(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
`
`(19) World Intellectual Property
`Organization
`International Bureau
`
`I lllll llllllll II llllll lllll lllll lllll llll I II Ill lllll lllll lllll 111111111111111111111111111111111
`
`( 43) International Publication Date
`14 July 2005 (14.07.2005)
`
`PCT
`
`(10) International Publication Number
`WO 2005/062713 A2
`
`(51) International Patent Classification:
`
`Not classified
`
`(21) International Application Number:
`PCT/IL2004/001179
`
`(22) International Filing Date:
`29 December 2004 (29.12.2004)
`
`(25) Filing Language:
`
`(26) Publication Language:
`
`English
`
`English
`
`(30) Priority Data:
`60/533,709
`
`31December2003 (31.12.2003) US
`
`(71) Applicant and
`(72) Inventor: SHEVACH, Yosi [IL/IL]; 19, Brachia st., 61191
`Tel Aviv (IL).
`
`(74) Agent: GOLD - PATENTS & FINANCIAL SERVICES
`LTD.; 43, Rubinstein st., 34987 Haifa (IL).
`
`AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN,
`CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, Fl,
`GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE,
`KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD,
`MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG,
`PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM,
`TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM,
`zw.
`
`(84) Designated States (unless otherwise indicated, for every
`kind of regional protection available): ARIPO (BW, GH,
`GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM,
`ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM),
`European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl,
`FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO,
`SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN,
`GQ, GW, ML, MR, NE, SN, TD, TG).
`
`Published:
`without international search report and to be republished
`upon receipt of that report
`
`(81) Designated States (unless otherwise indicated, for every
`kind of national protection available): AE, AG, AL, AM,
`
`For two-letter codes and other abbreviations, refer to the "Guid(cid:173)
`ance Notes on Codes and Abbreviations" appearing at the begin(cid:173)
`ning of each regular issue of the PCT Gazette.
`
`-iiiiiiiiiiii
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`!!!!!!!! -
`
`iiiiiiiiiiii ----iiiiiiiiiiii
`iiiiiiiiiiii ----
`
`~
`,....i
`r-....
`M
`\0
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`..........
`lf) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
`
`g (54) Title: BETA VULGARIS-BASED PRODUCTS
`M
`0 (57) Abstract: Products based on beta vulgaris and especially red beet and methods for producing the same are provided. The orally
`> administered beta vulgaris based products are adapted to be used for reducing homocystein levels as well as reducing the cholesterol
`
`~ levels in the blood among other therapeutic effects.
`
`Human Power of N Company
`EX1027
`Page 1 of 17
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`WO 2005/062713
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`PCT/IL2004/001179
`
`BETA VULGARIS - BASED PRODUCTS
`
`FIELD OF THE INVENTION
`
`5
`
`10
`
`The present invention relates to products based on beta vulgaris. More
`
`particularly, the present invention relates to products such as beverages,
`
`juices, seasonings, vinegar, or delicacies based especially on red beet, as
`
`well as products for external use.
`
`BACKGROUND OF THE INVENTION
`
`Beta vulgaris and especially red beet had been shown to contain
`
`15
`
`substances such as folic acid, betain, and vitamin B6 that facilitate in
`
`balancing the levels of homocystein in the blood. Reducing and normalization
`
`of the homocystein levels by those three substances was shown by
`Lalouschek et al. in 1996 and Sella & Dolman in 1999. Red beet had been
`
`also used as treatment for high blood pressure (Krispil 2000) and had been
`
`20
`
`shown to reduce the blood pressure and the LDL cholesterol levels in the
`
`blood of patients treated with a sugar beet fiber reach diet (Hagander et al.,
`
`1989). Red beet had been shown also to act as an antioxidant (Kahkonen et
`
`al. 1999; Kujala et al. 2000) and had been ranked as one of the 10 leading
`
`vegetables having antioxidation effect (Kujala et al. 2000).
`
`25
`
`Another component that has been shown to be in substantial amounts
`
`relative to other vegetables are phytostrols. Phytostrols from a vegetable
`
`source had been shown by Jones et al. to reduce the cholesterol level in the
`
`blood.
`Red beet contains also fibers that had been shown to increase the
`
`30
`
`activity of Glutathion peroxidase in the liver of rats. In rats fed with a diet
`
`containing 15% isolated fibers of red beet, the activity of the enzyme was
`
`Page 2 of 17
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`WO 2005/062713
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`PCT/IL2004/001179
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`2
`
`increased (Bobek et al. 2000) wherein the enzyme is known for its antioxidant
`
`activity in cells and membranes (Shils et al.).
`
`Beta vulgaris and especially red beet was provided also as supportive
`
`treatment in liver diseases and in fatty liver by PDR in 1999 and Weiss in
`1988.
`
`5
`
`It should be emphasized that other components having therapeutic effect
`were found to be present in red beet. ·
`
`The effects shown herein are attributed to the natural compositions of the
`
`substances in the red beet root or leaves and red beet has to be consumes as
`
`10
`
`natural as possible in order to utilize its components in order to reduce the
`
`cholesterol and the homocysteine levels in the blood as well as to improve
`
`liver functionality. However, red beet is a vegetable that is hard to process to
`
`an edible form without fully or partially eliminating the active components.
`
`Moreover, red beet has a taste that is not favorable by many populations.
`
`15
`
`Therefore, has to be processed in an alternative manner so as to become
`
`favorable to populations that are not familiar with the taste of red beet or are
`
`not used to consume red beet.
`
`20
`
`SUMMARY OF THE INVENTION
`
`It is an object of the present invention to provide edible and non edible
`
`products that are based on beta vulgaris containing components having
`
`antioxidant effect among other therapeutic effects, and methods to produce
`
`25
`
`the same.
`
`It is another object of the present invention to provide alcoholic and non(cid:173)
`
`alcoholic beverages that are based on beta vulgaris, and methods to produce
`
`the same.
`It is yet another object of the present invention to provide products based
`
`30
`
`on red beet that are provided with other additives based on other herbs as
`
`well as sweeteners, food supplements etc. that can be used as well, so as to
`
`improve the effect of the products in the body.
`
`Page 3 of 17
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`PCT/IL2004/001179
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`3
`
`In addition, it is an object of the present invention to provide beta
`
`voulgaris and especially red beet-based products in the form of beverages or
`
`paste that can be provided as food supplements.
`
`It is therefore provided in accordance with a preferred embodiment of the
`
`5
`
`present invention a method of reducing homocystein levels as well as
`
`reducing the cholesterol levels in the blood among other therapeutic effects by
`orally administering a subject with beta vulgaris-based composition prepared
`
`by a process comprising:
`
`10
`
`preparing juice from beta vulgaris root;
`
`adding sweetening agent;
`
`filtering the resulting juice,
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, the process further comprising fermenting the mixture.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`15
`
`present invention,the process further comprising adding carbon dioxide.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present
`
`invention,
`
`the process
`
`further comprising adding yeasts and
`
`fermenting the resulting juice.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`20
`
`present invention, said beta vulgaris root is pilled.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, said beta vulgaris is red beet.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, said sweetening agent is selected from a group comprising
`
`25
`
`fruit extract (preferably apple extract), beet molasses, sugar cane molasses,
`
`honey, maltose, brown or white sugar, sweet pomegranate extract,
`
`oligofructose, oligosaccharides.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, the process further comprising fermenting the resulting
`
`30
`
`juice; allowing natual acidation; filtering the juice; and adding bacteria so as to
`
`produce vinegar or seasoning.
`
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`PCT/IL2004/001179
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`4
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, the process further comprising heating the juice; adding
`
`gelling additive; steering the mixture until the mixture is fully homogenous; and
`
`cooling the mixture so as to produce jelly.
`
`5
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, said gelling additive is selected of a group comprising agar
`
`agar, tragacanth gum, gelatine, or pectin.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, the process further comprising adding lemon juice.
`
`10
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, the process further comprising adding oil and adding
`
`lechitin so as to produce paste adapted for spreading.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, said oil is olive oil.
`
`15
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, the process further comprising adding medical herbs.
`
`It is further provided in accordance with another preferred embodiment of
`
`the present invention, a method of reducing homocystein levels as well as
`
`reducing the cholesterol levels in the blood among other therapeutic effects by
`
`20
`
`orally administering a subject with beta vulgaris-based composition prepared
`
`by a process comprising:
`
`preparing juice from beta vulgaris root;
`
`drying said juice into powder;
`
`Furthermore, in accordance with another preferred embodiment of the
`
`25
`
`present invention, the process further comprising encapsulating said powder.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, said beta vulgaris is a red beet.
`
`In addition, it is provided in accordance with yet another preferred
`
`embodiment of the present invention, a method of reducing effects of
`
`30
`
`gynecologic problems such as menopause, PMS, and fertility problems by
`
`orally administering a female with red beet-based composition comprising:
`
`dry red beet extract;
`
`Page 5 of 17
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`PCT/IL2004/001179
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`5
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`dry pomegranate extract;
`
`additives selected of a group comprising cimicifuga
`
`racemosa, fatty acid - gla, ferulic acid, chamaelirium luteum, and
`
`vitex agnus castus.
`Further, in accordance with an additional embodiment of the present
`
`5
`
`invention, a method of increasing the blood count of a subject, especially a
`subject going through a chemotherapy treatment, by orally administering the
`subject with red beet-based composition comprising:
`
`IO
`
`15
`
`dry red beet extract;
`
`dry astragalus membranaceus extract;
`
`Yet,
`in accordance with another preferred embodiment of the present
`invention, a method of increasing the blood count of a subject, especially a
`
`subject going through a chemotherapy treatment, by orally administering the
`subject with red beet-based composition comprising:
`
`dry red beet extract;
`dry withania somniferum extract;
`
`It is also provided in accordance with another preferred embodiment of
`the present invention, a method of treating skin diseases such as seborrhea
`
`and seborrheic dermatitis by externally spreading the subject with products
`
`20
`
`adapted for external use comprising juice extracted from beta vulgaris root.
`
`Furthermore, in accordance with another preferred embodiment of the
`
`present invention, said beta vulgaris is a red beet.
`additionally, in accordance with another preferred embodiment of the
`
`present invention, Resulting products made by the methods in Claims 1 - 21.
`
`25
`
`DETAILED DESCRIPTION OF THE INVENTION
`
`The present invention provides unique and novel beta vulgaris-based
`products as well as methods for producing the products that preserve the
`
`30
`
`therapeutic influence of the components contained in the beta vulgaris and
`especially in red beet species. Red beet contains substances that had been
`
`Page 6 of 17
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`PCT/IL2004/001179
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`6
`
`shown to have therapeutic effect on the body. It is important to preserve the
`
`activity of the components when producing the products. In addition, red beet
`
`has side tastes that are not favorable when eating the product itself and the
`
`methods of producing the products of the present invention eliminate the
`
`5
`
`unfavorable taste of the red beet so as to allow producing products such as
`
`beverages that are tasty and can be consumes by many populations.
`
`The present invention provides a main aspect by which a juice made of
`
`red beet is produces wherein the juice can be produces from the root, pilled or
`
`un-pilled, from the leaves or from both. It is then being sweetened so as to
`
`10
`
`eliminate any bad taste and can be fermented so as to establish an alchoholic
`
`beverage. Moreover,
`
`fermentation
`
`is known
`
`to
`
`increase the biological
`
`availability of active components in the body therefore, fermenting the red
`
`beet should
`
`increase
`
`the biological availability of the specific active
`
`components in the red beet to the body. The juice can be filtered and used for
`
`15
`
`other products. Following are examples of producing red beet based products.
`
`Example 1:
`
`Stages in the preparation of alcoholic beverage:
`
`1. Preparing juice from a red beet root (with or without the peel):
`
`20
`
`Extracting the juice from the beet using a juice extractor, for example.
`
`The red beet can be slightly heated so as to facilitate the peeling of the
`
`peel in case peeling is desired.
`
`2. Adding sugar based component to the juice to facilitate fermentation.
`
`The sugar based component can be chosen of a group comprisin.g fruit
`
`25
`
`extract
`
`(preferably apple extract), beet molasses, sugar cane
`
`molasses, honey, maltose, brown or white sugar, sweet pomegranate
`
`extract. The percentage of sugar component depends on the final
`
`alcohol level that is required for the beverage. It is preferable that the
`
`final amount of sugar content in the mixture will be substantially 25% so
`
`30
`
`that the final percentage of alcohol will stand substantially on 12%.
`
`3. Adding yeasts in case non-natural fermentation is desired.
`4. Fermenting the resulting mixture.
`
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`PCT/IL2004/001179
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`7
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`5. Filtering the mixture so as to obtain the fluid.
`
`It is optional, however preferable to maintain the mixture in an oak barrel
`
`so as to improve the flavor and aroma of the beverage.
`
`Optionally, the fermentation process can be extended to a malolactic
`
`5
`
`fermentation as well.
`
`Other materials can be added into the beverage such as spices and
`
`medical herbs so as to improve the taste and the quality of the beverage.
`
`Optionally, chips of oak tree can be also added after the fermentation process
`
`is finished. Whisky or other alcoholic drinks can be also added.
`
`10
`
`In order to produce a sweet beverage, oligofructose or oligosaccharides
`
`can be added. Any other additives that are added into the red beet root based
`
`alcoholic beverage are covered by the scope of the present invention.
`
`Based on this preparation, vinegar or seasoning product can be
`
`produced.
`
`15
`
`It should be mentioned that the alcoholic beverage is a preferable
`
`beverage due to the importance of alcohol consumption in relative low
`
`quantities on well being. It had been shown that moderate consumption of
`
`alcohol has a protective effect over the heart. The increase in homocystein in
`
`the blood that might be also a consequence of alcohol consumption is
`
`20
`
`eliminated due to the fact that the red beet contains also folic acid, vitamin 86,
`
`and betain that cause an opposing effect on homocystein as mentioned
`
`herein before.
`
`An additional reason for the preference of alcoholic beverages is that the
`
`fermentation process
`
`increases
`
`the biological availability of certain
`
`25
`
`components. Alcohol also decreases stress and gives a synergistic effect with
`
`the active components in the red beet, which are triterpen saponins that
`
`provides the red beet with adaptogenic activity. Stress by itself imparts risk of
`
`atherosclerosis so this risk is also reduced due to drinking the red beet-based
`
`alcoholc drink of the present invention.
`
`30
`
`Since alcohol can have a negative effect on the liver, incorporating the
`
`alcohol with the red beet components that are known to have a protective
`
`effect on the liver, as mentioned herein before, is preferable.
`
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`8
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`Example 2:
`
`The stages for the production of vinegar or seasoning are as follows:
`
`1. Preparing juice from a red beet root (with or without the peel).
`
`5
`
`2. Adding sugar based component
`
`to
`
`the
`
`juice
`
`for
`
`fermentation.
`
`Optionally, the fermentation process can be based on the natural
`
`content of sugar that is present in the beet itself. If sugar from another
`
`source is added, the percentage of sugar should not exceed 18%.
`
`3. Adding yeasts in case non-natural fermentation is desired.
`
`10
`
`4. Fermenting the resulting mixture.
`5. allowing natural acidation.
`6. Filtering the mixture so as to obtain the fluids.
`
`7. Adding bacteria (such as acetic acid bacteria) so as to sour the liquid.
`
`15
`
`Example 3:
`
`Another product based on the root of a red beet is a jelly or delicacy.
`
`The stages for preparing a jelly comprises:
`
`1. Preparing a juice from a red beet root (with or without the peel).
`
`2. Adding sugar based component or sugar substitute. The sugar based
`
`20
`
`component can be chosen of a group comprising
`
`fruit extract
`
`(preferably apple extract), beet molasses, sugar cane molasses,
`
`honey, maltose, brown or white sugar, oligofructose, oligosaccharide,
`
`or stevioside. Oligofructose and oligosaccharide are preferred in gelly
`
`based foods. Adding the sugar can be performed after other stages as
`
`25
`
`well, so as to improve the taste.
`
`3. Heating the mixture.
`
`4. Adding lemon juice.
`
`5. Adding gelling additive. The gelling substance can be chosen from a
`
`group consisting of agar agar, tragacanth gum, gelatine, or pectin. Any
`
`30
`
`other additive that forms gelation is covered by the scope of the
`
`present invention.
`
`6. Steering the mixture until the mixture is fully homogenous.
`
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`9
`
`7. Cooling the mixture.
`
`This product can be improved by sweetening components, spices or
`herbs.
`
`This product
`the
`the cholesterol and
`redu.cing
`for
`is adapted
`homocysteine levels in the blood as well as improving the functionality of the
`
`5
`
`liver. T.he gelling product can also improve and enhance the intestinal activity,
`
`to reduce the appetite, and to reduce markedly the risks for large intestine
`
`cancer, especially when sweetened with oligofructose or oligosaccharides.
`
`10
`
`Example 4:
`
`An additional beverage that can be produces from red beet is a juice. The
`preparation comprises the following stages:
`
`1. Preparing juice from a red beet root (with or without the peel).
`2. Adding sweetening agent.
`
`15
`
`3. Optionally, adding carbon dioxide for producing a gaseous beverage.
`
`4. Optionally, adding spices or herbs or food supplements.
`
`Example 5:
`
`A dry extract from red beet can be also produced in accordance to the present
`
`20
`
`invention. The preparation comprises the following stages:
`
`1. Preparing a juice from a red beet root (with or without the peel).
`
`2. Drying the juice into a powder. Drying the juice can be performed in a
`
`freeze drying procedure, or spray drying.
`
`3. Encapsulating the powder into pills, for example.
`
`25
`
`The powder is adapted for reducing the cholesterol and the homocystein
`
`levels in the blood.
`It should be noted that incorporating medical herbs into the powder in
`
`any form can have an effect of increased blood count. This specific
`
`formulation of red beet dry extract and medical herbs, which may be for
`
`30
`
`example dry astragalus membranaceus extract and dry withania somniferum
`
`extract, can have a tremendous influence as a supportive treatment on cancer
`
`patients that are being treated in a chemotherapeutic procedure.
`
`Page 10 of 17
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`10
`
`Example 6:
`
`An additional product based on red beet juice or squash is a paste. The paste
`
`preparation comprises the following stages:
`
`5
`
`1. Preparing juice from a red beet root (with or without the peel).
`
`2. Adding olive oil.
`3. Adding lecithin.
`
`The paste can be used for spreading on bread, for example.
`
`10
`
`Example 7:
`
`A composition especially for woman with gynecologic problems such as
`
`menopause, PMS, and fertility problems, is produced through from the
`following components:
`1. Dry red beet extract.
`
`15
`
`2. Dry pomegranate extract.
`
`3. Additional additives such as cimicifuga racemosa, fatty acid - gla,
`
`ferulic acid, chamaelirium luteum, and vitex agnus castus.
`
`As mentioned herein before, other additives can be added into the
`
`mixtures that produce the different products as disclosed herein. Examples for
`
`20
`
`herbs that can be added separately or more than one herb are as follows:
`
`silybum marianum,
`
`taraxacum spp., curcuma spp., cynara scolymus,
`
`commiphora mukul, ganoderma lucida, gymnema sylvestre, allium sativum,
`
`trigonella foenum-graecum, atriplex spp., pterocarpus marsupium, momordica
`
`chrantia, vaccinium myrtillus, panax spp., vanilla spp. coriandrum sativum.
`
`25
`
`Piper nugrum, gentiana spp.
`
`Examples for food additives are as follows: 8-complex vitamins such as
`
`folic acid, 812, 86, and niacin, Omega 3 fatty acids, chromium, vitamin C,
`
`carnitine, inulin.
`Eliminating the possible negative effects of the red beet can be
`
`30
`
`established by adding vitamin C so as to prevent formation of nitrosamines.
`
`Oxalic acid can be also eliminated. The natural sugar present in the red beet
`is eliminated in case the final product is for low calories dietary product.
`
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`11
`
`Optionally, the products can go through a sterilization process during any
`
`one of the stages.
`The beverages (alcoholic, nonalcoholic, gaseous) can optionally be
`
`mixed with juices prepared from pomegranate. The pomegranate juice can be
`5 mixed in any of the stages.
`
`While the invention has been described with reference to certain
`exemplary embodiments, various modifications will be readily apparent to and
`
`may be readily accomplished by persons skilled in the art without departing
`
`from the spirit and scope of the above teachings.
`
`1 O
`
`It should be noted that these products can be also applied in shampoo
`
`products as well as soaps so as to treat skin diseases such as seborrhea and
`
`seborrheic dermatitis. Other products for external use can be provided with
`
`extracts of the red beet and food supplements such as 86, zinc, selenium,
`
`medical herbs such as arctum lappa, calendula officinalis, aloe spp. and urtica
`
`15
`
`spp, tabebuia spp., echinacea spp, salix spp.
`It should be also noted that the use of red beet is preferable, however,
`
`the products mentioned herein and used in the present invention can be
`produced and prepared from other beta vulgaris varieties.
`
`It should be understood that features and/or steps described with
`
`20
`
`respect to one embodiment may be used with other embodiments and that not
`
`all embodiments of the invention have all of the features and/or steps shown
`
`in a particular figure or described with respect to one of the embodiments.
`
`Variations of embodiments described will occur to persons of the art.
`
`It is noted that some of the above described embodiments may
`
`25
`
`describe the best mode contemplated by the inventors and therefore include
`
`structure, acts or details of structures and acts that may not be essential to the
`
`invention and which are described as examples. Structure and acts described
`
`herein are replaceable by equivalents which perform the same function, even
`if the structure or acts are different, as known in the art. Therefore, the scope
`
`30
`
`of the invention is limited only by the elements and limitations as used in the
`
`claims. The terms "comprise", "include" and their conjugates as used herein
`
`mean "include but are not necessarily limited to".
`
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`12
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`References:
`
`Bobek P et al. The effect of red beet (Beta vulgaris var. rubra) fiber on
`alimentary
`hypercho/esterolemia
`and
`chemically
`induced
`colon
`carcinogenesis in rats. Nahrung, 2000; 44(3): 184-187p.
`
`5
`
`Hagander B et al. Dietary fibre enrichment, blood pressure, lipoprotein profile
`and gut hormons in NIDDM patients. Eur J Clin Nutr 1989; 43: 35-44p.
`
`10
`
`Jones P.J.H et al. Cholesterol-lowering efficacy of a sitostanol-containing
`phytosterol mixture with a prudent diet un hyperlipidemic men. Am J Clin Nutr
`1999;69: 1144-1150p.
`
`Kahkonen M.P et al. Antioxidant activity of plant extracts containing phenolic
`compounds. J Agric Food Chem 1999; 47: 3954-3962p.
`
`15
`
`Krispil N. Beta vu/garis (Red beet) . Medical plants in Israel and through out
`the world: The complete guide 2000: 170-171p. (the book in Hebrew) [a]
`
`20
`
`Krispil N. Beta vu/garis (beet) . Medical plants in Israel and through out the
`world: The complete guide 2000: 171p. (the book in Hebrew) [b]
`
`Kujala T.S et al. phenolics and betacyanines in red beetroot (Beta vulgaris)
`root: distribution and effect of cold storage on the content of total phenolics
`and three individual compounds. J Agric Food Chem 2000; 48:5338-5342p.
`
`25
`
`Lalouschek W et al. Hyperhomocyst(e)inemia--an independent risk factor of
`stroke, Fortschr Neural Psychiatr 1996; 64(7): 271-277p.
`
`30
`
`PDR for herbal monographs. Beta Vulgaris. 1th Edition 1999: 505-523p.
`
`Sella B.A & Dolman R. Dialysis attended and organs transplanted that
`consume Cyclosporin: tow sectors of patients with high levels of Homocystein,
`Harefua 1999; 136(3): 218-222p. (the article in Hebrew)
`
`35
`
`Shils M.E et al. Nutrition and the immune system, 9th Edition. Modern nutrition
`
`in health and disease 1999: 741-742p.
`
`Weiss R. F. Beta vulgaris (Sugar Beet). Herbal Medicine 1988: 89p.
`
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`PCT/IL2004/001179
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`13
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`CLAIMS
`
`1.
`
`A method of reducing homocystein levels as well as reducing the
`
`cholesterol levels in the blood among other therapeutic effects by orally
`
`5
`
`administering a subject with beta vulgaris-based composition prepared
`
`by a process comprising:
`
`preparing juice from beta vulgaris root;
`
`adding sweetening agent;
`
`filtering the resulting juice.
`
`IO
`
`2.
`
`The method as claimed in Claim 1, wherein the process further
`
`comprising
`
`fermenting the mixture;
`
`15
`
`3.
`
`The method as claimed in Claim 1, wherein the process further
`
`comprising:
`
`adding carbon dioxide.
`
`4.
`
`The method as claimed in Claim 1, wherein the process further
`
`20
`
`comprising:
`
`adding yeasts;
`
`fermenting the resulting juice.
`
`5.
`
`The method as claimed in Claim 1, wherein said beta vulgaris root is
`
`. 25
`
`pilled .
`
`6.
`
`The method as claimed in Claim 1, wherein said beta vulgaris is red
`
`beet.
`
`30
`
`7.
`
`The method as claimed in Claim 1, wherein said sweetening agent is
`
`selected from a group comprising
`
`fruit extract (preferably apple
`
`extract), beet molasses, sugar cane molasses, honey, maltose, brown
`
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`14
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`or white
`
`sugar,
`
`sweet pomegranate extract,
`
`oligofructose,
`
`oligosaccharides.
`
`8.
`
`5
`
`The method as claimed in Claim 1, wherein the process further
`comprising:
`
`fermenting the resulting juice;
`
`allowing natual acidation.
`
`filtering the juice;
`
`adding bacteria;
`
`10
`
`so as to produce vinegar or seasoning.
`
`9.
`
`The method as claimed in Claim 1, wherein the process further
`
`comprising:
`
`heating the juice;
`
`adding gelling additive;
`
`steering the mixture until the mixture is fully homogenous;
`cooling the mixture;
`
`so as to produce jelly.
`
`15
`
`20
`
`10.
`
`The method as claimed in Claim 8, wherein said gelling additive is
`
`selected of a group comprising agar agar, tragacanth gum, gelatine, or
`
`pectin.
`
`25
`
`11.
`
`The method as claimed in Claim 8, wherein the process further
`
`comprising:
`
`adding lemon juice.
`
`12.
`
`The method as claimed in Claim 1, wherein the process further
`
`30
`
`comprising:
`
`adding oil;
`
`adding lechitin;
`
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`PCT/IL2004/001179
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`15
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`so as to produce paste adapted for spreading.
`
`13.
`
`The method as claimed in Claim 11, wherein said oil is olive oil.
`
`5
`
`14.
`
`The method as claimed in Claim 1, wherein the process further
`
`comprising:
`
`adding medical herbs.
`
`15.
`
`A method of reducing homocystein . levels as well as reducing the
`
`1 O
`
`cholesterol levels in the blood among other therapeutic effects by orally
`
`administering a subject with beta vulgaris-based composition prepared
`by a process comprising:
`
`preparing juice from beta vulgaris root;
`
`drying said juice into powder;
`
`15
`
`16.
`
`The method as claimed in Claim 14, wherein the process further
`
`comprising:
`
`encapsulating said powder.
`
`20
`
`17.
`
`The method as claimed in Claim 15, wherein said beta vulgaris is a red
`beet.
`
`18.
`
`A method of reducing effects of gynecologic problems such as
`
`menopause, PMS, and fertility problems by orally administering a
`
`25
`
`female with red beet-based composition comprising:
`
`dry red beet extract;
`
`dry pomegranate extract;
`
`additives selected of a group comprising cimicifuga
`
`racemosa, fatty acid - gla, ferulic acid, chamaelirium luteum, and
`
`30
`
`vitex agnus castus.
`
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`16
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`PCT/IL2004/001179
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`19.
`
`A method of increasing the blood count of a subject, especially a
`
`subject going
`
`through a chemotherapy
`
`treatment, by orally
`
`administering the subject with red beet-based composition comprising:
`
`dry red beet extract;
`
`5
`
`dry astragalus membranaceus extract;
`
`20.
`
`A method of increasing the blood count of a subject, especially a
`subject going
`through a chemotherapy
`treatment, by orally
`
`administering the subject with red beet-based composition comprising:
`
`10
`
`dry red beet extract;
`dry withania somniferum extract;
`
`21. A method of treating skin diseases such as seborrhea and seborrheic
`
`dermatitis by externally spreading the subject with products adapted for
`
`15
`
`external use comprising juice extracted from beta vulgaris root.
`
`22. A method as claimed in Claim 20, wherein said beta vulgaris is a red
`
`beet.
`
`20
`
`23. Resulting products made by the methods in Claims 1 - 22.
`
`SUBSTITUTE SHEET (RULE 26)
`
`Page 17 of 17
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`