R
`11
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`THE JOURNAL
`THE JOURNAL
`
`OF
`()F
`
`CLINICAL INVESTIGATION
`CLINICAL INVESTIGATION
`
`VOLUME XXXVI
`VOLUME XXXVI
`1957
`1957
`
`THE AMERICAN SOCIETY FOR CLINICAL INVE STIGATION
`THE AMERICAN SOCIETY FOR CLINICAL INVESTIGATION
`
`PUBLISHED BY
`PU BLI S H E D BY
`
`Patent Owner Ex. 2026 - Page 1 of 23
`
`Pharmacosmos V. American Regent - PGR2020-00009
`
`

`

`PHILIP K. BONDY, Editor-in-Chief
`Associate Editors
`FRANKLIN H. EPSTEIN
`ALLAN V. N. GOODYER
`
`EDITORIAL COMMITTEE
`
`THOMAS P. ALMY
`ROBERT w. BERLINER
`FRANCIS P. CHINARD
`GEORGE L. CURRAN
`
`LEWIS DEXTER
`LEONARD P. ELIEL
`WARD S. FOWLER
`
`ROBERT A. Goon
`JOHN B. HICKAM
`EDWARD C. R.EIFENSTEIN, JR.
`ARNOLD s. RELMAN
`I. HERBERT ScHEINBERG
`JOHN V. TAGGART
`RICHARD w. VILTER
`LAWRENCE E. YOUNG
`
`

`

`CONTENTS
`
`NUMBER 1, PART I, JANUARY, 1957
`
`A Standardized Breath Holding Technique for the Clinical Measurement of the Diff u!ling
`Capacity of the Lung for Carbon Monoxide. C. M. OGILVIE, R. E. FORSTER, W. S.
`BLAKEMORE, AND J. w. MORTON ........................................... ...•..
`The Plasma Disappeara nce, Excretion, and Tissue Distribution of Cobalt'° Labelled Vitamin
`B12 in Normal Subjects and Patients with Chronic Myelogenous Leukemia. AARON
`MILLER, HOWARD F. CORBUS, AND JOHN F. SULLIVAN ..................... .. . .... ,..
`The Influence of Extracellular Thyroxine-Binding Protein upon the Accumulation of Thy(cid:173)
`roxine by Tissue Slices. NORBERT FREINKEL, SIDNEY H. INGBAR, AND J. THOMAS
`DOWLING.... ....... ... ... .. ... ..... ... . .............. .... ... . . . ...............
`I. Histamine and Proteins.
`Substances Released from the Skin Following Thermal Injury.
`SoL Roy RosENTHAL, CHARLES SAMET, RICHARD J. WINZLER, AND SELWYN SHKOLNJK. .
`Chemical and Biological Alterations Induced by Irradiation of 1111 Labeled Human Serum
`Albumin. ROSALYN S. YALOW AND SOWMON A. BERSON.... . . . . . . . . . . . . . . . . . . . .
`. • .
`The Hexosamine Content of the Serum Globulins in Normal and Pathological Sera. ALFRHO
`JAY BOLLET....... ........... .. ............ . . . ... . .... ... ..... .. ..........
`Pulmonary and Circulatory Effects of Acute Pulmonary Vascular Engorgement in Normal
`Subjects. STUART BONDURANT, JOHN B. HICKAM, AND JOSEPH K. ISLEY ..............
`The Effect of Intravenous Cortisol Injections on the Plasma Cortisol Concentration in Man.
`JAMES ScHEUER AND PHILIP K. BONDY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
`The Effect of Glucagon on the Blood Glucose Level and the Clinical State in the Presence of
`Marked Insulin Hypoglycemia.
`JEROME L. ScHULMAN AND STANLEY E. GREBEN. . . . . •
`Weight Gain from Simple Overeating.
`II. Serum Lipids and Blood Volume. JOSEPH T.
`ANDERSON, ADRIAN LAWLER, AND ANCEL KEYS.... . .... .. ... ..... .. .. ... .........
`Urinary Hemoglobin Excretion and Renal Circulatory Dynamics: A Study of the Effect of
`L-Norepinephrine in the Dog. WILLOUGHBY LATHEM AND ALVIN D. BENJMUN. .... . ..
`
`18
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`2S
`
`38
`
`44
`
`51
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`59
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`6 7
`
`74
`
`81
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`89
`
`The Renal Lesion in Epidemic Hemorrhagic Fever. JEAN OLIVER AND MURIEL MACDOWELL.
`
`99
`
`NUMBER 1, PART II, JANUARY, 1957
`
`NUMBER 2, FEBRUARY, 1957
`
`Electrophoretic Studies of Red Cell Extracts of Stored Blood. EDWARD R. BERRY AND
`ALFRED CHANUTIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
`I. The Formation of Certain
`The Biosynthesis of the Fatty Acids of the Plasma of Man.
`Chromatographically Separated Higher Fatty Acids of the Major Lipide Complexes from
`Acetate-1- C14• s. R. LIPSKY, A. HAAVIK, C. L. HOPPER, AND R. w. MCDIVITT.. ..... 233
`Rapid and Slow Components of the Circulation in the Human Forearm. EDWARD D. FREIS,
`HAROLD W. ScHNAPER, AND LAWRENCE S. LILIENFIELD... ... . ...... .. ... ........... 245
`The Glucose Metabolism of Patients with Malignant Disease and of Normal Subjects as
`Studied by Means of an Intravenous Glucose Tolerance Test. PAUL A. MARKS AND
`JONATHAN s. BISHOP................................................ ............ 254
`Absorption of Water and Sodium from the Small Intestine of Patients with Nontropical
`Sprue. J OBN A. HIGGINS, PHILIP R. LEE, JOHN F. ScHOLER, RICHARD J. REITEMEIER,
`CHARLES F. CODE, AND ERICE. WOLLAEGER.......................... .... .. ... . .. 265
`Adaptive Value of Respiratory Adjustments to Shunt Hypoxia and to Altitude Hypoxia.
`GEORGE HUSSON AND A. B. OTIS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 270
`iii
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`

`

`lV
`
`CONTENTS
`
`III. The Equilibration of Radiobromide in Gastro(cid:173)
`Gastrointestinal Water and Electrolytes.
`intestinal Contents and the Proportion of Exchangeable Chloride (Cl.) in the Gastro(cid:173)
`intestinal Tract. N. J. SWEET, J. NADELL, AND I. s. EDELMAN...................... 279
`Gastrointestinal Water and Electrolytes.
`IV. The Equilibration of Deuterium Oxide (D,O)
`in Gastrointestinal Contents and the Proportion of Total Body Water (T.B.W.) in the
`Gastrointestinal Tract. F. GoTCH, J. NADELL, AND I. s. EDELMAN................... 289
`The Chemical Estimation of Acy! Glucuronides and Its Application to Studies on the Metabo-
`lism of Benzoate and Salicylate·in Man. DAVID ScHACHTER......................... 297
`Oral Sodium Loading in Normal Individuals. KEHL MARKLEY, MANUEL BOCANEGRA,
`GUILLERMO MORALES, AND MIGUEL CHIAPPORI. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303
`Objective Evaluation of Patients with Rheumatic Diseases.
`II. Paper Electrophoretic
`Studies of Serum Glycoprotein and Protein from Patients with Rheumatoid Arthritis.
`GEORGE STIDWORTHY, R. W. PAYNE, CLARA L. SHETLAR, AND M. R. SHETLAR......... 309
`The Absorption of Radioiron Labeled Foods and Iron Salts in Normal and Iron-Deficient
`Subjects and in Idiopathic Hemochromatosis. ROBERT B. CHODOS, JOSEPH F. Ross,
`LEONARD APT, MYRON POLLYCOVE, AND JAMES A. E. HALKETT............. . .... . ... 314
`An Evaluation of the Single Injection Thiosulfate Method for the Measurement of Extra-
`cellular Water. LEON C. CHESLEY AND ABRAHAM LENOBEL......................... 327
`The Hemodynamic Response to Lanatoside C of Dogs with Experimental Aortic-Caval
`Fistulas. OSCAR W. SHADLE, THOMAS B. FERGUSON, DAVID C. SABISTON, JR., AND
`DONALD E. GREGG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335
`The Distribution of Sodium and Chloride and the Extracellular Fluid Volume in the Rat.
`DONALD B. CHEEK, CLARK D. WEST, AND CATHERINE CARTER GOLDEN. . . . . . . . . . . . . . . 340
`Incorporation of N 16-L-Aspartic Acid into the Abnormal Serum and Urine Proteins of Multiple
`Myeloma (Studies of the Inter-Relationship of these Proteins). ELLIOTT F. OssERMAN,
`ADA GRAFF, MARGARET MARSHALL, DOLORES LAWLOR, AND SAMUEL GRAFF. .......... 352
`
`NUMBER 3, MARCH, 1957
`
`The Metabolism of Ammonia and a-Keto-Acids in Liver Disease and Hepatic Coma. W. H.
`J. SUMMERSKILL, STANLEY J. WOLFE, AND CHARLES S. DAVIDSON..................... 361
`The Internal Distribution of Hydrogen Ions with Varying Degrees of Metabolic Acidosis.
`WILLIAM B. ScHWARTZ, KARL J. ~RNING, AND RICHARD PORTER. . . . . . . . . . . . . . . . . . . . . . 373
`A Study of the Mechanism of Secretion of the Sodium-Retaining Hormone (Aldosterone).
`JOHN H. LARAGH AND HERBERT C. STOERK............................... . ... . .... 383
`Physical Binding of Insulin by Gamma Globulins of Insulin-Resistant Subjects. BELTON
`A. BURROWS, THEODORE PETERS, AND FRANCIS C. LOWELL. . . . . . . . . . . . . . . . . . . . . . . . . . 393
`Plasma Protein Synthesis in the Human Fetus and Placenta. JOSEPH DANCIS, NANCY
`BRAVERMAN, AND JOHN LIND............................................ . ....... 398
`Antibody Protein Synthesis by Lymph Nodes Homotransplanted to a Hypogammaglobulinemic
`Adult. CHRISTOPHER M. MARTIN, JOHN B. WAITE, AND NORMAN B. McCULLOUGH.... 405
`The Effect of Large Doses of Desiccated Thyroid on the Distribution and Metabolism of
`Albumin-1181 in Eu thyroid Subjects. MARCUS A. ROTHSCHILD, ARTHUR BAUMAN, ROSALYN
`S. YALOW, AND SOLOMON A. BERSON. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 422
`Erythrocyte Preservation. VIII. Metabolic Degradation of Nucleosides In Vitro and In Vivo.
`MARION HENNESSEY, CLEMENT A. FlNCH, AND BEVERLY WESCOTT GABRIO............ 429
`Experimental Studies of the Mechanisms Producing Hypocakemia in Hypernatremic States.
`LAURENCE FINBERG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 434
`III. Measurements of Mechanics
`Studies of Respiratory Physiology in the Newborn Infant.
`of Respiration. C. D. CooK, J . M. SUTHERLAND, S. SEGAL, R. B. CHERRY, J. MEAD, M. B.
`MCILROY, AND C. A. SMITH...................................................... 440
`
`

`

`CONTENTS
`
`\'
`
`A New Method for Measuring Sialic Acid Levels in Serum and Its Application to Rheumatic
`Fever. EUGENE L. HESS, ALVIN F. COBURN, RICHARD C. BATES, AND PRISCILLA
`MURPHY... ....................... . ... .. .......................... • . . . . . . . • . 449
`Physico-Chemical and Immunologic Studies on Macroglobulins. A. H. SEHON, I... GVEl'ffiS,
`J. GORDON, M. RICHTER, AND B. ROSE.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . •
`A Study in Dogs of Methods Suitable for Estimating the Rate of Myocardial Uptake of Rb11 in
`Man, and the Effect of L-Norepinephrine a nd Pitressin® on Rb84 Uptake. W. D. Love
`AND G. E. B URCH. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
`. .
`Differences in the Rate of Rb88 Uptake by Several Regions of the Myocardium of Control Dog
`and Dogs Receiving L-Norepinephrine or Pitressin®. W. D. LOVE AND G. E. BuRCH... 479
`I. Segregation of an Hereditary Hemorrhagic State from the Hetero(cid:173)
`Stuart Clotting Defect.
`geneous Group Heretofore Called "Stable Factor" (SPCA, Proconvertin, Factor VI I)
`Deficiency. CECIL HouGIE, EMILY 1\1. BARROW, AND JOHN B. GRAHAM . .. .....
`II. Genetic Aspects of a 'New' Hemorrhagic State. }ORN B. GRA-
`Stuart Clotting Defect.
`HAM, EMILY M. BARROW, AND CECIL HOUGIE ................. . .. .. ... ... .. . ...... , 497
`Age Differences in the Intravenous Glucose Tolerance T ests and the Response to Insulin.
`FELIX A. SILVERSTONE, MARTIN BRANDFONBRENER, NATHAN w. SHOCK, AND MARVIN
`J. YIENGST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 504
`
`4S0
`
`468
`
`485
`
`NUMBER 4, APRIL, 1957
`
`The Renal Response in Man to Acute Experimental Respiratory Alkalosis and Acidosis. E. S.
`BARKER, R. B. SINGER, J . R. ELKINTON, AND J. K. CLARK..... ...... .. ...... . . . .... 515
`Bile Acid Content of Human Serum.
`I. Serum Bile Acids in Patients with Hepatic Disease.
`DANIEL RUDMAN AND FORREST E. KENDALL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 530
`Bile Acid Content of Human Serum.
`II. The Binding of Cholanic Acids by Human Plasma
`Proteins. DANIEL RUDMAN AND FORREST E. KENDALL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 538
`Inhibitory Effect of Chlorpromazine upon the Adrenal Cortical Response to Insulin Hypo(cid:173)
`glycemia in Man. NICHOLAS P . CHRISTY, DONALD LoNGSON, WILLIAM A. HORWITZ, AND
`MARY M. KNIGHT. ............... . .............. . ...... . ............... ... . .... 543
`Renal Reabsorption of Phosphate in Normal Human Subjects and in Patients with Parathyroid
`Disease. DAVID D. THOMPSON AND HOWARD H. HIATT....................... . .. ... 550
`The Effects of Parathyroid Extract on Renal Function in Man. HOWARD H. HIATT AND
`DAVID D . THOMPSON...... .... . . . ... ............ .... ............... ......... . .. 557
`Effects of Phosphate Loading and Depletion on the R enal Excretion and Reabsorption of
`Inorganic Phosphate. DAVID D. THOMPSON AND HOWARD H. HIATT... ... .. ........ . 566
`Some Effects of Intravenously Administered Calcium on Inorganic Phosphate Metabolism.
`HOWARD H . HIATT AND DAVID D. THOMPSON.... .. ........... . .... . . . ............. 573
`The Dynamics of Swallowing.
`I. Normal Pharyngeal Mechanisms. MICHAEL ATKINSON,
`PHILIP KRAMER, STANLEY M. WYMAN, AND FRANZ J. INGELFINGER... . ....... ........ 581
`The Dynamics of Swallowing.
`II. Neuromuscular Dysphagia of Pharynx. PHILIP KRAMER,
`MICHAEL ATKINSON, STANLEY M. WYMAN, AND FRANZ J. INGELFINGER ............... 589
`A Heparin-Precipitable Fraction of Human Plasma.
`I. Isolation and Characterization of
`the Fraction. RICHARDT. SMITH AND RICHARD W. VoN KORFF. ....... . .. .. . ........ 596
`A Heparin-Precipitable Fraction of Human Plasma.
`II. Occurrence and Significance of the
`Fraction in Normal Individuals and in Various Disease States. RICHARD T. SMITH.... 605
`The Mechanism of Glutathione Destruction and Protection in Drug-Sensitive and Non-Sensi-
`tive Erythrocytes. In Vitro Studies. ERNEST BEUTLER, MELBA ROBSON, AND ELLEN
`BurrENWIESER......... . .... .. ................ . ....... .. .. ..... . . .. ............ 617
`
`

`

`Vt
`
`CONTENTS
`
`NUMBER 5, MAY, 1957
`
`The Influence of Bodily Hydration on the Renal Concentrating Process. FRANKLIN H.
`EPSTEIN, CHARLES R. KLEEMAN, AND ACHIEL HENDRIK.X....... .. . . ..... . ........... 629
`The Effect of Feeding Protein and Urea on the Renal Concentrating Process. FRANKLIN
`H. EPSTEIN, CHARLES R. KLEEMAN, STEWART PURSEL, AND ACHIEL HENDRIKX........ 635
`Ethanol Fractionation of Plasma and Electrophoretic Identification of Insulin-Binding Anti(cid:173)
`body. SOLOMON A. BERSON AND ROSALYN S. YALOW..... . . . . . . . . .................. 642
`Apparent Inhibition of Liver Insulinase Activity by Serum and Serum Fractions Containing
`Insulin-Binding Antibody. ROSALYN s. YALOW AND SOLOMON A. BERSON..... . . . . . . . . 648
`Studies on Structure Diuretic Activity Relationships of Organic Compounds of Mercury. R.
`H. KESSLER, R. LOZANO, AND R. F. PITTS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 656
`The Effects of Pharmacologic Agents on the Pulmonary Circulation in the Dog. Studies on
`Epinephrine, Nor-Epinephrine, 5-Hydroxytryptamine, Acetylcholine, Histamine, and
`Aminophylline. HANS G. BORST, ERIK BERGLUND, AND MAURICE McGREGOR. . . . . . . . . 669
`The Distribution of Fe69 Tagged Human Erythrocytes in Centrifuged Specimens as a Function
`of Cell Age. E. RAYMOND BORUN, WILLIAM G. FIGUEROA, AND SEYMOUR M. PERRY.... 676
`Strontium86 and Calcium'6 Metabolism in Man. HERTA SPENCER, DANIEL LASZLO, AND
`MILTON BROTHERS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 680
`Increased Aldosterone Secretion in Dogs with Right-Sided Congestive Heart Failure and in
`]AMES 0. DAVIS, MAURICE M.
`Dogs with Thoracic Inferior Vena Cava Constriction.
`PECHET, WILMOT C. BALL, ]R., AND M. JAY GOODKIND...... . .......... . ........... 689
`The Distribution of Cr61 Labeled E. Coli Endotoxin in the Generalized Shwartzman Reaction.
`RICHARDT. SMITH, ABRAHAM I. BRAUDE, AND FRANCIS J. CAREY... . ........... . ..... 695
`In Vivo Studies of the Role of Albumin in Endogenous and Heparin-Activated Lipemia-Clear-
`ing in Nephrotic Rats. RAY H. ROSENMAN AND MEYER FRIEDMAN..... . . . . . . . . . . . . . . 700
`Biochemical Observations on the Use of L-Glutamic Acid in the Treatment of Hepatic Coma.
`FRANK L. IBER AND THOMAS C. CHALMERS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 706
`Ultracentrifugal Characterization of the Lipoprotein Spectrum in Obstructive Jaundice:
`Studies of Serum Lipid Relationships in Intra- and Extrahepatic Biliary Obstruction.
`ROBERT H. FURMAN AND LOYALL. CONRAD................................. . ...... 713
`Net Potassium Movement Between Resting Muscle and Plasma in Man in the Basal State and
`During the Night. REUBIN ANDRES, GORDON CADER, PETER GOLDMAN, AND KENNETH
`L. ZIERLER. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 723
`Movement of Potassium into Skeletal Muscle During Spontaneous Attack in Family Periodic
`Paralysis. KENNETH L. ZIERLER AND REUBIN ANDRES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 30
`I. Ultrafiltration Methods and Normal Values.
`The Ultrafiltrable Calcium of Human Serum.
`T. Y. TORIBARA, A. RAYMOND TEREPKA, AND PRISCILLA A. DEWEY... .. .. ... .. . . ..... 738
`A and B Antigens in the Human Epidermis. D. NELKEN, J. GUREVITCH, AND Z. NEUMAN . . 749
`
`NUMBER 6, PART I, JUNE, 1957
`
`The!Hereditary Transmission of Hemoglobin Differences in Mice. SALOME GLUECKSOHN(cid:173)
`WAELSCH, HELEN M. RANNEY, AND BETTY F. SISKEN.................... . ..... . .... 753
`Aldosterone Excretion in Normal Subjects Depleted of Sodium and Potassium. BEN B.
`JOHNSON, AMos H. LIEBERMAN, AND PATRICK J. MULROW........................... 757
`The Effects of Cortisone and Hydrocortisone on Water Diuresis and Renal Function in Man.
`LAWRENCE G. RAISZ, WILLIAM F. McNEELY, LAWRENCE SAXON, AND JACK D. ROSEN-
`BAUM...... . ........ ... ............. . ....... ... ....... . . ... . ............... . .. 767
`An Electrophoretic Study of Serum Proteins in Thyroiditis. NORMAN WEISSMAN AND MARTIN
`PERLMUTTER..... ... . ............... . ........ ......... . ....................... . 780
`
`

`

`CONTENTS
`
`vii
`
`), and Deuterium Oxide (0.0)
`The Equilibration of Radiosodium (Na2'), Radiopotassium (K0
`in Hydropic Human Subjects. M. P. O'MEARA, L. W. BIRKENFELD, F . A. GOTCH, AND
`I. S. EDELMAN . . .... . ... .. .. . . .. ....... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • • 7 4
`The Response of Rheumatic and Non-Rheumatic Children to Streptolysin O Concentrate.
`ROBERT w. QUINN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . • • • 793
`The Concentration and Binding of Thyroxine and Triiodothyronine by Rat Diaphragm.
`JOHN R. HoGNESS, NORMAND. LEE, MARGARET K. BERG, AND ROBERT ff. WILLIAMS .. 803
`II. The Transport Function of Unestcrified
`Unesterified F atty Acid in Human Blood Plasma.
`Fatty Acid. ROBERTS. GORDON, JR.. . .. ..... . ......... .. . ......... . . ............ 810
`Sodium Transport Across the Surface Membrane of Red Blood Cells in Hereditary Spherocyto-
`JOHN F . BERTLES... .. . . . .... ... . . ..... ........................... . ...... .. 816
`sis.
`The Acute Calcification of Tra umatized Muscle, with Particular Reference to Acute Poet(cid:173)
`Traumatic Renal Insufficiency. WILLIAM H. MERONEY, GLEN K. ARNEY, W1LLJAAf
`E. SEGAR, AND HENRY H. BALCH...... ....... .. ............... . .. ... ............. 825
`Studies on the Destruction of Red Blood Cells. XII. Fac tors Influencing the Role of S Hemo(cid:173)
`globin in the Pathologic Physiology of Sickle Cell Anemia a nd Related Disorders.
`::\10RTI-
`MER S. GREENBERG, EDWARD H. KAss, AND WILLIAM B. CASTLE. . . . . . . . . . . . . . . . . . . . 833
`Hemodynarnic Effects of Quinidine: Including Studies of Cardiac Work and Coronary Blood
`Flow. GEORGE C. ROWE, DEAN A. EMANUEL, GEORGE M. MAXWELL, JOHN F. BROWN,
`CESAR CASTILLO, BENJAMIN SCHUSTER, Q. R. MURPHY, AND CHARLES W . CRUMPTON... 844
`Early Effects of Fat Ingestion on Lipids and Lipoproteins of Serum in Man. RICHARD J.
`HAVEL ............ .... ...... ... ... . ...... .. ... ... ....... . ..................... 848
`Early Effects of Fasting and of Carbohydrate Ingestion on Lipids and Lipoproteins of Serum
`in Man. RICHARD J. HAVEL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 855
`The Hemodynamic Effects of Hexamethonium Bromide in the Dog, with Special Reference
`to "Splanchnic Pooling." B. COMBES, J. R. K. PREEDY, H. 0 . WHEELER, R. M. HAYS,
`AND s. E . BRADLEY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 860
`Proceedings of the Forty-Ninth Annual Meeting of the American Society for Clinical In(cid:173)
`vestigation Held in Atlantic City, N. J ., May 6, 1957 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 866
`
`NUMBER 6, PART II, JUNE, 1957
`Metabolic Studies in Paralytic Acute Anterior Poliomyelitis.
`I. Alterations in Nitrogen and
`Creatine Metabolism. G . DONALD WHEDON AND EPHRAIM SHORR.. . . . . . . . . . . . . . . . . . . 942
`Metabolic Studies in Paralytic Acute Anterior Poliomyelitis.
`II. Alterations in Calcium and
`Phosphorus Metabolism. G. DONALD WHEDON AND EPHRAIM SHORR.... . . ....... . .. . 966
`Metabolic Studies in Paralytic Acute Anterior Poliomyelitis.
`III. Metabolic and Circulatory
`Effects of the Slowly Oscillating Bed. G. DONALD WHEDON AND EPHRAIM SHORR. . . . . . . . 982
`IV. Effects of Testosterone Pro(cid:173)
`Metabolic Studies in Paralytic Acute Anterior Poliomyelitis.
`pionate and Estradiol Benzoate on Calcium, Phosphorus, Nitrogen, Creatine and Electro-
`lyte Metabolism. G. DONALD WHEDON AND EPHRAIM SHORR. . . . . . . . . . . . . . . . . . . . . . . . 995
`
`NUMBER 7, JULY, 1957
`Diastolic Gallop Sounds, the Mechanism of Production. PETER T. Kuo, TRUMAN G.
`SCHNABEL, JR., WILLIAMS. BLAKEMORE, AND ARTHUR F. WHEREAT . ........... ..... . 1035
`Radioactive Iron Metabolism and Erythrocyte Survival Studies of the Mechanism of the
`Anemia Associated with Rheumatoid Arthritis. EMIL J. FREIREICH, JOSEPH F. R oss,
`THEODORE B. BAYLES, CHARLES P. EMERSON, AND STUART C. FINCH ... .............. 1043
`A Study of the Quantitative Relationship Between Antidiuretic Hormone (Vasopressin) and
`the Renal Tubular Reabsorption of Water. WALTER HOLLANDER, JR., T. FRANKLIN
`WILLIAMS, CHRISTOPHER C. FORDHAM, III, AND LOUIS G. WELT . . . . . . . . . . . . . . . . . . . . . 1059
`
`

`

`Vlll
`
`CONTENTS
`
`Acute Respiratory lllness in Volunteers Following Intramuscular Administration of Live
`Adenovirus. M . R . HILLEMAN, R. E. HODGES, M. s. WARFIELD, AND s. A. ANDERSON .. 1072
`Pulmonary Ventilation and Diffusion in the Human Newborn Infant. MILDRED T . STAHL·
`MAN . ............... . ......... .. . . ............ . ............. . .... . ....... ..... 1081
`Type-Specific St reptococcal Antibody. FLOYD W . DENNY, JR., WILLIAM D. PERRY, AND
`L EWIS w. WANNAMAKER . .. ... .. .... .. ... . . . . . ........ . ......... . . . ...... . ... . . . 1092
`Hypoxemia and Coronary Blood Flow. ROBERT M. BERNE, }OHN R. BLACKldON, AND
`THOMAS H. GARDNER . ... .. . . ... . ... . .. ......... ........ . ....... ..... ... . ...... . 1101
`Renal Function in Wilson's Disease. A. G. BEARN, T. F. YO, AND A. B. GUTMAN ..... .. .. 1107
`Serotonin and Histamine Release During Anaphylaxis in the Rabbit. T. P. WAALKES,
`H. W EISSBACH, ] . BOZICEVICH, AND S. UDENFRIEND. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1115
`The Immediate Effects of Respiratory Depression on Acid-Base Balance in Anesthetized Man.
`DUNCAN A. HOLADAY, DOROTHY MA, AND E. M. PAPPER .. .. ......... . ...... . ...... . 1121
`An Adaptation of the Nitrous Oxide Method to the Study of the Cerebral Circulation in
`Children ; Normal Values for Cerebral Blood Flow and Cerebral Metabolic Rate in Child-
`hood. CHARLES KENNEDY AND LOUIS SoKOLOFF . . . ....... .... ... .... . . .. .. .. .... . . 1130
`Response of Pulmonary Artery Pressure and Total Pulmonary Resistance of Untrained,
`Convalescent Man to Prolonged Mild Steady State Exercise. SALVATORE M. SANCETTA
`AND Lours RAKITA ... . ..... . .......... . ........ . ..... . ............. .. .. . ....... 1138
`Idiopathic Pulmonary Hemosiderosis. A Study of the Anemia and Iron Distribution Using
`Radioiron and Radiochromium. LEONARD APT, MYRON PoLLYCOVE, AND JOSEPH
`F.Ross . . . . ... . ....... . .... . ............ . . . ... . . . . . ... .... .... . ...... . ........ 1150
`Studies on the Immunochemical Basis of Allergic Reactions to Dextran in Man. ELVIN A.
`KABAT, GERARD M. TURINO, ARTHUR B. TARROW, AND PAUL H. MAURER ............. 1160
`Effects of Eight-Hour Intravenous Infusions of ACTH and the Adrenocortical Steroids in
`I. Basal Gastric Secretion, and Plasma and Urinary Pepsinogen. B. I.
`Normal M a n.
`H!RSCHOWITZ, 0. H.P. STREETEN, J. A. LONDON, AND H. M. POLLARD .... .. ........ . 1171
`Study of Urinary and Fecal Excretion of Radioactive Chromium Cr51 in Man.
`Its Use in the
`Measurement of Intestinal Blood Loss Associated with Hookworm Infection. MARCEL
`ROCHE, M ARIA E NRIQUETA PEREZ-GIMENEZ, MIGUEL LAYRJSSE, AND ESTELA D1 PRISCO. 1183
`
`NUMBER 8, AUGUST, 1957
`
`Exchange of Ceruloplasmin Copper With Ionic CUM With Reference to Wilson's Disease.
`I. HERBERT SCHEINBERG AND ANATOL G. MORELL... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1193
`JACK D. ROSENBAUM,
`The Influence of Ethanol Upon Maintained Water Diuresis in Man.
`SoLOMON PAPPER, HENRY W. COHEN, AND REGINA McLEAN .. . .. .. . ....... . ......... 1202
`Studies on Copper Metabolism. XXIII. Portal (Laennec's) Cirrhosis of the Liver. C. J.
`GUBLER, H. BROWN, H. MARKOWITZ, G. E. CARTWRIGHT, AND M. M. WINTROBE ... . .. 1208
`The Distribution and Excretion of Phenobarbital. WILLIAM J. WADDELL AND THOMAS
`C. BUTLER ........ . . .... .......... . ......... . ....... ...... .. . ..... . .. .. ... .... 1217
`Apparent Free Amino Acids in Deproteinized Plasma of Normal and Uremic Persons. PETER
`F. SALISBURY, MAX S. DUNN, AND EDWARD A. MURPHY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1227
`Further Observations on the Hemodynamic Effect of Plasma Volume Expansion by Dextran.
`]. W. FLEMING AND W. L. BLOOM ............. . .................... . ............. 1233
`I. The Method of
`Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders.
`Analysis and the Values in Normal Muscle. BENJAMIN A. BARNES, ESTHER B. GORDON,
`AND OLIVER COPE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1239
`Cation Accumulation by Muscle Tissue: The Displacement of Potassium by Rubidium and
`Cesium in the Living Animal. ARNOLDS. RELMAN, ANNE T. LAMBIE, BELTON A. BUR-
`ROWS, AND ARLENE M. Roy ... . . ....... . . . . . ...... .............................. 1249
`
`

`

`CONTENTS
`
`IX
`
`Porto-Cava! and Porto-Pulmonary Anastomoses in Laennec's Cirrhosis and in Heart Failurt.
`PAUL CALABRESI AND WALTER H. ADELMANN ..... . .. .. . . .................. ...•.••. 1257
`Studies on Phenolic Steroids in Huma n Subjects.
`II. The Metabolic Fate and llcpato-Bilinry•
`Enteric Circulation of C 14-Estrone and C14-Estradiol in Women. AVERY A. SANDDPRG
`AND W. RoY SLAUNWHITE, JR ...... ..... . ..... ... .... ...... .. .. .........•..•.•.• 1266
`Pathways of Glycogen Formation in Liver and Skeletal Muscle in Fed and Fasted Rats.
`. . , . . . . 1279
`PAUL A. MARKS AND PHIUP FEIGELSON. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
`.
`The Effect of Histamine on Skin and Deep Temperatures in Man With Particular Reference to
`. . • . . • . 1285
`Liver Temperature.
`\\7. GRAF. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
`
`1301
`
`NUMBER 9, SEPTEMBER, 1957
`Depletion of Carcass Potassium in Rats Made Hypertensive With Desoxycorticosterone
`Acetate (DCA) and With Cortisone. ABBIE I. KNOWLTON AND EMrLY N. LOEB ...... 1295
`The Physiological Disposition and Metabolic Fate of Cortisone in Man. RALPH E. PETERS0:-1,
`CHARLES E. PIERCE, JAMES B. WYNGAARDEN, JOSEPH J. BUNIM, AND BERNARD
`B. BRODIE... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
`Thyroid-Adrenocortical Interrelations: Failure to Demonstrate Antagonism Between Tri(cid:173)
`iodothyronine and Hydrocortisone in Man. KENNETH FREMONT-SMITH, FRANKL. IBP.R,
`AND IRVIN C. PLOUGH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... 1313
`The Influence of Autonomic Vasoregulatory Reflexes on the Rate of Sodium and Water
`Excretion in Man. HENRY N. WAGNER, JR ..... .. .. . ... . .......... . .......... .... 1319
`Acid Mucopolysaccharides in Normal Serum. ALFRED JAY BOLLET, MARIA W. SERAYDARJAN,
`AND WILLIAM F. SIMPSON. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1328
`Thyroxine-Binding by Serum and Urine Proteins in Nephrosis. Qualitative Aspects. JACOB
`ROBBINS, J. E. RALL, AND MARY L. PETERMANN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1333
`A Comparison of the Phenylalanine Content of the Hemoglobin of Normal and Phenylketonuric
`Individuals: Determination by Ion Exchange Chromatography. DAVID W. ALLEN AND
`w. A. SCHROEDER ........................................ . ............... ...... 1343
`Physiological Disposition of 4-C1•-Cortisol During Late Pregnancy. CLAUDE J. MrGEON,
`JEAN BERTRAND,AND PATRICIA E. WALL . . ............. ...... ...... . .............. 1350
`A Simple Nephelometric Method for the Determination of Human Serum Beta-Lipoprotein.
`PETER BERNFELD, MORDECAI E. BERKOWITZ, AND VIRGINIA M. DONAHUE ... .......... 1363
`Influence of Cortisone and Prednisolone in Hyperbilirubinemia. RICARDO KATZ, HECTOR
`Ducci, AND HERNAN ALESSANDRI ........................................... .... 1370
`The Relationship of Total Exchangeable Potassium and Chloride to Lean Body Mass, Red Cell
`Mass and Creatinine Excretion in Man. F. P. MULDOWNEY, J. CROOKS, AND M. M.
`BLUHM .............................................. , ............... . ......... 1375
`
`NUMBER 10, OCTOBER, 1957
`The Effect of Insulin on Blood Levels of Infused Pentoses in Man. STANTON SEGAL, JAMES
`B. WYNG.AARDEN, AND JOSEPH FOLEY . .......... ... ........................... . ... 1383
`Physiological Disposition and Metabolic Fate of Infused Pentoses in Man.
`JAMES B. WYN-
`GAARDEN, STANTON SEGAL, AND JOSEPH B. FOLEY ........................... ...... , 1395
`I. The Pathway of K ucleic Acid Ribose Synthesis in a Human
`Studies of Ribose Metabolism.
`Carcinoma Cell in Tissue Culture. How ARD H. HIATT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1408
`Production of Hypertonic Urine in the Absence of Pituitary Antidiuretic Hormone. ROBERT
`W. BERLINER AND DOUGLAS G. DAVIDSON .. . .............................. ....... . 1416
`The Destruction of Red Cells by Antibodies in Man.
`I. Observations on the Sequestration
`and Lysis of Red Cells Altered by Immune Mechanisms. }AMES H. JANDL, A. RICHARD-
`SON JONES, AND WILLIAM B. CASTLE .................. . ........................... 1428
`
`

`

`X
`
`CONTENTS
`
`I. Studies in Non-Medically
`Electrolyte and Water Excretion in Arterial Hypertension.
`Treated Subjects with Essential Hypertension. WILLIAM Hou.ANDER AND WALTER
`E. JUDSON ......... . .................................... .. ...... ..... .......... 1460
`Radioactivity Over the Spleen and Liver Following the Transfusion of Chromium61-Labelled
`Erythrocytes in Hemolytic Anemia. LEE L. SCHLOESSER, DONALD R. KORST, DALLAS
`V. CLATANOFF, AND ROBERT F. ScHILLING ............................ . ............ 1470
`I. Differences in Different States of
`The Thyroid Hormone-Plasma Protein Complex in Man.
`Thyroid Function. MILTON w. HAMOLSKY, HASKELL E. ELLISON, AND A. STONE FREED-
`BERG ....... . ....................... ... .... .. ....... . ............ . ............. 1486
`The Effects of Nucleosides on the Resistance of Normal Human Erythrocytes to Osmotic
`. Lysis. ERNST R. JAFFE, BERTRAM A. LOWY, GRACE A. VANDERHOFF, PHILIP A. AISEN,
`AND IRVING M. LONDON ................ . ............... ........ ................. 1498
`Overproduction of Uric Acid as the Cause of Hyperuricemia in Primary Gout. JAMES B.
`WYNGAARDEN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1508
`Urinary Excretion of Acid Mucopolysaccharides by Patients with Rheumatoid Arthritis.
`NICOLA DI FERRANTE ............................................. . ............. 1516
`Studies of Intestinal Digestion and Absorption in the Human. B. BORGSTROM, A. DAHLQVIST,
`G. LUNDH, AND J. SJ0VALL ..... ........... ............. .. ....................... 1521
`
`NUMBER 11, NOVEMBER, 1957
`
`General Hemodynamics and Splanchnic Circulation in Patients with Coarctation of the Aorta.
`]AMES W. CULBERTSON, JOHN W. ECKSTEIN, WALTER M. KIRKENDALL, AND GEORGE
`N. BEDELL ............................ . ....................................... 1537
`The Potentiation of Exogenous Insulin by Tolbutamide in Depancreatized Dogs. RAYMOND
`CAREN AND L