March2, 2010|vol. 107 | no. 9 | pp. 3943-4486 Ne
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`www.pnas.org
`honeyceedingsa“ National AcademyofSciences ofthe United States ofAmerica
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`MAR °9 2010
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`Proceedingsof the National Academy of Sciencesofthe United States of America
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`
`
` March 2, 2010 | vol. 107 | no. 9 | 3943-4486
`
`Proceedings of the National AcademyofSciences of the UnitedStates of America
`
`www.pnas.org
`
`Cover image: Pictured are residential burglary hotspots in a portion of Los Angeles, Cali-
`fornia. Martin B.Shortet al. report on reaction-diffusion models indicating that spatial crime
`patterns come in two fundamental types: supercritical hotspots, which emerge from small
`stochastic fluctuations in crime, and subcritical hotspots, which emerge from large spikes in
`crime. The authors suggestthat policing tactics focused on supercritical hotspots can displace
`the hotspot into a ring structure, which then breaks up into new hotspots, whereastactics
`focused on subcritical hotspots mayresult in lasting crime dissipation. See the article by Short
`et al. on pages 3961-3965. Image courtesy of P. Jeffrey Brantingham.
`
`From the Cover
`
`3961 Dissipation and displacement of crime
`
`3998 Driving liquid crystal reorganization
`
`4099 Folding mechanism of membrane proteins
`
`4111 Motor and motility cycle of kinesin
`
`4377 Genetic integration of cholera
`
`C
`
`t
`t
`on en S
`
`
`
`3943
`
`In This Issue
`
`E29 Distant friends, close strangers? Inferring friendships
`from behavior
`jimi adams
`
`E31 Reply to adams: Multi-dimensional edge inference
`Nathan Eagle, Aaron Clauset, Alex (Sandy) Pentland,
`and David Lazer
`
`COMMENTARIES
`
`3945 Liquid crystals énable chemoresponsive reconfigurable
`colloidal self-assembly
`Ivan I. Smalyukh
`=> See companion article on page 3998
`
`3947 Membraneprotein folding makes the transition
`Paula J. Booth and Jane Clarke
`
`= See companion article on page 4099
`
`SE Free online through the PNAS openaccess option.
`
`‘
`
`L
`
`3949 Kinesin motoractivation: Microtubules pull
`the switches
`Franck Fourniol and Carolyn A. Moores
`=> See companion article on page 4111
`
`3951 Efficiency and specificity of CTX chromosomal
`integration: dif makesall the difference
`E. Fidelma Boyd
`> See companion article on page 4377
`
`
`3953 Vaccination with partial knowledge of external
`effectiveness
`Charles F, Manski
`
`
`Diadeteemadsoiies
`
`3961 Dissipation and displacement of hotspots in
`reaction-diffusion models of crime
`Martin B. Short, P. Jeffrey Brantingham, Andrea L.
`Bertozzi, and George E.Tita
`
`APPLIED PHYSICAL SCIENCES
`
`3966 Systemic antiangiogenic activity of cationic poly-
`L-lysine dendrimer delays tumor growth
`Khuloud T. Al-Jamal, Wafa’ T. Al-Jamal, Simon Akerman,
`Jennifer E. Podesta, Acelya Yilmazer, John A. Turton,
`Alberto Bianco, Neil Vargesson, Chryso Kanthou, Alexander
`T. Florence, Gillian M. Tozer, and Kostas Kostarelos
`
`PNAS | March 2, 2010 |
`
`vol. 107 | no.9 |
`
`iii-viii
`
`

`

`3972
`
`3977
`
`3982
`
`3988
`
`3994
`
`4299
`
`4341
`
`4069
`
`3998
`
`4004
`
`4010
`
`Field-effect-tuned lateral organic diodes
`Bal Mukund Dhar, Geetha S. Kini, Guogiang Xia, Byung
`‘Jun Jung, Nina Markovic, and Howard E. Katz
`
`Learning as a phenomenonoccurring in a
`critical state
`
`Lucilla de Arcangelis and Hans J. Herrmann
`
`CHEMISTRY
`
`Insight into the mechanism of an iron dioxygenase by
`resolution of steps following the Fe'Y=O species
`Piotr K. Grzyska, Evan H. Appelman, Robert P. Hausinger,
`and Denis A. Proshlyakov
`
`Targeted metabolic labeling of yeast N-glycans with
`unnatural sugars
`MarkA. Breidenbach, Jennifer E. G. Gallagher, David S.
`King, Brian P. Smart, Peng Wu, and Carolyn R. Bertozzi
`
`A model for the CO-inhibited form of [NiFe]
`hydrogenase: synthesis of (CO)3Fe(u-S‘Bu)3Ni{SC;H3-2,6-
`(mesityl)2} and reversible CO addition at the Ni site
`Yasuhiro Ohki, Kazunari Yasumura, Masaru Ando, Satoko
`Shimokata, and Kazuyuki Tatsumi
`
`Disruption of angiogenesis and tumor growth with an
`orally active drug that stabilizes the inactive state of
`PDGFRB/B-RAF
`Eric A. Murphy, David J. Shields, Konstantin Stoletov, Elena
`Dneprovskaia, Michele McElroy, Joshua I. Greenberg, Jeff
`Lindquist, Lisette M. Acevedo, Sudarshan Anand, Bharat
`Kumar Majeti, Igor Tsigelny, Adrian Saldanha, Breda
`Walsh, Robert M. Hoffman, Michael Bouvet, Richard L.
`Klemke, Peter K. Vogt, Lee Arnold, Wolfgang Wrasidlo,
`and David A. Cheresh
`
`Only two amino acids are essential for cytolytic toxin
`recognition of cholesterol at the membrane surface
`Allison J. Farrand, Stephanie LaChapelle, Eileen M. Hotze,
`Arthur E. Johnson, and Rodney K. Tweten
`
`COMPUTER SCIENCES
`
`Markov random fields reveal an N-terminal double
`beta-propeller motif as part of a bacterial hybrid
`two-component sensor system
`Matt Menke, Bonnie Berger, and Lenore Cowen
`
`ENGINEERING
`
`Chemoresponsive assemblies of microparticles at liquid
`crystalline interfaces
`Gary M. Koenig,Jr., I-Hsin Lin, and Nicholas L. Abbott
`> See Commentary on page 3945
`
`Ultrahigh-throughputscreening in drop-based
`microfluidics for directed evolution
`Jeremy J. Agresti, Eugene Antipov, Adam R. Abate,
`Keunho Ahn, Amy C. Rowat, Jean-Christophe Baret,
`Manuel Marquez, Alexander M. Klibanov, Andrew
`D.Griffiths, and David A. Weitz
`
`GEOLOGY
`
`The Murray Springs Clovis site, Pleistocene extinction,
`and the question of extraterrestrial impact
`C. Vance Haynes, Jr., J. Boerner, K. Domanik, D. Lauretta,
`J. Ballenger, and J. Goreva
`
`iv
`
`| www.pnas.org
`
`PHYSICS
`
`4016 Abduction and asylum in thelives of transcription factors
`Anat Burger, Aleksandra M. Walczak, and Peter G. Wolynes
`
`4141 Membranecurvature controls dynamin polymerization
`se Aurélien Roux, Gerbrand Koster, Martin Lenz, Benoit
`Sorre, Jean-Baptiste Manneville, Pierre Nassoy,
`and Patricia Bassereau
`
`SOCIALSCIENCES
`aS a =
`
`4
`= a ~
`
`ECONOMIC SCIENCES
`
`3953 Vaccination with partial knowledge of external
`effectiveness
`Charles F. Manski
`
`SOCIAL SCIENCES
`
`3961 Dissipation and displacement of hotspots in reaction-
`diffusion models of crime
`Martin B. Short, P. Jeffrey Brantingham, Andrea L. Bertozzi,
`and George E. Tita
`
`
`BIOLOGICALSCIENCE
`
`—
`
`BIOCHEMISTRY
`
`4022 Arole for a bacterial ortholog of the Ro autoantigen in
`starvation-induced rRNA degradation
`Elisabeth J. Wurtmann and Sandra L. Wolin
`
`4028 Severe oxidative stress induces protein mistranslation
`through impairment of an aminoacyl-tRNA synthetase
`editing site
`Jigiang Ling and Dieter S6ll
`
`4034 Structural basis for the cooperative interplay between
`the two causative gene products of combined factor V
`and factor VIII deficiency
`MihoNishio, Yukiko Kamiya, Tsunehiro Mizushima, Soichi
`Wakatsuki, Hiroaki Sasakawa, Kazuo Yamamoto, Susumu
`Uchiyama, Masanori Noda, Adam R. McKay, Kiichi Fukui,
`Hans-Peter Hauri, and Koichi Kato
`
`4040 Thestructure of the harmonin/sans complex reveals an
`unexpected interaction mode of the two Usher
`syndromeproteins
`Jing Yan, Lifeng Pan, Xiuye Chen, Lin Wu,
`and Mingjie Zhang
`
`4046
`
`4051
`
`Pathwayof ATPutilization and duplex rRNA unwinding
`by the DEAD-box helicase, DbpA
`Arnon Henn, Wenxiang Cao, Nicholas Licciardello, Sara E.
`Heitkamp, David D. Hackney, and Enrique M. De La Cruz
`
`Stem cell-specific activation of an ancestral myc
`protooncogene with conservedbasic functions in the
`early metazoan Hydra
`Markus Hartl, Anna-Maria Mitterstiller, Taras Valovka,
`Kathrin Breuker, Bert Hobmayer, and Klaus Bister
`
`4057 Yeast Tdp1 regulates the fidelity of nonhomologous
`endjoining
`Karim Bahmed, Karin C. Nitiss, and John L. Nitiss
`
`

`

`4063
`
`3982
`
`4016
`
`4069
`
`4075
`
`4081
`
`4087
`
`4093
`
`4099
`
`Cell-specific differences in the requirements for
`translation quality control
`Noah M. Reynolds, Jiqiang Ling, Herve Roy, Rajat Banerjee,
`Sarah E. Repasky, Patrice Hamel, and Michael Ibba
`
`BIOPHYSICS AND COMPUTATIONAL BIOLOGY
`
`Insight into the mechanism of an iron dioxygenase by
`resolution of steps following the Fe'Y=O species
`Piotr K. Grzyska, Evan H. Appelman, Robert P. Hausinger,
`and Denis A. Proshlyakov
`
`Abduction and asylumin thelives of transcription factors
`Anat Burger, Aleksandra M. Walczak, and Peter G. Wolynes
`Markov random fields reveal an N-terminal double
`beta-propeller motif as part of a bacterial hybrid
`two-component sensor system
`Matt Menke, Bonnie Berger, and Lenore Cowen
`
`Ketosteroid isomerase provides further support for the
`idea that enzymes workbyelectrostatic preorganization
`Shina C. L. Kamerlin, Pankaz K. Sharma, Zhen T. Chu,
`and Arieh Warshel
`
`PH (low)insertion peptide (pHLIP) inserts across a lipid
`bilayer as a helix and exits by a different path
`Oleg A. Andreev, Alexander G, Karabadzhak, Dhammika
`Weerakkody, Gregory O. Andreev, Donald M. Engelman,
`and Yana K. Reshetnyak
`
`Function and specificity of synthetic Hox transcription
`factors in vivo
`
`Dimitrios K. Papadopoulos, Vladana Vukojevic, Yoshitsugu
`Adachi, Lars Terenius, Rudolf Rigler, and Walter J. Gehring
`
`Quantitative study of synthetic Hox transcription
`factor—-DNAinteractionsin live cells
`
`Viadana Vukojevic, Dimitrios K. Papadopoulos, Lars
`Terenius, Walter J. Gehring, and Rudolf Rigler
`
`Thetransition state for folding of an outer membrane
`protein
`Gerard H. M. Huysmans, Stephen A. Baldwin, David J.
`Brockwell, and Sheena E. Radford
`> See Commentary on page 3947
`
`4135
`
`4141
`
`4147
`
`4153
`
`4159
`
`4165
`
`4170
`
`Electrostatics of aquaporin and aquaglyceroporin
`channels correlates with their transport selectivity
`Romina Oliva, Giuseppe Calamita, Janet M. Thornton,
`and Marialuisa Pellegrini-Calace
`
`CELL BIOLOGY
`
`Membranecurvature controls dynamin polymerization
`Aurélien Roux, Gerbrand Koster, Martin Lenz, Benoit
`Sorre, Jean-Baptiste Manneville, Pierre Nassoy,
`and Patricia Bassereau
`
`Pharmaceutical modulation of canonical Wnt
`signaling in multipotent stromal cells for improved
`osteoinductive therapy
`Ulf Krause, Sean Harris, Angela Green, Joni Ylostalo,
`Suzanne Zeitouni, Narae Lee, and Carl A. Gregory
`
`ATMsignals to TSC2 in the cytoplasm to regulate
`mTORC1 in response to ROS
`~
`Angela Alexander, Sheng-Li Cai, Jinhee Kim, Adrian
`Nanez, Mustafa Sahin, Kirsteen H. MacLean, Ken Inoki,
`Kun-Liang Guan, Jianjun Shen, Maria D. Person,
`Donna Kusewitt, Gordon B. Mills, Michael B. Kastan,
`and Cheryl Lyn Walker
`
`Centromere-localized breaks indicate the generation
`of DNA damage bythe mitotic spindle
`Astrid Alonso Guerrero, Mercedes Cano Gamero, Varvara
`Trachana, Agnes Fiitterer, Cristina Pacios-Bras, Nuria
`Panadero Diaz-Concha, Juan Cruz Cigudosa, Carlos
`Martinez-A., and Karel H. M. van Wely
`
`Transcriptional corepressor TLE1 functions with Runx2
`in epigenetic repression of ribosomal RNA genes
`Syed A. Ali, Sayyed K. Zaidi, Jason R. Dobson, Abdul R.
`Shakoori, Jane B. Lian, Janet L. Stein, Andre J. van
`Wijnen, and Gary S. Stein
`
`Structure of sterol aliphatic chains affects yeast cell
`shape and cell fusion during mating
`Pablo S. Aguilar, Maxwell G. Heiman, Tobias C. Walther,
`Alex Engel, Dominik Schwudke, Nathan Gushwa,
`Teymuras Kurzchalia, and Peter Walter
`
`4105
`RNA looping by PTB: Evidence using FRET and NMR
`spectroscopyforarole in splicing repression
`4176
`Twoisoforms of human RNA polymeraseIII with
`Rajan Lamichhane, Gerrit M. Daubner, Judith
`specific functions in cell growth and transformation
`Thomas-Crusells, Sigrid D. Auweter, Cristina Manatschal,
`Valérie Haurie, Stéphanie Durrieu-Gaillard, Héléne
`Keyunna S. Austin, Oksana Valniuk, Frédéric H.-T. Allain,
`Dumay-Odelot, Daniel Da Silva, Christophe Rey, Martina
`and David Rueda
`Prochazkova, Robert G. Roeder, Daniel Besser,
`and Martin Teichmann
`
`4111
`
`An atomic-level mechanism for activation of the kinesin
`molecular motors
`Charles V. Sindelar and Kenneth H. Downing
`=> See Commentary on page 3949
`
`4117
`
`4123
`
`4129
`
`Heterospecies partition analysis reveals binding
`curve and stoichiometry of protein interactions in
`living cells
`Bin Wu, Yan Chen, and Joachim D, Miiller
`
`Independentinitiation of primary electron transfer in
`the two branches of the photosystem | reaction center
`Marc G. Miiller, Chavdar Slavov, Rajiv Luthra, Kevin E.
`Redding, and Alfred R. Holzwarth
`
`Surface-coupled proton exchange of a membrane-bound
`proton acceptor
`Tor Sandén, Lina Salomonsson, Peter Brzezinski,
`and Jerker Widengren
`
`4182
`
`4188
`
`Diacylglycerol kinase o mediates HGF-induced Rac
`activation and membraneruffling by regulating
`atypical PKC and RhoGDI
`Federica Chianale, Elena Rainero, Cristina Cianflone,
`Valentina Bettio, Andrea Pighini, Paolo E. Porporato,
`Nicoletta Filigheddu, Guido Serini, Fabiola Sinigaglia,
`Gianluca Baldanzi, and Andrea Graziani
`
`Amyloidogenic light chains induce cardiomyocyte
`contractile dysfunction and apoptosis via a non-
`canonical p38a MAPK pathway
`Jianru Shi, Jian Guan, Bingbing Jiang, Daniel A. Brenner,
`Federica del Monte, Jennifer E. Ward, Lawreen H.
`Connors, Douglas B. Sawyer, Mare J. Semigran, Thomas E.
`Macgillivray, David C. Seldin, Rodney Falk,
`and Ronglih Liao
`
`PNAS | March 2, 2010 | vol. 107
`
`| no.9 | v
`
`

`

`4194
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`4212
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`4218
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`4224
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`4230
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`4236
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`4242
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`4248
`
`4254
`
`Macrophage Wnt7bis critical for kidney repair
`and regeneration
`Shuei-Liong Lin, Bing Li, Sujata Rao, Eun-Jin Yeo, Thomas
`E. Hudson, Brian T. Nowlin, Huaying Pei, Lijun Chen,
`Jie J. Zheng, Thomas J. Carroll, Jeffrey W. Pollard, Andrew
`P. McMahon, Richard A. Lang, and Jeremy S. Duffield
`
`Membrane-anchoredserine protease matriptase
`regulates epithelial barrier formation and permeability
`in the intestine
`Marguerite S. Buzza, Sarah Netzel-Arnett, Terez Shea-
`Donohue, Aiping Zhao, Chen-Yong Lin, Karin List, Roman
`Szabo, Alessio Fasano, Thomas H. Bugge, and Toni M. Antalis
`
`Regulation of synaptic vesicle recycling by complex
`formation betweenintersectin 1 and the clathrin
`adaptor complex AP2
`Arndt Pechstein, Jelena Bacetic, Ardeschir Vahedi-Faridi,
`Kira Gromova, Anna Sundborger, Nikolay Tomlin, Georg
`Krainer, Olga Vorontsova, Johannes G. Schafer, Simen G.
`Owe, Michael A. Cousin, Wolfram Saenger, Oleg Shupliakov,
`and Volker Haucke
`
`N-cadherin ligation, but not Sonic hedgehog binding,
`initiates Cdo-dependent p38a/f MAPKsignaling in
`skeletal myoblasts
`Min Lu and Robert S. Krauss
`
`DEVELOPMENTAL BIOLOGY
`
`Regulation of PI3-kinase/Akt signaling by muscle-
`enriched microRNA-486
`Eric M. Small, Jason R. O'Rourke, Viviana Moresi, Lillian B.
`Sutherland, John McAnally, Robert D. Gerard, James A.
`Richardson, and Eric N. Olson
`
`Spatiotemporal compartmentalization of key
`physiological processes during muscle precursor
`differentiation
`Ertugrul M. Ozbudak, Olivier Tassy, and Olivier Pourquié
`
`Caspase 3/caspase-activated DNase promotecell
`differentiation by inducing DNA strand breaks
`Brian D. Larsen, Shravanti Rampalli, Leanne E. Burns, Steve
`Brunette, F. Jeffrey Dilworth, and Lynn A. Megeney
`
`ECOLOGY
`
`Cycles, phase synchronization, and entrainment in
`single-species phytoplankton populations
`Thomas M. Massie, Bernd Blasius, Guntram Weithoff, Ursula
`Gaedke, and Gregor F, Fussmann
`
`ENVIRONMENTAL SCIENCES
`
`The tolerance-fecundity trade-off and the maintenance
`_ of diversity in seed size
`Helene C. Muller-Landau
`
`EVOLUTION
`
`Fitness flux and ubiquity of adaptive evolution
`Ville Mustonen and Michael Lassig
`
`Selective loss of polymorphic mating typesis associated
`with rapid phenotypic evolution during morphic
`speciation
`Ammon Corl, Alison R. Davis, Shawn R. Kuchta,
`and Barry Sinervo
`
`vi
`
`WWW.pnas.org
`
`4260
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`3988
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`4264
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`4270
`
`4275
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`4281
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`4287
`
`4293
`
`3953
`
`3966
`
`4299
`
`Phenotypic plasticity facilitates recurrent rapid
`adaptation to introduced predators
`Alison G, Scoville and Michael E. Pfrender
`
`GENETICS
`
`Targeted metabolic labeling of yeast N-glycans with
`unnatural sugars
`Mark A. Breidenbach, Jennifer E. G. Gallagher, David S.
`King, Brian P. Smart, Peng Wu, and Carolyn R. Bertozzi
`
`Natural variation for seed dormancy in Arabidopsis is
`regulated by additive genetic and molecular pathways
`Leénie Bentsink, Johannes Hanson, Corrie J. Hanhart, Hetty
`Blankestijn-de Vries, Colin Coltrane, Paul Keizer, Mohamed
`El-Lithy, Carlos Alonso-Blanco, M. Teresa de Andrés,
`Matthieu Reymond, Fred van Eeuwijk, Sjef Smeekens,
`and Maarten Koornneef
`
`Multilocus tetrasomic linkage analysis using hidden
`Markovchain model
`Lindsey J. Leach, Lin Wang, Michael J. Kearsey,
`and Zewei Luo
`
`IMMUNOLOGY
`
`PD-1 and CTLA-4 combination blockade expands
`infiltrating T cells and reduces regulatory T and myeloid
`cells within B16 melanoma tumors
`Michael A. Curran, Welby Montalvo, Hideo Yagita,
`and James P. Allison
`
`Dendritic cell targeted HIV gag protein vaccine provides
`help to a DNAvaccine including mobilization of
`protective CD8* T cells
`Godwin Nehinda, David Amadu, Christine Trumpfheller,
`Olga Mizenina, Klaus Uberla, and Ralph M. Steinman
`
`Mature dendritic cells use endocytic receptors to capture
`and present antigens
`Craig D. Platt, Jessica K. Ma, Cécile Chalouni, Melanie
`Ebersold, Hani Bou-Reslan, Richard A. D. Carano, Ira
`Mellman, and Lélia Delamarre
`
`TGF-f regulates T-cell neurokinin-1 receptor
`internalization and function
`Martin Beinborn, Arthur Blum, Long Hang, Tommy
`Setiawan, Jonathan C. Schroeder, Korynn Stoyanoff, John
`Leung, and Joel V. Weinstock
`
`MEDICAL SCIENCES
`
`Vaccination with partial knowledge of external
`effectiveness
`Charles F. Manski
`
`Systemic antiangiogenic activity of cationic poly-
`L-lysine dendrimer delays tumor growth
`Khuloud T. Al-Jamal, Wafa’ T. Al-Jamal, Simon Akerman,
`Jennifer E. Podesta, Agelya Yilmazer, John A. Turton,
`Alberto Bianco, Neil Vargesson, Chryso Kanthou, Alexander
`T. Florence, Gillian M. Tozer, and Kostas Kostarelos
`
`Disruption of angiogenesis and tumor growth with an
`orally active drug that stabilizes the inactive state of
`PDGFR/B-RAF
`:
`Eric A. Murphy, David J. Shields, Konstantin Stoletov, Elena
`Dneprovskaia, Michele McElroy, Joshua I. Greenberg,Jeff
`Lindquist, Lisette M. Acevedo, Sudarshan Anand, Bharat
`Kumar Majeti, Igor Tsigelny, Adrian Saldanha, Breda
`Walsh, Robert M. Hoffman, Michael Bouvet, Richard L.
`Klemke, Peter K. Vogt, Lee Arnold, Wolfgang Wrasidlo,
`and David A. Cheresh
`
`

`

`4305
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`4311
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`4317
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`4323
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`4329
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`4335
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`4341
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`4347
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`4353
`
`4359
`
`4365
`
`Islet amyloid deposition limits the viability of human
`islet grafts but not porcine islet grafts
`K. J. Potter, A. Abedini, P. Marek, A. M. Klimek,
`S. Butterworth, M. Driscoll, R. Baker, M. R. Nilsson,
`G. L. Warnock, J. Oberholzer, 8. Bertera, M. Trucco,
`G. 8. Korbutt, P. E. Fraser, D. P. Raleigh, and C. B. Verchere
`
`Activatable cell penetrating peptides linked to
`nanoparticles as dual probesforin vivo fluorescence and
`MR imaging of proteases
`Emilia S. Olson, Tao Jiang, Todd A. Aguilera, Quyen
`T. Nguyen, Lesley G. Ellies, Miriam Scadeng,
`and Roger Y. Tsien
`
`Surgery with molecular fluorescence imaging using
`activatable cell-penetrating peptides decreases residual
`cancer and improvessurvival
`Quyen T. Nguyen, Emilia $. Olson, Todd A. Aguilera, Tao
`Jiang, Miriam Scadeng, Lesley G. Ellies, and Roger Y. Tsien
`
`High-risk neuroblastoma tumors with 11q-deletion
`display a poor prognostic, chromosomeinstability
`phenotype with later onset
`Helena Carén, Hanna Kryh, Maria Nethander, Rose-Marie
`Sjéberg, Catarina Trager, Staffan Nilsson, Jonas
`Abrahamsson, Per Kogner, and Tommy Martinsson
`
`Loss of myeloid cell-derived vascular endothelial growth
`factor accelerates fibrosis
`Christian Stockmann, Yann Kerdiles, Marc Nomaksteinsky,
`Alexander Weidemann, Norihiko Takeda, Andrew Doedens,
`Antonio X. Torres-Collado, Luisa Iruela-Arispe, Victor Nizet,
`and Randall S. Johnson
`
`Neural differentiation of human induced pluripotent
`stem cells follows developmentalprinciples but with
`variable potency
`Bao-Yang Hu, Jason P. Weick, Junying Yu, Li-Xiang Ma,
`Xiao-Qing Zhang, James A. Thomson, and Su-Chun Zhang
`
`MICROBIOLOGY
`
`Only two aminoacids are essential for cytolytic toxin
`recognition of cholesterol at the membrane surface
`Allison J. Farrand, Stephanie LaChapelle, Eileen M. Hotze,
`Arthur E. Johnson, and Rodney K. Tweten
`
`Three-dimensional structure of tropism-switching
`Bordetella bacteriophage
`Wei Dai, Asher Hodes, Wong H. Hui, Mari Gingery, Jeff F.
`Miller, and Z. Hong Zhou
`
`Gallstones play a significant role in Salmonella spp.
`gallbladder colonization and carriage
`Robert W. Crawford, Roberto Rosales-Reyes, Maria de
`la Luz Ramirez-Aguilar, Oscar Chapa-Azuela, Celia
`Alpuche-Aranda, and John S. Gunn
`
`Reactogenicity of live-attenuated Vibrio cholerae
`vaccines is dependenton flagellins
`Haopeng Rui, Jennifer M. Ritchie, Roderick T. Bronson, John
`J. Mekalanos, Yuanxing Zhang, and Matthew K. Waldor
`
`In vivo actin cross-linking induced by Vibrio cholerae
`type VI secretion system is associated with intestinal
`inflammation
`Amy T. Ma and John J. Mekalanos
`
`4371
`
`4377
`
`4383
`
`4389
`
`4395
`
`4401
`
`4407
`
`4412
`
`4418
`
`4424
`
`4430
`
`4436
`
`Molecular complexity of successive bacterial epidemics
`deconvoluted by comparative pathogenomics
`Stephen B. Beres, Ronan K.Carroll, Patrick R. Shea, Izabela
`Sitkiewicz, Juan Carlos Martinez-Gutierrez, Donald E. Low,
`Allison McGeer, Barbara M.Willey, Karen Green, Gregory J.
`Tyrrell, Thomas D. Goldman, Michael Feldgarden, Bruce W.
`Birren, Yuriy Fofanov, John Boos, William D, Wheaton,
`Christiane Honisch, and James M. Musser
`
`Molecular keys of the tropism of integration of the
`cholera toxin phage
`Bhabatosh Das, Julien Bischerour, Marie-Eve Val,
`and Frangois-Xavier Barre
`=> See Commentary on page 3951
`
`The early autophagic pathwayis activated by hepatitis B
`virus and required for viral DNA replication
`DonnaSir, Yongjun Tian, Wen-ling Chen, David K. Ann,
`Tien-Sze Benedict Yen, and Jing-hsiung James Ou
`
`NEUROSCIENCE
`
`Promoting social behavior with oxytocin in high-
`functioning autism spectrum disorders
`Elissar Andari, Jean-René Duhamel, Tiziana Zalla, Evelyn
`Herbrecht, Marion Leboyer, and Angela Sirigu
`
`BDNF variant Val66Metinteracts with estrous cycle in
`the control of hippocampal function
`Joanna L. Spencer, Elizabeth M. Waters, Teresa A. Milner,
`Francis S. Lee, and Bruce S. McEwen
`
`Forebrain overexpression of CK18 leads to down-
`regulation of dopamine receptors and altered
`locomotoractivity reminiscent of ADHD
`Mingming Zhou, Heike Rebholz, Christine Brocia, JenniferL.
`Warner-Schmidt, Allen A. Fienberg, Angus C. Nairn, Paul
`Greengard, and Mare Flajolet
`
`Lower numberof cerebellar Purkinje neurons in
`psychosis is associated with reduced reelin expression
`Ekrem Maloku, Ignacio R. Covelo, Ingeborg Hanbauer,
`Alessandro Guidotti, Bashkim Kadriu, Qiaoyan Hu, John M.
`Davis, and Erminio Costa
`
`Endocytosis and clathrin-uncoating defects at synapses
`of auxilin knockout mice
`Yang-In Yim, Tao Sun, Ling-Gang Wu, Andrea Raimondi,
`Pietro De Camilli, Evan Eisenberg, and Lois E. Greene
`
`Molecular basis of odor coding in the malaria vector
`mosquito Anopheles gambiae
`Guirong Wang, Allison F. Carey, John R. Carlson,
`and Laurence J. Zwiebel
`
`Genetic approach for intracerebroventricular delivery
`Limor Regev, Eli Ezrielev, Eran Gershon, Shosh Gil,
`and Alon Chen
`
`Cortical activity during motor execution, motor imagery,
`and imagery-based online feedback
`Kai J. Miller, Gerwin Schalk, Eberhard E. Fetz, Marcel den
`Nijs, Jeffrey G. Ojemann, and Rajesh P. N. Rao
`
`Adult hippocampal neurogenesis is functionally
`important for stress-induced so