`
`CURRICULUM VITAE
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`Adrian S. Dobs, MD MHS
`Curriculum Vitae – Page 1
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`Updated: 11 March 2024
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`ADRIAN SANDRA DOBS, MD MHS
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`
`
`CURRENT APPOINTMENTS
`
`Professor of Medicine and Oncology
`Division of Endocrinology, Diabetes and Metabolism
`
`Director, Johns Hopkins Clinical Research Network
`Johns Hopkins Institute for Clinical and Translational Research (ICTR)
`The Johns Hopkins University School of Medicine
`
`
`PERSONAL DATA
`
`Business Address
`Division of Endocrinology, Diabetes and Metabolism
`The Johns Hopkins University School of Medicine
`1830 E. Monument St, Suite 333
`Baltimore, MD 21287
`Tel.: 443.287-4000
`Fax
`410.955-8172
`e-mail: adobs@jhu.edu
`
`
`EDUCATION AND TRAINING
`1973
`BS
`Cornell University; Ithaca, NY
`1978
`MD
`Albany Medical College; Albany, NY
`Residency Albert Einstein College of Medicine; Montefiore
`Hospital; Bronx, NY
`Albert Einstein College of Medicine; Montefiore
`Hospital; Bronx, NY
`The Johns Hopkins University School of Medicine;
`Baltimore, MD
`The Johns Hopkins University School of Hygiene
`and Public Health; Baltimore, MD
`
`1978-1981
`
`1981-1982
`
`Chief
`Resident
`
`1982-1985
`
`Fellowship
`
`1990
`
`MHS
`
`Home Address
`3510 Anton Farms Road
`Baltimore, MD 21208
`Tel.: 410.653-3049
`
`Nutrition Sciences
`Medicine
`
`Internal Medicine
`
`Internal Medicine
`
`Endocrinology
`
`Cardiovascular Epidemiology
`
`
`
`PROFESSIONAL EXPERIENCE
`1985-1987
`Instructor, Division of Endocrinology and Metabolism; Department of Medicine; The Johns
`Hopkins University School of Medicine; Baltimore, MD
`
`SPRUCE – EXHIBIT 2015
`Neurocrine Biosciences, Inc. v. Spruce Biosciences, Inc.
`PGR2022-00025
`
`

`

`1993-2000
`
`1997-2002
`
`2000-2007
`
`2000-2015
`
`2010-2012
`
`
`
`1987-1993
`
`Adrian S. Dobs, MD MHS
`Curriculum Vitae – Page 2
`
`Assistant Professor of Medicine; The Johns Hopkins University School of Medicine; Baltimore,
`MD
`Associate Professor of Medicine; The Johns Hopkins University School of Medicine; Baltimore,
`MD
`Deputy Director for Clinical Research; Department of Medicine; The Johns Hopkins University
`School of Medicine
`Principal Investigator; Johns Hopkins Center for Complementary and Alternative Medicine in
`Cancer
`2000-present Professor of Medicine and Oncology; Johns Hopkins University School of Medicine; Baltimore,
`MD
`Vice Chair for Faculty Development; Department of Medicine; The Johns Hopkins University
`School of Medicine
`Program Director, Johns Hopkins Center for the Reduction of Cancer Disparities; The Johns
`Hopkins Cancer Center; The Johns Hopkins University School of Medicine
`2011-present Director; Johns Hopkins Clinical Research Network; Johns Hopkins Institute for Clinical and
`Translational Research (ICTR); The Johns Hopkins University School of Medicine
`Principal Investigator/Program Director, Johns Hopkins Center for the Reduction of Cancer
`Disparities; The Johns Hopkins Cancer Center; The Johns Hopkins University School of
`Medicine
`Director, Johns Hopkins- SunYet Sen (China) Collaboration in Clinical Research, Johns Hopkins
`International
`
`2012-2020
`
`2013-2016
`
`
`
`RESEARCH ACTIVITIES
`
`Publications
`
`Peer-Reviewed Scientific Articles
`Howard L, Dobs A, Chodos R, Chu R, Loludice T: A comparison of administering protein alone and
`1.
`protein plus glucose on nitrogen balance. Am J Clin Nutr 1978 Feb; 31 (2): 226-229. PMID: 623044.
`Dobs AS, Phillips JA 3rd: Diagnosis of human endocrine disorders using recombinant DNA techniques.
`Clin Endocrinol Metab 1985 Feb; 14 (1): 273-294. Review. PMID: 2990778.
`Dobs AS, Phillips JA 3rd, Mallonee RL, Saudek CD, Ney RL: Pedigree analysis of the 5' flanking region
`of the insulin gene in familial diabetes mellitus. Metabolism 1986 Jan; 35 (1): 13-17. PMID: 3001475.
`Dobs AS, Dempsey MA, Ladenson PW, Polk BF: Endocrine disorders in men infected with human
`immunodeficiency virus. Am J Med 1988 Mar; 84 (3 Pt 2): 611-616. PMID: 3348269.
`Dobs AS, Broussolle C, Lane MD: Regulation of insulin synthesis in an insulin-producing cell line
`(RINm5F): long-term experiments. In Vitro Cell Dev Biol 1989 Feb; 25 (2): 112-114. PMID: 2646270.
`Margolis S, Dobs AS: Nutritional management of plasma lipid disorders. J Am Coll Nutr 1989; 8
`Suppl: 33S-45S. Review. PMID: 2553790.
`Hunninghake DB, Knopp RH, Schonfeld G, Goldberg AC, Brown WV, Schaefer EJ, Margolis S, Dobs
`AS, Mellies MJ, Insull W Jr, Stein EA: Efficacy and safety of pravastatin in patients with primary
`hypercholesterolemia. I. A dose-response study. Atherosclerosis 1990 Nov; 85 (1): 81-89. PMID:
`2126437.
`Dobs AS, Levine MA, Margolis S: Effects of pravastatin, a new HMG-CoA reductase inhibitor, on
`vitamin D synthesis in man. Metabolism 1991 May; 40 (5): 524-528. PMID: 1902546.
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`Curriculum Vitae – Page 3
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`Dobs AS, Sarma PS, Guarnieri T, Griffith L: Testicular dysfunction with amiodarone use. J Am Coll
`Cardiol 1991 Nov 1; 18 (5): 1328-1332. PMID: 1918711.
`Dobs AS, Sarma PS, Wilder L: Lipid-lowering diets in patients taking pravastatin, a new HMG-CoA
`reductase inhibitor: compliance and adequacy. Am J Clin Nutr 1991 Oct; 54 (4): 696-700. PMID:
`1910254.
`11. Wand GS, Dobs AS: Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking
`alcoholics. J Clin Endocrinol Metab 1991 Jun; 72 (6): 1290-1295. PMID: 2026749.
`Dobs AS, Sarma PS, Schteingart D: Long-term endocrine function in hypercholesterolemic patients
`treated with pravastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Metabolism
`1993 Sep; 42 (9): 1146-1152. PMID: 8412767.
`13. Masters RB, Stillman FA, Becker DM, Margolis S, Dobs AS: The use of focus groups in the design of
`cholesterol education intervention programs. Am J Health Promot 1993 Nov-Dec; 8 (2): 95-97. PMID:
`10146822.
`Pravastatin Multicenter Study Group II (Dobs AS): Comparative efficacy and safety of pravastatin and
`cholestyramine alone and combined in patients with hypercholesterolemia. Pravastatin Multicenter
`Study Group II. Arch Intern Med 1993 Jun 14; 153 (11): 1321-1329. PMID: 8507122.
`Blevins LS Jr, Dobs AS, Wand GS: Naloxone-induced activation of the hypothalamic-pituitary-adrenal
`axis in suspected central adrenal insufficiency. Am J Med Sci 1994 Sep; 308 (3): 167-170. PMID:
`8074133.
`Dobs AS, Masters RB, Rajaram L, Stillman FA, Wilder LB, Margolis S, Becker DM: A comparison of
`education methods and their impact on behavioral change in patients with hyperlipidemia. Patient Educ
`Couns 1994 Oct; 24 (2): 157-164. PMID: 7746765.
`Herrington DM, Kim LS, Miller ME, Mitchell SE, Walford GD, Dobs AS: Visual and quantitative
`computerized assessment of disease severity on peripheral angiograms. J Vasc Interv Radiol 1994
`Jul-Aug; 5 (4): 595-602. PMID: 7949717.
`Dobs AS, Prasad M, Goldberg A, Guccione M, Hoover DR: Changes in serum lipoprotein(a) in
`hyperlipidemic subjects undergoing long-term treatment with lipid-lowering drugs. Cardiovasc Drugs
`Ther 1995 Oct; 9 (5): 677-684. PMID: 8573550.
`Arver S, Dobs AS, Meikle AW, Allen RP, Sanders SW, Mazer NA: Improvement of sexual function in
`testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal
`system. J Urol 1996 May; 155 (5): 1604-1608. PMID: 8627833.
`Dobs AS, Few WL 3rd, Blackman MR, Harman SM, Hoover DR, Graham NM: Serum hormones in men
`with human immunodeficiency virus-associated wasting. J Clin Endocrinol Metab 1996 Nov; 81 (11):
`4108-4112. PMID: 8923868.
`21. Meikle AW, Arver S, Dobs AS, Sanders SW, Rajaram L, Mazer NA: Pharmacokinetics and metabolism
`of a permeation-enhanced testosterone transdermal system in hypogonadal men: influence of
`application site- -a clinical research center study. J Clin Endocrinol Metab 1996 May; 81 (5): 1832-
`1840. PMID: 8626843.
`Arver S, Dobs AS, Meikle AW, Caramelli KE, Rajaram L, Sanders SW, Mazer NA: Long-term efficacy
`and safety of a permeation-enhanced testosterone transdermal system in hypogonadal men. Clin
`Endocrinol (Oxf) 1997 Dec; 47 (6): 727-737. PMID: 9497881.
`Cofrancesco J Jr, Whalen JJ 3rd, Dobs AS: Testosterone replacement treatment options for HIV-
`infected men. J Acquir Immune Defic Syndr Hum Retrovirol 1997 Dec 1; 16 (4): 254-265. PMID:
`9402072.
`Lehmann LS, Brancati FL, Chen MC, Roter D, Dobs AS: The effect of bedside case presentations on
`patients' perceptions of their medical care. N Engl J Med 1997 Apr 17; 336 (16): 1150-1155. PMID:
`9099660.
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`Curriculum Vitae – Page 4
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`25. Meikle AW, Arver S, Dobs AS, Adolfsson J, Sanders SW, Middleton RG, Stephenson RA, Hoover DR,
`Rajaram L, Mazer NA: Prostate size in hypogonadal men treated with a nonscrotal permeation-
`enhanced testosterone transdermal system. Urology 1997 Feb; 49 (2): 191-196. PMID: 9037280.
`Zheng ZJ, Sharrett AR, Chambless LE, Rosamond WD, Nieto FJ, Sheps DS, Dobs A, Evans GW,
`Heiss G: Associations of ankle-brachial index with clinical coronary heart disease, stroke and
`preclinical carotid and popliteal atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Study.
`Atherosclerosis 1997 May; 131 (1): 115-125. PMID: 9180252.
`Dobs AS: Androgen therapy in AIDS wasting. Baillieres Clin Endocrinol Metab 1998 Oct; 12 (3): 379-
`390. PMID: 10332560.
`Dobs AS, El-Deiry S, Wand G, Wiederkehr M: Central hypogonadism: distinguishing idiopathic low
`testosterone from pituitary tumors. Endocr Pract 1998 Nov-Dec; 4 (6): 355-359. PMID: 15251707.
`Dobs AS, Hoover DR, Chen MC, Allen R: Pharmacokinetic characteristics, efficacy, and safety of
`buccal testosterone in hypogonadal males: a pilot study. J Clin Endocrinol Metab 1998 Jan; 83 (1): 33-
`39. PMID: 9435413.
`Laube BL, Benedict GW, Dobs AS: The lung as an alternative route of delivery for insulin in controlling
`postprandial glucose levels in patients with diabetes. Chest 1998 Dec; 114 (6): 1734-1739. PMID:
`9872209.
`Laube BL, Benedict GW, Dobs AS: Time to peak insulin level, relative bioavailability, and effect of site
`of deposition of nebulized insulin in patients with noninsulin-dependent diabetes mellitus. J Aerosol
`Med 1998 Fall; 11 (3): 153-173. PMID: 10186961.
`32. Meikle AW, Dobs AS, Arver S, Caramelli KE, Sanders SW, Mazer NA: Androgen replacement in the
`treatment of Klinefelter's syndrome: efficacy and safety of a nonscrotal permeation-enhanced
`testosterone transdermal system. Endocr Pract 1998 Jan-Feb; 4 (1): 17-22. PMID: 15251759.
`33. Miller LR, Partin AW, Chan DW, Bruzek DJ, Dobs AS, Epstein JI, Walsh PC: Influence of radical
`prostatectomy on serum hormone levels. J Urol 1998 Aug; 160 (2): 449-453. PMID: 9679896.
`Stein EA, Davidson MH, Dobs AS, Schrott H, Dujovne CA, Bays H, Weiss SR, Melino MR,
`Stepanavage ME, Mitchel YB: Efficacy and safety of simvastatin 80 mg/day in hypercholesterolemic
`patients. The Expanded Dose Simvastatin US Study Group. Am J Cardiol 1998 Aug 1; 82 (3): 311-
`316. PMID: 9708659.
`Barzilay JI, Spiekerman CF, Wahl PW, Kuller LH, Cushman M, Furberg CD, Dobs A, Polak JF, Savage
`PJ: Cardiovascular disease in older adults with glucose disorders: comparison of American Diabetes
`Association criteria for diabetes mellitus with WHO criteria. Lancet 1999 Aug 21; 354 (9179): 622-625.
`PMID: 10466662.
`Basaria S, Dobs AS: Risks versus benefits of testosterone therapy in elderly men. Drugs Aging 1999
`Aug; 15 (2): 131-142. PMID: 10495072.
`Cushman M, Meilahn EN, Psaty BM, Kuller LH, Dobs AS, Tracy RP: Hormone replacement therapy,
`inflammation, and hemostasis in elderly women. Arterioscler Thromb Vasc Biol 1999 Apr; 19 (4): 893-
`899. PMID: 10195915.
`Dobs AS: Is there a role for androgenic anabolic steroids in medical practice? JAMA 1999 Apr 14; 281
`(14): 1326-1327. PMID: 10208149.
`Dobs AS, Cofrancesco J Jr, Nolten WE, Danoff A, Anderson R, Hamilton CD, Feinberg J, Seekins D,
`Yangco B, Rhame F: The use of a transscrotal testosterone delivery system in the treatment of
`patients with weight loss related to human immunodeficiency virus infection. Am J Med 1999 Aug; 107
`(2): 126-132. PMID: 10460042.
`Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA: Pharmacokinetics, efficacy,
`and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly
`injections of testosterone enanthate for the treatment of hypogonadal men. J Clin Endocrinol Metab
`1999 Oct; 84 (10): 3469-3478. PMID: 10522982.
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`Dobs AS, Nieto FJ, Szklo M, Barnes R, Sharrett AR, Ko WJ: Risk factors for popliteal and carotid wall
`thicknesses in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 1999 Nov 15;
`150 (10): 1055-1067. PMID: 10568620.
`Schoen RE, Tangen CM, Kuller LH, Burke GL, Cushman M, Tracy RP, Dobs A, Savage PJ: Increased
`blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst 1999 Jul 7; 91
`(13): 1147-1154. PMID: 10393723.
`Smith NL, Heckbert SR, Bittner VA, Savage PJ, Barzilay JI, Dobs AS, Psaty BM: Antidiabetic
`treatment trends in a cohort of elderly people with diabetes The cardiovascular health study, 1989-
`1997. Diabetes Care 1999 May; 22 (5): 736-742. PMID: 10332674.
`44. Wisniewski AB, Nguyen TT, Flannery TW, Dobs AS: Hypogonadal status and functional cerebral
`lateralization in adult men. Brain Cognition 1999; 40 (1): 276-281.
`Ariyo AA, Haan M, Tangen CM, Rutledge JC, Cushman M, Dobs A, Furberg CD: Depressive
`symptoms and risks of coronary heart disease and mortality in elderly Americans. Cardiovascular
`Health Study Collaborative Research Group. Circulation 2000 Oct 10; 102 (15): 1773-1779. PMID:
`11023931.
`Basaria S, Ayala AR, Guerin C, Dobs AS: A rare pituitary lesion. J Endocrinol Invest 2000 Mar; 23 (3):
`189-192. PMID: 10803478.
`Basaria S, Dobs AS: Treatment of hyperlipidemia in women. Int J Fertil Womens Med 2000 Jan-Feb;
`45 (1): 22-33. PMID: 10721741.
`Dobs AS, Miller S, Neri G, Weiss S, Tate AC, Shapiro DR, Musliner TA: Effects of simvastatin and
`pravastatin on gonadal function in male hypercholesterolemic patients. Metabolism 2000 Jan; 49 (1):
`115-121. PMID: 10647074.
`Dobs AS, Schrott H, Davidson MH, Bays H, Stein EA, Kush D, Wu M, Mitchel Y, Illingworth RD:
`Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with
`hypercholesterolemia. Metabolism 2000 Sep; 49 (9): 1234-1238. PMID: 11016911.
`Recto CS 2nd, Acosta S, Dobs A: Comparison of the efficacy and tolerability of simvastatin and
`atorvastatin in the treatment of hypercholesterolemia. Clin Cardiol 2000 Sep; 23 (9): 682-688. PMID:
`11016019.
`Swerdloff RS, Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T,
`Longstreth J, Berman N: Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal
`men. J Clin Endocrinol Metab 2000 Dec; 85 (12): 4500-4510. PMID: 11134099.
`52. Wahlstrom JT, Dobs AS: Acute and long-term effects of AIDS and injection drug use on gonadal
`function. J Acquir Immune Defic Syndr 2000 Oct 1; 25 Suppl 1: S27-36. PMID: 11126423.
`53. Wahlstrom JT, Tang A, Cofrancesco J Jr, Shah N Jr, Dobs AS: Gonadal hormone levels in injection
`drug users. Drug Alcohol Depend 2000 Nov 1; 60 (3): 311-313. PMID: 11053766.
`54. Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, Matsumoto AM, Weber T,
`Berman N; Testosterone Gel Study Group: Transdermal testosterone gel improves sexual function,
`mood, muscle strength, and body composition parameters in hypogonadal men. J Clin Endocrinol
`Metab 2000 Aug; 85 (8): 2839-2853. PMID: 10946892.
`Basaria S, Dobs AS: Hypogonadism and androgen replacement therapy in elderly men. Am J Med
`2001 May; 110 (7): 563-572. PMID: 11343670.
`Basaria S, Wahlstrom JT, Dobs AS: Clinical review 138: Anabolic-androgenic steroid therapy in the
`treatment of chronic diseases. J Clin Endocrinol Metab 2001 Nov; 86 (11): 5108-5117. PMID:
`11701661.
`Cushman M, Psaty BM, Meilahn EN, Dobs AS, Kuller LH: Post-menopausal hormone therapy and
`concentrations of protein C and antithrombin in elderly women. Br J Haematol 2001 Jul; 114 (1): 162-
`168. PMID: 11472362.
`Dobs AS, Bachorik PS, Arver S, Meikle AW, Sanders SW, Caramelli KE, Mazer NA: Interrelationships
`among lipoprotein levels, sex hormones, anthropometric parameters, and age in hypogonadal men
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`treated for 1 year with a permeation-enhanced testosterone transdermal system. J Clin Endocrinol
`Metab 2001 Mar; 86 (3): 1026-1033. PMID: 11238481.
`59. Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, Matsumoto AM, Weber T,
`Berman N: Effects of transdermal testosterone gel on bone turnover markers and bone mineral density
`in hypogonadal men. Clin Endocrinol (Oxf) 2001 Jun; 54 (6): 739-750. PMID: 11422108.
`Basaria S, Lieb J 2nd, Tang AM, DeWeese T, Carducci M, Eisenberger M, Dobs AS: Long-term effects
`of androgen deprivation therapy in prostate cancer patients. Clin Endocrinol (Oxf) 2002 Jun; 56 (6):
`779-786. PMID: 12072048.
`Basaria S, Nguyen T, Rosenson RS, Dobs AS: Effect of methyl testosterone administration on plasma
`viscosity in postmenopausal women. Clin Endocrinol (Oxf) 2002 Aug; 57 (2): 209-214. PMID:
`12153599.
`Brown TT, Dobs AS: Endocrine effects of marijuana. J Clin Pharmacol 2002 Nov; 42 (11 Suppl): 90S-
`96S. PMID: 12412841.
`Dobs A, Brown T: Metabolic abnormalities in HIV disease and injection drug use. J Acquir Immune
`Defic Syndr. 2002 Oct 1; 31 Suppl 2:S70-7. Review. PMID: 12394785.
`Dobs A, Brown T: Metabolic abnormalities in HIV disease and injection drug use. J Acquir Immune
`Defic Syndr 2002; 31 (Suppl 2): S70-77. PMID: 12394785
`Dobs AS, Nguyen T, Pace C, Roberts CP: Differential effects of oral estrogen versus oral estrogen-
`androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol
`Metab 2002 Apr; 87 (4): 1509-1516. PMID: 11932273.
`Schwetz BA, Dobs AS: Streamlining the clinical research enterprise. J Investig Med 2002 Sep; 50 (5):
`356-360. PMID: 12227660.
`Smit E, Skolasky RL, Dobs AS, Calhoun BC, Visscher BR, Palella FJ, Jacobson LP: Changes in the
`incidence and predictors of wasting syndrome related to human immunodeficiency virus infection,
`1987-1999. Am J Epidemiol 2002 Aug 1; 156 (3): 211-218. PMID: 12142255.
`68. Wisniewski AB, Nguyen TT, Dobs AS: Evaluation of high-dose estrogen and high-dose estrogen plus
`methyltestosterone treatment on cognitive task performance in postmenopausal women. Horm Res
`2002; 58 (3): 150-155. PMID: 12218381.
`Basaria S, Dobs A: Andropause: to treat or not to treat? J Endocrinol Invest 2003 Jul; 26 (7): 693-697.
`PMID: 14594126.
`Basaria S, Dobs AS: New modalities of transdermal testosterone replacement. Treat Endocrinol 2003;
`2 (1): 1-9. PMID: 15871550.
`Bravin RE, Wisniewski AB, Dobs AS: Soy and Cognition. Elements 2003; 1 (2): 12-14.
`Brown TT, Zelnik DL, Dobs AS: Fish oil supplementation in the treatment of cachexia in pancreatic
`cancer patients. Int J Gastrointest Cancer 2003; 34 (2-3): 143-150. PMID: 15361649.
`Cooper OB, Brown TT, Dobs AS: Opiate drug use: a potential contributor to the endocrine and
`metabolic complications in human immunodeficiency virus disease. Clin Infect Dis 2003; 37 Suppl 2:
`S132-136. PMID: 12942387.
`Dobs A: Role of testosterone in maintaining lean body mass and bone density in HIV-infected patients.
`Int J Impot Res 2003 Aug; 15 Suppl 4: S21-25. PMID: 12934047.
`Genel M, Dobs A: Translating clinical research into practice: practice-based research networks--a
`promising solution. J Investig Med 2003 Mar; 51 (2): 64-71. Review. PMID: 12643510.
`Isaacsohn J, Hunninghake D, Schrott H, Dujovne CA, Knopp R, Weiss SR, Bays H, Crouse JR 3rd,
`Davidson MH, Keilson LM, McKenney J, Korenman SG, Dobs AS, Stein E, Krauss RM, Maccubbin D,
`Cho M, Plotkin DJ, Mitchel YB: Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with
`hypertriglyceridemia. Clin Cardiol 2003 Jan; 26 (1): 18-24. PMID: 12539808.
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`77. Moore E, Wisniewski A, Dobs A: Endocrine treatment of transsexual people: a review of treatment
`regimens, outcomes, and adverse effects. J Clin Endocrinol Metab 2003 Aug; 88 (8): 3467-3473.
`PMID: 12915619.
`Ojumu A, Dobs AS: Is hypogonadism a risk factor for sexual dysfunction? J Androl 2003 Nov-Dec; 24
`(6 Suppl): S46-51. PMID: 14581495.
`Riddler SA, Smit E, Cole SR, Li R, Chmiel JS, Dobs A, Palella F, Visscher B, Evans R, Kingsley LA:
`Impact of HIV infection and HAART on serum lipids in men. JAMA 2003 Jun 11; 289 (22): 2978-2982.
`PMID: 12799406.
`Simpson JL, de la Cruz F, Swerdloff RS, Samango-Sprouse C, Skakkebaek NE, Graham JM Jr,
`Hassold T, Aylstock M, Meyer-Bahlburg HF, Willard HF, Hall JG, Salameh W, Boone K, Staessen C,
`Geschwind D, Giedd J, Dobs AS, Rogol A, Brinton B, Paulsen CA: Klinefelter syndrome: expanding
`the phenotype and identifying new research directions. Genet Med 2003 Nov-Dec; 5 (6): 460-468.
`PMID: 14614399.
`Sung NS, Crowley WF Jr, Genel M, Salber P, Sandy L, Sherwood LM, Johnson SB, Catanese V, Tilson
`H, Getz K, Larson EL, Scheinberg D, Reece EA, Slavkin H, Dobs A, Grebb J, Martinez RA, Korn A,
`Rimoin D. Central challenges facing the national clinical research enterprise. JAMA 2003 Mar 12; 289
`(10): 1278-1287. PMID: 12633190.
`Basaria S, Dobs AS: Safety and adverse effects of androgens: how to counsel patients. Mayo Clin
`Proc 2004 Apr; 79 (4 Suppl): S25-32. PMID: 15065635.
`Block KI, Burns B, Cohen AJ, Dobs AS, Hess SM, Vickers A: Point-counterpoint: using clinical trials
`for the evaluation of integrative cancer therapies. Integr Cancer Ther 2004 Mar; 3 (1): 66-81. PMID:
`15035878.
`Block KI, Cohen AJ, Dobs AS, Ornish D, Tripathy D: The challenges of randomized trials in integrative
`cancer care. Integr Cancer Ther 2004 Jun; 3 (2): 112-127. PMID: 15165498.
`Brown TT, Ruppe MD, Kassner R, Kumar P, Kehoe T, Dobs AS, Timpone J: Reduced bone mineral
`density in human immunodeficiency virus-infected patients and its association with increased central
`adiposity and postload hyperglycemia. J Clin Endocrinol Metab 2004 Mar; 89 (3): 1200-1206. PMID:
`15001610.
`Crowley WF Jr, Sherwood L, Salber P, Scheinberg D, Slavkin H, Tilson H, Reece EA, Catanese V,
`Johnson SB, Dobs A, Genel M, Korn A, Reame N, Bonow R, Grebb J, Rimoin D: Clinical research in
`the United States at a crossroads: proposal for a novel public-private partnership to establish a national
`clinical research enterprise. JAMA 2004 Mar 3; 291 (9): 1120-1126. PMID: 14996782.
`Dobs AS, Matsumoto AM, Wang C, Kipnes MS: Short-term pharmacokinetic comparison of a novel
`testosterone buccal system and a testosterone gel in testosterone deficient men. Curr Med Res Opin
`2004 May; 20 (5): 729-738. PMID: 15140340.
`Dupree K, Dobs A: Osteopenia and male hypogonadism. Rev Urol 2004; 6 Suppl 6: S30-34. PMID:
`16985910; PMCID: PMC1472878.
`Golden SH, Ding J, Szklo M, Schmidt MI, Duncan BB, Dobs A: Glucose and insulin components of the
`metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the
`atherosclerosis risk in communities study. Am J Epidemiol 2004 Sep 15; 160 (6): 540-548. PMID:
`15353414.
`Golub ET, Latka M, Hagan H, Havens JR, Hudson SM, Kapadia F, Campbell JV, Garfein RS, Thomas
`DL, Strathdee SA, The STRIVE Project (Dobs AS): Screening for depression symptoms among HCV-
`infected injection drug users: examination of the utility of the CES-D and the Beck Depression
`Inventory. J Urban Health 2004; 81 (2): 278-290. PMID: 15136661
`91. Manolio TA, Cushman M, Gottdiener JS, Dobs A, Kuller LH, Kronmal RA, CHS Collaborative Research
`Group: Predictors of falling cholesterol levels in older adults: the Cardiovascular Health Study. Ann
`Epidemiol 2004 May; 14 (5): 325-331. PMID: 15177271.
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`83.
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`92. Miller M, Dobs A, Yuan Z, Battisti WP, Borisute H, Palmisano J: Effectiveness of simvastatin therapy
`in raising HDL-C in patients with type 2 diabetes and low HDL-C. Curr Med Res Opin 2004 Jul; 20 (7):
`1087-1094. PMID: 15265253.
`93. Mudali S, Dobs AS: Effects of testosterone on body composition of the aging male. Mech Ageing Dev
`2004 Apr; 125 (4): 297-304. PMID: 15063106.
`Palella FJ Jr, Cole SR, Chmiel JS, Riddler SA, Visscher B, Dobs A, Williams C: Anthropometrics and
`examiner-reported body habitus abnormalities in the multicenter AIDS cohort study. Clin Infect Dis
`2004 Mar 15; 38 (6): 903-907. PMID: 14999638.
`95. Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Berman N,
`Hull L, Swerdloff RS: Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on
`sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin
`Endocrinol Metab 2004 May; 89 (5): 2085-2098. PMID: 15126525.
`96. Wang C, Swerdloff R, Kipnes M, Matsumoto AM, Dobs AS, Cunningham G, Katznelson L, Weber TJ,
`Friedman TC, Snyder P, Levine HL: New testosterone buccal system (Striant) delivers physiological
`testosterone levels: pharmacokinetics study in hypogonadal men. J Clin Endocrinol Metab 2004 Aug;
`89 (8): 3821-3829. PMID: 15292312.
`Brown TT, Cole SR, Li X, Kingsley LA, Palella FJ, Riddler SA, Visscher BR, Margolick JB, Dobs AS:
`Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS
`cohort study. Arch Intern Med 2005 May 23; 165 (10): 1179-1184. PMID: 15911733.
`Brown TT, Li X, Cole SR, Kingsley LA, Palella FJ, Riddler SA, Chmiel JS, Visscher BR, Margolick JB,
`Dobs AS: Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated
`with insulin resistance markers in the Multicenter AIDS Cohort Study. AIDS 2005 Sep 2; 19 (13): 1375-
`1383. PMID: 16103768.
`Dobs A, Darkes MJ: Incidence and management of gynecomastia in men treated for prostate cancer.
`J Urol 2005 Nov; 174 (5): 1737-1742. PMID: 16217274.
`100. Harle L, Basaria S, Dobs AS: Nebido: a long-acting injectable testosterone for the treatment of male
`hypogonadism. Expert Opin Pharmacother 2005 Aug; 6 (10): 1751-1759. PMID: 16086661.
`101. Harle L, Brown T, Laheru D, Dobs AS: Omega-3 fatty acids for the treatment of cancer cachexia:
`issues in designing clinical trials of dietary supplements. J Altern Complement Med 2005 Dec; 11 (6):
`1039-1046. PMID: 16398596.
`102. Karmon SL, Moore RD, Dobs AS, Keruly J, Barnett S, Cofrancesco J Jr: Body shape and composition
`in HIV-infected women: an urban cohort. HIV Med 2005 Jul; 6 (4): 245-252. PMID: 16011529.
`103. Klein RS, Lo Y, Santoro N, Dobs AS: Androgen levels in older men who have or who are at risk of
`acquiring HIV infection. Clin Infect Dis 2005 Dec 15; 41 (12): 1794-1803. PMID: 16288406; PMCID:
`PMC2426822.
`104. Kupersmith J, Sung N, Genel M, Slavkin H, Califf R, Bonow R, Sherwood L, Reame N, Catanese V,
`Baase C, Feussner J, Dobs A, Tilson H, Reece EA: Creating a new structure for research on health
`care effectiveness. J Investig Med 2005 Mar; 53 (2): 67-72. PMID: 15810492.
`105. Mudali S, Dobs AS, Ding J, Cauley JA, Szklo M, Golden SH, atherosclerosis risk in communities study:
`Endogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities
`study. J Clin Endocrinol Metab 2005 Feb; 90 (2): 1202-1209. PMID: 15546905.
`106. Wisniewski AB, Apel S, Selnes OA, Nath A, McArthur JC, Dobs AS: Depressive symptoms, quality of
`life, and neuropsychological performance in HIV/AIDS: the impact of gender and injection drug use. J
`Neurovirol 2005 Apr; 11 (2): 138-143. PMID: 16036792.
`107. Wisniewski AB, Prendeville MT, Dobs AS: Handedness, functional cerebral hemispheric lateralization,
`and cognition in male-to-female transsexuals receiving cross-sex hormone treatment. Arch Sex Behav
`2005 Apr; 34 (2): 167-172. PMID: 15803250.
`108. Basaria S, Dobs AS: Clinical review: Controversies regarding transdermal androgen therapy in
`postmenopausal women. J Clin Endocrinol Metab 2006 Dec; 91 (12): 4743-452. PMID: 16984993.
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`109. Basaria S, Muller DC, Carducci MA, Egan J, Dobs AS: Hyperglycemia and insulin resistance in men
`with prostate carcinoma who receive androgen-deprivation therapy. Cancer 2006 Feb 1; 106 (3): 581-
`588. PMID: 16388523.
`110. Braga-Basaria M, Dobs AS, Muller DC, Carducci MA, John M, Egan J, Basaria S: Metabolic syndrome
`in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol 2006
`Aug 20; 24 (24): 3979-3983. PMID: 16921050.
`111. Braga-Basaria M, Muller DC, Carducci MA, Dobs AS, Basaria S: Lipoprotein profile in men with
`prostate cancer undergoing androgen deprivation therapy. Int J Impot Res 2006 Sep-Oct; 18 (5): 494-
`498. PMID: 16617314.
`112. Brown T, Wang Z, Chu H, Palella FJ, Kingsley L, Witt MD, Dobs AS: Longitudinal anthropometric
`changes in HIV-infected and HIV-uninfected men. J Acquir Immune Defic Syndr 2006 Nov 1; 43 (3):
`356-362. PMID: 16980910.
`113. Brown TT, Wisniewski AB, Dobs AS: Gonadal and Adrenal Abnormalities in Drug Users: Cause or
`Consequence of Drug Use Behavior and Poor Health Outcomes. Am J Infect Dis 2006; 2 (3): 130-135.
`PMID: 17364020; PMCID: PMC1821355.
`114. Campbell JV, Hagan H, Latka MH, Garfein RS, Golub ET, Coady MH, Thomas DL, Strathdee SA; The
`STRIVE Project (Dobs AS): High prevalence of alcohol use among hepatitis C virus antibody positive
`injection drug users in three US cities. Drug Alcohol Depend 2006; 28; 81 (3): 259-265. PMID:
`16129567
`115. Cho M, Ye X, Dobs A, Cofrancesco J Jr: Prevalence of complementary and alternative medicine use
`among HIV patients for perceived lipodystrophy. J Altern Complement Med 2006 Jun; 12 (5): 475-482.
`PMID: 16813512.
`116. Cofrancesco J Jr, Shah N, Ghanem KG, Dobs AS, Klein RS, Mayer K, Schuman P, Vlahov D,
`Rompalo AM: The effects of illicit drug use and HIV infection on sex hormone levels in women.
`Gynecol Endocrinol 2006 May; 22 (5): 244-251. PMID: 16785144.
`117. Dobs A: Testosterone Deficiency and Supplementation in Chronic Disease States. Med Clin North
`Am 2006; 90 (S1): 14–18.
`118. Edelstein D, Dobs A, Basaria S: Emerging drugs for hypogonadism. Expert Opin Emerg Drugs 2006
`Nov; 11 (4): 685-707. PMID: 17064226.
`119. Grunfeld C, Kotler DP, Dobs A, Glesby M, Bhasin S: Oxandrolone in the treatment of HIV-associated
`weight loss in men: a randomized, double-blind, placebo-controlled study. J Acquir Immune Defic
`Syndr 2006 Mar; 41 (3): 304-314. PMID: 16540931.
`120. Khalsa JH, Vocci F, Dobs A: Hormonal and Metabolic Disorders of Human Immunodeficiency Virus
`Infection and Substance Abuse. Am J Infect Dis 2006; 2 (3): 125-129. PMID: 17676172; PMCID:
`PMC1939802.
`121. Maggio M, Blackford A, Taub D, Carducci M, Ble A, Metter EJ, Braga-Basaria M, Dobs A, Basaria S:
`Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen
`deprivation therapy. J Androl 2006 Nov-Dec; 27 (6): 725-728. PMID: 16775253.
`122. Miller M, Dobs A, Yuan Z, Battisti WP, Palmisano J: The effect of simvastatin on triglyceride-rich
`lipoproteins in patients with type 2 diabetic dyslipidemia: a SILHOUETTE trial sub-study. Curr Med Res
`Opin 2006 Feb; 22 (2): 343-350. PMID: 16466606.
`123. Palella FJ Jr, Chmiel JS, Riddler SA, Calhoun B, Dobs A, Visscher B, Kingsley L: A novel pattern of
`lipoaccumulation in HIV-infected men. JAMA 2006 Aug 16; 296 (7): 766-768. PMID: 16905782.
`124. Tien PC, Benson C, Zolopa AR, Sidney S., Osmond D, Grunfeld C, FRAM Investigators (Dobs AS):
`The Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM): Methods, Design and
`Sample Characteristics. Am J Epidemiol 2006; 163 (9): 860-869. PMID: 16524955
`125. Wisniewski AB, Brown TT, John M, Cofrancesco J Jr, Golub ET, Ricketts EP, Wand G, Dobs AS:
`Cortisol levels and depression in men and women using heroin and cocaine.
`Psychoneur