UNITED STATES PATENT AND TRADEMARK OFFICE
`
`CERTIFICATE OF CORRECTION
`
`PATENT NO.
`APPLICATION NO.
`
`: 10,106,603 B2
`: 15/988463
`
`DATED
`INVENTOR(S)
`
`: October 23, 2018
`: Stuart Alexander Cooket al.
`
`Page | of 1
`
`lt is certified that error appears in the above-identified patent and that said Letters Patent is hereby corrected as shown below:
`
`In the Claims
`
`At Column 93, Claim 1, Lines 15-16, thetext:
`“A method oftreating fibrosis in the human subject, the method comprising administering to a human
`subject in”
`Should be replaced with the text:
`--A methodoftreating fibrosis in a human subject, the method comprising administering to the human
`subject in--.
`
`Signed and Sealed this
`Fifth Day of February, 2019
`
`Andrei Jancu
`Director ofthe United States Patent and Trademark Office
`
`Singapore Exhibit 2001
`Singapore Exhibit 2001
`Lassen v. Singapore et al.
`Lassen v. Singaporeetal.
`PGR2019-00053
`PGR2019-00053
`
`Ex. 2001 - Page1
`Ex. 2001 - Page‘
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARKOFFICE
`
`Docket No.: M0546.70012US01
`(PATENT)
`
`First Named Inventor:
`Application No.:
`Confirmation No.:
`Filed:
`Patent No.:
`Issued:
`For:
`Examiner:
`Art Unit:
`
`Stuart Alexander Cook
`15/988,463
`7597
`May 24, 2018
`10,106,603
`October 23, 2018
`TREATMENTOF FIBROSIS
`P. M.Mertz
`1646
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| herebycertify that this paper (along with any paperreferred to as being attached or enclosed) is being transmitted via the Office's electronic filing
`
`system in accordance with 37 C.F.R. § 1.6(a)(4). Dated: January 10, 2019
`
`Electronic Signature for Nancy J. Arsenault:
`
`/Nancy J. Arsenault/
`
`REQUEST FOR CERTIFICATE OF CORRECTION PURSUANT TO 37 CER 1.322
`
`Attention: Certificate of Correction Branch
`Commissioner for Patents
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`DearSir:
`
`Upon reviewing the above-identified patent, Patentee noted an error which should be
`
`corrected.
`
`In the Claims:
`
`At column 93, Claim 1, lines 15-16, the text:
`
`“A method oftreating fibrosis in the human subject, the method comprising administering lo
`
`a human subject in” should be replaced with the text --A method oftreating fibrosis in a human
`
`subject, the method comprising administering to the humansubjectin--.
`
`6755676.1
`
`Ex. 2001 - Page2
`Ex. 2001 - Page2
`
`

`

`Patent No.: 10,106,603
`
`2
`
`Docket No.: M0546.70012US01
`
`This error was made by the USPTO as evidenced bythe claimsin the Preliminary
`
`Amendmentfiled by Applicant on May 24, 2018 and the Examiner’s Amendmentto the claims in
`
`the Notice of Allowance dated August 3, 2018. See, in particular, claim 1 on page 3 of the
`
`Preliminary Amendmentand the Examiner’s Amendmentto claim 1 on page 2 of the Notice of
`
`Allowance. Accordingly, no fee is required.
`
`Transmitted herewith is a proposed Certificate of Correction effecting such amendment.
`
`Patentee respectfully solicits the granting of the requested Certificate of Correction.
`
`Applicant believes no fee is due with this request. However, if a fee is due, please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012US01 from which the undersigned is
`
`authorized to draw.
`
`Dated: January 10, 2019
`
`Respectfully submitted,
`
`By /Amy McMahon Krom/
`Amy McMahon Krom, PhD
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS, P.C.
`600 Atlantic Avenue
`Boston, Massachusetts 02210-2206
`617.646.8000
`
`6755676.1
`
`Ex. 2001 - Page3
`Ex. 2001 - Page3
`
`

`

`PTO/SB/44 (09-07)
`Approved for use through 01/31/2020. OMB 0651-0033
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond ta a collection of information unless it displays a valid OMB control number.
`(Also Form PTO-1050)
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`CERTIFICATE OF CORRECTION
`
`PATENT NO.
`
`:
`
`10,106,603
`
`
`
`APPLICATION NO.—: 15/988,463
`
`subject, the method comprising administering to the human subjectin--.
`
`ISSUE DATE
`
`INVENTOR(S)
`
`:
`
`:
`
`October 23, 2018
`
`Stuart Alexander Cook etal.
`
`It is certified that an error appears or errors appear in the above-identified patent and that said
`Letters Patent is hereby corrected as shown below:
`
`In the Claims:
`
`At column 93, Claim 1, lines 15-16, the text:
`
`“A method of treating fibrosis in the human subject, the method comprising administering
`to a human subject in” should be replaced with the text --A method oftreating fibrosis in a human
`
`MAILING ADDRESS OF SENDER (Please do not use Customer Number below):
`Amy McMahon Krom, PhD
`WOLF, GREENFIELD & SACKS, P.C.
`600 Atlantic Avenue
`Boston, Massachusetts 02210-2206
`
`1
`
`6755766.1
`
`Ex. 2001 - Page4
`Ex. 2001 - Page4
`
`

`

`13:20:06
`
`Title of Invention:
`
`TREATMENTOF FIBROSIS
`
`First Named Inventor/Applicant Name:
`
`Stuart Alexander Cook
`
`Customer Number:
`
`23628
`
`Amy McMahon Krom/Nancy Arsenault
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012US01
`
`Receipt Date:
`
`Filing Date:
`
`Time Stamp:
`
`10-JAN-2019
`
`24-MAY-2018
`
`Electronic AcknowledgementReceipt
`
`a s
`
`een
`
`
`
`Application Type: Utility under 35 USC 111{a)
`
`Paymentinformation:
`
`Submitted with Payment
`
`Pages
`Multi
`File Size(Bytes)/
`Document Description
`Document
`
`
`
`Number Message Digest|Part/.zip|P (if appl.)
`
`Miscellaneous Incoming Letter
`
`M054670012US01-TRN-AM. pdf; 3c2b489fb1de1d2bb89a766ab2782b5a7d
`
`2739da
`
`Ex. 2001 - Page5
`Ex. 2001 - Page5
`
`

`

`Information:
`
`Requestfor Certificate of Correction
`
`M054670012US01-RFCOC-AM.
`odf
`
`175508ef030072/ffecSaef?bal 8c1b068/ 3q
`
`Warnings:
`Information:
`
`
`
`New Applications Under 35 U.S.C. 111
`If a new applicationis being filed and the application includes the necessary componentsfora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shownon this
`Acknowledgement Receiptwill establish thefiling date of the application.
`National Stage of an International Application under 35 U.S.C. 371
`If a timely submission to enter the national stage of an international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT/DO/EO/903indicating acceptance of the application as a
`national stage submission under 35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`NewInternational Application Filed with the USPTO as a Receiving Office
`If a new international application is being filed and the international application includes the necessary componentsfor
`an international filing date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`and of the International Filing Date (Form PCT/RO/105)will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this Acknowledgement Receiptwill establish the international filing date of
`the application.
`
`
`
`Request for Certificate of Correction
`
`M054670012US01-COC-AM.pd 105b2c16591 28d7a495 | 96d2a0d429eae6i
`7991
`
`Warnings:
`Information:
`
`Total Files Size (in bytes)
`
`This AcknowledgementReceipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable.It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`Ex. 2001 - Page6
`Ex. 2001 - Page6
`
`

`

`Doc Code: TRAN.LET
`DocumentDescription: Transmittal Letter
`
`USED IN LIEU OF PTO/SB/21 (07-09)
`
`TRANSMITTAL
`FORM
`
`Issued: October 23, 2018
`Stuart Alexander Cook
`1646
`
`Art Unit
`
`(to be usedfor all correspondenceafterinitialfiling)
`P. M. Mertz
`Total Number of Pagesin This Submission|| Attomey Docket Number|nagsag70012US01
`ENCLOSURES(Checkall that apply)
`[ Fee Transmittal Form[| Drawing(s) etelowance Communication
`
`
`[| Fee Attached[| Licensing-related Papers Appeal Communication to Board
`of Appeals and Interferences
`[] Amendment/Reply
`[| Petition
`(AppealNotice, Brief, Reply Brief)
`i
`Appeal Communication to TC
`[| After Final
`Petition to Convert to a
`Proprietary Information
`Provisional Application
`[| Affidavits/declaration(s)
`Changeof Correspondence Address
`Status Letter
`Lyi
`Pawer of Attorney, Revocation
`
`Extension of Time Request[| Terminal Disclaimer x|Other Enclosure(s) (please
`Identify below):
`
`Express Abandonment Request[| Request for Refund Requestfor Certificate of
`
`Correction
`Certificate of Correction
`Information Disclosure Statement|| CD, Numberof CD(s)
`
`
`
`
`
`
`
`Certified Copy of Priority
`Landscape Table on CD
`Document(s)
`p
`
`Reply to Missing Parts/A
`Remarks
`L__] Incomplete Application
`
`
`
`/Nancy J. Arsenault/
`
`‘
`
`
`
`
`
`Reply to Missing Parts
`under 37 CFR 1.52 or 1.53
`
`WOLF, GREENFIELD & SACKS, P.C.
`
`Signaturepoe /Amy McMahon Krom/
`Printed name|amy McMahon Krom, PhD
`Date
`January 10, 2019
`
`Certificate ot Electronic Filing under 37 C.F.R. § 1.8
`| herebycertify that this paper (along with any paperreferred to as being attached or enclosed) is being transmitted via the Office's electronic
`filing system in accordance with 37 C.F.R. § 1.6(a)(4).
`
`Dated: January 10, 2019
`
`Electronic Signature for Nancy J. Arsenault:
`
`6756096.1
`
`Ex. 2001 - Page7
`Ex. 2001 - Page7
`
`

`

`PTO/SB/47 (03-09)
`Approved for use through 07/31/2018. OMB 0651-0016
`U.S. Patent and Trademark Office; U. S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unlessit displays a valid OMB control number.
`
`“FEE ADDRESS” INDICATION FORM
`
`Fax to:
`571-273-6500
`
`Addressto:
`Mail Stop M Correspondence
`Commissionerfor Patents
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`In addition,
`INSTRUCTIONS: The issue fee must have been paid for application(s) listed on this form.
`only an address represented by a Customer Number can be established as the fee address for maintenance
`fee purposes(hereafter, fee address). A fee address should be established when correspondencerelated to
`maintenancefees should be mailed to a different address than the correspondence addressfor the application.
`Whento checkthe first box below: If you have a Customer Number to represent the fee address. When
`to check the second box below: If you have no Customer Numberrepresenting the desired fee address,
`in which case a completed Request for Customer Number (PTO/SB/125) must be attached to this form. For
`more information on Customer Numbers, see the Manual of Patent Examining Procedure (MPEP) § 403.
`
`For the following listed application(s), please recognize as the “Fee Address” under the provisions of 37 CFR
`1.363 the address associated with:
`
`Customer Number:
`OR
`[| The attached Request for Customer Number (PTO/SB/125) form.
`PATENT NUMBER
`
`020016
`
`APPLICATION NUMBER
`
`(if known)- Co
`
`Completed by (check one):
`
`Applicant/Inventor
`
`Attorney or Agentof record
`
`/Brenda M. White/
`
`/Amy McMahon Krom/
`Signature
`
`73,073
`Amy McMahon Krom
`(Reg. No.)
`Typed or printed name
`Assignee of record of the entire interest. See 37 CFR 3.71.
`Statement under 37 CFR 3.73(b) is enclosed.
`61 7.646.8000
`(Form PTO/SB/96)
`Requester’s telephone number
`
`Assignee recorded at Reel
`December 14, 2018
`Date
`NOTE: Signatures of all the inventors or assignees of record of the entire interest or their representative(s) are required. Submit multiple forms if more that one
`signatureis required, see below*.
`[| * Total of
`
`Frame
`
`forms are submitted.
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| herebycertify that this paper (along with any paperreferred to as being attached or enclosed) is being transmitted via the Office's electronic filing
`system in accordance with 37 C.F.R. § 1.6(a)(4).
`
`Dated: December 14, 2018
`
`Electronic Signature for Brenda M. White:
`
`|
`
`6837861.1
`
`Ex. 2001 - Page8
`Ex. 2001 - Page8&
`
`

`

`12:54:01
`
`Title of Invention:
`
`TREATMENTOF FIBROSIS
`
`First Named Inventor/Applicant Name:
`
`Stuart Alexander Cook
`
`Customer Number:
`
`23628
`
`Amy McMahon Krom/Brenda White
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012US01
`
`Receipt Date:
`
`Filing Date:
`
`Time Stamp:
`
`14-DEC-2018
`
`24-MAY-2018
`
`Electronic AcknowledgementReceipt
`
`a s
`
`een
`
`
`
`Application Type: Utility under 35 USC 111{a)
`
`Paymentinformation:
`
`Submitted with Payment
`
`Pages
`Multi
`File Size(Bytes)/
`Document Description
`Document
`
`
`
`Number Message Digest|Part/.zip|P (if appl.)
`
`Transmittal Letter
`
`M054670012US01-TRN-AM.pdf| 604ab60c17¢101614978:.13126957aa2058)
`
`Ex. 2001 - Page9
`Ex. 2001 - Page9
`
`

`

`Warnings:
`Information:
`
`Total Files Size (in bytes)
`
`This Acknowledgement Receipt evidences receipt on the noted date by the USPTO of the indicated documents,
`characterized by the applicant, and including page counts, where applicable.It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`Information:
`
`Maintenance Fee Address Change
`
`M054670012US01-CHA-AM. pdf a68d73dc65865081d2cf200/ea1Sdb89281
`Oecde
`
`
`
`
`New Applications Under 35 U.S.C. 111
`If a new applicationis being filed and the application includes the necessary componentsfora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shownonthis
`Acknowledgement Receiptwill establish thefiling date of the application.
`
`National Stage of an International Application under 35 U.S.C. 371
`If a timely submission to enter the national stage of an international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT/DO/EO/903 indicating acceptanceof the application as a
`national stage submission under 35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`NewInternational Application Filed with the USPTO as a Receiving Office
`If a new international application is being filed and the international application includes the necessary componentsfor
`an international filing date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`andof the International Filing Date (Form PCT/RO/105)will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this Acknowledgement Receiptwill establish the international filing date of
`the application.
`
`Ex. 2001 - Page10
`Ex. 2001 - Page10
`
`

`

`Doc Code: TRAN.LET
`DocumentDescription: Transmittal Letter
`
`TRANSMITTAL
`FORM
`
`USED IN LIEU OF PTO/SB/21 (07-09)
`
`Issued: October 23, 2018
`
`(to be usedfor all correspondenceafterinitial filing)
`
`Examiner Name
`
`P.M. Mertz
`
`/Brenda M. White/
`
`
`
`
`
`
`
`
`ENCLOSURES(Checkall that apply)
`Drawing(s)
`[ Fee Transmittal Form
`[ nieeAlowance Communication
`
`[] Fee Attached Licensing-related Papers [ Appeal Communication to Board
`
`of Appeals and Interferences
`L Amendment/Reply
`Petition
`[| (Appeal Notice, Briet, Reply Brief)
`i
`Appeal Communication to TC
`
`[] After Final Petition to Convert to a [ Proprietary Information
`
`LJ Provisional Application
`
`[| Powerof Attorney, Revocation[] Affidavits/declaration(s) L_| change of Correspondence Address Status Letter
`
`Shea
`:
`[| Extension of Time Request
`Terminal Disclaimer
`[x] Other Enclosure(s) (please
`Identify below):
`[| Express Abandonment Request
`Request for Refund
`Fee AddressIndication Form
`[| Information Disclosure Statement
`CD, Numberof CD(s)
`[| Certified Copy of Priority
`[] Landscape Table on CD
`Document(s)
`Reply to Missing Parts/
`Incomplete Application
`
`
`
`Reply to Missing Parts
`under 37 CFR 1.52 or 1.53
`
`WOLF, GREENFIELD & SACKS, P.C.
`
`SignaturePoe|/Amy McMahon Krom/
`or
`rinted name Amy McMahon Krom
`
`Date
`December14, 2018
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| hereby certify that this paper (along with any paperreferred to as being attached or enclosed) is being transmitted via the Office's electronic
`filing system in accordance with 37 C.F.R. § 1.6(a)(4).
`
`Dated: December 14, 2018
`
`Electronic Signature for Brenda M. White:
`
`6837857.1
`
`Ex. 2001 - Page11
`Ex. 2001 - Page11
`
`

`

`To:
`From:
`Cc:
`Subject:
`
`Patents_eOfficeAction@WolfGreenfield.com,WGS_eOfficeAction@WolfGreenfield.com,
`PAIR_eOfficeAction@uspto.gov
`PAIR_eOfficeAction@uspto.gov
`Private PAIR Correspondence Notification for Customer Number 23628
`
`Oct 04, 2018 04:51:20 AM
`
`Dear PAIR Customer:
`
`WOLF GREENFIELD & SACKS, P.C.
`600 ATLANTIG AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES
`
`The following USPTO patent application(s) associated with your Customer Number, 23628 , have
`new outgoing correspondence. This correspondence is now available for viewing in Private PAIR.
`
`The official date of notification of the outgaing correspondencewill be indicated on the form PTOL-90
`accompanying the correspondence.
`
`Disclaimer:
`The list of documents shownbelow is provided as a courtesy andis not partof the official file
`wrapper. The content of the images shown in PAIR is the official record.
`
`Application
`15988463
`
`Document
`ISSUE.NTF
`
`Mailroom Date
`10/03/2018
`
`Attorney Docket No.
`M0546.70012US01
`
`To view your correspondenceonline or update your email addresses, please visit us anytime at
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`PATENT APPLICATION INFORMATION RETRIEVAL SYSTEM
`
`Ex. 2001 - Page12
`Ex. 2001 - Page12
`
`

`

`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address: COMMISSIONER FOR PATENTS
`P.O. Box 1450
`Alexandria, Virginia 22313-1450
`www.uspto.gov
`
`APPLICATION NO.
`
`15/988 ,463
`
`ISSUE DATE
`
`10/23/2018
`
`PATENT NO.
`
`10106603
`
`ATTORNEY DOCKET NO.
`
`CONFIRMATION NO.
`
`M0546.70012US01
`
`7597
`
`23628
`
`7590
`
`10/03/2018
`
`WOLFE GREENFIELD & SACKS, P.C.
`600 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES OF AMERICA
`
`The projected patent numberandissue date are specified above.
`
`ISSUE NOTIFICATION
`
`Determination of Patent Term Adjustment under 35 U.S.C. 154 (b)
`(application filed on or after May 29, 2000)
`
`The Patent Term Adjustmentis 0 day(s). Any patent to issue from the above-identified application will include
`an indication of the adjustmenton the front page.
`
`If a Continued Prosecution Application (CPA) wasfiled in the above-identified application, the filing date that
`determines Patent Term Adjustmentis the filing date of the most recent CPA.
`
`Applicant will be able to obtain more detailed information by accessing the Patent Application Information
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`(ODM)at (571)-272-4200.
`
`APPLICANT(s) (Please see PAIR WEBsite http://pair.uspto.gov for additional applicants):
`
`Stuart Alexander Cook, Singapore, SINGAPORE;
`Singapore Health Services PTE LTD., Singapore, SINGAPORE;
`National University of Singapore, Singapore, SINGAPORE;
`Sebastian Schaefer, Singapore, SINGAPORE;
`
`The United States represents the largest, most dynamic marketplace in the world and is an unparalleled location
`for business investment, innovation, and commercialization of new technologies. The USA offers tremendous
`resources and advantages for those who invest and manufacture goods here. Through SelectUSA, our nation
`worksto encourage andfacilitate business investment. To learn more about why the USAis the best country in
`the world to develop technology, manufacture products, and grow your business, visit SelectUSA. gov.
`
`IR103 (Rey. 10/09)
`
`Ex. 2001 - Page13
`Ex. 2001 - Page13
`
`

`

`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and TrademarkOffice
`Address: COMMISSIONER FOR PATENTS
`P.O. Box 1450
`Alexandria, Virginia 22313-1450
`www.uspto.gov
`
`APPLICATION NO.
`
`FILING DATE
`
`FIRST NAMED INVENTOR
`
`ATTORNEY DOCKETNO.
`
`CONFIRMATION NO.
`
`15/988,463
`
`05/24/2018
`
`Stuart Alexander Cook
`
`M0546.70012US01
`
`7597
`
`WOLF GREENFIELD & SACKS, P.C.
`
`600 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES OF AMERICA
`
`[never]
`
`MERTZ, PREMA MARIA
`
`1646
`
`NOTIFICATION DATE
`
`DELIVERY MODE
`
`09/25/2018
`
`ELECTRONIC
`
`Please find below and/or attached an Office communication concerning this application or proceeding.
`
`Thetime period for reply, if any, is set in the attached communication.
`
`Notice of the Office communication was sent electronically on above-indicated "Notification Date" to the
`following e-mail address(es):
`Patents_eOfficeAction@WolfGreenfield.com
`WGS_eOfficeAction@WolfGreenfield.com
`
`PTOL-90A (Rev. 04/07)
`
`Ex. 2001 - Page14
`Ex. 2001 - Page14
`
`

`

`Application No.
`Applicant(s)
`15/988 463
`
`Response to Rule 312 Communication
`An Unit
`
`
`
`
`
`
`
`
`
`-- The MAILING DATEofthis communication appears on the cover sheet with the correspondenceaddress —
`
`1. K] The amendmentfiled on 20 September 2018 under 37 CFR 1.312 has been considered, and has been:
`
`a) K) entered.
`
`b) entered as directed to matters of form not affecting the scope ofthe invention.
`
`c)) disapproved because the amendmentwasfiled after the paymentofthe issue fee.
`Any amendmentfiled after the date the issue fee is paid must be accompanied by a petition under 37 CFR 1.313(c)(1) and
`the required fee to withdraw the application from issue.
`
`
`
`
`
`
`d)( disapproved. See explanation below.
`
`e) ( entered in part. See explanation below.
`
`CHilliard
`
`U.S. Palent and Trademark Office
`PTOL-271 (Rev. 04-01)
`
`Reponseto Rule 312 Communication
`
`Part of Paper No.
`
`Ex. 2001 - Page15
`Ex. 2001 - Page15
`
`

`

`To:
`From:
`Cc:
`Subject:
`
`Patents_eOfficeAction@WolfGreenfield.com,WGS_eOfficeAction@WolfGreenfield.com,
`PAIR_eOfficeAction@uspto.gov
`PAIR_eOfficeAction@uspto.gov
`Private PAIR Correspondence Notification for Customer Number 23628
`
`Sep 25, 2018 03:35:28 AM
`
`Dear PAIR Customer:
`
`WOLF GREENFIELD & SACKS, P.C.
`600 ATLANTIG AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES
`
`The following USPTO patent application(s) associated with your Customer Number, 23628 , have
`new outgoing correspondence. This correspondence is now available for viewing in Private PAIR.
`
`The official date of notification of the outgaing correspondencewill be indicated on the form PTOL-90
`accompanying the correspondence.
`
`Disclaimer:
`The list of documents shownbelow is provided as a courtesy andis not partof the official file
`wrapper. The content of the images shown in PAIR is the official record.
`
`Application
`15988463
`
`Document
`N271
`
`Mailroom Date
`09/25/2018
`
`Attorney Docket No.
`M0546.70012US01
`
`To view your correspondenceonline or update your email addresses, please visit us anytime at
`https ://sportal.uspto.gov/secure/myportal/privatepair.
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`
`Thank you for promptattention to this notice,
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`PATENT APPLICATION INFORMATION RETRIEVAL SYSTEM
`
`Ex. 2001 - Page16
`Ex. 2001 - Page 16
`
`

`

`To:
`From:
`Cc:
`Subject:
`
`Patents_eOfficeAction@WolfGreenfield.com,WGS_eOfficeAction@WolfGreenfield.com,
`PAIR_eOfficeAction@uspto.gov
`PAIR_eOfficeAction@uspto.gov
`Private PAIR Correspondence Notification for Customer Number 23628
`
`Sep 21, 2018 04:10:24 AM
`
`Dear PAIR Customer:
`
`WOLF GREENFIELD & SACKS, P.C.
`600 ATLANTIG AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES
`
`The following USPTO patent application(s) associated with your Customer Number, 23628 , have
`new outgoing correspondence. This correspondence is now available for viewing in Private PAIR.
`
`The official date of notification of the outgaing correspondencewill be indicated on the form PTOL-90
`accompanying the correspondence.
`
`Disclaimer:
`The list of documents shownbelow is provided as a courtesy andis not partof the official file
`wrapper. The content of the images shown in PAIR is the official record.
`
`Application
`15988463
`
`Document
`NTC.PUB
`
`Mailroom Date
`09/20/2018
`
`Attorney Docket No.
`M0546.70012US01
`
`To view your correspondenceonline or update your email addresses, please visit us anytime at
`https ://sportal.uspto.gov/secure/myportal/privatepair.
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`If you have any questions, please email the Electronic Business Center (EBC) at EBC@uspto.gov
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`Monday- Friday 6:00 a.m. to 12:00 a.m.
`
`Thank you for promptattention to this notice,
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`PATENT APPLICATION INFORMATION RETRIEVAL SYSTEM
`
`Ex. 2001 - Page17
`Ex. 2001 - Page17
`
`

`

`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`
` APPLICATION NUMBER FILING OR 371(C) DATE FIRST NAMED APPLICANT ATTY. DOCKET NO./TITLE
`
`
`
`TINITED STATES DEPARTMENT OF COMMERCE
`United States Patent and 'lrademarkOffice
`Address: COMMTSSIONER, FOR PATENTS
`P.C. Box 1450
`Alexandria, Virgnia 22313-1450
`Wwww.uspto.gov
`
`
`15/988,463
`05/24/2018
`Stuart Alexander Cook
`M0546.70012US01
`CONFIRMATION NO. 7597
`PUBLICATION NOTICE
`
`23628
`WOLF GREENFIELD & SACKS, P.C.
`
`600 ATLANTIC AVENUE
`
`BOSTON, MA 02210-2206
`
`AMATAEA000000102465979
`
`Title:TREATMENT OF FIBROSIS
`
`Publication No.US-2018-0265579-A1
`Publication Date:09/20/2018
`
`NOTICE OF PUBLICATION OF APPLICATION
`
`The above-identified application will be electronically published as a patent application publication pursuant to 37
`CFR 1.211, et seq. The patent application publication number and publication date are set forth above.
`
`The publication may be accessed through the USPTO's publically available Searchable Databases via the
`Internet at www.uspto.gov. The direct link to access the publication is currently http:/Awww.uspto.gov/pattt/.
`
`The publication process established by the Office does not provide for mailing a copy of the publication to
`applicant. A copy of the publication may be obtained from the Office upon paymentof the appropriate fee set
`forth in 37 CFR 1.19(a)(1). Orders for copies of patent application publications are handled by the USPTO's
`Public Records Division. The Public Records Division can be reachedby telephone at (571) 272-3150 or (800)
`972-6382, by facsimile at (571) 273-3250, by mail addressed to the United States Patent and TrademarkOffice,
`Public Records Division, Alexandria, VA 22313-1450 or via the Internet.
`
`In addition, information on the status of the application, including the mailing date of Office actions and
`the dates of receipt of correspondencefiled in the Office, may also be accessedvia the Internet through
`the Patent Electronic Business Center at www.uspto.gov using the public side of the Patent Application
`Information and Retrieval (PAIR) system. The directlink to access this status information is currently
`https://portal.uspto.gov/pair/PublicPair. Prior to publication, such status information is confidential and may only
`be obtained by applicant using the private side of PAIR.
`
`Further assistance in electronically accessing the publication, or about PAIR, is available by calling the Patent
`Electronic Business Center at 1-866-217-9197.
`
`
`
`Office of Data Managment, Application Assistance Unit (571) 272-4000, or (571) 272-4200, or 1-888-786-0101
`
`page 1 of 1
`
`Ex. 2001 - Page18
`Ex. 2001 - Page18
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARKOFFICE
`
`Docket No.: M0546.70012US01
`(PATENT)
`
`First Named Inventor:
`Application No.:
`Confirmation No.:
`Filed:
`For:
`Examiner:
`Art Unit:
`
`Stuart Alexander Cook
`15/988,463
`7597
`May 24, 2018
`TREATMENTOFFIBROSIS
`P. M. Mertz
`1646
`
`Dated: September20, 2018 Electronic Signature for Nancy J. Arsenault:
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| herebycertify that this paper (along with any paperreferred to as being attached or enclosed) is being transmitted via the Office's electronic filing
`system in accordance with 37 C.F.R. § 1.6(a}(4).
`
`/Nancy J. Arsenault/
`
`
`
`AMENDMENT AFTER ALLOWANCE UNDER37 C.E.R.§ 1.312
`
`Mail Stop Issue Fee
`Commissioner for Patents
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`Dear Sir:
`
`INTRODUCTORY COMMENTS
`
`In response to the Notice to File Corrected Application Papers dated September 19, 2017,
`
`please amendthe above-identified U.S. patent application as follows:
`
`Amendments to the Specification begin on page 2 of this paper.
`
`Remarks/Arguments begin on page 3 of this paper.
`
`6627428 1
`
`Ex. 2001 - Page19
`Ex. 2001 - Page19
`
`

`

`Application No.: 15/988,463
`Amendmentdated September 20, 2018
`After Allowance Under 37 C.F.R. § 1.312
`
`2
`
`Docket No.: M0546.70012US01
`
`AMENDMENTS TO THE SPECIFICATION
`
`Please amendthe Specification as follows:
`
`Please replace the paragraph starting on page 92, line 6 with the following replacement
`
`paragraph:
`
`Wefirst generated RNA-seq data (Figure 16Errer!}Referenee-seurcenetfeund.) and determined
`
`the genotype of 69 ethnically matched (Chinese) individuals in the cohort using a SNParray based
`
`on fluorescent probe hybridization supplied by lumina (HumanOmniExpress 24).
`
`6627428 1
`
`Ex. 2001 - Page20
`Ex. 2001 - Page20
`
`

`

`Application No.: 15/988,463
`Amendmentdated September 20, 2018
`After Allowance Under 37 C.F.R. § 1.312
`
`3
`
`Docket No.: M0546.70012US01
`
`REMARKS
`
`This paper is responsive to the Notice to File Corrected Application Papers dated
`
`September 19, 2017 (“Notice”). In the Notice, the Office indicated that page 92,line 6 of the
`
`specification submited on May 24, 2018 contained the phrase “Error! Reference source not found.”
`
`By this amendment, Applicant has amendedthe specification to remove the phrase “Error!
`
`Reference source not found.” on page 92, line 6. No new matter has been added.
`
`Applicant believes no fee is due with this response. However,if a fee is due, please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012US01 from which the undersigned is
`
`authorized to draw.
`
`Dated: September 20, 2018
`
`Respectfully submitted,
`
`By /Amy McMahon Krom/
`Amy McMahon Krom
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS, P.C.
`600 Atlantic Avenue
`Boston, Massachusetts 02210-2206
`617.646.8000
`
`6627428 1
`
`Ex. 2001 - Page21
`Ex. 2001 - Page21
`
`

`

`
`
`Commissionerfor Patents
`United States Patent and Trademark Office
`P.O. Box 1450
`Alexandria, VA 22313-1450
`www.uspto.gov
`
`Application No. | 15988463
`Applicant
`: Cook
`Filing Date : 05/24/2018
`Date Mailed : 09/19/2018
`
`NOTICE TO FILE CORRECTED APPLICATION PAPERS
`
`Notice ofAllowance Mailed
`
`This application has been accorded an Allowance Date and is being prepared for issuance.
`application, however, is incomplete for the reasons below.
`
`The
`
`Applicant is given two (2) months from the mail date of this Notice within which to respond. This
`time period for reply is extendable under 37 CFR 1.136(a) for only TWO additional MONTHS.
`
`The informalities requiring correction are indicated in the attachment(s). Ifthe informality pertains to the
`abstract, specification (including claims) or drawings,
`the informality must be corrected with an
`amendment in compliance with 37 CFR 1.121 (or, if the application is a reissue application, 37 CFR
`1.173). Such an amendment maybe filed after payment of the issue fee if limited to correction of
`informalities noted herein. See Waiver of 37 CFR 1.312 for Documents Required by the Office of Patent
`Publication, 1280 Off. Gaz. Patent Office 918 (March 23, 2004).
`In addition, if the informality is not
`corrected until after payment of the issue fee, for purposes of 35 U.S.C. 154(b)(1)(@v), “all outstanding
`requirements” will be considcred to have becn satisficd when the informality has becn corrected. A
`failure to respond within the above-identified time period will
`result
`in the application being
`ABANDONED.
`
`See attachment(s).
`
`A copy ofthis notice MUSTbe returned with the reply. Please address response to
`“Mail Stop Issue Fee, Commissionerfor Patents,
`P.O. Box 1450, Alexandria, VA 22313-1450”.
`
`/Quang Nguyen/
`Publication Branch
`Office of Data Management
`(571) 272-4200
`
`Ex. 2001 - Page22
`Ex. 2001 - Page22
`
`

`

`Application No. 15988463
`
`IDENTIFICATION OF APPLICATION DEFICIENCIES
`IN APPLICATION FILED ON OR AFTER SEPTEMBER 16, 2012
`
`Applicant must provide legible text for the following item(s).
`
`
`X|
`
`
`
`
`
`Specification filed 12/16/2016, page(s) 92, line 6 (Error! Reference source not found.".
`
`Claimsfiled , claim(s) .
`
`Other: .
`
`
`
`[ Applicant must provide missing information on the following page(s) of the specification by amending the
`specification to add the missing text. No new matter maybe added.
`Page/line no(s).
`
`[ The specification refers to one or more applications by attorney docket number and does not show the