`
`U.S. PATENT DOCUMENTS
` Examiner Cite
`Publication Date
`Name of Patentee or
`
`Initials*
`No.1
`Document Nuzmber
`MM-DD-YYYY
`Number-Kind Code (sznawn)
`
`Pages, Columns, Lines, Where
`RelevantIPassages or Relevant
`Figures Appear
`
`
`
`Receipt date: 11/09/2032
`
`32954634 ~ GAR): 1637
`PTO/SB/08a (07-09)
`Approved for use through 07/31/2012. OMB 0651-0031
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons required to respond to a collection of information unless it contains a valid OMB control number.
`
`Substitute for form 1449/PTO
`
`Application Number
`
`Complete ifKnown
`12/954,634
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`(Use as many sheets as necessary)
`
`NOVember 25» 2010
`Benjamin Hindson
`1637
`
`01000000. 00000000
`
`Sheet
`
`Attorney Docket Number
`
`3 8938-705.201
`
`
`
`--—_—
`-_——
`;-_——
`‘r-n_——
`
`FOREIGN PATENT DOCUMENTS
`
`Examiner
`Initials*
`
`.
`
`Foreign Patent Document
`
`Country Code , Number , Kind Code (sznown)
`
`Publication Date
`MM-DD-YYYY
`
`Name of Patentee or
`Applicant of Cited Document
`
`Pages, Columns, LiIICS,
`Where RClCVaflt Passages
`Or ReleVant Figures Appear
`
`T6
`
`/0.0./
`
`.
`
`EP 1644519 B1
`
`12/31/2008
`
`Todd et a1.
`
`/O.O./EW02012/116331A2
`
`0000/2012 _—
`
`Continued on the next page with more references.
`
` Examiner
`
`,
`,
`_4
`.
`.
`,
`11/28/2012
`/Qaavmka D 6 WV
`Initial ifreference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include copy
`*EXAMINER:
`ofthis form with next communication to applicant. 1Applicant’s unique citation designation number (optional). 2See Kinds Codes ofUSPTO Patent Documents at 32033133741475in4.593 or MPEP
`901.04. 3Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). 4For Japanese patent documents, the indication ofthe year ofthe reign ofthe Emperor must
`precede the serial number ofthe patent document. 5Kind of document by the appropriate symbols as indicated on the document under WIPO Standard ST.16 ifpossible. 6Applicant is to place a
`check mark here if English language Translation is attached.
`This collection of information is required by 37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an
`application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the
`completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount oftime you require to complete this form and/or suggestions for
`reducing this burden, should be sent to the ChiefInformation Officer, U.S. Patent and Trademark Office, P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED
`FORMS TO THIS ADDRESS. SEND TO: Commissioner for Patents, PO. Box 1450, Alexandria, VA 22313-1450.
`Ifyoa need assistance in completing theform, call l-800—PTO-9l99 (1-800- 786-9199) and select option 2.
`
`Date
`
`Attorney Docket No. 38938-705201
`
`- 1 -
`
`521135571.D0CX
`
`ALL REFERENCES CONSlEEREE EXCEPT WHERE LINES THROUGH. /0.0./
`
`

`

`Receipt date: wee/2012
`
`Application Number
`
`Complete ifKnown
`12/954,634
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`
`Filing Date
`
`First Named Inventor
`
`November 25, 2010
`
`Benjamin Hindson
`1637
`
`claim. (We...
`
`t2954634 ~ GAR): 1637
`PTO/SB/08b (07-09)
`Approved for use through 07/31/2012. OMB 0651-0031
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons required to respond to a collection of information unless it contains a valid OMB control number.
`
`Substitute for form 1449/PTO
`
`
`
`
`
`
`
`
`
`
`
`(Use as many sheets as necessary)
`
`
`
`
`Attorney Docket Number
`
`3 893 8-705 .201
`
`
`
`
`NON PATENT LITERATURE DOCUMENTS
`Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title of the
`item (book, magazine, journal, serial, symposium, catalog, etc.), date, page(s), volume-issue number(s),
`publisher, city and/or country where published.
`
`CAUGHEY, et a1. Chorionic villus sampling compared with amniocentesis and the
`difference in the rate ofpregnancy loss. Obstet Gynecol. 2006 Sep;108(3 Pt 1):612-6.
`
`CHAN, et a1. Hypermthylated RASSFlA in maternal plasma: A universal fetal DNA
`marker that improves the reliability of noninvasive prenatal diagnosis. Clin. Chem.
`2006; 52(12):2211-2218.
`
`D'ALTON. Prenatal diagnostic procedures. Semin Perinatol. 1994 Jun;18(3):140-62.
`
`DHALLAN, et a1. Methods to increase the percentage of free fetal DNA recovered from
`the maternal circulation. JAMA. 2004 Mar 3;291(9):1114-9.
`
`;;
`
`International search report and written opinion dated 08/03/2012 for
`PCT/U82012/025760.
`
`15
`
`International search report and written opinion dated 08/03/2012 for
`PCT/U82012/024573.
`
`MILBURY, et a1. PCR-based methods for for the enrichment of minority alleles and
`mutations. Clin. Chem. 2009, 55(4):632- 640.
`
`NICOLAIDIS, et a1. Origin and mechanisms of non-disjunction in human autosomal
`trisomies. Hum Reprod. 1998 Feb;13(2):313-9.
`
`TSUI, et a1. Epigenetic approaches for the detection of fetal DNA in maternal plasma.
`Chimerism. 2010 Jul;1(1):30-35.
`
`
`
`Examiner
`[I’Oan-iplka Oyeyemi/
`Date.
`1 11/28/2012
`
`Slgnature
`Cons1dered
`*EXAMINER:
`Initial ifreference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. Include copy
`ofthis form with next communication to applicant.
`1Applicant’s unique citation designation number (optional). 2Applicant is to place a checkrnark here if English language Translation is attached.
`This collection of information is required by 37 CFR 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the USPTO to process) an application.
`Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including gathering, preparing, and submitting the completed application
`form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of time you require to complete this form and/or suggestions for reducing this burden,
`should be sent to the Chief Information Officer, U.S. Patent and Trademark Office, P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS
`ADDRESS. SEND TO: Commissioner for Patents, PO. Box 1450, Alexandria, VA 22313-1450.
`Ifyoa need assistance in completing theform, call l-800—PTO-9l99 (1-800- 786-9199) and select option 2.
`
`Attorney Docket No. 38938-705201
`
`- 2 -
`
`521135571.D0CX
`
`ALL REFERENCES CONSlEEREE EXCEPT WHERE LiNEE) THROUGH. /0.0./
`
`