C U R R I C U L U M V I T A E
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`B.A. Amherst College (magna cum laude)
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`M.D. Harvard Medical School
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`Medical Intern, Montefiore Hospital and
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`Medical Center, Bronx, NY
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`Assistant Medical Resident,
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`Harvard Medical Service, Boston City Hospital
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`Research Fellow in Pharmacology, Harvard Medical School;
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`Fellow in Medicine (Clinical Pharmacology),
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`Massachusetts General Hospital
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`DAVID J. GREENBLATT, M.D.
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`Current Title:
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`Louis Lasagna Endowed Professor, Department of Immunology (formerly the Department
`of Pharmacology and Experimental Therapeutics); Professor of Psychiatry, Medicine,
`and Anesthesia, Tufts University School of Medicine; Special and Scientific Staff
`(Research), Tufts Medical Center, Boston MA
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`Education and Training:
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`1966
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`1970
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`1970-1971
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`1971-1972
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`1972-1974
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`Professional Appointments:
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` Harvard Medical School and Massachutte General Hospital
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`1974-1979
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`1976-1979
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` Tufts University School of Medicine (TUSM) and Tufts Medical Center (TMC):
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`Professor of Psychiatry, Tufts University School of
`1979-present
`Medicine, Boston MA (TUSM)
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`Associate Medical Staff, Tufts Medical Center (TMC)
`1979-2015
`Special and Scientific Staff (Research), TMC
`2015-
`Associate Professor of Medicine, TUSM
`1979-1984
`1983-1996, 2001-2002 Chair, Institutional Review Board, TMC/TUSM
`1984-present
`Professor of Medicine, TUSM
`1988-1991
`Professor of Pharmacology, TUSM
`1991-present
`Professor of Pharmacology and Experimental Therapeutics
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`(with tenure), TUSM
`1994-2010
`Chairman, Department of Pharmacology and Experimental
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`Therapeutics, TUSM
`1995-present
`Professor of Anesthesia, TUSM
`1995-2002
`Program Director, General Clinical Research Center, TMC
`1997-present
`Louis Lasagna Endowed Professor of Pharmacology and
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`Experimental Therapeutics, TUSM
`2002-2010
`Associate Program Director, Clinical/Translational
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`Research Center, TMC/TUSM
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`Awards and Honors:
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`Assistant Professor of Medicine, Harvard Medical School;
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`Assistant in Medicine, Massachusetts General Hospital
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`Chief, Clinical Pharmacology Unit,
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`Massachusetts General Hospital
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`Rawls-Palmer Progress in Medicine Award and Lecture,
`American Society for Clinical Pharmacology and Therapeutics
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`Clinical Pharmacology Unit Developmental Grant,
`Pharmaceutical Manufacturers' Association Foundation,
`Washington, D.C.
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`Wellcome Visiting Professor in the Basic Medical Sciences
`(the Burroughs Wellcome Fund and Federation of American Societies
`for Experimental Biology),
`East Carolina University School of Medicine, Greenville, N.C.
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`Paul Ehrlich Visiting Professor of Clinical Pharmacology,
`University of Miami School of Medicine
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`Sterling Visiting Professor,
`Boston University School of Medicine
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`The McKeen Cattell Award,
`(with Drs. 0. Bellmann, H.R. Ochs, and M. Knüchel)
`American College of Clinical Pharmacology
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`T. George Bidder Distinguished Lectureship in Psychopharmacology,
`University of California at Los Angeles
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`Pfizer Visiting Professor of Clinical Pharmacology,
`Morehouse University School of Medicine, Atlanta, GA
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`Research Fellow of the Medical Foundation, Inc., Boston
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`Pfizer Lecturer in Clinical Pharmacology
`(at various institutions)
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`1972-74
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`1978-87
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`1980
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`1980
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`1981
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`1983
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`1984
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`1985
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`1988
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`1997
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`2001
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`2002
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`2005
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`2013 Outstanding Speaker Award,
` American Association for Clinical Chemistry
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`2015 Distinguished Faculty Award,
` Tufts University School of Medicine
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`2016 Award in Excellence in Clinical Pharmacology,
` Pharmaceutical Research and Manufacturers of America Foundation
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`2016 Man of Good Conscience Award,
` Association of Women Psychiatrists
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`Certification
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`1991
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`Editorial Boards
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`Journal of Clinical Psychopharmacology (Co-Editor-in-Chief)
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`Clinical Pharmacology in Drug Development (Editor-in-Chief)
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`Journal of Clinical Pharmacology
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`British Journal of Clinical Pharmacology (2011-2016)
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`Biopharmaceutics and Drug Disposition
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`Distinguished Service Award,
`American College of Clinical Pharmacology
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`Distinguished Investigator Award,
`American College of Clinical Pharmacology
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`Research Achievement Award in Clinical Sciences,
`American Association of Pharmaceutical Scientists
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`American Board of Clinical Pharmacology, Inc.
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`Xenobiotica
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`Neuropsychopharmacology (1986-1990)
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`Drug Investigation
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`Drugs and Aging
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`Pharmacology and Toxicology
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`Drugs and Therapy Perspectives
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`Professional Societies
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`American Society for Clinical Investigation (Emeritus)
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`American Society for Pharmacology and Experimental Therapeutics
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`American Federation for Clinical Research
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`American Society for Clinical Pharmacology and Therapeutics
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`Board of Directors, 1983-85
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`American College of Clinical Pharmacology
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`Board of Regents, 1981-85, 1987-91;
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`Honarary Regent, 1994-;
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`President-Elect, 1994-1996;
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`President, 1996-1998
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`American College of Neuropsychopharmacology (Fellow) (1974-2011)
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`International Society for the Study of Xenobiotics
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`British Pharmacological Society
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`ORIGINAL RESEARCH ARTICLES
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`1. Tursky B, Greenblatt DJ: Local vascular and thermal changes that
`accompany electric shock. Psychophysiology 3:371-380, 1967.
`2. Greenblatt DJ, DiMascio A, Messier M, Stotsky B: Magnesium pemoline and
`job performance in mentally handicapped workers. Clinical
`Pharmacology and Therapeutics 10:530-533, 1969.
`3. Greenblatt DJ, Tursky B: Local vascular and impedence changes induced
`by electric shock. American Journal of Physiology 216:712-718, 1969.
`4. Tursky B, Greenblatt DJ, O'Connell DN: Electrocutaneous threshold
`changes produced by electric shock. Psychophysiology 7:490-498, 1970.
`5. Greenblatt DJ, Shader RI: Psychopharmacologic management of anxiety in
`the cardiac patient. Psychiatry in Medicine 2:490-498, 1970.
`6. Greenblatt DJ, Shader RI: Meprobamate: a study of irrational drug use.
`American Journal of Psychiatry 127:1297-1303, 1971.
`7. Greenblatt DJ, Shader RI: The clinical choice of sedative-hypnotics.
`Annals of Internal Medicine 77:91-100, 1972.
`8. Greenblatt DJ, Shader RI: On the psychopharmacology of beta adrenergic
`blockade. Current Therapeutic Research 14:615-625, 1972.
`9. Greenblatt DJ, Koch-Weser J: Adverse reactions to spironolactone: a
`report from the Boston Collaborative Drug Surveillance Program.
`Journal of the American Medical Association 225:40-43, 1973.
`10. Greenblatt DJ, Shader RI: Anticholinergics. New England Journal of
`Medicine 288:1215-1219, 1973.
`11. Greenblatt DJ, Koch-Weser J: Adverse reactions to propranolol in
`hospitalized medical patients: a report from the Boston Collaborative
`Drug Surveillance Program. American Heart Journal 86:478-484, 1973.
`12. Greenblatt DJ, Koch-Weser J: Adverse reactions to intravenous diazepam:
`a report from the Boston Collaborative Drug Surveillance Program.
`American Journal of Medical Sciences 266:261-266, 1973.
`13. Greenblatt DJ, Duhme DW, Koch-Weser J, Smith TW: Evaluation of digoxin
`bioavailability in single-dose studies. New England Journal of
`Medicine 289:651-654, 1973.
`14. Greenblatt DJ, Koch-Weser J: Adverse reactions to beta-adrenergic
`receptor blocking drugs: a report from the Boston Collaborative Drug
`Surveillance Program. Drugs 7:118-129, 1974.
`15. Greenblatt DJ, Shader RI: Drug abuse and the emergency room physician.
`American Journal of Psychiatry 131:559-562, 1974.
`16. Duhme DW, Greenblatt DJ, Koch-Weser J: Reduction of digoxin toxicity
`associated with measurement of serum levels: a report from the Boston
`Collaborative Drug Surveillance Program. Annals of Internal Medicine
`80:516-519, 1974.
`17. Koch-Weser J, Duhme DW, Greenblatt DJ: Influence of serum digoxin
`concentration measurements on frequency of digitoxicity. Clinical
`Pharmacology and Therapeutics 16:284-287, 1974.
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`18. Greenblatt DJ, Duhme DW, Koch-Weser J, Smith TW: Intravenous digoxin as
`a bioavailability standard: slow infusion and rapid injection.
`Clinical Pharmacology and Therapeutics 15:510-513, 1974.
`19. Greenblatt DJ, Koch-Weser J: Oral contraceptives and hypertension: a
`report from the Boston Collaborative Drug Surveillance Program.
`Obstetrics and Gynecology 44:412-417, 1974.
`20. Greenblatt DJ, Duhme DW, Koch-Weser J, Smith TW: Equivalent
`bioavailability from digoxin elixir and rapid-dissolution tablets.
`Journal of the American Medical Association 229:1774-1776, 1974.
`21. Greenblatt DJ, Shader RI, Koch-Weser J. Pharmacokinetic determinants
`of the response to single doses of chlordiazepoxide. American Journal
`of Psychiatry 131:1395-1397, 1974.
`22. Greenblatt DJ, Koch-Weser J: Clinical toxicity of chlordiazepoxide and
`diazepam in relation to serum albumin concentration: a report from the
`Boston Collaborative Drug Surveillance Program. European Journal of
`Clinical Pharmacology 7:259-262, 1974.
`23. Greenblatt DJ, Duhme DW, Koch-Weser J, Smith TW: Bioavailability of
`digoxin tablets and elixir in the fasting and postprandial states.
`Clinical Pharmacology and Therapeutics 16:444-448, 1974.
`24. Greenblatt DJ, Shader RI, Koch-Weser J, Franke K: Slow absorption of
`intramuscular chlordiazepoxide. New England Journal of Medicine
`291:1116-1118, 1974.
`25. Greenblatt DJ, Duhme DW, Koch-Weser J, Smith TW: Comparison of one- and
`six-day urinary digoxin excretion in single-dose bioavailability
`studies. Clinical Pharmacology and Therapeutics 16:813-816, 1974.
`26. Greenblatt DJ, Shader RI: Benzodiazepines. New England Journal of
`Medicine 291:1011-1015, 1239-1241, 1974.
`27. Greenblatt DJ, Shader RI, Koch-Weser J: Flurazepam hydrochloride.
`Clinical Pharmacology and Therapeutics 17:1-14, 1975.
`28. Sokol GH, Greenblatt DJ, Littman P, Franke K, Koch-Weser J:
`Chlordiazepoxide metabolism in mice following hepatic irradiation.
`Pharmacology 13:248-251, 1975.
`29. Greenblatt DJ, Shader RI, Koch-Weser J: Psychotropic drug use in the
`Boston area: a report from the Boston Collaborative Drug Surveillance
`program. Archives of General Psychiatry 32:518-521, 1975.
`30. Shader RI, Greenblatt DJ, Salzman C, Kochansky GE, Harmatz JS:
`Benzodiazepines: safety and toxicity. Diseases of the Nervous System
`36(No.5,Sect.2):23-26, (May) 1975.
`31. Greenblatt DJ, Shader RI, Koch-Weser J: Pharmacokinetics in clinical
`medicine: oxazepam versus other benzodiazepines. Diseases of the
`Nervous System 36(No.5, Sect.2):6-13, (May) 1975.
`32. Greenblatt DJ, Shader RI, Koch-Weser J: Flurazepam hydrochloride, a
`benzodiazepine hypnotic. Annals of Internal Medicine 83:237-241,
`1975.
`33. Koup JR, Greenblatt DJ, Jusko WJ, Smith TW, Koch-Weser J:
`Pharmacokinetics of digoxin in normal subjects after intravenous bolus
`and infusion doses. Journal of Pharmacokinetics and Biopharmaceutics
`3:181-192, 1975.
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`34. Greenblatt DJ, Koch-Weser J: Clinical pharmacokinetics. New England
`Journal of Medicine 293:702-705, 964-970, 1975.
`35. Greenblatt DJ, Allen MD, Koch-Weser J: Accidental poisoning with
`psychotropic drugs in children. American Journal of Diseases in
`Children 130:507-511, 1976.
`36. Greenblatt DJ, Shader RI, Koch-Weser J. Serum creatine phosphokinase
`concentrations after intramuscular chlordiazepoxide and its solvent.
`Journal of Clinical Pharmacology 16:118-121, 1976.
`37. Greenblatt DJ, Bolognini V, Koch-Weser J, Harmatz JS: Pharmacokinetic
`approach to the clinical use of lidocaine intravenously. Journal of
`the American Medical Association 236:273-277, 1976.
`38. Pfeifer HJ, Greenblatt DJ, Koch-Weser J: Clinical use and toxicity of
`intravenous lidocaine: a report from the Boston Collaborative Drug
`Surveillance Program. American Heart Journal 92:168-173, 1976.
`39. Greenblatt DJ, Duhme DW, Koch-Weser J, Smith TW: Assessment of
`methodology in single-dose studies of digoxin bioavailability.
`Pharmacology 14:182-190, 1976.
`40. Greenblatt DJ, Shader RI, Lofgren S: Rational psychopharmacology for
`patients with medical diseases. Annual Review of Medicine 27:407-420,
`1976.
`41. Greenblatt DJ, Shader RI, Harmatz JS, Franke K, Koch-Weser J: Influence
`of magnesium and aluminum hydroxide mixture on chlordiazepoxide
`absorption. Clinical Pharmacology and Therapeutics 19:234-239, 1976.
`42. Greenblatt DJ, Smith TW, Koch-Weser J: Bioavailability of drugs: the
`digoxin dilemma. Clinical Pharmacokinetics 1:36-51, 1976.
`43. Greenblatt DJ, Ransil BJ, Harmatz JS, Smith TW, Duhme DW, Koch-Weser J:
`Variability of 24-hour urinary creatinine excretion by normal
`subjects. Journal of Clinical Pharmacology 16:321-328, 1976.
`44. Stanski DR, Greenblatt DJ, Lappas DG, Koch-Weser J, Lowenstein E:
`Kinetics of high dose intravenous morphine in cardiac surgery
`patients. Clinical Pharmacology and Therapeutics 19:752-756, 1976.
`45. Pfeifer HJ, Greenblatt DJ, Koch-Weser J: Clinical toxicity of reserpine
`in hospitalized patients: a report from the Boston Collaborative Drug
`Surveillance Program. American Journal of Medical Sciences 271:269-
`276, 1976.
`46. DiMascio A, Bernardo DL, Greenblatt DJ, Marder JE: A controlled trial
`of amantadine in drug-induced extrapyramidal disorders. Archives of
`General Psychiatry 33:599.602, 1976.
`47. Greenblatt DJ, Schillings RT, Kyriakopoulos AA, Shader RI, Sisenwine
`SF, Knowles JA, Ruelius HW: Clinical pharmacokinetics of lorazepam.
`I. Absorption and disposition of oral 14C-lorazepam. Clinical
`Pharmacology and Therapeutics 20:329-341, 1976.
`48. Stanski DR, Greenblatt DJ, Selwyn A, Shader RI, Franke K, Koch-Weser J:
`Plasma and cerebrospinal fluid concentrations of chlordiazepoxide and
`its metabolites in surgical patients. Clinical Pharmacology and
`Therapeutics 20:571-578, 1976.
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`49. Greenblatt DJ, Koch-Weser J: Intramuscular injection of drugs. New
`England Journal of Medicine 295:542-546, 1976.
`50. Greenblatt DJ, Duhme DW, Allen MD, Koch-Weser J: Clinical toxicity of
`furosemide in hospitalized patients: a report from the Boston
`Collaborative Drug Surveillance Program. American Heart Journal 94:6-
`13, 1977.
`51. Allen MD, Greenblatt DJ: Accidental salicylate poisoning.
`Paediatrician 6:244-249, 1977.
`52. Greenblatt DJ, Shader RI, Harmatz JS, Franke K, Koch-Weser J:
`Absorption rate, blood concentrations, and early response to oral
`chlordiazepoxide. American Journal of Psychiatry 134:559-562, 1977.
`53. Greenblatt DJ, Joyce TH, Comer WH, Knowles JA, Shader RI, Kyriakopoulos
`AA, MacLaughlin DS, Ruelius HW: Clinical pharmacokinetics of
`lorazepam. II. Intramuscular injection. Clinical Pharmacology and
`Therapeutics 21:222-230, 1977.
`54. Ransil BJ, Greenblatt DJ, Koch-Weser J: Evidence for systematic
`temporal variation in 24-hour urinary creatinine excretion. Journal
`of Clinical Pharmacology 17:108-119, 1977.
`55. Greenblatt DJ, Comer WH, Elliott HW, Shader RI, Knowles JA, Ruelius HW:
`Clinical pharmacokinetics of lorazepam. III. Intravenous injection
`(preliminary report). Journal of Clinical Pharmacology 17:490-494,
`1977.
`56. Greenblatt DJ, Knowles JA, Comer WN, Shader RI, Harmatz JS, Ruelius HW:
`Clinical pharmacokinetics of lorazepam. IV. Long-term oral
`administation. Journal of Clinical Pharmacology 17:495-500, 1977.
`57. Ameer B, Greenblatt DJ: Acetaminophen. Annals of Internal Medicine
`87:202-209, 1977.
`58. Greenblatt DJ, Pfeifer HJ, Ochs HR, Franke K, MacLaughlin DS, Smith TW,
`Koch-Weser J: Pharmacokinetics of quinidine in humans after
`intravenous, intramuscular and oral administration. Journal of
`Pharmacology and Experimental Therapeutics 202:365-378, 1977.
`59. Greenblatt DJ, Allen MD, Shader RI: Toxicity of high-dose flurazepam in
`the elderly. Clinical Pharmacology and Therapeutics 21:355-361, 1977.
`60. Greenblatt DJ, DiMascio A, Harmatz JS, Bernardo DL, Marder JR:
`Pharmacokinetics and clinical effects of amantadine in drug-induced
`extrapyramidal symptoms. Journal of Clinical Pharmacology 17:704-708,
`1977.
`61. Greenblatt DJ, Allen MD, Noel BJ, Shader RI: Acute overdosage with
`benzodiazepine derivatives. Clinical Pharmacology and Therapeutics
`21:497-514, 1977.
`62. Shader RI, Greenblatt DJ: Clinical implications of benzodiazepine
`pharmacokinetics. American Journal of Psychiatry 134:652-656, 1977.
`63. Pfeifer HJ, Greenblatt DJ, Koch-Weser J: Adverse reactions to practolol
`in hospitalized patients: a report from the Boston Collaborative Drug
`Surveillance Program. European Journal of Clinical Pharmacology
`12:167-170, 1977.
`64. Allen MD, Greenblatt DJ, Noel BJ: Meprobamate overdosage: a continuing
`problem. Clinical Toxicology 11:501-516, 1977.
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`65. Greenblatt DJ, Harmatz JS, Stanski DR, Shader RI, Franke K, Koch-Weser
`J: Factors influencing blood concentrations of chlordiazepoxide: a use
`of multiple regression analysis. Psychopharmacology 54:277-282, 1977.
`66. Greenblatt DJ, Shader RI, Franke K, MacLaughlin DS, Ransil BJ, Koch-
`Weser J : Kinetics of intravenous chlordiazepoxide: sex differences in
`drug distribution. Clinical Pharmacology and Therapeutics 22:893-903,
`1977.
`67. Shader RI, Greenblatt DJ, Harmatz JS, Franke K, Koch-Weser J:
`Absorption and disposition of chlordiazepoxide in young and elderly
`male volunteers. Journal of Clinical Pharmacology 17:709-718, 1977.
`68. Greenblatt DJ, Harmatz JS, Shader RI: Sex differences in diazepam
`protein binding in patients with renal insufficiency. Pharmacology
`16:26-29, 1978.
`69. Ochs HR, Greenblatt DJ, Bodem G, Smith TW: Sprinolactone. American
`Heart Journal 96:389-400, 1978.
`70. Pfeifer HJ, Greenblatt DJ: Clinical toxicity of theophylline in
`relation to cigarette smoking: a report from the Boston Collaborative
`Drug Surveillance Program. Chest 73:455-459, 1978.
`71. Greenblatt DJ: Determination of desmethyldiazepam in plasma by
`electron-capture GLC: application to pharmacokinetic studies of
`clorazepate. Journal of Pharmaceutical Science 67:427-429, 1978.
`72. Gayes JM, Greenblatt DJ, Lloyd BL, Harmatz JS, Smith TW: Cerebrospinal
`fluid digoxin concentrations in humans. Journal of Clinical
`Pharmacology 18:177-179, 1978.
`73. Greenblatt DJ, Harmatz JS, Shader RI: Factors influencing diazepam
`pharmacokinetics. International Journal of Clinical Pharmacology and
`Biopharmacy 16:177-179, 1978.
`74. Ochs HR, Bodem G, Bales G, Greenblatt DJ, Smith TW: Increased Clearance
`of digoxin in rabbits during repeated administration. Journal of
`Pharmacology and Experimental Therapeutics 205:516-524, 1978.
`75. Ochs HR, Greenblatt DJ, Woo E, Franke K, Pfeifer JH, Smith TW: Single-
`and multiple-dose pharmacokinetics of oral quinidine sulfate and
`gluconate. American Journal of Cardiology 41:770-777, 1978.
`76. Greenblatt DJ, Shader RI, Weinberger DR, Allen MD, MacLaughlin DS:
`Effect of a cocktail on diazepam absorption. Psychopharmacology
`57:199-203, 1978.
`77. Greenblatt DJ, Franke K, Huffman DH: Impairment of antipyrine clearance
`in humans by propranolol. Circulation 57:1161-1164, 1978.
`78. Greenblatt DJ, Allen MD: Intramuscular injection-site complications.
`Journal of the American Medical Association 240:542-544, 1978.
`79. Greenblatt DJ, Shader RI, Franke K, Harmatz JS: Pharmacokinetics of
`chlordiazepoxide and metabolites following single and multiple oral
`doses. International Journal of Clinical Pharmacology and Biopharmacy
`16:486-493, 1978.
`80. Lloyd BL, Greenblatt DJ, Allen MD, Harmatz JS, Smith TW:
`Pharmacokinetics and bioavailability of digoxin capsules, solution,
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`and tablets after single and multiple doses. American Journal of
`Cardiology 42:129-146, 1978.
`81. Greenblatt DJ, Allen MD: Toxicity of nitrazepam in the elderly: a
`report from the Boston Collaborative Drug Surveillance Program.
`British Journal of Clinical Pharmacology 5:407-413, 1978.
`82. Ochs HR, Greenblatt DJ, Woo E, Franke K, Smith TW: Effect of
`propranolol on pharmacokinetics and acute electrocardiographic changes
`following intravenous quinidine in humans. Pharmacology 17:301-306,
`1978.
`83. Greenblatt DJ, Shader RI, MacLeod SM, Sellers EM, Franke K, Giles HG:
`Absorption of oral and intramuscular chlordiazepoxide. European
`Journal of Clinical Pharmacology 13:267-274, 1978.
`84. Ochs HR, Greenblatt DJ, Dengler JH: Absorption of oral tetracycline in
`patients with Billroth-II gastrectomy. Journal of Pharmacokinetics
`and Biopharmaceutics 6:295-303, 1978.
`85. Ochs HR, Greenblatt DJ, Bodem G, Harmatz JS: Dose-independent
`pharmacokinetics of digoxin in humans. American Heart Journal 97:507-
`511, 1978.
`86. Greenblatt DJ, Woo E, Allen MD, Orsulak PJ, Shader RI: Rapid recovery
`from massive diazepam overdose. Journal of the American Medical
`Association 240:1872-1874, 1978.
`87. Greenblatt DJ, Shader RI, MacLeod SM, Sellers EM: Clinical
`pharmacokinetics of chlordiazepoxide. Clinical Pharmacokinetics
`3:381-394, 1978.
`88. Sokol GH, Greenblatt DJ, Lloyd BL, Georgotas A, Allen MD, Harmatz JS,
`Smith TW, Shader RI: Effect of abdominal radiation therapy on drug
`absorption in humans. Journal of Clinical Pharmacology 18:388-396,
`1978.
`89. Ochs HR, Greenblatt DJ, Woo E, Smith TW: Reduced quinidine clearance in
`elderly persons. American Journal of Cardiology 42:481-485, 1978.
`90. Greenblatt DJ, Franke K, Shader RI: Analysis of lorazepam and its
`glucuronide metabolite by electron-capture gas-liquid chromatography:
`use in pharmacokinetic studies of lorazepam. Journal of Chromatog-
`raphy 146: 311-320, 1978.
`91. Shader RI, Georgotas A, Greenblatt DJ, Harmatz JS, Allen MD: Impaired
`absorption of desmethyldiazepam from clorazepate by magnesium aluminum
`hydroxide. Clinical Pharmacology and Therapeutics 24:308-315, 1978.
`92. Woo E, Greenblatt DJ, Ochs HR: Short- and long-acting quinidine
`preparations: clinical implications of pharmacokinetic differences.
`Angiology 29:243-250, 1978.
`93. MacLeod SM, Sellers EM, Giles HG, Billings BJ, Martin PR, Greenblatt
`DJ, Marshman JA. Interaction of disulfiram with benzodiazepines.
`Clinical Pharmacology and Therapeutics 24:583-589, 1978.
`94. Sellers EM, Greenblatt DJ, Zilm DH, Degani N: Decline in
`chlordiazepoxide plasma levels during fixed-dose therapy of alcohol
`withdrawal. British Journal of Clinical Pharmacology 6:370-372, 1978.
`95. Greenblatt DJ, Shader RI: Pharmacokinetic understanding of antianxiety
`drug therapy. Southern Medical Journal 7l(Suppl 2): 2-9, 1978.
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`96. Greenblatt DJ, Shader RI: Dependence, tolerance, and addiction to
`benzodiazepines: clinical and pharmacokinetic considerations. Drug
`Metabolism Reviews 8:13-28, 1978.
`97. Greenblatt DJ: Simultaneous gas chromatographic analysis for diazepam
`and its major metabolite, desmethyldiazepam, with use of double
`internal standardization. Clinical Chemistry 24:1838-1841, 1978.
`98. Greenblatt DJ, Allen MD, MacLaughlin DS, Harmatz JS, Shader RI:
`Diazepam absorption: effect of antacids and food. Clinical
`Pharmacology and Therapeutics 24:600-609, 1978.
`99. MacLeod SM, Sellers EM, Giles HG, Billings BJ, Martin PR, Greenblatt
`DJ, Marshman JA: The interaction of disulfiram with benzodiazepines.
`Clinical Pharmacology and Therapeutics 24:583-589, 1978.
`100. Stanski DR, Greenblatt DJ, Lowenstein E: Kinetics of intravenous and
`intramuscular morphine. Clinical Pharmacology and Therapeutics 24:52-
`59, 1978.
`101. Greenblatt DJ, Shader RI: Prazepam and lorazepam, two new
`benzodiazepines. New England Journal of Medicine 299:1342-1344, 1978.
`102. Mudge GH, Lloyd BL, Greenblatt DJ, Smith TW: Inotropic and toxic
`effects of a polar cardiac glycoside derivative in the dog.
`Circulation Research 43:847-854, 1978.
`103. Greenblatt DJ, Allen MD, Harmatz JS, Noel BJ, Shader RI: Correlates of
`outcome following acute glutethimide overdosage. Journal of Forensic
`Sciences 24:76-86, 1979.
`104. Greenblatt DJ, Shader RI, Franke K, MacLaughlin DS, Harmatz JS, Allen
`MD, Werner A, Woo E: Pharmacokinetics and bioavailability of
`intravenous, intramuscular and oral lorazepam in humans. Journal of
`Pharmaceutical Sciences 68:57-63, 1979.
`105. Greenblatt DJ: Reduced serum alhumin concentration in the elderly: a
`report from the Boston Collaborative Drug Surveillance Program.
`Journal of the American Geriatrics Society 27:20-22, 1979.
`106. Miller RR, Porter J, Greenblatt DJ: Clinical importance of the
`interaction of phenytoin and isoniazid: a report from the Boston Drug
`Surveillance Program. Chest 75:356-358, 1979.
`107. Greenblatt DJ: Predicting steady-state serum concentrations of drugs.
`Annual Review of Pharmacology and Toxicology 19:347-356, 1979.
`108. Woo E, Greenblatt DJ: Pharmacokinetic and clinical implications of
`quinidine protein binding. Journal of Pharmaceutical Sciences 68:466-
`470, 1979.
`109. Woo E, Greenblatt DJ: Massive benzodiazepine requirements during acute
`alcohol withdrawal: a clinical and pharmacokinetic study. American
`Journal of Psychiatry 136:821-823, 1979.
`110. Greenblatt DJ, Allen MD, MacLaughlin DS, Huffman DH, Harmatz JS,
`Shader RI: Single- and multiple-dose kinetics of oral lorazepam in
`humans: the predictability of accumulation. Journal of
`Pharmacokinetics and Biopharmaceutics 7:159-179, 1979.
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`111. Lowenthal IS, Parker LM, Greenblatt DJ, Brown BL, Samy TSA:
`Pharmacokinetic analysis of neocarzinostatin in normal and tumor-
`bearing rodents. Cancer Research 39:1547-1551, 1979.
`112. Greenblatt DJ, Allen MD, Locniskar A, Harmatz JS, Shader RI: Lorazepam
`kinetics in the elderly. Clinical Pharmacology and Therapeutics
`26:103-113, 1979.
`113. Pfeifer HJ, Greenblatt DJ, Friedman P: Effect of three antibiotics on
`theophylline kinetics. Clinical Pharmacology and Therapeutics 26:36-
`40, 1979.
`114. Sellers EM, Greenblatt DJ, Giles HG, Naranjo CA, Kaplan H, MacLeod SM:
`Chlordiazepoxide and oxazepam disposition in cirrhosis. Clinical
`Pharmacology and Therapeutics 26:240-246, 1979.
`115. Allen MD, Greenblatt DJ, Harmatz JS, Shader RI: Single-dose kinetics
`of prazepam, a precursor of desmethyldiazepam. Journal of Clinical
`Pharmacology 19:445-450, 1979.
`116. Greenblatt DJ, Locniskar A: Spectrophotometric assay of antipyrine in
`plasma: a reevaluation. International Journal of Clinical
`Pharmacology and Biopharmacy 17:401-404, 1979.
`117. Ochs HR, Grube E, Greenblatt DJ, Woo E, Bodem G: Intravenous
`quinidine: pharmacokinetic properties and effects on left ventricular
`performance in humans. American Heart Journal 99:468-475, 1980.
`118. Greenblatt DJ, Allen MD, Harmatz JS, Noel BJ, Shader RI: Overdosage
`with pentobarbital and secobarbital: assessment of factors related to
`outcome. Journal of Clinical Pharmacology 19:758-768, 1979.
`119. Allen MD, Greenblatt DJ, Noel BJ: Self-poisoning with over-the-counter
`hypnotics. Clinical Toxicology 15:151-158, 1979.
`120. Ochs HR, Greenblatt DJ, Allen MD, Harmatz JS, Shader RI, Bodem G:
`Effect of age and Billroth gastrectomy on absorption of desmethyl-
`diazepam from clorazepate. Clinical Pharmacology and Therapeutics
`26:449-456, 1979.
`121. Greenblatt DJ, Allen MD, Harmatz JS, Shader RI: Diazepam disposition
`determinants. Clinical Pharmacology and Therapeutics 27:301-312,
`1980.
`122. Ochs HR, Greenblatt DJ, Harmatz JS, Bodem G: Serum digoxin
`concentrations and subjective manifestations of toxicity.
`Pharmacology 20:149-154, 1980.
`123. Greenblatt DJ, Shader RI, Harmatz JS, Georgotas A: Self-rated sedation
`and plasma concentrations of desmethyldiazepam following single doses
`of clorazepate. Psychopharmacology 66:289-290, 1979.
`124. Ochs HR, Greenblatt DJ, Lloyd BL, Woo E, Sonntag M, Smith TW: Entry of
`quinidine into cerebrospinal fluid. American Heart Journal 100:341-
`346, 1980.
`125. Allen MD, Greenblatt DJ, Arnold JD: Single and multiple dose kinetics
`of estazolam, a triazolo benzodiazepine. Psychopharmacology 66:267-
`274, 1979.
`126. Winokur A, Rickels K, Greenblatt DJ, Snyder PJ, Schatz NJ: Withdrawal
`reaction from chronic, low-dose diazepam administration: a double-
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`blind placebo-controlled case study. Archives of General Psychiatry
`37:101-105, 1980.
`127. Allen MD, Greenblatt DJ, Noel BJ: Overdosage with antipsychotic
`agents. American Journal of Psychiatry 137:234-236, 1980.
`128. Woo E, Greenblatt DJ: Effect of food on enteral absorption of
`quinidine. Clinical Pharmacology and Therapeutics 27:188-193, 1980.
`129. Miller R, Greenblatt DJ: Clinical effects of chloral hydrate in
`hospitalized medical patients. Journal of Clinical Pharmacology
`19:669-674, 1979.
`130. Allen MD, Greenblatt DJ: Comparative protein binding of diazepam and
`desmethyldiazepam. Journal of Clinical Pharmacology 21:219-223, 1981.
`131. Allen MD, Greenblatt Dl, Harmatz JS, Shader RI: Desmethyldiazepam
`kinetics in the elderly after oral prazepam. Clinical Pharmacology
`and Therapeutics 28:196-202, 1980.
`132. Allen MD, Greenblatt DJ, Harmatz JS, Smith TW: Effect of magnesium-
`aluminum hydroxide and kaolin-pectin on absorption of digoxin from
`tablets and capsules. Journal of Clinical Pharmacology 21:26-30,
`1981.
`133. Ochs HR, Greenblatt DJ, Woo E: Clinical pharmacokinetics of quinidine.
`Clinical Pharmacokinetics 5:150-168, 1980.
`134. Greenblatt DJ: Electron-capture GLC determination of clobazam and
`desmethylclobazam in plasma. Journal of Pharmaceutical Sciences
`69:1351-1352, 1980.
`135. Krogstad DJ, Moellering RC, Greenblatt DJ: Single-dose kinetics of
`intravenous vancomycin. Journal of Clinical Pharmacology 20:197-201,
`1980.
`136. Allen MD, Greenblatt DJ, LcCasse Y, Shader RI: Pharmacokinetic study
`of lorazepam overdosage. American Journal of Psychiatry 137:1414-
`1415, 1980.
`137. Ochs HR, Busse J, Greenblatt DJ, Allen MD: Entry of lorazepam into
`cerebrospinal fluid. British Journal of Clinical Pharmacology 10:405-
`406, 1980.
`138. Greenblatt DJ, Laughren TP, Allen MD, Harmatz JS, Shader RI: Plasma
`diazepam and desmethyldiazepam concentrations during long-term
`diazepam therapy. British Journal of Clinical Pharmacology 11:35-40,
`1981.
`139. Greenblatt DJ, Ochs HR, Lloyd BL: Entry of diazepam and its major
`metabolite into cerebrospinal fluid. Psychopharmacology 70:89-93,
`1980.
`140. Ochs HR, Carstens G, Greenblatt DJ: Reduction in lidocaine clearance
`during continuous infusion and by coadministration of propranolol.
`New England Journal of Medicine 303:373-377, 1980.
`141. Greenblatt DJ, Divoll M, Harmatz JS, Shader RI: Oxazepam kinetics:
`effects of age and sex. Journal of Pharmacology and Experimental
`Therapeutics 215:86-91, 1980.
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`142. Sellers EM, Giles HG, Greenblatt DJ, Naranjo CA: Differential effects
`on benzodiazepine disposition by disulfiram and ethanol. Arzneimittel
`Forschung 30:882-886, 1980.
`143. Greenblatt DJ, Shader RI: Effects of age and other drugs on
`benzodiazepine kinetics. Arzneimittel Forschung 30:886-890, 1980.
`144. Divoll M, Greenblatt DJ: Alcohol does not enhance diazepam absorption.
`Pharmacology 22:263-268, 1981.
`145. Divoll M, Greenblatt DJ: Plasma concentrations of temazepam, a 3-
`hydroxy benzodiazepine, determined by electron-capture gas-liquid
`chromatography. Journal of Chromatography 222:125-128, 1981.
`146. Ochs HR, Pabst J, Greenblatt DJ, Dengler HJ: Noninteraction of
`digitoxin and quinidine. New England Journal of Medicine 303:672-674,
`1980.
`147. Ochs HR, Bodem G, Greenblatt DJ: Impairment of digoxin clearance by
`coadministration of quinidine. Journal of Clinical Pharmacology
`21:396-400, 1981.
`148. Ochs HR, Bodem G, Greenblatt DJ: Effect of dose on bioavailability of
`oral digoxin. European Journal of Clinical Pharmacology 19:53-55,
`1981.
`149. Moellering RC, Krogstad DJ, Greenblatt DJ: Vancomycin therapy in
`patients with impaired renal function: a nomograpm for dosage. Annals
`of Internal Medicine 94:343-346, 1981.
`150. Ochs HR, Greenblatt DJ, Bodem G: Single- and multiple-dose kinetics of
`intravenous digoxin. Clinical Pharmacology and Therapeutics 28:340-
`345, 1980.
`151. Abernethy DR, Greenblatt DJ: Impairment