`

`FOR THE PURPOSES OF INFORMATION ONLY
`
`Codes used to identify States party to the PCT on the front pages of pamphlets publishing international
`applications under the PCT.
`
`AM
`AT
`AU
`BB
`BE
`BF
`BG
`BJ
`BR
`BY
`CA
`CF
`CG
`CH
`Cl
`CM
`CN
`cs
`CZ
`DE
`DK
`EE
`ES
`Fl
`FR
`GA
`
`Armenia
`Austria
`Austtalia
`Barbados
`Belgium
`Burkina Faso
`Bulgaria
`Benin
`Brazil
`Belarus
`Canada
`Central African Republic
`Congo
`Switzerland
`COie d'Ivoire
`Cameroon
`China
`Czechoslovakia
`Czech Republic
`Germany
`Denmark
`Estonia
`Spain
`Finland
`France
`Gabon
`
`GB
`GE
`GN
`GR
`HU
`IE
`IT
`JP
`KE
`KG
`KP
`
`KR
`KZ
`LI
`LK
`LR
`LT
`LU
`LV
`MC
`MD
`MG
`ML
`MN
`MR
`
`United Kingdom
`Georgia
`Guinea
`Greece
`Hungary
`Ireland
`Italy
`Japan
`Kenya
`Kyrgystan
`Democratic People's Republic
`of Korea
`Republic of Korea
`Kazakhstan
`Liechtenstein
`Sri Lanka
`Liberia
`Lithuania
`Luxembourg
`Latvia
`Monaco
`Republic of Moldova
`Madagascar
`Mali
`Mongolia
`Mauritania
`
`MW
`MX
`NE
`NL
`NO
`NZ
`PL
`PT
`RO
`RU
`SD
`SE
`SG
`SI
`SK
`SN
`sz
`TD
`TG
`TJ
`TT
`UA
`UG
`us
`uz
`VN
`
`Malawi
`Mexico
`Niger
`Netherlands
`Norway
`New Zealand
`Poland
`Portugal
`Romania
`Russian Federation
`Sudan
`Sweden
`Singapore
`Slovenia
`Slovakia
`Senegal
`Swaziland
`Chad
`Togo
`Tajikistan
`Trinidad and Tobago
`Ukraine
`Uganda
`United States of America
`Uzbekistan
`Viet Nam
`
`Geneoscopy Exhibit 1009, Page 2
`
`

`

`WO 97/25925
`
`PCT/IL97/00017
`
`- 1 -
`
`COLLECTION AND TRANSPORTATION OF
`A PASTY MATERIAL SAMPLE
`
`FIELD OF THE INVENTION
`
`The present invention concerns a system for the collection and
`
`transportation of a pasty material sample, for example of stool, which is to
`
`be distributed in a transport and/or suspension medium.
`
`5
`
`BACKGROUND OF THE INVENTION
`Collection and transportation of a pasty material, such a stool,
`
`food samples, soil samples and the like for the purpose of laboratory
`
`manipulation such as detection of microorganism being bacteria or parasites,
`
`10
`
`detection of cryptic blood, preparation of a biochemical profile, etc., is an
`
`essential component of modern medicine, health care and environmental
`
`management.
`
`Often, when the pasty material is transported to the laboratory
`
`without a preservation medium, by the time it reaches a laboratory no viable
`
`15 micro-organisms can be detected, and the result of the laboratory tests are
`
`thus distorted.
`
`In order to overcome this problem, various devices and systems
`
`for the collection and transportation of pasty material have been developed,
`
`in which the pasty material is distributed in a medium capable of maintain-
`
`20
`
`ing viable microorganisms. Usually, such devices comprise a container
`
`holding the medium, and a sampler capable of picking up a small portion of
`
`the pasty material and placing it within said container.
`
`Geneoscopy Exhibit 1009, Page 3
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`-2-
`
`US 5,149,506 discloses a device for collection and transportation
`
`of a stool sample which is composed of a container with a lid having a
`
`spoon secured to the underside of the lid, the container being filled with a
`
`liquid capable of maintaining microorganisms in a viable form.
`
`5
`
`US 4,559,839 discloses a stool collection and concentration
`
`receiver comprising a container holding a medium and including within it
`
`a collecting-filtering device comprising a stick for picking up the stool
`
`sample and sieve through which the diluted stool is filtered.
`
`US 4,678,559 discloses a sampling vessel for pasty sample
`
`10 material comprising a sample-taking cup fitted on the lid of a container and
`
`facing towards the container's bottom.
`
`In the above three patents the sampling member, used to pick the
`
`sample of the pasty material, is held a priori within the container holding
`
`also the preservation medium. This feature has the following problems:
`
`15
`
`in order to sample the pasty material the container holding both
`
`the medium and the sampling member has to be opened, thus increasing the
`
`chances of contamination of the steri1e medium by ambient atmosphere, or
`
`by the hands of the user and increases the possibility of spillage due to
`
`mishandling;
`
`20
`
`once the sampling member is taken out of the medium filled
`
`container it may drip the medium on to its surrounding, and where the
`
`medium contains harmful ingredients, e.g. formaldehyde or mercury which
`are present in some preservation media, this may cause some damage if it
`
`comes into contact with the user's skin or eyes;
`
`25
`
`the wet sampling member, once coming into contact with the
`
`pasty material sample, adds to the sample also a certain amount of the
`
`transport or suspension medium itself. This may be problematic if another
`
`sample of the pasty material is to be transferred into another container
`
`holding a different medium, since the second sample may already be
`
`30
`
`contaminated by the first medium.
`
`A stool sample is typically subjected to two different tests one
`
`being a bacteriological test and the other a parasitological test. The medium
`
`Geneoscopy Exhibit 1009, Page 4
`
`

`

`WO 97/25925
`
`PCT/IL97/00017
`
`-3-
`
`required to maintain viable bacteria and the medium required to maintain
`
`viab]e parasites are not only different but are mutua1ly exclusive, i.e. one
`
`type of medium damages the other type of microorganism. Thus, in the case
`
`of a pasty material which is to be sampled for the purpose of two or more
`
`5
`
`different laboratory assay, such as stool, it would be preferable to provide
`
`a system for co11ection and transportation of pasty material which comprises
`
`two or more separate containers each one holding a different transport or
`
`suspension medium.
`
`Final1y, the above-mentioned prior art devices for collection and
`
`10
`
`transportation of stool, do not address the problem of obtaining the original
`
`stool sample in a convenient manner which enab]es easy access to the user
`
`and the prior art tends to leave the solution to the problem to the skills of
`
`each user.
`
`The present invention intends to provide an answer to some of the
`
`15
`
`above-noted problems.
`
`GENERAL DESCRIPTION OF THE INVENTION
`The present invention provides a system for co11ecting, storing
`
`and transporting of specimens of a pasty material, comprising:
`
`20
`
`at least one container holding a preservation medium for preserving a
`
`chemical entity or living matter to be assayed in the specimen, the container
`
`being sealed by a pierceable membrane and having a closure arrangement
`
`for sealing the container after the membrane is pierced; and
`
`a sampling device having a hand1e and at least one elongated specimen
`
`25
`
`collecting member detachably attached thereto, the co11ecting member being
`
`adapted to be received within the container and having a pasty material
`
`retaining portion and a piercing tip for piercing the membrane at a
`
`lowermost end thereof remote from said handle, for piercing said film.
`
`The system of the present invention is suitable for collecting,
`
`30
`
`storing and transporting of any pasty material, for example, stools, food
`
`samples, e.g. soft cheese, yogurt, various spreads; soil samples, e.g. mud
`
`samples; and many others. With appropriate preservation media, the
`
`Geneoscopy Exhibit 1009, Page 5
`
`

`

`W097/2S925
`
`PCT/IL97/00017
`
`-4-
`
`samples may be stored for a lengthy period of time prior to assaying for the
`
`chemical entity or living matter. The composition of the medium depends
`
`on the type of entity which should be preserved and subsequently assayed:
`
`for example, if the entity is a chemical substance, the medium will have a
`
`5
`
`composition which ensure that the substance is preserved in a manner to
`
`avoid its deterioration; if the assayed entity is microorganism or any other
`
`living matter, the medium will be designed so as to maintain such microor(cid:173)
`
`ganisms or other living matter in a viable condition. A system for
`
`collecting, storing and transporting specimens to subsequent assays for living
`
`10 matter, e.g. microorganisms, yeasts or parasites thereon, is a preferred
`
`embodiment of the invention.
`
`In accordance with a particularly preferred
`
`embodiment, the pasty material is stool.
`
`At times a variety of different entities have to be assayed in the
`
`pasty material. This is the case, for example, in stool, where it is generally
`
`15
`
`desired to assay both bacteria and parasites, which as noted above, require
`
`different media. A system for assaying a plurality of entities, which require
`
`different media, comprises at least two containers, each holding a different
`
`preservation medium, each suitable for different entities. The containers in
`
`such a system may be permanently attached to one another; or alternatively,
`
`20
`
`the attachment of the two containers to one another being in a detachable
`fashion to allow detachment when the containers with the sample reaches the
`laboratory.
`
`The closure arrangement is typically a rigid lid member attached
`
`to the container through a flexible linker.
`
`25
`
`The system further comprises a sampling device which is an
`
`element distinct and separate from the ·container. The provision of the
`
`container and a separate sampling device ensures that until the pasty material
`
`sample is introduced into the container, the medium therein is kept totally
`
`sterile. As already noted above, in prior art devices, where a sampling
`device was stored within the container, it was necessary to open the
`
`30
`
`container prior to sampling, with an inevitable loss of sterility.
`
`Geneoscopy Exhibit 1009, Page 6
`
`

`

`W097/25925
`
`PCT/IL97 /00017
`
`-5-
`
`The sampling device comprises a handle which is detachably
`
`connected to the at least one collecting member. The detachable connection
`
`can be by a breakable portion, by a fastener capable of holding or releasing
`
`an attachment element in the collecting member, etc. The at least one
`
`5
`
`collecting member is adapted to be received within corresponding at least
`(It will be appreciated, that the number of collecting
`
`one container.
`
`members will typically correspond to the number of containers, and where
`the containers are held together, the spacing between the collecting members
`
`will be made to correspond to the distance between the container such that
`
`10
`
`all collecting members may be inserted simultaneously to the respective
`
`containers).
`
`Each collecting member has a piercing tip for piercing the
`
`container's pierceable membrane and has a pasty material retaining portion.
`
`Once the membrane is pierced by the piercing tip, the collecting member is
`
`15
`
`pushed down until the material retaining portion is accommodated within the
`container and embedded in the medium. Then, the handle is detached from
`
`the collecting member. As will be appreciated, there are a number of
`
`different constructions which have the capability of retaining a specimen of
`
`the pasty material: for example, a rough surface having multiple depressions
`
`20
`
`and/or protrusions; a helical structure; a ladder-like shaped structure having
`
`straight, curved or V-shaped ribs; a structure comprising a planar stem with
`
`protrusions, which may have the form of straight, curved or V-shaped ribs,
`
`or which may comprise a plurality of bulges, etc.
`In order to ensure that the pasty material will be retained on the
`retaining portion and will not be smeared on the membrane, it is preferable
`
`25
`
`that the pasty material retaining portion has the widest cross-section at the
`
`lowermost part, near the piercing tip. This will ensure that the hole in the
`
`membrane which will be made by the piercing tip, will be sufficiently large
`
`to ensure free passage of the remaining portions of the collecting member.
`
`30
`
`In accordance with an embodiment of the invention, the pasty material
`
`retaining portion is defined by two lateral side walls which are wider than
`
`the pasty material retaining portion. Thus during insertion, only these side
`
`Geneoscopy Exhibit 1009, Page 7
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`-6-
`
`walls come into contact with the membrane, whereby the majority of the
`
`specimen of the pasty material does not come into contact with the
`
`membrane.
`
`In accordance with a preferred embodiment of the invention, the
`
`5
`
`sampling device comprises an integral disc with its surface being essentially
`
`perpendicular to the longitudinal axis of the collecting member. The shape
`
`of the disc is such that once the collecting member is introduced into the
`
`container, the disc is snugly retained within the inner walls of the container
`
`thus stabilizing the position of the co11ecting member within the container.
`
`10
`
`The disc preferably defines an opening which allows the insertion of a
`
`laboratory sampling device, e.g. a pipette, a sampling needle, etc, for
`
`withdrawing a portion of the specimen, this without a need to remove the
`
`collecting member with the integral disc.
`
`As can be seen, the system of the invention minimize possible
`contact between a sample and a laboratory technician, which is especially
`
`15
`
`important in cases where the sample may contain hazardous materials or
`
`microorganisms.
`
`In accordance with a preferred embodiment of the invention, as
`
`already noted above, the pasty material is stool.
`
`ln accordance with this
`
`20
`
`embodiment, the system may comprise a stool collecting device, which has
`
`a collecting member for collecting an excreted stool sample and attachment
`
`members for attachment to a toilet seat. The stool collecting device also
`
`forms an independent aspect of the invention. The device is typically made
`
`of a sheet, e.g. a paper sheet, with the collecting portion and the attachment
`25 member being integral, i.e. made of the same sheet. The attachment
`
`member may be a sheet portion adapted for wrapping around a toilet seat
`
`and are then retained by virtue of being sandwiched between the toilet seat
`
`and the upper edges of the toilet bowl. Alternatively, the attachment
`
`member may comprise adhesive patches on a bottom face of the attachment
`
`30 member for adherence thercthrough to the toilet seat. The adhesive patches
`
`are a priori protected with the protection being used prior to use and
`
`attachment thereof to the toilet scat.
`
`Geneoscopy Exhibit 1009, Page 8
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`-7-
`
`In accordance with an embodiment of the invention, the stool
`
`collecting member is a sheet portion suspended between the attachment
`
`members. Alternatively, the stool collecting member may have the form of
`
`a sack for collecting excreted stool sample. Such a sack may be provided
`
`5
`
`with openings at its bottom to allow a drainage of excreted fluid while
`
`retaining the stool.
`
`The stool collecting device is preferably made of a flushable
`
`material, e.g. thin paper, and after use may be dropped into the toilet bowl
`
`to be flushed thereby.
`
`10
`
`The invention will now be further illustrated by the following
`
`description of a specific embodiment and by the annexed drawings. The
`
`illustrated embodiment concerns a system for collecting, storing and
`
`transporting stool samples. However, as will no doubt be appreciated by the
`
`artisan, this is an example only and the invention pertains also to systems for
`
`15
`
`collecting specimens of pasty material other than a stool.
`
`BRIEF DESCRIPTION OF THE ORA WINGS
`Fig. 1 is an exploded view of a system of the invention comprising two
`
`containers and a sampling device with two corresponding collecting
`
`20 members;
`Fig. 2 shows the system, with the containers being assembled on a base
`
`and with the collecting member holding a stool sample;
`Fig. 3 shows the system after combining the sampling device with the
`
`containers with the collecting member being inserted in the container;
`Fig. 4 shows the system after separating between the handle and the
`
`25
`
`collecting members;
`Fig. 5 shows the system after closing of the lid, ready for transporta(cid:173)
`
`tion into the laboratory;
`Fig. 6 shows a stool collecting device in accordance with the invention;
`
`30
`
`Figs. 7 and 8 show stool collecting devices in accordance with other
`
`embodiments of the invention, attached to a toilet seat.
`
`Geneoscopy Exhibit 1009, Page 9
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`-8-
`
`DESCRIPTION OF SPECIFIC EMBODIMENTS
`Reference is first being made to Fig. 1, which is an exploded
`
`view showing the various components of the system, generally designat(cid:173)
`ed 10. The system 10 comprises two attached containers 12 and 12', a base
`
`5 member 14 with two receptacles 16 and 16' adapted to receive the bottom
`ends 18 and 18' of containers 12 and 12'; the system further comprises a
`sampling device 20 having a handle 22 and two collecting members 24
`and 24'.
`
`Containers 12 and 12' hold respective media 26 and 26', which
`
`10 may both be the same, but arc typically different, e.g. one being a media for
`
`preserving bacteria and the other for parasites. Media 26 and 26' are
`
`typically semi-solid media, e.g. agar-based, but may also be a lipid, e.g. a
`culture media. Media 26 and 26' are contained in a portion of the
`containers sealed by pierceable membranes 28 and 28', the membranes
`
`15
`
`being made of aluminum foil, a laminate of an aluminum foil and a plastic,
`(e.g. polyethylene) film, etc. Containers 12 and 12' are provided with
`
`20
`
`25
`
`respective lids 30 and 30' which are linked to the containers by means of
`linkers 32 and 32'. Sampling device 20 has integral disc members 34 and
`34' at the upper end of specimen collecting members 24 and 24'. Disc 34
`and 34' have each respective openings 35 and 35', the functions of which
`
`will be explained further below. Handle 22 is connected to disc mem(cid:173)
`
`bers 34 and 34' by means of breakable neck portions 36 and 36' by small
`
`lateral respective movements of the handle and the collecting members
`connecting necks 36 and 36' break whereby handle 22 and collecting
`members 24 and 24' are separated.
`Collecting members 24 and 24' are elongated and have each a
`
`piercing tip 38 and 38' at its bottom end adapted for piercing membranes 28
`and 28'. Collecting members 24 and 24' have two lateral walls 40 and 40'
`
`30
`
`which define the stool retaining portion consisting also of planar mem-
`bers 42 and 42' disposed within the lateral walls and carrying a plurality of
`V-shaped protrusions 44 and 44'. As can be seen, the collecting members
`
`Geneoscopy Exhibit 1009, Page 10
`
`

`

`W097/25925
`
`PCT/IL97/000I7
`
`-9-
`
`have the largest cross-section at a portion adjacent piercing tips 38 and 38'
`
`thus the hole which is created in the membranes 28 and 28' allows easy
`
`passage therethrough for the remaining portions of the collecting members.
`Furthermore, lateral walls 40 and 40' ensure that the stool specimen held
`
`5
`
`on planar members 42 and 42' is not removed by the membranes 28
`and 28' during passage of col1ecting members 24 and 24'.
`
`In order to collect specimens of pasty material, collecting
`
`members 24 and 24' are inserted into a sample of the pasty material, e.g.
`
`stool, and thereby specimens are retained on collecting members 24 and 24'.
`Sampling device 20 with stool specimens 50 and 50' retained on col1ecting
`
`10
`
`members 24 and 24' is seen in Fig. 2. Also seen in this figure are
`
`containers 12 and 12' assembled on base member 14.
`
`After collection of the specimens, the sampling device and the
`containers are combined by first pressing piercing tips 38 and 38' against
`
`15
`
`membranes 28 and 28' and then pushing the collecting members until they
`are accommodated within containers 12 and 12' with the collecting
`
`members being embedded within the medium containing the containers.
`Fig. 3 shows the sampling device 20 and containers 12 and 12' immediately
`after combining the two. As can be seen, the size of disc members 34
`and 34' are such that they are accommodated snugly within the inner walls
`
`20
`
`of the container stabilizing the collecting member in position.
`
`At a next step shown in Fig. 4, the handle 22 is moved naturally
`
`thus breaking necks 36 and 36' leaving the collecting members within
`containers 12 and 12'. At a next step shown in Fig. 5, lids 30 and 30' are
`used to close containers 12 and 12' and at this state the containers are
`
`shipped to the laboratory. In the laboratory, the lids are opened to a state
`
`similar to that shown in Fig. 4, and then a sampling device, e.g. a pipette,
`a bacteriologic needle, etc., is inserted through openings 35 and 35'. Thus,
`
`sampling of the specimen for laboratory testing does not require removal of
`
`30
`
`the collecting member, as in the case of prior art devices.
`
`Geneoscopy Exhibit 1009, Page 11
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`- 10 -
`
`A stool collecting device in accordance with an embodiment of
`the invention is shown in Fig. 6. The device, generally designated 60 is
`
`made of a sheet, e.g. paper, particularly thin paper which is flushable in a
`
`toilet. The device has a central collecting member, which is a portion of a
`sheet having the form of a sack, and has two attachment members 64 and 66
`
`5
`
`which are of a length such that their ends will reach two opposite sides of
`a toilet seat. The attachment members 64 and 66 have two adhesive
`
`patches 68 and 70, on bottom faces of the device. Adhesive patches 68
`
`and 70 are a priori covered by a protective cover (now shown) and prior to
`
`10
`
`use, the cover is removed and then these patches can adhere to the toilet
`
`seat. The device is fixed such that stool excreted by a person sitting on the
`
`toilet, falls into a sack-like collecting member 62 for later sampling by the
`
`sampling device. As can further be seen in Fig. 6, collecting member has
`
`at its bottom four openings 72 which arc intended to allow a discharge of
`
`15
`
`fluids which may be excreted together with the stool.
`
`Two other embodiments of a stool collecting device are shown in
`Figs. 7 and 8, fixed to a toilet seat. The stool collecting device 80 shown
`
`in Fig. 7, is in principle similar to device 60 shown in Fig. 6 in that it
`
`comprises a central sack-like portion 82 and peripheral attachment flaps 84
`and 86. Device 80 is fixed to a toilet seat 88 by means of adhesive patches,
`
`20
`
`similarly as in the case of device 60 in Fig. 6.
`Device 90 shown
`
`in Fig. 8, comprises a stool co11ecting
`
`portion 92 which is a sheet, e.g. made of paper, suspended between two
`
`attachment members 94 and 96 which are two flaps which are wrapped
`
`25
`
`around two opposite sides of the toilet seat 98, and are fixed by virtue of
`
`being clamped between the toilet scat and the underlying toilet bowl (not
`
`In addition a device of this embodiment may also comprise
`shown).
`adhesive patches at the bottom face members of 94 and 96 to aid in fixing
`
`them to the toilet seat.
`
`30
`
`Having now finalized the description of the specific embodiment,
`
`the artisan will no doubt appreciate that the above specific embodiment is
`
`Geneoscopy Exhibit 1009, Page 12
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`- 11 -
`
`an example only and a myriad of other designs of the container and the
`
`sample device as well as the stool collecting device are possible, all being
`
`within the scope of the invention as defined in the appended claims.
`
`Geneoscopy Exhibit 1009, Page 13
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`- 12 -
`
`CLAIMS:
`
`1.
`
`A system for coJlecting, storing and transporting of specimens of
`
`a pasty material, comprising:
`
`5
`
`at least one container holding a preservation medium for preserving a
`
`chemical entity or living matter to be assayed in the specimen, the container
`
`being sealed by a pierceable membrane and having a closure arrangement
`
`for sealing the container after the membrane is pierced; and
`
`a sampling device having a handle and at least one elongated specimen
`
`10
`
`collecting member detachably attached thereto, the collecting member being
`
`adapted to be received within the container and having a pasty material
`
`retaining portion and a piercing tip for piercing the membrane at a
`
`lowermost end thereof remote from said handle, for piercing said film.
`2.
`
`A system according to Claim 1, wherein the medium is of a kind
`
`15
`
`which maintains living matter in a viable condition.
`3.
`
`A system according to Claim 2, wherein the pasty material is
`
`stool.
`4.
`
`A system according to Claim 1, comprising two containers, one
`
`holding a medium for bacteria and another for holding a medium for
`
`20
`
`parasites.
`5.
`
`A system according to Claim 4, wherein the two containers are
`
`attached to one another.
`6.
`
`A system according to Claim 4 or 5, wherein the sampling device
`
`comprises two specimen collecting members.
`
`,;(cid:173)
`.... )
`
`7 .
`
`A system according to any one of the preceding claims, wherein
`
`said collecting member has a piercing tip for piercing the containers'
`
`pierceable membrane and has a pasty material retaining portion.
`
`8.
`
`A system according to Claim 7, wherein the pasty material
`
`retaining portion has the widest cross-section at a lowermost part thereof,
`
`30
`
`near the piercing tip.
`
`Geneoscopy Exhibit 1009, Page 14
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`- 13 -
`
`9.
`
`A system according to any one of the preceding claims, wherein
`
`the sampling device comprises an integral disc in an upper end of the
`
`collecting member, with its surface being essentially perpendicular to the
`
`longitudinal axis of the collecting member.
`
`5
`
`10.
`
`A system according to Claim 9, wherein the shape of the disc is
`
`such that once the collecting member is introduced into the container, the
`
`disc is snugly retained within the inner wal1s of the container.
`
`11.
`
`A system according to Claim 10, wherein the disc defines an
`
`opening which once the collecting member is placed within the container,
`
`10
`
`allows insertion of a laboratory sampling device into the medium, without
`
`a need to remove the collecting member.
`12.
`
`A stool collecting device which has a collecting member for
`
`col1ecting an excreted stool sample and attachment members for attachment
`
`to a toilet seat.
`13.
`
`A device according to Claim 11, made of a sheet with a stool
`
`15
`
`collecting portion and integral flats for attachment to a toilet seat.
`14.
`
`A device according to Claim 12, comprising adhesive patches for
`
`fixing the device into a toilet seat.
`15.
`
`A system according to any one of Claims 1-10, comprising a
`
`20
`
`stool collecting device according to any one of Claims 11-13.
`
`Geneoscopy Exhibit 1009, Page 15
`
`

`

`W097!2S92S
`
`PC'f flL97/00017
`
`117
`
`20
`
`22
`
`38'
`
`32'
`
`28'
`
`30'
`
`14
`
`Fig. 1
`
`Geneoscopy Exhibit 1009, Page 16
`
`

`

`WO 97/25925
`
`PCT/IL97/00017
`
`2/7
`
`20
`
`~
`
`38
`
`Fig.2
`
`Geneoscopy Exhibit 1009, Page 17
`
`

`

`wo 97125925
`
`3/7
`
`PCTID.,97100017
`
`22
`
`Fig.3
`
`Geneoscopy Exhibit 1009, Page 18
`
`

`

`wo 91125925
`
`4/7
`
`PCTfIL97!00tJ17
`
`Fig.4
`
`Geneoscopy Exhibit 1009, Page 19
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`5/7
`
`30'
`
`12
`
`Fig.5
`
`Geneoscopy Exhibit 1009, Page 20
`
`

`

`W097/25925
`
`PCT/IL97/00017
`
`6/7
`
`Geneoscopy Exhibit 1009, Page 21
`
`

`

`