Trademark Trial and Appeal Board Electronic Filing System. http://estta.uspto.gov
`ESTTA793171
`01/04/2017
`
`ESTTA Tracking number:
`
`Filing date:
`
`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`BEFORE THE TRADEMARK TRIAL AND APPEAL BOARD
`
`Notice of Opposition
`
`Notice is hereby given that the following party opposes registration of the indicated application.
`
`Opposer Information
`
`Name
`
`Gilead Sciences, Inc.
`
`Granted to Date
`of previous ex-
`tension
`
`Address
`
`Attorney informa-
`tion
`
`01/04/2017
`
`333 Lakeside Dr.
`Foster City, CA 94401
`UNITED STATES
`
`Lori F Mayall
`Gilead Sciences, Inc.
`333 Lakeside Dr.
`Foster City, CA 94401
`UNITED STATES
`trademarks@gilead.com, lori.mayall@gilead.com Phone:650-378-2184
`
`Applicant Information
`
`Application No
`
`86974388
`
`Publication date
`
`09/06/2016
`
`Opposition Filing
`Date
`
`Applicant
`
`01/04/2017
`
`Opposition Peri-
`od Ends
`
`01/04/2017
`
`Vir Biotechnology, Inc.
`c/o ARCH Venture Partners
`Chicago, IL 60631
`UNITED STATES
`
`Goods/Services Affected by Opposition
`
`Class 005. First Use: 0 First Use In Commerce: 0
`All goods and services in the class are opposed, namely: Anti-viral drugs
`
`Grounds for Opposition
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`The mark is merely descriptive
`
`Trademark Act Section 2(e)(1)
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`The mark is generic
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`Trademark Act Sections 1, 2 and 45
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`Attachments
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`NOO re VIR.BIO Final w Exhibits.pdf(826233 bytes )
`
`Certificate of Service
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`The undersigned hereby certifies that a copy of this paper has been served upon all parties, at their address
`record by First Class Mail on this date.
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`

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`Signature
`
`/lfm/
`
`Name
`
`Date
`
`Lori F Mayall
`
`01/04/2017
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`BEFORE THE TRADEMARK TRIAL AND APPEAL BOARD
`
`In the matter of applications Serial No. 86/974,388
`For the Trademark VIR.BIO
`Published in the Official Gazette on September 6, 2016
`
`Opposition No.
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`GILEAD SCIENCES, INC.,
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`Opposer,
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`VIR BIOTECHNOLOGY, INC.,
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`Applicant.
`__________________________________________)
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`NOTICE OF OPPOSITION
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`Opposer Gilead Sciences Inc. (“Gilead” or “Opposer”), a Delaware corporation having its
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`
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`principal place of business at 333 Lakeside Dr., Foster City, California 94404, believes that it
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`will be damaged by the issuance of registration for the trademark VIR.BIO (the “VIR.BIO
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`Mark” or “Applicant’s Mark”), as applied for in Application Serial No. 86/974,388, filed on
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`April 13, 2016 by Vir Biotechnology, Inc. (“Applicant”) on an intent-to-use basis. Applicant is,
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`upon information and belief, a Delaware corporation with a mailing address of c/o ARCH
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`Venture Partners, 8725 W. Higgins Rd., Suite 290, Chicago, Illinois 60631.
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`
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`As grounds for opposition, Gilead alleges that:
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`1.
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`Gilead is one of the world’s largest biopharmaceutical companies, dedicated to
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`discovering, developing and marketing medications to treat a variety of human diseases, ranging
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`from HIV to liver disease to cardiovascular disease and other infectious diseases, as well as other
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`areas of unmet medical need.
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`

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`2.
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`Gilead commercializes antiviral drugs such as TRUVADA® (emtricitabine/
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`tenofovir disoproxil fumarate), GENVOYA® (elvitegravir/cobicistat/emtricitabine/tenofovir
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`alafenamide), and HARVONI® (ledipasvir/sofosbuvir).
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`3.
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`On April 13, 2016, Applicant filed an application for the mark VIR.BIO for:
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`“Anti-viral drugs” in class 5 on an intent-to-use basis (“Applicant’s Application”).
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`4.
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`Applicant’s Mark was published in the Official Gazette on September 6, 2016,
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`and Opposer has timely filed for, and the Trademark Trial and Appeal Board has granted, an
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`extension of time to file an opposition until January 4, 2017.
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`5.
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`“VIR” is a frequently-used stem appearing in international nonproprietary names
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`(INNs) (also known as “generic names”) and designates that the particular pharmaceutical
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`compound is an antiviral. See Exhibit A, page 8.
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`6.
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`INNs adopted by the World Health Organization for antiviral drugs contain the “-
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`VIR-” stem, such as entecavir, paritaprevir, sofosbuvir and tenofovir.
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`7.
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`8.
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`9.
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`“VIR” means antiviral.
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`“VIR” lacks distinctiveness when used in connection with antiviral drugs.
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`“BIO” is commonly used as an abbreviation for “biotechnology.”
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`10.
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`Antiviral drugs are a common category of products developed by biotechnology
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`companies.
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`11.
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`“BIO” is also commonly used as an abbreviation for “biological,” which is
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`defined as “[a] therapeutic substance, such as a vaccine or drug, derived from biological
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`sources.” See Exhibit B, page 2.
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`12.
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`“.BIO” is a top level domain (TLD) used for life sciences websites, including
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`websites relating to biology and biotechnology.
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`

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`13.
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`On information and belief, Applicant registered the domain name <vir.bio> to be
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`used in connection with its anti-viral drug company.
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`14.
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`TLDs function to indicate an address on the World Wide Web, and, therefore,
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`generally serve no source-indicating function. TMEP 1209.03(m).
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`15.
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`“.BIO” is generic and lacks distinctiveness when used in connection with antiviral
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`drugs.
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`16.
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`The terms in Applicant’s Mark, “VIR” and “.BIO,” retain their generic, or, at
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`most, descriptive significance in relation to antiviral drugs.
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`17.
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`Applicant’s Mark, if used in connection with “anti-viral drugs” would be generic,
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`or, at most, merely descriptive of such goods.
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`18.
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`If Applicant obtains the registration herein opposed, it would obtain a prima facie
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`exclusive right to use the VIR.BIO Mark.
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`19.
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`If Applicant obtains the registration herein opposed, Opposer (and others) would
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`be damaged and injured as its use of “Vir Bio” or a similar term that incorporates the generic
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`terms “vir” and/or “bio” to accurately describe and/or identify its antiviral drugs may subject it to
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`an infringement suit.
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`20.
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`Registration should, therefore, be refused pursuant to Section 2(e)(1) of the
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`Trademark Act of 1946, as amended, 15 U.S.C. § 1052(e)(1), on the grounds that Applicant’s
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`VIR.BIO Mark is generic, or, at best, merely descriptive.
`
`//
`
`//
`
`

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`WHEREFORE, Opposer prays that said application Serial No. 86/974,388 be rejected,
`
`that no registration be issued, and that this Opposition be sustained in favor of Opposer. This
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`Notice of Opposition is submitted electronically.
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`Respectfully submitted,
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`By: /s/ Lori F. Mayall
` Lori F. Mayall, Esq.
` Gilead Sciences, Inc.
` 333 Lakeside Dr.
` Foster City, CA 94404
` (650) 378-2184 telephone
` (650) 578-9264 telefax
` lori.mayall@gmail.com
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`Date: January 4, 2017
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`CERTIFICATE OF TRANSMITTAL AND SERVICE
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`I hereby certify that this Notice of Opposition is being electronically transmitted in PDF
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`
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`format to the Trademark Trial and Appeal Board through the Electronic System for Trademark
`
`Trials and Appeals (ESTTA) on the date indicated below.
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`
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`I hereby further certify that on the date indicated below, a true and correct copy of this
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`Notice of Opposition was placed in the United States Mail, postage prepaid, addressed to the
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`applicant and the correspondent for the subject application listed in the USPTO’s online database
`
`as follows:
`
`Vir Biotechnology, Inc.
`c/o ARCH Venture Partners
`8725 W. Higgins Rd., Suite 290
`Chicago, Illinois 60631
`
`
`and
`
`Maya L Tarr
`Proskauer Rose LLP
`Eleven Times Square
`New York, NY 10036-8299
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`Date: January 4, 2017
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`/s/ Lori F. Mayall_________
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`Lori F. Mayall
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`

`

`Exhibit A
`Exhibit A
`
`

`

`1f.tl2017
`
`Canmm S111ma fer lntllrnallonal NOI'li'OP"Ielary Namaa (IN Na) - Druga.ccm
`
`International Nonproprietary Names (INNs)- Common
`Stems
`
`List of Common Stems Used in the Selection of INNs
`
`Browse: A B C D E F G H I J K L M N 0 P Q R S T U V W X Y Z
`
`Stem
`
`Definition & substem (If available)
`
`A
`-ac
`-actide
`-adol or-
`adol(cid:173)
`-adom
`-afenone
`-aj-
`-aldrate
`-a lox
`-amivir see
`vir
`andr
`-anserin
`-antel
`-a pine
`-arabine
`-arit
`
`-arol
`art e(cid:173)
`-ase
`
`-ast
`
`-astine
`-azenil
`-azepam
`-azepide
`-azocine
`-azoline
`-azosin
`
`B
`
`anti-inflammatory agents, ibufenac derivatives
`syn1hetic polypeptides with a corticotrophin-like action
`analgesics
`
`analgesics, tifluadom derivatives
`antiarrhythmics, propafenone derivatives
`antiarrhythmics, ajmaline derivatives
`antacids, aluminium salts
`antacids, aluminium derivatives
`
`steroids, androgens
`serotonin receptor antagonists (mostly 5-HT 2)
`anthelminthics (underfined group)
`see -pine
`arabinofuranosyl derivatives
`antiarthritic substances, acting like clobuzarit and lobenzarit (mechanism different from anti(cid:173)
`inflammatory type substances, eg -fenamates or -profens)
`anticoagulants, dicoumarol derivatives
`antimalarial agents, artemisinin related compounds
`enzymes;
`-dismase (superoxide dismutase activity),
`-pase (lipase)
`-teplase (tissue plasminogen activators),
`-uplase (urokinase-type-plasminogen activators)
`antiasthmatic, antiallergics, not acting primarily as antihistaminics;
`-lukast (leukotriene receptor antagonist);
`-trodast (thromboxane A2 receptor antagonists, antiasthmatics)
`antihistaminics
`benzodiazepine receptor antagonists/agonist& (benzodiazepine derivatives)
`diazepam derivatives
`cholecystokinin receptor antagonist
`narcotic antagonists/agonists related to 6, 7 -benzomorphan
`antihistaminics or local vasoconstrictors, antazoline derivatives
`antihypertensive substances, prazosin derivatives
`
`t-..ps:/1Www.drugs.canl1m-stama.hbnl#v
`
`118
`
`

`

`1/412017
`
`Common SIBms fer lniBrnalional Nonpropriela'y Names (INNs)- Drugs.com
`
`-bactam
`-bam ate
`barb
`-bendazole
`bol
`-bradine
`-buzone
`
`b-lactamase inhibitors
`tranquillizers, propanediol and pentanediol derivatives
`hypnotics, barbituric acid derivatives
`anthelminthics, tiabendazole derivatives
`anabolic steroids
`bradycardic agents
`anti-inflammatory analgesics, phenylbutazone derivatives
`
`c
`-cain-
`
`-caine
`calci
`-carbef
`-carnil
`-cavir
`cef-
`cell- or eel(cid:173)
`or -cell-
`
`-cic
`-cidin
`-cillin
`-citabine
`-clone
`-cog
`
`-conazole
`cort
`-crinat
`-crine
`-cromil
`-curium
`-cycline
`
`D
`-dan
`-dapsone
`-dermin
`-dil
`-dipine
`-dismase
`-dopa
`-dox
`-dralazine
`-drine
`
`-dronic acid
`
`Class 1 antiarrhythmics, procainamide and lidocaine derivatives (antifibrillants with local anaesthetic
`activity)
`local anaesthetics
`Vitamin D analogues/derivatives
`antibiotics, carbacepham derivatives
`benzodiazepine receptor antagonists/agonists (carboline derivatives)
`see vir
`antibiotics, cefalosporanic acid derivatives
`cellulose derivatives
`cell-ate (cellulose ester derivatives);
`-cellose (cellulose ether derivatives)
`hepatoprotectice substances with a carboxylic acid group
`naturally occurring antibiotics (undefined group)
`antibiotics, 6-aminopenicillanic acid derivatives
`nucleoside antiviral or antineoplastic agents, cytarabine or azarabine derivatives
`hypnotic tranquillizers
`blood coagulation factors;
`(-)eptacog (blood coagulation VII);
`(-)octocog (blood coagulation factor VIII);
`(-)nonacog (blood coagulation factor IX)
`systemic antifungal agents, miconazole derivatives
`corticosteroids, except prednisolone derivatives
`diuretics, etacrynic acid derivatives
`acetylcholinesterase inhibitors, tacrine derivatives
`antiallergics, cromoglicic acid derivatives
`see -ium
`antibiotics, tetracycline derivatives
`
`cardiac stimulants, pimobendan derivatives
`Antimycobacterials, diaminodiphenylsulfone derivatives
`see -ermin
`vasodilators
`calcium channel blockers, nifedipine derivatives
`see -ase
`dopamine receptor agonists, dopamine derivatives, used as antiparkinsonism/prolactin inhibitors;
`antibacterials, quinoline dioxide derivatives
`antihypertensives, hydrazinephthalazine derivatives
`sympathomimetics;
`-frine: sympathomimetic, phenethyl derivatives
`calcium metabolism regulator, pharmaceutical aid
`
`htlps://www.ctugs.com{lnr>-stems.html#v
`
`218
`
`

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`1/412017
`
`E
`-ectin
`-entan
`-eptacog
`erg
`-eridine
`-ermin
`
`estr
`-etanide
`-exakin
`-exine
`
`F
`-fenamic
`acid
`-fen in
`-fenine
`-fentanil
`-fermin
`-fiban
`-fibrate
`-flapon
`-flurane
`-form in
`-fos (-vas)
`-fos- or fos-
`-fradil
`-frine
`-fungin
`-fylline
`
`G
`gab
`gado(cid:173)
`-gatran
`gest
`-giline
`-gill in
`gli
`-golide
`
`Common SIBms fer lniBrnalional Nonpropriela'y Names (INNs)- Drugs.com
`
`antiparasitics, ivermectin derivatives
`endothelin receptor antagonists
`see-cog
`ergot alkaloid derivatives
`analgesics, pethidine derivatives
`growth factors;
`-dermin (epidermal growth factors);
`-fermin (fibrinoblast growth factors);
`-nermin (tumour necrosis factor);
`-sermin (insulin-like growth factors)
`estrogens
`diuretics, piretanide derivatives
`see -kin
`mucolytic, bromhexine derivatives
`
`anti-inflammatory, anthranilic acid derivatives
`-fenamate ("-fenamic acid" derivatives)
`diagnostic aids; (phenylcarbamoyl)methyl iminodiacetic acid derivatives
`analgesics, glafenine derivatives- (subgroup offenamic acid group)
`narcotic analgesics, fentanil derivatives
`see-ermin
`Fibrinogen receptor antagonists (glycoprotein lib/lila receptor antagonists
`clofibrate derivatives
`5-lipoxygenase-activating protein (FLAP) inhibitor
`general inhalation anaesthetics, halogenated alkane derivatives
`antihyperglycaemics, phenformin derivatives
`insecticides, anthelmintics,pesticides etc., phosphorous derivatives
`various pharmacological categories belonging to -fos (other than above)
`calcium channel blockers acting as vasodilators
`see -drine
`antifungal antibiotics
`N-methylated xanthine derivatives
`
`gabamimetic agents
`diagnostic agents, gadolinium derivatives
`thrombin inhibitor, antithrombotic agents
`steroids, progestogens
`MAO-inhibitors type B
`antibiotics produced by Aspergillus strains
`antihyperglycaemics, sulfonamide derivatives
`dopamine receptor agonists, ergoline derivatives
`
`-gramostim see -stim
`-grastim
`see -stim
`-grel- or -grelplatelet aggregation inhibitors
`guan-
`antihypertensives, guanidine derivatives
`
`H&l
`-icam
`
`anti-inflammatory, isoxicam derivatives
`
`htlps://www.ctugs.com{lnr>-stems.html#v
`
`318
`
`

`

`1/412017
`
`-ifene
`-ilide
`imex
`-imod
`-imus
`io-
`-io- or iod-
`-iptan
`
`-irudin
`-isomide
`-ium
`
`-izine
`
`J&K
`-kacin
`-kalant
`-kalim
`-kef-
`-kin
`
`-kinra
`
`-kiren
`
`L
`-leu kin
`-lipastat
`-Iukas!
`
`M
`-mab
`-mantadine
`
`-meline
`-mer
`-mesine
`-mestane
`-metacin
`-micin
`-monam
`-morelin
`-mostim
`-moline
`-moxin
`-mustine
`-mycin
`
`Common SIBms fer lniBrnalional Nonpropriela'y Names (INNs)- Drugs.com
`
`antiestrogens, clomifene and tamoxifen derivatives
`Class Ill antiarrhythmics, sematilide derivatives
`immunostimulants
`immunomodulators, both stimulant/suppressie and stimulant
`immunosuppressants (other than antineoplastics)
`iodine-containing contrast media
`iodine containing compounds other than contrast media
`serotonin (5HT 1) receptor agonists, sumatriptan derivatives
`hirudin derivatives
`antiarrhythmics, disopyramide derivatives
`quarternary ammonium compounds
`-curium (curare-like substances)
`diphenylmethyl piperazine derivatives
`-rizine (antihistaminics/cerebral (or peripheral) vasodilators)
`
`antibiotics, kanamycin and bekanamycin derivatives {obtained from Streptomyces kanamyceticus);
`potassium channel blockers
`potassium channel activators, antihypertensive
`enkephalin agonists
`interleukin type substances;
`-nakin (11-1 derivatives)
`-leukin (11-2 derivatives)
`-p/estim (11-3 derivatives)
`-exakin (11-6 derivatives)
`interleukin receptor antagonists;
`-nakinra (11-1 receptor antagonists)
`renin inhibitors
`
`see -kin
`see -stat
`see -ast
`
`monoclonal antibodies (for details please see page ..... )
`adamantine derivatives;
`-mantine, -mantone
`cholinergic agents, arecoline derivatives
`polymers
`sigma receptor ligands
`aromatase inhibitors
`anti-inflammatory, indometacin derivatives
`antibiotics obtained from various Micromonospora
`monobactam antibiotics
`see -relin
`see -stim
`antivirals, quinoline derivatives
`monoamine oxidase inhibitors, hydrazine derivatives •• not part of definition
`antineoplastic, alkylating agents, (b-chloroethyl) amine derivatives
`antibiotics, produced by Streptomyces strains
`
`htlps://www.ctugs.com{lnr>-stems.html#v
`
`418
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`

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`1/412017
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`Common SIBms fer lniBrnalional Nonpropriela'y Names (INNs)- Drugs.com
`
`N
`nab
`-nakin
`-nakinra
`nal(cid:173)
`-nercept
`-nermin
`nic
`-nicate
`-nidazole
`nifur(cid:173)
`-nixin
`-nonacog
`
`0
`-octocog
`-olol
`
`-alone
`
`-opamine
`-on ide
`-(o)nidine
`-orex
`orphan
`
`-oxacin
`-oxan(e)
`-oxanide
`-oxef
`-oxetine
`
`p
`
`-pafant
`-pam ide
`-pamil
`-parcin
`-parin
`-penem
`-peridol
`-peridone
`-perone
`
`-pidem
`-pin( e)
`
`cannabinol derivatives
`see -kin
`see -kinra
`narcotic antagonists/agonists related to normorphine
`tumour necrosis factor antagonist
`see -ermin
`nicotinic acid or nicotinoyl alcohol derivatives
`antihypercholesterolaemic and/or vasodilating nicotinic acid esters
`antiprotozoals, metronidazole derivatives
`5-nitrofuran derivatives
`anti-inflammatory, anilinonicotinic acid derivatives
`see -cog
`
`see -cog
`b-adrenoreceptor antagonists
`-alol: aromatic ring -CH-CH2-NH-R related to -olols
`steroids other than prednisolone derivatives
`
`dopaminergic agents dopamine derivatives used as cardiac stimulat/antihypertensives/diuretics
`steroids for topical use, acetal derivatives
`antihypertensives, clonidine derivatives
`anoretics
`narcotic antagonists/agonists, morphinan derivates;
`-orphine, -orphinol, orphone
`antibacterials, nalidixic acid derivatives
`benzodioxane derivatives
`antiparasitics, salicylanides and analogues
`antibiotics, oxacefalosporanic acid derivatives
`antidepressants, fluoxetine derivatives
`
`platelet-activating factor antagonists
`diuretics, sulfamoylbenzoic acid derivatives
`coronary vasodilators, verapamil derivatives
`glycopeptides antibiotics
`heparin derivatives including low molecular mass heparins
`analogues of penicillanic acid antibiotics modified in the five-membered ring
`see-perone
`see-perone
`tranquillizers, neuroleptics, 4' -fluoro-4-piperidinobutyrophenone derivatives;
`-peridot (antipsychotics, haloperidol derivatives);
`-peridone (antipsychotics, risperidone derivatives)
`hypnotics/sedatives, zolpidem derivatives
`tricyclic compounds
`-apine (psychoactive);
`-cilpine (antiepileptic);
`-dipine (see --dipine)
`-zepine (antidepressant/neuroleptic;
`
`htlps://www.ctugs.com{lnr>-stems.html#v
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`

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`1/412017
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`Common SIBms fer lniBrnalional Nonpropriela'y Names (INNs)- Orugs.com
`
`-piprazole
`-pirox
`-plan in
`-platin
`-plestim
`-pion
`
`-pramine
`-prazole
`pred
`
`-pressin
`-pride
`
`-pril(at)
`-prim
`-profen
`pros!
`
`-prostil
`
`Q
`-quinil
`
`R
`-racetam
`-relin
`
`-relix
`-renone
`-restat (or -
`restat-)
`retin
`-ribine
`rifa(cid:173)
`-rinone
`-rizine
`-rozole
`-rubicin
`
`s
`sal
`
`-sartan
`-semide
`-sermin
`-serpine
`-setron
`
`-oxepin, -oxopine, -sopine, -tepines
`psychotropics, phenylpiperazine derivatives
`antimycotic pyridine derivatives
`antibacterials (Actinoplanes strains)
`antineoplastic agents, platinum derivatives
`see-stim
`pyrazolo[-]pyrimidine derivatives, used as anxiolytics, sedatives, hypnotics
`-poetin erythropoietin type blood factors
`-porfin benzoporphyrin derivatives
`substances of the imipramine group
`antiulcer, benzimidazole derivatives
`prednisone and prednisolone derivatives;
`methazone or -metasone, -betaso/
`vasoconstrictors, vasopressin derivatives
`sulpiride derivatives
`
`angiotensin-converting enzyme inhibitors
`antibacterials, trimethoprim derivatives
`anti-inflammatory agents, ibuprofen derivatives
`prostaglandins;
`-prostil (prostaglandins, anti-ulcer)
`see -pros!
`
`benzodiazepine receptor partial agonists (quinoline derivatives)
`
`amide type nootrope agents, piracetam derivatives
`prehormones or hormone-release stimulating peptides;
`-more/in (growth hormone release-stimulating peptides);
`-tire/in (thyrotropin releasing hormone analogues)
`hormone-release inhibiting peptides
`aldosterone antagonists, spironolactone derivates
`see-stat
`
`retinol derivatives
`ribofuranil-derivatives of the pyrazofurin type
`antibiotics, rifamycin derivatives
`cardiac stimulants, amrinone derivatives
`see-izine
`aromatase inhibitors, imidozole-triazole derivatives
`antineoplastic antibiotics, daunorubicin derivatives
`
`salicylic acid derivatives:
`-sal-, salazo-, -salazine/-salazide, -satan
`angiotensin II receptor antagonists, antihypertensive (non-peptidic)
`diuretics, furosemide derivatives
`see-ermin
`derivatives of Rauwolfia alkaloids
`serotonin receptor antagonists (5-HT 3 ), not fitting into other established groups of serotonin receptor
`
`htlps://www.ctugs.com{lnr>-stems.html#v
`
`

`

`1/412017
`
`Common SIBms fer lniBrnalional Nonpropriela'y Names (INNs)- Drugs.com
`
`som(cid:173)
`-spirone
`-stan- or-
`ster(cid:173)
`-stat (or(cid:173)
`stat-)
`
`-steine
`-ster-
`
`-stim
`
`sulfa(cid:173)
`-sulfan
`
`T
`-tecan
`-tepa
`-teplase
`-terol
`
`-terone
`-tiazem
`-tide
`
`-tidine
`
`-tirelin
`-tizide
`-tocin
`-toin
`-trexate
`-tricin
`-triptyline
`-troban
`
`-trodast
`trop
`
`u
`-uplase
`-uracil
`-uridine
`
`v
`-vastatin
`
`antagonists
`growth hormone derivatives
`anxiolytics, buspirone derivatives
`steroids, androgens
`
`enzyme inhibitors:
`-lipastat (pancreatic lipase inhibitors);
`restat or -restat- (aldose-reducing inhibitors);
`-vastatin (antilipidemic substances, HMG CoA reductase inhibitors
`mucolytics, other than bromhexine derivatives
`androgens/anabolic steroids:
`-testosterone, -sterone, -ster-, -gesterone, -sterone, sterol, ster,
`-( a)steride( antineoplastics)
`colony stimulating factors:
`-grastim (granulocyte colony stimulatory factor (G-CSF) type) substances;
`-gramostim (granulocyte macrophage colony stimulating factor (GM-CSF) type substances);
`-mostim (macrophage stimulating factors (M-CSF) type substances);
`-p/estim (interleukin-3 analogues and derivatives)
`anti-infectives, sulfonamides
`antineoplastic, alkylating agents, methanesulfonates
`
`antineoplastics, topoisomerase I inhibitors
`antineoplastics, thiotepa derivatives
`see -ase
`bronchodilators, phenethylamine derivatives
`(previously -prenaline or -terenol)
`antiandrogens
`calcium channel blockers, diltiazem derivatives
`peptides and glycopeptides
`(for special groups of peptides see -actide, -pressin, -relin, -tocin)
`histamine H2-receptor antagonists, cimetidine derivatives
`see -relin
`diuretics, chlorothiazide derivatives
`oxytocin derivatives
`antiepileptics, hydantoin derivatives
`folic acid analogues
`antibiotics, polyene derivatives
`antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives
`thromboxane A2-receptor antagonists; antithrombotic agents
`see -ast
`atropine derivatives
`
`see -ase
`uracil derivatives used as thyroid antagonists and as antineoplastics
`uridine derivatives used as antiviral agents and as antineoplastics; also -udine
`
`see -stat
`
`htlps://www.ctugs.com{lnr>-stems.html#v
`
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`
`Common SIBms fer lniBrnalional Nonpropriela'y Names (INNs)- Drugs.com
`
`spasmolytics with a papaverine-like action
`-verine
`vin- or -vin- vinca alkaloids
`vir
`antivirals (underlined group):
`-amivir (neuraminidase inhibitors);
`-cavir (carbocyclic nucleosides);
`-virsen (antisense oligonucleotides)
`see vir
`antiviral; antineoplastics, zidovudine derivatives
`
`-virsen
`-vudine
`
`W&X
`-xanox
`
`antiallergic respiratory tract drugs, xanoxic acid derivatives
`
`Y&Z
`-zofone
`alozafone derivatives
`see -pine
`-zepine
`Return to International Nonproprietary Names.
`
`Explanatory notes:
`
`• The hyphens indicate the position of the stem, prefix, infiX or suffiX, within the INN. In the event that the hyphen is
`absent, the stem may be used in any position within the name.
`
`milo-
`
`-ol
`
`• The following common stems have been discontinued:
`Stem
`Definition
`mer- or -mer-mercury-containing drugs, antimicrobial or diuretic
`(deleted from General Principles in List 28 prop. INN)
`antineoplastics, nucleotoxic agents
`(deleted from General Principles in List 24 prop. INN)
`alcohols and phenols
`(deleted from General Principles in 14th report)
`-quine, quin quinoline derivatives
`(deleted from General Principles in List 28 prop. INN)
`anticholinesterases
`(deleted from General Principles in List 24 prop. INN)
`
`-stigmine
`
`htlps://www.ctugs.com{lnr>-stems.html#v
`
`818
`
`

`

`Exhibit B
`Exhibit B
`
`

`

`1f.Wll17
`
`DICTIONARY THESAURUS GRAMMAR
`
`EXPLORE
`
`BLOG
`
`Q siGNIN
`
`DICTIONARY (US)
`
`biological
`
`We use CIOOide:s to ･ｮｾｮ｣･＠your exper1ente on our website. By contlnulf1B to use our website. you ［ｾｲ･＠ｾＱＱＸ＠to our use of cookies. You wn cmnge your
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`CIOOide setllnasat anytime.
`
`CoMfNHI
`
`Rnd 01.1: mora
`
`: - - - - - -0>
`
`Home North American English biological
`
`NOUN
`
`The Oxford Dlc:tJonarfes Word of
`the Year 20161s. ••
`
`Definition of blologfcof In English:
`
`biological OOC0
`
`(also bioi.)
`
`ADJECTIVE
`
`1 Relating to biology or living organisms.
`
`Example sentence$
`
`Synonyms
`
`1.1 Relating to or involving the use of
`microorganisms or toxins of biological
`origin as weapons of war.
`
`BUY TICKETS
`
`Example sentences
`
`1..2 (of a detergent or other cleaning product)
`containing enzymes to assist the process
`of cleaning.
`
`Example sentences
`
`Synonyms
`
`2 (of a member of a person's family) genetically
`related; related by blood.
`
`'the rights of the biological father
`
`More example sentences
`
`DICTIONARY {US)
`
`biological
`
`l!lv Q
`
`MENU
`
`114
`
`

`

`1f.Wll17
`
`NOUN
`
`(usually bloloslcals)
`A therapeutic substance, such as a vaccine or
`drug, derived from biological sources.
`
`'an international biotechnology ｃｾｊｭｰ｡ｮｹ＠with
`interests In blologiads, agriculture, and
`phartn4ceuttcal products•
`
`More example sentences
`
`Pronunciation:
`
`biological J.bTe.lijek{a)ll
`
`11 words you perhaps didn't know
`were portmanteaus
`
`'Breech' or 'Bnlac:h'?
`
`Whktl of the following Is com!Ct?
`
`G Thertllar bAiedled lt8 banks
`
`0 Thertllar ｢ａｾｾｊ｣ｨ･､＠Its baflks
`
`Q/10
`
`TRENDING WORDS
`
`Most popular In tfle world
`
`1. BF
`
`2. translation
`
`3. Hindi
`
`4. bae
`
`5. supercalifragilisticexpialido
`cious
`
`DICTIONARY {US)
`
`biological
`
`MENU
`
`

`

`114f2017
`
`biological - d81irition r:l biological in ErQish I Oxbd Dictionaries
`
`Further reading
`
`5 tasty sandwich
`etymologies
`
`Which joe gave his name
`to 'sloppy joes7 We look at
`five interesting
`sandwiches and their
`lexical origins.
`
`READ MORE
`
`3 Signs You May Have Fatty Liver
`
`[Watch Now]
`
`6 punctuation marks
`you might be using
`incorrectly
`
`We take a look at several
`popular, though
`confusing, punctuation
`marks.
`
`READ MORE
`
`An A-Z of country
`name origins
`
`From Afghanistan to
`Zimbabwe, discover
`surprising and intriguing
`language facts from
`around the globe.
`
`READ MORE
`
`How brothers
`became buddies and
`bros
`
`The definitions of 'buddy'
`and 'bro' in the OED have
`recently been revised. We
`explore their history and
`increase in popularity.
`
`READ MORE
`
`What is the origin of
`'steal someone's
`thunder'?
`
`Susie Dent explores the
`surprisingly literal story
`behind the phrase 'to steal
`someone's thunder'.
`
`READ MORE
`
`DICTIONARY (US)
`
`biological
`
`gv Q
`
`ｾＺＱＯ･ｮＮｃﾻｃ｢Ｇ､｣｣｣ｴｩｯｮ｡ｲｩ･ｳＮ｣｣ｭｬ､･ｦｩｲｩｴｩｯｲｩｕｓＯ｜ｬｩ､ｯｧｩ｣｡ｬ＠
`
`MENU
`
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`biological - deli nition of biological in English 1 Oxford Dictionaries
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