- DORLAND’S
`
`ILLUSTRATED
`
`MEDICALglgg
`
`DICTIONARY
`
`SAUNDERS
`
`afEbwier
`
`
`
`Genome Ex. 1020
`Page 1 of 7
`
`

`

`SAUNDERS
`ELSEVIER
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`DORLAND’S ILLUSTRATED MEDICAL DICTIONARY
`31
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`st edltlon
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`Copyright © 2007, 2003, 2000, 1994, 1988, 1985, 1981, 1974, I965, 1957, 1951, 1947.
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`Doriand’s illustrated medical dictionary.
`Philadephia: Saunders
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`v.: ill.; 27 cm.
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`Irregular.
`Began publication with 23rd ed.
`Description based on: 26th ed.
`Continues: American illustrated medical dictionary.
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`1. Medicine—Dictionaries. I. Dorland, WA. Newman (William Alexander Newman), 1864—1956.
`HDNIM: l. Dictionaries, Medical. 2. Reference Books, Medical]
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`Genome Ex. 1020
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`Page 2 of 7 L
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`Genome Ex. 1020
`Page 2 of 7
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`

`#—
`
`Canalitll oou..l.|o|ollll.l'lIIIIIolloloo.uIoo-I..-OO-ICOIOII..IIIIt.I...DIIIIIC
`
`andesartan CHE-Ken]
`
`
`
`
`Canalis Continued
`
`
`
`vertebral canal: the canal formed by the fare.
`c. vertebra'lls [TA]
`is divided into two compartments, smla tympani and scala vestibuli. b)“
`mina in the successive vertebrae, which encloses the spinal cord and
`the lamina spiralis.
`meninges; called also flitdliiiar)’ mini, neural canal, and spam! Erma].
`
`spiral mnal of modiolus: a canal following
`c. spira‘lls modl‘oll [TA]
`c. vomerorostra'lls [TA]
`vomerorostral canal: a canal
`[Geared
`the course of the bony spiral lamina of the cochlea and containing the
`between the vomer and sphenoidal roan-uni.
`s iral ganglion of the cochlear division of the vestibulocochlear nerve.
`an inconsum
`canal:
`e. vomerovaglna'lia [TA]
`vomerovagmal
`alled also Rarmtbui marl.
`
`the ala of the
`opening formed by the articulating margins of
`c. ulna'rls {TA}
`ulnar canal: a small superficial canal at the base of the
`vomer
`and
`the
`body of
`the
`sphenord
`bone;
`called
`also
`
`h rpnthenar bounded by the flexor retinaculum and the flexor carpi
`basipbmyogmi Mimi,
`literati superior turrrmbarikrr renal, and ”mining
`naris muscle, which transmits blood vessels and the ulnar nerve
`
`(anal.
`from the forearm to the hand. Called also Cigar: renal and [age d: Guys».
`
`hereditary nonpolyposis colorcctal c.
`(llNI’CC)
`a group of
`hereditary,
`autosomal dominant
`cancers
`characterized by dime“,
`adenontas of the colon and rectum without polmosrs. Two types hm
`been distinguished: in type I, all affected persons
`ave Colorectal cancers-
`in type 2, some family members have cancer in other parts of the bod):
`such as the female genital tract, stomach, brain, breast, or urinary tract:
`Both
`types
`are
`caused
`by; mutations
`in mlsmatcb repair
`genes,
`particularly MSHZ and ML 1, and are characterized by nucrosatellite
`Instability. Called also Lynrb syndrome. Type 2 rs also called mater-family
`nmdmm.
`.
`.
`.
`latent c.
`cancer discovered, to the absence of any clinical manifest-.3.
`tions, in the course of histological examination; cf. mi: r.
`mclanotie c. malignant melanoma.
`mule spinners’ c. one of the first types of slon cancer known to be
`caused by occupational exposure, affecting workers in the cotton spinning
`industry because of exposure to arsenic, tar, and carcinogenic 0113mm;
`form of squamous cell carcinoma.
`nonmclanotna skin c’s name given to a group of common skin cancers
`that do no: metastasiae, including basal cell carcrnoma and squamous DE"
`carcinoma.
`ve rise to climcally evident distant
`a small cancer am may
`occult c.
`metastases before it is itself clinically etectable; cf. latent a
`soot c.
`chimney-sweeps‘ c.
`swamp c.
`l..pythiosis.
`2. a general term for any of several syndromes
`in horses consrsttng of skin or mucosal lesions with ulcers and granuloma-
`tous tissue; they may be on the head, trunk, or legs. Included are torturous
`bahunmfarir, mtmopbrbmyean}, and ”biotic
`inflammatory irritation of
`tar c.
`squamous cell carcinoma caused by
`fumes of tar or by the imitating effect of tar on the skin.
`canacer-ernla (ltan"sar—e'me-a)
`the presence of cancer cells in the
`bloo .
`can-cer-ioci-dal
`(kan”sar—i—si’dal) [cancers L. made-re to kill]
`onooh‘tic-
`can-cer-l-gen-ic (kan"sar—i—jen'ik)
`giving rise to a malignant tumul“:
`cf. carcinogenic and ramgmr‘r. Called also rammgenir.
`can-cere-cicdal
`(kan"sar-o—si’dal) oncolydc.
`can-cer-oogen-Ic Gmn"sar—o-jen'ilt) mneerigenic.
`can-cemcpho-bla (kan”ser—o-fo‘be-e)
`cancerphobia.
`cancceroous
`(kan’sar~35) of the nature of or pertaining to cancer.
`cancceropho-bla (Iran"sar-fo'be-a) [tamer + phobia]
`irrational fear 0f
`cancer.
`
`a free-floatin particle within the
`can-a-lith (kan’a-lith“) {canal + Jirb]
`endolymph of the semicircular canal; the presence 0 canalidrs can cause
`benign paroxysmal positional vertigo.
`1. formation of canals, natural or
`cama-ll-za-tion (lmn"a-li-2.a’shan}
`pathologic.
`2.
`surgical
`establishment
`of
`canals
`for
`drainage.
`3. recanalizauon.
`4.
`in psychology, formation in the central nervous
`system of new pathways by repeated passage of nerve impulses.
`ca-nan-plas-ty (Lun’a-lo-plas"te)
`canalplasty.
`ca-naloplas-ty (ka’nal'plas-te) plastic reconstruction ofa passage, as of
`the external auditory meatus.
`a type of fowlpox seen in canaries.
`ca-na-ry-pox (ka-na’re—polts)
`Gama-ea (kan'a-sa)
`trademark for a preparation of mesulamine.
`Can -a waif-fa
`(lean"a-val'ya)
`the jack bean, a genus of W’est Indian
`[aura of the family Leguminosae, widely used as food for humans and
`ivestock. C. enofir’mir DC. and other species are the source of canavanine
`and concanavalin.
`Can-awan disease (Iran's-ton) [ll-'Iyrtelle May Comma, American neu—
`rologist, 1879—1933]
`spongy degeneration of the central nervous system;
`see under drgenn'mbn.
`Gan-a-van-van Bevgaert-Ber-trand disease (ltan'a-van valm bo’gert
`bar-tral'm") {M.M. Caravan; Ludo can Bugatti, Belgian neurologist, 1897-
`1939; Ivan Georges Bdrm-mi, French neurologist, 1893-1965]
`spongy
`degeneration of the central nervous system; see under degeneration.
`can-awaonlne (Ira-nav'a-nEn)
`an analogue of arginine found in alfalfa
`seeds and the jack bean; used in experimental medicine to study enzymes
`that usually act on arginine.
`can-cel-Iat-ed (kan'sa-lac'ad)
`cellous.
`
`having a
`
`i
`
`'
`
`Camel-clan (kan—si’das)
`acetate.
`
`trademark for a preparation of caspflllmgin
`
`cancroid.
`can-cri-forrn (kang’kr'f-form)
`can-croid (lmng’ltroid) [L. cancer, gen. mum, crab, malignant tumfl”
`mid]
`resembling cancer.
`canker.
`can-crum (kang'ltram) [1...]
`c. na’si gangrenous rhinitis of children.
`_
`c. o’ris noma (def. l).
`the base SI unitpflunf“;
`can-dela led]
`(km-rulers) [1... models candle]
`, in a given directhlIzl. ”
`nous intensity, equal to the luminous intensi
`source that emits a monochromatic radiation 0 frequency 540 X 10 him
`mdlafla
`and that has a radiant intensity in that direction of 1/683 watt per ste
`Called also candle.
`trademark for preparations of umdiddin'
`Gan-dep-tin (kan-dep’lin)
`oanade-sar-tan
`ci-Iex-e-til
`(kan"da-sahr’tan)
`an
`an Kittensin
`receptor anmgonisc used as an antihypertensive; administere orallY-
`
`II
`
`'
`
`
`
`
`
`
`
`
`
`Genome BX. 102! '
`Page 3 of 7
`
`lattice-like suucorre;
`
`can—
`
`any structure
`
`[1... “a lattice”]
`
`(kart—sofas) of a reticular, spongy, or lattice-like struc—
`can-oelolous
`nrre; said mainly of bony tissue.
`can-eeI-Ius
`(ltan—sal'as) pl. mnwi’li
`arranged like a lattice.
`a neoplastic disease
`canocer
`(kan’sar) [1,. “crab," “malignant turnor"]
`the natural course ofwhich is fatal. Cancer cells, unlike benign tumor cells,
`exhibit the properties of invasion and metastasis and are highly anaplascic.
`Cancer includes the two broad categories of carcinoma and sarcoma, but in
`normal usage it is often used synonymously with carcinoma.
`aniline c.
`cancer usually of the urinary bladder, occurring among those
`who work with aniline dyes; called also dye wot-iron" r.
`betel c.
`a type of squamous cell carcinoma of the cheek mucous
`membranes, seen in India and other Asian countries where betel nut,
`oftendgiixed with tobacco,
`is held in the buocal vestibule for prolonged
`peno .
`chimney sweeps’ c.
`a
`e of squamous cell carcinoma of the skin of
`the scrotum that was formery common in chimney sweeps owing to skin
`irritation by soot. Called also mot r.
`colloid c. mudnous carcinoma.
`contact c.
`cancer developing in a part of the body in contact with a
`previously existing cancer.
`cystic c.
`see under rumor.
`dendritic c. papillary carcinoma.
`dancer attacking simultaneously or
`c. a deux [Fr. “cancer in two”]
`consecutively two persons who live together.
`dye workers' 1:.
`aniline c.
`encephaloid c.
`former name for medulla)» ram‘nama.
`endothelial c.
`endothelioma.
`epithelial c.
`carcinoma.
`glandular c.
`adenocarcinoma.
`
`284
`
`Genome Ex. 1020
`Page 3 of 7
`
`

`

`
`
`
`Carcinoma
`
`“in-r c.. aclnlc cell c.. aclnoua c.
`a slow-
`'
`'
`mot characterized hyacinic cells arranged in smglllolg‘nfidhnfizhéfiua:
`tutti. usuallv omit-ring In the pancreas or saliva
`glands panicularl
`in
`WaCallodalmmmirnflorm
`‘,
`“daft,”
`t?” 01' m I?” W.
`Wattle e.
`adenoid cystic c.
`“mold cyfllc l'.'._.
`carcinoma characterized by bands or cylinders of
`'
`‘
`or mucunous stronta se mun or sun'uunde
`limit; of small epithelial cells. It all: ars Es one or moredol’ytill-1:132:
`m3: cribrifom. solid. and tubular.
`e usual site is the salivary lands.
`but hismlngtcalh' sumlar tumors ap
`‘ elsewhere. Mali
`ant an inva-
`sire but slow-grown , It spreads Biz-infiltrating the b oodsu‘eam and
`Wingurfll spaces.
`ed also admocym'r a. mlnflbrm r., and 95m.
`N015: Certain unrelated tumors may have a cylindromatous or adenoid
`'c Farm-n, e.g.. ameloblastoma.
`Mid aquamaua cell c.
`adenoacanthoma.
`mutate“ ‘c.
`l. adenoacanthoma.
`2. a diverse category of
`broncho
`'c carcinoma .wuh areas of glandular,
`squamOus, and
`l
`differenuauon; In some cases inclusion of a tumor in this
`category rather than In one of the more specific categories of bronchu-
`'c carcinoma has been questioned.
`“Ml c'a atlfiagge girloupkiplf carcinomas arisinginfi'om, or forming
`matures rcsem
`g.
`e
`a
`or a
`can .
`'
`m! glands or sebaceous glamh. Ppendngw (
`l particularly
`ant adrenal nor-
`c. at adrenal cortex. adrenecortlcal c.
`a mali
`fiul nunor that can cause endocrine disorders so
`as Cushing syn-
`drum: or adrenogenital syndrome.
`rare
`a
`Wee-producing c.. eldoshrane-eacreung c.
`malignant form of aldosterouoma; it is larger than an aldosterone—pro—
`ducing adenotna.
`bronchjoloalveolar e.
`alveolar c., alveolar cell c.
`We. a type olameloblasm-a in which malignant epithe—
`lial transformation has omitted; the metastatic lesions do not resemble
`the primary unnor histologically, instead usually resembling squamous
`
`_
`arising
`mc.ofwmnd,enaplasficthyroide. atypeof
`‘
`'
`'
`atypialmllsol‘vafioustypcsandpaeterns;
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`tic lesion
`basal cell c., cystic a rare subtype occurring as a cys
`formed by central degeneration, characterized histologically by edema-
`tons strotna nmmed
`neoplastic cells.
`basal cell c., flbmeplthellal
`premalignant fibroepithelioma.
`basal cell c.. Infiltration. basal cell c.. inflltratiue
`a type in
`which strands of basal cells infiltrate between collagen bundles of the
`subcutaneous tissue.
`a form of nodular basal cell carcinoma
`bull cell c.. mlerenedular
`in which the nodules are particularly small and usually do not ulcerate.
`baaal cell c., morpbeaferrn. basal cell c., morphealllte, baaal
`cell c.. morphalc
`a
`usually seen on the face or neclr as white,
`scarlike. telangiectatic lesions with poorl defined borders, character-
`ized histologically by strands of basal ce ls surrounded by dense hya-
`Ellind stroma, and usually spreading laterally. Called also alarming bum!
`re r.
`baaal cell c... multlcentrlc. baaal cell c.. multlfeceI. basal cell
`c.. multilocal auperflclal
`superficial basal cell c.
`basal cell c.. nodular
`the most con-anon type of basal cell carci-
`noma, usually seen on the face as one or several small. waxy. translucent
`nodules with rolled ed
`around a central depression; these may be
`ulcerated. crusted. or fieding and may spread laterally or invade
`deeply. Two subtypes are micronodular and noduloulcerative basal
`cell carcutoma.
`basal cell c.. neduleulceratlve nodular basal cell carcinoma that
`has undergone ulceration.
`whose lesions contain brown or
`basal cell c... pigmented 3
`black igment; it grows slowly an is seen more often in darker-skinned
`indivi uals. Some cases are associated with chronic arsenic poisoning.
`basal cell c., acleroalng morpheaform basal cell c.
`baaal cell c., superficial
`a type
`seen on the trunk as a
`plaque or pla tits that are superficial, slowly spreadindg; mematous.
`mm} or
`and scaly, and
`re threadlilte, raised borders. Called
`new basal cell c
`' c term referring to any of numerous car-
`basaleld c.
`l. a no
`cinomas that resemble basal cell carcinoma.
`2. a rare transitional cell
`mtcinoma of the anus, resembling basal cell carcinoma of the skin.
`Callcdalsodamgmeamir.
`a type of carcinoma of
`hasoequarnous c., baaoequantoue cell c.
`the skin that has elements of both basal cell and squamous cell types.
`bile duct e.
`l. cholangiocarcinoma.
`2. cholangiocellular c.
`bllharzlal c.
`schismsomal bladder c.
`a
`bronchlealveelar c., brenchiolar c.. bronchioloalveolar c.
`to
`variant
`of adenocardnoma of the lung, with oobimnar
`cuboidal epithelial cells lining the alveolar septa and projecting
`into alveolar spaces in branching papillary formations. Called also aim-
`Icrc. arm-lama, alveolar-eye. or tamer, Whittier: madma-
`carrimma, bruntbaak‘rahr c. or momma, and hambiaalomlar
`Wm.
`bronchoalueolar c., bronchoalvenlar cell c. bronchioloalveolar c.
`bronchogenlc c.
`any of a large grou of carcinomas of the lung, so
`called because they arise from the epith 'um of the bronchial tree. Four
`pfimarysubtypcaaredistinguishedmdmmrfiamaftbrhmg, may
`m small cell carcinoma, andW cell carcinoma.
`cholanglecellular c.
`a rare type of bepamoellular carcinoma arising
`born the cholan 'olea composed of tumor cells
`'
`the epithe-
`lialoellsofthe cfolangiolesamngedinoorckoonnstingoftwolayersof
`
`
`
` c
`
`B c
`
`ard-Doma- 94), Noduloulcenli“: (3). lamented; (0. supetficfll-
`
`
`
`
`295
`
`Genome Ex. 1020
`
`Page 4 of 7
`
`Genome Ex. 1020
`Page 4 of 7
`
`

`

`
`Carcinoma Continued
`
`
`
`
`
`_
`representing
`
`a type in which the cells are cylin-
`
`cells surrounding a minute lumen. Called also Mir dun c. tl‘fmbtpdflt‘ bile
`dad a. and chin '
`‘
`.
`char-Ionic c.
`oriocarcinorna.
`choroid plexus c.
`an aggressive anaplastic _ tumor
`malignant transformation of a choroid plexus paptlloma.
`.
`clur coll c.
`1. see under admomrtinm.
`2. renal cellt.
`clinging c. of breast
`in rare form of dates] carcinoma In 51111.1.
`cloacoocnlc anal c.
`basaloid c. (def. 2)-
`collold c. mutinous c.
`cont-do c.
`comedocarcinoma.
`corpus c., c. 0! corpus marl uterine corpus c.
`cm.pnducln¢ o.
`a type of carcinoma of the adrenal cortex that
`secretes mm‘sol, causing Cashing syndrome.
`cfibri'l‘om c.
`l. adenoid cystic c.
`2. an adenoid cystic carcinoma
`of the lactiferous ducts, one of the subtvpes of ductal carcinoma in
`situ; many tumors have combined crihrifotm and micropapillary
`patterns.
`cylindrical c., cylindrical cell c.
`drical (columnar) cells.
`duct c.. duchl c.
`carcinoma of a duct, such as of the pancreas or
`breast see also dam! r. in am.
`duct-l c. of the prostate see under admomrrinoma.
`duct-l c. In situ (DCIS)
`any ofa large group of in situ carcinomas of
`the lactiferous ducts; subtvpm distinguished by histology include corne-
`docarcinoma, cribril'ornt carcinoma, and micropapilla ’ carcinoma, but
`:13“? tumors include areas of more than one type. Cal ed also introduc-
`I".
`eccrinc c.
`any of the admiral carcinomas that originate in the eccrine
`sweat glands; see also (minds-ammonia.
`cmbmnll c.
`a highly malignant germ cell tumor that is a primitive
`form of cardnoma, probably of primitive embryonal cell derivation; it
`maghefoundeitherinpureformoraspartofamixed
`celltumor
`an has a histological appearance similar to that of a yo
`sac tumoc In
`females, there is a median age of 15; in males the majority of patients are
`adolescents or older.
`1:. on coir-m carcinoma of the skin manifest as thickening and
`induration over large areas of the chest, frequently as a result of metas-
`tasis from a primary breast lesion.
`endomtrlal c.
`carcinoma of the endometrium of the corpus uteri,
`one of the most common gynecological cancers, mainly affecting post-
`meno usal women; a common symptom is abnormal vaginal bleeding.
`It
`ingauadcs typts ranging in malignancy from locally invasive to
`metastasizing.
`carcinoma characterized by glandular patterns that
`ondoanctriokl c.
`resemble those ofthe cndometrium, acorn-ring in the uterine fundus and
`in the ovarian; see also underMW.
`e. of undulations
`cudornetrial c
`cpldormoid c.
`squamous cell c. (def. 2).
`epithelial c.
`a malignant epidtelioma, such as of the respiratory tract
`or ovary.
`c. ex pleomorphic adenoma.
`c. c: Intacd hauler
`We 1:.
`a malignant epithelial neoplasm with marked outward
`growth lilac a wart or papilloma.
`leomorphic ade-
`c. ctr plcomcrpltic adenom a type of malignant
`nomadntusuailyoccursinthemlivaryglands ofol eradults;artepi-
`dielial malignancy arises in a
`' ting mixed tumor, with metastasis
`only.r of the mall
`t epith '
`component. The term is sometimes
`used synonymougavllidi malignant mired mar.
`mm tall. duct c.
`cholangioocllular c.
`I'Ihrnllllulllr c.
`a rare variant of hepatooellular carcinoma in which
`there is a solitary mass, no evidence of cirrhosis, and no male predom-
`inance. It is characterized hismlogically by eosinophilic
`hepa-
`that contain swollen mitochondria,
`plasmic
`‘es, and
`' e bodies and have
`rominent nucleoli;
`e cells are surrounded
`byastmmaofthin
`elcollagenbands.Calledalsofibmlame
`hm
`“adore.“drmidghndJolllctdaruwmldc.
`a
`ofthy—
`roid gland carcinoma with many follicles, although it traffic areas
`without follicles; it is more common in women and is more malignant
`than papillary carcinoma of thyroid giand.
`
`a poorly differentiated, highly malignant, epithelial neg.
`giant cell c.
`plasm containing numerous very large, nrulunuclcated tumor cells, gud‘
`as occurs in die lungs.
`giant cell c. of thyroid gland a type of arts lastic carcinoma of th
`thyroid
`land, containing numerous giant ce ls, some of which 3,:
`multinuc eated.
`giant cell c.
`c. gigantocollula re
`glandular c.
`adenocarcinoma.
`granulosa cell c.
`a gtanulosa cell tumor that has undergone malig.
`nanr transformation.
`primary carcinoma of the liver cells; SYmFtUms
`hepatocollulnr c.
`include hcpatomegaly, abdominal pain. weight loss.
`jaundice, hem“.
`peritoneum, and other symptoms of the presence of an abdominal
`mass. It is rare in North America and Western Europe but is one of
`the most common malignancies
`in parts of sub~Saharan Africa
`Southeast Asia, East Asia, and elsewhere. A strong association seem;
`to exist with chronic hepatitis B virus infection, and definite but lea
`strong associations with some types of cirrhosrs and hepatitis C virus
`infection. Called also btpatoma, mligmnr bepatoma, and bcpammrmm'
`Hiirthlc cell c.
`a ma ig-nant Hilrthlc cell tumor.
`hypernophroid c.
`renal cell c.
`Infantile cmbryonal c.
`yolk sac tumor.
`lnl'lllrnllng Iobular c.
`invasive lobular c.
`Inflammatory c. of breast
`a highly malignant carcinoma 0f the
`hrcast. presentin with pink to red skin discoloration,
`tenderness,
`edema, and rapi
`enlargement of the breast; it usually invades derrml
`lymphatic vessels.
`c. in cl‘tu
`a neoplastic entity whose tumor cells are confined to the
`e ithelium of origin, widiout invasion of the basement membrane; the
`lillclihood of subsequent invasive growth is presumed to be high. See
`also drum! L'. in rim and Zebu!” c. in rim. Called also preinuanvr c.
`intraductal c.
`1.
`any
`carcinoma
`of
`the
`epithelium of
`duct.
`2. ductal c. in situ.
`the
`intraepidermal c.
`carcinoma confined within the epidermis,
`basal layer of the e idermis not being penen'ated by the proliferating
`cells, as in Bowen isease.
`intraoplderrnal squamous cell c. Bowen disease.
`intraepithelial c.
`c. in situ.
`intrahepatic bile duct c.
`cholangiocarcinoma (def. i).
`invasive Iobular c.
`an invasive type of carcinoma of the breast char
`acterized by linear growth into dcsmoplastic stroma around the terminal
`part of the lobules of mammary glands; most cases develop from lobular
`carcinoma in situ.
`yolk sac tumor.
`juvenile emhflonal c.
`KIIICI‘IitSky cell c.
`carcinoid tumor of the small or large intestinE.
`large cell c.
`a type of bronchogenic carcinoma of undifferentiated
`(anaplastlc) cells of large size, a variety of squamous cell carcinoma that
`has undergone further dcdifi'ercntiation.
`leptomeningeal c. meningeal c.
`_
`Iohular c.
`1. terminal duct c.
`2. see tabular :. in situ.
`Iobular c. In situ (LCIS)
`a type of precancerous neo lasia found in
`the lobulcs of mammary glands, usually small and wide y dispersed 9”
`that it is not palpable physically and is identified only on microscopic
`examination.
`1: progresses slowly, sometimes developing into invasive
`lobular arcinoma 10 to 15 years after first being observed. Called also
`lobular neoplastic.
`,
`lymphoepithelioma.
`iyrnphocplthelial c.
`c. medulla’re, medullant c.
`carcinoma composed mainly of EP'd‘e'
`lial elements with little or no stroma, found most often in the breaSt 31'
`thyroid gland.
`a or? ‘.’f
`moat-Iran; c. or thyroid gland, moduliary thyroid c.
`thyroid
`and carcinoma that contains amyloid deposits and pmfoui'
`cular c
`and secretes calcitonin. It occurs in both an autosomal dom-
`inant form as a component ofmultiple endocrine neoplasia, types fl and
`III, and in a nonfimilial form.
`.
`Incl-node c. malignant melanoma.
`monlngnl c.
`carcinomawas infiltration of the meninges. WWW
`larly the pin and arachnoid; it may be prior
`or secondary, es
`all?
`metastatic fi'om small—cell biog carcinoma or mast cancer. C ed “19°
`.
`c. and-W or maria a1Wm.
`M 051:1c.
`a rapidly grouting malignagr; dermal or subcutflflwus
`armor occurring on sun-exposed areas in middle-aged or older adul‘S
`
`a
`
`.._._._.___-u_-.——n-l‘I-—--hHI-"3.E.I=‘
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
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`296
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`Genome Ex. 1020
`
`Page 5 of
`
`Genome Ex. 1020
`Page 5 of 7
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`

`
`
`Ci] l'Clll 01111] {bummed
`
`ilar anastomosing trabeculae and small dense grim-
`and containin irre
`ales typical o Met ~el cells: whether these are the cells of origin is still
`under debate. Called also rrcztrcrndmflur or malarmki-r c. afrbg 311'" and
`Mfl'ko' r!!! rumor.
`basusquatnous cell c.
`matatyplcal cell c.
`mlcrocystlc odneital c.
`a rare type of adnexal carcinoma presenting
`as a hard, pale or flesh—colored plaque or nodule, usually on the face.
`especially the upper lip or paranasal area. It arises from sweat
`land
`tissue. grows slowly, and remains local, Without metastasis. CalledE also
`glowing meat duct r.
`a ty e of ductaI carcinoma in situ characterized by
`mlcmpflPlllaW c.
`a regular pattern of small _ ulbous papillatB; many tumors have combined
`micropapillary and cribrllorm‘ patterns.
`muclnous e.
`an adenomremoma that produces mucin in significant
`amounts. Called also infield c. or omrrr
`c. mucooellula re Krultcnbcrg tumor.
`tumor oi" glandular
`mucoepldermoid e.
`a malignant epithelial
`tissue. e3pecially the salivary glands, characterized by acini with
`mucus-producing cells and by
`e presence of malignant squamous
`elememS; it may occur as a low, intermediate, or high grade mall
`tancy.
`nasopharynneal e.
`a malignant tumor arisin in the epithelia lining
`of the nasopharym. canning with a high
`quency in people of
`Chinese ancestry. The Epstein-Barr virus has been implicated as :1 cans-
`ative agent.
`neuroendocrine c. of the skin Merltel cell c.
`nonlnfiltrating c.
`c. in Situ.
`a general
`non-small cell c.. non-small cell lung 1:. (NSCLC)
`term comprising all‘lung carcinomas except small cell carcinoma, and
`includin adenocarcmoma of the lung, large cell carcinoma, and squa—
`mous cc
`carcinoma.
`out cell c.
`a form of small cell carcinoma in which the cells are round
`or elongated and slightly larger than lymphocytes; they have scanty
`cytoplasm and clump poorly.
`carcinoma in which there is osreoid or
`c. ml’floans, osteold c.
`osseous memplasia of the stroma.
`Page! a. Paget disease (def. I).
`papillary c.
`carcinoma in which mere are papillary excrescences.
`papillary c. of thyroid gland, papillary thyroid c.
`the most
`common thyroid gland carcinoma, occurrin often before age 40 and
`much more in women than in men. It usua y has both papillary and
`follicular elements, grows slowly, and may remain localized for years.
`neriumpullary c.
`carcinoma arising in the immediate vicinity of the
`ampulla of Vater.
`Oil-r e.
`a solitary, nodular, sometimes ulcerated lesion of the hair
`follicle, usually on the scalp of elderly WOmen; it is frequently recurrent
`and metastasizm to regional lym h nodes.
`planoeellular c.
`squamous ce
`c.
`mlnvasive e.
`c. in site.
`
`‘
`
`‘
`Nickle cell c.
`squamous cell c. (def. l).
`c maEFnancy
`PM“?! lntraossoous c.
`a rare epithelial odonto
`Omnng in the mandible and maxilla,
`'cularly 0 male id '5. 311d
`believed to arise from odonto enic e i
`elial remnants.
`"fill cell c.
`carcinoma of
`e ten parenchynna, usually occurring in
`cram-
`mddle age or later and composed of tubular cells in v
`Edgrange-
`memi WPUOmS depend on extent of invasion. Called
`mfkfinqnemladmmrrinmamnddmnefle
`_
`Oeu- c-
`carcinoma associated with soarrin , usually an adenocarct—
`“mafif the lung; the sear may either pre
`e the carcinoma or be a
`brouc PeSponse to it.
`carcinoma of the wall of the urinary blad-
`ichlstooomal bladder e.
`liel'! usually a s usmous cell carcinoma, caused by chronic infccdon and
`mhfiofl by Stimulating homeroom called also Hibernia! c.
`““0“an e.
`a neoplasm of the mucosa of the nose and the para-
`nasal sinuses.
`carcinoma with a hard structure owing to the formation
`Milwau- o.
`“film connective tissue in the source. Called alsofibmmmm.
`We meet.
`'crocysti dncnlc.
`MIME.
`u
`e mi
`ca
`mnomaoftheseba—
`
`._
`. c. memo gland o.
`adnexxl
`‘ mglmtls. visually occurring as a slow—310mg hard yellow nodule
`I um):-
`.
`
`
`
`I Squamous cell om-imuua; two separate tumors with different morphologies in
`the pteauricular region.
`
`a type ol‘ highly malignant, mucus-secreting
`slgnot ring cell c.
`tumor usually found in the stomach or intestine; the mucus-secreting
`cells called ogre-r ring wilt are anaplasn'c.
`e. elm plan an undifferentiated carcinoma.
`skin appendage c's atlnexal c's.
`a common. highly maligA
`small cell c.. smell cell lung c. (SCLC)
`mint form of bronchogenic carcinoma in the wall of a maior bronchus,
`occurring mainl
`in middle-aged individuals with a history of tobacco
`smoking; it is ta insensitive and has small owl undifferentiated cells that
`are intensely hematoxyphilic. Metastasis to the hilum and to mediastinal
`lymph nodes is common.
`spindle cell c.
`carcinoma, usually of the squamous cell type, marked
`by fusiform development of rapidly proliferating cells.
`spinocellular e.
`squamous cell c. (def.
`l).
`squamous c.. squamous cell c.
`l. carcinoma developed From
`squamous epithelium, having cuboid cells and characterized by kera—
`tinization and often by latest-notion of intermllular bridges.
`In the
`skin, it may originate in sun—damaged areas or other pro—existing lemons.
`Initially local and superficial, the lesion may later invade and metasta-
`size. Called alsoprick r all or sphimllokrrc
`2. one of the most common
`types of bronchogenic carcinoma, generally fanning polypoid or sessile
`masses that obstruct the airways of the bronchi. It usually occurs in
`middle-aged individuals with a history of smoking. There is frequent
`invasion of blood and lymphatic motels with metastasis to regional
`lymph nodes and other sites Called also cpidmuid r.
`sweet gland c.
`hidmdenoeurcinoma.
`syringornltous o.
`Inicmcysfic adnexal c.
`terminal duet e.
`a slow“
`wing,
`locally invasive malignant neo~
`plasm composed of myoepi
`elial and ductal elements, ocmrring in
`the minor salivary glands, particularly in the palate.
`trlbeeulnr o. of the skin Merltel cell c.
`transitional cell c.
`a malignant tumor arising from a transitional
`type of Sta-stifled epithelium, usually affecting the urinary bladder.
`in
`tubular e.
`1. an adenocarcinomu in which the cells are arranged
`'e
`the form oftubules.
`2. a type ofbreest cancer in which one“ glen
`structures are fanned and infiltrate the seems; it usually develops from
`an earlier duets} carcinoma in situ and is rarely metastatic.
`undifferentiated e. of thyroid gland, undifferentiated thyroid
`c.
`anaplastic c. of thyroid gland.
`uterine corpus o.
`carcinoma ofthe corpus uteri, usually endometrial
`carcinoma, one of the most common gynecological meets; it ranges in
`malignancy from loudly invasive in metastatic.
`"menu. 1:.
`l. a vurie
`of strenuous cell carcinoma that has a
`predilection for the be mum but also affects other oral soft
`tissue and the larynx. t is a slow-g'l'ow1ng,‘ somewhat inveswe,‘ mphfi
`neoplmddierpe‘
`orverrumminappunnce. 2.3
`Lt‘iwenstelu moose
`cdbeotuseitishistologiullysimilartothe
`oral lesion.
`cinema, eJIIlo'Ium cardnominwhichdaeccflsueamgodin
`aviflomputtern,aspc.'
`pmjeciionswhiebareeovered‘ithneo—
`.
`pinticcpnlmlium;
`indtegmminmmlm
`puke-co. meander-m
`
`'
`
`’fl‘r
`.»»-..
`.I..
`
`r,
`
`(.1115;
`
`l.‘|". n,
`
`.
`“ta-l
`-' W '-" orient-mu out.
`.H _. ";-;‘;-;.-
`'i'~1.£=1‘ih~.l 7...“: ;-‘..-
`
`-
`
`.
`
`..
`
`.,
`
`297
`
`Genome Ex. 1020
`
`
`Page 6 of 7
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`Genome Ex. 1020
`Page 6 of 7
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`

`

`I
`
`carcinomata.............. .....
`
`.......
`
`
`
`flora of the nose and throat and are also isolated from blood. The
`spictgsarig’ic I”azai‘igccies that is part of the normal flora of
`the "0543 “ll
`pharynx, and also an etiologic agent of endocardins.
`.
`+
`car-dlo-cai-ro-graph (kahIJ’de-o-ki'wugral)
`[fertile-(1)
`G11;-
`time + -grapb]
`a technique by means of which l'fldlflg'raph
`5 of the '11::
`can be made at any chosen phase of Its cycle.
`pron-us]
`car-dlo-cele (kahr’de-o—sél”)
`[cordial-(1) + 't‘flf'l
`heart through a fissure of H18 diaphragm or through a Wound,
`ear-dio-een-te-sis
`(kahf’de-o’sen—te'sis) [cardio-(l) + {mm-fl m ‘
`cal puncture or incision of the heart.
`3:.
`car-dlo-eha-Ia-sla (kahH’de-o-ka—la’flw)
`phageal achalasia.
`(kahH’de-o-sur'ku-I9-tor’c) pertaining
`car-wilti-eIr-tw-la-toryr
`flow through the heart and cardiovascular system.
`car-dlo-elr-rho-sls
`(kahr’de-o-si-ro’siS)
`cardiac cirrhosis_
`candle-cute (kahr'dc-o-sit") [rardio-(l) + -tyte]