From: Einstein, Matt
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`Sent: 7/28/2017 5:52:26 PM
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`To: TTAB EFiling
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`Subject: U.S. TRADEMARK APPLICATION NO. 86926766 - MORPHINE STRENGTH NON-ADDICTIVE -
`147535-00116 - Request for Reconsideration Denied - Return to TTAB - Message 5 of 8
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`Attachment Information:
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`Count: 9
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`Files: 7-6.jpg, 8-1.jpg, 8-2.jpg, 9-1.jpg, 9-2.jpg, 9-3.jpg, 9-4.jpg, 9-5.jpg, 9-6.jpg
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`nttp Ilwww mamaq comm-mnls/psirtmanaqementflmmini Emuleddiction tie none non addictive pain drugs are on
`lhe Way
`3755201? US W 15 PM
`
`“Ziconotide is the fl rst major pain killer approved by the FDA in the past 25 years.
`So, it’s taken 25 years to come up with something that is better than morphine." At
`least it’s better for certain patients, he notes. especially for those who no longer
`respond to morphine. “Zinomotide does not give you addiction because it works by a
`lumlly diffurnltucchnnistn. Basically, il‘s by mum] taunting, and all yum
`doing is blocking the transmission at a level that has nothing to do with addiction."
`Additionally, mating solutions targeted at a certaintypc ofrcceptor, protein, or other
`biological component, without adversely alfezting other biological components, is an
`issue, Hameed adds
`“There is always a difllculty inproducing receptor specific medications that do not
`nervous sysie'nt thec'nant'sins, since that would tnc'rease tlie rislt ot activating central
`dopamine systems and produce analgesic tolerance, he says. Hargreaves believes the
`“OLAM system satisfies at least some ofthese criteria."
`For Mari, the complex process ofaddiction is one ofthe main barriers in developing
`non-addictive pain drugs. “Opioid receptors are responsible in great part for all of
`these addiction problems." he says. “They are good pain killers, but only last very
`shortly; after a while, some people develop tolerance to tnorplnne= so they no longer
`get analgesia from it.“ The alternatives currently are slim, he says.
`"Ziconcnde is die fi rst major pain killer approved by the FDA in the past 25 years.
`So, it’s taken 25 yeat: in coins up With something that is better than morphine.“ At
`least it’s better for cmain patients= he notes, especially for those who no longer
`respond to morphine. “Inconotide does not give you addiction because it works by a
`totally diam“: mechanism. Bosicnl1y, it‘s by neuronal transmissian and all you’re
`doing is blocking the transmission at a level that has nothing to do with addiction.”
`Additionally. creating solutions targeted at a certain type ofreceptor, protein, or other
`biological component without adversely afiecting other biological components, is an
`issue, Hameed adds.
`“There is alwavs a difi'iculty in producing receptor specific medications that do not
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`“01AM system satisfies at least some afthese critcrt
`For Mari, the complex process ofadtlictiort rs one ofthe main barriers in developing
`non-addictive pain drugs. “Opioid receptors are responsible in great part for all at
`these addiction problems." he says. “They are good pain killers. but only last very
`shortly; sitar a while, some people develop tolerance to morphine= so they no longer
`get analgesia from it." The alternatives currently are slim. he says.
`“Zionnnrirla is the fi m major pain killer approved by the FDA in the past 25 years.
`So, it’s taken 25 years to come up With something that is better than morphine.“ At
`least it’s better for certain patients, he notes, especially for those who no longer
`respond to morphine. ‘Ziconntiile dues not give you addiction because it works by a
`totally difi'erent mechanism. Basically: it‘s by neuronal transmission, and all you’re
`doing is blocking the transmission at a level that has nothing to do with addiction."
`Additionally, creating solutions targeted at a certain type ofreceptor, protein, or other
`biological component without adversely afieeting other biological components, is an
`issue, Hameed adds.
`“There is always i. diflimlty in producing impair specific medications that do not
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`hm: Ilcmad mqlreseemhersrdeveloprnmnreddmlwermpmud/ EIWQSJ'ZDW 06 [IE 07 PM
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`mum wumensdmarehabmmorv-addwmwve-chr‘uniouam-treatmenfl
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`D7125I2017 06:06.27 PM
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`r... “may...”
`i destinationhope
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`hm: waw womensamorehah corn/non-addictive-chronic-Dein-treetrnenl/
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`0712512017 D6 06 27 PM
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`Non-Addictive Chronic Pain
`Treatment
`
`l-" emu-ei- :t-i
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`
`What 15 Chronic Pain?
`Pain is a natural sensation that is tnggered by your brain when you've been hurt in some way. The purpose
`of the pain response is to iet you know that you may have injured yourseit and need to take care Myourself
`We have all been in pain at one time or another. maybe from a fall, hum or sports injury. huttypicaity that
`pain level is short lived. In order For pain to be classified as chronic. it needs to be acute pain mat persists lor
`rnonms or even years. Common chronic pain compiaints include headache. low back pain. cancer pain.
`ennrnis pain. or pain that results nom nerve damage.
`
`Chronic Pain And Addiction
`Chronic pain Is often treated with opiate prescription pain medication. also known as painkillers While
`intended to be a short-term medical intervention. With chronic pain people often find themselves using the
`pain medications tor long periods of time and addiction is usually not far behind. This is because pain
`medication doesn't actually heal the pain or take it away. It simply masks it and the person gets high With an
`illusion that the pain is temporarily gone Over time. you need to take more plus to get the same result. so
`tolerance increases and the presence oi'withdrawai symptoms when you don‘t take the medication are
`inevitabie. The cycle Eton spirals and the addlcfion is born
`
`Non-Narcotic ('h rom't' Prr in Treatment
`At Destination Hope. we work with clients sutlering irom chronic pain by prowding a lot of fl‘ieiapy to help
`them cope with the emotions and life consequences that have manirestsd as a result or their pain. We aim
`work with heelthcare professionals that can oi'ler physical therapies and non-addictive medication options to
`chronic pain sufferers balding addiction. Painkillers affect the pleasure centers in the brain. nd eventually
`pain medication actauaiiy creates more pain as a result of increased toierance and withdrawal. Withdrawai
`symptoms can be quite painrul. making it dimcuit to datennine now much path a person is in as a result or a
`physical injury vs. withdrawal until they are detoxed appropriately and the pain medications are out afthelr
`system. After detox. we work with clients to assess their pain ieveis and ask scaling questions to eveiuale
`now debilitating their pain is or iltriey are sole to mnction at some ievei. From there. we utilize a combination
`of hon-narcotic approaches. These include massage. acupuncture. physical therapists. meditation. and
`chiropractors. Ollentirnes. people are looking tor a quick lie. and when you’re in pain that can mean taking a
`plti rather than putting the work in to heai or heip the Inlury recover. Non—narcotic physical medicai treatments
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`hm: 11W womeneamgreneb corn/nan-eddiehve-chmnic-Daln-treatmenl/
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`0712512017 DB 06 27 PM
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`with healthcare professionals can matte a big dinerence tn quality attire for chronic pain patients. but they
`have to be patient with the process and be willing to put in the walk toward their recevery There are else a
`variety nf medications that are nenadnict'we that can help relieve the symptnme associated with chronic.
`pain. The att'lertning we focus on with chronic pain patients is cognitive behavioral therapy which
`addresses the reality m‘ a person's situation in a therapeutic environment. Regardless of personal
`circumstances or eeciaecnnnmic etatuel we all have pain — emotional‘ physical or mental — it's a reality at life
`it‘s e matter ofleerning to realistically deal with it After the pain medications are out are person‘s system we
`start (a see the undenying angel. fiustratiun. and self pity came nut and we work with chants tu heip them
`address these feelings Living with chronic pain doesn't have to mean a llre plagued by adulation to
`painkiller: Call the ceuneeiers at Destination Hope The Women‘s Program ta learn more abeut our drug
`and alcohol rehabilitation programs at 1-966-808-7111 We are here to help yeu recover day or night.
`
`
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`REAO THE PREViOUS POST
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`RFAD THF NFXT POST
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`him:JW‘wumensdmarehabmmmon-addwmwve-chmnio-uawmreatmerw
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`D7f25I2017 06:06.27 PM
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`0712512017 0306.27 PM
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`U7f25l2017 0606 27' PM
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`hflDJ/WN wumsnsdruarehab common-addwchve-chrnnic-omn-treatmenv
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`mum“ aefina
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