UNITED STATES PATENT AND TRADEMARK OFFICE
`CERTIFICATE OF CORRECTION
`
`PATENT NO.
`APPLICATION NO.
`
`- 10,106,603 B2
`: 15/988463
`
`DATED
`INVENTOR(S)
`
`: October 23, 2018
`: Stuart Alexander Cooketal.
`
`Page 1 of 1
`
`It is certified that error appears in the above-identified patent and that said Letters Patent is hereby corrected as shown below:
`
`In the Claims
`
`At Column 93, Claim 1, Lines 15-16, the text:
`“A methodoftreating fibrosis in the human subject, the method comprising administering to a human
`subject in”
`Should be replaced with the text:
`--A methodoftreating fibrosis in a human subject, the method comprising administering to the human
`subject in--.
`
`Pree Arr—
`
`Signed and Sealed this
`Fifth Day of February, 2019
`
`Andrei Iancu
`
`Director ofthe United States Patent and Trademark Office
`
`Lassen - Exhibit 1002, p. 1
`Lassen - Exhibit 1002, p. 1
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Docket No.: M0546.70012US01
`(PATENT)
`
`First Named Inventor:
`Application No.:
`Confirmation No.:
`Filed:
`Patent No.:
`Issued:
`For:
`Examiner:
`Art Unit:
`
`Stuart Alexander Cook
`15/988,463
`7597
`May 24, 2018
`10,106,603
`October 23, 2018
`TREATMENTOFFIBROSIS
`P. M. Mertz
`1646
`
`/Nancy J. Arsenault/
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| hereby certify that this paper (along with any paper referred to as being attached or enclosed)is being transmitted via the Office's electronic filing
`system in accordance with 37 C.F.R. § 1.6(a)(4).
`
`Dated: January 10, 2019
`
`Electronic Signature for Nancy J. Arsenault:
`
`REQUEST FOR CERTIFICATE OF CORRECTION PURSUANT TO 37 CER 1.322
`
`Attention: Certificate of Correction Branch
`Commissionerfor Patents
`
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`Dear Sir:
`
`Upon reviewing the above-identified patent, Patentee noted an error which should be
`
`corrected.
`
`In the Claims:
`
`At column 93, Claim 1, lines 15-16, the text:
`
`“A method of treating fibrosis in the human subject, the method comprising administering to
`
`a human subject in” should be replaced with the text --A method oftreating fibrosis in a human
`
`subject, the method comprising administering to the human subjectin--.
`
`6755676.1
`
`Lassen - Exhibit 1002, p. 2
`Lassen - Exhibit 1002, p. 2
`
`

`

`Patent No.: 10,106,603
`
`2
`
`Docket No.: M0546.70012US01
`
`This error was made by the USPTOas evidenced bythe claims in the Preliminary
`
`Amendmentfiled by Applicant on May 24, 2018 and the Examiner’s Amendmentto the claimsin
`
`the Notice of Allowance dated August 3, 2018. See, in particular, claim 1 on page 3 of the
`
`Preliminary Amendmentand the Examiner’s Amendmentto claim | on page 2 of the Notice of
`
`Allowance. Accordingly, no fee is required.
`
`Transmitted herewith is a proposed Certificate of Correction effecting such amendment.
`
`Patentee respectfully solicits the granting of the requested Certificate of Correction.
`
`Applicant believes no fee is due with this request. However, if a fee is due, please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012US01 from which the undersigned is
`
`authorized to draw.
`
`Dated: January 10, 2019
`
`Respectfully submitted,
`
`By /Amy McMahon Krom/
`Amy McMahon Krom, PhD
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS, P.C.
`600 Atlantic Avenue
`Boston, Massachusetts 02210-2206
`617.646.8000
`
`6755676.1
`
`Lassen - Exhibit 1002, p. 3
`Lassen - Exhibit 1002, p. 3
`
`

`

`PTO/SB/44 (09-07)
`Approved for use through 01/31/2020. OMB 0651-0033
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unlessit displays a valid OMB control number.
`(Also Form PTO-1050'
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`CERTIFICATE OF CORRECTION
`
`Page _1_of_i.
`
`PATENTNO.
`
`APPLICATION NO.
`
`ISSUE DATE
`
`:
`
`:
`
`:
`
`10,106,603
`
`15/988,463
`
`October 23, 2018
`
`INVENTOR(S)
`
`:
`
`Stuart Alexander Cook etal.
`
`subject, the method comprising administering to the human subjectin--.
`
`It is certified that an error appears or errors appearin the above-identified patent and that said
`Letters Patent is hereby corrected as shown below:
`
`In the Claims:
`
`At column 93, Claim 1, lines 15-16, the text:
`
`“A method oftreating fibrosis in the human subject, the method comprising administering
`to a humansubject in” should be replaced with the text --A method oftreating fibrosis in a human
`
`MAILING ADDRESS OF SENDER (Please do not use Customer Number below):
`Amy McMahon Krom, PhD
`WOLF, GREENFIELD & SACKS, P.C.
`600 Atlantic Avenue
`Boston, Massachusetts 02210-2206
`
`1
`
`6755766.1
`Lassen - Exhibit 1002, p. 4
`Lassen - Exhibit 1002, p. 4
`
`

`

`Electronic AcknowledgementReceipt
`
`Application Number:
`
`15988463
`
`Confirmation Number:
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`First Named Inventor/Applicant Name:
`
`Stuart Alexander Cook
`
`International Application Number:
`
`
`
`
`
`Filer: Amy McMahon Krom/Nancy Arsenault
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012US01
`
`Receipt Date:
`
`10-JAN-2019
`
`
`
`Filing Date: 24-MAY-2018
`
`Time Stamp:
`
`13:20:06
`
`Application Type:
`
`Utility under 35 USC 11 1{a)
`
`Paymentinformation:
`
` Warnings:
`
`Document
`
`eae
`
`5
`
`File Size(Bytes)/
`Message Digest
`
`Multi
`
`Pages
`(if appl.)
`
`Miscellaneous Incoming Letter
`
`M054670012US01-TRN-AM.pdf
`
`AQbDiaHbideld2bbSia766ab27a2bSard
`
`Lassen - Exhibit 1002, p. 5
`Lassen - Exhibit 1002, p. 5
`
`

`

`Information:
`
`M054670012US01-RFCOC-AM.
`pdf
`Requestfor Certificate of Correction
`
`
`175508e(0300724fechael? balac 1bO6a43
`
`Warnings:
`
`Information:
`
`the application.
`
`New Applications Under 35 U.S.C.111
`If a new applicationis being filed and the application includes the necessary componentsfora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shownonthis
`AcknowledgementReceiptwill establish thefiling date of the application.
`NationalStageof an International Application under 35 U.S.C. 371
`If a timely submission to enter the national stage of an international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT/DO/EO/903indicating acceptance of the application asa
`national stage submission under35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`New International Application Filed with the USPTO as a Receiving Office
`If a new international application is being filed and the international application includes the necessary componentsfor
`an internationalfiling date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`and ofthe International Filing Date (Form PCT/RO/105)will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this AcknowledgementReceiptwill establish the internationalfiling date of
`
`M054670012US01-COC-AM.pd 1055216591 28d70495 1 96d 2a0d429eae6)
`7991
`
`
`Request for Certificate of Correction
`
`Warnings:
`
`Information:
`
`TotalFiles Size (in bytes)
`
`This AcknowledgementReceipt evidences receipt on the noted date by the USPTO ofthe indicated documents,
`characterized by the applicant, and including page counts, where applicable.It serves as evidence of receipt similar toa
`Post Card, as described in MPEP 503.
`
`Lassen - Exhibit 1002, p. 6
`Lassen - Exhibit 1002, p. 6
`
`

`

`ENCLOSURES(Checkall that apply)
` || Drawing(s)
`
`
` [| Fee Attached|| Licensing-related Papers
`
` || Petition
`
`
`[ After Final
`| Proprietary Information
`[| Affidavits/declaration(s}
`| Status Letter
`|| Terminal Disclaimer
`|| Request for Refund
`Requestfor Certificate of
`Correction
`Certificate of Correction
`|| CD, Numberof CD(s)
`
` Landscape Table on CD
`
`/Nancy J. Arsenault/
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Doc Code: TRAN.LET
`Document Description: Transmittal Letter
`
`USED IN LIEU OF PTO/SB/21 (07-09)
`
`TRANSMITTAL
`FORM
`
`Filing Date
`
`Fitst Nemed Inventor
`
`Patent#: 10,106,603
`
`Issued: October 23, 2018
`Stuart Alexander Cook
`
`(to be used for all correspondenceafterinitialfiling)
`
`Examiner Name
`
`P. M. Mertz
`
`Total Number of Pages in This Submission
`
`
`
`Fee Transmittal Form
`
`Amendment/Reply
`
`Extension of Time Request
`
`Express Abandonment Request
`
`Information Disclosure Statement
`
`Certified Copy of Priority
`Document(s)
`
`
`
`Petition to Convert to a
`Provisional Application
`
`Power of Attorney, Revocation
`Change of Correspondence Address
`
`After Allowance Communication
`to TC
`
`Appeal Communication to Board
`of Appeals andInterferences
`
`Appeal Communication to TC
`(Appeal Notice, Brief, Reply Brief)
`
`Other Enclosure(s)} (please
`Identify below):
`
`
`
`
`
`
`
`
`
`Reply to Missing Parts/
`J Incomplete Application
`
`Reply to Missing Parts
`under 37 CFR 1.52 or 1.53
`
`SIGNATURE OF APPLICANT, ATTORNEY, OR AGENT
`
`WOLF, GREENFIELD & SACKS, P.C.
`
`Signatureee
`Printed name
`Amy McMahon Krom, PhD
`
`Date
`January 10, 2019
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| hereby certify that this paper (along with any paperreferred to as being attached or enclosed) is being transmitted via the Office's electronic
`filing system in accordance with 37 G.F.R. § 1.6(a)(4).
`
`Dated: January 10, 2019
`
`Electronic Signature for Nancy J. Arsenault:
`
`6756096.1
`Lassen - Exhibit 1002, p. 7
`Lassen - Exhibit 1002, p. 7
`
`

`

`PTO/SB/47 (03-09)
`Approved for use through 07/31/2018. OMB 0651-0016
`U.S. Patent and Trademark Office; U. S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it displays a valid OMB control number.
`
`“FEE ADDRESS” INDICATION FORM
`
`Fax to:
`571-273-6500
`
`Address to:
`Mail Stop M Correspondence
`Commissionerfor Patents
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`In addition,
`INSTRUCTIONS: The issue fee must have been paid for application(s) listed on this form.
`only an address represented by a Customer Number can be established as the fee address for maintenance
`fee purposes (hereafter, fee address). A fee address should be established when correspondencerelated to
`maintenance fees should be mailed to a different address than the correspondenceaddressfor the application.
`Whento checkthefirst box below: If you have a Customer Number to represent the fee address. When
`to check the second box below: If you have no Customer Numberrepresenting the desired fee address,
`in which case a completed Request for Customer Number (PTO/SB/125) mustbe attached to this form. For
`more information on Customer Numbers, see the Manual of Patent Examining Procedure (MPEP) § 403.
`
`For the following listed application(s), please recognize as the “Fee Address” under the provisions of 37 CFR
`1.363 the address associated with:
`
`Customer Number:
`OR
`[| The attached Request for Customer Number (PTO/SB/125) form.
`
`020016
`
`APPLICATION NUMBER
`PATENT NUMBER
`(if Known)
`
`10,106,603
`
`Completed by (check one):
`Applicant/Inventor
`
`
`/Amy McMahon Krom/
`Signature
`
`/Brenda M. White/
`
`forms are submitted.
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| hereby certify that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic filing
`system in accordance with 37 G.F.R. § 1.6(a)({4).
`
`Dated: December 14, 2018
`
`Electronic Signature for Brenda M. White:
`
`1
`
`6837861.1
`Lassen - Exhibit 1002, p. 8
`Lassen - Exhibit 1002, p. 8
`
`Riormeyondiganiotrecord
`
`73,073
`(Reg. No.)
`Assignee of record of the entire interest. See 37 CFR 3.71.
`Statement under 37 CFR 3.73(b) is enclosed.
`(Form PTO/SB/96)
`Assignee recorded at Reel
`
`Frame
`
`Amy McMahon Krom
`Typed or printed name
`617.646.8000
`:
`Requester's telephone number
`December 14, 2018
`Date
`NOTE: Signaturesofall the inventors or assignees of record of the entire interest or their representative(s) are required. Submit multiple forms if more that one
`signature is required, see below’.
`[| * Total of
`
`

`

`Electronic AcknowledgementReceipt
`
`Application Number:
`
`15988463
`
`Confirmation Number:
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`First Named Inventor/Applicant Name:
`
`Stuart Alexander Cook
`
`International Application Number:
`
`
`
`
`
`Filer: Amy McMahon Krom/Brenda White
`
`Filer Authorized By:
`
`Amy McMahon Krom
`
`Attorney Docket Number:
`
`M0546.70012US01
`
`Receipt Date:
`
`14-DEC-2018
`
`
`
`Filing Date: 24-MAY-2018
`
`Time Stamp:
`
`12:54:01
`
`Application Type:
`
`Utility under 35 USC 11 1{a)
`
`Paymentinformation:
`
` Warnings:
`
`Document
`
`eae
`
`5
`
`File Size(Bytes)/
`Message Digest
`
`Multi
`
`Pages
`(if appl.)
`
`Transmittal Letter
`
`M054670012US01-TRN-AM.pdf
`
`604ab60c17c10161497ac 13126957aa2056
`
`Lassen - Exhibit 1002, p. 9
`Lassen - Exhibit 1002, p. 9
`
`

`

`Information:
`
`Maintenance Fee Address Change
`
`M054670012US01-CHA-AM. pdf a6dd73dc65865084d2cf20M4ea4 5d b89281
`Decte
`
`
`
`TotalFiles Size (in bytes)
`
`Warnings:
`
`Information:
`
`This AcknowledgementReceipt evidences receipt on the noted date by the USPTOof the indicated documents,
`characterized by the applicant, and including page counts, where applicable.It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`
`New Applications Under 35 U.S.C. 111
`If a new application is being filed and the application includes the necessary componentsfora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shownonthis
`AcknowledgementReceiptwill establish thefiling date of the application.
`
`National Stage of an International Application under 35 U.S.C. 371
`If a timely submission to enter the national stage of an international application is compliant with the conditions of 35
`U.S.C. 371 and other applicable requirements a Form PCT/DO/EO/903 indicating acceptance of the application asa
`national stage submission under35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`New International Application Filed with the USPTO as a Receiving Office
`If a new international application is being filed and the international application includes the necessary componentsfor
`an international filing date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`and ofthe InternationalFiling Date (Form PCT/RO/105)will be issued in due course, subject to prescriptions concerning
`national security, and the date shownon this Acknowledgement Receiptwill establish the internationalfiling date of
`the application.
`
`
`
`Lassen - Exhibit 1002, p. 10
`Lassen - Exhibit 1002, p. 10
`
`

`

`Doc Code: TRAN.LET
`Document Description: Transmittal Letter
`
`TRANSMITTAL
`FORM
`
`USED IN LIEU OF PTO/SB/21 (07-09)
`
`Filing Date
`
`Firat Named Inveror
`
`Patent#: 10,106,603
`
`Issued: October 23, 2018
`Stuart Alexander Cook
`
`(to be usedfor all correspondence afterinitialfiling)
`
`
`Total Number of Pages in This Submission
`
` | CD, Numberof CD(s)
`
`After Allowance Communication
`to TC
`
`Appeal Communication to Board
`of Appeals and Interferences
`
`Appeal Communication to TC
`(Appeal Notice, Brief, Reply Brief)
`
`[| Proprietary Information
`[| Status Letter
`
`Other Enclosure(s} (please
`Identify below):
`
`Fee Address Indication Form
`
`ENCLOSURES(Checkall that apply)
` a Fee Transmittal Form
`| Drawing(s)
`
`|| Fee Attached | Licensing-related Papers
`[| Amendment/Reply
`| Petition
`[| ater Final
`[| Affidavits/declaration(s)
`[| Extension of Time Request
`[| Express Abandonment Request
`[| Information Disclosure Statement
`Certified Copyof Priority
`
`/Brenda M. White/
`
`Petition to Convert to a
`Provisional Application
`
`Powerof Attorney, Revocation
`Change of Correspondence Address
`
`| Terminal Disclaimer
`| Request for Refund
`
` Landscape Table on CD
`[_]
`
`
`
`Document(s)
`
`Reply to Missing Parts/
`Incomplete Application
`
`Reply to Missing Parts
`under 37 CFR 1.52 or 1.53
`
`SIGNATURE OF APPLICANT, ATTORNEY, OR AGENT
`
`WOLF, GREENFIELD & SACKS, P.C.
`
`Signature| /Amy McMahon Krom/
`Printed name
`Amy McMahon Krom
`
`ae
`December14, 2018
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| hereby certify that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic
`filing system in accordance with 37 C.F.R. § 1.6(a)(4).
`
`Dated: December 14, 2018
`
`Electronic Signature for Brenda M. White:
`
`6837857.1
`Lassen - Exhibit 1002, p. 11
`Lassen - Exhibit 1002, p. 11
`
`

`

`
`
`UNITED STATES DEPARTMENTOF COMMERCE
`United States Patent and Trademark Office
`Address: COMMISSIONER FOR PATENTS.
`P.O, Box 1450
`Alexandria, Virginia 22313-1450
`WWLISpto,gov
`
` APPLICATION NO,
`
`ATTORNEY DOCKETNO,
`
`CONFIRMATION NO.
`
`M0546.70012US01
`
`7597
`
`15/988.463
`
`ISSUE DATE
`
`10/23/2018
`
`PATENT NO.
`
`10106603
`
`23628
`
`7590
`
`10/03/2018
`
`WOLF GREENFIELD & SACKS, P.C.
`600 ATLANTIC AVENUE
`BOSTON, MA 02210-2206
`UNITED STATES OF AMERICA
`
`The projected patent numberandissue date are specified above.
`
`ISSUE NOTIFICATION
`
`Determination of Patent Term Adjustment under 35 U.S.C. 154 (b)
`(application filed on or after May 29, 2000)
`
`The Patent Term Adjustmentis 0 day(s). Any patent to issue from the above-identified application will include
`an indication of the adjustmenton the front page.
`
`If a Continued Prosecution Application (CPA) wasfiled in the above-identified application, the filing date that
`determines Patent Term Adjustmentis the filing date of the most recent CPA.
`
`Applicant will be able to obtain more detailed information by accessing the Patent Application Information
`Retrieval (PAIR) WEBsite (http://pair.uspto. gov).
`
`Any questions regarding the Patent Term Extension or Adjustment determination should be directed to the
`Office of Patent Legal Administration at (571)-272-7702. Questions relating to issue and publication fee
`payments should be directed to the Application Assistance Unit (AAU) of the Office of Data Management
`(ODM) at (571)-272-4200.
`
`APPLICANTT(s)(Please see PAIR WEBsite http://pair.uspto.gov for additional applicants):
`
`Stuart Alexander Cook, Singapore, SINGAPORE;
`Singapore Health Services PTE LTD., Singapore, SINGAPORE;
`National University of Singapore, Singapore, SINGAPORE;
`Sebastian Schaefer, Singapore, SINGAPORE;
`
`The United States represents the largest, most dynamic marketplace in the world andis an unparalleled location
`for business investment, innovation, and commercialization of new technologies. The USA offers tremendous
`resources and advantages for those who invest and manufacture goods here. Through SelectUSA,our nation
`works to encourage andfacilitate business investment. To learn more about why the USAis the best country in
`
`the world to develop technology, manufacture products, and grow your business, visit SelectUSA. gov.
`Lassen - Exhibit 1002, p. 12
`Lassen - Exhibit 1002, p. 12
`
`IR103 (Rev. 10/09)
`
`

`

`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`UNITED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address: COMMISSIONER FOR PATENTS
`P.O. Box 1450
`Alexandria, Virginian 22313-1450
`www.usplo.gov
`
`APPLICATION NO.
`
`FILING DATE
`
`FIRST NAMED INVENTOR
`
`ATTORNEY DOCKETNO.
`
`CONFIRMATION NO,
`
`15/988,463
`
`05/24/2018
`
`Stuart Alexander Cook
`
`M0546.70012US01
`
`7597
`
`WOLF GREENFIELD & SACKS,P.C.COnner
`600 ATLANTIC AVENUE
`MERTZ, PREMA MARIA
`BOSTON, MA 02210-2206
`UNITED STATES OF AMERICA
`
`1646
`
`09/25/2018
`
`ELECTRONIC
`
`Please find below and/or attached an Office communication concerning this application or proceeding.
`
`Thetime periodforreply,if any, is set in the attached communication.
`
`Notice of the Office communication was sent electronically on above-indicated "Notification Date" to the
`following e-mail address(es):
`Patents_eOfficeAction@WolfGreenfield.com
`WGS_eOfficeAction@WolfGreenfield.com
`
`PTOL-90A (Rev. 04/07)
`
`Lassen - Exhibit 1002, p. 13
`Lassen - Exhibit 1002, p. 13
`
`

`

`1. &] The amendmentfiled on 20 September 2018 under 37 CFR 1.312 has been considered, and has been:
`
`a) entered.
`
`b) (1) entered as directed to matters of form not affecting the scopeof the invention.
`
`c)( disapproved because the amendmentwasfiled after the paymentof the issuefee.
`Any amendmentfiled after the date the issue fee is paid must be accompaniedbya petition under 37 CFR 1.313(c)(1) and
`the required fee to withdraw the application from issue.
`
`disapproved. See explanation below.
`
`entered in part. See explanation below.
`
`Responseto Rule 312 Communication
`
`15/988 ,463
`
`Art Unit
`
`Application No.
`
`Applicant(s)
`
`-- The MAILING DATEofthis communication appears on the cover sheet with the correspondence address —
`
`CHilliard U.S. Patent and Trademark Office
`
`PTOL-271 (Rev. 04-01)
`
`Reponse to Rule 312 Communication
`
`Part of Paper No.
`
`Lassen - Exhibit 1002, p. 14
`Lassen - Exhibit 1002, p. 14
`
`

`

`
`
`UNITED Stares ParENT AND TRADEMARK OFFIGE
`
`UNTTED STATES DEPARTMENT OF COMMERCE
`United States Patent and Trademark Office
`Address:COMMISSIONER FOR PATENTS
`PO. Box 1450
`Alexandria, Virginia 22313-1450
`WWW. uspto gov
`
`
`
`
`15/988 463
`05/24/2018
`Stuart Alexander Cook
`M0546.70012US01
`CONFIRMATIONNO. 7597
`
` APPLICATIONNUMBER | FILING OR 371(C) DATE | FIRST NAMED APPLICANT | ATTY. DOCKETNO./TITLE
`
`
`
`
`
`23628
`WOLF GREENFIELD & SACKS, P.C.
`
`600 ATLANTIC AVENUE
`
`BOSTON, MA 02210-2206
`
`PUBLICATION NOTICE
`
`LN0440100
`
`Title: TREATMENT OF FIBROSIS
`
`Publication No.US-2018-0265579-A1
`Publication Date:09/20/2018
`
`NOTICE OF PUBLICATION OF APPLICATION
`
`The above-identified application will be electronically published as a patent application publication pursuant to 37
`CFR 1.211, et seq. The patent application publication number and publication date are set forth above.
`
`The publication may be accessed through the USPTO's publically available Searchable Databases via the
`Internet at www.uspto.gov. Thedirectlink to access the publication is currently http://www.uspto.gov/pattt/.
`
`The publication process established by the Office does not provide for mailing a copy of the publication to
`applicant. A copy of the publication may be obtained from the Office upon payment of the appropriate fee set
`forth in 37 CFR 1.19(a)(1). Orders for copies of patent application publications are handled by the USPTO's
`Public Records Division. The Public Records Division can be reached by telephoneat (571) 272-3150 or (800)
`972-6382, by facsimile at (571) 273-3250, by mail addressed to the United States Patent and Trademark Office,
`Public Records Division, Alexandria, VA 22313-1450 or via the Internet.
`
`In addition, information on the status of the application, including the mailing date of Office actions and
`the dates of receipt of correspondencefiled in the Office, may also be accessedvia the Internet through
`the Patent Electronic Business Center at www.uspto.gov using the public side of the Patent Application
`Information and Retrieval (PAIR) system. Thedirectlink to accessthis status information is currently
`https://portal.uspto.gov/pair/PublicPair. Prior to publication, such status information is confidential and may only
`be obtained by applicantusing the private side of PAIR.
`
`Further assistancein electronically accessing the publication, or about PAIR, is available by calling the Patent
`Electronic Business Center at 1-866-217-9197.
`
`
`
`Office of Data Managment, Application Assistance Unit (571) 272-4000, or (571) 272-4200, or 1-888-786-0101
`
`page 1 of 1
`
`Lassen - Exhibit 1002, p. 15
`Lassen - Exhibit 1002, p. 15
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Docket No.: M0546.70012US01
`(PATENT)
`
`First Named Inventor:
`Application No.:
`Confirmation No.:
`Filed:
`For:
`Examiner:
`
`Stuart Alexander Cook
`15/988,463
`7597
`May 24, 2018
`TREATMENTOF FIBROSIS
`P. M. Mertz
`
`Art Unit:
`
`1646
`
`Dated: September 20, 2018 Electronic Signature for Nancy J. Arsenault:
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`[hereby certify that this paper (along with any paper referred to as being attached or enclosed) is being transmitted via the Office's electronic filing
`system in accordance with 37 C.F.R. § 1.6{a)(4).
`
`/Nancy J. Arsenault’
`
`§ 1.312
`AMENDMENT AFTER ALLOWANCE UNDER37 C.F.R.
`
`
`Mail Stop Issue Fee
`Commissioner for Patents
`P.O. Box 1450
`Alexandria. VA 22313-1450
`
`DearSir:
`
`INTRODUCTORY COMMENTS
`
`In responseto the Notice to File Corrected Application Papers dated September 19, 2017,
`
`please amend the above-identified U.S. patent application as follows:
`
`Amendments to the Specification begin on page 2 of this paper.
`
`Remarks/Arguments begin on page 3 ofthis paper.
`
`6627428.1
`
`Lassen - Exhibit 1002, p. 16
`Lassen - Exhibit 1002, p. 16
`
`

`

`Application No.: 15/988,463
`Amendmentdated September 20, 2018
`After Allowance Under 37 C.F.R. § 1.312
`
`2
`
`Docket No,: M0546.70012US01
`
`AMENDMENTSTO THE SPECIFICATION
`
`Please amend the Specification as follows:
`
`Please replace the paragraph starting on page 92, line 6 with the following replacement
`
`paragraph:
`
`Wefirst generated RNA-seq data (Figure 16Errer!}Reference-seurecenetfound,) and determined
`
`the genotype of 69 ethnically matched (Chinese) individuals in the cohort using a SNP array based
`
`on fluorescent probe hybridization supplied by Illumina (HumanOmniExpress 24).
`
`6627428.1
`
`Lassen - Exhibit 1002, p. 17
`Lassen - Exhibit 1002, p. 17
`
`

`

`Application No.: 15/988,463
`Amendmentdated September 20, 2018
`After Allowance Under 37 C.F.R. § 1.312
`
`3
`
`Docket No,: M0546.70012US01
`
`REMARKS
`
`This paperis responsive to the Notice to File Corrected Application Papers dated
`
`September 19, 2017 (“Notice”).
`
`In the Notice, the Office indicated that page 92, line 6 of the
`
`specification submitted on May 24, 2018 contained the phrase “Error! Reference source not found.”
`
`By this amendment, Applicant has amended the specification to remove the phrase “Error!
`
`Reference source not found.” on page 92, line 6. No new matter has been added.
`
`Applicant believes no fee is due with this response. However,if a fee is due, please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012US01 from whichthe undersigned is
`
`authorized to draw.
`
`Dated: September 20, 2018
`
`Respectfully submitted,
`
`By /Amy McMahon Krom/
`Amy McMahon Krom
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS, P.C.
`600 Atlantic Avenue
`Boston, Massachusetts 02210-2206
`617.646.8000
`
`6627428.1
`
`Lassen - Exhibit 1002, p. 18
`Lassen - Exhibit 1002, p. 18
`
`

`

`
` L UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Commissionerfor Patents
`United States Patent and Trademark Office
`P.O. Box 1450
`Alexandria, VA 22313-1450
`www.uspto.gov
`
`Application No. : 15988463
`Applicant
`: Cook
`Filing Date : 05/24/2018
`Date Mailed : 09/19/2018
`
`NOTICE TO FILE CORRECTED APPLICATION PAPERS
`
`Notice ofAllowance Mailed
`
`This application has been accorded an Allowance Date and is being prepared for issuance. The
`application, however, is incomplete for the reasons below.
`
`Applicantis given two (2) months from the mail date of this Notice within which to respond. This
`time period for reply is extendable under 37 CFR 1.136(a) for only TWO additional MONTHS.
`
`The informalities requiring correction are indicated in the attachment(s). If the informality pertains to the
`abstract, specification (including claims) or drawings,
`the informality must be corrected with an
`amendment in compliance with 37 CFR 1.121 (or, if the application is a reissue application, 37 CFR
`1.173). Such an amendment maybe filed after payment of the issue fee if limited to correction of
`informalities noted herein. See Waiver of 37 CFR 1.312 for Documents Required bythe Office of Patent
`Publication, 1280 Off. Gaz. Patent Office 918 (March 23, 2004).
`In addition, if the informality is not
`corrected until after payment of the issue fee, for purposes of 35 U.S.C. 154(b)(1)(iv), “all outstanding
`requirements” will be considered to have been satisfied when the informality has been corrected. A
`failure to respond within the above-identified time period will
`result
`in the application being
`ABANDONED.
`
`See attachment(s).
`
`A copyofthis notice MUSTbe returned with the reply. Please address response to
`“Mail Stop Issue Fee, Commissionerfor Patents,
`P.O. Box 1450, Alexandria, VA 22313-1450”.
`
`/Quang Nguyen/
`Publication Branch
`Office of Data Management
`(571) 272-4200
`
`Lassen - Exhibit 1002, p. 19
`Lassen - Exhibit 1002, p. 19
`
`

`

`Application No. 15988463
`
`IDENTIFICATION OF APPLICATION DEFICIENCIES
`IN APPLICATION FILED ON OR AFTER SEPTEMBER 16, 2012
`
`Applicant must provide legible text for the following item(s).
`
`
`Specification filed 12/16/2016, page(s) 92, line 6 ("Error! Reference source not found.".
`
`[| Claims filed , claim(s) .
`
`[| Other:.
`
`Applicant must provide missing information on the following page(s) of the specification by amending the
`specification to add the missing text. No new matter may be added.
`Page/line no(s).
`
`The specification refers to one or more applications by attorney docket numberand does not show the U.S.
`application number(s). Applicant must supply the U.S. application numberin place ofeach attorney docket
`number.
`Page/line no(s).
`
`Applicant must provide an Abstract of the Disclosure.
`
`The Application Data Sheet (ADSdated ) does not supply the inventor’s city and/or does not supply the
`inventor’s U.S. state and/or does not supply the inventor's country. Applicant must submit a signed,in
`accordance with 37 CFR 1.76(e) and 1.33(b), application data sheetthat corrects this deficiency. To be in
`compliance with 37 CFR 1.76, the corrected application data sheet must identify the information being
`changed by using underlining for additions and strikethroughs orbrackets for deletions.
`
`
`
`
`
`
`
`Other:
`
`Lassen - Exhibit 1002, p. 20
`Lassen - Exhibit 1002, p. 20
`
`

`

`IN THE UNITED STATES PATENT AND TRADEMARKOFFICE
`
`Docket No.: M0546.70012US01
`(PATENT)
`
`First Named Inventor:
`Application No.:
`Confirmation No.:
`Filed:
`For:
`Examiner:
`Art Unit:
`
`Stuart Alexander Cook
`15/988,463
`7597
`May 24, 2018
`TREATMENTOFFIBROSIS
`P. M. Mertz
`1646
`
`/Nancy J. Arsenault/
`
`Certificate of Electronic Filing under 37 C.F.R. § 1.8
`| hereby certify that this paper (along with any paper referred to as being attached or enclosed)is being transmitted via the Office's electronic filing
`system in accordance with 37 C.F.R. § 1.6(a)(4).
`
`Dated: September 20, 2018
`
`Electronic Signature for Nancy J, Arsenault:
`
`RESPONSE TO NOTICE TO CORRECTED APPLICATION PAPERS
`
`Mail Stop Issue Fee
`Commissioner for Patents
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`Dear Sir:
`
`In response to the Notice to File Corrected Application Papers mailed September 19, 2018,
`
`Applicant respectfully submits an Amendment After Allowance Under 37 C.F.R. §1.312 and a
`
`Copy of the Notice.
`
`Applicant believes no fee is due with this response. However,if a fee is due, please charge
`
`Deposit Account No. 23/2825 under Docket No. M0546.70012US01 from which the undersignedis
`
`authorized to draw.
`
`Dated: September 20, 2018
`
`Respectfully submitted,
`
`6627489.1
`
`By /Amy McMahon Krom/
`Amy McMahon Krom
`Registration No.: 73,073
`WOLF, GREENFIELD & SACKS, P.C.
`600 Atlantic Avenue
`Boston, Massachusetts 02210-2206
`617.646.8000
`
`Lassen - Exhibit 1002, p. 21
`Lassen - Exhibit 1002, p. 21
`
`

`

`Electronic AcknowledgementReceipt
`
`Application Number:
`
`15988463
`
`Confirmation Number:
`
`Title of Invention:
`
`TREATMENT OF FIBROSIS
`
`First Named Inventor/Applicant Name:
`
`Stuart Alexander Cook
`
`International Application Number:
`
`
`
`
`
`Filer: Amy Jeanette McMahon/NancyArsenault
`
`Filer Authorized By:
`
`AmyJeanette McMahon
`
`Attorney Docket Number:
`
`M0546.70012US01
`
`Receipt Date:
`
`20-SEP-2018
`
`
`
`Filing Date: 24-MAY-2018
`
`Time Stamp:
`
`11:55:21
`
`Application Type:
`
`Utility under 35 USC 11 1{a)
`
`Paymentinformation:
`
` Warnings:
`
`Document
`
`eae
`
`5
`
`File Size(Bytes)/
`Message Digest
`
`Multi
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`Pages
`(if appl.)
`
`Miscellaneous Incoming Letter
`
`M054670012US01-TRN-AM.pdf
`
`b3Foalb26ff6i794-98bS0a202356
`
`Lassen - Exhibit 1002, p. 22
`Lassen - Exhibit 1002, p. 22
`
`

`

`Information:
`
`
`
`M054670012US01-312AMN-
`
`951 leaMb0c3702deccMibeicl330daéc1 al
`
`Information:
`
`Amendment after Notice of Allowance (Rule 312)
`
`
`Specification
`
`
`Applicant Arguments/Remarks Made in an Amendment
`
`Warnings:
`Information:
`
`Miscellaneous Incoming Letter
`
`M054670012US01-NTCAP-AM.
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`
`Ma24sSef2ch7sf5alS3 bebSbc 1 daasdd | aac
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`
`M05467001 2US01-RNTCAP-
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`
`This Acknowledgement Receipt evidences receipt on the noted date by the USPTOof the indicated documents,
`characterized by the applicant, and including page counts, where applicable.It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`New Applications Under 35 U.S.C. 111
`If a new application is being filed and the application includes the necessary componentsfora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shownonthis
`AcknowledgementReceiptwill establish thefiling date of the application.
`National Stage of an International Application under 35 U.S.C. 371
`If a timely submission to enter