WO 2014/145958
`
`PCT/US2014/030817
`
`N437.S
`
`6
`
`100
`
`100
`
`N457.S
`
`5
`
`6
`
`100
`
`100
`
`N545
`
`5
`
`6
`
`100
`
`100
`
`N386.S
`
`5
`
`6
`
`83 3
`
`100
`
`N402.S
`
`5
`
`6
`
`83.3
`
`100
`
`N405.S
`
`4
`
`6
`
`83.3
`
`100
`
`Coprococcus comes,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Kuminococcus torques,
`Subdoligranulum variabile
`
`Coprococcus comes,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Ruminococcus torques,
`Subdoligranulum
`variabile
`
`Dorea longicatena,
`Eubacterium eligens,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Roseburia
`intestinalis, Ruminococcus
`torques
`
`Dorea longicatena.
`Eubacterium eligens,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Rosebuna
`intestinalis,
`Ruminococcus torques
`
`Coprococcus comes, Dorea
`longicatena, Eubacterium
`hallii, Eubacterium
`siraeum, Roseburia
`intestinalis, Roseburia
`inultnivorans
`
`Coprococcus comes,
`Dorea longicatena,
`Eubacterium hallii,
`Eubacterium siraeum,
`Roseburia intestinalis,
`Rosebuna tnulinivorans
`
`Alistipes putredinis,
`Eubacterium hallii,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Roscburia
`inulinivorans,
`Ruminococcus torques
`
`Coprococcus comes, Dorea
`longicatena, F,Mbacterium
`rectale, Faecalibacterium
`prausnitzii,
`Parabacteroides merdae,
`Ruminococcus torques
`
`Desulfovibrio
`desulfuricans, Eubacterium
`rectale, Faecalibacterium
`prausnitzii, Roseburia
`intestinalis, Ruminococcus
`torques, Subdoligranulum
`variabile
`
`Alist apes putredinis,
`Eubacterium hallii,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Ruminococcus torques
`
`Coprococcus comes,
`Dorea longicatena,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii,
`Parabacteroides merdae,
`Ruminococcus torques
`
`Desulfovibrio
`desullitricans,
`Eubacterium rectale,
`Faccalibacterium
`prausnitzii, Roseburia
`intestinalis,
`Ruminococcus torques,
`Subdoligranulum
`variabile
`
`(clade_262 or
`Glade 2621), (clade..444
`or clade_444i),
`(Glade 478 or Glade 478i)
`
`(Glade 262 or
`clade_262i). (clade_360
`or Glade_ 360c or
`clade_360g or clade_360h
`or clade_360i),
`(clade..444 or
`clade_4441), (clade_478
`or clade_478i),
`(clade_522 or clade_5221)
`(clade.262 or
`clade_2621), (clade_360
`or clade_360c or
`clade_360g or clade_360h
`or clade_3601),
`Glade_ 396, (clade..444 or
`clade.4441), Glade,_ 538
`
`(Glade 262 or
`Glade_ 2621), Glade. 396.
`(clade_444 or
`clade_444i), (clade_478
`or Glade_ 4781), Glade,_ 500
`
`(clade_262 or
`clade_262i), clade_286,
`(Glade_ 360 or clade..360c
`or clade_360g or
`Glade 360h or
`clade_3601), (clade..444
`or clade_444i),
`(Glade_ 478 or clade.. 4780
`
`(clade_262 or
`clade..2621), (clade..444
`or clade_444i),
`clade_445, (clade_478 or
`Glade_ 4781)
`
`489
`
`Genome Ex. 1014
`Page 794 of 1502
`
`

`

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`
`PCT/US2014/030817
`
`N415.S
`
`5
`
`6
`
`83.3
`
`100
`
`N421.S
`
`6
`
`6
`
`53.3
`
`100
`
`N422.S
`
`5
`
`6
`
`833
`
`100
`
`N423.S
`
`5
`
`6
`
`83.3
`
`100
`
`N458.S
`
`6
`
`6
`
`83.3
`
`100
`
`N459.S
`
`s
`
`6
`
`83.3
`
`100
`
`Bacteroides caccae,
`Coprococcus comes, Dorea
`longicatena, Eubacterium
`rectale, Faecalibacteriutn
`prausnitzii, Ruminococcus
`torques
`
`Bacteroides caccae,
`Coprococcus comes,
`Dorea longicatena,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii,
`Ruminococcus torques
`
`Alistipes putredinis,
`Coprococcus comes, Dorea
`longicatena, Eubacterium
`hallii, Roseburia
`inulinivorans,
`Subdoligranulum variabile
`
`Alistipes putredinis,
`Coprococcus comes,
`Dorea longicatena,
`Eubacterium hal lii,
`Roseburia inulinivorans,
`Subdoligranulum
`variabile
`
`Alistipes putredinis, Dorea
`longicatena, Eubacterium
`rectale,
`Pseudoflavonifractor
`capillosus, Roseburia
`intestinalis, Ruminococcus
`torques
`
`Alistipes putredinis,
`Dorea longicatena,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Roseburia
`intestinal is,
`Ruminococcus torques
`
`Alistipes putredinis,
`Eubacterium rectale,
`Eubactcrium siracum,
`Faecalibacterium
`prausnitzii, Ruminococcus
`torques, Subdoligranulum
`variabile
`
`Alistipes putredinis,
`Eubacterium rectale,
`Eubacterium siraeum.
`Faecalibacterium
`prausnitzii,
`Ruminococcus torques,
`Subdoligranulum
`variabile
`
`Bacteroides ovatus, Dorea
`longicatena, Eubacterium
`eligens, Eubacterium
`rectale, Faecalibacterium
`prausnitzii, Ruminococcus
`torques
`
`Bacteroides ovatus, Dorea
`longicatena, Eubacterium
`eligens, Eubacterium
`rectale, Faecalibacterium
`prausnitzii,
`Ruminococcus torques
`
`Bacteroides ovatus, Dorea
`longicatena, Eubacterium
`rectale, Faccaltbacterium
`prausnitzii, Roseburia
`intestinalis, Ruminococcus
`torques
`
`Racteroides ovatus, Dorea
`longicatena, Eubacterium
`rectale, Faecalibacterium
`prausnitzii, Roseburia
`intestinalis,
`Ruminococcus torques
`
`clade_170, (clade_262 or
`elude 262i), (clade_360
`or clade_360c or
`clade..360g or Glade,.
`or Glade. 360i),
`(Glade 444 or
`clade..4441), (Glade._ 478
`or clade_4781)
`
`(clade_262 or
`clade_262i), (clade_360
`or Glade_ 360c or
`clade_360g or clade_360h
`or clade_360i),
`Glade 396, (clade..444 or
`clade_444i), (clade_478
`or cladc_478i), cladc_500
`
`(clade_262 or
`Glade. 2621), (clade.360
`or cladc_360c or
`Glade 360g or elude_360h
`or clade_360i),
`(clade_444 or
`Glade_ 4441), Glade,_ 494,
`Glade 500
`
`(Glade 262 or
`Glade_ 2621), (Glade_ 444
`or clade_444i),
`(Glade 478 or
`clade..478i), clade..500,
`clade_538
`
`(clade_262 or
`clade..262i), (clade 360
`or clade_360c or
`Glade 360g or Glade 360h
`or Glade 3601), (clade_38
`or clade_38e or
`clade.. 8i), (clade..444 or
`clade_444i), (clade_478
`or clade_478i),
`(clade..522 or Glade_ 5221)
`
`(Glade_ 262 or
`clade_2621), (clade_360
`or clade_360c or
`Glade 360g or Glade 360h
`or clade_360i), (clade_38
`or clade_38e or
`clade_38i), (clade_444 or
`clade_444i), (clade_478
`
`490
`
`Genome Ex. 1014
`Page 795 of 1502
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`

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`
`PCT/US2014/030817
`
`or clade_478i)
`
`N493.S
`
`6
`
`6
`
`100
`
`83.3
`
`(Glade 262 or
`
`clade_262i), (clade_354
`or Glade 354e),
`
`Clostridium bartlettii,
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`Glade_ 396, (clade..444 or
`
`prausnitzii,
`
`clade_444i), (clade_478
`
`Pseudoflavonifractor
`
`or clade_478i), clade_494
`
`capillosus, Ruminococcus
`
`torques
`
`(clade.262 or
`
`Alistipcs putredinis,
`
`clade_262i), clade_396,
`
`Anaemtruncus
`
`(clade_444 or
`
`colihominis, Eubacterium
`
`N416.S
`
`6
`
`6
`
`83.3
`
`83.3
`
`Glade 444i), Glade 494,
`
`hallii, Eubacterium rectale,
`
`clade_500, (clade_516 or
`
`Pseudoflavonifractor
`
`Glade_ 516c or Glade._ 5168
`
`capillosus, Ruminococcus
`
`or elade_516h)
`
`(elade_262 or
`
`clade_262i), clade_293,
`
`(clade.360 or clade.360c
`
`or clade_360g or
`
`clade_360h or
`Glade._ 360i), (Glade._ 444
`
`or clade_444i),
`
`torques
`
`Bifidobactcrium bifidum,
`
`Dorea longicatena,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii,
`
`Pseudoflavonifractor
`
`N439.S
`
`6
`
`6
`
`83.3
`
`83.3
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Faccalibacterium
`
`prausnitzii,
`
`Pseudoflavonifractor
`
`capillosus, Ruminococcus
`
`torques
`
`Alistipes putredinis,
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Pseudoflavonifractor
`
`capillosus, Ruminococcus
`
`torques
`
`Dorea longicatena,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii,
`
`Pseudotlavonifractor
`
`capillosus, Ruminococcus
`
`N447.S
`
`1
`
`6
`
`83.1
`
`83.3
`
`N490.8
`
`5
`
`6
`
`83.3
`
`83.3
`
`(clade_478 or
`
`Glade_ 4781), clade_494
`
`capillosus, Ruminococcus
`
`torques
`
`torques
`
`Dialistcr invisus,
`
`(clade_262 or
`
`Eubacterium reetale,
`
`clade_262i), (clade_444
`
`Faecalibacterium
`
`or Glade 444i),
`
`(clade_478 or
`
`prausnitzii,
`
`Pseudoflavonifractor
`
`clade..4781), Glade_ 494,
`
`capillosus, Ruminococcus
`
`clade_506
`
`torques, Subdoligranulum
`
`(clade_262 or
`
`Glade_ 262i), Glade,_ 396,
`
`(clade_444 or
`
`clade_444i), (clade_478
`
`or clade_478i), (clade..98
`
`or clade_98i)
`
`variabile
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`
`intestinal is, Ruminococcus
`
`torques, Streptococcus
`
`australis
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii,
`
`Pseudoflavonifractor
`
`capillosus, Ruminococcus
`
`torques, Subdoligranulum
`
`variabile
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`
`intestinalis,
`
`Ruminococcus torques
`
`(clade_262 or
`
`Coprococcus comes, Dorea
`
`Coprococcus comes,
`
`Glade_ 2621), Glade,_ 271,
`
`longicatena, Eubacterium
`
`Dorea longicatena,
`
`N526
`
`5
`
`6
`
`83.3
`
`83.3
`
`(Glade 360 or Glade 360c
`
`hallii, Roseburia
`
`Eubacterium hallii,
`
`or clade_360g or
`
`clads 360h or
`
`intestinalis, Roseburia
`
`Roseburia intestinalis,
`
`inulinivorans, Rothia
`
`Roseburia inulinivorans
`
`491
`
`Genome Ex. 1014
`Page 796 of 1502
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`

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`
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`
`clade_3601), clade_396,
`
`mucilaginosa
`
`(clade_444 or clade_444i)
`
`N429.S
`
`4
`
`5
`
`100
`
`100
`
`or clade_478i),
`
`(clade_444 or
`
`clade_4441), (clade_478
`
`N433.S
`
`4
`
`5
`
`100
`
`100
`
`clade_519, (clade_522 or
`
`clade_522i)
`
`(clade_262 or
`
`clade_2621), (clade_360
`
`or clade_360c or
`
`clads 360g or clads 360h
`
`or clade_3601),
`
`(clade_444 or
`
`clade..144i), (clade..478
`
`or clade_478i)
`
`(clade_262 or
`
`clade_2621), clade_396,
`
`N448.S
`
`4
`
`5
`
`100
`
`100
`
`(clade_444 or
`
`clade_444i), (clade_478
`
`or cladc_4781)
`
`Eubacterium eligens,
`
`Eubacterium ventriosum,
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`
`inulinivorans,
`
`Subdoligranulum variabile
`
`Eubacterium eligens,
`
`Eubacterium ventriosum,
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`
`inulinivorans,
`
`Subdoligranulum
`
`variabile
`
`Coprococcus comes, Dorea
`
`longicatena, Eubacterium
`
`rectale, Faecalibacterium
`
`prausnitzii, Ruminococcus
`
`torques
`
`Coprococcus comes,
`
`Eubacterium hallii,
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`.
`.
`multnivorans,
`
`Subdoligranulum variabile
`
`Coprococcus comes,
`
`Dorea longicatena,
`
`Eubactcrium rectalc,
`
`Faecalibacterium
`
`prausnitzii,
`
`Ruminococcus torques
`
`Coprococcus comes,
`
`Eubacterium hallii,
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`
`inulinivorans,
`
`Subdoligranulum
`
`N488.S
`
`4
`
`5
`
`100
`
`100
`
`(clade_444 or
`
`(clade_262 or
`
`clade..2621), clade_396,
`
`clade_4441), (clade_478
`
`or clade_4781)
`
`(clade_262 or
`
`variabile
`
`Eubacterium hallii,
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`
`prausnitzii, Roseburia
`
`intestinalis, Ruminococcus
`
`intestinalis,
`
`torques
`
`Ruminococcus torques
`
`N508.S
`
`4
`
`5
`
`100
`
`100
`
`N509.S
`
`5
`
`5
`
`100
`
`100
`
`clade_2621), (clade_360
`
`Dorea longicatena,
`
`Dorea longicatena,
`
`or Glade 360c or
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`clade_360g or clade_360h
`
`Faecalibacterium
`
`Faecalibacterium
`
`or clade_3601),
`
`(clade_444 or
`
`prausnitzii, Roseburia
`
`prausnitzii, Roseburia
`
`intestinalis, Ruminococcus
`
`intestinalis,
`
`clade_4441), (clade_478
`
`torques
`
`Ruminococcus torques
`
`or clade_478i)
`
`(clade_262 or
`
`Glade_ 2621), (clade..360
`
`Dorea longicatena,
`
`Dorea longicatena,
`
`or clade_360c or
`Glade 360g or Glade 360h
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`Eubacterium ventriosum,
`
`Eubacterium ventriosum,
`
`or clade_3601),
`
`(clade_444 or
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, Ruminococcus
`
`prausnitzii,
`
`Glade_ 4441), (Glade_ 478
`
`torques
`
`Ruminococcus torques
`
`or clade_478i), clade_519
`
`492
`
`Genome Ex. 1014
`Page 797 of 1502
`
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`

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`
`PCT/US2014/030817
`
`(clade_262 or
`
`clade_262i), (clade_360
`
`or clade_360c or
`
`Glade 360g or Glade,. 360h
`
`N510.S
`
`5
`
`5
`
`100
`
`100
`
`or clade_360i),
`
`(Glade 444 or
`
`clade..4441), (Glade._ 478
`
`or clade_4781),
`
`(clade_522 or clade_522i)
`
`Dorea longicatena,
`
`Dorea longicatena,
`
`Eubacterium eligens,
`
`Eubacterium eligens,
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, Ruminococcus
`
`prausnitzii,
`
`torques
`
`Ruminococcus torques
`
`N511.S
`
`3
`
`5
`
`100
`
`100
`
`Coprococcus comes,
`
`Coprococcus comes,
`
`(clade _262 or
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`Glade 262i), (clade_444
`
`Faecalibacterium
`
`Faecalibacterium
`
`or clade_444i),
`
`prausnitzii, Roseburia
`
`prausnitzii, Roseburia
`
`(clade..478 or clade.4781)
`
`intestinalis, Ruminococcus
`
`intestinalis,
`
`torques
`
`Ruminococcus torques
`
`Alistipes putredinis,
`
`Alistipes putredinis,
`
`(clade_262 or
`
`Eubacterium eligens,
`
`Eubacterium eligens,
`
`Glade_ 2621), (Glade_ 478
`
`Faecalibacterium
`
`Faecalibacterium
`
`N408.S
`
`5
`
`5
`
`50
`
`100
`
`or cladc_478i),
`
`prausnitzii,
`
`prausnitzii,
`
`clade_494, clads 500,
`
`Pseudoflavonifractor
`
`Pseudollavonifractor
`
`(clade_522 or clade_522i)
`
`capillosus, Ruminococcus
`
`capillosus, Ruminococcus
`
`torques
`
`torques
`
`(clade_262 or
`
`clade_262i), (clade_360
`
`Alistipes putredinis,
`
`Alistipes putredinis,
`
`or clade_360c or
`
`Coprococcus comes, Dorea
`
`Coprococcus comes,
`
`5
`
`80
`
`Dorea longicatena,
`
`N446.S
`
`5
`
`100
`
`Glade 360g or Glade 360h
`
`longicatena, Eubacterium
`
`N451.S
`
`4
`
`5
`
`SO
`
`100
`
`N474.S
`
`5
`
`5
`
`80
`
`100
`
`N520.S
`
`5
`
`5
`
`80
`
`100
`
`or Glade._ 3601),
`
`hallii, Roseburia
`
`Eubacterium hallii,
`
`Glade_ 396, (clade_444 or
`
`inulinivorans
`
`Roseburia inulinivorans
`
`cladc_444i), cladc_500
`
`Alistipes putredinis,
`
`Alistipes putredinis,
`
`(clade..262 or
`
`Coprococcus comes,
`
`Coprococcus comes,
`
`elude --2621), elude 396,
`
`Eubacterium hallii,
`
`Eubacterium hallii,
`
`(clade_478 or
`
`Faecalibacterium
`
`Faecalibacterium
`
`clade.478i), clade..500
`
`prausnitzii, Ruminococcus
`
`prausnitzii,
`
`(clade_262 or
`
`Glade 262i), (elude 444
`
`or clade_444i),
`
`(clade_478 or
`
`clads 4781), clads 494,
`
`(clade_566 or elude...5661)
`
`torques
`
`Ruminococcus torques
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzit, Gordonibacter
`
`prausmtzii, Gordonibacter
`
`pamelaeae,
`
`pamelaeae,
`
`Pseudoflavonifractor
`
`Pseudoflavonifractor
`
`capillosus, Ruminococcus
`
`capillosus, Ruminococcus
`
`torques
`
`torques
`
`Clostridium leptum,
`
`Clostridium leptum,
`
`(clade_262 or
`
`Faecalibacterium
`
`Faecalibacterium
`
`clade_262i), (clads 478
`
`prausnitzii, Gordonibacter
`
`prausnitzii, Gordonibacter
`
`or clade_478i),
`Glade 494, Glade 537,
`
`pamelaeae,
`
`pamelaeae,
`
`Pseudoflavonifractor
`
`Pseudoflavonifractor
`
`(clade_566 or clade_5661)
`
`capillosus, Ruminococcus
`
`capillosus, Ruminococcus
`
`torques
`
`torques
`
`493
`
`Genome Ex. 1014
`Page 798 of 1502
`
`

`

`WO 2014/145958
`
`PCT/US2014/030817
`
`N521.S
`
`5
`
`5
`
`80
`
`100
`
`N535.S
`
`4
`
`80
`
`100
`
`N516.S
`
`5
`
`5
`
`60
`
`100
`
`N463.S
`
`5
`
`5
`
`100
`
`80
`
`N518.S
`
`5
`
`5
`
`100
`
`80
`
`N586
`
`3
`
`5
`
`100
`
`80
`
`N450.S
`
`5
`
`5
`
`80
`
`80
`
`(clade_262 or
`clade_262i), clade_393,
`(clade..444 or
`clade_444i), clade_445,
`(Glade 478 or Glade 478i)
`
`clade_358, clade_396,
`(clade_444 or
`clade_444i), (clade_478
`or clade_478i)
`
`clade_393, (clade_444 or
`clade_444i), clade_445,
`Glade. 521, (clade..522 or
`cladc_522i)
`
`cladc_246, (cladc_262 or
`clade_262i), (clade_444
`or clade_444i),
`(clade_478 or
`Glade 478i), Glade 576
`
`(clade..262 or
`clade_262i), (clade_354
`or cladc_354c),
`clade_396, (clade_444 or
`clade_444i), clade_494
`
`Glade_ 368, (clade..444 or
`clade_444i), (clade_478
`or clade_478i)
`
`(Glade_ 262 or
`Glade 262i), (Glade 478
`or clade_478i),
`clade_494, clade_500,
`(clade_516 or clade_516c
`or Glade_ 516g or
`clade_516h)
`
`Coprococcus catus,
`Desulfovibrio
`desulfuricans,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Ruminococcus torques
`
`Eubacterium hallii,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Subdoligranulum variabile,
`Veil lonella atypica
`
`Bilophila wadsworthia,
`Coprococcus catus,
`Desulfovibrio
`desulfuricans, Eubacterium
`cligcns, Eubactcrium
`rectale
`
`Clostridiales sp. SS3/4,
`Clostridium
`lactatifermentans,
`Faecalibacterium
`prattsnitzii, Roseburia
`inulinivorans,
`Ruminococcus torques
`Clostridium bartlettii,
`Eubacterium hallii,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`Blautia hydrogenotrophica,
`Eubacterium rectale,
`Roseburia intestinalis,
`Roseburia inulinivorans,
`Subdoligranulum variabilc
`
`Alistipcs putredinis,
`Anaerotruncus
`colihominis,
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Coprococcus catus,
`Desulfovibrio
`desulfuricans,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Ruminococcus torques
`
`Eubacterium hallii,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Subdoligranulum
`variabile, Veillonella
`atypica
`Bilophila wadsworthia,
`Coprococcus catus,
`Desulfovibrio
`desulfuricans,
`Eubactcrium cligcns,
`Eubacterium rectale
`
`Clostridium
`lactatifermentans,
`Faecalibacterium
`prausnitzii, Roseburia
`inulinivorans,
`Ruminococcus torques
`
`Eubacterium hallii,
`Eubacterium rectale,
`Pscudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Eubacterium rectale,
`Roseburia intestinalis,
`Roseburia inulinivorans,
`Subdoligranulum
`variabile
`
`Alistipes putredinis,
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`494
`
`Genome Ex. 1014
`Page 799 of 1502
`
`

`

`WO 2014/145958
`
`PCT/US2014/030817
`
`N465.S
`
`4
`
`5
`
`80
`
`80
`
`N5 I 9.S
`
`5
`
`5
`
`80
`
`80
`
`N537.S
`
`5
`
`5
`
`80
`
`80
`
`N419.S
`
`5
`
`5
`
`60
`
`80
`
`N468.S
`
`5
`
`5
`
`60
`
`80
`
`N477.S
`
`5
`
`5
`
`60
`
`80
`
`N514.S
`
`5
`
`5
`
`60
`
`60
`
`elade_168, (clade_262 or
`Glade _262i), (clade_444
`or clade..444i),
`(clade_478 or clade_478i)
`
`(clade_262 or
`clade..2621), Glade_ 401,
`(clade_444 or
`clade_444i), (clade_478
`or clade_478i), clade_494
`
`(clade_260 or clade_260c
`or clade_260g or
`clade..260h), (clade..262
`or clade_262i),
`
`(clade_444 or
`Glade_ 4441), Glade,_ 445,
`cladc_494
`
`(clade_262 or
`Glade 2621), (clade..444
`or clade_444i),
`clade_494, clade_500,
`(clade..98 or Glade_ 981)
`
`(clade..262 or
`clade_262i), clade_293,
`(clade_360 or clade_360c
`or Glade 360g or
`clade_360h or
`Glade_ 360i), Glade,_ 396,
`Glade_ 500
`
`(clade_262 or
`clade_262i), (clade_444
`or clade_444i),
`clade_494, clade_500,
`(Glade 98 or clade 98i)
`
`Glade_ 393, (clade_420 or
`clade_420t), (clade_444
`or clads_ 4441),
`(clade_522 or
`clade_522i), clade_558
`
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Prevotella
`copri, Roseburia
`intestinalis, Ruminococcus
`torques
`Eubacterium rectale,
`Faccalibacterium
`prausnitzii, Lactococcus
`lactis. Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Clostridium scindens,
`Desulfovibrio
`desulfuricans, Eubacterium
`rectale,
`
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Alistipes putredinis,
`Eubacterium rectale,
`Pscudoflavonifractor
`capillosus, Ruminococcus
`torques, Streptococcus
`salivarius
`
`Eubacterium ructalc,
`Faecalibacterium
`prausnitzii, Roseburia
`intestinalis,
`Ruminococcus torques
`
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, R.uminococcus
`torques
`
`Desulfovibrio
`desulfuricans,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Alistipes putredinis,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Alistipes putredinis,
`Bifidobacterium bifidum,
`Coprococcus comes, Dorea
`longicatena, Eubacterium
`112111'1
`
`Alistipes putredinis,
`Coprococcus comes,
`Dorea longicatena,
`Eubactcrium hal hi
`
`Alistipes putredinis,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques, Streptococcus
`thermophilus
`
`Clostridiales bacterium
`oral clone P4PA,
`Coprococcus catus,
`Eubactcrium cligcns,
`Eubacterium rectale,
`Tannerella sp.
`6_1_58FAA_CT1
`
`Alistipcs putrcdinis,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Coprococcus catus,
`Eubactcrium cligcns,
`Eubacterium rectale
`
`495
`
`Genome Ex. 1014
`Page 800 of 1502
`
`

`

`WO 2014/145958
`
`PCT/US2014/030817
`
`N382.3.
`
`5
`
`5
`
`100
`
`40
`
`N460.3
`
`3
`
`4
`
`100
`
`100
`
`N462.8
`
`3
`
`4
`
`100
`
`100
`
`(Glade 260 or Glade 260c
`
`or clade_260g or
`
`elade_260h), (clade_262
`
`or Glade _2621),
`
`(Glade 408 or Glade 4086
`
`or Glade 408d or
`
`Glade 408f or Glade 408e.
`--
`-
`
`or ciade_408h),
`
`clade 537, (clade_553 or
`
`clade__5531)
`
`(Glade 262 or
`
`clade_2621), (Glade 444
`
`or Glade_ 444i),
`
`(Glade 478 or Glade 478i)
`
`(clade_262 or
`
`clade_2621), (clade_360
`
`or clade_360c or
`
`cladc_360g or cladc_360h
`
`or clade_3601),
`
`(clade__478 or clade___4781)
`
`(Glade 262 or
`
`Clostridium hylemonae,
`
`Clostridium symbiosum,
`
`Collinsella aerofaciens,
`
`Coprococcus comes,
`
`Ruminococcus bromii
`
`Coprococcus comes,
`
`Ruminococcus bromii
`
`Coprococcus conies,
`
`Coprococcus comes,
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, R 11111i nococcus
`
`prausnitzii,
`
`torques
`
`Coprococcus comes, Dorea
`
`longicatena,
`
`Faecalibacterium
`
`prausnitzii,
`
`Subdoligranulum variabile
`
`Ruminococcus torques
`
`Coprococcus comes,
`
`Dorea longicatena,
`
`Faecalibacterium
`
`prausnitzii,
`
`Subdoligranulum
`
`variabile
`
`elade_262i), (clade 360
`
`Coprococcus comes, Dorea
`
`Coprococcus comes,
`
`or clade_360c or
`
`longicatena, Eubacterium
`
`Dorea longicatena,
`
`100
`
`100
`
`N512.3
`
`3
`
`4
`
`clade_360g or clade_360h
`
`rectale, Ruminococcus
`
`Eubacterium rectale,
`
`or Glade 360i),
`
`torques
`
`Ruminococcus torques
`
`N517.8
`
`4
`
`4
`
`100
`
`100
`
`N523.S
`
`3
`
`4
`
`100
`
`100
`
`N547.S
`
`3
`
`4
`
`100
`
`100
`
`Dorea longicatena,
`
`Dorea longicatena,
`
`Eubacterium rectale,
`
`Eubacterium rectalc,
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, Ruminococcus
`
`prausnitzii,
`
`torques
`
`Rununococcus torques
`
`Eubacterium rectale,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, Roseburia
`
`prausnitzii, Roseburia
`
`intestinalis, Ruminococcus
`
`intestinalis,
`
`torques
`
`Eubacterium rectale,
`
`Faecalibacteri ll ni
`
`prausnitzii, Ruminococcus
`
`torques, Subdoligranulum
`
`variabile
`
`Ruminococcus torques
`
`Eubacterium rectale,
`
`Faccalibacterium
`
`prausnitzii,
`
`Ruminococcus torques,
`
`Subdoligranulum
`
`variabile
`
`(Glade_ 444 or Glade_ 4441)
`
`(clade 262 or
`
`Glade 262i), (Glade 360
`
`or clade_360c or
`
`clade__360g or clade_360h
`
`or clade_360i),
`
`(clade 444 or
`
`Glade _4441), (Glade_ 478
`
`or clade 4781)
`
`(clade_262 or
`
`Glade 262i), (Glade 444
`
`or clade_444i),
`
`(Glade 478 or clade 478i)
`
`(elude_ 262 or
`
`C lade_262i), (clade_444
`
`or clade 4441),
`
`(clacle_478 or Glade_ 4781)
`
`496
`
`Genome Ex. 1014
`Page 801 of 1502
`
`

`

`WO 2014/145958
`
`PCT/US2014/030817
`
`N548.S
`
`4
`
`4
`
`100
`
`100
`
`N577.S
`
`3
`
`4
`
`100
`
`100
`
`N.581.S
`
`4
`
`4
`
`100
`
`100
`
`N585.S
`
`2
`
`4
`
`100
`
`100
`
`N616.S
`
`4
`
`4
`
`100
`
`100
`
`N466.S
`
`4
`
`4
`
`75
`
`100
`
`N469.S
`
`4
`
`4
`
`75
`
`100
`
`N480.S
`
`4
`
`4
`
`75
`
`100
`
`N482.S
`
`4
`
`4
`
`75
`
`100
`
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Clostridium leptum,
`Coprococcus comes, Dorea
`longicatena,
`Ruminococcus torques
`
`Clostridium leptum,
`Coprococcus comes,
`Dorea longicatena,
`Ruminococcus torques
`
`Eubacterium simcum,
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Eubacterium siracum,
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Roseburia
`intestinalis, Roseburt a
`inulinivorans
`
`Coprococcus comes, Dorea
`longicatena, Eubacterium
`hallii, Faecalibacterium
`prausnitzii
`
`Eubacterium rectale,
`Faccalibacteri Urn
`prausnitzii, Roseburia
`intestinalis, Roseburia
`inulinivorans
`
`Coprococcus comes,
`Dorea longicatena,
`Eubacterium Milli,
`Faecalibacterium
`prausnitzii
`
`Alistipes putredinis,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Alistipes putredinis,
`Eubacterium rectale,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Alistipes putredinis,
`Coprococcus comes, Dorea
`longicatena, Eubacterium
`hallii
`
`Alistipes putredinis,
`Coprococcus comes,
`Dorea longicatena,
`Eubacterium hallii
`
`Alistipes putredinis,
`Faecalibacterium
`prausnitzii, Ruminococcus
`bromii, Ruminococcus
`torques
`
`Alistipes putredinis,
`Eubacterium eligens,
`Faecalibacterium
`prausnitzii, Ruminococcus
`torques
`
`Alistipes putredinis,
`Faecalibacterium
`prausnitzii,
`Ruminococcus bromii,
`Ruminococcus torques
`
`Alistipes putredinis,
`Eubacterium eligens,
`Faecalibacterium
`prausnitzii,
`Ruminococcus torques
`
`(clade_262 or
`clade_262i), (clade_444
`or clade_444i),
`(Glade_ 478 or
`clade_478i), clade_494
`
`(clade_262 or
`Glade_ 262i), (Glade 360
`
`or Glade 360c or _
`clade_360g or clade_360h
`or Glade_ 360i), clade_537
`
`(clade_262 or
`clade_2621), (clade_478
`or Glade_ 4781),
`clade_494, clade_538
`
`(Glade_ 444 or
`clade_444i), (clade_478
`or clade_478i)
`
`(Glade. 262 or
`Glade 2621), (clade_360
`or clade_360c or
`Glade_ 360g or Glade,_ 360h
`or clade_360i),
`clade_396, (clade_478 or
`Glade 478i)
`
`(clade_262 or
`clade_262i), (clade_444
`or Glade._ 4441),
`clade_494, cladc_500
`
`(clade_262 or
`clade_262i), (clade_360
`
`or Glade 360c or_
`clade_360g or clade_360h
`or Glade._ 3601),
`clade_396, Glade 500
`
`(clade_262 or
`clade_262i), (clade_478
`or Glade 478i),
`clade_500, clade_537
`
`(clade_262 or
`Glade_ 2621), (Glade 478
`or clade_478i),
`clade_500, (clade_522 or
`elade.. 5220
`
`497
`
`Genome Ex. 1014
`Page 802 of 1502
`
`

`

`WO 2014/145958
`
`PCT/US2014/030817
`
`N484.S
`
`4
`
`4
`
`75
`
`100
`
`(clade__262 or
`
`clade_ 262i), clade__396,
`
`(C lade478 or
`
`clads_ 4781), Glade_ 500
`
`clade__393, (clade___444 or
`
`N515.S
`
`4
`
`4
`
`75
`
`100
`
`clade_4441), clade_521,
`
`(Glade_ 522 or clade_ 522i)
`
`Alistipes putredinis,
`
`Alistipes putredinis,
`
`Eubacterium hallii,
`
`Eubacterium hallii,
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, Ruminococcus
`
`prausnitzii,
`
`torques
`
`Ruminococcus torques
`
`Bilophila wadsworthia,
`
`Bilophila wadsworthia,
`
`Coprococcus catus,
`
`Coprococcus cams,
`
`Eubacterium eligens,
`
`Eubacterium eligens,
`
`Eubacterium rectale
`
`Eubacterium rectale
`
`Desulfovibrio
`
`Desulfavibrio
`
`N5:33.S
`
`4
`
`4
`
`75
`
`100
`
`(clade_262 or
`
`desulfuricans, Eubacterium
`
`desulfuricans,
`
`Glade 262i), (Glade 444
`
`rectale,
`
`Eubacterium
`
`rectale,
`
`or clade 444i),
`
`Pseudoflavonifractor
`
`Pseudollavonicractor
`
`clade_445, clade_494
`
`capillosus, Ruminococcus
`
`capillosus, Ruminococcus
`
`torques
`
`torques
`
`N709
`
`4
`
`4
`
`75
`
`100
`
`(c lade444 or
`
`(Glade_ 262 or
`
`Glade_ 262i), Glade_ 396,
`
`clade_444i), (clade_566
`
`or clade_5660
`
`(clade_262 or
`
`Coprococcus comes,
`
`Coprococcus comes,
`
`Eubacterium hallii,
`
`Eubacterium hallii,
`
`Ciordonibacter pamelaeae,
`
`Ciordonibacter pamelaeae,
`
`Roseburia inulinivorans
`
`Roseburia inulinivorans
`
`Coprococcus comes,
`
`Coprococcus comes,
`
`N730
`
`4
`
`4
`
`75
`
`100
`
`clade_2621), clade_286,
`
`Eubacterium hallii,
`
`Eubacterium hallii,
`
`Glade_ 396, (clade_._444 or
`
`Parabacteroides merdae,
`
`Parabacteroides merdae,
`
`Glade. 4441)
`
`Roseburia inulinworaus
`
`Roseburia inulinivorans
`
`clade 170, (clade_262 or
`
`Bacteroides caccae,
`
`Bacteroides caccae,
`
`Alistipes putredinis,
`
`Alistipes putredinis,
`
`N478.S
`
`4
`
`4
`
`50
`
`100
`
`Glade _2621), (Glade_ 478
`
`Faecalibacterium
`
`Faecalibacteriu.m
`
`or Glade_ 478i), clade_500
`
`prausnitzii, Ruminococcus
`
`prausnitzii,
`
`torques
`
`Ruminococcus torques
`
`N572.S
`
`4
`
`4
`
`50
`
`100
`
`clade_4441), clade_445,
`
`rectale, Faecalibacterium
`
`clade_ 286, (clade _444 or
`
`desulfuricans, Eubacterium
`
`Desulfovibrio
`
`(Glade._ 478 or clade_478i)
`
`prausnitzii,
`
`Parabacteroides merdae
`
`Desuirovibrio
`
`desulfuricans,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii,
`
`Parabacteroides merdae
`
`N400.S
`
`4
`
`4
`
`100
`
`75
`
`(clade_262 or
`
`clade 262i), (clade_408
`
`or Glade _408b or
`
`clade_408d or clade_408f
`
`or clade_408g or
`
`Glade_ 408h), (clade 444
`
`or clade_4441),
`
`(Glade_ 478 or Glade_ 4781)
`
`(Glade 262 or
`
`Glade 2621), (clade 354
`
`N543.S
`
`4
`
`4
`
`100
`
`75
`
`or clade__354e),
`
`(clade_ 478 or
`
`clade 4781), clade 494
`
`498
`
`Clostridium symbiosum,
`
`Coprococcus comes,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii
`
`Coprococcus comes,
`
`Eubacterium rectale.
`
`Faecalibacterium
`
`prausnitzii
`
`Clostridium bartlettii,
`
`Faecalibacterium
`
`prausnitzii,
`
`Pseudoflavonifractor
`
`capillosus, Ruminococcus
`
`torques
`
`Faecalibacterium
`
`prausnitzii,
`
`Pseudoflavonifractor
`
`capillosus, Ruminococcus
`
`torques
`
`Genome Ex. 1014
`Page 803 of 1502
`
`

`

`WO 2014/145958
`
`PCT/US2014/030817
`
`N582.5
`
`4
`
`4
`
`100
`
`75
`
`N621.5
`
`4
`
`4
`
`100
`
`75
`
`N689
`
`4
`
`4
`
`100
`
`75
`
`N769
`
`4
`
`4
`
`100
`
`75
`
`N481.5
`
`4
`
`4
`
`75
`
`75
`
`N525.S
`
`4
`
`4
`
`75
`
`75
`
`N528.5
`
`4
`
`4
`
`75
`
`75
`
`Clostridium symbiosum,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii, Ruminococcus
`torques
`
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii,
`Ruminococcus torques
`
`Anaerostipes caccae,
`Eubacterium hallii,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii
`
`Eubacterium hallii,
`Eubacterium rectale,
`Faecalibacterium
`prausnitzii
`
`Clostridium
`methylpentosum,
`Coprococcus comes,
`Eubacterium hallii,
`Roseburia inulinivorans
`
`Clostridium scindens,
`Faecalibacterium
`prattsnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Alistipes putredinis,
`Collinsella aerofaciens,
`Faecalibacterium
`prausnitzii, Ruminococcus
`torques
`
`Anaerostipes caccae,
`Desulfovibrio
`desulfuricans,
`Pseudoflavonifractor
`capillostts, Ruminococcus
`torques
`
`Clostridium symbiosum,
`Desulfovibrio
`desulfuricans,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Coprococcus comes,
`Eubactcrium hallii,
`Roseburia inulinivorans
`
`Faecalibacterium
`prausnitzii,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torqucs
`
`Alistipes putredinis,
`Faecalibacterium
`prausnitzii,
`Ruminococcus torques
`
`Desulfovibrio
`desulfuricans,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`Dcsulfovibrio
`desulfuricans,
`Pseudoflavonifractor
`capillosus, Ruminococcus
`torques
`
`(clade_262 or
`clade_262i), (elude 408
`or clade_408b or
`clade..408d or clade...4081
`or clade_408g or
`Glade 408h), (Glade 444
`or Glade_ 4441),
`(clade_478 or clade_478i)
`
`clade_396, (clade_408 or
`clade_408b or clade_408d
`or elude 4081 or
`clade_408g or
`clade_408h), (clade_444
`or clade..4441),
`(clade_478 or clade_478i)
`
`(clade_262 or
`clade_262i), clade_396,
`(clade..444 or
`cladc_444i), (cladc_516
`or elude 516c or
`clade_516g or
`clade_516h)
`
`(elade_260 or elade_260e
`or clade_260g or
`clade_260h), (clade_262
`or elude 262i),
`(clade..478 or
`clade_478i), clade_494
`
`(elude 262 or
`clade_262i), (clade_478
`or clade..478i),
`clade_500, (clade_553 or
`clade_553i)
`(clade_262 or
`Glade_ 262i), (clado..408
`or clade_408b or
`clade_408d or clade_408f
`or Glade_ 408g or
`Glade 408h), Glade 445,
`clade_494
`
`(clade_262 or
`Glade._ 2621), (Glade._ 408
`or clade_408b or
`clade_408d or clade_408f
`or clade_408g or
`clade_408h), clade_445,
`elude_ 494
`
`499
`
`Genome Ex. 1014
`Page 804 of 1502
`
`

`

`WO 2014/145958
`
`PCT/US2014/030817
`
`N534.S
`
`4
`
`4
`
`75
`
`75
`
`(clade_262 or
`
`clade_262i), (clade_444
`
`or clade_444i),
`
`(clade..478 or
`
`clade_478i), (clade_65 or
`
`Glade 65e)
`
`Bac teroides fragilis,
`
`Eubacterium rectale,
`
`Faecalibacterium
`
`prausnitzii, Ruminococcus
`
`torques
`
`Clostridium leptum,
`
`Glade_ 396, (clade...478 or
`
`Eubacterium hallii,
`
`N574.S
`
`4
`
`4
`
`75
`
`75
`
`clade_478i), clade_537,
`
`l'accalibacterium
`
`(clade_98 or clade_98i)
`
`prausnitzii, Streptococcus
`
`N580.S
`
`4
`
`4
`
`75
`
`75
`
`(clade_444 or
`
`(clade_262 or
`
`clade_262i), clade_396,
`
`N590.S
`
`1
`
`4
`
`75
`
`75
`
`clade..444i), (clade..98 or
`
`clade_98i)
`
`Glade 401, (clade_478 or
`
`clade_478i), clade_485
`
`Eubac ten= rectale,
`
`Faecalibacterium
`
`prausnitzii,
`
`Rurninococc us torques
`
`Clostridium leptum,
`
`Eubacterium hallii,
`
`Faecalibacterium
`
`prausnitzii
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Ruminococcus torques
`
`thermophilus
`
`Eubacterium hallii,
`
`Eubacterium rectale,
`
`Ruminococcus torques,
`
`Streptococcus australis
`
`Faecalibacterium
`
`Faecalibacterium
`
`prausnitzii, Holdemania
`
`prausnitzii, Holdemania
`
`filiformis, Lactococcus
`
`fili fonnis,
`
`lactis, Subdoligranulum
`
`Subdoligranulum
`
`variabile
`
`variabile
`
`4
`
`4
`
`75
`
`75
`
`(clade_262 or
`
`Glade _262i), clade_401,
`
`Eubacterium rectale,
`
`Lactococcus lactis,
`
`Eubacterium rectale,
`
`Pseudollavonifractor
`
`N591.S
`
`N597.S
`
`3
`
`4
`
`75
`
`75
`
`N664
`
`4
`
`4
`
`75
`
`75
`
`(clade_444 or
`
`clade..444i), c lade. 494
`
`Pseudollavonifractor
`
`capillosus, Ruminococcus
`
`torques
`
`capillosus, Ruminococcus
`
`torques
`
`(clade_478 or
`
`clade_478i), (clade_522
`
`or Glade_ 522i), (Glade_ 98
`
`or clade_98i)
`
`(clade_360 or clade_360c
`
`or clade_360g or
`
`Glade 360h or
`
`clade_360i), (Glade 378