UNITED STATES PATENT AND TRADEMARK OFFICE
`
`CERTIFICATE OF CORRECTION
`
`PATENT NO.
`APPLICATION NO.
`
`: 10,106,603 B2
`: 15/988463
`
`DATED
`INVENTOR(S)
`
`: October 23, 2018
`: Stuart Alexander Cook et al.
`
`Page 1 of]
`
`it is certified that error appears in the above-identified patent and that said Letters Patent is hereby corrected as shown below:
`
`In the Claims
`
`At Column 93, Claim 1, Lines 15-16, the text:
`“A method of treating fibrosis in the human subject, the method comprising administering to a human
`subject in”
`Should be replaced with the text:
`--A method of treating fibrosis in a human subject, the method comprising administering to the human
`subject in--.
`
`Signed and Sealed this
`
`Fifth Day of February, 2019
`
`Andrei Iancu
`Director afthe United States Patent and Trademark Qfi’ice
`
`Singapore Exhibit 2001
`Singapore Exhibit 2001
`Lassen v. Singapore et al.
`Lassen V. Singapore et a1.
`PGR2019-00053
`PGR2019-00053
`
`Ex. 2001 - Page1
`Ex. 2001 - Page1
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Docket No.: M0546.70012USOl
`
`(PATENT)
`
`First Named Inventor:
`
`Stuart Alexander Cook
`
`Application No.:
`Confirmation No.2
`
`15/988,463
`7597
`
`Filed:
`Patent No.:
`Issued:
`For:
`Examiner:
`Art Unit:
`
`May 24, 2018
`10,106,603
`October 23, 2018
`TREATMENT OF FIB ROSIS
`P. M. Mertz
`1646
`
`Certificate of Electronic Filing under 37 C.F.Ft. § 1.3
`I hereby certitythat this paper (along with any paper reierred to as being attached or enclosed) is being transmitted via the Oifice's electronic filing
`system in accordance with 37 C.F.R. § 1.6(a)( ).
`
`/Nancy J. Arsenauit/
`
`Dated: January 10, 2019
`
`Electronic Signature for Nanch. Arsenauit:
`
`RES QUEST FOR CERTIFICATE OF CORRECTION PURSUANT TO 37 CFR 1.322
`
`Attention: Certificate of Correction Branch
`Commissioner for Patents
`PO. Box 1450
`
`Alexandria, VA 22313-1450
`
`Dear Sir:
`
`Upon reviewing the above-identified patent, Patentee noted an error which should be
`
`corrected.
`
`In the Claims:
`
`At column 93, Claim 1, lines 15-16, the text:
`
`“A method of treating fibrosis in the human subject, the method comprising administering to
`
`a human subject in” should be replaced with the text --A method of treating fibrosis in a human
`
`subject, the method comprising administering to the human subject i1 --.
`
`67556761
`
`Ex. 2001 - Page2
`Ex. 2001 - PageZ
`
`

`

`Patent No.: 10,106,603
`
`2
`
`Docket No.: M0546.70012USOl
`
`This error was made by the USPTO as evidenced by the claims in the Preliminary
`
`Amendment filed by Applicant on May 24, 2018 and the Examiner’s Amendment to the claims in
`
`the Notice of Allowance dated August 3, 2018. See, in particular, claim 1 on page 3 of the
`
`Preliminary Amendment and the Examiner’s Amendment to claim 1 on page 2 of the Notice of
`
`Allowance. Accordingly, no fee is required.
`
`Transmitted herewith is a proposed Certificate of Correction effecting such amendment.
`
`Patentee respectfully solicits the granting of the requested Certificate of Correction.
`
`Applicant believes no fee is due with this request. However, if a fee is due, please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012U301 from which the undersigned is
`
`authorized to draw.
`
`Dated: January 10, 2019
`
`Respectfully submitted,
`
`By /Amy McMahon Krom/
`Amy McMahon Krom, PhD
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS, PC.
`600 Atlantic Avenue
`
`Boston, Massachusetts 02210-2206
`617.646.8000
`
`67556761
`
`Ex. 2001 - Page3
`Ex. 2001 - Page3
`
`

`

`PTO/SW44 (0907)
`Approved for use through 01/31/2020. OMB 0651 -0033
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it displays a valid OMB control number.
`(Also Form PTO-1050)
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`CERTIFICATE OF CORRECTION
`
`PATENT NO.
`
`APPLICATION NO.
`
`ISSUE DATE
`
`:
`
`:
`
`:
`
`10,106,603
`
`15/988,463
`
`October 23, 2018
`
`INVENTOR(S)
`
`:
`
`Stuart Alexander Cook et al.
`
`It is certified that an error appears or errors appear in the above—identified patent and that said
`Letters Patent is hereby corrected as shown below:
`
`In the Claims:
`
`At column 93, Claim 1, lines 15-16, the text:
`
`“A method of treating fibrosis in the human subject, the method comprising administering
`to a human subject in" should be replaced with the text ——A method of treating fibrosis in a human
`
`subject, the method comprising administering to the human subject in--.
`
`MAILING ADDRESS OF SENDER (Please do not use Customer Number below):
`Amy McMahon Krom, PhD
`WOLF, GREENFIELD & SACKS, PC.
`600 Atlantic Avenue
`Boston, Massachusetts 02210—2206
`
`1
`
`67557661
`
`Ex. 2001 - Page4
`Ex. 2001 - Page4
`
`

`

`Electronic Acknowledgement Receipt
`
`“—
`
`——
`
`
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`First Named Inventor/Applicant Name:
`
`Stuart AlexanderCook
`
`Customer Number:
`
`23628
`
`Amy McMahon Krom/Nancy Arsenault
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012USOT
`
`Receipt Date:
`
`Filing Date:
`
`10—JAN—201 9
`
`24—MAY—2018
`
`Time Stamp:
`
`13:20:06
`
`
`
`Application Type: Utility under 35 USC 111(a)
`
`Payment information:
`
`Submitted with Payment
`
`2739da
`
`Document
`Number
`
`Document Descri
`
`tion
`
`p
`
`File SizelBytes)I
`Message Digest
`
`Pages
`Multi
`Part I.zip (if appl.)
`
`Miscellaneous Incoming Letter
`
`M054670012USOT—TRN—AM.pdf 3L1b489lb1delebb89d766db2732b5d7d
`
`Ex. 2001 - Page5
`Ex. 2001 - PageS
`
`

`

`Information:
`
`Request for Certificate of Correction
`
`M054670012USOl—RFCOC—AM.
`pdf
`
`175508ef030071/ffec83ef7b318c1b068/ 3 I
`
`Warnings:
`Information:
`
`
`
`M054670012USO1—COC—AM.pd IUSbZC |659| 28d7a495 | 95112301142983)
`7:991
`
`the application.
`
`New Applications Under 35 U.S.C. 111
`lfa new application is being filed and the application includes the necessary components for a filing date (see 37 CFR
`1.53(b)—(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shown on this
`Acknowledgement Receipt will establish the filing date of the application.
`National Stage of an International Application under 35 U.S.C. 371
`If a timely submission to enter the national stage of an international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT/DOIEOI903 indicating acceptance of the application as a
`national stage submission under 35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`New International Application Filed with the USPTO as a Receiving Office
`lfa new international application is being filed and the international application includes the necessary components for
`an international filing date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`and of the International Filing Date (Form PCT/ROI105) will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this Acknowledgement Receipt will establish the international filing date of
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`Request for Certificate of Correction
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`Total Files Size (in bytes)
`
`This Acknowledgement Receipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable. It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`Ex. 2001 - Page6
`Ex. 2001 - PageG
`
`

`

`Doc Code: TRAN.LET
`Document Description: Transmittal Letter
`
`TRANSM ITTAL
`
`USED IN LIEU OF PTO/SB/21 (07-09)
`
`FORM
`
`(to be used for all correspondence after initial filing)
`—-
`
`ENCLOSURES (Check all that apply)
`
`'1 Fee Transmittal Form
`
`D Drawing(s)
`
`|:| Licensing-related Papers
`-
`-
`i:i Petition
`
`Petition to Convert t.° a
`Provrsronal Applicatlon
`Power of Attorney, Revocation
`Change of Correspondence Address
`
`-
`-
`-
`l1 AffldaVIts/declaratlon(s)
`
`gfijerCAllowance communication
`
`Appeal Communication to Board
`of Appeals and Interferences
`Appeal Communication to TC
`(Appeal Notice, Brief, Reply Brief)
`
`Proprietary Information
`
`Status Letter
`
`
`
`
`Extension of Time Request
`
`|:| Terminal Disclaimer
`
`Express Abandonment Request
`
`|:| Request for Refund
`
`Information Disclosure Statement
`
`Certified Copy Of Priority
`Document(s)
`
`|:| CD, Number of CD(s)
`
`
`
`
`
`Landscape Table on CD
`
`
`
`
`
`
`
`
`
`
`X Other E"C|osure(5) (please
`Identity below):
`
`Request for certificate 0f
`Correction
`Certificate of Correction
`
`
`
`Reply to Missing Parts/
`_ Incomplete Application
`
`Reply to Missing Parts
`under 37 CFR 1.52 or 1.53
`
`WOLF, GREENFIELD & SACKS, P.C.
`
`Signature
`
`- /Amy McMahon Krom/
`
`Printed name Amy McMahon Krom. PhD
`
`Date
`
`January 10, 2019
`
`Certificate of Electronic Filing under 37 c.F.R. § 1.8
`I hereby certitythat this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic
`filing system in accordance with 37 C.F.R.§1.6(a)( ).
`
`Dated: January 10, 2019
`
`Electronic Signature for Nancy J. Arsenauit:
`
`/Nancy .J. Arsenault/
`
`67560961
`
`Ex. 2001 - Page7
`Ex. 2001 - Page7
`
`

`

`PTO/SB/47 (0309)
`Approved for use through 07/31/2018. OMB 065170016
`US. Patent and Trademark Office; U. S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of in1ormation unless it displays a valid OMB control number.
`
`“FEE ADDRESS” INDICATION FORM
`
`Address to:
`Mail Stop M Correspondence
`Commissioner for Patents
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`Fax to:
`571 -273-6500
`
`In addition,
`INSTRUCTIONS: The issue fee must have been paid for application(s) listed on this form.
`only an address represented by a Customer Number can be established as the fee address for maintenance
`fee purposes (hereafter, fee address). A fee address should be established when correspondence related to
`maintenance fees should be mailed to a different address than the correspondence address for the application.
`When to check the first box below: If you have a Customer Number to represent the fee address. When
`to check the second box below: If you have no Customer Number representing the desired fee address,
`in which case a completed Request for Customer Number (PTO/SB/125) must be attached to this form. For
`more information on Customer Numbers, see the Manual of Patent Examining Procedure (MPEP) §403.
`
`For the following listed application(s), please recognize as the ”Fee Address” under the provisions of 37 CFR
`1.363 the address associated with:
`
`Customer Number:
`OR
`
`020016
`
`D The attached Request for Customer Number (PTO/SB/125) form.
`PATENT NUMBER
`(it known)
`
`APPLICATION NUMBER
`
`10106603 -
`
`Completed by((check one.
`D Applicant/Inventor
`
`/Amy McMahon Krom/
`Signature
`
`Attorney or Agent of record
`
`
`73,073
`Amy McMahon Krom
`(Reg. No.)
`Typed or printed name
`Assignee of record of the entire interest. See 37 CFR 3.71.
`Statement under 37 CFR 3.73(b) is enclosed.
`(Form PTO/SB/QG)
`
`61?-646-8000
`Requesters telephone number
`
` 1
`
`Assignee recorded at Reel
`
`December 14, 2018
`Date
`NOTE: Signatures of all the inventors or assignees of record of the entire interest or their representative(s) are required. Submit multiple forms it more that one
`signature is required, see below*.
`
`Frame
`
`|:| * Total of
`
`forms are submitted.
`
`Certificate 01 Electronic Filing under 37 c.F.R. § 1.8
`I hereby certify that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic filing
`system in accordance with 37 CFR. § 1.6(a)(4).
`
`Dated: December 14, 2018
`
`Electronic Signature for Brenda M. White:
`
`i’Brenda M. White/
`
`6837861 .1
`
`Ex. 2001 - Page8
`Ex. 2001 - PageS
`
`

`

`Electronic Acknowledgement Receipt
`
`“—
`
`——
`
`
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`First Named Inventor/Applicant Name:
`
`Stuart AlexanderCook
`
`Customer Number:
`
`23628
`
`Amy McMahon Krom/Brenda White
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012USO1
`
`Receipt Date:
`
`Filing Date:
`
`14—DEC—201 8
`
`24—MAY—2018
`
`Time Stamp:
`
`12:54:01
`
`
`
`Application Type: Utility under 35 USC 111(a)
`
`Payment information:
`
`Submitted with Payment
`
`defl
`
`Document
`Number
`
`Document Descri
`
`tion
`
`p
`
`File SizelBytes)I
`Message Digest
`
`Pages
`Multi
`Part I.zip (if appl.)
`
`Transmittal Letter
`
`M054670012USOT—TRN—AM.pdf 504db60c17c101614978L13 H6957dd2053
`
`Ex. 2001 - Page9
`Ex. 2001 - PageQ
`
`

`

`Warnings:
`Information:
`
`Total Files Size (in bytes)
`
`This Acknowledgement Receipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable. It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`Information:
`
`Maintenance Fee Address Change
`
`M054670012USO1—CHA—AM.pd' 368d73dc65865084d2cf100/ea45db89281
`DecOe
`
`
`
`
`New Applications Under 35 U.S.C. 111
`lfa new application is being filed and the application includes the necessary components for a filing date (see 37 CFR
`1.53(b)—(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shown on this
`Acknowledgement Receipt will establish the filing date of the application.
`
`National Stage of an International Application under 35 U.S.C. 371
`If a timely submission to enter the national stage of an international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT/DOIEOI903 indicating acceptance of the application as a
`national stage submission under 35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`New International Application Filed with the USPTO as a Receiving Office
`lfa new international application is being filed and the international application includes the necessary components for
`an international filing date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`and of the International Filing Date (Form PCT/ROI105) will be issued in due course, subject to prescriptions concerning
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`
`Ex. 2001 - Page10
`Ex. 2001 - Page10
`
`

`

`Doc Code: TRAN. LET
`Document Description: Transmittal Letter
`
`TRANSM ITTAL
`
`USED IN LIEU OF PTO/SB/21 (07-09)
`
`FORM
`
`{to be used for all correspondence after initial filing)
`
`ENCLOSURES (Check all that apply)
`
`
`
`
`
`
`
`
`Drawing(s)
`
`Licensing-related Papers
`-
`-
`Petltlon
`
`Petition to com?“ t9 a
`_ Prowslonal Application
`— Power of Attorney, Revocation
`_ Change of Correspondence Address
`
`Terminal Disclaimer
`
`Request for Refund
`
`
`
`CD, Number of CD(s)
`
`I: Landscape Table Ol'i CD
`
`I: gttlerCAllowance communication
`
`I: Appeal communication to Board
`of Appeals and Interferences
`Appeal Communication to TC
`i: (Appeal Notice, Briet, Reply Brief)
`
`I: Proprietary Information
`
`Status Letter
`
`'2 Other Enclosure(s) (please
`Identify below):
`
`Fee Address Indication Form
`
`D Fee Transmittal Form
`
`'1 Fee Attached
`
`i1 Amendment/Reply
`
`'1 After Final
`-
`-
`-
`l1 AffidaVIts/declaratlon(s)
`
`I: Extension of Time Request
`
`I: Express Abandonment Request
`
`I: Information Disclosure Statement
`
`I: Certified Copy Of Priority
`Document(s)
`Reply to Missing Parts/
`Incomplete Application
`
`Reply to Missing Parts
`under 37 CFR 1.52 or 1.53
`
`
`
`WOLF, GREENFIELD & SACKS, P.C.
`
`Signature
`
`- /Amy McMahon Krom/
`P.
`”med name Amy McMahon Krom
`
`
`Date
`
`December 14, 2018
`
`Certificate of Electronic Filing under 37 c.F.R. § 1.8
`I hereby certify that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic
`iiiing system in accordance with 37 CFR. §1.6(a)(4).
`
`Dated: December 14, 2018
`
`Electronic Signature for Brenda M. White:
`
`iBrenda M. White/
`
`6837857.1
`
`Ex. 2001 - Page11
`Ex. 2001 - Page11
`
`

`

`To:
`From:
`Cc:
`Subject:
`
`Patents_eOfficeAction@WolfGreenfield.com,WGS_eOfficeActio n@WolfGreenfield.com,
`PAIRieOfficeAction@uspto.gov
`PAlR_eOfficeAction@uspto.gov
`Private PAIR Correspondence Notification for Customer Number 23628
`
`Oct 04, 2018 04:51 :20 AM
`
`Dear PAIR Customer:
`
`WOLF GREENFIELD & SACKS, PC.
`600 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES
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`The following USPTO patent application(s) associated with your Customer Number, 23628 , have
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`
`Application
`15988463
`
`Document
`ISSUE.NTF
`
`Mailroom Date
`10/03/2018
`
`Attorney Docket No.
`M0546.70012USO1
`
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`Ex. 2001 - Page12
`Ex. 2001 - Page12
`
`

`

`UNITED STATES PATENT AND TRADEMARK OEEICE
`
`
`
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address: COMIVIISS IONER FOR PATENTS
`PO Box 1450
`Alexandria Virginia 22313-1450
`www.uspt0 gov
`
`APPLICATION NO.
`
`15/988.463
`
`ISSUE DATE
`
`10/23/2018
`
`PATENT NO.
`
`10106603
`
`ATTORNEY DOCKET NO.
`
`CONFIRMATION NO.
`
`M0546.70012U801
`
`7597
`
`23628
`
`7590
`
`10/03/2018
`
`W()le GREENFIELD & SACKS, l’.C.
`600 ATLANTIC AVENUE
`BOSTON. MA 02210—2206
`UNITED STATES OF AMERICA
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`The projected patent number and issue date are specified above.
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`ISSUE NOTIFICATION
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`Determination of Patent Term Adjustment under 35 U.S.C. 154 (b)
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`The Patent Term Adjustment is 0 day(s). Any patent to issue from the above-identified application will include
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`
`APPLICANT(S) (Please see PAIR WEB site http://pairllspto gov for additional applicants):
`
`Stuart Alexander Cook, Singapore, SINGAPORE;
`Singapore Health Services PTE LTD., Singapore, SINGAPORE;
`National University of Singapore, Singapore, SINGAPORE;
`Sebastian Schaefer, Singapore, SINGAPORE;
`
`The United States represents the largest, most dynamic marketplace in the world and is an unparalleled location
`for business investment, innovation, and commercialization of new technologies. The USA offers tremendous
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`
`IR103 (ReV. 10/09)
`
`Ex. 2001 - Page13
`Ex. 2001 - Page13
`
`

`

`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address: COMMISSIONER FOR PATENTS
`I’D. Box I450
`Alexandria, Virginia 223I3-1450
`www.mptclgov
`
`APPLICATION NO
`
`FILING DATE
`
`FIRST NAMED INVENTOR
`
`ATTORNEY DOCKET NO.
`
`CONFIRMATION NO.
`
`15/988,463
`
`05/24/2018
`
`Stuart Alexander Cook
`
`M0546.700]2USOI
`
`7597
`
`°9’”’2°'8 —WOLF GREENFIELD & SACKS, no. u
`”9°
`”6"
`600 ATLANTIC AVENUE
`MERTZ' PREMA MARIA
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`UNITED STATES OF AMERICA
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`ART UNIT
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`09/25/20] 8
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`following e-mail address(es):
`Patents_eOfficeAction@WolfGreenfield.com
`WGS_eOfficeAction@WolfGreenfie1d.com
`
`PTOL-90A (Rev. 04/07)
`
`Ex. 2001 - Page14
`Ex. 2001 - Page14
`
`

`

`Application No.
`
`-- The MAILING DA TE of this communication appears on the cover sheet with the correspondence address —
`
`1. E The amendment filed on 20 September 2018 under 37 CFR 1.312 has been considered, and has been:
`
`a) E entered.
`
`b) I] entered as directed to matters of form not affecting the scope of the invention.
`
`c) [:I disapproved because the amendment was filed after the payment of the issue fee.
`
`Any amendment filed after the date the issue fee is paid must be accompanied by a petition under 37 CFR 1.313(c)(1) and
`the required fee to withdraw the application from issue.
`
`Applicant(s)
`15/988,463
`
`Response to Rule 312 Communication
`
`
`
`
`
`
`
`
`
`d) E] disapproved. See explanation below.
`
`e) [I entered in part. See explanation below.
`
`
`
`
`CHiIIiard
`
`U.S. Palent and Trademark Office
`PTOL-271 (Rev. 04-01)
`
`Reponse to Rule 312 Communication
`
`Part of Paper No.
`
`Ex. 2001 - Page15
`Ex. 2001 - Page15
`
`

`

`To:
`From:
`Cc:
`Subject:
`
`Patents_eOfficeAction@WolfGreenfield.com,WGS_eOfficeActio n@WolfGreenfield.com,
`PAIRieOfficeAction@uspto.gov
`PAlR_eOfficeAction@uspto.gov
`Private PAIR Correspondence Notification for Customer Number 23628
`
`Sep 25, 2018 03:35:28 AM
`
`Dear PAIR Customer:
`
`WOLF GREENFIELD & SACKS, PC.
`600 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES
`
`The following USPTO patent application(s) associated with your Customer Number, 23628 , have
`new outgoing correspondence. This correspondence is now available for viewing in Private PAIR.
`
`The official date of notification of the outgoing correspondence will be indicated on the form PTOL—90
`accompanying the correspondence.
`
`Disclaimer:
`
`The list of documents shown below is provided as a courtesy and is not part of the official file
`wrapper. The content of the images shown in PAIR is the official record.
`
`Application
`15988463
`
`Document
`N271
`
`Mailroom Date
`09/25/2018
`
`Attorney Docket No.
`M0546.70012U801
`
`To view your correspondence online or update your email addresses, please visit us anytime at
`https://sportal.uspto.gov/secure/myportal/privatepair.
`
`If you have any questions, please email the Electronic Business Center (EBC) at EBC@uspto.gov
`with 'e-Office Action' on the subject line or call 1-866-217-9197 during the following hours:
`
`Monday - Friday 6:00 am. to 12:00 am.
`
`Thank you for prompt attention to this notice,
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`PATENT APPLICATION INFORMATION RETRIEVAL SYSTEM
`
`Ex. 2001 - Page16
`Ex. 2001 - Page16
`
`

`

`To:
`From:
`Cc:
`Subject:
`
`Patents_eOfficeAction@WolfGreenfield.com,WGS_eOfficeActio n@WolfGreenfield.com,
`PAIRieOfficeAction@uspto.gov
`PAlR_eOfficeAction@uspto.gov
`Private PAIR Correspondence Notification for Customer Number 23628
`
`Sep 21, 2018 04:10:24 AM
`
`Dear PAIR Customer:
`
`WOLF GREENFIELD & SACKS, PC.
`600 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES
`
`The following USPTO patent application(s) associated with your Customer Number, 23628 , have
`new outgoing correspondence. This correspondence is now available for viewing in Private PAIR.
`
`The official date of notification of the outgoing correspondence will be indicated on the form PTOL—90
`accompanying the correspondence.
`
`Disclaimer:
`
`The list of documents shown below is provided as a courtesy and is not part of the official file
`wrapper. The content of the images shown in PAIR is the official record.
`
`Application
`15988463
`
`Document
`NTC. PUB
`
`Mailroom Date
`09/20/2018
`
`Attorney Docket No.
`M0546.70012USO1
`
`To view your correspondence online or update your email addresses, please visit us anytime at
`https://sportal.uspto.gov/secure/myportal/privatepair.
`
`If you have any questions, please email the Electronic Business Center (EBC) at EBC@uspto.gov
`with 'e-Office Action' on the subject line or call 1-866-217-9197 during the following hours:
`
`Monday - Friday 6:00 am. to 12:00 am.
`
`Thank you for prompt attention to this notice,
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`PATENT APPLICATION INFORMATION RETRIEVAL SYSTEM
`
`Ex. 2001 - Page17
`Ex. 2001 - Page17
`
`

`

`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`
`
` APPLICATION NUMBER FILING OR 371(C) DATE FIRST NAVED APPLICANT ATTY. DOCKET NOJTITLE
`
`
`
`UVTTET‘I STATES DEPARTWF‘NT 0F COM'MFIRCFI
`United States Patent and Trademark Office
`Addtess. COMB/TTSSTOVFR FOR PATENTS
`PO BOX 1450
`Alexandria,‘.’ngnia 22313-1450
`www.uspto.gov
`
`
`15/988,463
`05/24/2018
`Stuart Alexander Cook
`MOS46.70012USOI
`CONFIRMATION NO. 7597
`PUBLICATION NOTICE
`
`23628
`WOLF GREENFIELD & SACKS, P.C.
`600 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`
`l|||l|||||||||||||||||Illllllllllllllllllllllllllfllll||||||||I||||l|||l|||||||||||l|||
`000000 02 65979
`
`Title:TREATMENT OF FIBROSIS
`
`Publication No.US-2018—0265579-A1
`Publication Date:09/20/2018
`
`NOTICE OF PUBLICATION OF APPLICATION
`
`The above—identified application will be electronically published as a patent application publication pursuant to 37
`CFR 1.211, et seq. The patent application publication number and publication date are set forth above.
`
`The publication may be accessed through the USPTO‘s publically available Searchable Databases via the
`Internet at www.uspto.gov. The direct link to access the publication is currently http://www.uspto.gov/patft/.
`
`The publication process established by the Office does not provide for mailing a copy of the publication to
`applicant. A copy of the publication may be obtained from the Office upon payment of the appropriate fee set
`forth in 37 CFR 1.19(a)(1). Orders for copies of patent application publications are handled by the USPTO's
`Public Records Division. The Public Records Division can be reached by telephone at (571) 272-3150 or (800)
`972-6382, by facsimile at (571) 273-3250, by mail addressed to the United States Patent and Trademark Office,
`Public Records Division, Alexandria, VA 22313-1450 or via the Internet.
`
`In addition, information on the status of the application, including the mailing date of Office actions and
`the dates of receipt of correspondence filed in the Office, may also be accessed via the Internet through
`the Patent Electronic Business Center at www.uspto.gov using the public side of the Patent Application
`Information and Retrieval (PAIR) system. The direct link to access this status information is currently
`https://portal.uspto.gov/pair/PublicPair. Prior to publication, such status information is confidential and may only
`be obtained by applicant using the private side of PAIR.
`
`Further assistance in electronically accessing the publication, or about PAIR, is available by calling the Patent
`Electronic Business Center at 1-866-217—9197.
`
`
`
`Office of Data Managmcnt, Application Assistance Unit (571) 272-4000, or (571) 272-4200, or 1-888-786-0101
`
`page 1 of 1
`
`Ex. 2001 - Page18
`Ex. 2001 - Page18
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Docket No.: M0546.70012USOl
`
`(PATENT)
`
`First Named Inventor:
`
`Stuart Alexander Cook
`
`Application No.:
`Confirmation No.2
`
`15/988,463
`7597
`
`Filed:
`For:
`Examiner:
`Art Unit:
`
`May 24, 2018
`TREATMENT OF FIB ROSIS
`P. M. Mertz
`1646
`
`Certificate of Electronic Filing under 37 C.F.Ft. § 1.3
`I hereby certitythat this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic filing
`system in accordance with 37 C.F.R. § 1.6( )(4).
`
`/Nancy .J. Arsenauit/
`
`Dated: September 20, 2018
`
`Electronic Signature for Nancy J. Arsenauit:
`
`
`
`AMENDMENT AFTER ALLOWANCE UNDER 37 C.F.R. 1.312
`
`Mail Stop Issue Fee
`Commissioner for Patents
`PO. Box 1450
`
`Alexandria, VA 22313-1450
`
`Dear Sir:
`
`INTRODUCTORY COMMENTS
`
`In response to the Notice to File Corrected Application Papers dated September 19, 2017,
`
`please amend the above-identified US. patent application as follows:
`
`Amendments to the Specification begin on page 2 of this paper.
`
`Remarks/Arguments begin on page 3 of this paper.
`
`66274281
`
`Ex. 2001 - Page19
`Ex. 2001 - Page19
`
`

`

`Application No: 15/988,463
`Amendment dated September 20, 2018
`After Allowance Under 37 C.F.R. § 1.312
`
`2
`
`Docket No.: M0546.70012U801
`
`ANIENDMENTS TO THE SPECIFICATION
`
`Please amend the Specification as follows:
`
`Please replace the paragraph starting on page 92, line 6 with the following replacement
`
`paragraph:
`
`We first generated RNA- seq data (Figure 16EPF914—Refierenee—seu-Pee—net—fermd7) and determined
`
`the genotype of 69 ethnically matched (Chinese) individuals in the cohort using a SNP array based
`
`on fluorescent probe hybridization supplied by Illumina (HumanOmniExpress 24).
`
`66274281
`
`Ex. 2001 - Page20
`Ex. 2001 - PageZO
`
`

`

`Application No.: 15/988,463
`Amendment dated September 20, 2018
`After Allowance Under 37 C.F.R. § 1.312
`
`3
`
`Docket No.: M054670012U801
`
`RENIARKS
`
`This paper is responsive to the Notice to File Corrected Application Papers dated
`
`September 19, 2017 (“Notice”). In the Notice, the Office indicated that page 92, line 6 of the
`
`specification submitted on May 24, 2018 contained the phrase “Error! Reference source not found.”
`
`By this amendment, Applicant has amended the specification to remove the phrase “Error!
`
`Reference source not found.” on page 92, line 6. No new matter has been added.
`
`Applicant believes no fee is due with this response. However, if a fee is due, please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012USO1 from which the undersigned is
`
`authorized to draw.
`
`Dated: September 20, 2018
`
`Respectfully submitted,
`
`By /Amy McMahon Krom]
`Amy McMahon Krom
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS, RC.
`600 Atlantic Avenue
`
`Boston, Massachusetts 02210—2206
`617.646.8000
`
`66274281
`
`Ex. 2001 - Page21
`Ex. 2001 - PageZ1
`
`

`

`
`
`Commissioner for Patents
`United States Patent and Trademark Office
`PO. Box 1450
`Alexandria, VA 22313-1450
`www.uspto.gov
`
`Application No. : 15988463
`Applicant
`: Cook
`Filing Date I 05/24/2018
`Date Mailed : 09/19/2018
`
`NOTICE TO FILE CORRECTED APPLICATION PAPERS
`
`Notice ofAllowance Mailed
`
`This application has been accorded an Allowance Date and is being prepared for issuance.
`application, however, is incomplete for the reasons below.
`
`The
`
`Applicant is given two (2) months from the mail date of this Notice within which to respond. This
`time period for reply is extendable under 37 CFR 1.136(a) for only TWO additional MONTHS.
`
`The informalities requiring correction are indicated in the attachment(s). If the informality pertains to the
`abstract, specification (including claims) or drawings,
`the informality must be corrected with an
`amendment in compliance with 37 CFR 1.121 (or, if the application is a reissue application, 37 CFR
`1173). Such an amendment may be filed after payment of the issue fee if limited to correction of
`informalities noted herein. See Waiver of 37 CFR 1.312 for Documents Required by the Office of Patent
`Publication, 1280 Off. Gaz. Patent Office 918 (March 23, 2004).
`In addition, if the informality is not
`corrected until after payment of the issue fee, for purposes of 35 U.S.C. 154(b)(l)(iv), “all outstanding
`requirements” will be considered to have been satisfied when the informality has been corrected. A
`failure to respond within the above-identified time period will
`result
`in the application being
`ABANDONED.
`
`See attachment(s).
`
`
`A copy of this notice MUST be returned with the reply. Please address response to
`“Mail Stop Issue Fee, Commissioner for Patents,
`P. 0. Box 1450, Alexandria, VA 22313-1450”.
`
`/Quang Nguyen/
`Publication Branch
`
`Office of Data Management
`(571) 272-4200
`
`Ex. 2001 - Page22
`Ex. 2001 - PageZZ
`
`

`

`Application No. 15988463
`
`IDENTIFICATION OF APPLICATION DEFICIENCIES
`
`IN APPLICATION FILED ON OR AFTER SEPTEMBER 16, 2012
`
`Applicant must provide legible text for the following item(s).
`
`
`
`Specification filed 12/ 16/2016. page(s) 922 line 6 1"E1rorl Reference source not found".
`
` X
`
` Other: .
`
`
`
`Claims filed , claim(s) .
`
`
`
`|:| Applicant must provide missing information on the following page(s) of the specification by amending the
`specification to add the missing text. No new matter may be added.
`Page/line 110(5).
`
`CI
`
`The specification refers to one or more applications by attorney docket number and