`Trials
`Tel: 571-272-7822
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`Paper 18
`.
`Entered: June 15, 2018, 2018
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`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`
`10X GENOIVHCS, INC.,
`
`Petitioner,
`
`V.
`
`BIO-RAD LABORATORIES, INC,
`Patent Owner.
`
`Case IPR2018-00301
`
`Patent 9,216,392 B2
`
`Before KRISTINA M. KALAN, JON B. TORNQUIST, and
`JEFFREY W. ABRAHAM, Administrative Patent Judges.
`
`TORNQUIST, Administrative Patent Judge.
`
`DECISION
`
`Denying Institution of Inter Partes Review
`35 USC. § 314(a)
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`
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`IPR2018-00301
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`Patent 9,216,392 B2
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`1.
`
`INTRODUCTION
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`10X Genomics, Inc. (“Petitioner”) filed a Petition (Paper 2, “Pet.”)
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`requesting inter partes review of claims 1—21 of US. Patent
`
`No. 9,216,392 B2 (Ex. 1001, “the ’392 patent”). Bio-Rad Laboratories, Inc.
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`(“Patent Owner”) filed a Preliminary Response to the Petition (Paper 12,
`
`“Prelim. Resp”).1
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`We have authority to determine whether to institute an inter partes
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`review. 35 U.S.C. § 314. The standard for instituting an inter partes review
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`is set forth in 35 U.S.C. § 314(a), which provides that an inter partes review
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`may not be instituted “unless the Director determines .
`
`.
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`. there is a
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`reasonable likelihood that the petitioner would prevail with respect to at
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`least 1 of the claims challenged in the petition.”
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`After considering the Petition, the Preliminary Response, and the
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`evidence of record, we determine that Petitioner has not demonstrated a
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`reasonable likelihood that it would prevail with respect to at least one claim
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`challenged in the Petition. Accordingly, we do not institute an inter partes
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`review.
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`1. Related Proceedings
`
`The parties identify Bio-Rad Laboratories, Inc. v. 10X Genomics, Inc,
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`Case No. 3:17~CV-4339 (N.D. Cal.) and Re: Certain Microfluidic Devices,
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`Investigation Number 337-TA-1068 (ITC) as related matters. Pet. 1; Paper
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`5, 1. The parties also note that the ’392 patent is at issue in IPR2018-00300
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`and IPR2018-00302. Pet. 1; Paper 7, 1.
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`1 Patent Owner identifies Lawrence Livermore National Security LLC as a
`real party in interest. Paper 5, 1.
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`
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`IPR2018-00301
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`Patent 9,216,392 B2
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`3. The ’392 Patent
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`The ’392 patent discloses a system for forming an array of emulsions
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`that consist of liquid droplets disposed in an immiscible carrier liquid.
`
`Ex. 1001, 1:46—47, 10:11—12. Figure 24, reproduced below, is a schematic
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`’ View of a “four-port” droplet generator of the ’392 patent (id. at 35:41—42):
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`Fig. 24
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`
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`In the droplet generator depicted in Figure 24, oil wells 1224 are loaded with
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`a carrier fluid (e.g., oil) and sample well 1226 is loaded with a sample (e.g.,
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`an assay mixture, such as a PCR mixture including a sample and a reagent).
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`Id. at 35:42—47. The wells are “connected fluidly by channels 1230 formed
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`near the bottom” of the well. Id. at 35:35—37. The individual channels
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`connect at intersection 1232, where droplets are formed by “any suitable
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`mechanism, such as flow—focusing.” Id. at 35:37—40. The ’392 patent
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`explains that pressure may be applied to wells 1224 and 1226, as indicated
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`by vertical arrows 1234, “to drive fluid flow, droplet generation, and flow of
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`the resulting droplets as an emulsion 1236 to emulsion well 1228.” Id. at
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`35:47—51.
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`Patent 9,216,392 B2
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`Figures 22, 23, and 25 of the ’392'patent are reproduced below:
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`PRESSURE
`SOURCE
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`1234\
`
`
`12'30
`1230
`1250 1252 123012“4 12'42
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`Figures 22 and 23 show exemplary device 1220 equipped with an array of
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`droplet generators 1222. Id. at 35:27—30. As shown in Figure 23, each
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`droplet generator 1222 may include wells, or reservoirs 1224, 1226, and
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`1228, which can be accessed from above plate 1220. Id. at 35:32—35. The
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`wells are fluidly connected by channels 1230. Id. at 35:35—40. Figure 25 is
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`a section view of plate 1220 assembled with pressure manifold 1238, which
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`is connected to one or more pressure sources (e.g., pressure sources 1248
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`and 1250) that exert pressure on the oil and sample wells to drive fluid flow.
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`Id. at 35:47—51, 35:56—59, 36:20—22, 36:36—41.
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`
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`IPR2018-00301
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`Patent 9,216,392 B2
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`C. Illustrative Claim
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`Petitioner challenges claims 1—21 of the ’392 patent. Claim 1, the
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`only independent claim in the ’392 patent, is illustrative of the challenged
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`claims and is reproduced below:
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`1. A system for forming an array of emulsions, comprising:
`
`a plate including an array of emulsion production units, each
`unit including
`
`at least one first input well to hold a continuous phase for an
`emulsion,
`
`a second input well to hold a dispersed phase for an emulsion,
`and
`
`an output well connected to the first and second input wells by
`a set of channels that form a channel junction, the set of
`channels including at least two input channels extending
`separately from the input wells to the channel junction and an
`output channel extending from the channel junction to the
`output well, each channel of the set of channels being
`, circumferentially bounded; and
`
`a vacuum or pressure source configured to be connected
`operatively to wells of the plate to form a pressure drop
`between the input wells and the output well of each unit to
`drive the continuous phase and the dispersed phase from the
`first and second input wells of the unit to the channel junction,
`at which droplets of the dispersed phase are generated, and
`through the output channel for collection in the output well of
`the unit.
`
`Ex. 1001, 162:10—32.
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`'J‘I
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`IPR2018—00301
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`Patent 9,216,392 B2
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`D. The Asserted Grounds of Unpatentability
`Petitioner contends claims 1—21 of the ’392 patent are unpatentable
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`based on the following grounds (Pet. 13, 52, 54, 57, 69):2
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`References
`
`Basis
`
`Claim 3 Challen_ed
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`Quake3, Dale“, Chien I5, and Chien H6
`
`§ 103
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`1—6, 8, 10, 11, and 21
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`Quake, Dale, Chien I, Chien II, and
`
`§ 103
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`7
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`Quake, Dale, Chien I, Chien II, and
`Modlin8
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`§ 103
`
`
`Hsieh7
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`Quake, Dale, Chien I, Chien II, and
`Soane9
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`§ 103
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`12—17, 19, and 20
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`Quake, Dale, Chien I, Chien II, and
`Beer10
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`§ 103
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`18
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`A. Claim Construction
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`II.
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`ANALYSIS
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`In an inter partes review, claim terms in an unexpired patent are
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`construed according to their broadest reaswiable interpretation in light of the
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`2 Petitioner also relies on a declaration from Dr. Khushroo Gandhi
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`(Ex. 1003).
`3 US 2002/0058332 A1, published May 16, 2002 (Ex. 1004).
`4 US 2008/0056948 A1, published Mar. 6, 2008 (Ex. 1005).
`5 US 6,915,679 B2, issued July 12, 2005 (Ex. 1006).
`6 Ring-Ling Chien and J. Wallace Parce, Multiportflow-control system for
`lab—on-a-chip microfluidic devices, Fresenius J. Anal. Chem. 371:106—1 11
`(2001) (Ex. 1035).
`7 US 2008/0166720 A1, published July 10, 2008 (Ex. 1019).
`8 US 2005/0266582 A1, published Dec. 1, 2005 (Ex. 1007).
`9 US 6,176,962 B1, issued Jan. 23, 2001 (BX. 102]).
`10 Beer et al., On-Chip, Real—Time, Single-Copy Polymerase Chain Reaction
`in Picoliter Droplets; Anal. Chem., 79, 8471—8475 (2007) (Ex. 1032).
`
`6
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`Patent 9,216,392 B2
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`specification of the patent in which they appear. 37 CPR. § 42.100(b);
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`Cuozzo Speed Techs, LLC v. Lee, 136 S. Ct. 2131, 2144—46 (2016)
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`(upholding the use of the broadest reasonable interpretation standard).
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`Upon review of the parties’ arguments and supporting evidence, we
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`determine that no claim terms of the ’3 92 patent require express construction
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`for purposes of this decision. See Nidec Motor Corp. v. Zhongshan Broad
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`Ocean Motor Co., 868 F.3d 1013, 1017 (Fed. Cir. 2017) (citing Vivid Techs,
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`Inc'. v. Am. Sci. & Eng ’g, Inc, 200 F.3d 795, 803 (Fed. Cir. 1999) (“[O]nly
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`those terms need be construed that are in controversy, and only to the extent
`
`necessary to resolve the controversy.”)).
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`B. Claims 1-6, 8, 10, 11, and 21 over Quake, Dale, Chien I, and
`Chien 1]
`
`Petitioner contends the subject matter of claims 1—6, 8, 10, 11, and 21
`
`would have been obvious over the combined disclosures of Quake, Dale,
`
`Chien I, and Chien 11. Pet. 13—5 1.
`
`1. Quake
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`Quake discloses a device and methods for analyzing and/or sorting
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`biological materials, including, proteins, enzymes, viruses, and cells.
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`Ex. 1004, Abstract. The devices and methods of Quake comprise “at least
`one analysis unit having an inlet region in communication with a main ’
`
`channel at a droplet extrusion region (e.g., for introducing droplets of sample
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`into the main channel),” a detection region, and a detector associated with
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`the detection region. Id. 11 76. As the droplets pass into the detection region,
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`they are examined by the detector for a predetermined charactcristic. Id.
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`11 78. Quake teaches that some embodiments may include multiple detection
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`regions and detectors, as well as “a discrimination region or branch point in
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`communication with the main channel and with branch channels, and a flow
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`control responsive to the detector” for sorting droplets. Id. 111] 77, 79 (noting
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`that a “plurality of analysis units of the invention may be combined in one
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`device,” and that such a multiplexed system “can be adapted to provide a
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`very high throughput”). Quake further discloses the option of using “a
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`plurality of inlet regions, each of which introduces droplets of a different
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`sample .
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`.
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`. into the main channel.” Id. 11 77.
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`Quake’s droplet extrusion regions “are designed to compartmentalize
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`small droplets of aqueous solution within microfluidic channels filled with
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`oil.” Id. fl 3. Specifically, Quake explains
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`[t]he droplet extrusion region generally comprises a junction
`- between the sample inlet and the main channel such that a
`pressurized solution of a sample (Le, a fluid containing a sample
`such as cells, Virions or molecules) is introduced to the main
`channel in droplets. Preferably, the sample inlet intersects the
`main channel such that
`the pressurized sample solution is
`introduced into the main channel at an angle perpendicular to a
`stream of fluid passing through the main channel. For example,
`in preferred embodiments,
`the sample inlet and main channel
`intercept at a T-shapedjunction; i.e., such that the sample inlet is
`perpendicular (90 degrees) to the main channel.
`
`Id. 11 84.
`
`Figure 16B of Quake, reproduced below, shows an exemplary
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`architecture for droplet extrusion regions in a microfabricated device. Id.
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`11 39.
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`Patent 9,216,392 B2
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`-~ 1603
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`/1606
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`FIG. 16B
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`1605
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`In Figure 16B, inlet channel 1603 intersects main channel 1605, forming a
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`T-shaped junction. Id. 1111 15, 299—300. As an aqueous solution is
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`pneumatically driven through channel 1603 it is sheared into droplets as it
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`enters the oil stream in main channel 1605. Id. 1111 290, 299—300. These
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`droplets then are driven through outlet channel 1604, and may subsequently
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`be routed through different channel architectures to allow individual droplets
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`to be sorted and/or analyzed. Id. 1111 16, 290, 294, 300.
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`Quake explains that, in this process of droplet generation, the required
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`fluids may be loaded into the microfabricated device via separate syringes
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`that are fitted with high-pressure connection fittings. Id. 11 288. “The
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`pressures of the different fluids are then adjusted so that their pressures are
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`balanced at the droplet extrusion region.” Id. 11 290. “Droplet extrusion can
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`then be initiated by slightly adjusting the pressure difference between the
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`different fluids” so that the droplet fluid is sheared off at a fixed frequency.
`Id. Quake explains that this frequency of droplet generation “can be readily
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`adjusted by simply adjusting the pressures of the individual fluid lines.” Id.
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`2. Dale
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`Dale discloses a vessel for performing microfluidic assays and, in
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`particular, an “assembly for performing microfluidic assays [that] includes a
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`Patent 9,216,392 B2
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`micro-fluidic chip with access ports,” microchannels that are in
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`communication with the access ports, and a fluid cartridge that is configured
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`to be coupled with one or more access ports. Ex. 1005, Abstract.
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`Figure 1b of Dale is reproduced below:
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`
`
`FlG. 1b
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`As shown in Figure 1b, cartridge 10 is coupled to micro-fluidic chip 40. Id.
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`11 28. Cartridge 10 may have internal chambers containing various fluids
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`that are coupled to access ports 44, 46, and 48 of microfluidic chip 40 via
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`nozzles 14, 16, and 18 (not numbered in Figure 1b). Id. 111] 29, 32—33.
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`Microchannels extending through microchip 40 are in communication with
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`access ports 44, 46, and 48. Id. 11 32. Cartridge 10 may include vacuum
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`port 24 connected to a source of negative pressure (i.e., vacuum), and
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`facilitates movement of reaction waste products into a waste chamber. Id.
`
`'n 29.
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`3. Chien I
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`Chien I discloses devices, systems, and methods for flexibly and
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`selectively transporting “fluids within microfluidic channels of a
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`microfluidic network by applying, controlling, and varying pressures at a
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`plurality of reservoirs or ports.” Ex. 1006, 2:56—61. Figure 1 of Chien I is
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`reproduced below:
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`10
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`25‘.
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`Fig. 1
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`As shown in Figure 1, microfluidic system 10 includes microfluidic
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`device 12 coupled to a bank of pressure modulators 14. Id. at 9:43—46.
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`Each pressure modulator is in fluid communication with reservoir 18 of
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`microfluidic device 12 via associated tube 20. Id. at 9:51—52.
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`Figure 2 of Chien I, reproduced below, shows microfluidic device 12
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`(id. at 10:35):
`
`
`
`Fig. 2
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`Microfluidic device 12 includes an array of reservoirs 18a, 18b, etc. coupled
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`together by microscale channels defining microfluidic network 30. Id.
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`at 10:36—38. Chien I explains that the micrufluidic devices of the invention
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`typically include at least one microscale channel and usually “at least two
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`intersecting microscale channel segments” disposed within a single body
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`structure. 1d. at 10:57—61.
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`11
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`4. Chien II
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`Chien 11 describes the same embodiment as Chien 1. Pet. 19. Chien H
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`notes that, although hydrodynamic flow has been used in microfluidic
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`systems, its use may have certain limitations:
`
`The use of external pumps to force liquids directly through
`microfluidic
`channels
`has
`previously
`been
`proposed.
`Incorporation of mechanical micro pumps and valves within a
`microfluidic device to move the fluids within a microfluidic
`
`channel has also been tested. Unfortunately, the flow rate in the
`microfluidic systems is usually on the order of nL s“. Accurate
`control of such a tiny flow of an incompressible liquid is
`extremely difficult. Lack of proper control of small pressure
`differences will yield irreproducible and erratic results. A system
`that controls the pressure of a compressible gas at the fluid-air
`interface directly on top of the wells of the microfluidic device is
`a more practical design.
`
`Ex. 1035, 106.
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`5. Analysis
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`Petitioner contends one of ordinary skill in the art would have found it
`
`obvious to combine the teachings of Quake, Dale, Chien I, and Chien II11 to
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`form a “Combined System” that includes every limitation of independent
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`claim 1. Pet. 14, 22, 27—42. The Combined System, as depicted by
`
`Petitioner, is reproduced below:
`
`” We refer to Chien I and Chien H collectively as “Chien.”
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`l2
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`
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`FIG. 1
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`,Id. at 22.
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`To form this Combined System, Petitioner contends an ordinary
`
`artisan would have first implemented multiple instances of Quake’s droplet
`
`generator on a single chip, such as the one disclosed in Dale, as depicted
`
`below:
`
`
`
`FIG 1613
`
`.7am»
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`Id. at 18—19 (“Quake taken in View of Dale renders obvious the provision of
`
`multiple droplet generators on a single microfluidic chip, for multiple
`
`reasons”). Once a skilled artisan chose to implement multiple copies of
`
`Quake’s droplet generator on a single chip, Petitioner contends this skilled
`
`artisan would have found it obvious to use Chien’s pneumatic manifold and
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`plate design to drive fluids through this parallelized array of droplet
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`generators. Id. at 21—22.
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`13
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`Petitioner contends one of ordinary skill in the art would have sought
`
`to combine Quake and Dale because parallelization was known to result in
`
`higher throughput, the proposed combination would enable multiplexing of
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`different reactions, and implementation of Dale’s parallelization method
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`would constitute the use of a known technique to improve a similar device in
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`the same way. Id. at 18—19. Petitioner fiirther contends that one of ordinary
`
`skill in the art would have sought to implement Chien’s multi-reservoir plate
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`and pressure control system in the Combined System because Chien’s
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`system provides increased pressure control and would allow the omission of
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`expensive fluid reservoirs and pumps. Id. at 25—26.
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`Patent Owner argues Petitioner has failed to provide a reasonable
`
`explanation as to why one of ordinary skill in the art would have sought to
`
`combine Quake, Dale, and Chien. Prelim. Resp. 28—30. Patent Owner
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`asserts Petitioner does not explain why a person of ordinary skill in the art
`
`would have taken “just a portion” of Quake’s device and then attempted “to
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`replicate solely that portion in parallel in the single-layered chips of Dale,”
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`or why Chien would have motivated one of ordinary skill in the art to
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`modify Quake to incorporate its fluid drive technique. Id. at 28—29.
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`Upon review of the parties’ arguments and supporting evidence, as
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`well as Dr. Gandhi’s declaration testimony, we determine that Petitioner has
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`not sufficiently demonstrated that one of ordinary skill in the art would have
`
`combined Quake, Dale, and Chien to arrive at the subject matter of the
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`challenged claims.
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`a. The Proposed Combination is not Clearly Defined
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`As a preliminary matter, we find the proposed combination of Quake,
`
`Dale, and Chien is not clearly defined. Petitioner asserts that it would have
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`14
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`been “obvious that multiple instances of Quake’s droplet generator should
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`be disposed on a single chip,” as depicted in the figures from Quake and
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`Dale. Pet. 19 (emphases omitted); Ex. 1003 ‘H 66 (“Thus, in my view it was
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`obvious that multiples of Quake’s emulsion generating units could be
`
`arranged on a single plate or chip as shown below .
`
`.
`
`. .”). From this
`
`statement, it appears that Petitioner proposes to parallelize only Quake’s
`
`droplet generators on a single chip. Indeed, this is the combination of
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`elements Patent Owner addresses and criticizes in the Preliminary Response.
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`Prelim. Resp. 28 (“Why would a POSA take just a portion of the multi-
`
`layered Quake device and attempt to replicate solely that portion in parallel
`
`in the single-layered chips of Dale?”).
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`Other portions of the Petition, however, appear to contemplate
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`incorporating the entire Quake design, from inlet to outlet, on the plate of
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`Dale and/or Chien. Pet. 17 (“Because droplets produced by the emulsion
`
`generators are transmitted to the analysis units .
`
`.
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`. one skilled in the art
`
`would have appreciated that high throughput is more readily accomplished
`
`using multiple droplet generators”), 36 (citing Ex. 1004 111] 71 (discussing
`
`the use of a “discrimination region” and associated detection regions in
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`Quake), 77 (discussing the orientation of channels, detection regions, and
`
`wells or reservoirs in Quake’s “[s]orter embodiments”)); Ex. 1003 11 60 (Dr.
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`Gandhi contemplating the use of “multiple droplet generators feeding
`
`multiple analysis units” based on Quake’s disclosures).
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`Petitioner’s vaguely and inconsistently defined combination, of
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`elements is not sufficient to allow for a reasoned analysis of the proposed
`
`combination or to allow proper consideration of whether one of ordinary
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`skill in the art would have had a reasonable expectation of success in
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`15
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`combining the teachings of the prior art references to arrive at the claimed
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`invention. Pet. 27 (addressing only whether one of ordinary skill in the art
`
`would have had a reasonable expectation of success in including an array of
`
`emulsion production units on a single chip). This counsels against
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`institution of review.
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`b. Parallelizing Quake in view of both Quake and Dale
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`Petitioner contends that, because it was well known in the art that
`
`parallelizing microfluidic circuits increases throughput, one of ordinary skill
`
`in the art would have found it obvious to provide a parallel array of Quake’s
`
`droplet generators on a single microfluidic chip. Pet. 18 (citing Ex. 1005
`
`1144; Ex. 1008 11 20; Ex. 1028, 12; Ex. 1012, 1—2; Ex. 1013 1111 92—93, 239;
`
`Ex. 1014 1] 75, Fig. 2). Petitioner further contends that, because Quake
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`specifically suggests that providing multiple units on a single chip enables
`
`multiplexed processing of different samples, or the same sample by different
`
`processes, one of ordinary skill in the art would have been motivated “to use
`
`the teChnique taught in Dale (parallelization) to improve a similar device
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`(Quake’s microfluidic device) in the same way (permit multiplex
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`processing)” Id. at 18—19 (citing KSR, 550 US. at 415—421; Ex. 1003
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`1111 60—65).
`
`Quake discloses implementing a linear array of channels and a
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`“plurality of analysis units" on a single chip to provide a “multiplex system.”
`
`Ex. 1004 11 79 (disclosing that “linear arrays of channels on a single chip,
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`i.e., a multiplex system, can simultaneously detect and sort a sample by
`
`using an array of photo multiplier tubes (PMT) for parallel analysis of
`
`different channels”). Quake also teaches or suggests providing multiple
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`droplet generators on the chip. Id. 11 314 (disclosing that embodiments of the
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`16
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`invention may “contain a plurality of droplet extrusion regions”); Ex. 1003
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`1] 60 (testifying that “Quake discloses parallelizing the emulsion generating
`
`units”). Given that Quake already provides for a multiplexed system having
`
`parallelized emulsion generating units, we are not persuaded that one of
`
`ordinary skill in the art would have modified Quake in view of Dale in order
`
`to obtain these same features.
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`Moreover, to the extent Petitioner contends an ordinary artisan would
`
`have sought to incorporate only the droplet generators of Quake on a single
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`chip, without the analysis units and/or sorting channels, it is not evident why
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`such a modification would have improved Quake’s device, which is
`
`designed for analyzing and/or sorting biological materials. Ex. 1004 1] 4,
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`Abstract (“A microfluidic device for analyzing and/or sorting biological
`
`materials .
`
`.
`
`. and methods for its use are provided”); Pet. 19 (asserting that
`
`one of ordinary skill in the art would have sought to use Dale’s
`
`parallelization technique “to improve .
`
`.
`
`. Quake’s microfluidic device”).
`
`In view of the foregoing, Petitioner has not demonstrated sufficiently
`
`that one of ordinary skill in the art would have sought to modify Quake in
`
`View of Dale.
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`(2. Use ofChien ’s Plate and Pressure Control System
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`As noted above, Quake teaches driving fluids through its system using
`
`syringes pressurized with air. Ex. 1004 1] 288. Petitioner provides three
`
`reasons why it contends one of ordinary skill in the art would have sought to
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`abandon Quake’s fluid drive system and adopt Chien’s multi-reservoir plate
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`and pressure control system. Pet. 25—26.
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`First, Petitioner contends one of ordinary skill in the art would have
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`abandoned Quake’s pressurized air and syringe system in favor of “Chien’s
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`multi-reservoir plate and pressure control system,” in view of Chien’s
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`disclosure that “‘the use of external pumps to force liquids directly through
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`microfluidic channels’ produces ‘irreproducible and erratic results
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`and in
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`view of Chien’s disclosure that the use of a compressible gas at the fluid-air
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`interface on the top of the wells “is a more practical design.” Pet. 25
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`(quoting Ex. 1035, 106).
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`Consistent with Petitioner’s assertions, Chien indicates that accurate
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`control of flow rate in microfluidic systems is extremely difficult and that a
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`lack of proper control of small pressure differences will yield irreproducible
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`and erratic results. Ex. 1035, 106. Chien does not disclose, however, that
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`all external pumps yield irreproducible and erratic results in microfluidic
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`systems, and neither Petitioner nor Dr. Gandhi asserts that Quake’s system
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`suffers from a lack of pressure control or from irreproducible and erratic
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`results. Indeed, any suggestion that Quake’s system lacks sufficient pressure
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`control would appear to be expressly contradicted by Quake itself, which
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`explains that the frequency of droplet production is “readily adjusted by
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`simply adjusting the pressures of the individual fluid lines.” Ex. 1004
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`1111 290, 296 (“As demonstrated here, the size and frequency of droplets
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`formed in a main channel of such devices may be precisely controlled by
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`modifying the relative pressure of the incompatible fluids (e.g., water and
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`oil) in the device”); see also id 1] 79 (“Microfluidic pumps and valves are a
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`preferred way of controlling fluid and sample flow.”). Thus, Petitioner has
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`not demonstrated sufficiently that Chien’s disclosures would have motivated
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`one of ordinary skill in the art to use Chien’s plate and pressure control
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`system to drive fluid droplet generation in the emulsion generators of Quake.
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`Second, Petitioner argues that modifying Quake to use Chien’s fluid
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`drive system would allow an ordinary artisan to omit Quake’s external fluid
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`reservoirs and pumps, which Dr. Gandhi testifies are expensive and need
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`periodic cleaning. Pet. 26; Ex. 1003 ‘H 75 (“Eliminating tubing and pumps
`reduces cost and greatly reduces the risk of contamination”). We are not
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`persuaded by this argument because, as noted by Patent Owner, Quake
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`discloses that “the sorting devices of the invention are inexpensive and
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`disposable, which obviates the need for cleaning and sterilization and
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`prevents cross—contamination.” Ex. 1004 1] 14; Prelim. Resp. 30.
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`Third, Petitioner argues that a skilled artisan would have been
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`“strongly inclined to improve the Quake device” by implementing Chien’s
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`fluid drive system, because “the syringe pumps, tubing, and wells of the
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`Chien device were configured in a similar manner to Quake’s.” Pet. 26. As
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`Patent Owner notes, however, a general similarity in structure or design
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`between two devices is not a reason, in itself, to combine them. Prelim.
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`Resp. 30—31. Thus, we are not persuaded that an alleged similarity in
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`configuration is sufficient to demonstrate that one of ordinary skill in the art
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`would have been motivated to combine Quake and Chien.
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`In view of the foregoing, Petitioner has not explained sufficiently why
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`one of ordinary skill in the art would have sought to implement multiple
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`versions of Quake’s droplet generators on the plate of Dale and/or Chien, or
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`why an ordinary artisan would have then sought to use Chien’s pressure
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`control system to drive fluids through Quake’s droplet generators.
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`Accordingly, Petitioner has not demonstrated a reasonable likelihood that
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`independent claim 1 would have been obvious over the combined
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`disclosures of Quake, Dale, Chien I, and Chien II.
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`Because claims 2—6, 8, 10, 11, and 21 depend from claim 1, and
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`because Petitioner’s arguments and evidence with respect to these claims do
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`not remedy the defects identified above, Petitioner also has not demonstrated
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`a reasonable likelihood that these claims would have been obvious over the
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`combined disclosures of Quake, Dale, Chicn I, and Chien II.
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`C. Remaining Grounds Based on Quake, Dale, Chien I, and Chien II
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`Petitioner’s remaining challenges to dependent claims 7, 9, and 12—20
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`require modification of the Combined System formed from Quake, Dale,
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`Chien I, and Chien 11. Pet. 52, 54, 57, 69. Petitioner’s arguments with
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`respect to these remaining challenges do not resolve the deficiencies noted
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`above with respect to the combined teachings of Quake, Dale, Chien I, and
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`Chien TI. Accordingly, Petitioner has not demonstrated a reasonable
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`likelihood that dependent claims 7, 9, and 12—20 would have been obvious
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`over the teachings of Quake, Dale, Chien I, Chien II in combination with
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`Hsieh, Modlin, Soane, or Beer.
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`111,
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`CONCLUSION
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`For the reasons discussed above, Petitioner has not demonstrated a
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`reasonable likelihood that it would prevail with respect to at least one claim
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`challenged in the Petition. Accordingly, we do not institute inter partes
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`revicw.
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`IV. ORDER
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`It is hereby,
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`ORDERED that no inter partes review is instituted.
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`IPR2018-00301
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`Patent 9,216,392 B2
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`PETITIONER:
`
`Greg Gardella
`Natalie J. Grace
`
`GARDELLA GRACE P.A.
`
`ggardella@gardellagrace.com
`ngrace@gardellagrace.com
`
`Sarah Brashears
`
`CONVERGENT LAW GROUP LLP
`
`Ddevore@convergentlaw.com
`
`David J. Ball
`
`.
`
`PAUL, WEISS, RIFKIND, WHARTON & GARRISON LLP
`dball@paulweiss.com
`
`PATENT OWNER:
`
`James M. Glass
`
`Kevin Johnson
`
`Joseph Milowic III
`David Bilsker
`
`Nancy Zhang
`QUINN EMANUEL URQUHART & SULLIVAN
`jimglass@quinnemanuel.com
`kevinjohnson@quinnemanuel.com
`josephmilowic@quinnemanuel.com
`davidbilsker@quinnemanuel.com
`nancyzhang@quinnemanuel.com
`
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`