FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 1 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`F1rst Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande Suchira
`
`Atty. Docket No. QLI330
`
`U.S. PATENTS
`
`EXAMINER
`INITIALS
`
`PATENT
`NUMBER
`
`ISSUE DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`
`
`3575220
`
`4051025
`
`4201691
`
`4283262
`
`4348111
`
`4636075
`
`4948961
`
`5055390
`
`5176203
`
`5225332
`
`5270183
`
`5314809
`
`5344930
`
`5422277
`
`5538667
`
`5585069
`
`5587128
`
`5602756
`
`5720923
`
`5736314
`
`5779977
`
`1971-04-20
`
`Davis et al.
`
`1977-09-27
`
`Ito
`
`1980-05-06
`
`Asher et al.
`
`1981-08-11
`
`Cormier et al.
`
`1982-09-07
`
`Goulas et al.
`
`1987-01-13
`
`Knollenberg
`
`1990-08-14
`
`Hillman et al.
`
`1991-10-08
`
`Weaver et al.
`
`1993-01-05
`
`Larzul
`
`1993-07-06
`
`Weaver et al.
`
`1993-12-14
`
`Corbett et al.
`
`1994-05-24
`
`Erlich et al.
`
`1994-09-06
`
`Riess et al.
`
`1995-06-06
`
`Connelly et al.
`
`1996-07-23
`
`Hill et al.
`
`1996-12-17
`
`Zanzucchi et al.
`
`1996-12-24
`
`Wilding et al.
`
`1997-02-11
`
`Atwood et al.
`
`1998-02-24
`
`Haff et al.
`
`1998-04-07
`
`Hayes et al.
`
`1998-07-14
`
`Haff et al.
`
`5827480
`
`1998-10-27
`
`Haff et al.
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 2 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`F1rst Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande Suchira
`
`Atty. Docket No. QLI33O
`
`U.S. PATENTS
`
`INITIALS
`
`NUMBER
`
`
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 3 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`F1rst Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande Suchira
`
`Atty. Docket No. QLI33O
`
`U.S. PATENTS
`
`INITIALS
`
`NUMBER
`
`
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
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`-————
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`-————
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`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 4 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`F1rst Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande Suchira
`
`Atty. Docket No. QLI33O
`
`U.S. PATENTS
`
`INITIALS
`
`NUMBER
`
`
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 5 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`F1rst Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande Suchira
`
`Atty. Docket No. QLI33O
`
`U.S. PATENTS
`
`INITIALS
`
`NUMBER
`
`
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 6 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`F1rst Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande Suchira
`
`Atty. Docket No. QLI330
`
`U.S. PATENTS
`
`
`
`INITIALS
`
`NUMBER
`
`-———
`-———
`-———
`-———
`-———
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`20020195586
`2002-12-26
`Auslander et a1.
`
`20030001121
`
`2003-01-02
`
`Hochstein
`
`20030003054
`
`2003-01-02
`
`McDonald et a1.
`
`20030003441
`
`2003-01-02
`
`Colston et a1.
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 7 OF 33
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-_— Enzelberger et a1.
`
`
`
`-————
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`-————
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`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 8 OF 33
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 9 OF 33
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
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`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 10 OF
`
`3
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
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`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 11 OF
`
`3
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
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`-————
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`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 12 OF
`
`3
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
`-————
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`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 13 OF
`
`3
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-————
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`-————
`-————
`-————
`-————
`-————
`-————
`-————
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 14 OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`F1rst Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande Suchira
`
`Atty. Docket No. QLI33O
`
`U.S. PATENT APPLICATION PUBLICATIONS
`
`EXAMINER
`INITIALS
`
`PUBLICATION
`NUMBER
`
`PUBLICATION DATE
`
`NAME
`
`RELEVANT PORTION(S)
`
`-———
`-———
`-———
`-———
`
`
`
`INITIALS
`
`NUMBER
`
`CODE
`
`PORTION(S)
`
`-—-——--
`-—-——--
`
`0295433
`
`IP
`
`1990-04-06
`
`Miyazaki Pref
`Gov
`
`English
`Abstract
`
`94/05414
`
`WO
`
`1994-03-17
`
`The Regents of
`the University of
`California
`
`-
`
`98/00231
`
`98/16313
`
`WO
`
`-
`-
`19980108
`1998-04-23
`
`Central Research
`Laboratories Ltd.
`
`--
`
`98/44151
`
`WO
`
`1998-10-08
`
`Glaxo Group
`Limited
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`
`SHEET 1_5 OF
`
`3
`
`First Named Inventor: Kevin D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`98/44152
`
`WO
`
`1998-10-08
`
`Glaxo Group
`Limited
`
`
`
`English
`Abstract
`
`01/12327
`
`WO
`
`2001-02-22
`
`02/23163
`
`WO
`
`2002-03-21
`
`02/068104
`
`WO
`
`2002-09-06
`
`02/081490
`
`WO
`
`2002-10-17
`
`02/081729
`
`WO
`
`2002-10-17
`
`Ut-Bat-Telle,
`LLC
`
`California
`Institute of
`
`Technology
`
`Japanese Science
`and Technology
`Corporation
`
`Egea
`Biosciences, Inc.
`
`California
`Institute of
`
`Technology
`
`03/016558
`
`WO
`
`2003-02-27
`
`Corbett Research
`
`03/042410
`
`WO
`
`2003-05-22
`
`Pty. Ltd.
`
`Samsung
`Electronics Co.,
`Ltd.
`
`- 03/07225 8
`
`2003-09-04
`
`Cartesian
`
`Technologies,
`Inc.
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 16 OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`2004/040001
`
`WO
`
`2004-05-13
`
`2005/007812
`
`WO
`
`2005-01-27
`
`California
`Institute of
`
`Technology
`
`University of
`Medicine and
`
`Dentistry of NeW
`Jersey et al.
`
`2005/010145
`
`2o
`
`2005-02-03
`
`The Johns
`
`2005/021151
`
`2o
`
`2005-03-10
`
`2005/023091
`
`2o
`
`2005-03-17
`
`l 522 582 A2
`
`2005-04-13
`
`2005/055 807
`
`2o
`
`2005-06-23
`
`Hopkins
`University
`
`President and
`Fellows of
`
`Harvard College
`
`The Trustees of
`Boston
`
`University et al.
`
`Medical
`Research
`Council
`
`Beatrice and
`Samuel A.
`Seaver
`Foundation
`
`2005/073410
`
`2005/075683
`
`WO
`
`WO
`
`2005-08-11
`2005-08-18
`
`454 Corp -
`Postech
`Foundation
`
`2006/023719
`
`WO
`
`2006-03-02
`
`ENH Research
`Institute
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET l_7 OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`
`
`2006/038035
`
`WO
`
`2006-04-13
`
`al.
`
`Medical
`Research
`Council et al.
`
`2006/086777
`
`WO
`
`2006-08-17
`
`Memorial Sloan
`
`1 522 582 B1
`
`EP
`
`2007-04-07
`
`2007/092473
`
`WO
`
`2007-08-16
`
`Kettering Cancer
`Center
`
`Medical
`Research
`Council
`
`The Board of
`Trustees of the
`Leland Stanford
`Junior Univ.
`
`2007/133710
`
`WO
`
`2007-11-22
`
`Rain-Dance
`
`2008/021123
`
`WO
`
`2008-02-21
`
`Technologies,
`Inc.
`
`President and
`Fellows of
`
`Harvard College
`
`2008/024114
`
`WO
`
`2008-02-28
`
`Genizon
`
`Biosciences, Inc.
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 18 OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`2008/063227
`
`WO
`
`2008-05-29
`
`Rain-Dance
`
`2008/109878
`
`WO
`
`2008-09-12
`
`2008/109176
`
`WO
`
`2008-09-12
`
`Technologies,
`Inc.
`
`LLC
`
`California
`Institute of
`
`Technology
`
`President and
`Fellows of
`
`Harvard College
`
`
`
`2008/112177
`
`WO
`
`2008-09-18
`
`Genizon
`
`2009/002920
`
`WO
`
`2008-12-31
`
`2009/015 863
`
`WO
`
`2009-02-05
`
`Biosciences, Inc.
`
`Advanced Liquid
`Logic, Inc.
`
`F. Hoff-Man-La
`Roche AG
`
`2009/049889
`
`WO
`
`2009-04-23
`
`Roche
`
`2009/085246
`
`WO
`
`2009-07-09
`
`2010/001419
`
`WO
`
`2010-01-07
`
`Diagnostics
`GmbH
`
`University of
`Massachusetts
`
`Decode Genetics
`EHF
`
`-
`
`2010/018465
`
`—
`2010-02 18
`
`Stokes Bio Ltd.
`
`--
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET L OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: KeVIn D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`FOREIGN PATENT DOCUMENTS
`
`EXAMINER
`INITIALS
`
`DOCUMENT
`NUMBER
`
`COUNTRY
`CODE
`
`PUB. DATE
`
`NAME
`
`RELEVANT
`PORTION(S)
`
`T
`
`2011/034621
`
`WO
`
`2011-03-24
`
`Akonni
`
`Biosystems
`
`2011/079176
`
`WO
`
`2011-06-30
`
`Rain-Dance
`
`Technologies,
`Inc.
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`J. SMID-KORBAR et al., “Efficiency and usability of silicone surfactants in
`emulsions,” International Journal of Cosmetic Science 12, pgs. 135-139,
`(1990), presented at the 15Th IFSCC International Congress, 26-29 September,
`1988, London
`
`A. CHITTOFRATI et al., “Perfluoropolyether microemulsions,” Progress in
`Colloid & Polymer Science 79, pgs. 218-225, (1989)
`
`STEVEN A. SNOW, “Synthesis and Characterization of ZWitterionic Silicone
`Sulfobetaine Surfactants,” Langmuir, Vol. 6, No. 2, American Chemical
`Society, pgs. 385-391, (1990)
`
`Polydimethylsiloxane, 5 pgs., published in FNP 52 (1992)
`
`RUSSELL HIGUCHI et al., “Kinetic PCR Analysis: Real-time Monitoring of
`DNA Amplification Reactions,” Bio/Technology Vol. II, pgs. 1026-1030,
`September 11, 1993
`
`D. A. NEWMAN et al., “Phase Behavior of Fluoroether—Functional
`
`Amphiphiles in Supercritical Carbon Dioxide,” The Journal of Supercritical
`Fluids, Vol. 6, No. 4, pgs. 205-210, (1993)
`
`Y. SELA et al., “Newly designed polysiloxane-graft-poly (oxyethylene)
`copolymeric surfactants: preparation, surface actiVity and emulsif1cation
`properties,” Colloid & Polymer Science 272, pgs. 684-691, (1994)
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 20 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI33O
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`M. GASPERLIN et al., “The structure elucidation of semisolid W/o emulsion
`
`systems containing silicone surfactant,” International Journal of Pharmaceutics
`107, pgs. 51-56, (1994)
`
`MIECZYSLAW A. PIATYSZEK et al., “Detection of telomerase activity in
`human cells and tumors by a telomeric repeat amplification protocol (TRAP),”
`Methods in Cell Science 17, pgs. 1-15, (1995)
`
`ANTHONY P. SHUBER et al., “A Simplified Procedure for Developing
`Multiplex PCRs,” Genome Research, published by Cold Spring Harbor
`Laboratory Press, pgs. 488-493, (1995)
`
`A. V. YAZDI et al., “Highly Carbon Dioxide Soluble Surfactants, Dispersants
`and Chelating Agents,” Fluid Phase Equilibria, Vol. 117, pgs. 297-303, (1996)
`
`ARIEL A. AVILION et al., “Human Telomerase RNA and Telomerase Activity
`in Immortal Cell Lines and Tumor Tissues,” Cancer Research 56, pgs. 645-650,
`February 1, 1996
`
`SHUMING NIE et al., “Optical Detection of Single Molecules,” Annu. Rev.
`Biophys. BiomoL Struct. Vol. 26, pages 567-596, (1997)
`
`EDITH J. SINGLEY et al., “Phase behavior and emulsion formation of novel
`
`fluoroether amphiphiles in carbon dioxide,” Fluid Phase Equilibria 128, pgs.
`199-219, (1997)
`
`OLGA KALININA et al., “Nanoliter scale PCR With TaqMan Detection,”
`Nucleic Acids Research, Vol. 25, No. 10 pgs. 1999-2004, (1997)
`
`ZHEN GUO et al., “Enhanced discrimination of single nucleotide
`polymorphisms by artificial mismatch hybridization,” Nature Biotechnology
`Vol. 15, pgs. 331-335, April 1997
`
`E. G. GHENCIU et al., “Affinity Extraction into Carbon Dioxide. 1. Extraction
`of Avidin Using a Biotin-Functional Fluoroether Surfactant,” Ind. Eng. Chem.
`Res. Vol. 36, No. 12, pgs. 5366-5370, December 1, 1997
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 21 OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`PASCHALIS ALEXANDRIDIS, “Structural Polymorphism of Poly(ethylene
`oxide)-Poly(propylene oxide) Block Copolymers in Nonaqueous Polar
`Solvents, Macromolecules, Vol. 31, No. 20, pgs. 6935-6942, September 12,
`1998
`
`SANDRO R. P. DA ROCHA et al., “Effect of Surfactants on the Interfacial
`Tension and Emulsion Formation between Water and Carbon Dioxide,”
`
`Langmuir, Vol. 15, No. 2, pgs. 419-428, (1999), published on web
`December 29, 1998
`
`BERT VOGELSTEIN et al., “Digital PCR,” Proc. Natl. Acad. Sci. USA, Vol.
`96, pgs. 9236-9241, August 1999
`
`ANTHONY J. O’LENICK, JR., “Silicone Emulsions and Surfactants,” Journal
`
`of Surfactants and Detergents, Vol. 3, No. 3, July 2000
`
`N. GARTI et al., “Water Solubilization in Nonionic Microemulsions Stabilized
`
`by Grafted Siliconic Emulsifiers,” Journal of Colloid and Interface Science Vol.
`233, pgs. 286-294, (2001)
`
`SHINJI KATSURA et al., “Indirect micromanipulation of single molecules in
`water-in-oil emulsion,” Electrophoresis, Vol. 22, pgs. 289-293, (2001)
`
`HIRONOBU KUNIEDA et al., “Effect of Hydrophilic- and Hydrophobic-Chain
`Lengths on the Phase Behavior of A-B-type Silicone Surfactants in Water,” J.
`Phys. Chem. B, Vol. 105, No. 23, pgs. 5419-5426, (2001)
`
`HIDENORI NAGAI et al., “Development of A Microchamber Array for
`Picoliter PCR,” Analytical Chemistry, Vol. 73, No. 5, pgs. 1043-1047, March 1,
`2001
`
`CHRISTOPHER B. PRICE, “Regular Review Point of Care Testing,” BMJ,
`Vol. 322, May 26, 2001
`
`3M SPECIALTY MATERIALS, “3M Fluorinert Electronic Liquid FC-3283,”
`product information guide, issued August 2001
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 22 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`IVONNE SCHNEEGAB et al., “Miniaturized flow-through PCR With different
`template types in a silicon chip thermocycler,” Lab on a Chip, Vol. 1, pgs. 42-
`49, (2001)
`
`RANDLA M. HILL, “Silicone surfactants — new developments,” Current
`Opinion in Colloid & Interface Science 7, pgs. 255-261, (2002)
`
`RICHARD M. CAWTHON, “Telomere measurement by quantitative PCR,”
`Nucleic Acids Research, Vol. 30, No. 10, pgs. 1-6, (2002)
`
`ANFENG WANG et al., “Direct Force Measurement of Silicone- and
`
`Hydrocarbon-Based ABA Triblock Surfactants in Alcoholic Media by Atomic
`Force Mircroscopy,” Journal of Colloid and Interface Science 256, pgs. 331-
`340 (2002)
`
`SHELLEY L. ANNA et al., “Formation of dispersions using “flow focusing” in
`microchannels,” Applied Physics Letters, Vol. 82, No. 3, January 20, 2003
`
`GOLDSCHMIDT GMBH, “Abil® EM 90 Emulsif1er for the formulation of
`
`cosmetic W/O creams m lotions,” degussa. creating essentials brochure, pgs.
`1-7, May 2003
`
`PURNENDU K. DASGUPTA et al., “Light emitting diode-based detectors
`Absorbance, fluorescence and spectroelectrochemical measurements in a planar
`flow-through cell,” Analytica Chimica Acta 500, pgs. 337-364, (2003)
`
`R. G. RUTLEDGE et al., “Mathematics of quantitative kinetic PCR and the
`application of standard curves,” Nucleic Acids Research, Vol. 31, No. 16, pgs.
`1-6, (2003)
`
`CHUNMING DING et al., “Direct molecular haplotyping of long-range
`genomic DNA with Ml-PCR,” PNAS, Vol. 100, No. 13, pgs. 7449-7453, June
`24, 2003
`
`DEVIN DRESSMAN et al., “Transforming single DNA molecules into
`fluorescent magnetic particles for detection and enumeration of genetic
`variations,” PNAS, Vol. 100, No. 15, July 22, 2003
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 23 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`ULF LANDEGREN et al., “Padlock and proximity probes for in situ and array-
`based analyses: tools for the post-genomic era,” Comp. Funct. Genom, Vol. 4,
`pgs. 525-530, (2003)
`
`GUDRUN POHL et al., “Principle and applications of digital PCR” review,
`WWW.future-drugs.com, Expert Rev. Mol. Diagn. 4(1), pgs. 41-47, (2004)
`
`GROFF M. SCHROEDER et al., “Introduction to Flow Cytometry” version 5.1,
`182 pgs. (2004)
`
`STEPHANE SWILLENS et al., “Instant evaluation of the absolute initial
`number of cDNA copies from a single real-time PCR curve,” Nucleic Acids
`Research, Vol. 32, No. 6, pgs. 1-6, (2004)
`
`MATS GULLBERG et al., “Cytokine detection by antibody-based proximity
`ligation,” PNAS, Vol. 101, No. 22, pgs. 8420-8424, June 1, 2004
`
`TIANHAO ZHANG et al., “Behavioral Modeling and Performance Evaluation
`of Microelectrofluidics-Based PCR Systems Using SystemC,” IEEE
`Transactions on Computer-Aided Design of Integrated Circuits and Systems,
`Vol. 23, No. 6, pgs. 843-858, June 2004
`
`R. G. RUTLEDGE, “Sigmoidal curve-fitting redefines quantitative real-time
`PCR With the prospective of developing automated high-throughput
`applications,” Nucleic Acids Research. Vol. 32, No. 22, pgs. 1-8, (2004)
`
`L. SPENCER ROACH et al., “Controlling Nonspecific Protein Absorption in a
`Plug-Based Microfluidic System by Controlling Interfacial Chemistry Using
`Fluorous-Phase Surfactants,” Analytical Chemistry Vol. 77, No. 3, pgs. 785-
`796, February 1, 2005
`
`KEVIN D. DORFMAN et al., “Contamination-Free Continuous Flow
`
`Microfluidic Polymerase Chain Reaction for Quantitative and Clinical
`Applications,” Analytical Chemistry Vol. 77, No. 11, pgs. 3700-3704, June 1,
`2005
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET A OF A
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`JAMES G. WETMUR et al., “Molecular haplotyping by linking emulsion PCR:
`analysis of paraoxonase 1 haplotypes and phenotypes,” Nucleic Acids
`Research, Vol. 33, No. 8, pgs. 2615-2619, (2005)
`
`PIOTR GARSTECKI et al., “Mechanism for Flow-Rate Controlled Breakup in
`Conflned Geometries: A Route to Monodisperse Emulsions,” Physical Review
`Letters, 164501, pgs. 164501-1 — 164501-4, April 29, 2005
`
`ANNA MUSYANOVYCH et al., “Miniemulsion Droplets as Single Molecule
`Nanoreactors for Polymerase Chain Reaction,” Biomacromolecules, Vol. 6, No.
`4, pgs. 1824-1828, (2005)
`
`MAX CHABERT et al., “Droplet fusion by alternating current (AC) field
`electrocoalescence in microchannels,” Electrophoresis, Vol. 26, pgs. 3706-
`3715 , (2005)
`
`TAKAAKI KOJIMA et al., “PCR amplification from single DNA molecules on
`magnetic beads in emulsion: application for high-throughput screening of
`transcription factor targets,” Nucleic Acids Research, Vol. 33, No. 17, pgs. 1-9,
`(2005)
`
`MARCEL MARGULIES et al., “Genome sequencing in microfabricated high-
`density picolitre reactors,” NATURE, Vol. 437, 51 pgs., September 15, 2005
`
`KRISTOFER J. THURECHT et al., “Investigation of spontaneous
`microemulsion formation in supercritical carbon dioxide using high-pressure
`NMR,” Journal of Supercritical Fluids, Vol. 38, pgs. 111-118, (2006)
`
`TOSHKO ZHELEV et al., “Heat Integration in Micro-Fluidic Devices,” 16Th
`European Symposium on Computer Aided Process Engineering and 9Th
`International Symposium on Process Systems Engineering, pgs. 1863-1868
`published by Elsevier B.V. (2006)
`
`PIOTR GARSTECKI et al., “Formation of droplets and bubbles in a
`microfluidic T-junction — scaling and mechanism of break-up,” Lab on a Chip,
`Vol. 6, pgs. 437-446, (2006)
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 25 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`First Named Inventor: Kev1n D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`T
`
`
`
`DARREN R. LINK et al., “Electric Control of Droplets in Microfluidic
`Devices,” Angewandte Chemie Int. Ed., Vol. 45, pgs. 2556-2560, (2006)
`
`PETER FIELDEN et al., “Micro-Droplet Technology for High Throughout
`Systems and Methods,” 1 pg., March 8, 2006
`
`DAVID EMERSON et al., “Microfluidic Modelling Activities at C3M,” Centre
`for Microfluidics & Microsystems Modelling, Daresbury Laboratory, pgs. 1-26,
`May 15, 2006
`
`RICHARD WILLIAMS et al., “Amplification of complex gene libraries by
`emulsion PCR,” Nature Methods, Vol. 3, No. 7, pgs. 545-550, July 2006
`
`JOHN H. LEAMON et al., “Overview: methods and applications for droplet
`compartmentalization of biology,” Nature Methods, Vol. 3, No. 7, pgs. 541-
`543, July 2006
`
`ANDREW D. GRIFFITHS et al., “Miniaturising the laboratory in emulsion
`droplets,” TRENDS in Biotechnology, Vol. 24, No. 9, pgs. 395-402, July 14,
`2006
`
`JIAN-BING FAN et al., “Highly parallel genomic assays,” Nature
`Reviews/Genetics, Vol. 7, pgs. 632-644, August 2006
`
`JONAS JARVIUS et al., “Digital quantification using amplified single-
`molecule detection,” Nature Methods, Vol. 3, No. 9, pgs. 15 pgs, September
`2006
`
`KAN LIU et al., “Droplet-based synthetic method using microflow focusing
`and droplet fusion,” Microfluid Nanfluid, Vol. 3, pgs. 239-243, (2007),
`published online September 22, 2006
`
`DIMITRIS GLOTSOS et al., “Robust Estimation of Bioaffmity Assay
`Fluorescence Signals,” IEEE Transactions on Information Technology in
`Biomedicine, Vol. 10, No. 4, pgs. 733-739, October 2006
`
`KRISTOFER J. THURECHT et al., “Kinetics of Enzymatic Ring-Opening
`Polymerization of E-Caprolactone in Supercritical Carbon Dioxide,”
`Macromolecules, Vol. 39, pgs. 7967-7972, (2006)
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 26 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`MACHIKO HORI et al., “Uniform amplification of multiple DNAs by
`emulsion PCR,” Biochemical and Biophysical Research Communications, Vol.
`352, pgs. 323-328, (2007)
`
`FRANK DIEHL et al., “Digital quantification of mutant DNA in cancer
`patients,” Current Opinion in Oncology, Vol. 19, pgs. 36-42, (2007)
`
`DELAI L. CHEN et al., “Using Three-Phase Flow of Immiscible Liquids to
`Prevent Coalescence of Droplets in Microfluidic Channels: Criteria to Identify
`the Third Liquid and Validation With Protein Crystallization,” Langmuir, Vol.
`23, No. 4, pgs. 2255-2260, (2007)
`
`S. MOHR et al., “Numerical and experimental study of a droplet-based PCR
`chip,” Microfluid Nanofluid, Vol. 3, pgs. 611-621, (2007)
`
`SIGRUN M. GUSTAFSDOTTIR et al., “In vitro analysis of DNA-protein
`interactions by proximity ligation,” PNAS, Vol. 104, No. 9, pgs. 3067-3072,
`February 27, 2007
`
`DANIEL J. DIEKEMA et al., “Look before You Leap: Active Surveillance for
`Multidrug-Resistant Organisms,” Healthcare Epidemiology - CID 2007:44, pgs.
`1101-1107 (15 April), electronically published March 2, 2007
`
`CHARLES N. BAROUD et al., “Thermocapillary valve for droplet production
`and sorting,” Physical RevieW E 75, 046302, pgs. 046302-1 — 046302-5, April
`5, 2007
`
`QINYU GE et al., “Emulsion PCR-based method to detect Y chromosome
`microdeletions,” Analytical Biochemistry, Vol. 367, pgs. 173-178,
`May 10, 2007
`
`CHUNSUN ZHANG et al., “Miniaturized PCR chips for nucleic acid
`amplification and analysis: latest advances and future trends,” Nucleic Acids
`Research, Vol. 35, No. 13, pgs. 4223-4237, June 18, 2007
`
`Y. M. DENNIS LO et al., “Digital PCR for the molecular detection of fetal
`chromosomal aneuploidy,” PNAS, Vol. 104, No. 32, pgs. 13116-13121, August
`7, 2007
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 2_7 OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`DAYONG JIN et al., “Practical Time-Gated Luminescence Flow Cytometry. II:
`Experimental Evaluation Using UV LED Excitation,” Cytometry Part A - 71A,
`pgs. 797-808, August 24, 2007
`
`HELEN R. HOBBS et al., “Homogeneous Biocatalysis in both Fluorous
`Biphasic and Supercritical Carbon Dioxide Systems,” Angewandte Chemie,
`Vol. 119, pgs. 8006-8009, September 6, 2007
`
`NATHAN BLOW, “PCR’s next frontier,” Nature Methods, Vol. 4, No. 10, pgs.
`869-875, October 2007
`
`NICOLE PAMME, “continuous flow separations in microfluidic devices,” Lab
`on a Chip, Vol. 7, pgs. 1644-1659, November 2, 2007
`
`N. REGINALD BEER et al., “On-Chip, Real-Time, Single-Copy Polymerase
`Chain Reaction in Picoliter Droplets,” Analytical Chemistry, Vol. 79, No. 22,
`pgs. 8471-8475, November 15, 2007
`
`YUEJUN ZHAO et al., “Microparticle Concentration and Separation by
`Traveling-Wave Dielectrophoresis (tWDEP) for Digital Microfluidics,” Journal
`of Microelectromechanical Systems, Vol., 16, No. 6, pgs. 1472-1481, December
`2007
`
`SIGMA-ALDRICH, “Synthesis of Mesoporous Materials,” Material Matters,
`3.1, 17, (2008)
`
`NICK J. CARROLL et al., “Droplet-Based Microfluidics for Emulsion and
`Solvent Evaporation Synthesis of Monodisperse Mesoporous Silica
`Microspheres,” Langmuir, Vol. 24, No. 3, pgs. 658-661, January 3, 2008
`
`SHIA-YEN TEH et al., “Droplet microfluidics,” Lab on a Chip, Vol. 8, pgs.
`198-220, January 11, 2008
`
`Chloroform (Phenomenex), Solvent Miscibility Table, Internet Archive
`WayBackMachine, 3 pgs., February 1, 2008
`
`N. REGINALD BEER et al., “On-Chip Single-Copy Real-Time Reverse-
`Transcription PCR in Isolated Picoliter Droplets,” Analytical Chemistry, Vol.
`80, No. 6, pgs. 1854-1858, March 15, 2008
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET 28 OF 33
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`PALANI KUMARESAN et al., “High-Throughput Single Copy DNA
`Amplification and Cell Analysis in Engineered Nanoliter Droplets,” Analytical
`Chemistry, 17 pgs., April 15, 2008
`
`SOMIL C. MEHTA et a., “Mechanism of Stabilization of Silicone Oil — Water
`
`Emulsions Using Hybrid Siloxane Polymers,” Langmuir, Vol. 24, No. 9, pgs.
`4558-4563, March 26, 2008
`
`RHUTESH K. SHAH et al., “Polymers fit for function Making emulsions drop
`by drop,” Materials Today, Vol. 11, No. 4, pgs. 18-27, April 2008
`
`MOHAMED ABDELGAWAD et al., “All-terrain droplet actuation,” Lab on a
`Chip, Vol. 8, pgs. 672-677, April 2, 2008
`
`LUNG-HSIN HUNG et al., “Rapid microfabrication of solvent-resistant
`biocompatible microfluidic devices,” Lab on a Chip, Vol. 8, pgs. 983-987, April
`8, 2008
`
`JENIFER CLAUSELL-TORMOS et al., “Droplet-Based Microfluidic Platforms
`for the Encapsulation and Screening of Mammalian Cells and Multicellular
`Organisms,” Chemistry & Biology, Vol. 15, pgs. 427-437, May 2008
`
`VIVIENNE N. LUK et al., “Pluronic Additives: A Solution to Sticky Problems
`in Digital Microfluidics,” Langmuir, Vol. 24, No. 12, pgs. 6382-6289, May 16,
`2008
`
`YEN-HENG LIN et al., “Droplet Formation Utilizing Controllable Moving-
`Wall Structures for Double-Emulsion Applications,” Journal of
`Microelectromechanical Systems, Vol. 17, No. 3, pgs. 573-581, June 2008
`
`SIMANT DUBE et al., “Mathematical Analysis of Copy Number Variation in a
`DNA Sample Using Digital PCR on a Nanofluidic Device,” PLoS ONE, Vol. 3,
`Issue 8, pgs. 1-9, August 6, 2008
`
`JIAN QIN et al., “Studying copy number variations using a nanofluidic
`platform,” Nucleic Acids Research, Vol. 36, No. 18, pgs. 1-8, August 18, 2008
`
`C. HOLTZE et al., “Biocompatible surfactants for water-in-fluorocarbon
`emulsions,” Lab on a Chip, Vol. 8, pgs. 1632-1639, September 2, 2008
`
`EXAMINER
`SIGNATURE:
`
`DATE
`CONSIDERED:
`
`

`

`FORM PTO-1449
`
`Application Number: 13/287,095
`
`SHEET A OF
`
`3
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date: November 1, 2011
`.
`.
`F1rst Named Inventor: Kevm D. Ness
`
`Art Unit: 1637
`
`Examiner: Pande, Suchira
`
`Atty. Docket No. QLI330
`
`NON-PATENT LITERATURE DOCUMENTS
`
`EXAMINER
`INITIALS
`
`AUTHOR, TITLE, AND CITATION
`
`I
`
`
`
`MARGARET MACRIS KISS et al., “High-Throughput Quantitative
`Polymerase Chain Reaction in Picoliter Droplets,” Analytical Chemistry, 8 pgs.,
`downloaded November 17, 2008
`
`JAY SHENDURE et al., “Next-generation DNA sequencing,” Nature
`Biotechnology, Vol. 26, No. 10, pgs. 1135-1145, October 2008
`
`BERNHARD G. ZIMMERMANN et al., “Digital PCR: a powerful new tool for
`noninvasive prenatal diagnosis?,” Prenatal Diagnosis, Vol.

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