UNITED STATES PATENT AND TRADEMARK OFFICE
`
`CERTIFICATE OF CORRECTION
`
`PATENT N0.
`APPLICATION NO.
`
`: 10,106,603 32
`: 151’988463
`
`DATED
`INVENTOR(S)
`
`: October 23, 2018
`: Stuart Alexander Cook ct al.
`
`page 1 of 1
`
`It is certified that error appears in the above-identified patent and that said Letters Patent is hereby corrected as shown below:
`
`In the Claims
`
`At Column 93, Claim 1, Lines 15-16, the text:
`
`“A method of treating fibrosis in the human subject, the method comprising administering to a human
`
`subject in”
`
`Should be replaced with the text:
`
`--A method of treating fibrosis in a human subject, the method comprising administering to the human
`
`subject in--.
`
`Signed and Sealed this
`
`Fifth Day of February, 2019
`
`Awash-W
`
`Andrei Iancu
`
`Director qffhe United States Parent and iri‘ademw‘k Qfl'fce
`
`Lassen - Exhibit 1002, p. 1
`Lassen — Exhibit 1002, p. 1
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Docket No.: M0546.70012U50]
`
`(PATENT)
`
`First Named Inventor:
`
`Stuan Alexander Cook
`
`Application N0.:
`Confirmation N0.:
`
`Filed:
`Patent No.:
`
`Issued:
`For:
`
`Examiner:
`
`Art Unit:
`
`15i’988,463
`7597
`
`May 24, 2018
`10,106,603
`
`October 23, 2018
`TREATMENT OF FIB ROSIS
`
`P. M. Mertz
`
`1646
`
`Certificate 01 Electronic Filing under 37 C.F.R. § 1.8
`I hereby certity that this paper (along with anyr paper referred to as being attached or enclosed) is being transmitted via the Office‘s electronic filing
`system in accordance with 3? C.F.R. § 1.6(a)(4).
`
`Electronic Signature for Nancy J. Arsenault: Nancy J. Arsenaull}
`
`Dated: January 10, 2019
`
`REQUEST FOR CERTIFICATE OF CORRECTION PURSUANT TO 37 CFR 1.322
`
`Attention: Certificate of Correction Branch
`Commissioner for Patents
`
`PO. Box 1450
`
`Alexandria, VA 22313—1450
`
`Dear Sir:
`
`Upon reviewing the above-identified patent, Patentee noted an error which should be
`
`corrected.
`
`In the Claims:
`
`At column 93, Claim 1. lines 15—16, the text:
`
`“A method of treating fibrosis in the human subject, the method comprising administering to
`
`a human subject in” should be replaced with the text --A method of treating fibrosis in a human
`
`subject, the method comprising administering to the human subject in——.
`
`67556761
`
`Lassen - Exhibit 1002, p. 2
`Lassen — Exhibit 1002, p. 2
`
`

`

`Patent No.: 10,106,603
`
`2
`
`Docket No.: M0546.70012US01
`
`This error was made by the USPTO as evidenced by the claims in the Preliminary
`
`Amendment filed by Applicant on May 24, 2018 and the Examiner’s Amendment to the claims in
`
`the Notice of Allowance dated August 3, 2018. See, in particular, claim 1 on page 3 of the
`
`Preliminary Amendment and the Examiner’s Amendment to claim 1 on page 2 of the Notice of
`
`Allowance. Accordingly, no fee is required.
`
`Transmitted herewith is a proposed Cenificate of Correction effecting such amendment.
`
`Patentee respectfully solicits the granting of the requested Certificate of Correction.
`
`Applicant believes no fee is due with this request. However, ifa fee is due, please charge
`
`Deposit Account No. 231’2825 under Docket No. M0546.70012USOI from which the undersigned is
`
`authorized to draw.
`
`Dated: January 10, 2019
`
`Respectfully submitted,
`
`By fAmy McMahon Kromi‘r
`Amy McMahon Krom. PhD
`Registration N0.: 73,073
`WOLF. GREENFIELD & SACKS. P.C.
`600 Atlantic Avenue
`
`Boston, Massachusetts 02210—2206
`617.646.8000
`
`6755676J
`
`Lassen - Exhibit 1002, p. 3
`Lassen — Exhibit 1002, p. 3
`
`

`

`PTOESBr44 (09-0?)
`Approved for use through 01i'31r2020. 0MB 0651—0033
`US. Patent and Trademark Oflioe; US. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act oi 1995, no persons are reqUIred to respond to a collection ot Information unless it displays a valid OMB control number.
`(Also Form PTO-1050
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`CERTIFICATE OF CORRECTION
`
`Page _1_ of _1_
`
`PATENT NO.
`
`APPLICATION NO.
`
`ISSUE DATE
`
`INVENTOFHS}
`
`:
`
`:
`
`:
`
`:
`
`10,106,603
`
`151988.463
`
`October 23, 2018
`
`Stuart Alexander Cook et at.
`
`subject, the method comprising administering to the human subject in——.
`
`It is certified that an error appears or errors appear in the above—identified patent and that said
`Letters Patent is hereby corrected as shown below:
`
`In the Claims:
`
`At column 93, Claim 1. lines 15—16, the text:
`
`"A method of treating fibrosis in the human subject, the method comprising administering
`
`to a human subject in" should be replaced with the text --A method of treating fibrosis in a human
`
`MAILING ADDRESS OF SENDEFI (Please do not use Customer Number below):
`Amy McMahon Krom, PhD
`WOLF, GFIEENFIELD & SACKS, PC.
`600 Atlantic Avenue
`Boston, Massachusetts 02210—2206
`
`1
`
`57557561
`Lassen - Exhibit 1002, p. 4
`Lassen — Exhibit 1002, p. 4
`
`

`

`Electronic Acknowledgement Receipt
`
`Application Number:
`
`15988463
`
`International Application Number:
`
`Confirmation Num ber:
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`
`
`First Named InventorIApplicant Name:
`
`Stuart Alexander Cook
`
`
`
`Filer: Amy McMahon Krom/Nancy Arsenault
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012USOI
`
`Receipt Date:
`
`10—JAN—2019
`
`
`
`Filing Date: 24-MAY-2018
`
`Time Stamp:
`
`13:20:06
`
`Application Type:
`
`Utility under 35 USC 111(a}
`
`Payment information:
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`Document
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`.
`
`.
`
`.
`
`File SizelBytesl!
`
`Multi
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`Pages
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`
`Miscellaneous Incoming Letter
`
`M054670012USO1—TRN—AM.pdf
`
`3:) EV- ElQ'fhl do 1 (I) blowflfifianflsl 355M
`2?]‘3da
`
`Lassen - Exhibit 1002, p. 5
`Lassen — Exhibit 1002, o. 5
`
`

`

`Request for Certificate ofCorrection
`
`M054670012USO‘I—RFCOC—AM.
`pdf
`
`1?.‘35039l'03mndfl0r3ael7 3313(1an 3
`[00
`
`
`
`Warnings:
`Information:
`
`Request for Certificate of Correction
`
`M054670012USO‘I—COC—AM.pd 105hlc1659128dh495196d hMflNmefi
`3:991
`
`
`
`Warnings:
`Information:
`
`the application.
`
`New Applications Under 35 U.S.C. 111
`Ifa new application is being filed and the application includes the necessary components for a filing date {see 37 CFR
`1.53(b}-[di and MPEP 506], a Filing Receipt {37 CFR 1.54) will be issued in due course and the date shown on this
`Acknowledgement Receipt will establish the filing date of the application.
`National Stage of an International Application under 35 U.S.C. 371
`Ifa timely submission to enter the national stage ofan international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCTIDOIEOi'903 indicating acceptance of the application as a
`national stage submission under 35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`New International Application Filed with the USPTO as a Receiving Office
`If a new international application is being filed and the international application includes the necessary components for
`an international filing date [see PCT Article 11 and MPEP181DJ, a Notification of the International Application Number
`and of the International Filing Date [Form PCTJROHOSI will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this Acknowledgement Receipt will establish the international filing date of
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`Total Files Size [in bytes)
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`This Acknowledgement Receipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable. It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`Lassen - Exhibit 1002, p. 6
`Lassen — Exhibit 1002, p. 6
`
`

`

`Doc Code: TRANLET
`Document Description: Transmittal Letter
`
`TRANSMITTAL
`
`USED IN LIEU OF PTOi’SBi21 (07-09}
`
`FORM
`
`(to be used for all correspondence after initial filing)
`
`Total Number of Pages in This Submission
`
`ENCLOSURES (Check all that apply)
`
`
`
`Fee Transmittal Form
`
`D Drawingls}
`
`
` I: Fee Attached
`
`
`Amendmenti'Reply
`
`
`
`|:| Licensing-related Papers
`.
`.
`l:l Pem'on
`
`gflegAllowance Communication
`
`Appeal communication to Board
`of Appeals and Interferences
`Appeal Communication to TC
`{Appeal Notice, Brier, Reply Brien
`
`I: After Final
`
`
`
`.
`-
`.
`I: Affidavrtsideclaration(s}
`
`Petition to COM?” l0 a
`Prowsional Application
`
`:l Propiietary Information
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`Power of Attorney. Revocation
`Change of Correspondence Address
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`:l
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`Status Letter
`
`
`
`
`
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`
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`
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`
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`
`Extension of Time Request
`
`|:| Terminal Disclaimer
`
`x Other ENCIOSUVE‘lS) (please
`Identify below):
`
`Express Abandonment Request
`
`|:| Request for Refund
`
`Information Disclosure Statement
`Certified Copy ot Priority
`Documentis)
`
`|:| CD, Number of CDis)
`
`
`
` Landscape Table on CD
`
`Requesl for Gemficale Ol
`Correction
`Certificate of Correction
`
`
`
`Reply to Missing Parts)r
`_ Incomplete Application
`
`Reply to Missing Parts
`under 37 CFR1.52 or 1.53
`
`SIGNATURE OF APPLICANT, ATTORNEY, OR AGENT
`
`Hm” Name
`Signature
`
`WOLF, GREENFIELD & SACKS, P.C.
`
`{Amy McMahon Kromf
`
`Printed name
`Amy McMahon Krom, PhD
`
`Dale
`
`January 10, 2019
`
`Certificate of Electronic Filing under 37 CPR. § 1.3
`I hereby certify that this paper {along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic
`filing system in accordance with 37" CPR. § l.6la)(4)_
`
`Dated: January 10. 2019
`
`Electronic Signature for Nancy .J. Arsenaull: Nancy .J. Arsenaulli’
`
`57560961
`Lassen - Exhibit 1002, p. 7
`Lassen — Exhibit 1002, p. 7
`
`

`

`PTOISBM? (03-09)
`Approved for use through 0?:‘31r'2018. 0MB 0651-0016
`U.S. Patent and Trademark Ollice: U. S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995. no persons are required to respond to a collection of information unless it displays a valid OMB control number.
`
`“FEE ADDRESS” INDICATION FORM
`
`Address to:
`Mail Stop M Correspondence
`Commissioner tor Patents
`P.0. Box 1450
`Alexandria, VA 2231 3-1 450
`
`Fax to:
`571-273-6500
`
`In addition.
`INSTRUCTIONS: The issue fee must have been paid for application(s} listed on this form.
`only an address represented by a Customer Number can be established as the tee address for maintenance
`fee purposes (hereafter, fee address). A fee address should be established when correspondence related to
`maintenance fees should be mailed to a different address than the correspondence address tor the application.
`When to check the first box below: If you have a Customer Number to represent the fee address. When
`to check the second box below: If you have no Customer Number representing the desired fee address,
`in which case a completed Request for Customer Number [PTOISBr125l must be attached to this form. For
`more information on Customer Numbers, see the Manual of Patent Examining Procedure (MPEP) § 403.
`
`For the following listed applicationts), please recognize as the ”Fee Address“ under the provisions of 37 CFR
`1363 the address associated with:
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`Customer Number:
`OR
`D The attached Request for Customer Number (PTOISBr125l form.
`
`020016
`
`APPLICATION NUMBER
`PATENT NUMBER
`(il known}
`
`10,106,603
`
`Completed by (check one):
`D Applicantr‘lnventor
`
`Attorney or Agent ot record
`
`73,073
`(Reg. No.)
`
`Assignee of record of the entire interest. See 37 CFR 3.71.
`Statement under 37 CFR 3.730)} is enclosed.
`(Form PTOISBIQSt
`
`
`rAmy McMahon Kromf
`Signature
`
`Amy McMahon Krom
`Typed or printed name
`
`61 7 646 8000'
`‘
`Requester s telephone number
`
`Frame
`
` 1
`
`Assignee recorded at Reel
`
`December 14, 2018
`Date
`NOTE: Signatures of all the inventors or assignees of record ot the entire interest or their representatiue(s) are required. Submit multiple forms it more that one
`Signature is required, see below‘.
`
`towns are submitted.
`
`Certificate of Electronic Filing under 3? C.F.H. § 1.3
`| herebyr certin that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Ollice‘s electronic tiling
`system in accordance with 3? C.F.Ft.§1.6(a){4).
`
`Dated: December 14. 2018
`
`Electronic Signature Ior Brenda M. White:
`
`r'Brenda NI. Whiter
`
`6837861.1
`Lassen - Exhibit 1002, p. 8
`Lassen — Exhibit 1002, p. 8
`
`

`

`Electronic Acknowledgement Receipt
`
`Application Number:
`
`15988463
`
`International Application Number:
`
`Confirmation Num ber:
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`
`
`First Named InventorIApplicant Name:
`
`Stuart Alexander Cook
`
`
`
`Filer: Amy McMahon Krom/Brenda White
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012USOI
`
`Receipt Date:
`
`14—DEC—201 8
`
`
`
`Filing Date: 24-MAY-2018
`
`Time Stamp:
`
`12:54:01
`
`Application Type:
`
`Utility under 35 USC 111(a}
`
`Payment information:
`
`Document
`
`.
`
`.
`
`.
`
`File SizelBytesl!
`
`Multi
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`
` Warnings:
`
`Transmittal Letter
`
`M054670012USO1—TRN—AM.pdf
`
`604::mel?c10l6|119?fic13i2695?aa2058
`Didi]
`
`Lassen - Exhibit 1002, p. 9
`Lassen — Exhibit 1002, o. 9
`
`

`

`Maintenance Fee Address Change
`
`M0546700‘I 2USOi—CHA—AM.pd‘ fifiad P.3drfififififioflfld 3r [ION-en’- Stl M9231
`Occur.-
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`
`
`Warnings:
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`Total Files Size (in bytes}
`
`Information:
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`
`This Acknowledgement Receipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable. It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`New Applications Under 35 U.S.C. 111
`Ifa new application is being filed and the application includes the necessary components for a filing date {see 37 CFR
`1.53{b)-[d] and MPEP 506}, a Filing Receipt {37 CFR 1 .54} will be issued in due course and the date shown on this
`Acknowledgement Receipt will establish the filing date ofthe application.
`National Stage of an International Application under 35 U.S.C. 371
`Ifa timely submission to enter the national stage ofan international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT!DO!EO!903 indicating acceptance of the application as a
`national stage submission under 35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`New International Application Filed with the USPTO asa Receiving Office
`Ifa new international application is being filed and the international application includes the necessary components for
`an international filing date [see PCT Article 11 and MPEP1810}, a Notification of the International Application Number
`and of the International Filing Date {Fo rm PCTIROMOS) will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this Acknowledgement Receipt will establish the international filing date of
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`Lassen - Exhibit 1002, p. 10
`Lassen — Exhibit 1002, p. 10
`
`

`

`Doc Code: TRANLET
`Document Description: Transmittal Letter
`
`TRANSMI'I'I'AL
`
`USED IN LIEU OF PTOr’SBi21 (07-09}
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`FORM
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`(to be used for alt correspondence after initiat filing)
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`lqoflTllAllowance Communication
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`Certified Copy of Priority
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`under 3? CFR 1.52 or 1.53
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`Landscape Table on CD
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`SIGNATURE OF APPLICANT, ATTORNEY, 0H AGENT
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`WOLF, GREENFIELD & SACKS, P.C.
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`Signature- fAmy McMahon Kromt
`
`Printed name Amy McMahon Krom
`
`Dale
`
`December 14, 2018
`
`Certificate of Electronic Filing under 3? C.F.Fl. § 1.3
`| hereb)r certin that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Oltice‘s electronic
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`
`Dated: December 14‘ 2018
`
`Electronic Signature Ior Brenda M. White:
`
`r'Brenda NI. Whiter
`
`5337857]
`Lassen - Exhibit 1002, p. 11
`Lassen — Exhibit 1002, p. 11
`
`

`

`
`
`UNITED S'l'A'l‘ES DEPA RTMENT OF COMMERCE
`United States Patent and Trademark ()Ificc
`Address: COMMISSIONER I‘OR FA'I'IiN'I‘S
`P.0. Box I450
`Alexandria, Virginia 223 I .‘l- | 450
`www.msptugiw
`
`APPLICATION NO.
`ISSUE DATE
` PATImT NO.
`
`ATTORNEY DOCKET NO.
`CONFIRNLATION NO.
`
`6388.463-
`IUQMZOI 8
`IUI 06603
`M0546J00 l BUSUI
`T59?
`
`23628
`
`759E]
`
`IIIIUIIIEIII S
`
`WOLF GREENEIEID & SACKS, RC.
`600 ATLANTIC AVENUE
`BOSTON, MA 02210—2206
`UNITED STATES OF AMERICA
`
`The projected patent number and issue date are specified above.
`
`ISSUE NOTIFICATION
`
`Determination of Patent Term Adjustment under 35 U.S.C. 154 (b)
`(application filed on or after May 29, 2000)
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`The Patent Term Adjustment is 0 day(s). Any patent to issue from the above-identified application will include
`an indication of the adjustment on the front page.
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`If a Continued Prosecution Application (CPA) was filed in the above—identified application, the filing date that
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`Any questions legarding the Patent Term Extension or Adjustment determination should be directed to the
`Office of Patent Legal Administration at (STD—2723702. Questions relating to issue and publication fee
`payments should be directed to the Application Assistance Unit (AAU) of the Office of Data Management
`(ODM) at (571)—272-4200.
`
`APPLICANT(S) I Please see PAIR WEB site httpflpairllsptogov for additional applicants):
`
`Stuart Alexander Cook, Singapore, SINGAPORE;
`Singapore Health Services PI‘E L'l‘D.. Singapore, SINGAPORE:
`National University of Singapore, Singapore, SINGAPORE;
`Sebastian Schaefer, Singapore, SINGAPORE;
`
`The United States represents the largest, most dynamic marketplace in the world and is an unparalleled location
`for business investment, innovation, and commercialization of new technologies. The USA offers tremendous
`resources and advantages for those who invest and manufacture goods here. Through SelectUSA, our nation
`works to encourage and facilitate business investment. To learn more about why the USA is the best country in
`
`the world to develop technology, manufacture products, and grow your business, visit SelectUSA.oov.
`Lassen - Exhibit 1002, p. 12
`Lassen — Exhibit 1002, p. 12
`
`[R103 (Rm 10mg)
`
`

`

`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address: COMMISSIONER FOR PATIENTS
`PO. Box ”50
`Nuandrin. Virginia 223 I3- MSG
`mnsplagev
`
`APPLICATION NO.
`
`FILING DATE
`
`FIRST NAM ED INVENTOR
`
`ATTORNEY DOCKET NO.
`
`CONFIRMATION NO.
`
`ӣ988,463
`
`USII‘UZOI 8
`
`Stuart Alexander Cook
`
`M0546300 l 2USOI
`
`I59”!
`
`WOLF GREENFIELD & SACKS. m m
`600 ATLANTIC AVENUE
`MERTZ. PREMA MARIA
`BOSTON, MA 02210-2206
`mvmowm
`
`I646
`
`NOTIFICATION DATE
`
`DELIVERY MODE
`
`09l25f2018
`
`ELECT RON [C
`
`Please find below andfor attached an Office communication concerning this application or proceeding.
`
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`PalentsanfficeAclion@WolfGreenfield.com
`WG S_eO fficeAction @WolfGrcen fieldcom
`
`PTOL-9UA (Rev. 04:0?)
`
`Lassen - Exhibit 1002, p. 13
`Lassen — Exhibit 1002, p. 13
`
`

`

`Response to Ruie 312 Communication
`
`Application No.
`
`Applicanfls)
`
`15i988,463
`
`-- The MAiLiNG DA TE of this communication appears on the cover sheet with the correspondence address —
`
`1. E The amendment filed on 20 September 2018 under 37 CFR 1.312 has been considered. and has been:
`
`a) Q entered.
`
`entered as directed to matters of form not affecting the scope of the invention.
`
`disapproved because the amendment was filed after the payment of the issue fee.
`
`Any amendment filed after the date the issue fee is paid must be accompanied by a petition under 37 CFR 1.313(c){1) and
`
`the required fee to withdraw the application from issue.
`
`CHilliard
`
`disapproved. See explanation below.
`
`entered in part. See explanation below.
`
`U.5. Patenl and Trademark Office
`
`PTOL-271 (Rev. 04-01}
`
`Reponse to Rule 312 Communication
`
`Part of Paper No.
`
`Lassen - Exhibit 1002, p. 14
`Lassen — Exhibit 1002, p. 14
`
`

`

`UNITED STATES PA'I‘ENT AND TRADEMARK OFFICE
`
`
`
`UNI'I‘I'II) S'I‘A’I‘I'E I)I‘II’AI{1‘E\IICN'I‘ UI" (.‘UM M I“. Ill’TI‘I
`United States Patent and 'I‘radmnnrk ("Tim
`Addicss. COMM ISSIE‘NI‘IH F‘OR PATENT-‘5
`PO Box I-lSO
`Alexandria. Vupcnizl 22313-1450
`w» w.|:5‘pln.gm'
`
`
`I
`APPLICATION NUMBER
`I
`FILING on 3mm DA'I'i-I
`I
`I-‘lRS’I‘ NAMILI) APPLICANT
`I
`A'l"l'Y. DOCKET N()_r1‘I'I'I.1.-:
`lSi'F)88,463
`05f241'201 8
`S lutu'l Alexander Cook
`M0546.70012USOI
`CONFIRMATION NO. 7597
`
`l
`
`23628
`
`WOLF GREENFIELD & SACKS, PC.
`500 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`
`PUBLICATION NOTICE
`
`lillililiIllIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIQIIIIIIIIIIIIIIIII
`
`Title:TREATMENT OF FIBFIOSIS
`
`Publication No.US-2018-0265579-A1
`Publication Date:09!20i’201 8
`
`NOTICE OF PUBLICATION OF APPLICATION
`
`The above-identified application will be electronically published as a patent application publication pursuant to 37
`CFR 1211, et seq. The patent application publication number and publication date are set forth above.
`
`The publication may be accessed through the USPTO‘s publically available Searchable Databases via the
`Internet at www.uspto.gov. The direct link to access the publication is currently httpvfwwwusptogovfpatftf.
`
`The publication process established by the Office does not provide for mailing a copy of the publication to
`applicant. A copy of the publication may be obtained from the Office upon payment of the appropriate fee set
`forth in 37 CFR 1.19(a)(1). Orders for copies of patent application publications are handled by the USPTO's
`Public Records Division. The Public Records Division can be reached by telephone at (571) 272—3150 or (800)
`972—6382, by facsimile at (571) 273—3250, by mail addressed to the United States Patent and Trademark Office,
`Public Records Division, Alexandria, VA 22313—1450 or via the Internet.
`
`In addition, information on the status of the application, including the mailing date of Office actions and
`the dates of receipt of correspondence filed in the Office, may also be accessed via the Internet through
`the Patent Electronic Business Center at www.uspto.gov using the public side of the Patent Application
`Information and Retrieval (PAIR) system. The direct link to access this status information is currently
`htlpsflportaluspto.govfpairfPublicPair. Prior to publication, such status information is confidential and may only
`be obtained by applicant using the private side of PAIR.
`
`Further assistance in electronically accessing the publication, or about PAIR, is available by calling the Patent
`Electronic Business Center at 1—866—21 7—9197.
`
`
`
`Office of Data Munagmcnl, Application Assistance Unit (57]) 272—4000, or (57] ) 272—4200, or 1—888—786-0101
`
`page 1 oil
`
`Lassen - Exhibit 1002, p. 15
`Lassen — Exhibit 1002, p. 15
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Docket No.: M0546.70012USO]
`
`(PATENT)
`
`First Named Inventor:
`
`Stuan Alexander Cook
`
`Application N0.:
`Confirmation N0.:
`
`151988.463
`7597
`
`Filed:
`For:
`Examiner:
`
`Art Unit:
`
`May 24, 2018
`TREATMENT OF FIB ROSIS
`P. M. Merle
`
`1646
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.3
`| herebg.r cenity that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office‘s electronic tiling
`system in accordance with 3? C.F.R. § 1.6(a)(4}.
`
`Electronic Signature for Nanci;r .J. Arsenault: {Nancy J. rifltrsenault.i
`
`Dated: September 20. 2018
`
`
`
`AMENDMENT AFTER ALLOWANCE UNDER 37 C.F.R. ' 1.312
`
`Mail Stop Issue Fee
`Commissioner for Patents
`
`PO. Box 1450
`
`Alexandria, VA 22313-1450
`
`Dear Sir:
`
`INTRODUCTORY COMMENTS
`
`In response to the Notice to File Corrected Application Papers dated September 19, 2017,
`
`please amend the above-identified US. patent application as follows:
`
`Amendments to the Specification begin on page 2 of this paper.
`
`Remarkszrguments begin on page 3 of this paper.
`
`66274281
`
`Lassen - Exhibit 1002, p. 16
`Lassen — Exhibit 1002, p. 16
`
`

`

`Application No.1 [5988.463
`Amendment dated September 20. 2018
`After Allowance Under 37 CFR. § L312
`
`2
`
`Docket No: M0546.700 l2USOl
`
`AMENDMENTS TO THE SPECIFICATION
`
`Please amend the Specification as follows:
`
`Please replace the paragraph starting on page 92, line 6 with the following replacement
`
`paragraph:
`
`We first generated RNA—seq data (Figure léEHfiFE—Referenee-seufee-Het—feuflde) and determined
`
`the genotype of 69 ethnically matched (Chinese) individuals in the cohort using a SNP array based
`
`on fluorescent probe hybridization supplied by Illumina (HumanOmniExpress 24).
`
`66274281
`
`Lassen - Exhibit 1002, p. 17
`Lassen — Exhibit 1002, p. 17
`
`

`

`Application N0.: 157988.463
`Amendment dated September 20. 2018
`After Allowance Under 37 CPR. § 1.312
`
`3
`
`Docket N0.: M0546.70012U301
`
`REMARKS
`
`This paper is responsive to the Notice to File Corrected Application Papers dated
`
`September 19, 2017 (“Notice").
`
`In the Notice, the Office indicated that page 92, line 6 of the
`
`specification submitted on May 24, 2018 contained the phrase “Error! Reference source not found.”
`
`By this amendment, Applicant has amended the specification to remove the phrase “Error!
`
`Reference source not found.” on page 92, line 6. No new matter has been added.
`
`Applicant believes no fee is due with this response. However, if a fee is due, please charge
`
`Deposit Account No. 2372825 under Docket No. M0546.70012US01 from which the undersigned is
`
`authorized to draw.
`
`Dated: September 20, 2018
`
`Respectfully submitted,
`
`By fAmy McMahon Kromf
`Amy McMahon Krom
`Registration N0.: 73,073
`WOLF, GREENFIELD & SACKS, PC.
`600 Atlantic Avenue
`
`Boston, Massachusetts 02210—2206
`617.646.8000
`
`66274231
`
`Lassen - Exhibit 1002, p. 18
`Lassen — Exhibit 1002, p. 18
`
`

`

`
` ”We UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Commissioner for Patents
`United States Patent and Trademark Oflioe
`PO. Box 1450
`Alexandria, VA 22313-1450
`www.uspto.gov
`
`Application No. : 15938463
`
`Applicant
`
`: Cook
`
`Filing Date : 05/24f2018
`Date Mailed : 09f19t2018
`
`NOTICE TO FILE CORRECTED APPLICATION PAPERS
`
`Notice ofA llowance Mailed
`
`This application has been accorded an Allowance Date and is being prepared for issuance. The
`application, however, is incomplete for the reasons below.
`
`Applicant is given two (2) months from the mail date of this Notice within which to respond. This
`time period for reply is extendable under 37 CFR 1.136(a) for only TWO additional MONTHS.
`
`The informalities requiring correction are indicated in the attachment(s). If the informality pertains to the
`abstract, specification (including claims) or drawings,
`the informality must be corrected with an
`amendment in compliance with 37 CFR 1.121 (or, if the application is a reissue application, 3? CFR
`1.1?3). Such an amendment may be filed after payment of the issue fee if limited to correction of
`informalities noted herein. See Waiver of 3? C FR 1.312 for Documents Required by the Office of Patent
`Publication, 1280 Off. Gaz. Patent Office 918 (March 23, 2004).
`In addition, if the informality is not
`corrected until after payment of the issue fee, for purposes of 35 U.S.C. 154(b)(l)(iv), “all outstanding
`requirements'" will be considered to have been satisfied when the informality has been corrected. A
`failure to respond within the above-identified time period will
`result
`in the application being
`ABANDONED.
`
`See attachment(s).
`
`
`A coat! of this notice MUST be returned with the repiv. Please address response to
`“Maii Stop Issue Fee, Commission erfor Patents,
`R0. Box 1450, Alexandria, VA 22313-1450”.
`
`J’Quang Nguyenf
`Publication Branch
`
`Office of Data Management
`(571) 272—4200
`
`Lassen - Exhibit 1002, p. 19
`Lassen — Exhibit 1002, p. 19
`
`

`

`Application No. 15988463
`
`IDENTIFICATION OF APPLICATION DEFICIENCIES
`
`IN APPLICATION FILED ON OR AFTER SEPTEMBER 16, 2012
`
`Applicant must provide legible text for the following item(s).
`
`
`Specification filed 12f16i’2016, page(s) 92, line 6 ("Errorl Reference source not found.".
`
`|:| Claims filed , claim(s) .
`
`D Other: .
`
`
`
`
`
`
`
`
`Applicant must provide missing information on the following page(s) of the specification by amending the
`specification to add the missing text. No new matter may be added.
`Pagei’line no(s).
`
`The specification refers to one or more applications by attorney docket number and does not show the US.
`application number(s). Applicant must supply the US. application number in place of each attorney docket
`number.
`
`Pagefline no(s).
`
`Applicant must provide an Abstract of the Disclosure.
`
`The Application Data Sheet (ADS dated ) does not supply the inventor’s city andi’or does not supply the
`inventor‘s US. state andfor does not supply the inventor's countly. Applicant must submit a signed. in
`accordance with 37 CF R l.76(e) and l.33(b), application data sheet that corrects this deficiency. To be in
`compliance with 37 CFR 1.76, the corrected application data sheet must identify the information being
`changed by using underlining for additions and strikethroughs or brackets for deletions.
`
`Odier:
`
`Lassen - Exhibit 1002, p. 20
`Lassen — Exhibit 1002, p. 20
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Docket No.: M0546.70012U801
`
`(PATENT)
`
`First Named Inventor:
`
`Stuart Alexander Cook
`
`Application No.:
`Confirmation No.:
`
`151988.463
`7597
`
`Filed:
`For:
`
`Examiner:
`
`Art Unit:
`
`May 24. 2018
`TREATMENT OF FIB ROSIS
`
`P. M. Mertz
`
`1646
`
`Certificate 01 Electronic Filing under 37 C.F.R. § 1.8
`I hereby certily that this paper (along with anyr paper referred to as being attached or enclosed) is being transmitted via the Offices electronic filing
`system in accordance with 3? C.F.Ft. § 1.6(a)(4).
`
`Electronic Signature for Nancyr .J. Arsenault: x'Nancy J. Arsenaulti'
`
`Dated: September 20. 2018
`
`RESPONSE TO NOTICE TO CORRECTED APPLICATION PAPERS
`
`Mail Stop Issue Fee
`Commissioner for Patents
`PO. Box 1450
`
`Alexandria, VA 22313-1450
`
`Dear Sir:
`
`In response to the Notice to File Corrected Application Papers mailed September 19. 2018,
`
`Applicant respectfully submits an Amendment After Allowance Under 37 CPR. §1.312 and a
`
`Copy of the Notice.
`
`Applicant believes no fee is due with this response. However. if a fee is due. please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012USO] from which the undersigned is
`
`authorized to draw.
`
`Dated: September 20, 2018
`
`Respectfully submitted.
`
`66274891
`
`By fAmy McMahon Kromi‘r
`Amy McMahon Krom
`
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS. PC.
`600 Atlantic Avenue
`
`Boston, Massachusetts 02210-2206
`617.646.8000
`
`Lassen - Exhibit 1002, p. 21
`Lassen — Exhibit 1002, p. 21
`
`

`

`Electronic Acknowledgement Receipt
`
`Application Number:
`
`15988463
`
`International Application Number:
`
`Confirmation Num ber:
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`
`
`First Named InventorIApplicant Name:
`
`Stuart Alexander Cook
`
`
`
`Filer: Amy Jeanette McMahon/Nancy Arsenault
`
`Filer Authorized By:
`
`Amy Jeanette McMahon
`
`Attorney Docket Number:
`
`M0546.70012USOI
`
`Receipt Date:
`
`20—SEP—201 8
`
`
`
`Filing Date: 24-MAY-2018
`
`Time Stamp:
`
`11:55:21
`
`Application Type:
`
`Utility under 35 USC 111(a}
`
`Payment information:
`
`Document
`
`.
`
`.
`
`.
`
`File SizelBytesl!
`
`Multi
`
`Pages
`
` Warnings:
`
`Miscellaneous Incoming Letter
`
`M054670012USO1—TRN—AM.pdf
`
`h3?car.fh36l1 {fill slam-marmnmzs 56
`d53
`
`Lassen - Exhibit 1002, p. 22
`Lassen — Exhibit 1002, o. 22
`
`

`

`Information:
`
`2
`
`M054670012U50‘I—312AMN—
`
`AMpdf
`
`951 IeaQflrtOrIiMfififich-ifiefidlftfldaficla
`_
`3562
`
`
`
`Multipart DescriptioanDF files in .zip description
`
`
`
`Amendment after Notice ofAllowance (Rule 312]
`
`
`Specification
`
`
`Applicant Arguments/Remarks Made in an Amendment
`
`Warnings:
`Information:
`
`Miscellaneous Incoming Letter
`
`M054670012 USOI -NTCAP-AM.
`pdf
`
`FIBESClZLI'FS [5.15] 313661. I dJBde I amj
`sch
`
`Warnings:
`Info rmation:
`
`Miscellaneous Incoming Letter
`
`M05467001 2USO‘I -RNTCAP-
`AMpdf
`
`55 Solid SLZWM 2 1 Cd 56b59‘d292c2v4ac8l
`
`Warnings:
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`
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`
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`
`This Acknowledgement Receipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable. It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`New Applications Under 35 U.S.C. 111
`Ifa new application is being filed and the application includes the necessary components for a filing date {see 37 CFR
`1.53{b)-[dl and MPEP 506], a Filing Receipt [37 CFR 1.54] will