Todd L. Lowary, Curriculum Vitae
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`Address:
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`Dr. Todd L. Lowary
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`Department of Chemistry
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`University of Alberta
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`Gunning-Lemieux Chemistry Centre
`11227 Saskatchewan Drive
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`Edmonton, Alberta T6G 2G2 Canada
`Phone: 1-780-492-1861
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`tlowary@ualberta.ca
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`www.lowarylab.ca
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`February 2, 1966
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`Institute of Biological Chemistry
`Academia Sinica
`Academia Road, Section 2, #128
`Nangang, Taipei, 11529
`Taiwan
`Phone: 886-2-2785-5696 Ext 2050
`tlowary@gate.sinica.edu.tw
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`Birthdate:
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`Citizenship: Dual Citizen, Canada and United States of America
`Taiwan Alien Resident Card Holder
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`Education: B.A., Chemistry, with highest honors, June 1988
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`University of Montana
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`Ph.D., Chemistry, July 1993
`University of Alberta
`Thesis Title: Recognition of Synthetic Oligosaccharides by the Blood Group A, B
`and H Gene-Specified Glycosyltransferases
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`Research Positions:
`1995–1996
`Post-Doctoral Research Fellow, Department of Chemistry, Carlsberg Laboratory,
`Copenhagen, Denmark with Dr. Klaus Bock
`Post-Doctoral Research Fellow, Department of Chemistry, University of Alberta
`with Dr. David R. Bundle
`1989–1993 Graduate Student, Department of Chemistry, University of Alberta with Dr. Ole
`Hindsgaul
`Laboratory Technician, Wood Chemistry Laboratory, University of Montana with Dr.
`Geoffrey N. Richards
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`1993–1995
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`1988–1989
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`Professional Positions:
`January 2020–Present
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`July 2019–Present
`September 2015–Present
`October 2014–June 2019
`July 2006–Present
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`July 2003–June 2006
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`Joint Appointment Professor, Institute of Biochemical
`Sciences, National Taiwan University
`Distinguished Research Fellow, Academia Sinica
`R. U. Lemieux Chair in Carbohydrate Chemistry
`Canada Research Chair in Carbohydrate Chemistry (Tier 1)
`Professor, University of Alberta
`Associate Professor, University of Alberta
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`Todd L. Lowary, Curriculum Vitae
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`October 2002–June 2003
`October 1996–September 2002
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`Administrative Positions:
`July 2019–Present
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`July 2018–Present
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`November 2014–Present
`January 2012–March 2015
`January 2013–March 2014
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`January 2009–December 2011
`July 2009–June 2011
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`July 2006–June 2011
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`Associate Professor, The Ohio State University
`Assistant Professor, The Ohio State University
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`Director, Institute of Biological Chemistry, Academia Sinica
`Chair, Division of Organic Chemistry, University of Alberta,
`Department of Chemistry
`Scientific Director, Canadian Glycomics Network (NCE)
`Scientific Director, Alberta Glycomics Centre
`Associate Chair, Graduate Studies, University of Alberta,
`Department of Chemistry
`Associate Director, Science, Alberta Glycomics Centre
`Associate Chair, Graduate Studies, University of Alberta,
`Department of Chemistry
`Chair, Division of Organic Chemistry, University of Alberta,
`Department of Chemistry
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`Carbohydrate Research
`Advances in Carbohydrate Chemistry and Biochemistry
`ChemistryOpen
`Frontiers in Chemical Biology
`Journal of Biological Chemistry
`Journal of the Chinese Chemical Society
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`Editor, Carbohydrate Research
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`Editorial Boards:
`January 1997–December 2016
`January 2010–December 2015
`January 2011–Present
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`November 2013–Present
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`July 2014–Present
`January 2018–Present
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`Editorial Positions:
`January 2004–December 2016
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`Advisory Boards:
`2013–2021
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`2012–2015
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`2012–2014
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`Honors and Awards:
`2020
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`Arthur C. Cope Scholar Award of the American Chemical Society
`2019
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`Alfred Bader Award of the Canadian Society for Chemistry
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`Max Planck Institute of Colloids and Interfaces Scientific Advisory Board
`Berlin Glycan Forum Scientific Advisory Board
`27th International Carbohydrate Symposium International Advisory Board
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`Todd L. Lowary, Curriculum Vitae
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`University Cup (University of Alberta)
`J. Gordin Kaplan Award for Excellence in Research (University of Alberta)
`Visiting Professor, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
`ASTech Outstanding Leadership in Alberta Science Award
`Instructor Appreciation Night Award from the Interdepartmental Science Students
`Society (teaching award)
`Melville L. Wolfrom Award, Division of Carbohydrate Chemistry of the American
`Chemical Society
`University of Alberta Killam Annual Professorship
`Rutherford Award for Excellence in Undergraduate Teaching
`Bernard Belleau Award of the Canadian Society for Chemistry
`Chinese Academy of Sciences Visiting Professorship
`Brockhouse Canada Prize for Interdisciplinary Research in Science and Engineering
`(with D. R. Bundle, G. A. Armstrong, J. S. Klassen and K. K. S. Ng)
`Elected Fellow of the American Chemical Society
`Faculty of Science Award for Excellent Teaching
`Elected Fellow of the American Association for the Advancement of Science
`Richard E. Juday Lecturer, Department of Chemistry, University of Montana
`Co-Chair of Carbohydrates Gordon Conference
`Carbohydrate Research Award for Creativity in Carbohydrate Chemistry
`E. W. R. Steacie Memorial Fellowship
`Fellowship for Foreign Distinguished Scholars, National Science Council, Taiwan
`Chemistry Students Association Teaching Excellence Award
`Horace S. Isbell Award, Division of Carbohydrate Chemistry of the American
`Chemical Society
`Ohio State University Alumni Award for Distinguished Teaching
`Presidential Early Career Award for Scientists and Engineers (PECASE)
`Alberta Heritage Foundation for Medical Research Post-Doctoral Fellowship
`University of Alberta Mary Louise Imrie Graduate Scholarship
`Graduate Teaching Award for Outstanding Undergraduate Teaching
`President, University of Alberta Organic Chemistry Division Graduate Students
`Alberta Heritage Foundation for Medical Research Graduate Scholarship
`University of Alberta Walter H. Johns Graduate Scholarship
`University of Montana Watkins Senior Thesis Scholarship
`Fred Shafizadeh Memorial Scholarship
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`2017
`2016
`2016
`2015
`2014
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`2013
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`2012
`2012
`2012
`2011
`2011
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`2011
`2011
`2010
`2008
`2007
`2007
`2006
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`2005
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`1999
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`1999
`1994–1995
`1992–1993
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`1991–1992
`1990–1993
`1989–1990
`1987–1988
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`Todd L. Lowary, Curriculum Vitae
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`University of Montana Chemistry-Alumni Faculty Award
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`American Institute of Chemists Student Award
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`Sigma Xi Award for Outstanding Senior Science Student
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`University of Montana Outstanding Senior in Chemistry
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`Montana ACS Best Undergraduate Presentation Award
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`University of Montana Fox Foundation Scholarship
`1986–1987
`University of Montana Sophomore Honors Scholarship
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`University of Montana Fox Foundation Scholarship
`1985–1986
`1984–1985 University of Montana Fox Foundation Scholarship
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`Montana High School Valedictorian Fee Waiver
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`Publication/Citation Metrics (May 2, 2020):
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`Lifetime Citations: 6013 (Web of Science); 7858 (Google Scholar)
`h-index: 43 (Science Citation Index); 49 (Google Scholar)
`ResearcherID: F-9608-2019
`ORCID: 0000-0002-8331-8211
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`Publications (As a student or postdoctoral fellow):
`Lowary, T. L.; Richards, G. N. “Effects of Impurities on the Hydrolysis of Sucrose in
`1.
`Concentrated Aqueous Solution” Int. Sugar J. 1988, 90, 164–167.
`Lowary, T. L.; Richards, G. N. “Vacuum Pyrolysis of Bark from Pinus ponderosa” J.
`Wood Chem. and Tech. 1988, 8, 393–412.
`Essig, M.; Lowary, T. L.; Richards, G. N.; Schenck, E. “Influences of ‘Neutral’ Salts on
`Thermochemical Conversion of Cellulose and Sucrose” Proceedings from: Research in
`Thermochemical Biomass Conversion, an International Conference, Phoenix, May 1988.
`Lowary, T. L.; Richards, G. N. “Analysis of a Hydroxystilbene Glucoside in Several
`Softwood Barks” J. Wood Chem. and Tech. 1989, 9, 333–340.
`Lowary, T. L.; Richards, G. N. “Mechanisms of Pyrolysis of Polysaccharides: Cellobiitol
`as a Model for Cellulose” Carbohydr. Res. 1990, 198, 79–89.
`Lowary, T. L.; Richards, G. N. “Cycloheptaamylose as a Model for Starch in the
`Pyrolysis of Polysaccharides” Carbohydr. Res. 1991, 218, 157–166.
`Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic Deoxy and Deoxyfluoro
`Analogs of the Acceptor a-L-Fucp-(1®2)-b-D-Galp-OR by the Blood-Group A and B
`Gene-Specified Glycosyltransferases” Carbohydr. Res. 1993, 249, 163–195.
`Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic O-methyl, Epimeric and Amino
`Analogs of the Acceptor a-L-Fucp-(1®2)-b-D-Galp-OR by the Blood-Group A and B
`Gene-Specified Glycosyltransferases” Carbohydr. Res. 1994, 251, 33–67.
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`Lowary, T. L.; Swiedler, S. J.; Hindsgaul, O. “Recognition of Synthetic Analogs of the
`Acceptor b-D-Galp-OR by the Blood-Group H Gene-Specified Glycosyltransferase”
`Carbohydr. Res. 1994, 256, 257–273.
`Lowary, T. L.; Bundle, D. R. “Nucleophile Induced Rearrangements of Thioglycosides:
`Formation of 6-Thio Glycosides and 1,6 Thioanhydrosugars” Tetrahedron: Asymmetry
`1994, 12, 2397–2404.
`11. Deng, S-j.; McKenzie, C. R.; Hirama, T.; Brousseau, R.; Young, N. M.; Lowary, T. L.; Bundle,
`D. R.; Narang, S. A. “Basis for Selection of Improved Carbohydrate-Binding Single-
`Chain Antibodies from Synthetic Gene Libraries” Proc. Natl. Acad. Sci. USA 1995, 92,
`4992–4996.
`Lowary, T. L.; Eichler, E.; Bundle, D. R. “Synthesis of a Pentasaccharide Epitope for the
`Investigation of Carbohydrate-Protein Interactions” J. Org. Chem. 1995, 60, 7316–7327.
`Peters, S.; Lowary, T. L.; Hindsgaul, O.; Meldal, M.; Bock, K. “Solid Phase Synthesis of a
`Fucosylated Glycopeptide of Human Factor IX with a Fucose-a-(1®O)-Serine
`Linkage” J. Chem. Soc. Perkin Trans. 1 1995, 3017–3022.
`14. Greis, K. D.; Hayes, B. K.; Comer, F. I.; Kirk, M.; Barnes, S.; Lowary, T. L.; Hart, G. W.
`“Selective Detection of Glycopeptides and Site Mapping by Electrospray Mass
`Spectrometry” Anal. Biochem. 1996, 234, 38–49.
`St. Hilaire, P.; Lowary, T.; Meldal, M.; Bock, K. “Synthesis and Analysis of Glycopeptide
`Libraries and Their Application in Solid Phase Assays of Carbohydrate Binding
`Proteins” in Peptides 1996, Proceedings of the 24th European Peptide Symposium,
`Edinburgh, Scotland, September 8–13, 1996; Ranage, R, Epton, R Eds. 1998, pages 817–818.
`Lowary, T. L.; Meldal, M. Helmboldt, A.; Vasella, A.; Bock, K. “Novel Rigid Type of C-
`linked Glycosylacetylene Phenylalanine Building Blocks for Combinatorial Syntheses
`of C-Linked Glycopeptides” J. Org. Chem. 1998, 63, 9657–9668.
`St. Hilaire, P. M.; Lowary, T. L.; Meldal, M.; Bock, K. “Oligosaccharide Mimetics
`Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded Glycopeptide
`Libraries” J. Am. Chem. Soc. 1998, 120, 13312–13320.
`Laferté, S.; Chan, N. W. C.; Sujino, K.; Lowary, T. L.; Palcic, M. M. “Intracellular
`Inhibition of Blood Group A Glycosyltransferase” Eur. J. Biochem. 2000, 267, 4840–4849.
`Lowary, T. L.; Eichler, E., Bundle, D. R. "Oligosaccharide Recognition by Antibodies:
`Synthesis and Evaluation of Talose Oligosaccharide Analogues" Can. J. Chem. 2002, 80,
`1112–1130.
`Harrison, J. A.; Ravindranathan Kartha, K. P.; Fournier, E. J. L.; Lowary, T. L.; Malet, C.;
`Nilsson, U. J.; Hindsgaul, O.; Schenkman, S.; Naismith, J. H.; Field, R. A. “Probing the
`Acceptor Substrate Binding Site of Trypanosoma cruzi trans-sialidase with
`Systematically Modified Substrates and Glycoside Libraries” Org. Biomol. Chem. 2011, 9,
`1653–1660.
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`Todd L. Lowary, Curriculum Vitae
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`Publications (As a principal investigator; underlined names are individuals supervised by
`TLL):
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`Ayers, J. D.; Lowary*, T. L.; Morehouse, C. B.; Besra, G. S. “Recognition of Synthetic
`Synthetic
`Arabinofuranosyl
`Oligosaccharides
`by
`Mycobacterial
`Arabinosyltransferases” Bioorg. Med. Chem. Lett. 1998, 8, 437–442.
`D’Souza, F. W.; Lowary*, T. L. “A New Route to Carbohydrates Enriched with Oxygen
`Isotopes” J. Org. Chem. 1998, 63, 3166–3167.
`Bausch, C.; Peekhaus, N.; Utz, C.; Blais, T.; Murray, E.; Lowary, T. L.; Conway*, T.
`“Sequence Analysis of the GntII (Subsidiary) System for Gluconate Metabolism
`Reveals a Novel Pathway for L-Idonic Acid Catabolism in E. coli” J. Bacteriol. 1998, 180,
`3704–3710.
`D’Souza, F. W.; Cheshev, P. E.; Ayers, J. D.; Lowary*, T. L. “Conversion of Pyranose
`Glycals to Furanose Derivatives: A New Route to Oligofuranosides” J. Org. Chem. 1998,
`63, 9037–9044.
`Subramaniam, V.; Lowary*, T. L. “Synthesis of Oligosaccharide Fragments of
`Mannosylated Lipoarabinomannan from Mycobacterium tuberculosis” Tetrahedron,
`1999, 55, 5965–5976.
`Gordon, M. T.; Lowary*, T. L.; Hadad*, C. M. “A Computational Study of Methyl a-D-
`Arabinofuranoside: Effect of Ring Conformation on Structural Parameters and
`Energy Profile” J. Am. Chem. Soc. 1999, 121, 9682–9692.
`Callam, C. S.; Lowary*, T. L. “Total Synthesis of Methyl 4a-carba-D-
`arabinofuranosides” Org. Lett. 2000, 2, 167–169.
`Davis, T. M.; Lowary*, T. L. “Unexpected Formation of Glycals Upon Attempted C-
`alkylation of Protected Glycosylacetylenes” Carbohydr. Res. 2000, 324, 210–217.
`D’Souza, F. W.; Ayers, J. D.; McCarren, P. R.; Lowary*, T. L. “Arabinofuranosyl
`Oligosaccharides from Mycobacteria: Synthesis and Effect of Glycosylation on Ring
`Conformation and Hydroxymethyl Group Rotamer Populations” J. Am. Chem. Soc.
`2000, 122, 1251–1260.
`D’Souza, F. W.; Lowary*, T. L. “The First Total Synthesis of a Highly Branched
`Arabinofuranosyl Hexasaccharide Found at
`the Nonreducing Termini of
`Mycobacterial Arabinogalactan and Lipoarabinomannan” Org. Lett. 2000, 2, 1493–1495.
`Chang, G. X.; Lowary*, T. L. “A Glycosylation Protocol Based on Activation of
`Glycosyl 2-Pyridyl Sulfones with Samarium Triflate” Org. Lett. 2000, 2, 1505–1508.
`Gordon, M. T.; Lowary*, T. L.; Hadad*, C. M. “Probing Furanose Ring Conformation
`by Gas-Phase Computational Methods: Energy Profile and Structural Parameters in
`Methyl b-D-arabinofuranoside as a Function of Ring Conformation” J. Org. Chem. 2000,
`65, 4954–4963.
`Callam, C. S.; Gadikota, R. R.; Lowary*, T. L. “An Efficient Synthesis of Methyl 2,3-
`Anhydro-a-D-ribofuranoside” Carbohydr. Res. 2001, 330, 267–270.
`Callam, C. S.; Lowary*, T. L. “Synthesis of Methyl 2,3,5-tri-O-benzoyl-a-D-
`Arabinofuranoside in the Organic Laboratory” J. Chem. Educ. 2001, 78, 73–74.
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`Gadikota, R. R.; Callam, C. S.; Lowary*, T. L. “Stereocontrolled Synthesis of 2,3-
`Anhydro-b-D-lyxofuranosyl Glycosides” Org. Lett. 2001, 3, 607–610.
`16. McGurk, P.; Chang, G. X.; Lowary, T. L.; McNeil, M.; Field*, R. A. “Stereospecific
`Synthesis of 5-Phospho-a-D-arabinosyl-C-phosphonophosphate (pACpp): A Stable
`Analogue of the Putative Mycobacterial Cell Wall Biosynthetic Intermediate 5-
`Phospho-D-arabinosyl Pyrophosphate” Tetrahedron Lett. 2001, 42, 2231–2234.
`17. McCarren, P. R.; Gordon, M. T.; Lowary*, T. L.; Hadad*, C. M. “Computational Studies
`of the Arabinofuranose Ring: Conformational Preferences of Fully Relaxed Methyl a-
`D-arabinofuranoside” J. Phys. Chem. A. 2001, 105, 5911–5922.
`Callam, C. S.; Lowary*, T. L. “Suzuki Cross Coupling Reactions: Synthesis of
`Unsymmetrical Biaryls in the Organic Laboratory” J. Chem. Educ. 2001, 78, 947–948.
`Callam, C. S.; Gadikota, R. R.; Lowary*, T. L. “Sensitivity of 1JC1-H1 Magnitudes to
`Anomeric Stereochemistry in 2,3-Anhydro-O-furanosides” J. Org. Chem. 2001, 66, 4549–
`4558.
`Yin, H. F.; Lowary*, T. L. “Synthesis of Arabinofuranosides via Low-Temperature
`Activation of Thioglycosides” Tetrahedron Lett. 2001, 42, 5829–5832.
`Houseknecht, J. B.; McCarren, P. R.; Lowary*, T. L.; Hadad*, C. M. “Conformational
`Studies of Methyl 3-O-Methyl-a-D-Arabinofuranoside: An Approach for Studying the
`Conformation of Furanose Rings” J. Am. Chem. Soc. 2001, 123, 8811–8824.
`Callam, C. S.; Singer, S. J.; Lowary*, T. L.; Hadad*, C. M. “Computational Analysis of the
`Potential Energy Surfaces of Glycerol in the Gas and Aqueous Phases. Effects of
`Level of Theory and Basis Set on Strongly Intramolecular Hydrogen-Bonded
`Systems” J. Am. Chem. Soc. 2001, 123, 11743–11754.
`Callam, C. S.; Lowary*, T. L. “Synthesis and Conformational Investigations of Methyl
`4a-carba-D-arabinofuranosides” J. Org. Chem. 2001, 66, 8961–8972.
`Gadikota, R. R.; Callam, C. S.; Lowary*, T. L. “Total Synthesis of (2S,3S,5S,10S)-6,9-
`epoxynonadec-18-ene-7,10-diol and Formal Total Synthesis of (+)-trans-Kumausyne
`from D-Arabinose” J. Org. Chem. 2001, 66, 9046–9051.
`Yin, H.; D’Souza, F. W.; Lowary*, T. L. “Arabinofuranosides from Mycobacteria:
`Synthesis of a Highly Branched Hexasaccharide and Related Fragments Containing
`b-Arabinofuranosyl Residues” J. Org. Chem. 2002, 67, 892–903.
`Houseknecht, J. B.; Lowary*, T. L. “Oligofuranosides Containing Conformationally-
`Restricted Residues: Synthesis and Conformational Analysis” J. Org. Chem. 2002, 67,
`4150–4164.
`Houseknecht, J. B.; Altona, C.; Hadad, C. M.; Lowary*, T. L. “Conformational Analysis of
`Furanose Rings with PSEUROT: Parameterization for Rings Possessing the
`Arabino-, Lyxo-, Ribo- and Xylo- Stereochemistry and Application
`to
`Arabinofuranosides” J. Org. Chem. 2002, 67, 4647–4651.
`Krein, D. M.; Lowary*, T. L. “An Efficient Route to 2-(Alkylamino)pyridines” J. Org.
`Chem. 2002, 67, 4965–4967.
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`Kaur, D.; Lowary, T. L.; Vissa, V. D.; Crick, D. C.; Brennan*, P. J. "Characterization of the
`Epitope
`of
`Anti-lipoarabinomannan
`Antibodies
`as
`the
`Terminal
`Hexaarabinofuranosyl Motif of Mycobacterial Arabinans" Microbiology UK, 2002, 148,
`3059–3067.
`Basak, P.; Lowary*, T. L.; “Synthesis of Conjugates of L-Fucose and ortho-Carborane
`as Potential Agents for Boron Neutron Capture Therapy” Can. J. Chem. 2002, 80, 943–
`948.
`Centrone, C. A.; Lowary*, T. L. “Synthesis and Anti-tuberculosis Activity of C-
`Phosphonate Analogs of Decaprenolphosphoarabinose, A Key Intermediate in the
`Biosynthesis of Mycobacterial Arabinogalactan and Lipoarabinomannan” J. Org. Chem.
`2002, 67, 8862–8870.
`Houseknecht, J. B.; Lowary*, T. L.; Hadad*, C. M. “Improved Karplus Equations for
`3JC1,H4 in Aldopentofuranosides. Application to the Conformational Preferences of the
`Methyl Aldopentofuranosides” J. Phys. Chem. A. 2003, 107, 372–378.
`Han, J.; Gadikota, R. R.; McCarren, P. R.; Lowary*, T. L. “Synthesis of Octyl
`Arabinofuranosides as Substrates for Mycobacterial Arabinosyltransferases Carbohydr.
`Res. 2003, 338, 581–588.
`Gadikota, R. R.; Keller, A. I.; Callam, C. S.; Lowary*, T. L. “Efficient Syntheses of trans-
`(+)-Laurediol from Carbohydrate Precursors” Tetrahedron: Asymm. 2003, 14, 737–742.
`Gadikota, R. R.; Callam, C. S.; Appelmelk, B. J.; Lowary*, T. L. “Synthesis of
`Oligosaccharide Fragments of Mannosylated Lipoarabinomannan Appropriately
`Functionalized for Neoglycoconjugate Preparation” J. Carbohydr. Chem. 2003, 22, 459–
`480.
`Gadikota, R. R.; Callam, C. S.; Wagner, T.; Del Fraino, B.; Lowary*, T. L. “2,3-
`Anhydrosugars in Glycoside Bond Synthesis. Highly Stereocontrolled Synthesis of
`Oligosaccharides Containing a- and b-Arabinofuranosyl Linkages” J. Am. Chem. Soc.
`2003, 125, 4155–4165.
`Han, J.; Lowary,* T. L. “Total Synthesis of Buergerinin F and Buergerinin G” J. Org.
`Chem. 2003, 68, 4116–4119.
`Callam, C. S.; Gadikota, R. R.; Lowary*, T. L. “An Efficient Route to Pyrimidine
`Nucleosides with the 2,3-Anhydro-b-D-lyxofuranosyl Stereochemistry” Synlett, 2003,
`1271–1274.
`Houseknecht, J. B.; Lowary*, T. L.; Hadad*, C. M. “Gas and Solution Phase Energetics
`of the Methyl a- and b-D-aldopentofuranosides” J. Phys. Chem. A. 2003, 107, 5763–5777.
`Centrone, C. A.; Lowary*, T. L. “An Efficient Route for the Synthesis of Glycosyl
`Phosphinic Acids” J. Org. Chem. 2003, 68, 8115–8119.
`Callam, C. S.; Gadikota, R. R.; Krein, D. M.; Lowary*, T. L. “2,3-Anhydrosugars in
`Glycoside Bond Synthesis. NMR and Computational Investigations into the
`Mechanism of Glycosylations with 2,3-Anhydrofuranosyl Glycosyl Sulfoxides” J. Am.
`Chem. Soc. 2003, 125, 13112–13119.
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`Todd L. Lowary, Curriculum Vitae
`
`Darwish, O.; Callam, C. S.; Hadad. C. M.; Lowary*, T. L. “Regioselectivity in Alkylation
`Reactions of 1,2-O-Stannylene Acetals of D-Arabinofuranose” J. Carbohydr. Chem. 2003,
`22, 963–981.
`Cociorva, O. M.; Lowary*, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis.
`Application to the Preparation of C–2 Functionalized a-D-Arabinofuranosides”
`Tetrahedron 2004, 60, 1481–1489.
`Cociorva, O. M.; Lowary*, T. L. “Synthesis of Oligosaccharides as Potential Inhibitors
`of Mycobacterial Arabinosyltransferases. Di- and Trisaccharides Containing C-5
`Modified Arabinofuranosyl Residues” Carbohydr. Res. 2004, 339, 853–865.
`Centrone, C. A.; Lowary*, T. L. “Sulfone and Phosphinic Acid Analogs of
`Decaprenolphosphoarabinose as Potential Anti-tuberculosis Agents” Bioorg. Med. Chem.
`2004, 12, 5495–5503.
`Koppel. E. A.; Ludwig, I. S.; Sanchez-Hernandez, M.; Lowary, T. L.; Gadikota, R. R.; Bovin,
`N.; Vandenbroucke, C. M. J. E, van Looyk, Y.; Appelmelk, B. J.; Geijtenbeek*, T. B. H.
`“Identification of the Mycobacterial Carbohydrate Structure That Binds the C-type
`Lectins DC-SIGN, L-SIGN and SIGNR1” Immunobiol. 2004, 209, 117–127.
`Tilekar, J. N.; Lowary*, T. L. “An Efficient Route to Thioglycosides with the 2,3-
`Anhydro-D-ribo Stereochemistry” Carbohydr. Res. 2004, 339, 2895–2899.
`Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary*, T. L. “Modified Mannose
`Disaccharides as Substrates and Inhibitors of a Polyprenol Monophosphomannose-
`Dependent
`a-(1®6)-Mannosyltransferase
`Involved
`in Mycobacterial
`Lipoarabinomannan Biosynthesis” Bioorg. Med. Chem. 2005, 13, 1083–1094.
`Cociorva, O. M.; Gurcha, S. S.; Besra, G. S.; Lowary*, T. L. “Oligosaccharides as
`Inhibitors of Mycobacterial Arabinosyltransferases.
` Di- and Trisaccharides
`Containing C-3 Modified Arabinofuranosyl Residues” Bioorg. Med. Chem. 2005, 13,
`1369–1379.
`Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary*, T. L. “Synthetic Disaccharide
`Analogs as Potential Substrates and Inhibitors of a Mycobacterial Polyprenol
`Monophosphomannose-Dependent a-(1®6)-Mannosyltransferase” Tetrahedron Asymm.
`2005, 15, 553–567.
`Completo, G. C.; Ponto, J. A.; Lowary*, T. L. “Synthesis of Oligosaccharide Fragments
`of the Lipoarabinomannan from Rhodocuccus ruber” J. Carbohydr. Chem. 2005, 24, 517–
`527.
`Tong, M.; Jacobi, C. E.; van de Rijke, F. M.; Kuijper, S.; van de Werken, S.; Lowary, T. L.;
`Hokke, C. H.; Appelmelk, B. J.; Nagelkerke, N. J. D.; Tanke, H. J.; van Gijlswijk, R. P. M.;
`Kolk*, A. H. J.; Raap*, A. K. “A Multiplexed and Miniaturized Serological
`Tuberculosis (TB) Assay Identifies Antigens that Discriminate Maximally Between
`TB and Non-TB Sera” J. Immunol. Meth. 2005, 301, 154–163.
`Luu, T.; Shi, W.; Lowary*, T. L.; Tykwinski*, R. R. “A Divergent Synthesis of Triyne
`Natural Products and Glycosylated Analogues Using a Carbenoid Rearrangement”
`Synthesis 2005, 3167–3178.
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`Todd L. Lowary, Curriculum Vitae
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`Ridgway, K. M.; Shi, W.; Lin, S.-J.; Palcic, M. M.; Lowary*, T. L. “Chemical and
`Chemoenzymatic Synthesis of a Trisaccharide Fragment of Tsukamurella
`paurometabola Lipoarabinomannan” Can J. Chem. 2006, 84, 642–649. (Special Issue in
`Honor of the 65th Birthday of Walter A. Szarek, Queens University)
`Joe, M.; Sun, D.; Taha, H.; Completo, G. C.; Croudace, J. E.; Lammas, D. A.; Besra, G. S.;
`Lowary*, T. L. “The 5-Deoxy-5-Methylthio-Xylofuranose Residue in Mycobacterial
`Lipoarabinomannan.
` Absolute Stereochemistry, Linkage Position, Ring
`Conformation and Immunomodulatory Activity” J. Am. Chem. Soc. 2006, 128, 5059–5072.
`Rose, N. L.; Completo, G. C.; Lin, S.-J.; McNeil, M. R.; Palcic*, M. M.; Lowary*, T. L.
`“Expression, Purification and Characterization of a Galactofuranosyl-transferase
`Involved in Mycobacterium tuberculosis Arabinogalactan Biosynthesis” J. Am. Chem.
`Soc. 2006, 128, 6721–6729.
`Bai, Y.; Lin, S.-J.; Qi, G.; Palcic, M. M.; Lowary, T. L. “Synthesis of n-Octyl 2,6-dideoxy-
`a-L-lyxo-hexopyranosyl-(1®2)-3-amino-3-deoxy-b-D-galactopyranoside, an Analog
`of the H-disaccharide Antigen” Carbohydr. Res. 2006, 341, 1702–1707.
`Chang, G. X.; Lowary*, T. L. “An Olefin Cross Metathesis Approach to C-Disaccharide
`Analogs of the a-D-Arabinofuranosyl-(1®5)-a-D-arabinofuranoside Motif Found in
`the Mycobacterial Cell Wall” Tetrahedron Lett. 2006, 47, 4561–4564.
`59. Mendlik, M. T.; Tao, P.; Hadad, C. M.; Coleman*, R. S.; Lowary*, T. L. “Synthesis of L-
`Daunosamine and L-Ristosamine Glycosides Via Photoinduced Aziridination.
`Conversion to Thioglycosides for Use in Glycosylation Reactions” J. Org. Chem. 2006,
`71, 8059–8070.
`Joe, M.; Lowary*, T. L. “Synthesis of 2-Deoxy-2-fluoro Analogs of Polyprenyl b-D-
`Arabinofuranosyl Phosphates” Carbohydr. Res. 2006, 341, 2723–2730.
`Bai, Y.; Lowary*, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application
`to a-D-Galactofuranosides” J. Org. Chem. 2006, 71, 9658–9671.
`Bai, Y.; Lowary*, T. L. “Synthesis of a Pentasaccharide Fragment of Varianose, a Cell
`Wall Polysaccharide from Penicllium varians” J. Org. Chem. 2006, 71, 9672–9680.
`Sefzik, T.; Houseknecht, J. B.; Clark, T. M.; Prasad, S.; Lowary, T. L.; Gan, Z.; Grandinetti*,
`P. J. “Solid State 17O-NMR in Carbohydrates” Chem. Phys. Lett. 2007, 434, 312–315.
`Fan, E.; Shi, W.; Lowary*, T. L. “Synthesis of Daunorubicin Analogues Containing
`Truncated Aromatic Cores and Unnatural Monosaccharide Residues” J. Org. Chem.
`2007, 72, 2917–2928.
`Voehringer, D.; Stanley, S. A.; Cox, J. S.; Completo, G. C.; Lowary, T. L.; Locksley*, R. M.
`“Identification of Intelectin-1 and -2 as Novel Stat6-dependent Genes Expressed in
`Lung and Intestine During Helminth Infection” Exp. Parasitol. 2007, 116, 458–466.
`Tam, P.-H.; Lowary*, T. L. “Synthesis of a Panel of Deoxy and Methoxy Analogs of the
`a-Manp-(1®6)-a-Manp-O(CH2)7CH3 Acceptor Substrate for a Polyprenolphospho-
`mannose-Dependent Mycobacterial Mannosyltransferase” Carbohydr. Res. 2007, 342,
`1741–1772.
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`Todd L. Lowary, Curriculum Vitae
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`Joe, M.; Bai, Y.; Nacario, R. C.; Lowary*, T. L. “Synthesis of the Docosanasaccharide
`Arabinan Domain of Mycobacterial Arabinogalactan
`and
`a Proposed
`Octadecasaccharide Biosynthetic Precursor” J. Am. Chem. Soc. 2007, 129, 9885–9901.
`Highlighted in Chemical & Engineering News.
`Rademacher, C.; Shoemaker, G. K.; Kim, H.-S.; Zheng, R. B.; Taha, H.; Liu, C.; Nacario, R.
`C.; Schriemer, D. C.; Klassen, J. S.; Peters, T.; Lowary*, T. L. “Ligand Specificity of CS-35,
`a Monoclonal Antibody that Recognizes Mycobacterial Lipoarabinomannan. A
`Model System for Oligofuranoside–Protein Recognition” J. Am. Chem. Soc. 2007, 129,
`10489–10502.
`Hou, D.; Lowary*, T. L. “Stereoselective Synthesis of 2-Deoxy-furanosides from 2,3-
`Anhydro-furanosyl Thioglycosides” Org. Lett. 2007, 9, 4487–4490.
`Liu, C.; Skogman, F.; Cai, Y.; Lowary*, T. L. “Synthesis of the ‘Primer–Adaptor’
`trisaccharide Moiety of Escherichia coli O8, O9 and O9a Lipopolysaccharide”
`Carbohydr. Res. 2007, 342, 2818–2825.
`Tam, P.-H.; Besra, G. S.; Lowary*, T. L. “Exploring the Substrate Specificity of a
`Mycobacterial
`Polyprenol
`Monophosphomannose-dependent
`a-(1®6)-
`mannosyltransferase” ChemBioChem 2008, 9, 267–278.
`Seo, M.; Castillo, N.; Ganzynkowicz, R.; Daniels, C. R.; Woods, R. J.; Roy*, P.-N.; Lowary*,
`T. L. “An Approach for the Simulation and Modeling of Flexible Rings. Application
`to the a-D-arabinofuranoside Ring, a Key Constituent of Polysaccharides from
`Mycobacterium tuberculosis” J. Chem. Theory Comput. 2008, 4, 184–191.
`Appelmelk*, B. J.; den Dunnen, J.; Ummels, R.; Pak, M.; Larrouy-Maumus, G.; Nigou, J.;
`Gurcha, S. S.; Movahedzadeh, F.; Brown, E. J.; Eysink Smeets, M. M.; Besra, G. S.;
`Willemsen, P. T. J.; Lowary, T. L.; van Kooyk, Y.; Maaskant, J. J.; Stoker, N.; Ley, P. v. d.;
`Puzo, G.; Vandenbroucke-Grauls, C. M. J. E.; Wieland, C. W.; van der Poll, T.; Geijtenbeek,
` “The Mannose Cap of Mycobacterial
`T.; van der Sar, A M.; Bitter. W.
`Lipoarabinomannan Does not Dominate the Mycobacterium-host Interaction” Cell.
`Microbiol. 2008, 10, 930–944.
`Belánová, M.; Dianišková, P.; Brennan*, P. J.; Completo, G. C.; Rose, N. L.; Lowary, T. L.;
`Mikušová, K. “Galactosyl Transferases in Mycobacterial Cell Wall Synthesis” J. Bacteriol.
`2008, 190, 1141–1145.
`J.; Lowary*, T. L. “Synthesis of Bicyclo[3.1.0]hexane Derivatives as
`Li,
`Conformationally-Restricted
`Analogues
`of
`b-Arabinofuranosyl
`and
`a-
`Galactofuranosyl Rings” Org. Lett. 2008, 10, 881–884.
`Alfaro, J. A.; Zheng, R. B.; Persson, M.; Letts, J. A.; Polakowski, R.; Bai, Y.; Borisova, S. N.;
`Seto, N. O. L.; Lowary, T. L.; Palcic, M. M.; Evans*, S. V. “ABO(H) blood Group A and B
`Glycosyltransferases Recognize Substrate via Specific Conformational Changes” J.
`Biol. Chem. 2008, 283, 10097–10108.
`Hou, D.; Skogman, F.; Lowary*, T. L. “Synthesis of 8-azidooctyl Glycoside Derivatives
`of the O-chain Repeating Unit of Escherichia coli O9a Lipopolysaccharide and a
`Methylated analogue” Carbohydr. Res. 2008, 343, 1779–1790.
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`Rose, N. L.; Zheng, R. B.; Pearcey, J.; Zhou, R.; Completo, G. C.; Lowary*, T. L.
`“Development of a Coupled Spectrophotometric Assay for GlfT2, a Bifunctional
`Mycobacterial Galactofuranosyltransferase” Carbohydr. Res. 2008, 343, 2130–2139.
`Completo, G. C.; Lowary*, T. L. “Synthesis of Galactofuranose-Containing Acceptor
`Substrates for Mycobacterial Galactofuranosyltransferases” J. Org. Chem. 2008, 73,
`4513–4525.
`Shi, L.; Zhou, R.; Liu, Z.; Lowary, T. L.; Seeberger, P. H.; Stocker, B. L.; Crick, D. C.; Khoo,
`K.-H.; Chatterjee*, D. “Transfer of the First Arabinofuranose Residue to Galactan is
`Essential for Mycobacterial Viability” J. Bacteriol. 2008, 190, 5248–5255.
`Birch, H. J.; Alderwick, L. J.; Bhatt, A.; Rittmann, D.; Krumbach, K.; Singh, A.; Bai, Y.;
`Lowary, T. L. Eggeling, L.; Besra*, G. S. “Biosynthesis of Mycobacterial
`Arabinogalactan: Identification of a Novel a-(1®3) Arabinofuranosyltransferase” Mol.
`Microbiol. 2008, 69, 1191–1206.
`Phillips, R. L.; Kim, I.-K.; Carson, B. E.; Tidbeck, B.; Bai, Y.; Lowary, T. L.; Bunz*, U. H. F.
`“Sugar-Substituted Poly(para-phenyleneethynylenes) and their Interaction with
`Concanavalin A and Bacteria” Macromolecules 2008, 41, 7316–7320.
`Taha, H. A.; Castillo, N.; Roy*, P.-N.; Lowary*, T. L. “Conformational Studies of Methyl
`b-D-Arabinofuranoside Using the AMBER/GLYCAM Approach.” J. Chem. Theory
`Comput. 2009, 5, 430–438.
`Hou, D.; Lowary*, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application
`to 2,6-Dideoxy-pyranosides” J. Org. Chem. 2009, 74, 2278–2289. Selected as a Feature
`Article by JOC editor.
`Carapito, R.; Imberty, A.; Jeltsch, J.-M.; Byrns, S. C.; Tam, P.-H.; Lowary, T. L.; Varrot*, A.;
`Phalip, V. “Molecular Basis of Arabinobio-hydrolase Activity in Phytopathogenic
`Fungi. Crystal Structure and Catalytic Mechanism of Fusarium graminearum GH93
`a-L-arabinofuranosidase” J. Biol. Chem. 2009, 284, 12285–12296.
`86. Meloncelli, P. J.; Lowary*, T. L. “Synthesis of ABO Type V and VI Antigens” Aust. J.
`Chem. 2009, 62, 558–574.
`Hou, D.; Lowary*, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application
`to Furanosyl Azides and C-glycosides” Tetrahedron 2009, 65, 5916–5921.
`Szczepina, M. G.; Zheng, R. B.; Completo, G. C.; Lowary*, T L.; Pinto*, B. M. “STD-NMR
`Studies Suggest
`that Two Acceptor Substrates
`for GlfT2, a Bifunctional
`Galactofuranosyltransferase Required for the Biosynthesis of Mycobacterium
`tuberculosis Arabinogalactan, Compete for the Same Binding Site” ChemBioChem 2009,
`10, 2052–2059.
`Shi, W.; Coleman, R. S.; Lowary*, T. L. “Synthesis and DNA-Binding Affinity Studies of
`Glycosylated Intercalators Designed as Functional Mimics of the Anthracycline
`Antibiotics” Org. Biomol. Chem. 2009, 3709–3722.
`90. Murase, T.; Zheng, R. B.; Joe, M.; Bai, Y.; Marcus, S. L.; Lowary*, T. L.; Ng*, K. K. S.
`“Structural Insights into Host Recognition of Mycobacterial Polysaccharides” J. Mol.
`Biol. 2009, 392, 381–392.
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`Hou, D.; Taha, H. A.; Lowary*, T. L. “2,3-Anhydrosug