, 2008
`
`CAUGHEY, et al. Chorionic villus sampling compared with amniocentesis and the
`difference in the rate of pregnancy loss. Obstet Gynecol. 2006 Sep;108(3 Pt
`1):612-6.
`
`CAWTHON, R.M., "Telomere measurement by quantitative PCR," Nucleic Acids
`Research, Vol. 30, No. 10, pgs. 1-6, (2002)
`
`CAWTHON, Richard M., "Telomere length measurement by a novel monochrome
`multiplex quantitative PCR method," Nucleic Acids Research, Vol. 37, No.3, pgs.
`1-7, (2009)
`
`CHABERT et al., "Droplet fusion by alternating current (AC) field
`electrocoalescence in microchannels," Electrophoresis, Vol. 26, pgs. 3706-3715,
`(2005)
`
`CHAN, et al. Hypermthylated RASSF1A in maternal plasma: A universal fetal
`DNA marker that improves the reliability of noninvasive prenatal diagnosis. Clin.
`Chem. 2006; 52(12):2211-2218.
`
`CHEN et al., "Janus Particles Templated from Double EmulsionDroplets Generated
`Using Microfluidics," Langmuir, Vol. 29, No.8, pgs. 4320-4323, March 18, 2009
`
`CHEN et al., "Using Three-Phase Flow oflmmiscible Liquids to Prevent
`Coalescence of Droplets in Microfluidic Channels: Criteria to Identify the Third
`Liquid and Validation with Protein Crystallization," Langmuir, Vol.23, No. 4, pgs.
`2255-2260, (2007)
`
`CHITTOFRATI et al., "Perfluoropolyether microemulsions," Progress inColloid &
`Polymer Science 79, pgs. 218-225, (1989)
`
`Chloroform (Phenomenex), Solvent Miscibility Table, Internet
`ArchiveWayBackMachine, 3 pgs., February 1, 2008
`
`66582559V.1
`
`
`
`DOC code: IDS
`Doc description: Information Disclosure Statement (IDS) Field
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`PTO/SB/OBa (01-10)
`Approved for use through 07/31/2012. OMB 0651-0031
`US. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number.
`
`
`Application Number
`
`14/493,264
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Not for submission under 37 CFR 1.99)
`
`Filing Date
`September 22, 2014
`_
`_
`_
`_
`First Named Inventor
`Hindson, Benjamin
`——
`
`Attorney Docket Number
`
`94868-916163 (107220US)
`
`CLARK, et al. High sensitivity mapping of methylated cytosines. Nucleic Acids
`Res. 1994 Aug 11;22(15):2990-7.
`
`CLAUSELL-TORMOS et al., "Droplet-Based Microfluidic Platforms for the
`Encapsulation and Screening of Mammalian Cells and Multicellular Organisms,"
`Chemistry & Biology, Vol. 15, pgs. 427-437, May 2008
`
`CONZE et al., Analysis of genes, transcripts, and proteins via DNA ligation. Annu
`Rev Anal Chem., 2009;2:215-39. Review.
`
`COOK, et al. Copy-number variations associated with neuropsychiatric conditions.
`Nature. 2008 Oct 16;455(7215):919-23.
`
`D‘ALTON. Prenatal diagnostic procedures. Semin Perinatol. 1994 Jun;18(3):140-
`62.
`
`DAHL et al. DNA methylation analysis techniques. Biogerontology. 2003;4(4):233-
`50.
`
`
`
`
`
`DAHL, et al. Circle-to-circle amplification for precise and sensitive DNA analysis.
`Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4548—53. Epub 2004 Mar 15.
`
`D