8360351
`
`March 28, 2023
`
`THIS IS TO CERTIFY THAT ANNEXED IS A TRUE COPY FROM THE
`RECORDS OF THIS OFFICE OF THE FILE WRAPPER AND CONTENTS
`OF:
`
`APPLICATION NUMBER: 17/352,892
`FILING DATE: June 21, 2021
`PATENT NUMBER: 11253572
`ISSUE DATE: February 22, 2022
`
`Celltrion Exhibit 1014
`Page 1
`
`

`

`DocCode — SEQ.TXT
`
`SCORE Placeholder Sheet for IFW Content
`
`Application Number: 17352892
`
`Document Date: 06/21/2021
`
`The presence of this form in the IFW record indicates that the following document type was received
`in electronic format on the date identified above. This content is stored in the SCORE database.
`
`Since this was an electronic submission, there is no physical artifact folder, no artifact folder is
`recorded in PALM, and no paper documentsor physical media exist. The TIFF images in the IFW
`record were created from the original documents that are stored in SCORE.
`
`SequenceListing
`
`At the time of documententry (noted above):
`e USPTO employees may access SCORE content via DAV or via the SCORE web page.
`e External customers may access SCORE content via PAIR using the Supplemental Content
`tab.
`
`Form Revision Date: March 1, 2019
`
`Celltrion Exhibit 1014
`Page 2
`
`Celltrion Exhibit 1014
`Page 2
`
`

`

`Eye Disorders”
`
`PRELIMINARY
`AMENDMENT
`Under CFR 1115
`
`Ades to:
`Mail Stop Patent Application
`Commissioner for Patents
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`Title:
`
`Electronically Filed
`
`Group Art Unit
`
`To Be Assigned
`To Be Assigned
`“Use of a VEGF Antagonist to Treat Angiogenic
`
`Sir:
`
`Prior to the examination of the above-referenced application on the merits, please enterthe
`amendments below.
`
`Amendments to the claims begin on page2.
`
`Remarksbegin on page 7.
`
`Celltrion Exhibit 1014
`Page 3
`
`Celltrion Exhibit 1014
`Page 3
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`AMENDMENTSTO THE CLAIMS
`
`1. - 20. (Canceled)
`
`21.
`
`(New) A methodoftreating an angiogenic eye disorderin a patient in need
`
`thereof comprising sequentially administering to the patient by intravitreal injection a single initial dose
`
`of 2 mg of aflibercept, followed by one or more secondary doses of 2 mg of aflibercept, followed by one
`
`or more tertiary doses of 2 mg ofaflibercept;
`
`wherein each secondary dose is administered approximately 4 weeks following
`
`the immediately preceding dose; and
`
`wherein each tertiary dose is administered approximately 8 weeks following the
`
`immediately preceding dose;
`
`wherein the patient achieves a gain in visual acuity within 52 weeks following
`
`the initial dose.
`
`22.
`
`(New) The method of claim 21 wherein the patient achieves a gain in Best
`
`Corrected Visual Acuity (BCVA) according to Early Treatment Diabetic Retinopathy Study (ETDRS)
`
`letter score.
`
`23.
`
`(New) The method of claim 22 wherein the patient gains at least 7 letters Best
`
`Corrected Visual Acuity (BCVA) according to Early Treatment Diabetic Retinopathy Study (ETDRS)
`
`letter score.
`
`24.
`
`(New) The method of claim 23 wherein the patient achieves the gain in visual
`
`acuity within 24 weeks followingtheinitial dose.
`
`25.
`
`(New) The method of claim 23 wherein only two secondary dosesare
`
`administered to the paticnt.
`
`Celltrion Exhibit 1014
`Page 4
`
`Celltrion Exhibit 1014
`Page 4
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`26.
`
`(New) The method of claim 23 wherein the aflibercept is formulated as an
`
`isotonic solution.
`
`27.
`
`(New) The method of claim 23 wherein the aflibercept is formulated with a non-
`
`ionic surfactant.
`
`28.
`
`(New) The method of claim 22 wherein the patient gains at least 8 letters Best
`
`Corrected Visual Acuity (BCVA) according to Early Treatment Diabetic Retinopathy Study (ETDRS)
`
`letter score.
`
`29.
`
`(New) The method of claim 28 wherein the patient achieves the gain in visual
`
`acuity within 24 weeks following the initial dose.
`
`30.
`
`(New) The method of claim 22 wherein the patient gains at least 9 letters Best
`
`Corrected Visual Acuity (BCVA) according to Early Treatment Diabetic Retinopathy Study (ETDRS)
`
`Ictter score.
`
`31.
`
`(New) The method of claim 30 wherein only two secondary doses are
`
`administered to the patient.
`
`32.
`
`(New) The method of claim 30 wherein the aflibercept is formulated as an
`
`isotonic solution.
`
`33.
`
`(New) The method of claim 30 wherein the aflibercept is formulated with a non-
`
`ionic surfactant.
`
`34,
`
`(New) The method of claim 21 wherein exclusion critcria for the patient include
`
`both of:
`
`(1)active ocular inflammation; and
`
`(2) active ocular or periocular infection.
`
`Celltrion Exhibit 1014
`Page 5
`
`Celltrion Exhibit 1014
`Page 5
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`35.
`
`(New) A method oftreating diabetic macular edemain a patient in need thereof
`
`comprising sequentially administering to the patient a single initial dose of 2 mg ofaflibercept, followed
`
`by one or more secondary doses of 2 mg of aflibercept, followed by one or moretertiary doses of 2 mg
`
`of aflibercept;
`
`wherein cach secondary dosc is administered to the patient by intravitreal
`
`injection approximately 4 weeks following the immediately preceding dose; and
`
`wherein each tertiary dose is administered to the patient by intravitreal injection
`
`approximately 8 weeks following the immediately preceding dose.
`
`36.
`
`(New) The method of claim 35 wherein the patient achieves a gain in visual
`
`acuity within 52 weeks following the initial dose.
`
`37.
`
`(New) The method of claim 36 wherein the patient gains at least 9 letters Best
`
`Corrected Visual Acuity (BCVA) according to Early Treatment Diabetic Retinopathy Study (ETDRS)
`
`letter score.
`
`38.
`
`(New) The method of claim 37 wherein the aflibercept is formulated as an
`
`isotonic solution.
`
`39,
`
`(New) The method of claim 37 wherein the aflibercept is formulated with a non-
`
`ionic surfactant.
`
`40.
`
`(New) The method of claim 37 wherein the patient achicves a gain in visual
`
`acuily within 24 wecks following the initial dose.
`
`Al.
`
`(New) The method of claim 36 wherein the patient gains at least 8 letters Best
`
`Corrected Visual Acuity (BCVA) according to Early Treatment Diabetic Retinopathy Study (ETDRS)
`
`letter score.
`
`Celltrion Exhibit 1014
`Page 6
`
`Celltrion Exhibit 1014
`Page 6
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`42.
`
`(New) The method of claim 41 wherein the aflibercept is formulated as an
`
`isotonic solution.
`
`43.
`
`(New) The method of claim 41 wherein the aflibercept is formulated with a non-
`
`ionic surfactant.
`
`44,
`
`(New) The method of claim 35 wherein only two secondary dosesare
`
`administered to the patient.
`
`45.
`
`(New) The method of claim 35 wherein four secondary doses are administered to
`
`the patient.
`
`A6.
`
`(New) A methodoftreating age related macular degeneration in a patient in need
`
`thereof comprising sequentially administering to the patient a single initial dose of 2 mg of aflibercept,
`
`followed by one or more secondary doses of 2 mg ofaflibercept, followed by one or moretertiary doses
`
`of 2 mg of aflibercept,;
`
`wherein cach secondary dose is administered to the patient by intravitreal
`
`injection approximately 4 weeks following the immediately preceding dose; and
`
`wherein each tertiary dose is administered to the patient by intravitreal
`
`injection approximately 8 weeks following the immediately preceding dose;
`
`wherein the methodis as effective in achieving a gain in visual acuity as
`
`monthly administration of 0.5 mg of ranibizumab byintravitreal injection in humansubjects with
`
`age-related macular degeneration at 52 weeks following the initial dose.
`
`47.
`
`(New) The method of claim 46 wherein only two secondary doscs are
`
`administered to the patient.
`
`48.
`
`(New) The method of claim 46 wherein the gain in visual acuity is measured
`
`using the Early Treatment Diabetic Retinopathy Study (ETDRS) letter score.
`
`Celltrion Exhibit 1014
`Page 7
`
`Celltrion Exhibit 1014
`Page 7
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`49,
`
`(New) A method oftreating age-related macular degeneration in a patient in need
`
`thereof comprising sequentially administering to the patient a single initial dose of 2 mg of aflibercept,
`
`followed by one or more secondary doses of 2 mg of aflibercept, followed by one or moretertiary doses
`
`of 2 mg of aflibercept;
`
`wherein cach secondary dose is administered to the patient by intravitreal
`
`injection approximately 4 weeks following the immediately preceding dose; and
`
`wherein each tertiary dose is administered to the patient by intravitreal
`
`injection approximately 8 weeks following the immediately preceding dose;
`
`wherein the methodis as effective in maintaining visual acuity as monthly
`
`administration of 0.5 mg of ranibizumabby intravitreal injection in human subjects with age-
`
`related macular degeneration at 52 weeks following theinitial dose.
`
`50.
`
`(New) The method of claim 49 wherein maintenanceof visual acuity means loss
`
`of less than 15 letters Best Corrected Visual Acuity (BCVA) as measured by using the Early Treatment
`
`Diabetic Retinopathy Study (ETDRS) letter score.
`
`Celltrion Exhibit 1014
`Page 8
`
`Celltrion Exhibit 1014
`Page 8
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`REMARKS UNDER 37 CFR § 1.115
`
`Formal Matters
`
`Claims 21-50 are pending after entry of the amendments set forth herein.
`
`Original claims 1-20 are canceled without prejudice.
`
`Claims 21-50 are added here.
`
`Support for new claims 21-50 can be found in originally pending nowcanceled claims 1-20, and
`
`throughout the specification.
`
`No new matter has been added.
`
`SEQUENCE LISTING
`
`Applicants submit herewith the attached Sequence Listing in .txt format. As set out in MPEP
`
`§2422.03(a), the Office has advised that if the sequence listing text file submitted via EFS-Web
`
`complies with the requirements of 37 CFR 1.824(a)(2)-(6) and (b)(.e., is a compliant sequencelisting
`
`ASCIItext file), the text file will serve as both the paper copy required by 37 CFR 1.821(c) and the
`
`computerreadable form (CRF) required by 37 CFR 1.821(e). Further, per MPEP §2422.03(a), neither
`
`(1) a second copy of the sequencelisting in a PDFfile; nor (2) a statement under 37 CFR 1.821(f)
`
`(indicating that the paper copy and CRF copyof the sequencelisting are identical) should be submitted.
`
`The Sequence Listing was prepared with the software FASTSEQ for Windowsversion 4.0, and
`
`conforms to the Patent Office guidelines. Applicant respectfully submits that the subject application is
`
`in adherence to 37 CPR §$ 1.821-1.825. I hereby certify that the enclosed submission includes no new
`matter.
`
`Applicants respectfully submit that the present patent application is nowin compliance with 37
`
`CFR §§ 1.821-1.825.
`
`STATEMENT UNDER 37 C.F.R,
`
`$§1.56 AND 1,2
`
`Applicants hereby advise the Examinerof the status of a co-pending application in compliance
`
`with the Applicant’s duty to disclose under 37 C.F.R. §$1.56 and 1.2 (see also MPEP §2001.06(b)) as
`
`discussed in McKesson Info. Soin. Inc., v. Bridge Medical Inc., 487 F.3d 897; 82 USPQ2d 1865 (Fed.
`
`Cir. 2007).
`
`Celltrion Exhibit 1014
`Page 9
`
`Celltrion Exhibit 1014
`Page 9
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`The Applicant wishes to bring to the Examiner’s attention U.S. Patent Application No.
`
`13/940,370, filed July 12, 2013 which issued on February 9, 2016 as U.S. Patent 9,254,338, for
`
`which Inter Partes Review No. IPR2021-00881 wasfiled on May 5, 2021.
`
`The Applicant wishes to bring to the Examiner’s attention U.S. Patent Application No.
`
`14/972,560, filed December 17, 2015 which issued on June 6, 2017 as U.S. Patent No. 9,669,069,
`
`for which Inter Partes Review No. IPR2021-00880 wasfiled on May 5, 2021.
`
`The Applicant wishes to bring to the Examiner’s attention U.S. Patent Application No.
`
`15/471,506, filed March 28, 2017 which issued on November 20, 2018 as U.S. Patent No. 10,130,681.
`
`The Applicant wishes to bring to the Examincr’s attention U.S. Patent Application No.
`
`16/055,847, filed August 6, 2018 which will issue on December 8, 2020 as U.S. Patent No. 10,857,205.
`
`The Applicant wishes to bring to the Examiner’s attention U.S. Patent Application No.
`
`16/159,282, filed October 12, 2018 which issued on November 10, 2020 as U.S. Patent No. 10,828,345,
`
`for which Post-Grant Review No. PGR2021-00035 wasfiled on January 7, 2021.
`
`The Applicant wishes to bring to the Examiner’s attention co-pending U.S. Patent Application
`
`No. 16/397,267, filed April 29, 2019, which issucd on January 12, 2021 as U.S. Patent No.
`
`10,888,601.
`
`The Applicant wishes to bring to the Examiner’s attention co-pending U.S. Patent Application
`
`No. 17/072,417, filed October 16, 2020 for which no actions have been mailed.
`
`The Applicant wishesto bring to the Examiner’s attention co-pending U.S. Patent Application
`
`17/112,063, filed December 4, 2020 for which no actions have been mailed.
`
`The Applicant wishes to bring to the Examiner’s attention co-pending U.S. Patent Application
`
`No. 17/112,404 filed December4, 2020 for which no actions have been mailed.
`
`The Applicant wishesto bring to the Examiner’s attention co-pending U.S. Patent Application
`
`No. 17/350,958 filed June 17, 2021 for which no actions have been mailed.
`
`These documents are available on PAIR, and thus are not provided with this
`
`communication. Please inform the undersigned if there is any difficulty in obtaining the documents
`
`from PAIR.
`
`Celltrion Exhibit 1014
`Page 10
`
`Celltrion Exhibit 1014
`Page 10
`
`

`

`Atty Dkt. No.: REGN-008CIPCON10
`USSN: To Be Assigned
`
`CONCLUSION
`Applicant submits thatall of the claims are in condition for allowance, which action is requested.
`
`If the Examinerfinds that a telephone conference would expedite the prosecution of this application,
`
`please telephone the undersigned at the number provided.
`
`The Commissioncris hercby authorized to charge any underpaymentof fees up to a strict limit of
`
`$3,000.00 beyond that authorized on the credit card, but not more than $3,000.00 in additional fees due
`
`with any communication for the above referenced patent application, including but not limited to any
`
`necessary fees for extensions of time, or credit any overpayment of any amount to Deposit Account No.
`
`50-0815, order number REGN-O08CIPCON10.
`
`Respectfully submitted,
`BOZICEVIC, FIELD & FRANCIS LLP
`
`Date:
`
`
`Junc 21, 2021
`By:
`/Karl Bozicevic, Reg. No. 28,807/
`Karl Bozicevic, Reg. No. 28.807
`
`Bozicevic, Field & Francis LLP
`201 Redwood Shores Parkway, Suite 200
`Redwood City, California 94065
`Telephone: (650) 327-3400
`Direct: (650) 833-7735
`Facsimile: (650) 327-3231
`
`Celltrion Exhibit 1014
`Page 11
`
`Celltrion Exhibit 1014
`Page 11
`
`

`

`Electronic Patent Application Fee Transmittal
`
`Application Number:
`
`Filing Date:
`
`Title of Invention:
`
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
`
`First Named Inventor/Applicant Name:
`
`George YANCOPOULOS
`
`
`
`Filer: Karl Bozicevic/Kimberly Zuehlke
`
`Attorney Docket Number:
`
`REGN-OO8CIPCON10
`
`Filed as Large Entity
`
`Filing Fees for Track | Prioritized Examination - Nonprovisional Application under 35 USC 111(a)
`
`
`
`
`
`
`
`
`
`Miscellaneous-Filing:
`
`Sub-Total in
`Description USD($) Fee Code Quantity Amount
`
`
`
`
`
`Basic Filing:
`
`UTILITY APPLICATION FILING
`
`UTILITY SEARCH FEE
`
`
`UTILITY EXAMINATION FEE
`
`REQUEST FOR PRIORITIZED EXAMINATION
`
`Claims:
`
`
`
`
`
`Celltrion Exhibit 1014
`Page 12
`
`Celltrion Exhibit 1014
`Page 12
`
`

`

`
`
`
`
`Quantity
`
`Amount
`
`Sub-Total in
`USD(S)
`
`
`
`Total in USD ($)
`
`PUBL. FEE- EARLY, VOLUNTARY, OR NORMAL
`
`Description
`
`Fee Code
`
`PROCESSING FEE, EXCEPT PROV. APPLS.
`
`Patent-Appeals-and-Interference:
`
`Post-Allowance-and-Post-Issuance:
`
`
`
`Extension-of-Time:
`
`Celltrion Exhibit 1014
`Page 13
`
`Celltrion Exhibit 1014
`Page 13
`
`

`

` a T
`
`he Director of the USPTO is hereby authorized to charge indicated fees and credit any overpaymentas follows:
`
`Electronic AcknowledgementReceipt
`
`43040441
`EFS ID:
`
`
`Application Number:
`
`17352892
`
`Confirmation Number:
`
`5070
`
`Title of Invention:
`
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
`
`
`
`First Named Inventor/Applicant Name: George YANCOPOULOS
`
`Customer Number:
`
`96387
`
`a
`
`Filing Date:
`
`Time Stamp:
`
`15:17:13
`
`Application Type:
`
`Utility under 35 USC 11 1{a)
`
`Paymentinformation:
`
`Celltrion Exhibit 1014
`Page 14
`
`Celltrion Exhibit 1014
`Page 14
`
`

`

`
`
`File Listing:
`
`Document
`DocumentDescription
`File Name
`File Size(Bytes)/
`Multi
`Pages
`
`
`Number Message Digest|Part/.zip) (ifappl.)
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`Application Data Sheet
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`Information:
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`The pagesize in the PDFis too large. The pages should be 8.5 x 11 or A4.If this PDF is submitted, the pages will be resized upon entry into the
`Image File Wrapper and mayaffect subsequent processing
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`TrackOne Request
`
`REGN-008CIPCON10_2021-06-3
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`1d110eb¢30S5e8ce3ea8cde0bdf4aa6d5485}
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`SequenceListing
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`Claims
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`Celltrion Exhibit 1014
`Page 15
`
`Celltrion Exhibit 1014
`Page 15
`
`

`

`Oath or Declaration filed
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`REGN-GO8CIPCON10_declaratio
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`Transmittal Letter
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`REGN-008CIPCON10_2021-06-3
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`Information Disclosure Statement (IDS)|REGN-O08CIPCON10_2021-06-3
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`1_IDS_SBO8A.pdf
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`Warnings:
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`
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`
`REGN-008CIPCON10_2021-06-23
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`
`Information:
`
`SequenceListing (Text File)
`
`REGN-OO8CIPCON10_SeqList.
`bt
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`Warnings:
`
`Celltrion Exhibit 1014
`Page 16
`
`Celltrion Exhibit 1014
`Page 16
`
`

`

`Fee Worksheet (SB06)
`
`fee-info.pdf
`
`cea833df2cfio6 1 0SbEScd32215d976d8.089)
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`Warnings:
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`the application.
`
`New Applications Under 35 U.S.C. 111
`If a new applicationis being filed and the application includes the necessary componentsfora filing date (see 37 CFR
`1.53(b)-(d) and MPEP 506), a Filing Receipt (37 CFR 1.54) will be issued in due course and the date shownonthis
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`If a timely submission to enter the national stage of an international application is compliant with the conditions of 35
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`national stage submission under35 U.S.C. 371 will be issued in addition to the Filing Receipt, in due course.
`New International Application Filed with the USPTOas a Receiving Office
`If a new international application is being filed and the international application includes the necessary componentsfor
`an international filing date (see PCT Article 11 and MPEP 1810), a Notification of the International Application Number
`andofthe International Filing Date (Form PCT/RO/105)will be issued in due course, subject to prescriptions concerning
`national security, and the date shown on this AcknowledgementReceiptwill establish the international filing date of
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`Total Files Size (in bytes)
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`1077067
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`This Acknowledgement Receipt evidencesreceipt on the noted date by the USPTOof the indicated documents,
`characterized by the applicant, and including page counts, where applicable.It serves as evidence of receipt similar to a
`Post Card, as described in MPEP 503.
`
`Celltrion Exhibit 1014
`Page 17
`
`Celltrion Exhibit 1014
`Page 17
`
`

`

`PTO/AIA/14
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`
`
`Attorney Docket Number
`REGN-OO8CIPCON10
`
`oe
`.
`Application Data Sheet 37 CFR 1.76
`
`Application Number
`
`Title of Invention
`
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
`
`The application data sheet is part of the provisional or nonprovisional application for whichit is being submitted. The following form contains the
`bibliographic data arrangedin a format specified by the United States Patent and TrademarkOffice as outlined in 37 CFR 1.76.
`This document may be completed electronically and submitted to the Office in electronic format using the Electronic Filing System (EFS) or the document
`may be printed and includedin a paperfiled application.
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`Secrecy Order 37 CFR 5.2:
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`Portions or all of the application associated with this Application Data Sheet mayfall under a Secrecy Order pursuant to 37
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`CFR 5.2 (Paperfilers only. Applications thatfall under Secrecy Order may notbe filed electronically.)
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`Inventor Information:
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`1
`Inventor
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`Legal Name
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`Prefix) Given Name
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`Middle Name
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`George
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`Family Name
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`YANCOPOULOS
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`Suffix
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`Residence Information (Select One)
`(@) US Residency
`©) Non USResidency
`(©) Active US Military Service
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`City|Yorktown Heights Country of Residence ||USState/Province NY
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`Mailing Address of Inventor:
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`c/o Regeneron Pharmaceuticals,Inc.
`777 Old SawMill River Road
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`Address 1
`Address 2
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`City
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`Tarrytown
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`State/Province
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`NY
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`Postal Code US 10591 Country i
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`All Inventors Must Be Listed - Additional Inventor Information blocks may be generated
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`within this form by selecting the Add button.
`Add
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`Correspondence Information:
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`Enter either Customer Number or complete the Correspondence Information section below.
`For further information see 37 CFR 1.33(a).
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`An Addressis being provided for the correspondenceInformationof this application.
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`Customer Number 96387
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`docket@bozpat.comEmail Address Add Email
`
`Application Information:
`Title of the Invention
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
`
`
`
`
`Attorney Docket Number|REGN-008CIPCON10 Small Entity Status Claimed C]
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`Application Type
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`Nonprovisional
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`Subject Matter
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`Utility
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` Total NumberofDrawing Sheets(ifany) | 1 Suggested Figurefor Publication (ifany) | 1
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`WEB ADS1.0
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`Celltrion Exhibit 1014
`Page 18
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`Celltrion Exhibit 1014
`Page 18
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`

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`PTO/AIA/14 (08-15)
`Approved for use through 04/30/2017. OMB 0651-0032
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no personsare required to respond to a collection of information unlessit containsa valid OMB control number.
`
`Attorney Docket Number
`REGN-OO8CIPCON10
`
`Application Data Sheet 37 CFR 1.76
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`
`Title of Invention
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
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` Application Number
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`Filing By Reference:
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`Only complete this section whenfiling an application by reference under 35 U.S.C. 111(c) and 37 CFR 1.57(a). Do not completethis sectionif
`application papers including a specification and any drawings are being filed. Any domestic benefit or foreign priority information must be
`provided in the appropriate section(s) below (i.e., "Domestic Benefit/National Stage Information” and “Foreign Priority Information’).
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`For the purposesofa filing date under 37 CFR 1.53({b), the description and any drawings of the present application are replaced bythis
`reference to the previouslyfiled application, subject to conditions and requirements of 37 CFR 1.57(a).
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`35 U.S.C.
`Request Not to Publish. | hereby request that the attached application not be published under
`122(b) and certify that the invention disclosed in the attached application has not andwill not be the subject of an
`application filed in another country, or under a multilateral international agreement, that requires publication at eighteen
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`Representative information should be provided for all practitioners having a power of attorney in the application. Providing
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`will be used for the Representative Information during processing.
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`Please Select One:
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`Customer Number
`96387
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`Prefix
`Given Name
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`Family Name
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`Registration Number
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`Given Name
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`WEB ADS 1.0
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`Celltrion Exhibit 1014
`Page 19
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`Celltrion Exhibit 1014
`Page 19
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`

`

`PTO/AIA/14 (08-15)
`Approved for use through 04/30/2017. OMB 0651-0032
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no personsare required to respond to a collection of information unlessit containsa valid OMB control number.
`
`
`Application Data Sheet 37 CFR 1.76
`
`Attorney Docket Number
`
`REGN-OO8CIPCON10
`
`Application Number
`
`Title of Invention
`
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
`
`
`
`
`
`Domestic Benefit/National Stage Information:
`
`This section allows for the applicant to either claim benefit under 35 U.S.C. 119(e), 120, 121, 365(c), or 386(c) or indicate National
`Stage entry from a PCT application. Providing benefit claim information in the Application Data Sheet constitutes the specific
`reference required by 35 U.S.C. 119(e) or 120, and 37 CFR 1.78.
`Whenreferring to the current application, please leave the “Application Number’field blank.
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`
`Prior Application Status|Pending
`Filing or 371(c) Date
`Application Number
`Continuity Type
`Prior Application Number
`(YYYY-MM-DD}
`
`Continuation of
`17350958
`2021-06-17
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`
`Prior Application Status|Pending
`Filing or 371(c) Date
`Application Number
`Continuity Type
`Prior Application Number
`(YYYY-MM-DD}
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`17350958
`Continuation of
`17112404
`2020-12-04
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`Application Number
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`Prior Application Status|Pending Remove
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`Filing or 371(c) Date
`(YYYY-MM-DD)
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`Continuity Type
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`Prior Application Number
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`17112404
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`Continuation of
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`17072417
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`2020-10-16
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`Prior Application Status|Patented Remove
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`
`
`Application
`.
`Prior Application
`Filing Date
`Issue Date
`Number
`Continuity Type
`Number
`CYYYY-MM-DD)
`Patent Number
`(YYYY-MM-DD)
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`17072417
`Continuation of
`16055847
`2018-08-06
`10857205
`2020-12-08
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`Prior Application Status|Patented
`Application
`-
`Prior Application
`Filing Date
`Issue Date
`Number
`Continuity Type
`Number
`(YYYY-MM-DD)
`Patent Number
`(YYYY-MM-DD)
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`17072417
`Continuation of
`16397267
`2019-04-29
`10888601
`2021-01-12
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`Remove
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`Prior Applicati ion Status|Patented
`Issue Date
`Filing Date
`Prior Application
`wo
`Application
`Number
`Continuity Type
`Number
`(YYYY-MM-DD}
`Patent Number
`(YYYY-MM-DD)
`16397267
`Continuation of
`16159282
`2018-10-12
`10828345
`2020-11-10
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`Prior Application Status|Patented Remove
`Application
`_
`Prior Application
`Filing Date
`Issue Date
`Number
`Continuity Type
`Number
`(YYYY-MM-DD}
`(YYYY-MM-DD)
`16159282
`Continuation of
`15471506
`2017-03-28
`2018-11-20
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`Patent Number
`10130681
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`WEB ADS1.0
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`Celltrion Exhibit 1014
`Page 20
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`Celltrion Exhibit 1014
`Page 20
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`

`

` REGN-O08CIPCON10
` Attorney Docket Number
` USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
` Remove
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`
`PTO/AIA/14 (08-15)
`Approved for use through 04/30/2017. OMB 0651-0032
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respondto a collection of information unlessit containsa valid OMB control number.
`
`Application Data Sheet 37 CFR 1.76
`
`Application Number
`
`Title of Invention
`
`
` This section allows for the applicant to claim priority to a foreign application. Providing this information in the application data sheet
`
`Patented
`
`Prior Application Status
`Application
`.
`Prior Application
`Filing Date
`Issue Date
`Number
`Continuity Type
`Number
`(YYYY-MM-DD}
`Patent Number
`(YYYY-MM-DD)
`
`15471506
`Continuation of
`14972560
`2015-12-17
`9669069
`2017-06-06
`
`
`Prior Application Status|Patented
`Application
`os
`Prior Application
`Filing Date
`Issue Date
`Number
`Continuity Type
`Number
`(YYYY-MM-DD}
`Patent Number
`(YYYY-MM-DD)
`14972560
`Continuation of
`13940370
`2013-07-12
`9254338
`2016-02-09
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`
`
` Remove
`Filing or 3/1(c) Date
`Continuity Type
`Prior Application Number
`Application Number
`(YYYY-MM-DD)
`13940370
`2012-01-11
`
`Continuationin part of
`
` Remove
`Filing or 371(c) Date
`Continuity Type
`Prior Application Number
`Application Number
`(YYYY-MM-DD)
`2011-01-13
`PCT/US2012/020855
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`Prior Application Status
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`Claims benefit of provisional
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`PCT/US2012/020855
` 61432245
`61434836 2011-01-21
`
`Prior Application Status
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`Remove
`
`Filing or 371(c) Date
`Continuity Type
`Prior Application Number
`Application Number
`(YYYY-MM-DD)
`PCT/US2012/020855
`
`Claims benefit of provisional
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`
`Prior Application Status|Expired
`Filing or 371(c) Date
`Application Number
`Continuity Type
`Prior Application Number
`(YYYY-MM-DD}
`
`Additional Domestic Benefit/National Stage Data may be generated within this form by
`selecting the Add button.
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`Foreign Priority Information:
`
`constitutes the claim forpriority as required by 35 U.S.C. 119(b) and 37 CFR 1.55. When priority is claimed to a foreign application thatis eligible
`for retrieval under the priority document exchange program (PDX) the information Will be used by the Office to automatically attempt retrieval
`pursuant to 37 CFR 1.55(i)(1) and (2). Under the PDX program, applicant bearsthe ultimate responsibility for ensuring that a copy of the foreign
`application is received by the Office from the participating foreign intellectual property office, or a certified copy of the foreign priority
`application is filed, within the time period specified in 37 CFR 1.55(g)(1).
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`WEB ADS1.0
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`Celltrion Exhibit 1014
`Page 21
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`
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`Claims benefit of provisional 61561957PCT/US2012/020855 2011-11-21
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`Celltrion Exhibit 1014
`Page 21
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`

`

`PTO/AIA/14 (08-15)
`Approved for use through 04/30/2017. OMB 0651-0032
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respondto a collection of information unlessit containsa valid OMB control number.
`
`oe
`Application Data Sheet 37 CFR 1.76
`
`Attorney Docket Number
`
`REGN-O08CIPCON10
`
`Application Number
`
` .
`
`
`
`
`
`
`
`
`
`
`Title of Invention
`
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
`
`Application Number
`
`Filing Date (YYYY-MM-DD)
`
`Access Codelif applicable)
`
`Additional Foreign Priority Data may be generated within this form by selecting the Add
`button.
`
`Statement under 37 CFR 1.55 or 1.78 for AIA (First Inventor to File) Transition
`Applications
` This application (1) claims priority to or the benefit of an application filed before March 16, 2013 and (2) also
`contains, or contained at any time, a claim to a claimed invention that hasan effectivefiling date on or after March
`[J 16, 2013.
`NOTE:By providing this statement under 37 CFR 1.55 or1.78, this application, withafiling date on or after March
`16, 2013,will be examined underthe first inventorto file provisions of the AIA.
`
`
`
`
`
`WEB ADS 1.0
`
`Celltrion Exhibit 1014
`Page 22
`
`Celltrion Exhibit 1014
`Page 22
`
`

`

`PTO/AIA/14 (08-15)
`Approved for use through 04/30/2017. OMB 0651-0032
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no personsare required to respond to a collection of information unlessit containsa valid OMB control number.
`
`oe
`.
`Application Data Sheet 37 CFR 1.76
`
`Attorney Docket Number
`
`REGN-O08CIPCON10
`
`USE OF A VEGF ANTAGONIST TO TREAT ANGIOGENIC EYE DISORDERS
`
`Application Number Title of Invention
`
`
`
`
`
`
`Authorization or Opt-Out of Authorization to Permit Access:
`
`Whenthis Application Data Sheet is properly signed andfiled with the application, applicant has provided written authority to
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