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`Stool DNA Testing For Colon Cancer | ScienceDaily
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`Stool DNA Testing For Colon Cancer
`
`Date:
`
`December 13, 2006
`
`Source:
`
`The Mount Sinai Hospital / Mount Sinai School of Medicine
`
`Summary:
`
`A prospective, multi-center study of stool DNA testing has found that a new test
`demonstrated an 88 percent sensitivity for colorectal cancer, and with equal detection
`across all stages of cancer, regardless of the cancer's location in the colon. The study
`was published online in the American Gastroenterological Association's journal, Clinical
`Gastroenterology and Hepatology.
`
`FULL STORY
`
`Mount Sinai School of Medicine and EXACT Sciences Corporation have
`announced the publication of results from a prospective, multi-center study of
`stool DNA testing. The study found that the test demonstrated an 88%
`sensitivity for colorectal cancer, and with equal detection across all stages of
`cancer, regardless of the cancer's location in the colon.
`
`The study was published online in the American Gastroenterological Association's journal, Clinical
`Gastroenterology and Hepatology, and will appear in the January 2007 print issue.
`
`"This study confirms that stool-based DNA technologies can achieve high sensitivities for detecting
`colorectal cancer," stated Steven Itzkowitz, M.D., principal investigator and Professor and Associate
`Director of Gastroenterology at Mount Sinai School of Medicine.
`
`"For those individuals who are unwilling or unable to undergo colonoscopy, stool DNA testing offers
`a valuable and patient-friendly screening option. These results also underscore that as new markers
`and technologies are developed and validated, they can readily be incorporated into existing stool
`DNA tests to improve cancer detection and, ultimately, patient outcomes."
`
`The published study, entitled "Improved Fecal DNA Test for Colorectal Cancer Screening," evaluated
`162 patients, 40 individuals with cancer and 122 individuals with normal colonoscopies.
`
`An enhanced marker panel, using a refined DNA capture and stabilization process, detected 88% of
`cancers with a specificity of 82%.
`
`"This publication is further validation that stool DNA technology offers a powerful tool for physicians
`and patients in detecting colorectal cancer," said Don Hardison, EXACT Sciences' President and
`CEO.
`
`https://www.sciencedaily.com/releases/2006/12/061213104115.htm#
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`1/9/24, 11:49 AM
`Stool DNA Testing For Colon Cancer | ScienceDaily
`"Without new, non-invasive approaches such as stool DNA testing, it will be difficult to increase
`current colorectal screening and decrease mortality rates, a major goal for our company as well as a
`mandate of the American Cancer Society."
`
`Colorectal cancer is the second leading cause of cancer deaths in the U.S. and more than half of the
`over 80 million people over the age of 50 have never been screened. A recent NCI study published
`in the American Cancer Society's journal, Cancer, projected that, using traditional screening
`approaches, U.S. screening and mortality reduction goals cannot be achieved even under the most
`optimistic of scenarios. The report concluded that consideration of new screening technologies, such
`as stool DNA testing, is warranted.
`
`Story Source:
`Materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Content
`may be edited for style and length.
`
`Cite This Page:
`
`MLA
`
`APA
`
`Chicago
`
`The Mount Sinai Hospital / Mount Sinai School of Medicine. "Stool DNA Testing For Colon Cancer."
`ScienceDaily. ScienceDaily, 13 December 2006. <www.sciencedaily.com/releases/2006/12/
`061213104115.htm>.
`
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`Geneoscopy Exhibit 1077, Page 2
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`1/9/24, 11:49 AM
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`https://www.sciencedaily.com/releases/2006/12/061213104115.htm#
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`Geneoscopy Exhibit 1077, Page 3
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