JUDITH KORNER, M.D., Ph.D.
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`February 13, 2024
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`WORK EXPERIENCE
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`Academic:
`07/1996 - 06/1997
`12/1999 - 11/2010
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`Instructor (Chief Resident) in Clinical Medicine, Columbia University
`Assistant Professor of Clinical Medicine, Columbia University College of
`Physicians & Surgeons
`Associate Professor of Medicine at Columbia University Medical Center
`Professor of Medicine at Columbia University Medical Center
`
`Attending Physician (Chief Resident), Columbia Presbyterian Medical
`Center
`Attending Physician, New York Presbyterian/Columbia University Medical
`Center
`Director, Metabolic and Weight Control Center, Columbia University
`Medical Center; Ranked among top 15 Medical Weight Loss Centers in US
`by Health Magazine (2014)
`
`11/2010 - 03/2015
`03/2015 - present
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`Hospital:
`07/1996 - 06/1997
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`12/1999 - present
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`07/2006 - present
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`POSTDOCTORAL TRAINING
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`07/1997 - 11/1999 Post-Doctoral Clinical Fellow, Endocrinology, Columbia Presbyterian
`Medical Center
`07/1996 - 06/1997 Chief Resident and Clinical Assistant Physician, Internal Medicine,
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`Columbia Presbyterian Medical Center
`07/1993 - 06/1996 Resident, Internal Medicine, Columbia Presbyterian Medical Center
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`EDUCATION
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`1993
`1992
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`M.D., College of Physicians & Surgeons, Columbia University
`Ph.D., Biochemistry and Molecular Biophysics, Columbia University
`Thesis Title: Prohormone Processing: Characterization of the Cleavage
`Signals and Cleavage Enzymes. University Microfilms International, Ann
`Arbor, MI
`Sponsor: Richard Axel, M.D.
`B.A., Barnard College, Columbia University
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`1979
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`LICENSURE and BOARD CERTIFICATION
`11/30/2023
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`New York State License 204016-1
`1996
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`Diplomate of American Board of Internal Medicine
`1999, 2011
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`Diplomate of American Board of Endocrinology
`2014
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`Diplomate of American Board of Obesity Medicine
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0001
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`HONORS AND AWARDS
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`1979
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`1979
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`1979
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`1990
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`1993
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`1998
`1998 - 2000
`2002 - 2005
`2010 - 2011
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`Magna Cum Laude, Barnard College, Columbia University
`Phi Beta Kappa, Barnard College, Columbia University
`Dean's Prize, Barnard College, Columbia University
`Dean's Day Medical Student Research Award, College of
`Physicians & Surgeons, Columbia University
`Upjohn Research Award
`
`Endocrine Fellows Foundation Grant
`NIH Feasibility Award, New York Obesity Research Center
`Florence Irving Assistant Professor; Irving Scholar Award
`Diabetes and Endocrinology Research Center (DERC) Pilot and
`Feasibility Award
`Herbert Pardes Fellow Award
`
`
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`2010 - 2012
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`PROFESSIONAL ORGANIZATIONS, SOCIETIES and SERVICE
`
`Memberships:
`2009 - 2010
`Present
`Present
`Present
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`
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`Committee Member, Certification of Obesity Medicine examination
`Member: Endocrine Society, American Diabetes Association
`Fellow: The Obesity Society
`Senior Scholar: Healthcare Innovation Technology Lab, Columbia
`University Medical Center
`10/2014 – 12/2016 Board of Directors: American Board of Obesity Medicine (ABOM)
`01/2017 – 12/2021 Vice Chair: ABOM Board of Directors
`2019 – present
`Chair: Journal Article Review Recertification Pathway, ABOM
`01/2022 – present
`Chair: ABOM Board of Directors
`
`Consultative:
`2010 - 2012
`2011
`2011
`2012, 2021
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`Scientific Advisory Board: Nutrisystem
`Scientific Advisory Board: Johnson & Johnson/ Ethicon
`Consultant: Unigene
`Consultant: Federal Trade Commission; Office of Professional
`Misconduct
`Consultant: Digma Medical
`Expert Witness: Servier Labs
`Consultant: Applied Biosystems
`Scientific Advisory Board: GI Dynamics
`Chief Medical Advisor: Found Health
`Scientific Advisory Board: GilaTherapeutics
`External Advisory Board: U54 (REVEAL: Research Evaluating Vagal
`Excitation and Anatomical Linkages or VESPA)
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`2016 – 2020
`2019, 2023
`2019 – 2020
`2019 – present
`2019 – present
`2021 – present
`2022
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`Editorial:
`Ad Hoc Reviewer
`
`Amer J Clin Nutrition; Amer J Physiology; Clin Endocrinology; Diabetes;
`Diabetes, Obesity, Metab; Endocrinology; Int J Obesity; J Clin Endo
`Metab; J Clin Investigation; Metabolism; Obesity; Nutrition; SOARD
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`NIH Study Sections:
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`2
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0002
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`10/05; 2/08; 6/09
`04/2008
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`02/2009
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`02/2010
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`07/2011
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`04/2012
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`04/2013
`07/2013
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`06/2014 - 2018
`04/2021
`08/2023
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`Ad Hoc Reviewer: Clinical and Integrative Diabetes and Obesity
`Bariatric Surgery Ancillary Studies
`Metabolic Endocrinology
`Special Emphasis Panel, RFA-DK-09-012, Pilot Studies in T2DM, CV
`Risk Factors or in Cardiovascular, Lung, or Sleep Diseases after Bariatric
`Surgery
`Special Emphasis Panel, EMNR K 80: Translational Research in
`Diabetes, Obesity and Endocrinology
`Special Emphasis Panel, PAR-11-21: Collaborative Interdisciplinary
`Team Science in NIDDK Research Areas
`EMNR K80 Member Conflict applications
`NIH EMNR K80 Translational Research in Diabetes, Obesity and
`Endocrinology
`Member, Clinical and Integrative Diabetes and Obesity study section
`DP1Catalyst Award, NIDDK
`Reviewer: Diabetes in America Compendium: Obesity Management for
`the Treatment of Type 2 Diabetes Chapter
`
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`DEPARTMENT and UNIVERSITY COMMITTEES
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`1996 - 2008
`2007 - 2010
`2008 - present
`2012 - present
`2012 - present
`2015 - present
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`2015 - present
`2018 - 2019
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`2023 - present
`2023 - present
`present
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`present
`present
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`Internal Medicine Residency Selection Committee
`Scientific Advisory Committee, Center for Translational Research
`Clinical Trials Advisory Committee
`Clinical/Epidemiological Research Committee
`DSMB – FDA study on teriparatide for idiopathic osteoporosis (PI: Shane)
`Director, Pilot & Feasibility Award Program, NY Nutrition Obesity
`Research Center
`Promotions Committee, Dept of Medicine
`Endocrinology, Diabetes and Metabolism Faculty Search Committee
`DSMB - Central Mediation of GH Effects in Humans (PI: Freda)
`DSMB – Doxazosin and Insulin Sensitivity (PI: Cook)
`Member: NY Obesity Nutrition Research Center
`Member: Diabetes and Endocrinology Research Center
`Training Grants: Endocrinology; Pediatric Endocrinology; Obesity;
`Gastroenterology
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`FELLOWSHIP and GRANT SUPPPORT
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`Past
`1998
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`08/1998 - 07/2000
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`2002
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`Leptin and the Melanocortin System in Rodent Models
`Role: Principal Investigator
`Endocrine Fellows Foundation Grant; Endocrine Society
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`Analysis of the Roles of POMC and AGRP in Obesity
`Role: Principal Investigator
`New York Obesity Research Center
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`Effectiveness of Cabergoline, a New Long-Acting Dopamine Receptor
`Agonist, in Weight Loss: A Randomized Double-Blind Placebo Controlled
`Pilot Study
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`3
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0003
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`7/2002 - 6/2005
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`04/2001 - 03/2006
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`Role: Principal Investigator
`Office of Clinical Trials Pilot Study Award, Columbia University Medical
`Center
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`Florence and Herbert Irving Clinical Research Career Award
`Study of the melanocortin and dopamine pathways in obese humans.
`Effects of bariatric surgery on gastrointestinal peptides involved in energy
`homeostasis.
`Role: Principal Investigator
`Florence and Herbert Irving Scholarship
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`K08 DK59316
`Leptin and Neuroendocrine Gene Regulation in Obesity
`Role: Principal Investigator
`NIH/NIDDK
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`04/2004 - 03/2006 RO3 DK67433
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`Leptin and Neuroendocrine Gene Regulation in Obesity
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`Role: Principal Investigator
`NIH/NIDDK
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`09/2007 - 08/2009 R21 DK074503
`The Development of an Eating Laboratory for Overweight Adolescents
`Role: Co-Investigator
`PI: Timothy Walsh (NYS Psychiatric Institute)
`NIH/NIDDK
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`01/20/10 -12/31/10 RO1 DK072011-05S1
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`Metabolic Effects of Bariatric Surgery and Gastric Stimulation
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`Role: Principal Investigator
`NIH/NIDDK
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`04/2008 - 03/2011 R21 DK081050
`Effects of Leptin on Body Weight and Neuroendocrine Axes after Gastric
`Bypass
`Role: Principal Investigator
`NIH/NIDDK
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`Analysis of Peptides and Metabolites after Weight Loss in Humans with
`and without Type 2 Diabetes
`Role: Principal Investigator
`Sponsor: NGM Biopharmaceuticals
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`12/2009 - 12/2011
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`02/2010 - 01/2012 Diabetes and Endocrinology Research Center (DERC) Pilot and
`Feasibility Award (P30 DK063608-08; Accili, Lead PI)
`Role: Principal Investigator
`Sponsor: NIH
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`07/2011 - 06/2013 R21 CA155973
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`Feasibility of a weight loss intervention among female cancer survivors in
`SWOG
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`4
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0004
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`06/2008 -11/2013
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`02/2014 - 01/2015
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`6/2008 - 12/2017
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`4/2015 – 3/2020
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`9/2011 - 7/2020
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`Role: Co-Investigator
`PI: Greenlee
`Sponsor: NIH/NCI
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`The Quantification of Ingestive Behavior
`Role: Advisor
`PI: Leibel
`Sponsor: AstraZeneca
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`Prevention and treatment of obesity and diabetes using injectable brown
`adipose microtissues
`Role: Co-Principal Investigator
`Sponsor: Coulter-Columbia Translational Research Partnership
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`Diabetes Surgery Study: Effectiveness and Mechanism Trial of
`Roux-en-Y Gastric Bypass Surgery vs Intensive Medical Management for
`Type 2 Diabetes
`Role: Principal Investigator
`Sponsor: Covidien/Medtronic
`
`RO1
`Role of dopamine in metabolic surgery for T2DM
`Role: Co-Investigator
`PI: Harris
`Sponsor: NIH/NIDDK
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`RO1 DK093920
`CSF Neuropeptide, Hormonal and Metabolomic Analysis in Human
`Energy Balance
`Role: Co-Investigator
`PI: Wardlaw
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`Sponsor: NIH/NIDDK
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`Present
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`3/2-2023 – 12/2027 RO1 DK132527
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`Association of Genetic Variation Near the Dopamine D2 Receptor Gene
`and Other Polymorphisms that Modulate Dopaminergic and Opioid
`Signaling on the Weight Loss Response to Naltrexone/Bupropion.
`Role: PI
`Sponsor: NIH/NIDDK
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`8/2020 – 8/2025
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`9/2005 - 6/2024
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`RO1 DK124465
`CSF Biomarkers of Weight Loss after Bariatric Surgery
`Role: Co-PI
`NIH/NIDDK
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`RO1 DK072011
`Metabolic and Endocrine Effects of Bariatric Surgery
`Role: Principal Investigator
`NIH/NIDDK
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`5
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0005
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`4//2016 – 3/2026
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`P30 DK026687-36
`NY Obesity Nutrition Research Program
`Role: Core PI, Pilot and Feasibility Program
`PI: Rudolph Leibel
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`NIH/NIDDK
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`TEACHING EXPERIENCE and RESPONSIBILITIES
`Specific Courses:
`2009 – 2023
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`Annual Update and Intensive Review of Internal Medicine, Obesity
`Update; Columbia University
`Graduate Course in Physiology, Obesity Therapies and the Effect of
`Weight Loss; Columbia University
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`2012 - 2023
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`General Teaching Activities:
`1996, 2000 - 12
`Ward Attending, Internal Medicine
`2000 - present
`Ward Attending, Endocrinology Consult Service
`2003;2006;2013-23 Third Year Medicine Clerkship Preceptor
`
`Master’s Theses Trainees:
`09/2007 - 07/2008 Nailah Adams, Institute of Human Nutrition
`Ellen McCormick, Institute of Human Nutrition
`09/2008 - 07/2009
`11/2009 - 07/2010 Genevieve Hayek, Institute of Human Nutrition
`11/2009 - 07/2010
`Kyla Marie Lara, Institute of Human Nutrition
`11/2010 - 08/2011 Raza Ashraf, Institute of Human Nutrition
`11/2010 - 08/2011 Raashi Mamtani, Institute of Human Nutrition
`11/2012 - 07/2013
`Alina Tsouristakis, Institute of Human Nutrition
`11/2013 - 09/2014 Mary Shen, Mia Syn, Amanda Winn, Institute of Human Nutrition
`11/2016 – 09/2017
`Lilli Mohebbi, Institute of Human Nutrition
`11/2022 – 09/2023
`Ilana Moffet, Institute of Human Nutrition
`11/2023 -
`Dominic Aillaf, Institute of Human Nutrition
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`Ph.D. Advisory and Defense Committees:
`09/2010
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`Thesis Defense Committee: Chutima Talchai (Accili lab)
`2012 - 09/2014
`Thesis Advisory and Defense Committee: Joshua Cook (Accili lab)
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`Other Trainee Advisory Roles:
`2002 - present
`Medical Students: Jacqueline Lonier, Rosemary Ku
`Master of Nursing Student: Lorraine Olivera-Rivera
`Medicine Residents: Janet Lo, Rocio Salas, Yair Lev, Suneel Kamath
`Elizabeth Kunreuther, M.D., Endocrinology Fellow
`09/2005 - 06/2007
`09/2008 - 06/2011 Rushika Conroy, M.D., Pediatric Endocrinology Fellow
`07/2009 - 06/2010 Roxanne Dutia, TRANSFORM T32, Clinical and Translational Research
`09/2009 - 06/2012 Clifton Jackness, M.D., Endocrinology Fellow
`09/2010 – 06/2013 Maria Catilo, M.D., Endocrinology Fellow
`11/2011 - 06/2012
`Saachi Sachdev, Medical Student Senior Scholars Project
`10/2013 - 05/2014 Michael T. Caton, Medical Student Senior Scholars Project
`11/2011 - 06/2014
`Kim Nguyen, M.D., Endocrinology Fellow
`06/2014 - 08/2014
`Elizabeth Hoover, Medical Student, NIDDK Summer Research Program
`11/2014 - 05/2015
`Annette Georgia, Medical Student, NIH T35 Pre-Doctoral Trainee
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`6
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0006
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`

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`Jamie Mullally, M.D., Endocrinology Fellow
`09/2014 – 10/2016
`06/2015 – 08/2015 Keesandra Agenor, Dennis Guo, Medical Student, NIDDK Summer
`Research Program
`Beverly Tchang, M.D., Endocrinology Fellow
`08/2016 – 6/2018
`06/2018 – 08/2018 Sheba Ebhote, Medical Student, NIDDK Summer Research Program
`07/2017 – 06/2020 Rachel Arakawa, M.D., Endocrinology Fellow
`2017 – 2022
`Sean Heffron, M.D., NIH K23 Co-mentor
`2021 – 2023
`Ariesta Sideri Gugger, M.D., NIH T32
`2022 – 2024
`Chino Aneke, M.D., Ph.D. Gastroenterology Fellow, NIH T32
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`
`
`PUBLICATIONS
`
`Original, Peer Reviewed Articles:
`
`1. Korner, J., Chun, J., Harter, D., and Axel, R. Isolation and functional expression of a
`mammalian prohormone processing enzyme, murine prohormone convertase 1. Proc. Natl. Acad.
`Sci. USA, 1991, 88:6834-6838
`
`2. Korner, J., Chun, J., O'Bryan, L., and Axel, R. Prohormone processing in Xenopus oocytes:
`Characterization of cleavage signals and cleavage enzymes. Proc. Natl. Acad. Sci. USA, 1991,
`88:11393-11397
`
`3. Chun, J., Korner, J., Kreiner, T., Scheller, R., and Axel, R. The function and
`differential sorting of a family of Aplysia prohormone processing enzymes. Neuron, 1994,
`12:831-844
`
`4. Korner, J., Chua Jr., S.C., Williams, J.A., Leibel, R.L., Wardlaw, S.L. Regulation of
`hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology, 1999,
`70:377-383
`
`5. Korner, J., Wardlaw, S.L., Liu, S.-M., Conwell, I.M., Leibel, R.L., Chua Jr., S.C. Effects of leptin
`receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats.
`Endocrinology, 2000, 141:2465-2471
`
`6. Korner, J., Savontaus, E., Chua Jr., S.C., Leibel, R.L., and Wardlaw, S.L. Differential regulation
`of Agrp and Npy mRNA in the rat hypothalamus. J. of Neuroendocrinology, 2001, 13:959-966
`
`7. Korner, J., Lo, J., Freda, P.U., and Wardlaw, S.L. Weight loss in patients with
`hyperprolactinemia treated with cabergoline. Obesity Research, 2003, 11:311-312
`
`8. Korner, J., Wissig, S., Kim, A., Conwell, I.M., and Wardlaw, S.L. Effects of Agouti-Related
`Protein on metabolism and hypothalamic neuropeptide gene expression. J. of
`Neuroendocrinology, 2003, 15:1116-1121
`
`9. Korner, J., Bessler, M., Cirilo, L.J., Conwell, I.M., Daud, A., Restuccia, N.L., and Wardlaw,
`S.L. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of
`plasma ghrelin, peptide YY and insulin, J. of Clin. End. and Met., 2005, 90:359-365 This paper
`was accompanied by an editorial written by le Roux, C.W., and Bloom, S.R., Why do patients
`lose weight after Roux-en-Y gastric bypass? 90:591-592
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0007
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`10. Korner, J., Inabnet, I., Conwell, I.M., Taveras, C., Daud, A., Olivero-Rivera, L., Restuccia,
`N.L., and Bessler, M., Differential effects of gastric bypass and banding on plasma PYY, ghrelin
`and insulin levels, Obesity, 2006, 14:1553-1561
`
`11. Korner, J., Bessler, M., Inabnet, W., Taveras, C., and Holst, J. Postprandial
`hyperinsulinemia, exaggerated GLP-1 and blunted GIP secretion are associated with
`gastric bypass but not gastric banding. Surg. Obes. Relat. Dis., 2007, 3:597-601
`
`12. Wang, G-J., Tomasi, D., Backus, W., Wang, R., Telang, F., Geliebter, A., Korner, J.,
`Bauman, A., Fowler, J., Thano, P., and Volkow, N.D. Gastric distension activates satiety
`circuitry in the human brain. NeuroImage, 2008, 39:1824-31
`
`13. Korner, J., Punyanitya, M., Taveras, C., McMahon, D.J., Kim, H.J., Inabnet, W., Bessler, M.,
`and Gallagher, D. Sex differences in visceral adipose tissue post-bariatric surgery compared to
`matched non-surgical controls. Int. J. of Body Composition Res., 2008, 6:93-99
`
`14. Inabnet, W.B., Milone, L., Korner, J., Durak, E., Ahmed, L., Pomrantz, J., Harris, P.E., and
`Bessler, M. A rodent model of metabolic surgery for the study of type 2 diabetes and PET
`scanning of beta cell mass. Surg. Obes. Relat. Dis., 2009, 5:212-217
`
`15. Korner,J., Inabnet, W., Febres, G., Conwell, I.M., McMahon, D.J., Salas, R., Taveras, R.,
`Schrope, B., and Bessler, M. Prospective study of gut hormone and metabolic changes after
`adjustable gastric banding and Roux-en-Y gastric bypass. Int. J. Obes, 2009, 33:786-795 PMCID:
`PMC2710396
`
`16. Inabnet, W., Milone, L., Harris, P., Durak, E., Freeby, M.J. Ahmed, L., Lifante, J.-C.,
`Bessler, M., and Korner, J. The utility of [11C] dihydrotetrabenazine (DTBZ) PET scanning in
`assessing β-cell performance after sleeve gastrectomy and duodenal-jejunal
`bypass. Surgery, 2010, 147:303-309
`
`17. Korner, J., Nandi, A., Wright, S., Waitman, J., McMahon, D.J., Bessler, M., Aronne, L.J.
`Implantable gastric stimulator does not prevent the increase in plasma ghrelin levels that occurs
`with weight loss. Obesity, 2011, 19:1935-1939 PMCID: PMC4041394; NIHMS581796
`
`18. Plum, L., Febres, G., Kunreuther, E., Taveras, C., Ahmed, L., Bessler, M., Inabnet, W., and
`Korner, J. Comparison of glucostatic parameters after hypocaloric diet or bariatric surgery and
`equivalent weight loss. Obesity, 2011, 19:2149-2157 PMCID: PMC3670603; NIHMSID:
`NIHMS464707
`
`19. Conroy, R., Girotra, M., Shane, E., McMahon, D.J., Pavlovich, K., Leibel, R.L., Rosenbaum,
`M., and Korner, J., Leptin administration does not prevent the bone mineral metabolism
`changes induced by weight loss. Metabolism, 2011, 60:1222-1226 PMID: 21489573 PMCID:
`PMC3139754
`
`20. Gibson, C., Karmally, W., McMahon, D.J., Wardlaw, S.L., and Korner, J., Randomized pilot
`study of cabergoline, a dopamine receptor agonist: Effects on body weight and glucose
`tolerance in obese adults. Diabetes, Obesity and Metabolism, 2012, 14:335-340 PMID:
`22074059, PMCID: 3290696
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`Apotex v. Novo - IPR2024-00631
`Petitioner Apotex Exhibit 1502-0008
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`21. Page-Wilson, G., Wardlaw, S.L., Khandji, A.G., and Korner, J., Hypothalamic obesity in
`patients with craniopharyngioma: Treatment approaches and the emerging role for gastric
`bypass surgery. Pituitary, 2012, 15:84-92 PMCID: 3641571
`
`22. Kopsombut, G., Shoulson, R., Milone, L., Korner, J., Lifante, J-C., Sebastian, M., and
`Inabnet, W.B. Partial small bowel resection with sleeve gastrectomy increases adiponectin
`levels and improves glucose homeostasis in obese rodents with type 2 diabetes. World J Surg.,
`2012. 36:1432-1438
`
`23. Lifante, J.C., Milone, L., Korner, J., Kopsombut, G., Sebastian, M., and Inabnet, W.B.
`Sleeve gastrectomy imporves glucose homeostasis in Zucker diabetic fatty rats. Obes Surg.
`2012, 22:1110-1116
`
`24. Kartalija, M., Ovrutsky, A.R., Bryan, C.L., Pott, G.B., Fantuzzi, G., Thomas, J., Strand, J.J.,
`Bai, Xi., Ramamoorthy, P., Rothman, M.S., Nagabhushanam, V., McDermott, M., Levin, A.R.,
`Frazer-Abel, A., Gicias, P.C., Korner, J., Iseman, M.D., Shapiro, L., Chan, E.D. Patients with
`non-tuberculous mycobacterial lung disease exhibit unique body and immune phenotypes. Am
`J Respir Crit Care Med., 2013, 187:197-205 PMID: 23144328
`
`24. Korner, J., Conroy, R., Febres, G. McMahon, D.J., Conwell, I., Karmally, W., and Aronne,
`L.J. Randomized double-blind placebo-controlled study of leptin administration after gastric
`bypass. Obesity, 2013, 21:951-956 PMCID: PMC3689870
`
`25. Jackness, C., Karmally, W., Febres, G, Conwell, I., Ahmed, L., Bessler, M., McMahon, D.J.,
`and Korner, J. Very low calorie diet mimics the early beneficial effect of Roux-en-Y bypass on
`insulin sensitivity and beta-cell function in Type 2 diabetic patients. Diabetes, 2013 62:3027-
`3032. PMID: 23610060 PMCID: PMC3749351 This paper was accompanied by a
`commentary: Vella, A., 62:3017-3018
`
`26. Ikramuddin, S., Korner, J., Lee, W-J., Connett, J.E., Inabnet, W.B. III, Billington, C.J.,
`Thomas, A.J., Leslie, D.B. Chong, K., Jeffery, R.W., Ahmed, L., Vella, A., Chuang, L-M.,
`Bessler, M., Sarr, M.G., Swain, J.M., Laqua, P., Jensen, M.D., Bantle, J.P. Roux-en-Y gastric
`bypass vs intensive medical management for the control to type 2 diabetes, hypertension, and
`hyperlipidemia, The Diabetes Surgery Study randomized clinical trial. JAMA, 2013, 309:2240-
`2249
`
`27. Sysko, R., Devlin, M.J., Schebendach, J., Tanofsky-Kraff, M., Zimmerli, E., Korner, J.,
`Yanovski, J.A., Zitsman, J.L., Walsh, B.T. Hormonal responses and test meal intake among
`obese teenagers before and after laparoscopic adjustable gastric banding. Am J Clin Nutr,
`2013, 98:1151-1161 PMID: 23985807
`
`28. Nagareddy, P.R., Gorman, D.J., Stirzaker, R.A., Grant, R., Hong, E.S., Smyth, S.S., Choi,
`S.H., Korner, J., Bornfeldt, K., Fisher, E.A., Dixit, V.D., Tall, A.R., Goldberg, I.J., Murphy, A.J.
`Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell
`Metabolism, 2014, 19:821-835, PMID: 24807222
`
`29.Conroy, R., Febres, G., McMahon, D.J., Thorner, M.O., Gaylinn, B.D., Conwell, I., Aronne,
`L., Korner, J. Recombinant human leptin does not alter gut hormone levels after gastric bypass
`but may attenuate sweet cravings. Int J Endocrinology, 2014, DOI 10.1155/2014/120286
`PMCID: PMC3980779
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`29. Thomas, A.J., Bainbridge, H.A., Schone, J.L., Chen, S-C., Connett, J.E., Ikramuddin, S.,
`Lee, W-J., Jensen, M.D., Leslie, D.B., Korner, J. Recruitment and screening for a randomized
`trial investigating Roux-en-Y gastric bypass versus intensive medical management for treatment
`of type 2 diabetes. Obes Surg, 2014, 24:1875-1880
`
`30. Ikramuddin, S., Billington, C.J., Lee, W-J., Bantle, J.P, Thomas, A.J., Connett, J.E., Leslie,
`D.B., Inabnet, W.B., Jeffery, R.W., Chong, K., Chuang., L-M., Sarr, M.G., Jensen, M.D., Vella,
`A., Ahmed, L., Belani, K., Schone, J.L., Reynolds, A.E., Bainbridge, H.A., Wang, Q., Korner, J.
`Two year outcomes of Roux-en-Y gastric bypass vs intensive medical management for optimal
`diabetes therapy: The Diabetes Surgery Study randomized clinical trial. Lancet Diabetes and
`Endocrinology 2015, 3 (6):412-422 This paper was accompanied by a commentary Peltonen, M.
`2015, 3(6):394-395
`
`31. Nguyen, K., Billington, C., Vella, A., Wang, Q, Ahmed, L., Bantle, J., Bessler, M., Connett,
`J.E., Inabnet, W.B., Thomas, A., Ikramuddin, S., Korner, J. Preserved insulin secretory
`capacity and weight loss are the predominant predictors of glycemic control in patients with type
`2 diabetes randomized to Roux-en-Y gastric bypass. Diabetes, 2015, 64:3104-3110 PMCID:
`PMC4542441
`
`32. Sachdev, S., Wang, Qi, Billington, C., Connett, J., Ahmed, L., Inabnet, W., Chua, S.,
`Ikramuddin, S., Korner, J. FGF19 and bile acids increase following Roux-en-Y gastric bypass
`but not after medical management in patients with type 2 diabetes. Obes Surg, 2015 DOI
`10.1007/s11695-015-1834-0
`
`33. Raghavendra Rao, R., Roche, A., Febres, G., Bessler, M., Tso, P., Korner, J. Circulating
`apolipoprotein A-IV pre-surgical levels are associated with improvement in insulin sensitivity
`after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis 2016 Oct 26 pii: S1550-
`7289(16)30775-4. doi: 10.1016/j.soard.2016.10.019. [Epub ahead of print]
`
`34. Page-Wilson G, Nguyen KT, Atalayer D, Meece K, Bainbridge HA, Korner J, Gordon RJ,
`Panigrahi SK, White A, Smiley R, Wardlaw SL. Evaluation of CSF and Plasma Biomarkers of
`Brain Melanocortin Activity in Response to Caloric Restriction in Humans. Am J Physiol
`Endocrinol Metab. 2016 Nov 15:ajpendo.00330.2016. doi: 10.1152/ajpendo.00330.2016. [Epub
`ahead of print] PubMed PMID: 27894065.
`
`35. Ikramuddin S, Korner J, Lee WJ, Bantle JP, Thomas AJ, Connett JE, Leslie DB, Inabnet
`WB 3rd, Wang Q, Jeffery RW, et al. Durability of Addition of Roux-en-Y Gastric Bypass to
`Lifestyle Intervention and Medical Management in Achieving Primary Treatment Goals for
`Uncontrolled Type 2 Diabetes in Mild to Moderate Obesity: A Randomized Control Trial.
`Diabetes Care. 2016 Sep;39(9):1510-8. PubMed PMID: 27311493; PubMed Central PMCID:
`PMC5001141.
`
`36. Chong K, Ikramuddin S, Lee WJ, Billington CJ, Bantle JP, Wang Q, Thomas AJ, Connett
`JE, Leslie DB, Inabnet WB 3rd, … Korner J, Chuang L-M. National Differences in Remission of
`Type 2 Diabetes Mellitus After Roux-en-Y Gastric Bypass Surgery-Subgroup Analysis of 2-Year
`Results of the Diabetes Surgery Study Comparing Taiwanese with Americans with Mild Obesity
`(BMI 30-35 kg/m2). Obes Surg. 2017 27:1189-1195
`
`37. Ikramuddin S, Korner J, Lee WJ, Thomas AJ, Connett JE, Bantle JP, Leslie DB, Wang Q,
`Inabnet, WB III, Jeffery RW, et al. Lifestyle intervention and medical management with vs
`without Roux-en-Y gastric bypass and control of hemoglobin A1c, LDL cholesterol, and systolic
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`blood pressure at 5 years in the Diabetes Surgery Study. JAMA. 2018, 319:266-278
`PMC5833547
`
`
`38. Blumenfeld NR, Kang HJ, Fenzl A, Song Z, Chung JJ, Singh R, Johnson R, Karakecili A,
`Feranil JB, Rossen NS, Zhang V, Jaggi S, McCarty B, Bessler S, Schwartz GJ, Grant R, Korner
`J, Kiefer FW, Gillette BM, Sia SK A direct tissue-grafting approach to increasing endogenous
`brown fat. Scientific Reports. 2018, 8:7957 DOI:10.1038/s41598-018-25866-y PMC 5962549
`
`39. Greenlee H, Lew DL, Hershman DL, Newman, VA, Hansen, L, Hartman SJ, Korner J, et al.
`Phase II feasibility study of a weight loss intervention in female breast and colorectal cancer
`survivors (SWOG S1008). Obesity. 2018, 26:1539-1549.
`
`40. Page-Wilson G, Peters J, Panigrahi SK, Jacobs TP, Korner J, Otten M, Bruce JN, Wardlaw
`SL. Plasma AgRP and cortisol levels in Cushing’s Disease: Evidence for the regulation of
`AgRP by glucocorticoids in humans. JCEM. 2019 Mar 1;104(3):961-969 PMC6364508
`
`41. Mullally, J., Febres, G., Bessler, M., Korner, J. Sleeve gastrectomy and Roux-en-Y gastric
`bypass achieve similar early improvements in beta-cell function in obese patients with Type 2
`Diabetes. Scientific Reports. 2019 9(1):1880 PMC6372630
`
`42. Georgia A., Catilo Asnis MC, Febres G, Tsang A, Bessler M, Korner J. Roux-en-Y gastric
`bypass is associated with hyperinsulinemia but not increased maximal beta-cell function J of the
`Endocrine Society. 2019 3(3):632-642 PMC6391719
`
`43. Jahansouz C, Xu H, Kizy S, Thomas AJ, Josephrajan A, Hertzel AV, Foncea R, Connett JC,
`Billington CJ, Jensen M, Korner J, Bernlohr DA, Ikramuddin S. Serum FABP4 concentrations
`decrease after Roux-en-Y gastric bypass but not after intensive medical management. Surgery.
`2019 Mar;165(3):571-578 PMC6389424
`
`44. Korner J, Cline GW, Slifstein M, Barba P, Rayat GR, Febres G, Leibel RL, Maffei
`A, Harris PE. A role for foregut tyrosine metabolism in glucose tolerance. Mol Metab. 2019
`23:37-50 PMC6479665
`
`
`45. Tsouristakis A, Febres G, McMahon DJ, Tchang B, Conwell IM, Tsang AJ, Ahmed L, Bessler
`M, Korner J. Long-term modulation of appetitive hormones and sweet cravings after adjustable
`gastric banding and Roux-en-Y gastric bypass. Obesity Surgery 2019 29:3698-3705
`PMC6851479
`
`46. Arakawa R, Febres G, Cheng B, Krikhely A, Bessler M, Korner J. Prospective study of gut
`hormone and metabolic changes after laparoscopic sleeve gastrectomy and Roux-en-Y gastric
`bypass. PLoS ONE 2020 15(7): e0236133 PMC7371190
`https://doi.org/10.1371/journal.pone.0236133
`
`47. Mullally JA, Chung WK, LeDuc CA, Reid TJ, Febres G, Holleran S, Ramakrishanan R, Korner
`J. Weight loss response to naltrexone/bupropion is modulated by the Taq1A genetic variant near
`DRD2 (rs1800497): A pilot study. Diabetes Obesity and Metabolism 2021;23(3):850-3.
`PMC8106923
`
`48. Mitrani LR, Goldentahl I, Leskowitz J, Wan EY, Dizon J, Saluja D, Creber RM, Turchioe MR,
`Sciacca RR, Garan H, Hickey, KT, Korner J, Biviano, AB. Risk factor management of atrial
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`fibrillation using mHealth: The Atrial Fibrillation – Helping Address Care with Remote Technology
`(AF-HEART) Study. Cardiovascular Digital Health Journal 2021
`
`49. Page-Wilson G, Arakawa R, Nemeth S, Bell F, Girvin Z, Tuohy M-C, Lauring M, Laferrere B,
`Reyes-Soffer G, Natarajan K, Chen RJ, Kurlansky P, Korner J. Obesity is independently
`associated with septic shock, renal complications, and mortality in a multiracial patient cohort
`hospitalized with COVID-19. PLoS One 2021 16(8):e0255811 PMC8360607
`
`50. Aristea Sideri Gugger, Cara Dimino, Sunil K. Panigrahi, Laurel Mayer, Richard M. Smiley
`Judith Korner and Sharon L. Wardlaw. Defining Predictors of Weight Loss Response to
`Lorcaserin. The Journal of Clinical Endocrinology & Metabolism, 2023;108 (9), 2262–
`2271. https://doi.org/10.1210/clinem/dgad139
`
`
`Books and Chapters:
`
`1. Korner, J., and Aronne, L.J. (2003) Integrative Approach to Disease: Obesity. In: Rakel, D. ed.
`Integrative Medicine. W.B. Saunders Co. 257-265
`
`2. Korner, J., Klein, S. and Aronne, L.J. (2003) Approach to the Patient with Obesity. In: Yamada,
`T. ed. Textbook of Gastroenterology. 4th edition. Lippincott Williams & Wilkins, New York, NY 752-
`759
`
`3. Nguyen, K., and Korner, J. The Effect of Bariatric Surgery on Insulin Secretion. In: Metabolic
`Surgery and Treatment of Diabetes.
`
`4. Reid, T.J., Korner, J. (2017) Medical Complications of Obesity in Adults. In: Eating Disorders
`and Obesity: A Comprehensive Handbook, 3rd edition, edited by Kelly D. Brownell and B. Timothy
`Walsh. Guilford Press, Ch. 73.
`
`5. Reid, T.J., Korner, J. (2022) Medical and Surgical Treatment of Obesity. Nutrition in the
`Practice of Medicine: A Practical Approach. Medical Clinics of North America, edited by David
`S. Seres. Elsevier, 106:837-852
`
`
`Reviews, Editorials, Consensus Statement:
`
`1. Korner, J., and Eberle, M.A. (2001) An Update on the Science and Therapy of Obesity and Its
`Relationship to Osteoarthritis. Current Rheumatology Reports. 3:101-106
`
`2. Korner, J., and Aronne, L.J. (2003) The Emerging Science of Body Weight Regulation and its
`Impact on Obesity Treatment. Journal of Clinical Investigation, 111:565-570
`
`3. DeNino, W.F., Korner, J., and Aronne, L.J. (2003) Central control of energy homeostasis. Curr
`Opin Endocrinol Diabetes, 10:330-333
`
`4. Korner, J., and Leibel, R.L. (2003) To eat or not to eat – how the gut talks to the brain. New
`England J of Med, 349:926-928
`
`5. Korner, J., and Aronne, L.J. (2004) Pharmacological approaches to weight reduction:
`therapeutic targets. J. of Clin. End. and Met, 89:2616-2621
`
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`6. Lee, M., and Korner, J. (2008) Review of Physiology, Clinical Manifestations, and Management
`of Hypothalamic Obesity in Humans. Pituitary, 12:87-95
`
`7. Korner, J., Woods, S., and Woodworth, K. (2009) Regulation of Energy Homeostasis and
`Health Consequences in Obesity. Amer J of Medicine 122:S12-S18
`
`8. Harvey, E.J., Arroyo, K., Korner, J., and Inabnet, W.B. (2010) Hormone changes affecting
`energy homeostasis after metabolic surgery. Mount Sinai J of Medicine, 77:446-465 PMID:
`20960548
`
`9. Nguyen, K.T., and Korner, J. (2014) The sum of many parts: Potential mechanisms for
`improvement in glucose homeostasis after bariatric surgery. Current Diabetes Reports, 14:481-
`485 PMID: 24705810, PMCID: PMC4059201
`
`10. Yu, Yi-Hao, Vasselli, J.R., Zhang, Y., Mechanick, J.I., Korner, J., Peterli, R. (2015). Metabolic
`versus hedonic obesity – A conceptual distinction and its clinical implications. Obesity Rev. 16(3):
`234-47. PMCID: 5053237.
`
`11. Rubino F, Nathan DM, Eckel RH, Schauer PR, Alberti KG, Zimmet PZ, Del Prato S, Ji L,
`Sadikot SM, H