`
`Please replace paragraph 0430 with the following rewritten paragraph.
`
`[0430] Gram-positive Eubacteria cell walls generally 0% to 2% lipid. However, certain
`
`categories of Gram-positive Eubacteria can comprise up to 50% or more lipid content as part of
`
`the cell wall: Such Eubacteria include different species of Gordom'a, Mycobacterium, Nocardia,
`and Rhodococcus. Additionally, the lipids of such Eubacreria generally comprise a branched
`
`chain fatty acid, particularly mycolic acids (Barry, C. E. et al., Prog Lipid Res 37:143, 1998). It
`
`is though that mycolic acids are covalently bound or loosely associated-associated with cell wall
`
`sugars. The type of Eubacteria is sometimes used to identify the carbon-backbone length of the
`
`mycolic acids. For example, an eumycolic acid is isolated from a Mycobacterium, and generally
`
`comprises 60 to 90 carbon atoms. A corynomycolic acid is isolated from a Corynobacterium,
`
`and generally comprises 22 to 36 carbons. A nocardomycoic acid is isolated from a Nocardia,
`
`and generally comprises 44 to 60 carbons. http—pllwweybeH-Ifid—ergvlaeeiml—htm
`
`WWWA mycolic acid generally comprises a fatty acid
`
`branch (“alpha branch”) and an aldehyde (“meromycolate branch”). A mycolic acid may further
`
`comprise a carbon double bond, an epoxy ester moiety, a cyclopropane ring moiety, a keto
`
`moiety, a methoxy moiety or a combination thereof, generally located on meromycolate branch.
`
`A mycolic acid may comprise an a-mycolic acid, a methoxymyColic acid, a ketomycolic acid, an
`
`epoxymycolic acid, a wax ester or a combination thereof. A a-mycolic acid comprises a cis or
`
`trans carbon double bond and/or a cyclopropane, and may further comprise a methyl branch
`
`adjacent to such a moiety. A methoxymycolic acid comprises a methoxy moiety and a double
`
`bond or a cyclopropane. A ketomycolic acid comprises a-methyl-branched ketone. An
`
`epoxymycolic acid comprises an a-methyI-branch epoxide. A wax ester comprises an internal
`
`ester group and a carbon double bond or a cyclopropane ring.
`
`2/61
`
`
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